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Dissertations / Theses on the topic 'Terapia specifica'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

RELLA, VALERIA. "AMILOIDOSI CARDIACA ANALISI DI PREVALENZA IN DUE STUDI MULTICENTRICI ITALIANI." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2022. http://hdl.handle.net/10281/366496.

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Tra i pazienti con diagnosi iniziale di cardiomiopatia ipertrofica afferiti a Centri di Riferimento per le Cardiomiopatie, l’AC è la malattia non riconosciuta più comune con una prevalenza complessiva del 9%, e che aumenta con l'età (dall'1% nella fascia di età tra i 40-49 anni al 26% sopra gli 80 anni). Nella popolazione generale ≥55 anni più del 7% ha almeno un reperto ecocardiografico suggestivo di AC e l’ispessimento del setto interatriale è quello più frequente. I pazienti con elevato sospetto di AC (≥3 reperti) rappresentano l’1% della popolazione generale e il 4,9% di quelli con cuore n

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2

ANSELMI, ALESSIA. "Dinamica virale e risposta immune HIV-1-specifica in neonati sottoposti a terapia antiretrovirale ed immunoricostituzione in bambini infettati da HIV-1 con differente risposta virologica alla terapia." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2008. http://hdl.handle.net/2108/555.

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Introduzione. L'infezione perinatale da HIV-1 è acquisita quando il sistema immunitario del bambino è in fase di sviluppo ed è caratterizzata da un'elevata e non controllata replicazione virale. La terapia antiretrovirale altamente efficace (HAART), che genericamente prevede l'utilizzo di inibitori della proteasi e della trascrittasi inversa, riduce efficientemente la carica virale di HIV-1 sotto livelli non rilevabili e aumenta il numero di cellule T CD4+ circolanti nei bambini come negli adulti. Al fine di incrementare le scarse informazioni sul trattamento precoce con HAART e sull'immunoric

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CAROLLO, VALERIA. "Terapie antitumorali per bersagli molecolari specifici: heat shock protein 90 Hsp90." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2013. http://hdl.handle.net/2108/203197.

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4

Riili, Anna <1973&gt. "Studio immunologico per l'individuazione di pazienti trapiantati per cirrosi HBV relata che potrebbero sospedere la terapia con immunoglobine specifiche (HBIG)." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2009. http://amsdottorato.unibo.it/2240/1/Anna_Riili_tesi.pdf.

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Hepatitis B virus (HBV) recurrence after orthotopic liver transplantation (OLT) is associated with poor graft and patient survival. Treatment with HBV-specific immunoglobulins (HBIG) in combination with nucleos(t)ide analogs is effective in preventing HBV reinfection of the graft and improving OLT outcome. However, the combined immunoprophylaxis has several limitations, mainly the high cost and the lack of standard schedules about duration. So far, the identification of markers able to predict the reinfection risk is needed. Although the HBV-specific immune response is believed to play an esse

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Riili, Anna <1973&gt. "Studio immunologico per l'individuazione di pazienti trapiantati per cirrosi HBV relata che potrebbero sospedere la terapia con immunoglobine specifiche (HBIG)." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2009. http://amsdottorato.unibo.it/2240/.

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Hepatitis B virus (HBV) recurrence after orthotopic liver transplantation (OLT) is associated with poor graft and patient survival. Treatment with HBV-specific immunoglobulins (HBIG) in combination with nucleos(t)ide analogs is effective in preventing HBV reinfection of the graft and improving OLT outcome. However, the combined immunoprophylaxis has several limitations, mainly the high cost and the lack of standard schedules about duration. So far, the identification of markers able to predict the reinfection risk is needed. Although the HBV-specific immune response is believed to play an esse

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6

SFERRA, Daniela. "Studio dell’espressione di specifici recettori di superficie nel contesto dell’urotelio e valutazione del loro possibile impiego nella terapia delle infezioni cronico-ricorrenti delle vie urinarie." Doctoral thesis, Università degli studi del Molise, 2012. http://hdl.handle.net/11695/66237.

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Le infezioni del tratto urinario (UTIs) sono fra le più frequenti infezioni umane. Escherichia coli è l’agente eziologico più comunemente isolato, responsabile dell’85% delle batteriurie asintomatiche e dei casi di cistiti acute non complicate. L’adesione di E.coli uropatogeni (UPEC) alle cellule uroepiteliali è determinato da specifiche interazioni tra le adesine del patogeno e i recettori della cellula ospite. Tali infezioni rappresentano anche una delle più frequenti complicanze di molte patologie neurodegenerative. Sebbene la maggiore suscettibilità dei pazienti neuropatici alle UTIs sia

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7

Freitas, Raysa Vanessa de Medeiros. "Validade e confiabilidade das vers?es original e curta da escala Activities-Specific Balance Confidence (ABC-16 e ABC-6) para idosos brasileiros residentes na comunidade." PROGRAMA DE P?S-GRADUA??O EM FISIOTERAPIA, 2018. https://repositorio.ufrn.br/jspui/handle/123456789/24997.

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Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2018-04-02T15:20:07Z No. of bitstreams: 1 RaysaVanessaDeMedeirosFreitas_DISSERT.pdf: 1441664 bytes, checksum: 48e9822af12723aec191fe48069617d7 (MD5)<br>Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2018-04-06T11:41:38Z (GMT) No. of bitstreams: 1 RaysaVanessaDeMedeirosFreitas_DISSERT.pdf: 1441664 bytes, checksum: 48e9822af12723aec191fe48069617d7 (MD5)<br>Made available in DSpace on 2018-04-06T11:41:38Z (GMT). No. of bitstreams: 1 RaysaVanessaDeMedeirosFreitas_DISSERT.pdf: 1441664 bytes,

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Grau, Vorster Marta. "Development and characterisation of advanced cell therapies based on multipotent mesenchymal stromal cells and virus-specific Tlymphocytes." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/669379.

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El desenvolupament de noves teràpies s’està duent a terme arreu del món per poder fer front a les necessitats clíniques que actualment no disposen de tractament. En particular, els avenços en productes medicinals de teràpia avançada (ATMP) són una gran promesa per al tractament de malalties sense altres opcions terapèutiques. Tanmateix, els investigadors i les autoritats reguladores que implementen aquestes teràpies lluiten per estandarditzar tant els protocols com els productes finals. Entre els reptes s’inclouen l’elevada intervariabilitat de donants i mecanismes d’acció complexos. A més, és

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9

BIONDI, MARTA. "Enhancing AML CAR CIK therapeutic potency increasing the localization of engineered cells in the malignant niche and its selectivity by LSCs specific targeting." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2022. http://hdl.handle.net/10281/365153.

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La terapia CAR-T rappresenta un approccio promettente, ma ha riportato una ridotta efficacia nella leucemia mieloide acuta (AML), a causa dell’eterogeneità del tumore, dell’assenza di antigeni target AML-specifici e del ruolo del microambiente leucemico nella protezione dei blasti e delle cellule staminali leucemiche (LSC). La nicchia midollare, nella quale risiedono le LSC, è coinvolta in attività che promuovono la progressione leucemica e sopprimono l’ematopoiesi sana. Quindi ipotizziamo che bersagliare le LSC nascoste nella nicchia potesse migliorare l’efficacia delle CAR-T. Per testare la

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10

Gahyva, Dáphine Luciana Costa. "Eficácia da intervenção fonoaudiológica em crianças com distúrbio específico da linguagem." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/25/25143/tde-14062007-142629/.

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O objetivo deste estudo foi comparar o desempenho psicolingüístico de crianças com Distúrbio Específico de Linguagem (DEL) com o de crianças que apresentam desenvolvimento típico de linguagem (DTL), apontando os marcadores psicolingüísticos mais significativos do distúrbio e também comparar a eficácia de dois métodos de intervenção - Modelo de Intervenção no Meio e Modelo Neuropsicolingüístico - no desempenho psicolingüístico das crianças com DEL. Participaram desta investigação 12 pré-escolares de ambos os gêneros, com idade entre 4:0 - 6:11 anos, sendo metade deles pertencentes ao grupo expe

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11

Soto-Iglesias, David. "Development and evaluation of mapping strategies for the integration and joint analysis of multi-modal data of the heart." Doctoral thesis, Universitat Pompeu Fabra, 2016. http://hdl.handle.net/10803/395191.

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The development of novel technologies is allowing a complete description of the heart structure and function, including geometrical, myocardial tissue viability and electrical activation information. The joint analysis of this information helps to improve clinical interventions such as radio-frequency ablation of cardiac arrhythmias. However, the acquired data and related indices need to be integrated onto a common reference space for its analysis. This integration is not straightforward due to the different characteristics of acquisition systems. The aim of this thesis was to develop and eva

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12

Dvořák, Jiří. "Biofeedback a jeho použití." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2009. http://www.nusl.cz/ntk/nusl-217977.

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The aim of this work is describe common methods of biological feedback therapy that is used to treat some psychosomatic diseases. Subsequently, the description is focused on minimal brain dysfunction treatment by the help of EEG biofeedback. Properties and technical requirements for this therapy are concretized. The last part of this thesis is dedicated to the design and realization of practical software tool for EEG biofeedback therapy which is made in LabView 7.1. The M535 acquisition unit and NI USB-6221 measuring device are used for hardware solution.

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13

Kazdová, Milada. "Specifika terapie gestačního diabetes mellitus." Master's thesis, 2006. http://www.nusl.cz/ntk/nusl-272226.

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14

Parýzková, Barbora. "Radioaktivně značené receptorově-specifické peptidy pro diagnostiku a terapii nádorů." Master's thesis, 2018. http://www.nusl.cz/ntk/nusl-380771.

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Charles University Fakulty of Pharmacy in Hradec Králové Department of Biophysics and Physical Chemistry Candidate: Bc. Barbora Parýzková Supervisor: Mgr. Pavel Bárta, Ph.D. Title of diploma thesis: Radiolabelled receptor-specific peptides for cancer diagnosis and therapy. The presented diploma thesis is based on literature review and it deals with receptor- specific radioactive labeled peptides and their usage in the cancer diagnostic and treatment. It focuses on general knowledge about radiopharmaceuticals, further on the descriptions of either diagnostic or therapeutic radionuclides as well

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15

Saraiva, Claudia Marisa Monteiro. "Development of lipoplex formulations for specific genetic material delivery to pancreatic cancer cells." Master's thesis, 2012. http://hdl.handle.net/10316/25008.

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Dissertação de mestrado em Bioquimica apresentada ao Departamento Ciências da Vida da Faculdade de Ciências e Tecnologia da Universidade de Coimbra<br>O adenocarcinoma do pâncreas é a quarta causa de morte do mundo ocidental sendo, dos tumores sólidos, o mais letal. Pacientes diagnosticados com cancro do pâncreas apresentam um prognóstico extremamente pobre com uma sobrevivência média inferior a 6 meses e uma taxa de sobrevivência de 3% a 5%. A cirurgia continua a ser a única forma de tratamento. Infelizmente, apenas 10 a 20% dos pacientes apresentam tumores operáveis aquando do diagnóstico. P

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16

Perdigão, Pedro Ricardo Lucas 1987. "Specific elimination of HIV-1 infected cells using Tat/Rev-dependent circuit." Master's thesis, 2011. http://hdl.handle.net/10451/6467.

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Tese de mestrado. Biologia (Biologia Molecular e Genética). Universidade de Lisboa, Faculdade de Ciências, 2011<br>Despite the success of antiretroviral cocktails, a cure for HIV-1 remains elusive. This is mainly due to the existence of persistent cellular reservoirs infected with non-transcriptional, latent HIV-1. An effective treatment against HIV-1 would target both active and latent HIV-1-infected cells, and eliminate them without harming non-infected cells. In order to achieve this, we have developed a therapeutic plasmid with a Tat/Rev-dependent toxin expression. This vector contains a H

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17

Hadlová, Petra. "Cytometrický test antigen-specifické T buněčné odpovědi pro monitoring terapií BCG vakcínou." Master's thesis, 2019. http://www.nusl.cz/ntk/nusl-392927.

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Bladder carcinoma (BCa) is among the most common carcinomas in the Western world. Despite the availability of effective therapies, there is currently an urgent need to develop a stratification method, which would enable the accurate identification of patients responsive to therapy. In the theoretical part of my diploma project I describe the heterogeneity of BCa and the currently applied immunotherapeutic approaches. I specifically focused on the Bacillus Calmette-Guérin (BCG) vaccine instillation. For decades another use of BCG has been a prophylactic vaccination against tuberculosis (TB) inf

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18

Perglerová, Vendula. "Specifika práce s dospívajícími problémovými uživateli drog." Master's thesis, 2011. http://www.nusl.cz/ntk/nusl-313173.

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Thesis abstract Author's name: Vendula Perglerová School: Charles University in Prague, Philosophical Faculty, Department of Education Program: Master full-time study of education Title: Specifics of work with adolescent drug abusers Consultant: PhDr. M. Vítečková, Ph.D. Number of pages: 97 Key words: addiction, drug, adolescent drug users, therapy, case study The aim of this thesis is to understand the mechanisms of addiction in adolescent drug users, to describe their specifics and to provide on this basis a guide to choosing effective means of help in treatment of adolescent drug abusers. I

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19

Širl, Radim. "Narativy a náboženství: specifika a funkce příběhů v náboženských kontextech." Master's thesis, 2016. http://www.nusl.cz/ntk/nusl-343089.

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The aim of this thesis is to analyse certain aspects connecting religion and narration (which is understood here as a common human faculty to think and express oneself in the form of narratives). The first part of the thesis is concerned with methodology; first of all, the issues of defining narrative are introduced and a more elaborate definition is presented. A complete methodology is then formulated with a help of several authors (mainly James W. Pennebaker and Mary Douglas) in order to distinguish particularities and functions of creating narratives in religious contexts. Two main points a

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20

Holakovská, Eva. "Terapeutická komunita v systému léčby drogově závislých a její specifické terapeutické programy." Master's thesis, 2011. http://www.nusl.cz/ntk/nusl-300521.

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This thesis is focused on therapeutic communities in the treatment system of drug addicted clients and on their methods, programs and mission of employed therapists to achieve better restoration of the drug addicted clients. The aim of this work is to widely describe the treatment process in therapeutic communities and zoom in an enviroment and whole treatment system which creates safety place for each member of the community. The thesis is divided into a theoretical and practical part. Theoretical part describes today's czech experience in therapeutic communities, whereas the importance is la

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21

ŠTĚPÁNOVÁ, Hana. "Specifické potřeby pacientů při léčbě ran negativním podtlakem." Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-320735.

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The diploma thesis entitled Specific needs of patients during negative pressure wound therapy, consists of two main parts, a theoretical and a practical part. The theoretical part includes findings from research and publications dealing with the issues of wound healing through local application of vacuum therapy, treatment with other methods of wet healing, the impact of long-term non-healing wounds on human needs and the role of the nurse in this scenario. The practical part of the diploma thesis refers to the quantitative research carried out by 46 respondents who were treated with a negativ

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22

Martins, Sara Alexandra Nascimento Costa e. Pires. "Impacto dos Polimorfismos de Nucleótido Único em Genes Associados a Doenças de Poliglutaminas para o Desenvolvimento de Terapias Génicas." Master's thesis, 2021. http://hdl.handle.net/10316/98973.

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Dissertação de Mestrado em Biotecnologia Farmacêutica apresentada à Faculdade de Farmácia<br>Polyglutamine diseases are a group of nine neurodegenerative diseases caused by the abnormal expansion of the CAG trinucleotide in the coding region of the gene, which originates a mutant protein with a typical segment of polyglutamines. The mutant protein becomes toxic and it leads to progressive neuronal dysfunction and death that gradually limits patients’ lives. Polyglutamine diseases include Huntington's Disease, Dentatorubral Pallidoluysian Atrophy, Spinal and Bulbar Muscular Atrophy, and Spinoce

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23

EISERTOVÁ, Jaroslava. "Canisterapie jako podpůrná terapeutická metoda u dětí s hyperkinetickým syndromem a dětskou mozkovou obrnou." Doctoral thesis, 2009. http://www.nusl.cz/ntk/nusl-52476.

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24

Silva, Joana Balça Pinheiro da Costa e. "Molecular Mechanisms of Glioblastoma Resistance: glioma stem-like and non-stem-like cells specific targets." Doctoral thesis, 2018. http://hdl.handle.net/10316/79716.

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Tese de doutoramento do Programa Interuniversitário de Doutoramento em Envelhecimento e Doenças Crónicas, apresentada à Faculdade de Medicina da Universidade de Coimbra<br>Glioblastoma (GBM) is the most malignant primary tumor of the central nervous system. Despite all efforts, the median survival time for GBM patients remains approximately between 12 to 15 months under therapy. GBM is a diffuse astrocytoma, highly proliferative, angiogenic, and locally invasive, that develops resistance to the alkylating agents used in chemotherapy, such as temozolomide (TMZ), which is considered part of the

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