Dissertations / Theses on the topic 'Terme simple'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 39 dissertations / theses for your research on the topic 'Terme simple.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.
Leger, Julien. "Un modèle d'ascendance convective simple prenant en compte explicitement le terme de pression non-hydrostatique." Phd thesis, Toulouse, INPT, 2018. http://oatao.univ-toulouse.fr/23929/1/LEGER_Julien.pdf.
Full textBoulaknadel, Siham. "Traitement Automatique des Langues et Recherche d'Information en langue arabe dans un domaine de spécialité : Apport des connaissances morphologiques et syntaxiques pour l'indexation." Phd thesis, Université de Nantes, 2008. http://tel.archives-ouvertes.fr/tel-00479982.
Full textCormier, Bettie. "Toxicité des microplastiques chez les poissons, au-delà de simple vecteurs de polluants?" Thesis, Bordeaux, 2020. http://www.theses.fr/2020BORD0036.
Full textDuring the last decades, plastics have gained interest from media, public and scientists. Plastics have been categorized as emerging pollutants particularly in the marine environment due to their ubiquity and persistence, particularly microplastics (< 5 mm, MPs). Numerous studies reported the occurrence of MPs in the marine environment (surface water, sediments). However, neither there exist standardized nor harmonized methods to evaluate their potential toxicity and their role as vector of hazardous chemicals into organism. This thesis had three main objectives, (1) the investigation of sorption of chemicals models on MPs, (2) the study of the toxic potential of these sorbed chemicals on zebrafish and (3) the characterization and the study of the toxicity of environmental MPs. The first part of the thesis aimed at the investigation of the sorption processes of three model pollutants - perfluorooctanesulfonic acid (PFOS), benzo[a]pyrene (BaP) and oxybenzone (BP3) - on pristine MPs using different sizes and polymer types. The second part studied the vectorization of the three compounds sorbed on MPs toward zebrafish (Danio rerio) embryos, juveniles and adults through direct or trophic exposures, and their toxicities. The third part investigated the toxicity of environmental samples of MPs from two sandy beaches (Guadeloupe Island, France), using the same procedure as above, as well as the characterization of additives and adsorbed chemicals through a non-target approach. Study of pollutants sorption demonstrated differences in pattern (e.g. kinetics, sorption efficiency), depending on size particles and chemical used. Potential adverse effects of MPs associated with chemicals were investigated in zebrafish embryos using OECD 236 guideline and by using a chronic exposure from larvae or juveniles up to 5-months old adults through trophic exposure. Molecular and individual toxicological endpoints were monitored during exposure. Main findings were the low acute toxicity of MPs on early life stages (embryos and larvae) exposed to particles, organic extracts or leachates. Nevertheless, the ingestion of MPs by juveniles and adults led to a significant long-term toxicity for all tested MPs albeit with different intensity according to the spiked chemicals and to the environmental samples. Deleterious effects included growth alteration, reprotoxicity, behavioral disturbances as well as hyperactivity observed in offspring of exposed fish. In conclusion, the present work revealed that (1) MPs may play a role in the vectorization of pollutants and (2) may induce significant sublethal effects in juveniles of zebrafish chronically fed with pristine MPs or MPs artificially spiked with pollutants. Same conclusions were observed (3) with environmental MPs
Hmouda, Bassem. "Étude détaillée du deuxième terme de l'approximation de Born : applications à l'ionisation de l'atome d’Hydrogène et à la double ionisation de l'atome d’Hélium par impact d’électrons et de positrons." Thesis, Université de Lorraine, 2014. http://www.theses.fr/2014LORR0383/document.
Full textThe perturbative methods, such as Born approximation, are necessary to solve the problems concerning the ionization of atoms and molecules by electrons or positrons impacts. In order to use Born approximation in an optimized way, we tested it on the simplest atom « Hydrogen » by using a basis of large amount of intermediate states (294) and complete numerical calculation without using the closure approximation whose application needs the introduction of a parameter which is the excitation mean value. Our results proved a significant agreement with the experiment particularly for small energies of the ejected electrons. We also proved an important contribution of the continuum (represented by the pseudo-states), and particularly the dipolar transition. For the double ionization of Helium atom, we applied the same methodology of complete calculation by including 20 intermediate states and pseudo-states and by using a configuration interaction wave function, we found that for high incident energy (5 keV) the effect of the second term of Born is almost zero. However, the application of the « SBA » with the closure approximation by using the fundamental state and the first excited states show a slight difference relative to the « FBA » particularly outside the transfer region. In case of low incident energy (601 eV), it was expected a crucial effect of the « SBA » especially that previous studies of (e, 3-1e) of Helium show a significant shift of the main peak relative to the « FBA ». So we can say that 20 intermediate states are not enough and the application of the « SBA » needs more states
Fanget, Muriel. "Les stratégies de résolution d'opérations arithmétiques simples : un nouveau paradigme." Phd thesis, Université Blaise Pascal - Clermont-Ferrand II, 2010. http://tel.archives-ouvertes.fr/tel-00669686.
Full textP'Kla, Abalo Di Benedetto Hervé. "Caractérisation en compression simple des blocs de terre comprimée (BTC) application aux maçonneries "BTC-Mortier de terre /." Villeurbanne : Doc'INSA, 2004. http://docinsa.insa-lyon.fr/these/2002/pkla/index.html.
Full textP'Kla, Abalo. "Caractérisation en compression simple des blocs de terre comprimée (BTC) : application aux maçonneries "BTC-Mortier de terre"." Lyon, INSA, 2002. http://theses.insa-lyon.fr/publication/2002ISAL0037/these.pdf.
Full textCompressed earth blocks (CEB) masonry make it possible to build individual houses at a low environmental (and economic for poor countries) cost because of the use of local materials. Moreover, this step has a positive social and economic impact since it supports the direct human work of construction, contrary to the current type of construction based on the industrialization of the material production. Architecture used in CEB construction is adapted to a material which should support only compression stress. This thesis is a contribution to the formalization of CEB masonries buildings design which concerns, until now, only the code of practice. Only masonry behaviour under vertical compression load is analysed. As a preliminary, the CEB which constitute the principal component of masonry were studied. The various compression tests used for CEB were presented and criticized. Compression test on two half built blocks remains relevant. It was shown that three points bending test can also give compressive strength of CEB. The second component of masonry is earth mortar stabilized with cement. There exists very little information on these mortars with strong clay content (between 5 and 20 % and more). An overview of mortar tests able to be used for earth mortar is made and lead to some propositions for future studies. Finally, two types masonry samples were tested under vertical compression load ; 1m2 masonry and three blocks bpnded samples. The Euroeode 6 formula for masonry compressive strength assessment is used and the results compared with our. Experimental data
Roth, Bailey Heather. "Contribution of strategy use to performance on complex and simple span tasks." [Kent, Ohio] : Kent State University, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=kent1247583267.
Full textTitle from PDF t.p. (viewed Mar. 8, 2010). Advisor: John Dunlosky. Keywords: Working memory; short-term memory; secondary memory; strategy use; fluid intelligence. Includes bibliographical references (p. 56-59).
Simola, Markku. "Allergic and non-allergic rhinitis : a long-term clinical follow-up study." Helsinki : University of Helsinki, 2001. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/simola/.
Full textMeinshausen, Malte A. "Long-term chlorine loading prediction SiMCeL /." Zurich : IACETH, 2001. http://e-collection.ethbib.ethz.ch/show?type=dipl&nr=22.
Full textNakayama, Masataka. "The problems of serial order in language:Clustering, context discrimination, temporal distance, and edges." Kyoto University, 2015. http://hdl.handle.net/2433/200480.
Full text草刈, 圭一朗, Keiichirou Kusakari, 正彦 酒井, and Masahiko Sakai. "Enhancing Dependency Pair Method using Strong Computability in Simply-Typed Term Rewriting." Springer-International, 2007. http://hdl.handle.net/2237/11112.
Full textSAKAI, Masahiko, and Keiichirou KUSAKARI. "Static Dependency Pair Method for Simply-Typed Term Rewriting and Related Technique." Institute of Electronics, Information and Communication Engineers, 2009. http://hdl.handle.net/2237/14975.
Full textKlein, Juliette S. "Preschoolers' performance on simple two- and three-term arithmetic problems, working memory constraints and conceptual understanding." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0017/MQ47049.pdf.
Full textToljamo, K. (Kari). "Gastric erosions – clinical significance and pathology:a long-term follow-up study." Doctoral thesis, Oulun yliopisto, 2012. http://urn.fi/urn:isbn:9789514298042.
Full textTiivistelmä Eroosiot ovat mahalaukun pinnallisia limakalvovaurioita. Niitä pidetään vaarattomina lukuun ottamatta niihin liittyvää verenvuototaipumusta. Niiden etiologiaa, histopatologiaa ja taudinkulkua ei tunneta. Ei myöskään tiedetä eroosiopotilaiden mahan limakalvon tulehduksen kulkua. Tämän tutkimuksen tavoitteena oli selvittää mahalaukun eroosioiden kliininen merkitys ja patologia pitkäkestoisena seurantatutkimuksena. Alkujaan 117 potilasta ja 117 kontrollihenkilöä tutkittiin vuosina 1974–1981, ja seurantatutkimus tehtiin vuonna 1996. Selvitimme helikobakteerin ja Herpes simplex -viruksen (HSV) aiheuttamien infektioiden, tulehduskipulääkkeiden (NSAID) ja alkoholin käytön, sekä tupakoinnin esiintymistä. Lisäksi tutkimme histopatologisesti mahalaukun limakalvoa. Lopulta oli 52 potilaan ja 66 kontrollihenkilön aineisto käytettävissä. Seurantakäynnillä 39 prosentilla potilaista oli yhä mahalaukun eroosioita, kun taas kontrolliryhmästä vain 11 prosentilla oli kehittynyt eroosioita. Helikobakteeri -infektoituneilla maha- tai pohjukaissuolen haava/arpi oli yleisempää eroosioryhmässä (17 %) kuin kontrolleilla (4 %), mutta muuten ei esiintynyt lisääntynyttä sairastuvuutta tai kuolleisuutta. Tulehdus oli aktiivisempaa eroosioissa kuin viereisellä limakalvolla, ja tämä tulehdus liittyi korkeisiin HSV-vasta-ainetasoihin, helikobakteeri-infektioon ja NSAID:n käyttöön. Korkeat HSV-vasta-ainetasot ennustivat eroosioiden pysyvyyttä. Ensimmäisellä käynnillä aktiivinen tulehdus eroosioissa oli voimakkaampaa niillä helikobakteeri-infektoituneilla, joilla eroosiot olivat pysyviä kuin niillä, joilla eroosiot eivät uusineet. Helikobakteeri-infektoituneilla eroosiopotilailla mahalaukun runko-osan limakalvon tulehdus oli aluksi vähemmän aktiivista kuin vastaavilla kontrolliryhmän henkilöillä, mutta ajan myötä mahalaukun corpusosan limakalvon tulehdus voimistui vain eroosioryhmällä. Limakalvotulehdus ei edennyt helikobakteeri-infektoitumattomilla henkilöillä. Tulokset osoittavat, että merkittävä osa mahalaukun eroosioista on kroonisia/toistuvia, mutta enimmäkseen ilman vakavia komplikaatioita. Kuitenkin helikobakteeri-infektoituneilla eroosiopotilailla on merkittävä riski saada maha- tai pohjakaissuolen haava. HSV- infektio liittyy merkittävään osaan kroonisia mahalaukun eroosioita. Paikallisella tulehdusaktiivisuudella, jota HSV ja NSAID:n käyttö muokkaavat, saattaa olla tärkeä rooli eroosioiden synnyssä ja niiden kroonistumisessa. Eroosiopotilailla on samanlainen mahalaukun limakalvon tulehduksen jakauma kuin pohjakaissuolihaavaa sairastavilla
Tran, Thai Thanh, Quang Xuan Ngo, Hieu Hoang Ha, and Nhan Phan Nguyen. "Short-term forecasting of salinity intrusion in Ham Luong river, Ben Tre province using Simple Exponential Smoothing method." Technische Universität Dresden, 2019. https://tud.qucosa.de/id/qucosa%3A70822.
Full textXâm nhập mặn có thể gây tác động xấu đến đời sống con người, tuy nhiên nó hoàn toàn có thể dự báo được. Cho nên, một điều quan trọng là tìm được phương pháp kỹ thuật phù hợp để dự báo và giám sát xâm nhập mặn trên sông. Trong bài báo này, chúng tôi sử dụng phương pháp Simple Exponential Smoothing để dự báo xâm nhập mặn trên sông Hàm Luông, tỉnh Bến Tre. Kết quả cho thấy mô hình dự báo phù hợp cho các vị trí An Thuận, Sơn Đốc, và Phú Khánh. Tuy nhiên, các vị trí Mỹ Hóa, An Hiệp, và Vàm Mơn có thể tìm các phương pháp khác phù hợp hơn. Phương pháp Simple Exponential Smoothing rất dễ ứng dụng trong quản lý nguồn nước dựa vào việc cảnh báo xâm nhập mặn.
Sjölander, Johansson Jakob Andreas. "”Obligation”, ”Ought” and ”Can”." Thesis, Umeå universitet, Institutionen för idé- och samhällsstudier, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-179014.
Full textDen här uppsatsen kritiserar den berömda “”bör” implicerar “kan””-principen, (här tolkad som “konceptuell implikation), på så vis att principens viktigaste punkt är falsk, nämligen idén att det inte kan finnas några ouppnåbara plikter. Uppsatsens första del undersöker användningen, historien och litteraturen bakom ämnet, samt formuleringen av principen. Den andra delen presenterar huvudargumentet, riktat mot ””bör” implicerar ”kan”” som en konceptuell sanning. Argumentet fungerar på så vis att det måste vara möjligt att dela upp meningen i termen ”borde/bör” i komponenter, komponenter som måste vara kapabla att fungera även på egen hand. Resultatet blir att vi inte kan dra slutsatsen att en del av termen måste försvinna (såsom dess moraliska innehåll) bara för att en annan del av termen (såsom ”kan”) gör det. Slutligen, i den tredje delen, så behandlar vi några vanliga argument och intuition som förs fram till principens försvar, och summerar texten.
Bornet, Benjamin. "Détermination de la nature moléculaire de marqueurs inter-microsatellitaires ou ISSR (Inter Simple Sequence Repeat) et utilisation pour l'identification variétale et l'analyse des relations phénétiques." Brest, 2002. http://www.theses.fr/2002BRES2003.
Full textLaguna, Merley da Silva Conrado. "Extração automática de termos simples baseada em aprendizado de máquina." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/55/55134/tde-11082014-103430/.
Full textText Mining (TM) aims at discovering innovating knowledge in unstructured texts. The extraction of terms that represent that texts of a specific domain is one of the most important steps of TM, since the results of the overall TM process will mostly depend on the quality of these terms. In this thesis, we consider terms as lexical units used to assign concepts in thematically restricted scenarios. The term extraction task may use approaches such as: statistical, linguistic, or hybrid. Typically, statistical methods are the most common for Text Mining. These methods are computationally less expensive than the linguistic ones, however their results tend to be less human-interpretable. Both methods are not often capable of identifying differences between terms and non-terms. For example, statistical methods may not identify terms that have the same frequency of non-terms and linguistic methods may not distinguish between terms that follow the same patterns of non-terms. One solution to this problem is to use hybrid methods, combining the strategies of linguistic and ststistical methods, in order to attenuate their inherent problems. Considering the features of the term extraction methods, in this thesis, we investigated statistical melhods, ways of obtaining linguistic knowledge, and hybrid methods for extracting simple terms (only one radical, with or without the affixes) for the Braziian Portuguese language. We evaluated, in term extraction, four new hybrid measures (tvq, tv, and comGram) originally proposed for other tasks; and two of them (tvq and tv) were considered relevant for this task. e proposed four new hybrid measures(n_subs., n_adj., n_po, and n_verb); and there of them (n_subst., n_adj., and n_po) were helpful in the term extraction task. Typically, the extraction methods select term candidates based on some linguistic knowledge. After this process, they apply measures or combination of measures (and/or heuristics) to these candidates in order to generate a ranking. The higher the candidates are in the ranking, the better the chances of being terms. To decide up to which position must be considered in this ranking normally, a domain expert and/or terminologist manually or semiautomatically analyse the ranking. The first motivation of this thesis is to automate how to choose the candidates during the term extraction process. The second motivation of this research is to minimize the high number of candidates present in the term extraction. The high number of candidate, caused by the large amount of words in a corpus, could increase the time complexity and computational resources for extracting terms. The third motivation considered in this research is to improve the state of the art of the automatic simple term extraction for Brazilian Portuguese since the results of this extraction (F-measure = 16%) are still low when compared to other languages like English (F-measure = 92%) and Spanish (F-measure =68%). Given these motivations, we proposed the MATE-ML method (Automatic Term Extraction Based on Machine Learning), which aims to automatically extract simple terms using the machine learning techniques. MATE-ML method suggests the use of filters to reduce the high number of term candidates during the term extraction task without harming the domain representation. Thus, we believe the extractors may generate smaller candidate lists, requiring less time to evaluate these candidates. The MATE-ML method was instantiated in two approaches.: (i) ILATE (Inductive Learning for Automatic Term Extraction),. which uses the supervised inductive classification to label term candidates, and (ii) TLATE (Trnasductive Learning for Automatic Term Extraction), which uses transductive semi-supervised classification to propagate the classes from labeled candidates to unlabeled candidates. Using transductive learning in term extraction and using, at the same time, a rich set of candidate features belonging to different levels of knowledge (linguistic,statistical, and hybrid) are also considered as contributions. In this thesis, we discuss the advantages and limitations of these two proposed approaches. We emphasize taht the use of these approaches usually with higher precision (the best case is above of 81%), high coverage results (the best case is above of 87%), and good F-measure value (maximum of 41%) considering three corpora of different domains in the Brazilian Portuguese language
Khoory, Haifa. "The feasibility of transferring cells from archived buccal swabs to FTA card for long term and simple storage of forensic samples." University of Western Australia. Centre for Forensic Science, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0088.
Full textKUSAKARI, Keiichirou. "Higher-Order Path Orders Based on Computability." Institute of Electronics, Information and Communication Engineers, 2004. http://hdl.handle.net/2237/14973.
Full textCHIBA, Yuki, and Keiichirou KUSAKARI. "A Higher-Order Knuth-Bendix Procedure and Its Applications." Institute of Electronics, Information and Communication Engineers, 2007. http://hdl.handle.net/2237/14974.
Full textKUSAKARI, Keiichirou, Masahiko SAKAI, and Toshiki SAKABE. "Primitive Inductive Theorems Bridge Implicit Induction Methods and Inductive Theorems in Higher-Order Rewriting." IEICE, 2005. http://hdl.handle.net/2237/9580.
Full textCai, S. "Construction of a herpes simplex virus type 1 derived vector for targeted long term gene expression in the mammalian nervous system." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597211.
Full textBarreiro, Susana Miguel. "Development of forest simulation tools for assessing the impact of different management strategies and climatic changes on wood production and carbon sequestration for Eucalyptus in Portugal." Doctoral thesis, ISA/UTL, 2012. http://hdl.handle.net/10400.5/5216.
Full textThe present work had as main objective developing tools capable of simulating the evolution of Eucalyptus globulus forests in Portugal taking into account disturbance factors, such as market demands, hazards occurrence, land use changes, forest management and/or climate changes. Some conceptual work was done concerning the definition of different forest management alternatives while at the same time the E. globulus current management was described. SIMPLOT, a regional simulator based on national forest inventory plots was developed and validated. This simulation tool, mainly driven by wood and biomass demands, takes into account the occurrence of hazards, land use changes and the changes between different forest management alternatives allowing accessing its long-term impacts, namely on wood production and carbon sequestration. Some of the empirical growth models available for this species in Portugal were integrated into this simulator. However, the need to forecast the growth of highly stocked stands managed for bioenergy lead to the development of a new model. In order to account for climate changes, a process-based model was required. Therefore, the applicability of 3PG process-based model at a regional scale was tested for planted and coppice stands. Two forest level simulators, 3PG-Out+ and GLOBULUS, were developed along this study.
Zaidi, Zahia. "Recherches sur les modalités de l'interdépendance nutritionnelle entre vers de terre et microflore dans la savane guinéenne de Lamto (Côte d'Ivoire) : esquisse d'un système interactif." Paris 11, 1985. http://www.theses.fr/1985PA112229.
Full textThe geophagous species predominate within the Lumbricidae communities in the tropical savanna of Lamto (Ivory Coast). Their activity is momentous : 1000 T of earth pass through their digestive duct/ha/year, which is equivalent to a layer of 8. 6 cm. 30 T of castings are rejected at the surface, which shapes out a void amidst the sail equivalent to 35 m³/ha. In order to delineate the role of Millsonia anomala (Megascolecidae, Oligochaeta) in the soil compartment, samples brought to pF 2. 5 (14 %) were enriched in composts (1 %) bath aerobes and anaerobes of leaves and roots of Loudetia simplex. In vitro breeding showed the effect on the worms feeding of those different organic substrates. Whereas roots are a poor nutriment, leaves allow a thriwing growth, with notable differences according to the degree of compost maturation. Intake, indeed, increases when the nutritive quality of the latter decreases. Consequently, one supposes a conclusive role of the water-soluble fraction. To verify this hypothesis, sail was enriched, in another breeding series, with various doses of water-soluble extracts of Loudetia leaves. This assay confirms what had been laid out. The castings produced proved to be richer in water-soluble substances than the ingested sail, when this one is but little endowed. At the same time, their respiratory activity was more intense. The reverse is true when hydrosolubles are plentiful in the sail taken in. One construes that the worms draw their subsistence from the sail organic matter water-soluble fraction, which they work up jointly to the microbes. However, one observes all the stages between slackening and activation of the microflora, according to the conditions of the nutritional competition. Relations between wormsand microbes appear to be complex. Worms act upon the microflora, mainly by way of the mucus secreted, when the latter acts upon the worm by means of the water-soluble compounds born of its metabolic activity. Microbial activity, measured at the time of the moving on of the sail within the worms digestive duct, asserts the results obtained by means of the breedings. It reflects moreover the intervention of the sorptive capacity of the ingested mineral colloid, bath towards substrates and enzymes as well as microorganisms. Summing up, this investigation brings forth clues towards a better apprehension of the worms/microbes mutual system and yields ways and means to a modelisation of worm, organic matter and microbes interactions. These interdependency relations bear partly upon the tropical savanas fertility. Their study, therefore, delivers a key to a rational exploitation of that ecosystem's agricultural resources
Jost, Stefanie Theresa [Verfasser], Simone [Gutachter] Vossel, and Josef [Gutachter] Kessler. "Long-term effects of deep brain stimulation on non-motor symptoms in Parkinson’s disease / Stefanie Theresa Jost ; Gutachter: Simone Vossel, Josef Kessler." Köln : Universitäts- und Stadtbibliothek Köln, 2021. http://d-nb.info/1239811608/34.
Full textJunior, Vanderley Alves Ferreira. "Equações de quarta ordem na modelagem de oscilações de pontes." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/55/55135/tde-07072016-165823/.
Full textFourth order differential equations appear naturally when modeling oscillations in elastic structures such as those observed in suspension bridges. Two models describing oscillations in the roadway of a bridge are considered. In the one-dimensional model we study finite space blow up of solutions for a class of fourth order differential equations. The results answer a conjecture presented in [F. Gazzola and R. Pavani. Wide oscillation finite time blow up for solutions to nonlinear fourth order differential equations. Arch. Ration. Mech. Anal., 207(2):717752, 2013] and imply the nonexistence of beam oscillation given by traveling wave profile with low speed propagation. In the two-dimensional model we analyze a nonlocal equation for a thin narrow prestressed rectangular plate where the two short edges are hinged and the two long edges are free. We prove existence and uniqueness of weak solution and we study its asymptotic behavior under viscous damping. We also study the stability of simple modes of oscillations which are classified as longitudinal or torsional.
Lachet, Corinne. "Observation des séismes en milieux urbains : méthodes simples d'étude des effets de site et de simulation des mouvements forts." Phd thesis, Grenoble 1, 1996. http://www.theses.fr/1996GRE10236.
Full textJoussain, Charles. "Construction and validation of HSV-1 vectors with selective and long-term expression in bladder afferent neurons for gene therapy of neurogenic detrusor overactivity. : A translational approach Botulinum Neurotoxin Light Chains Expressed by Defective Herpes Simplex Virus Type-1 Vectors Cleave SNARE Proteins and Inhibit CGRP Release in Rat Sensory Neurons Development and assessment of herpes simplex virus type 1 (HSV-1) amplicon vectors with expression from sensory neuron-selective promoters. Construction and properties of replication-incompetent HSV-1 recombinant vectors expressing transgenic botulinum toxins in primary cultures of human sensory neurons and displaying long-term expression in vivo. Therapeutic escalation for the neurogenic bladder in SCI patients : A bicentric study real life experience Long-term outcomes and risks factors for failure of intradetrusor onabotulinumtoxin A injections for the treatment of refractory neurogenic detrusor overactivity." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLV057.
Full textFifty to 80% of patients with traumatic spinal cord injury (SCI) undergo urinary incontinence episodes, mostly related to neurogenic detrusor overactivity (NDO). NDO is characterized by uninhibited detrusor contractions during the bladder-filling phase which could lead to a significant increase in bladder pressures, especially when associated to sphincter-destrusor-dyssynergia, leading to uro-nephrological complications. The main goal of NDO management following SCI is to achieve regular and complete bladder emptying, avoiding high intra-detrusor pressure and maintaining continence, in order to improve patients’ quality of life and to prevent renal failure. The current management is well characterized and relies on pharmacotherapy acting primarily at the level of efferent motor micturition reflex branch, thus allowing bladder filling at low pressure. First line treatment relies on oral antimuscarinics, often associated to clean intermittent bladder self-catheterization. When patients are refractory to antimuscarinics, injection of botulinum toxin A into the detrusor is proposed. However, despite their efficacy, these treatments fail to persist in the long term, leading to a third-line surgical treatment, which consists in cystoplasty augmentation or sacral neuromodulation. The Brindley technique, which consist in a sacral deafferentation of bladder posterior roots associated to an electrical stimulation, on demand, of anterior roots is a promising alternative, but remains seldom performed because of the complex surgical procedure required. NDO results from the emergence, secondary to neuronal plasticity following SCI, of an abnormal micturition reflex mediated by bladder afferent C-fibers, conveying aberrant sensory information to the spinal cord. The aim of the team where I developed my work is to silence these bladder afferent C-fibers in order to abolish the impaired spinal micturition reflex after SCI. In a second time, micturition would be fired, on demand, by electric stimulation of the bladder efferent neurons. My work consisted in developing the tools and methods required for such molecular deafferentation. Accordingly, I constructed replication-incompetent HSV-1 vectors conceived to deliver a therapeutic transcription cassette, consisting in the light chains of botulinum toxin (BoNT-LC) driven by the human version of the promoter of the gene encoding calcitonin gene-related protein (hCGRP), to achieve sensory neuron-selective transgenic expression. The transcription cassette was inserted into the LAT locus of the HSV-1 genome, the only region of the virus genome that remains transcriptionally active during latent infection. These vectors have been assessed (i) in vitro, on cell lines of neural origin and on primary cultures of rat embryonic and adult sensory neurons, and on primary cultures of adult human sensory and sympathetic neurons, (ii) ex vivo, on organotypic cultures of sensory, sympathetic and parasympathetic ganglia from adult rats, and (iii) in vivo, in sensory ganglia following infection at the hind footpad of adult rats.Our results indicate that (i) the vectors express functional BoNT-LC, thereby cleaving proteins of the SNARE complex in rat and human sensory neurons and inhibiting release of the neuromediator CGRP in rat sensory neurons, (ii) the transcription cassette delivered by the vectors display highly selectively expression towards human sensory neurons, as compared to human sympathetic neurons, and (iii) the vectors induced long-term transgenic expression in sensory (DRG) ganglia (at least for three months) following footpad injection. Therefore, the vectors seem to accomplish the three main specifications required for a future gene therapy strategy, allowing to restore urinary continence and micturition without catheterization and without any major surgery. This approach will represent a major breakthrough in the management of NDO in SCI patients with complete and incomplete lesion
Cléry-Melin, Galichon Marie-Laure. "Étude des fonctions neurocognitives dans la dépression : caractérisation de déficits motivationnels et cognitifs, évaluation de leur valeur pronostique Why don't you try harder? An investigation of effort production in major depression Neural mechanisms underlying motivation of mental versus physical effort Psychomotor retardation is a scar of past depressive episodes, revealed by simple cognitive tests Are cognitive deficits in major depressive disorder progressive? A simple attention test in the acute phase of a major depressive episode is predictive of later functional remission Progress in elucidating biomarkers of antidepressant pharmacological treatment response: a systematic review and meta-analysis of the last 15 years Stability of the diagnosis of seasonal affective disorder in a long-term prospective study." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCB218.
Full textHese deficits coexist in the acute phase of a depressive episode and interfere with decision-making and goal-directed behaviors, and the associated feeling of effort. They appear to persist in periods of clinical remission, decreasing the quality of the therapeutic and functional response and lately worsening the prognosis of the disorder. The aim of this work is to identify objectively measurable neurocognitive markers in clinical practice, and to study their association with the prognosis of a depressive episode, in order to better predict remission and potentially to optimize therapeutic prescribing strategies for patients accordingly. The impairment of neurocognitive processes related to reward constitutes a first vulnerability marker for major depressive disorder (MDD): in a study assessing the production of motor effort in order to obtain a reward, depressed patients had a deficit in production of effort, unlike healthy subjects. Such deficit in incentive motivation - a process underpinned by the activation of ventral cortico-striatal circuits in healthy subjects - may constitute a specific dimension of MDD. It participates in the decision-making and action processes impairments and is associated with – and possibly a consequence of- more specifically cognitive deficits. In a study assessing several cognitive functions in a large cohort of depressed patients, the persistence of psychomotor retardation after 6 to 8 weeks of treatment - in patients considered as being in clinical remission - was positively and independently correlated with the number of past depressive episodes, thus constituting a marker of "cumulative" marker of past depressive episodes. Finally, in a literature review on the progressive evolution of cognitive deficits in MDD, we discussed the existence of a “neurotoxic” effect of the lifetime accumulation of depressive episodes on neurocognitive deficits and its consequences on disease prognosis (increased risk of incomplete functional/clinical remission, relapses, evolution towards dementia). One of the main interest in identifying clinical and cognitive markers of vulnerability is to highlight their capacity to predict the course of a depressive episode-or disorder. In a study based on a cohort of more than 500 depressed patients, a measurement of attention (d2 attention test) was able to significantly and independently predict the subsequent course towards complete remission (clinical and functional) and to constitute a trait -marker of depression, easy to use in clinical practice. Other cognitive markers (such as executive functions) have shown high predictive values for therapeutic response, comparable to those provided by imaging or electrophysiology markers, according to the results of a recent meta-analysis, that emphasizes the interest of using them in patient’s follow-up. Finally, in order to better assess the prognosis of depressive disorder, we have shown that Seasonal Affective Disorder (SAD) diagnosis criteria - which nevertheless represents a specific depressive disorder with well-known physiopathology substrates (construction validity) - had a low predictive validity, prompting to consider this disorder as a temporary expression of a mood disorder, rather than a specific disorder. The identification of clinical tools measuring motivational and cognitive deficits in clinical routine and predicting the course of a depressive episode or disorder represents a major challenge in the improvement of personalized therapeutic management and the long-term prognosis in depressed patients
Carreño, Cruz Sahara Iveth. "Analyse de la variation terminologique en corpus parallèle anglais-espagnol et de son incidence sur l'extraction des termes bilingue." Thèse, 2004. http://hdl.handle.net/1866/17658.
Full textMurray, Peter. "Capturing details of short-term synaptic plasticity in simple schemes." 2004. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=95030&T=F.
Full textMurekezi, Gaju Brigitte. "The term spread, inflation and economic activity in a simple model of the monetary transmission mechanism." Thesis, 2008. http://hdl.handle.net/10539/4711.
Full textTlale, Juliet Karabo. "Validation of a simple clinical formula for predicting birth weight in women who are in labour at term." Thesis, 2012. http://hdl.handle.net/10539/11449.
Full textBackground Estimation of fetal weight during labour at term is frequently done to decide if there is a risk of cephalopelvic disproportion or shoulder dystocia. Estimation of fetal weight by clinical palpation has been shown to be as good as ultrasound in labour at term, giving estimates that are correct to within 10% of the birth weight in 60% to 70% of cases. Symphysis-fundal height (SFH) measurement may offer an easier method of fetal weight estimation, but no simple formula is currently available. The objective of this study was to validate a formula calculated from unpublished work done at Chris Hani Baragwanath hospital, where birth weight in g = 100 (SFH in cm – 5) for term intrapartum measurements. In that study, the formula gave estimates correct to within 10% of the birth weight in 67% of cases. Methods This was a prospective cross-sectional study done on women at term with singleton live cephalic presentations at the Charlotte Maxeke Johannesburg Academic Hospital and Chris Hani Baragwanath Hospital. All participants were in the active phase of the first stage of labour. The author performed abdominal palpation, and measured SFH twice, taking the average of the two measurements as the SFH. Maternal heights, weights, membrane status and level of the head were also recorded. The SFH measurements were transformed into estimated birth weights using the formula, and these were compared with the actual birth weights. 7 Results The researcher assessed 294 women, 289 of them being black African. The mean birth weight was 3221 g and the mean SFH was 37 cm, which equated to a mean estimated birth weight, using the formula, of 3200 g. Simple linear regression between SFH and birth weight gave a correlation coefficient (r) of 0.56. The mean percentage error in fetal weight estimation using the formula was 8.7%. Sixty-five per cent of estimations were found to fall within 10% of the actual birth weight. Fetal weight estimates were best (mean percentage error 6.8%) in the birth weight range of 3000 g to 3499 g, and worst at the extremes of term birth weight. Conclusion The birth weight formula was validated in this study, giving very similar results to those found in the original research that described the formula. The formula may be applied by clinicians in environments that serve populations similar to those that participated in this study.
Vaz, Ana Rita Gomes Teixeira. "Efeito da corticoterapia antenatal na morbilidade e mortalidade de recém-nascidos pré-termo simples e gemelares." Dissertação, 2017. https://repositorio-aberto.up.pt/handle/10216/105254.
Full textVaz, Ana Rita Gomes Teixeira. "Efeito da corticoterapia antenatal na morbilidade e mortalidade de recém-nascidos pré-termo simples e gemelares." Master's thesis, 2017. https://hdl.handle.net/10216/105254.
Full textTemme, Sebastian [Verfasser]. "Einfluss des Glykoprotein B aus Herpes-Simplex-Virus-Typ 1 auf die intrazelluläre Verteilung und Exozytose von HLA- Klasse-II-Molekülen / vorgelegt von: Sebastian Temme." 2010. http://d-nb.info/1001171454/34.
Full textVRASPÍR, Roman. "Návrh pracovních listů pro výuku finanční gramotnosti na ZŠ - finanční produkty." Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-371685.
Full text