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Dissertations / Theses on the topic 'Terpene biosynthesis'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Greenhagen, Bryan T. "ORIGINS OF ISOPRENOID DIVERSITY: A STUDY OF STRUCTURE-FUNCTION RELATIONSHIPS IN SESQUITERPENE SYNTHASES." UKnowledge, 2003. http://uknowledge.uky.edu/gradschool_diss/440.

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Plant sesquiterpene synthases catalyze the conversion of the linear substrate farnesyl diphosphate, FPP, into a remarkable array of secondary metabolites. These secondary metabolites in turn mediate a number of important interactions between plants and their environment, such as plant-plant, plant-insect and plant-pathogen interactions. Given the relative biological importance of sesquiterpenes and their use in numerous practical applications, the current thesis was directed towards developing a better understanding of the mechanisms employed by sesquiterpene synthases in the biosynthesis of s

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2

Lehner, Bryan W. "Aggregation Pheromone Biosynthesis and Engineering in Plants for Stinkbug Pest Management." Thesis, Virginia Tech, 2019. http://hdl.handle.net/10919/100605.

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Stinkbugs (Pentatomidae) and other agricultural pests such as bark beetles and flea beetles are known to synthesize terpenoids as aggregation pheromones. Knowledge of the genes and enzymes involved in pheromone biosynthesis may allow engineering of pheromone biosynthetic pathways in plants to develop new forms of trap crops and agricultural practices for pest management. The harlequin bug, Murgantia histrionica, a specialist pest on crucifer crops, produces the sesquiterpene, murgantiol, as a male-specific aggregation pheromone. Similarly, the southern green stink bug, Nezara viridula, a gener

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3

Ly, Thuy Thi Bich [Verfasser], and Rita [Akademischer Betreuer] Bernhardt. "Characterization of CYP264B1 and a terpene cyclase of a terpene biosynthesis gene cluster from the myxobacterium Sorangium cellulosum So ce56 / Thuy Thi Bich Ly. Betreuer: Rita Bernhardt." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2011. http://d-nb.info/1057789291/34.

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4

Molnar, Istvan, David Lopez, Jennifer Wisecaver, et al. "Bio-crude transcriptomics: Gene discovery and metabolic network reconstruction for the biosynthesis of the terpenome of the hydrocarbon oil-producing green alga, Botryococcus braunii race B (Showa)*." BioMed Central, 2012. http://hdl.handle.net/10150/610020.

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BACKGROUND:Microalgae hold promise for yielding a biofuel feedstock that is sustainable, carbon-neutral, distributed, and only minimally disruptive for the production of food and feed by traditional agriculture. Amongst oleaginous eukaryotic algae, the B race of Botryococcus braunii is unique in that it produces large amounts of liquid hydrocarbons of terpenoid origin. These are comparable to fossil crude oil, and are sequestered outside the cells in a communal extracellular polymeric matrix material. Biosynthetic engineering of terpenoid bio-crude production requires identification of genes a

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5

Weisberg, Alexandra Jamie. "Investigations into the molecular evolution of plant terpene, alkaloid, and urushiol biosynthetic enzymes." Diss., Virginia Tech, 2014. http://hdl.handle.net/10919/64408.

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Plants produce a vast number of low-molecular-weight chemicals (so called secondary or specialized metabolites) that confer a selective advantage to the plant, such as defense against herbivory or protection from changing environmental conditions. Many of these specialized metabolites are used for their medicinal properties, as lead compounds in drug discovery, or to impart our food with different tastes and scents. These chemicals are produced by various pathways of enzyme-mediated reactions in plant cells. It is suspected that enzymes in plant specialized metabolism evolved from those in pri

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6

Barra, Lena [Verfasser]. "Studies on the Biosynthesis and Structure Elucidation of Terpene Natural Products by Isotopic Labeling Experiments / Lena Barra." Bonn : Universitäts- und Landesbibliothek Bonn, 2019. http://d-nb.info/1177881667/34.

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7

Nagel, Raimund [Verfasser], Jonathan [Akademischer Betreuer] Gershenzon, Christian [Akademischer Betreuer] Hertweck, and Alain [Akademischer Betreuer] Tissier. "The regular function of isoprenyl diphosphate synthases in terpene biosynthesis / Raimund Nagel. Gutachter: Jonathan Gershenzon ; Christian Hertweck ; Alain Tissier." Jena : Thüringer Universitäts- und Landesbibliothek Jena, 2014. http://d-nb.info/105836037X/34.

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8

Mondal, Prodyut [Verfasser], Jörg Gutachter] Degenhardt, Timo H. J. [Gutachter] [Niedermeyer, and Timothy Francis [Gutachter] Sharbel. "Biosynthesis and regulation of terpene production in accessions of chamomile (Matricaria recutita L.) / Prodyut Mondal ; Gutachter: Jörg Degenhardt, Timo H. J. Niedermeyer, Timothy Francis Sharbel." Halle (Saale) : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2020. http://d-nb.info/1210732033/34.

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9

Mondal, Prodyut [Verfasser], Jörg [Gutachter] Degenhardt, Timo H. J. [Gutachter] Niedermeyer, and Timothy Francis [Gutachter] Sharbel. "Biosynthesis and regulation of terpene production in accessions of chamomile (Matricaria recutita L.) / Prodyut Mondal ; Gutachter: Jörg Degenhardt, Timo H. J. Niedermeyer, Timothy Francis Sharbel." Halle (Saale) : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2020. http://nbn-resolving.de/urn:nbn:de:gbv:3:4-1981185920-330672.

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10

Martinelli, Laure Marie Bernadette. "Étude de la biosynthèse des terpènes et de leur régulation chez Pelargonium x hybridum." Thesis, Lyon, 2020. http://www.theses.fr/2020LYSES010.

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Le genre Pelargonium fait partie de la famille des Geraniaceae et réunit plus de 280 espèces, ainsi que de nombreux hybrides et variétés sélectionnés depuis le 18e siècle. Ces accessions regroupent notamment de pélargoniums commercialisés en tant que plantes ornementales (comme les P. x hortorum) mais également des pélargoniums odorants (comme les P. x hybridum cv rosat) qui sont cultivés pour leur huile essentielle (HE). L’HE de P. rosat est stockée dans des structures glandulaires (trichomes glandulaires) présentes sur les feuilles et se compose principalement de mono- et sesqui-terpénoïdes.

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11

Zhang, Xinming. "Biomimetic assembly of reactive units for the total synthesis of marine natural products from dual biosynthetic origin." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS318.

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Le manuscrit de thèse traite de la synthèse totale de molécules naturelles de structures particulièrement intrigantes. Deux familles de molécules naturelles issues du monde marin ont été ciblées dans ce travail : les halichonadines et les araiosamines.- La famille des halichonadines nous plongent dans le domaine des terpènes d’origine marine. Isolées d’éponges du genre Halichondria, deux structures ont particulièrement retenues notre attention : les halichonadines K et L. En effet, non seulement, ces deux molécules complexes contiennent une partie terpénique de type eudesmane (halichonadine C,

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12

Crocoll, Christoph [Verfasser], Jonathan [Akademischer Betreuer] Gershenzon, Christian [Akademischer Betreuer] Hertweck, and Harro [Akademischer Betreuer] Bouwmeester. "Biosynthesis of the phenolic monoterpenes, thymol and carvacrol, by terpene synthases and cytochrome P450s in oregano and thyme / Christoph Crocoll. Gutachter: Jonathan Gershenzon ; Christian Hertweck ; Harro Bouwmeester." Jena : Thüringer Universitäts- und Landesbibliothek Jena, 2011. http://d-nb.info/1016391315/34.

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13

Schie, Christianus Cornelis Nicolaas van. "Biosynthesis of volatile and hormonal terpenes in tomato." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2007. http://dare.uva.nl/document/40774.

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14

Schwarz, Matthias Kaspar. "Terpen-Biosynthese in Ginkgo biloba : eine überraschende Geschichte /." [S.l.] : [s.n.], 1994. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=10951.

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15

Fowler, D. J. "Biosynthetic studies on the non mevalonate pathway to terpenes." Thesis, Durham University, 2001. http://etheses.dur.ac.uk/3991/.

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Isoprenoids are a class of secondary metabolites that are widely distributed in Nature. This thesis describes the synthesis and feeding of isotopically labelled enriched substrates to elucidate features of a new mevalonate independent pathway to isoprenoids. Chapter 2 describes studies with a whole plant system, Mentha citrata, which produces the monoterpene linalyl acetate, and a bacterium Escherichia coli which produces ubiquinone-8. Feeding experiments with stable isotopically enriched compounds demonstrate that the terpene unit of linalyl acetate is biosynthesised via the mevalonate indepe

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16

Lee, Sungbeom. "EXPLORING THE BIOCHEMICAL AND EVOLUTIONARY DIVERSITY OF TERPENE BIOSYNTHETIC ENZYMES IN PLANTS." UKnowledge, 2008. http://uknowledge.uky.edu/gradschool_diss/587.

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Southern Magnolia (Magnolia grandiflora) is a primitive tree species that has attracted attention because of its horticultural distinctiveness, the wealth of natural products associated with it, and its evolutionary position as a basal angiosperm. Terpenoid constituents were determined from Magnolia leaves and flowers. Magnolia leaves constitutively produced two major terpenoids, andamp;acirc;-cubebene and germacrene A. However, upon wounding Magnolia leaves biosynthesized a significant array of monoand sesquiterpenoids, including andamp;acirc;-pinene, trans-andamp;acirc;-ocimene, andamp;aacut

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17

Hecht, Stefan Hermann Karl. "Intermediate und Enzyme des alternativen Terpenbiosyntheseweges." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=964907593.

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18

Chalvin, Camille. "Sclareol biosynthesis in clary sage and its regulation." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS194/document.

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Le sclaréol est un diterpène produit par les organes floraux de la sauge sclarée (Salvia sclarea, Lamiaceae). Il est utilisé en parfumerie pour l’hémisynthèse de l’ambroxide, une substance caractérisée par une odeur ambrée et une grande capacité de fixation des parfums. L’augmentation de la demande mondiale en sclaréol stimule actuellement les tentatives d’accroître le rendement de la production de sclaréol à partir de la sauge sclarée. L’objectif du travail présenté dans ce manuscrit était d’améliorer notre compréhension de la biosynthèse du sclaréol et de sa régulation chez la sauge sclarée,

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19

Lancaster, Jason. "Identification and Functional Characterization of Sesquiterpene Pheromone Biosynthetic Genes in Stink Bugs (Pentatomidae)." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/96290.

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The stink bugs, (Pentatomidae) harlequin bug (Murgantia histrionica), brown marmorated stink bug (Halyomorpha halys), and southern green stink bug (Nezara viridula) are significant agricultural pests both in the United States and globally. The aggregation or sex pheromones produced by these insects are known to be bisabolene-type sesquiterpenoids; however, the biosynthetic pathways in the formation of these pheromones are unknown. Here we provide evidence that Pentatomidae produce sesquiterpene aggregation pheromones de novo and discuss the evolution of terpene biosynthesis in stink bugs. Acco

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20

Arens, Julia [Verfasser], Frank [Akademischer Betreuer] Schulz, and Susanne [Gutachter] Brakmann. "Mikrobielle Biosynthese : Fermentative und chemoenzymatische Synthese zur Erzeugung komplexer Terpene und Polyketidderivate / Julia Arens. Betreuer: Frank Schulz. Gutachter: Susanne Brakmann." Dortmund : Universitätsbibliothek Dortmund, 2015. http://d-nb.info/1110894139/34.

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21

Ouardad, Samira. "Approches bio-inspirées du caoutchouc naturel par polymérisation cationique et modification chimique." Thesis, Bordeaux 1, 2011. http://www.theses.fr/2011BOR14465/document.

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Cette thèse a pour objectif de développer une nouvelle approche bio-inspirée des processus de polymérisation conduisant à la formation de polyterpènes et ultérieurement du caoutchouc naturel, un polyisoprène de structure purement 1,4-cis de forte masse molaire dont les propriétés sont encore inégalées par ses homologues synthétiques. Pour cette raison la production mondiale de caoutchouc naturel demeure stratégique et est toujours proche de 10 millions de tonnes, soit environ 45% de la demande mondiale annuelle en élastomères. Alors que les voies de synthèse développées jusqu’à présent pour ac

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22

Sun, Pulu. "Molecular and biochemical studies of fragrance biosynthesis in rose." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSES005/document.

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La rose est l'une des plantes ornementales les plus populaires, dont les composés volatils sont non seulement impliqués dans les interactions des fleurs avec l’environnement au sens large, mais aussi largement utilisés dans l’industrie des arômes et parfums. Le chapitre 1 décrit l'histoire de la culture de la rose, les usages de son parfum, les connaissances actuelles sur la biosynthèse des composés de ce parfum, ainsi que les voies de biosynthèse des composés volatils qui ont été récemment élucidées chez différentes plantes. Les chapitres expérimentaux 2 et 3 analysent les fonctions de deux g

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23

Mallet, Jean-Maurice. "Reactions d'elimination en serie terpenique : constante de taft de groupes esters phosphoriques : nouvelle reaction de preparation d'ethers et d'esters terbutyliques : inhibiteurs potentiels de la biosynthese des terpenes." Paris 6, 1988. http://www.theses.fr/1988PA066384.

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Etude de 2 reactions enzymatiques impliquees dans la biosynthese des terpenes: l'isomerisation du pyrophosphate d'isopentyle en pyrophosphate de dimethylallyle, par la ipp-dmapp isomerase, et la synthese de pyrophosphate de geranyle et du pyrophosphate de farnesyle, par la prenyltransferase. Modelisation de ces 2 reactions enzymatiques par l'utilisation d'analogues de structure des intermediaires biosynthetiques supposes. Application a la synthese de divers ethers et esters terbutyliques dans des conditions douces

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24

Xu, Ran. "Molecular biological approaches to biomedical problems in sterol and terpene biosynthesis." Thesis, 2003. http://hdl.handle.net/1911/18584.

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Molecular biological techniques represent powerful tools with applications to a wide variety of biomedical problems. Described herein is the use of metabolic engineering to manipulate sterol biosynthesis for medicinal purposes. Also presented is the cloning of terpene biosynthetic genes in plants of agricultural and pharmacological importance. Two examples of metabolic engineering of the Saccharomyces cerevisiae sterol biosynthetic pathway are illustrated in Part I. We first demonstrated the development of genetically engineered S. cerevisiae strains that efficiently produce meiosis activati

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25

Ho, Fang-I., and 何芳儀. "Studies on the Terpene Biosynthetic Pathway of Ganoderma lucidum." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/03007827637406538291.

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26

Meyer, Sven Wolfgang. "Strukturaufklärung der Phenalinolactone und Beiträge zur Biosynthese der Hexacyclinsäure." Doctoral thesis, 2004. http://hdl.handle.net/11858/00-1735-0000-0006-B08C-0.

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27

Serrano, Susana Margarida Guerra. "Genetic determinants of haloarchaeal secondary metabolites, with focus on terpenes." Master's thesis, 2021. http://hdl.handle.net/10773/30827.

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The knowledge on the secondary metabolites (SMs) produced by archaea is a field where few research and experimental testing ha s been done, when comparing to bacteria or fungi.The class Halobacteria, composed by haloarchaea that need high concentrations of salt to survive, has been one of the best well studied in the domain Archae a, in this regard. Some examples include the class model organisms Haloferax mediterranei, Haloferax volcanii and Halobacterium salinarum. Haloarchaea produce halocins that are peptides with anti-archaeal activity, but information regarding their biosynthe

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28

Hart, Elizabeth A. "Metabolic engineering of Saccharomyces cerevisiae towards increased production of terpenes and characterization of sterol biosynthetic enzymes." Thesis, 2001. http://hdl.handle.net/1911/17974.

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The yeast Saccharomyces cerevisiae possesses the endogenous precursor for diterpene production but does not biosynthesize diterpenes. Part I of this thesis describes metabolic engineering of S. cerevisiae to achieve diterpene biosynthesis at 500-fold increased production levels (5 mg/L) relative to levels observed in wild type yeast. Induced expression of S. cerevisiae genes geranylgeranyl pyrophosphate synthase (BTS1) and a truncated form of 3-hydroxy-3-methylglutaryl CoA reductase (HMG1) in yeast carrying the upc2-1 allele afforded accumulating geranylgeranyl pyrophosphate, the universal pr

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