Academic literature on the topic 'Terbinafin'

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Journal articles on the topic "Terbinafin"

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Mayser, P. "Terbinafin." Der Hautarzt 67, no. 9 (July 25, 2016): 724–31. http://dx.doi.org/10.1007/s00105-016-3844-9.

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Dürrbeck, A., and P. Nenoff. "Terbinafin." Der Hautarzt 67, no. 9 (July 29, 2016): 718–23. http://dx.doi.org/10.1007/s00105-016-3853-8.

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Schmid-Wendtner, M. H., and H. Korting. "Terbinafin-Topika." Der Hautarzt 59, no. 12 (November 7, 2008): 986–91. http://dx.doi.org/10.1007/s00105-008-1552-9.

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Lukács, Péter, Zsuzsánna Károlyi, Tibor Barna, and István Mórocz. "Terbinafine induced SCLE apropos of two cases." Bőrgyógyászati és Venerológiai Szemle 91, no. 5 (November 20, 2015): 174–77. http://dx.doi.org/10.7188/bvsz.2015.91.5.2.

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Korting, H. C. "Synergistische Effekte der Antimykotika Terbinafin und Itraconazol." Der Hautarzt 50, no. 1 (January 22, 1999): 56–57. http://dx.doi.org/10.1007/s001050050866.

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Wilmer, A., and U. Wollina. "Systemische Terbinafin-Therapie von Dermatophytosen im Kindesalter." Mycoses 41 (October 1998): 54–57. http://dx.doi.org/10.1111/j.1439-0507.1998.tb00603.x.

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Breuer, K., B. Völker, R. Gutzmer, A. Kapp, and T. Werfel. "Pigmentierung des Gesichtes unter Therapie mit Terbinafin." Der Hautarzt 56, no. 11 (November 2005): 1056–59. http://dx.doi.org/10.1007/s00105-004-0888-z.

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Sultana, Razia, and Md Wahiduzzaman. "Emerging threat in antifungal resistance on superficial dermatophyte infection." Bangladesh Medical Journal Khulna 51, no. 1-2 (March 4, 2019): 21–24. http://dx.doi.org/10.3329/bmjk.v51i1-2.40469.

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Background: Dermatophytosis are most common fungul infection globally and according to WHO the prevalence is about 20-25% and does not spare people of any race or age. Over the past few years antifungal resistance has been emerged due to irrational use of antifungal drugs in cutaneous mycosis. Objective: The aim of the study is to evaluate the efficacy of different antifungul drugs (Terbinafin. Fluconazole, Itraconazole, Griseofulvin) on superficial mycosis depending on various factors. Methods: This prospective study was conducted among the Superficial fungul infected patients from April' 2017 to October 2017 in Khulna Medical College Hospital (KMCH) and dermatologist's private chamber in Khulna city. All the enrolled patients were put on oral Terbinafin, Fluconazole, Itraconazole and Griseofulvin. Each patient was given single antifungal drug orally. These cases were thus followed up after two months of treatment to look for persistent infection, cure or any relapse clinically. Result: Among 194 patient 89 were given Tab. Terbinafin (250mg) where resistance cases were 20.22%. More cases (33.96%) were resistant to Cap. Fluconazol (50mg). High percentage of cases were resistant to Cap. Itraconazole (76.47%). Griseofulvin resistant cases were observed in 25.71%. Drug response is very poor (69%) in patient who had been suffering from diabetes mellitus. Conclusion: Appropriate antifungal drugs should be chosen with strict indication, dose, duration, selection of perfect local preparation and taking laboratory facilities where necessary. Bang Med J (Khulna) 2018; 51 : 21-24
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Borelli, Siegfried, and Stephan Lautenschlager. "Dermatophyten-Infektion der Haut und der Nägel." Therapeutische Umschau 73, no. 8 (October 2016): 457–61. http://dx.doi.org/10.1024/0040-5930/a000818.

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Zusammenfassung. Dermatophyten verursachen die überwiegende Mehrzahl von Mykosen an Haut und Nägeln, die dann als Tinea bezeichnet werden. Bei typischer Klinik mit randbetontem, schuppenden Erythem, zentralem Abblassen und zentrifugaler Ausbreitung sollte ein Erregernachweis mittels Direktpräparat und Kultur erfolgen. Die unkritische Behandlung unklarer Befunde mit topischen Steroiden sollte ebenso wie der Einsatz von Kombinationspräparaten mit Antimykotikum und Kortikosteroid vermieden werden um nicht durch Maskierung der Klinik eine Tinea incognita zu provozieren. Therapeutisch ist Terbinafin sowohl topisch als auch systemisch das Präparat mit dem besten Kosten/Nutzen-Verhältnis. Auch bei der Onychomykose weist Terbinafin aufgrund der mykoziden Wirkung höhere Abheilungsraten auf. Chronische Lebererkrankungen sind eine Kontraindikation. Interaktionen mit Antidepressiva sind zu beachten. Betablocker sollten nicht zeitgleich eingenommen werden. Gleichzeitige Einnahme von Lipidsenkern stellt im Gegensatz zu den Azolen jedoch kein Problem dar. Bei therapieresistenten Onychomykosen – am häufigsten striäre Varianten – muss unter Umständen eine Nagelteilavulsion oder Keratolyse mit 40 % Urea erfolgen.
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Mashkilleyson, A. L., and M. A. Gomberg. "The effect of terbinafin in some extensive dermatomycoses." Journal of Dermatological Science 6, no. 1 (August 1993): 116. http://dx.doi.org/10.1016/0923-1811(93)91394-a.

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Dissertations / Theses on the topic "Terbinafin"

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Balda, Ana Claudia. "Avaliação das concentrações de terbinafina no pelame de gatos da raça Persa com dermatofitose e daqueles portadores de Microsporum canis tratados em esquema de pulsoterapia ou terapia contínua." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/10/10136/tde-21072011-132952/.

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A dermatofitose é micose superficial desencadeada, principalmente, pelo Microsporum canis e de ocorrência comum nos felinos da raça Persa. Objetivou-se no presente estudo avaliar e comparar a melhora clínica e negativação micológica nos animais tratados com a terbinafina em pulsoterapia em relação a terapia contínua; evidenciar o acúmulo de terbinafina no pelame e o tempo em que o fármaco permanece em doses terapêuticas após a suspensão de sua administração; correlacionar a melhora clínica com a quantificação do fármaco no pelame; comparar a ocorrência de efeitos colaterais em pulsoterapia em relação a terapia contínua.. Foram incluídos nesse estudo, 27 gatos da raça Persa, 17 portadores assintomáticos e 10 sintomáticos do M. canis, o Grupo I foi composto por 13 fêmeas tratadas em pulsoterapia. Durante os primeiros sete dias a terbinafina foi administrada na dose de 20 mg/kg a cada 24 horas por via oral, seguidos por um período de suspensão da medicação pelos 21 dias subseqüentes, posteriormente foi realizado um segundo ciclo de sete dias, na dose de 40 mg/kg a cada 24 horas, novamente seguidos por um período de suspensão do fármaco nos 21 dias posteriores. O Grupo 11 foi constituído por 14 machos, que receberam terapia contínua, durante 56 dias. Nos primeiros 28 dias foi administrada a dose de 20 mg/kg a cada 24 horas por via oral e nos 28 dias subseqüentes a dose foi aumentada para 40 mg/kg diários. Os animais foram submetidos à duas colheitas de pelame pela Técnica do carpete com intervalo de 15 dias, anteriormente e posteriormente à terapia. Também eram realizadas colheitas de pelame nos dias zero, sete, 28, 35 e 56 dias para realização da quantificação das concentrações de terbinafina no pelame dos animais tratados, pela cromatografia líquida de alta performance (HPLC). Quinzenalmente, colhia-se sangue para realização de função hepática. Houve cura clínica e micológica em 100% dos animais tratados, as concentrações de terbinafina no pelame dos gatos se mantiveram acima daquelas consideradas terapêuticas por 21 dias após a pulsoterapia de sete dias, tanto na dose de 20, quanto na dose de 40 mg/kg diários, mas ocorreu maior acúmulo do fármaco na dose mais alta em terapia contínua, todavia esses animais apresentaram episódios eméticos na primeira semana de terapia, além de aumento da atividade sérica das transferases e da fosfatase alcalina. Já no grupo da pulsoterapia, não houve aumento da atividade sérica das enzimas hepáticas. A terbinafina foi eficaz e segura no tratamento de portadores sintomáticos e assintomáticos de M. canis.
Dermatophytosis is a superficial mycosis caused mainly by Microsporum canis and is very common in Persian cats. The goals of this study were: to evaluate the clinical and mycological cure in the animais treated with terbinafine in pulse therapy compared with continuous therapy; the accumulation of terbinafine in cats hair and the time that it is maintained in therapeutical concentrations after its suspension; correlates the clinical cure with the quantity of the drug in the hair and compare the side effects in pulse therapy in relation to continuous therapy. In this study were included 27 Persian cats, 17 healthy carriers of M. canis and 10 cats with dermatophytosis. The group I was composed of 13 females treated with pulse therapy, during the first seven days in the dosis of 20 mg/kg, daily, followed by a period of suspension of the medication for 21 days, subsequently, it was realized a new cycle of therapy, more seven days of terbinafine in the dosis of 40 mg/kg daily, repeating a period of suspension for another 21 days . The group 11 was composed of 14 males, that received continuous therapy, during 56 days, in the first 28 days they received the oral dosis of 20 mg/kg daily and 40 mg/kg daily for the next 28 days. The animais were submitted to two mycological cultures collected by the carpet square method with 15 days of interval, before and after the therapy. It was realized also manual avulsion of the cats hair for the quantification of terbinafine by high performance liquid chromatography (HPLC) in the days zero, seven, 28, 35 and 56. Every 15 days, blood samples were taken for hepatic function evaluation. There were clinical and mycological cure in 100% of treated animais; the concentrations of terbinafine in cats hair were maintained above therapeutical concentrations in pulse therapy in the dosis of 20, and also in 40 daily oral administration, but there was a higher accumulation of the drug when it was used in the higher dosis in continuous therapy. Although were seen emesis in the first week of therapy, and also higher serical activities of hepatic enzymes. There were no alterations in the values of AL T and FA in the pulse therapy group. Terbinafine had good efficacy and was secure for the treatment of healthy carriers of M. canis and also in animais with dermatophytosis.
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Breia, Maria Inês Mendonça dos Santos. "Utilização de um composto à base de florfenicol, betametasona e terbinafina no tratamento de otite externa diagnosticada por citologia." Master's thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2017. http://hdl.handle.net/10400.5/14346.

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Dissertação de Mestrado Integrado em Medicina Veterinária
A otite externa é uma das doenças mais frequentes nos cães, afetando 10 a 20% dos animais. Os microrganismos mais frequentemente isolados são Malassezia pachydermatis e Staphylococcus pseudintermedius, agentes comensais que em presença de condições propícias podem iniciar sobrecrescimento. A deteção de Malassezia spp. e de Staphylococcus spp. por citologia é prática comum na clínica para diagnóstico e avaliação de resposta ao tratamento de otites externas. Este estudo teve como objetivo determinar a eficácia de um composto à base de florfenicol, betametasona e terbinafina no tratamento de otite externa diagnosticada por citologia em 48 aplicações em cães do Hospital Veterinário Sul do Tejo. A natureza da infeção correspondia a 71% infeções por Malassezia spp., 19% infeções mistas e 10% infeções bacterianas. Este composto medicamentoso revelou ser eficaz em 81% das aplicações, sendo que as restantes ocorreram em animais com dermatite atópica e cujo episódio de otite era recorrente. Tanto a dermatite atópica como o facto de ser recorrente demonstraram ter uma relação significativa com o insucesso terapêutico (p < 0,001 e p = 0,043, respetivamente). Esta combinação farmacológica demonstrou potencial interesse, uma vez que se revelou eficaz na maioria dos casos e, aliado à grande vantagem da sua posologia, deverá ser considerada na escolha terapêutica da otite externa. Palavras-
ABSTRACT - Otitis externa is one of the most common diseases in dogs, affecting 10 to 20% of animals. The most commonly isolated microorganisms are Malassezia pachydermatis and Staphylococcus pseudintermedius, which are commensal, although the presence of certain conditions can lead to their overgrowth and pathogenic change. Cytological identification of Malassezia spp. and Staphylococcus spp. is a common clinical approach for the diagnosis and assessment in the treatment of external otitis. The present study aims to determine the efficacy of a medicine containing florfenicol, betamethasone and terbinafine in the treatment of external otitis diagnosed by cytology in 48 applications in dogs examined in Hospital Veterinário Sul do Tejo. The nature of the infections was 71% Malassezia spp., 19% mixed infection and 10% bacterial infection. This topical treatment was effective in 81% of all applications. Failure occurred in dogs with atopy and recurrent otitis. Both atopy and recurrence were demonstrated to have a significant relation with lack of success (p < 0,001 e p = 0,43, respectively). This pharmacological combination has demonstrated potential interest for its efficiency in most cases allied to the great advantage of dosage. Therefore, it should be considered for treatment of otitis externa.
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Balda, Ana Claudia. "Estudo retrospectivo de casuística, comparativo de metodologia diagnóstica e de avaliação de eficácia da griseofulvina e da terbinafina na terapia das dermatofitoses em cães e gatos." Universidade de São Paulo, 2001. http://www.teses.usp.br/teses/disponiveis/10/10136/tde-29072009-090127/.

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As dermatofitoses dos carnívoros domésticos são infecções fúngicas superficiais, causadas habitualmente por dois gêneros fúngicos: Microsporum sp e Trichophyton sp. Trata-se de uma antropozoonose, com importância na saúde pública Objetivou-se: caracterizar a população de cães e gatos acometidos por dermatofitose atendidos no Serviço de Dermatologia do HOVET /USP num período de 27 meses; determinar a valia do exame histopatológico como metodologia diagnóstica; e comparar a eficácia da griseofulvina e da terbinafina na terapia das dermatofitoses. Foram atendidos 76 animais com diagnóstico de dermatofitose, 47,3% pertenciam à espécie fetina e 52,7% à canina O agente etiológico isolado com maior freqüência em caninos e felinos foi Microsporum canis. Não se observou distribuição sazonal. Os cães de raça definida foram os mais acometidos (75,0%), dentre estes, aqueles da raça Yorkshire Temer (23,3%). Os felinos com e sem definição racial igualmente acometidos, porém os Persas (93,7%) foram os mais acometidos dentre aqueles com plena definição. Observou-se que a maioria dos animais infectados apresentava menos de um ano de idade (65,8%). As lesões mais observadas foram: alopecia, eritema, escamas e crostas. A maioria das lesões apresentava configuração circular e estavam localizadas nas regiões cefálicas, de tronco e de membros. O prurido esteve ausente em 50,0% dos caninos e em 88,8% dos felinos. As lesões dos cães tinham caráter mais inflamatório. O exame histopatológico mostrou-se pouco sensível (28,6%) e com alto número de falsos negativos (71,4%). A griseofulvina (5Omg/kg/dia) foi eficaz em l00,0% dos casos, sem acarretar efeitos colaterais, com média de tempo para cura de 41 dias. Já a terbinafina na dose de cinco mg/kg/dia, apresentou eficácia de 81,8%, sem induzir efeitos colaterais e com êxito terapêutico em 21 dias. Demonstrou-se assim, que a dose de 20 mg/kg/dia demonstrou a mesma eficácia que a dose de cinco, porém, com efeitos colaterais em 16,6% dos animais tratados, com tempo médio para cura de 33 dias. Demonstrou-se que a terbinafina é uma boa alternativa terapêutica, porém, a griseofulvina ainda se constitui na droga de eleição para o tratamento das dermatofitoses de caninos e felinos.
Dermatophytosis in domestic carnivorous are superficial infections caused mainly by two genus of fungus: Microsporum sp and Trichophyton sp. This disease is an anthropozoonosis important for public health. The goals of this study were: characterize the population of cats and dogs with dermatophytosis treated in the Dermatology Service of HOVET FMVZ/USP in a period of 27 months; evaluate the validity of the histopathological exam as a methodology of diagnosis; and compare the efficacy of griseofulvin and terbinafine in the therapy of the dermatophytosis. Seventy six animals (47,3% were felines and 52,7% were canines) were evaluated in this study. The more frequent isolated etiological agent in canines and felines was Microsporum canis. Seasonality was not observed. The dogs with a defined breed were more predisposed (75,0%) and the Yorkshire Terrier dogs had a higher proportion of positive cultures (23,3%). The felines with or without breed definition got the same frequency, however, the Persians (93,7%) were more predisposed among those of pure breed. It was noticed that the majority of infected animals were under one year of age (65,8%). The most observed lesions were: alopecia, crusts, erythema and scales. The majority of the lesions had a circular form and were found in the cephalic, trunk and limb regions. There was no pruritus in 50,0% of the canines and 88,8% of the felines. The lesions were more inflammatory in dogs. The histopathological exam had a low sensitivity (28,6%) and a high number of false negatives (71,4%).Griseofulvin (50 mg/kg/day) was effective in 100,0% of the cases, with no side effects, the average time for cure was 41 days. The terbinafine used at the dosage of 5 mg/kg/day showed an efficacy of 81,3%, no side effects were observed as well and average time for cure was 21 days. The same efficacy using the dosage of 20 mg/kg/day of terbinafine was observed, although side effects were observed in 16,6% of the animals treated with an average time for cure of 33 days. The present study demonstrated that terbinafine is a good therapeutical alternative, although griseofulvin is still the first choice drug for the treatment of dermatophytosis in dogs and cats.
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Marchini, Julio Flávio Meirelles. "Isolamento e caracterização de gene que confere resistência à terbinafina em leishmania major." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/17/17136/tde-03082008-173958/.

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A amplificação gênica pode ser compreendida como um mecanismo de regulação de expressão protéica em Leishmania. A exposição a concentrações não letais de diferentes drogas isoladamente, como o metotrexato, a primaquina, cloroquina e antimônio levam à amplificação de regiões específicas como as localizadas no cromossomo 6 e no cromossomo 23. Essas linhagens tornam-se resistentes a estas drogas e eventualmente apresentam resistência cruzada a outras. A terbinafina é uma substância sintética utilizada como antifúngico que age pela inibição da esqualeno epoxidase impedindo a síntese de ergosterol, componente da membrana celular de Leishmania. A exposição do parasita à terbinafina leva à amplificação da região H. A fragmentação da região H permitiu delimitar a resistência a 2,8 kb; fragmento T1. Por mutagênese insercional o gene de resistência à terbinafina foi definido e nomeado HTBF. A proteína codificada pelo HTBF possui uma extremidade N-terminal hidrofílica e C-terminal hidrofóbica com quatro alfa-hélices sendo, supostamente, uma proteína integral de membrana. Possui semelhança com a proteína Yip de Saccharomyces cerevisiae, que participa do transporte vesicular do retículo endoplasmático para o complexo de Golgi. O gene HTBF foi detectado em linhagem sensível de L. major e de outras espécies de Leishmania e seu transcrito em linhagens sensíveis e resistentes de L. major. Levantou-se a hipótese de se tratar de locus de resistência a múltiplas drogas já que as regiões amplificadas, mesmo que induzidas por uma determinada droga, podem levar a resistência a outras. A co-transfecção do gene de resistência ao antimonial MRPA no transfectante portador do HTBF levou à diminuição em até cinco vezes da capacidade de resistência ao antimônio. Apesar dos genes de resistência amplificarem juntos na região H, foi constatado que possuem ação contrária. Sendo que a terbinafina interfere na integridade da membrana celular, levantou-se hipótese na qual a resistência envolveria o mecanismo de reparo de membrana. A perda do fenótipo de resistência pela falta de cálcio sugerindo a inativação desse mecanismo é um fenômeno previsto corroborando a hipótese.
Gene amplification can be recognized as a protein regulation mechanism in Leishmania. Exposure to non-lethal concentrations of different drugs in isolated manner, such as, methotrexate, primaquine, chloroquine and antimony drives the amplification of specific regions. Examples for amplified regions are contained in chromosomes six and 23. The strains become resistant to these drugs and eventu-ally to other drugs as well. Terbinafine is a synthetic substance used as an antifungal agent. Its mechanism of action is by squalene epoxidase inhibition, blocking ergosterol synthesis, a cell membrane component in Leishmania. Parasite exposure to terbinafine elicits H region amplification. H region fragmentation allowed resistance delimitation to 2.8kb, T1 fragment. By insertional mutagenesis terbinafine resistance gene was defined and termed HTBF. HTBF coded protein has a hydrophilic N-terminal and a hydrophobic C-terminal containing four alpha-helixes, putatively, an integral membrane protein. It possesses homology to Saccharomyces cerevisiae Yip protein, which takes part in the vesicular transport from the endoplasmic reticulum to Golgi apparatus. HTBF gene was detected in sensitive L. major strains and other Leishmania species and its transcript was detected in both resistant and sensitive L. major strains. We raised the hypothesis of a multiple drug resistance locus, since amplified regions induced by one drug could elicit resistance to a second drug. Co-transfection of MRPA to the HTBF transfectant led to a five-fold decrease to antimonial resistance level. Even though these resistance genes amplify together in the H region, they have antagonizing mechanisms of action. Since terbinafine action disrupts membrane integrity, we raised a hypothesis in which resistance involves enhancement of membrane repair machinery. Loss of phenotype caused by the lack of calcium suggests the inactivation of this machinery is a predicted phenomenon, corroborating the hypothesis.
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Cavalheiro, Ayrton Sydnei. "ATIVIDADE IN VITRO DA TERBINAFINA E ASSOCIAÇÕES SOBRE PYTHIUM INSIDIOSUM." Universidade Federal de Santa Maria, 2009. http://repositorio.ufsm.br/handle/1/8939.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Pythiosis is a granulomatous disease of human and animals that occurs primarily in tropical and subtropical areas of the world. It is caused by an aquatic, fungus-like organism called Pythium insidiosum. The treatment for pythiosis is uncertain, with an unfavorable prognosis for human and animals. Therefore, new possibilities for treatments must be examined. We have evaluated the in vitro activities of terbinafine (0.25 to 32 mg/L) alone and in combination with caspofungin (0.5 to 128 mg/L), miconazole (0.25 to 32 mg/L), fluconazole(0.125 to 64 mg/L), ketoconazole (0.125 to 64 mg/L), amphotericin B (0.25 to 16 mg/L), fluvastatin (0.125 to 64 mg/L), rifampicin (0.25 to 64 mg/L), metronidazole (0.25 to 128 mg/L) and ibuprofen (8 to 2,048) against 17 clinical isolates of P. insidiosum. Antifungal activities were assayed by broth microdilution, based on protocol M38-A for filamentous fungi, adapted to P. insidiosum, as well as the checkerboard method. Synergisms were observed in combinations of terbinafine plus caspofungin (41.18%), fluconazole (41.18%), amphotericin B (41.18%), ketoconazole (29.41%) and miconazole (11.76%). The combinations of terbinafine plus rifampicin and terbinafine plus metronidazole were indifferent for 94.12% of strains. Terbinafine plus ibuprofen was indifferent for 82.35% of strains. Antagonisms were observed in combinations of terbinafine with fluvastatin (35.30%) or rifampicin (5.88%). The combinations of terbinafine plus caspofungin, terbinafine plus fluconazole and terbinafine plus amphotericin B may have significant therapeutic potential for treatment of pythiosis.
Pitiose é uma doença granulomatosa de humanos e animais que ocorre principamente em áreas tropicais e subtropicais de todo o mundo. Ela é causada por um microrganismo aquático semelhante aos fungos chamado Pythium insidiosum. O tratamento para pitiose é incerto, com um prognóstico desfavorável tanto para humanos como para os animais. Com isso, novas possibilidades para tratamentos devem ser examinados. Desta forma, avaliou-se a atividade in vitro da terbinafina (0,25 a 32 mg/L) sozinha e em combinação com caspofungina (0,5 a 128 mg/L), miconazol (0,25 a 32 mg/L), fluconazol (0,125 a 64 mg/L), cetoconazol (0,125 a 64 mg/L), anfotericina B (0,25 a 16 mg/L), fluvastatina (0,125 a 64 mg/L), rifampicina (0,25 a 64 mg/L), metronidazol (0,25 a 128 mg/L) e ibuprofeno (8 a 2.048) frente a 17 isolados clínicos de P. insidiosum. As atividades antifúngicas foram avaliadas por microdiluição em caldo, baseado no protocolo M38-A para fungos filamentosos, adaptado para P. insidiosum, e pela técnica de checkerboard. Sinergismos foram observados nas combinações de terbinafina mais caspofungina (41,18%), fluconazol (41,18%), anfotericina B (41,18%), cetoconazol (29,41%) e miconazol (11,76%). As combinações de terbinafina mais rifampicina e terbinafina mais metronidazol foram indiferentes para 94,12% das cepas. Terbinafina mais ibuprofeno foi indiferente para 82,35% dos isolados. Antagonismos foram observados nas combinações de terbinafina mais fluvastatina (35,30%) ou rifampicina (5,88%). As combinações de terbinafina mais caspofungina, terbinafina mais fluconazol e terbinafina mais anfotericina B podem ter significante potencial terapêutico para o tratamento da pitiose.
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Dias, Fabrício César. "Caracterização de mecanismos de resistência à terbinafina em diferentes espécies de Leishmania." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/17/17136/tde-06052009-093740/.

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O fenômeno de amplificação gênica é um mecanismo de auto-preservação celular observado com freqüência no protozoário parasita Leishmania quando submetido a estímulos negativos como, por exemplo, a presença de drogas. A região H do genoma de Leishmania (Leishmania) major é um dos loci mais estudados que leva à amplificação em resposta a drogas não relacionadas, como a terbinafina. Foram isoladas linhagens de L. (L.) major e Leishmania (Viannia) braziliensis resistentes à terbinafina. Análises por corridas curtas de eletroforese em campo pulsado (PFGE) e Southern blotting revelaram que a resistência observada nestas linhagens não foi gerada pela amplificação do locus H. Sendo assim, a resistência ao inibidor da esqualeno epoxidase está sendo gerada por um outro mecanismo uma vez que outros loci podem estar envolvidos na resistência à terbinafina e através da análise diferencial do perfil de proteínas, os mutantes resistentes apresentaram diferenças na expressão de proteínas. O alvo inicial para a elucidação da resistência à terbinafina nas linhagens selecionadas foi a via de biossíntese de ergosterol. Foram escolhidos os genes da 3-cetoacil-CoA tiolase (ERG10), esqualeno sintase (ERG9 ou SQS1), esqualeno epoxidase (ERG1), oxidoesqualeno-lanosterol ciclase (ERG7) e lanosterol 14-demetilase (ERG11), de L. major e L. braziliensis, além do gene YIP1 de L. braziliensis. Para isso foram sintetizados oligonucleotídeos a partir das seqüências geradas pelo projeto genoma destas espécies depositadas em bancos de dados. Os genes ERG10, SQS1, ERG1, ERG7 e ERG11 de L. major e de L. braziliensis além do YIP1 de L. braziliensis amplificados por PCR foram clonados no vetor pGEM-T Easy, que possibilitou a construção de reagentes para ruptura de todos genes pela inserção da marca HYG e, com exceção do gene ERG7 de L. braziliensis, os genes foram subclonados no vetor pXG1. Fragmentos de restrição dos genes clonados no vetor pGEM-T Easy foram utilizados para analisar o nível de seus transcritos por northern blot. Também verificamos através de corridas curtas de PFGE e análises de Southern, que as linhagens em estudo não apresentam amplificação dos loci em estudo. A participação de genes da via de biossíntese de ergosterol de L. major e L. braziliensis e do gene YIP1 de L. braziliensis na resistência ou susceptibilidade à terbinafina e/ou anfotericina B foi verificada através de experimentos funcionais. Com esse objetivo, os genes YIP1, ERG10 e ERG1 de L. braziliensis foram transfectados na linhagem LB2904 de L. braziliensis, e os genes ERG10, SQS1, ERG1, ERG7 e ERG11 e a ruptura do gene ERG1 pelo cassete HYG de L. major foram transfectados na linhagem LT252 de L. major. Foram realizados experimentos para analisar a susceptibilidade à anfotericina B associada ou não à terbinafina, das linhagens selvagens de L. major e L. braziliensis, e a partir destes experimentos iniciais, foram selecionadas linhagens destas duas espécies resistentes à anfotericina B. Para analisar a possível função regulatória dos elementos RIME 5/2/6 de L. braziliensis, foi feita a amplificação por PCR da repetição invertida LbRIME 5/2/6b que permitiu a clonagem deste fragmento no vetor pGEM-T Easy e a sua ruptura pela marca SAT. A clonagem no vetor pGEM possibilitou a análise da interação de proteínas nucleares à repetição LbRIME 5/2/6b através do gel shift.
Gene amplification is a common phenomenon observed in Leishmania cell lines subjected to drug pressure. The H locus of Leishmania (Leishmania) major is normally found amplified in cell lines selected in unrelated drugs, as terbinafine. We selected cell lines of L. (L.) major and Leishmania (Viannia) braziliensis resistant to terbinafine. Short-run Pulsed Field Gel Electrophoresis (PFGE) and Southern blotting analysis showed that this resistance was not generated by H locus amplification. Resistance to squalene epoxidase inhibiter is being generated by other mechanism once others loci can be involved in the terbinafine resistance and through protein partner differential analysis, mutants resistant showed differences in protein expression. The initial target to terbinafine resistance elucidation in the cell lines selected was ergosterol biosynthesis pathway. We choose genes: 3-ketoacyl-CoA thiolase (ERG10), squalene synthase (ERG9 or SQS1), squalene epoxidase (ERG1), oxidosqualene-lanosterol cyclase (ERG7), and lanosterol 14-demethylase (ERG11), of L. major and L. braziliensis, besides YIP1 gene of L. braziliensis. For this, primers were synthesized using the sequences generated by genome project of these species inserted in gene bank. The genes ERG10, SQS1, ERG1, ERG7 and ERG11 of L. major and of L. braziliensis besides YIP1 of L. braziliensis were amplified by PCR and cloned into pGEM-T Easy vector that enabled all genes disruption by insertion of HYG cassette and, with exception of the ERG7 gene of L. braziliensis, genes were subcloned into shuttle-vector pXG1. Restrictions fragments of these genes were used in Northern analysis to verify the transcripts level. We verified through short-run PFGE and Southern analysis that the resistant cell lines do not show amplification of studied loci. The participation of ergosterol biosynthesis pathway genes of L. major and L. braziliensis and YIP1 gene of L. braziliensis in the resistance to terbinafine was verified in functional experiments. With this objective, the genes YIP1, ERG10 and ERG1 of L. braziliensis were transfected into LB2904 cell line of L. braziliensis, and the genes ERG10, SQS1, ERG1, ERG7 and ERG11 and the ERG1 gene disruption by HYG mark of L. major were transfected into LT252 cell line of L. major. Experiments that analyze the susceptibility to amphotericin B associated or not to terbinafine were performed using the wild type cell lines of L. major and L. braziliensis, and with this initials experiments, we selected cell lines of these two species resistant to amphotericin B. In order to analyze the possible regulatory function of the RIME 5/2/6 elements of L. braziliensis, the repeat LbRIME 5/2/6b was amplified by PCR and cloned into pGEM-T Easy vector and with this clone, the element was disrupted with a SAT cassette. The cloning into vector pGEM enabled to analyze the interaction of the nuclear protein with the repeat LbRIME 5/2/6b through gel shift assay.
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Agathon, Véronique. "Pharmacocinétique et biotransformations du Lamisil R (terbinafine) et de ses 3 principaux métabolites après administration orale à doses croissantes et répétées chez le sujet sain." Paris 5, 1996. http://www.theses.fr/1996PA05P147.

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Ibrahim, MohD, Omer sheikh, Pratyksha Sankhyan, Qaryoute Ayah Al, Abdulrahman Ibrahim, Akilesh Mahajan, Nilesh Mahajan, Mohsen Pourmoteza, and Jason Mckinney. "Terbinafine induced fulminant hepatic failure and patient death." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/asrf/2019/schedule/108.

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A 72 year-old-patient without known past medical history presented to the hospital with worsening cough, dyspnea on exertion, decreased appetite, weight loss for two months. Prior to admission, he was treated with a 10- day course of levofloxacin and prednisone as a case of bronchitis with minimal improvement. Then he started to develop red urine with marked changes in mental status. On physical examination, the patient had notifiable scleral icterus, confusion and abdominal tenderness in the right upper quadrant. On admission his labs were significant for alkaline phosphatase 541, aspartate transaminase 557, alanine transaminase 94, total bilirubin 8.6, lactate 11.7. CT scan of abdomen showed hepatosplenomegaly, mild ascites and trace bilateral pleural effusion. Work up with Viral hepatitis serology, cryptococcal antigen, histoplasma antigen, respiratory virus panel, Epstein Barr virus tests were negative. Anti-nuclear antibodies (ANA) and anti-mitochondrial antibody were also negative. Blood level of amylase, lipase, acetaminophen and alcohol were negative at admission too. The patient was started initially on broad spectrum antibiotics, N-acetyl cysteine empirically and aggressive intravenous fluid hydration. Patient condition rapidly worsened and he developed profound shock requiring mechanical ventilation and started on stress dose steroid and pressor support. Upon further investigation, patient was noted to take terbinafine for toe onychomycosis (day 112). Ferritin level was elevated to 1596 with 93% iron saturation. Ceruloplasmin level was normal. Patient was not a transplant candidate due to multiple organ failure. As per family request, patient was palliatively extubated and died. Terbinafine is a fungicidal drug with activity against dermatophytes including Epidermophyton flccosum and trichophyton rubrum. It works by inhibition of squalene epoxidase with a resultant accumulation of squalene in the fungal cell and killing it as a result. Commonly used orally to treat onychomycosis and other fingernails and toenails infections. Shortly after its introduction to the market, DILI had been reported with elevation with serum aminotransferases elevation that was usually self-limited. Usually presents within first 6 weeks of therapy with either hepatocellular or cholestatic initially with sings of hypersensitivity. Mechanism of injury entails hypersensitivity reaction, though the full pathogenesis was not elucidated yet, but genetic polymorphism is implicated in the variable presentation especially among HLA-A 33:01 allele carriers. Terbinafine DILI resolves usually within 6 months of stopping the medication but can lead to death or need liver transplantation in some cases.
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Taurelle, Valérie. "La terbinafine : pharmacocinétique de la molécule mère et d'un métabolite aprés administration orale unique d'un comprimé à 250 mg, étude de bioéquivalence entre quatre formes galéniques." Paris 5, 1992. http://www.theses.fr/1992PA05P212.

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Brasset, Charlotte. "Lamisil R (Terbinafine), linéarité de la pharmacocinétique de la Terbinafine et de ses trois principaux métabolites à dose unique et à l'état d'équilibre chez le volontaire sain." Paris 5, 1996. http://www.theses.fr/1996PA05P146.

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Books on the topic "Terbinafin"

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Asia-Pacific Symposium on Lamisil (1993 Vienna, Austria). Terbinafine in the treatment of superficial fungal infections: Proceedings of the Asia-Pacific Symposium on Lamisil : proceedings of a satellite symposium held during the Dermatology 2000 congress in Vienna, May 1993. London: Royal Society of Medicine Services, 1993.

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Lamisil: The Evidence. Informa Healthcare, 2001.

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Iverson, Suzanne Leah. In vitro and in vivo investigations into idiosyncratic drug reactions: the role of reactive metabolites produced by the target tissue in terbinafine-induced cholestatic hepatitis and antipsychotic-induced agranulocytosis. 2002, 2002.

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Iverson, Suzanne Leah. In vitro and in vivo investigations into idiosyncratic drug reactions: The role of reactive metabolites produced by the target tissue in terbinafine-induced cholestatic hepatitis and antipsychotic-induced agranulocytosis. 2002.

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Book chapters on the topic "Terbinafin"

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Jones, Thomas C., and Violette V. Villars. "Terbinafine." In Chemotherapy of Fungal Diseases, 483–503. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-75458-6_23.

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Cuenca-Estrella, Manuel, and Juan Luis Rodriguez-Tudela. "Terbinafine." In Aspergillosis: From Diagnosis to Prevention, 317–25. Dordrecht: Springer Netherlands, 2009. http://dx.doi.org/10.1007/978-90-481-2408-4_19.

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Pappas, Peter G. "Terbinafine." In Essentials of Clinical Mycology, 113–19. New York, NY: Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-6640-7_7.

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Monod, Michel, Marc Feuermann, and Tsuyoshi Yamada. "Terbinafine and Itraconazole Resistance in Dermatophytes." In Dermatophytes and Dermatophytoses, 415–29. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-67421-2_20.

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de Wolff, F. A. "Hoe vaak moet de leverfunctie worden gecontroleerd bij gebruik van terbinafine?" In Vademecum permanente nascholing huisartsen, 2009–10. Houten: Bohn Stafleu van Loghum, 2006. http://dx.doi.org/10.1007/978-90-313-8808-0_1067.

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"Terbinafin." In Checkliste Arzneimittel A–Z, edited by Detlev Schneider and Frank Richling. Stuttgart: Georg Thieme Verlag, 2013. http://dx.doi.org/10.1055/b-0034-82781.

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"Terbinafine." In Meyler's Side Effects of Drugs, 745–54. Elsevier, 2016. http://dx.doi.org/10.1016/b978-0-444-53717-1.01516-x.

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Waugh, Christine D. "Terbinafine." In xPharm: The Comprehensive Pharmacology Reference, 1–4. Elsevier, 2007. http://dx.doi.org/10.1016/b978-008055232-3.62729-1.

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Bylund, David B. "Terbinafine ☆." In Reference Module in Biomedical Sciences. Elsevier, 2018. http://dx.doi.org/10.1016/b978-0-12-801238-3.97744-4.

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"Terbinafine." In Dermatology Therapy, 562. Berlin, Heidelberg: Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/3-540-29668-9_2659.

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Conference papers on the topic "Terbinafin"

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Rencber, Seda, and Sakine Tuncay Tanrıverdi. "Terbinafine Hydrochloride Loaded PLGA Nanoparticles for Topical Administration." In The 3rd World Congress on Recent Advances in Nanotechnology. Avestia Publishing, 2018. http://dx.doi.org/10.11159/nddte18.112.

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HIPLER, U. CH, CH SCHROETER, B. HIPLER, and U. WOLLINA. "INHIBITORY EFFECT OF TERBINAFINE ON REACTIVE OXYGEN SPECIES (ROS) GENERATION BY CANDIDA ALBICANS." In Proceedings of the 11th International Symposium. WORLD SCIENTIFIC, 2001. http://dx.doi.org/10.1142/9789812811158_0099.

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Kondoros, Balázs Attila, and Zoltán Aigner. "Physicochemical characterization and dissolution studies of terbinafine hydrochloride–cyclodextrin complexes prepared by solvent-free co-grinding." In II. Symposium of Young Researchers on Pharmaceutical Technology,Biotechnology and Regulatory Science. Szeged: Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Faculty of Pharmacy, 2020. http://dx.doi.org/10.14232/syrptbrs.2020.op23.

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Chien, Ming-Hsien, Shun Fa Yang, and Wen Sen Lee. "Abstract 3040: Terbinafine inhibits oral squamous cell carcinoma growth through anti-cancer cell proliferation and anti-angiogenesis." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-3040.

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Reports on the topic "Terbinafin"

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Terbinafine is probably first choice oral drug for fungal toenail infection. National Institute for Health Research, October 2017. http://dx.doi.org/10.3310/signal-000494.

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