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1
Karp, Stephen A., David E. Silber, Robert W. Holmstrom, and Heather Kellert. "Prediction of MMPI Clinical Scores from the Apperceptive Personality Test." Perceptual and Motor Skills 74, no. 3 (1992): 779–86. http://dx.doi.org/10.2466/pms.1992.74.3.779.
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Eight independent scores from a new objective/projective personality test, the Apperceptive Personality Test (APT), were validated against eight clinical scores of the Minnesota Multiphasic Personality Inventory (MMPI). In parallel studies of 150 male and 150 female college volunteers given both tests, weighted combinations of the 8 APT measures significantly predicted MMPI raw scores in 15 of 16 analyses ( Ma scores could not be predicted for men). Of 84 predicted zero-order correlations between APT and MMPI measures, 50 (60%) were confirmed, 74% for women and 45% for men; however, the vast majority of these correlations were below .30.
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Hidayati, Yunita. "THE EFFECT OF STORYTELLING TOWARDS STUDENTS' SPEAKING SKILL AT X GRADE STUDENTS OF MA NURUL HARAMAIN BOARDING SCHOOL." Journal of Languages and Language Teaching 7, no. 2 (2019): 132. http://dx.doi.org/10.33394/jollt.v7i2.1961.
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This study was aimed to investigate whether or not the use of storytelling has positive effect towards the students' speaking skills at the tenth-grade students of MA Nurul Haramain. The form of this research was pre-experimental study with comparing the scores in pre-test and post-test. The population of this research is the tenth-grade students of MA Nurul Haramain Narmada, with the sample is class X B that consists of 21 students. The research findings show that the mean score of the pre-test is 59.05 and the mean score of post-test is 78.48. It shows that storytelling has a significant impact towards the students' speaking skill. The result of sig. 2-tailed (0.00) is lower than sig. level (0.05), also the result of the t-test is higher than t-table, the value is 4.1 >1.6 it means that the alternative hypothesis (Ha) is accepted. It can be concluded that there is a highly significant effect of storytelling technique towards students' speaking skill on the tenth-grade students of MA Nurul Haramain.
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Sepranalita, Yante, and Yasnur Asri. "KONTRIBUSI KETERAMPILAN MEMBACA PEMAHAMAN TEKS ANEKDOT TERHADAP KETERAMPILAN MENULIS TEKS ANEKDOT SISWA KELAS XI MA NEGERI 3 PADANG." Pendidikan Bahasa Indonesia 8, no. 3 (2020): 489. http://dx.doi.org/10.24036/108238-019883.
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ABSTRACT The purpose of this research is three. First, describing the reading skills of anecdotal text students XI MA Negeri 3 Padang. Secondly, it describes the writing skills of anecdotal text students XI MA Negeri 3 Padang. Third, describing the contribution of reading skills of anecdotal text to the writing skills of anecdotal text students XI MA Negeri 3 Padang. This type of research is quantitative by a descriptive method. The design used in this study is design contributions. The population of this study is the XI MA Negeri 3 class students enrolled in the 2018/2019 school year, with 250 students. The samples in this study were determined by simple random sampling 25% of the population, which is 61 students. This research Data in the form of scores of test skills reads the understanding of anecdotal text and scores test results of anecdotal text. The Data is obtained through two types of tests i.e. objective tests to measure the reading skills of anecdotal text and test performance to measure anecdotal text writing skills. The results of this study were three. First, the reading skills of understanding anecdotal text students XI MA Negeri 3 Padang are in good qualification (B) with an average value of 85.09. Secondly, the writing skills of anecdote-class students XI MA Negeri 3 Padang are on a good qualifying (BS) with an average of 86.13. Thirdly, there is a contribution of the reading skills of anecdotal text to the writing skills of anecdotal text students XI MA Negeri 3 Padang amounted to 17.56%. Kata Kunci:Kontribusi, Keterampilan, Membaca Pemahaman, Menulis, Teks Anekdot
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Caccese, Jaclyn B., and Thomas W. Kaminski. "Comparing Computer-Derived and Human-Observed Scores for the Balance Error Scoring System." Journal of Sport Rehabilitation 25, no. 2 (2016): 133–36. http://dx.doi.org/10.1123/jsr.2014-0281.
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Context:The Balance Error Scoring System (BESS) is the current standard for assessing postural stability in concussed athletes on the sideline. However, research has questioned the objectivity and validity of the BESS, suggesting that while certain subcategories of the BESS have sufficient reliability to be used in evaluation of postural stability, the total score is not reliable, demonstrating limited interrater and intrarater reliability. Recently, a computerized BESS test was developed to automate scoring.Objective:To compare computerderived BESS scores with those taken from 3 trained human scorers.Design:Interrater reliability study.Setting:Athletic training room.Patients:NCAA Division I student athletes (53 male, 58 female; 19 ± 2 y, 168 ± 41 cm, 69 ± 4 kg).Interventions:Subjects were asked to perform the BESS while standing on the Tekscan (Boston, MA) MobileMat® BESS. The MobileMat BESS software displayed an error score at the end of each trial. Simultaneously, errors were recorded by 3 separate examiners. Errors were counted using the standard BESS scoring criteria.Main Outcome Measures:The number of BESS errors was computed for the 6 stances from the software and each of the 3 human scorers. Interclass correlation coefficients (ICCs) were used to compare errors for each stance scored by the MobileMat BESS software with each of 3 raters individually. The ICC values were converted to Fisher Z scores, averaged, and converted back into ICC values.Results:The double-leg, single-leg, and tandem-firm stances resulted in good agreement with human scorers (ICC = .999, .731, and .648). All foam stances resulted in fair agreement.Conclusions:Our results suggest that the MobileMat BESS is suitable for identifying BESS errors involving each of the 6 stances of the BESS protocol. Because the MobileMat BESS scores consistently and reliably, this system can be used with confidence by clinicians as an effective alternative to scoring the BESS.
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Javdan, Najme Sadat, Amir Ghaderi, and Hamid Reza Banafshe. "The Effects of Quetiapine on Craving and Withdrawal Symptoms in Methamphetamine Abuse: A Randomized, Double-Blind, Placebo-Controlled Trial." International Journal of Medical Toxicology and Forensic Medicine 10, no. 4 (2020): 29374.1–29374.7. http://dx.doi.org/10.32598/ijmtfm.v10i4.29374.
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Background: Patients with Methamphetamine Abuse (MA) are susceptible to many complications like craving, and withdrawal symptoms. These trials were designed to evaluate the effect of quetiapine administration on craving and withdrawal symptoms in MA abuse. Methods: This trial was conducted on 60 people with MA abuse to receive either 100 mg quetiapine (n=30), or placebo (n=30) every day for 2 months. The Desire for Drug Questionnaire (DDQ) and Amphetamine Withdrawal Questionnaire (AWQ) scores were evaluated at baseline and after 2 months’ intervention. For data analysis, t test, and the Chi-square test were applied in SPSS v. 18. Results: Quetiapine significantly decreased DDQ (P=0.002) and AWQ symptoms (P=0.001) compared to the placebo. Furthermore, there was a significant difference among groups in terms of the frequency of negative urine tests (P<0.001). Conclusion: This trial showed that administration of quetiapine supplements for 2 months in individuals with MA abuse had beneficial effects on craving and withdrawal syndrome.
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Wang, Kelun, Dennis Boye Larsen, Tanja Kim Jensen, Tiejun Liu, Zhuxuan Liu, and Lars Arendt-Nielsen. "Introducing Vibro-Acupuncture: A Psychophysical Study." Acupuncture in Medicine 34, no. 5 (2016): 373–79. http://dx.doi.org/10.1136/acupmed-2016-011081.
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Background/aim To potentially enhance the effects of conventional acupuncture, a novel acu-vibrator (prototype) has been developed to perform vibro-acupuncture (VA). The aim of this psychophysical study was to investigate the subjective sensations of VA compared with conventional manual acupuncture (MA) and non-penetrating sham acupuncture (SA). Methods 30 young healthy volunteers (21 men and 9 women) received VA, MA, and SA at LI4 and LI10 in a randomised, single-blind, placebo-controlled, cross-over manner. After 25 min of treatment, the Massachusetts General Hospital (MGH) acupuncture sensation scale (MASS), McGill pain questionnaire (MPQ), and numerical rating scale (NRS; 0–10) were employed followed by the acupuncture credibility and indication scale. Adverse events were investigated after treatment. Data were analysed using Friedman's test for repeated measures on ranks and post hoc Wilcoxon signed-rank tests with Bonferroni correction. Results The MASS scores were significantly higher during MA and VA compared with SA at both LI4 and LI10 (p<0.017). Treatment with VA evoked significantly higher vibration sensations compared with MA and SA (p<0.005). Treatment with SA yielded significantly lower NRS and MPQ scores compared with MA and VA (p<0.001) with no difference between MA and VA (p>0.05). Blinding of participants was achieved for SA and MA; however, VA was correctly identified in 29 of 30 subjects due to the characteristic vibrational stimulation. No serious adverse events were recorded for any of the treatments. Conclusions Subjective sensations were influenced by treatment mode, with MA and VA yielding higher stimulation responses compared with SA. VA evoked specific vibrational sensations beyond MA, which might have specific effects in various disorders.
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Hayu Novendiana, Frida, Zakiyah Tasnim, and Bambang Arya Wijaputra. "The Effect of Using Directed Reading Thinking Activity (DRTA) Strategy on the Tenth Grade Students' Reading Comprehension Achievement at MA Unggulan Nuris Jember." Jurnal Edukasi 3, no. 3 (2016): 43. http://dx.doi.org/10.19184/jukasi.v3i3.4309.
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The aim of this research was to know whether or not there was a significant effect of using Directed Reading Thinking Activity (DRTA) strategy on the tenth grade students at MA Unggulan Nuris Jember. The research design used was quasi experimental research specifically post test only non equivalent group design . The respondent of the research was chosen by using cluster random sampling by a lottery . The students of X IPA A as the experimental group and X PK B as the control group. The data was collected by interview, documentation and administering reading comprehension test. Then the data collected were analyzed by using independentt sample T-test . It was known that the mean score of the experimental group was 78.80 and the mean score of the control group was 73.73. In the output of the t-test column, it was shown that the significant value was 0.03. It was lower than 0.05. It means that the mean scores of the two classes (experimental and control groups) were different. Therefore, there was a difference between the experimental class and the control class. In conclusion, the use of Directed Reading Thinking Activity (DRTA) strategy was a significantly affected on the tenthgrade students’ reading comprehension achievement tat MA Unggulan Nuris Jember. 
 
 Keywords: reading comprehension achivement, DRTA strategy
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Faradillah, Nur. "THE EFFECTIVENESS OF MIND READING GAME IN TEACHING." Journal of Languages and Language Teaching 5, no. 2 (2018): 77. http://dx.doi.org/10.33394/jollt.v5i2.362.
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This research was aimed to find out the effectiveness of Mind Reading Game in teaching grammar. This research was experimental design. The population of this study was the second grade students of MA Darul Kamilin which consisted of two classes. One classes were chosen as the samples, those were XI A Class as experimental group consisted of twenty three students and XI B Class as control group consisted twenty three students. They were chosen by using quasi experimental. Experimental group was treated by Mind Reading Game and control group was treated by Mind Game. The instrument that was used objective test in forms of multiple choices. Then, the scores were analyzed by using statistical analysis. It showed the mean score of experimental group was 20,34 while the mean score control group was 16,34 and the value of t (t test) = -4,756 was higher than (t table) = 2,0154 at the significance level of 5% and the number of degree freedom (df) 44. It meant that alternative hypothesis (Ha) was accepted and null hypothesis (Ho) was rejected. It could be conclude that Mind Reading Game was effective in teaching grammar at the second grade students of MA Darul Kamilin
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Ma, Rui, Lynn E. Henrichsen, Troy L. Cox, and Mark W. Tanner. "Pronunciation’s role in English speaking-proficiency ratings." Journal of Second Language Pronunciation 4, no. 1 (2018): 73–102. http://dx.doi.org/10.1075/jslp.00004.ma.
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Abstract Although pronunciation is an integral part of speaking, the role pronunciation plays in determining speaking-proficiency levels is unclear (Higgs & Clifford, 1982; Kang, 2013). To contribute to our understanding of this area, the research reported here investigated the relationship between English as a Second Language (ESL) learners’ pronunciation ability and their speaking-proficiency ratings. At an intensive English program (IEP) in the United States, a speaking test was administered to 223 ESL students. Their speaking proficiency was rated using an oral proficiency assessment based on standardized guidelines. In addition, their pronunciation was rated in six categories (vowels, consonants, word stress, sentence stress, intonation, and rhythm) by 11 raters using a rubric specifically developed and validated for this study. Many-Facet Rasch Measurement (MFRM) was used to estimate the students’ pronunciation ability, which was then compared to their speaking ability. The study found that sentence stress, rhythm, and intonation accounted for 41% of the variance in the speaking-proficiency test scores with sentence stress being the most powerful factor.
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Giorgetti, Daniela, Emilio López-Navarro, and Enric Munar. "Efecto del entrenamiento en ábaco mental sobre la flexibilidad cognitiva: un estudio exploratorio." Revista de Investigación en Educación 18, no. 3 (2020): 316–23. http://dx.doi.org/10.35869/reined.v18i3.3270.
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Mental Abacus (MA) training teaches students to solve math problems by visualizing a physical abacus structure to perform arithmetic operations. Research shows that MA practice relates with enhanced working memory in children, but other cognitive processes that could mediate the benefits registered remain unknown. The aim of the study was to analyze the effect of MA training in a cognitive flexibility task in twelve-year-old children, and compare it with a control group. 121 children from the sixth course of primary education were recruited. 54 students received MA training added during the academic year, while the control group received normative arithmetic instruction. MA training was provided by UCMAS Mental Arithmetic Spain S.L. To assess cognitive flexibility, we used the Trail Making Test (TMT). Data analysis entailed parametric assumptions check and a one-way ANOVA between MA and control group. There were no differences between groups in age. There were statistical differences in TMT-A (Z=-5,78, p<,001, d=,67) and TMT-B scores (Z=-2,24, p=,021, d=,08). Our data suggest that MA enhances cognitive flexibility in children. MA is a promising tool teaching math which benefits go beyond arithmetic calculation.
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Zhang, Haolin, Jungang Sun, Chao Wang, et al. "Randomised Controlled Trial of Contralateral Manual Acupuncture for the Relief of Chronic Shoulder Pain." Acupuncture in Medicine 34, no. 3 (2016): 164–70. http://dx.doi.org/10.1136/acupmed-2015-010947.
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ObjectiveTo explore the effects of contralateral manual acupuncture (MA) on patients with chronic shoulder pain.MethodsEighty patients with chronic shoulder pain were randomly allocated to receive contralateral MA (n=38) for 4 weeks or to remain on a waiting list while receiving conventional orthopaedic therapy (n=42). Visual analogue scale (VAS) scores were taken as the primary outcome measure and used for a priori power calculation. Secondary outcome measures for the assessment of shoulder mobility and quality of life included the Jobe test, the Constant-Murley (CM) score, the Disabilities of the Arm, Shoulder and Hand (DASH) score, and the 36 item Short Form Health Survey (SF-36).ResultsIntention-to-treat (ITT) analysis demonstrated significant pain relief with contralateral acupuncture, with mean differences in VAS scores compared to the waiting list group of −19.4 (−28.0 to −10.8) at 2 weeks, −40.4 (−49.0 to −31.8) at 4 weeks, −41.1 (−49.7 to −32.5) at 8 weeks, and −40.9 (−49.5 to −32.3) at 16 weeks. CM and DASH scores were also improved at all time points (p<0.01). Shoulder mobility, physical functioning, social functioning and mental health components of the SF-36 were also improved by contralateral acupuncture at 8 weeks. No significant adverse effects were observed.ConclusionsThese results demonstrate beneficial effects of contralateral acupuncture in the treatment of chronic shoulder pain, both in terms of pain and function. Future research is required to compare directly the effects of local and contralateral acupuncture and to quantify the specific and non-specific effects.Trial Registration NumberNCT01733914.
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Shiao, Yi-Hsien, Yi-Chih Chen, Yuan-Chieh Yeh, and Tse-Hung Huang. "Positive Effects of Laser Acupuncture in Methamphetamine Users Undergoing Group Cognitive Behavioral Therapy: A Pilot Study." Evidence-Based Complementary and Alternative Medicine 2021 (May 22, 2021): 1–8. http://dx.doi.org/10.1155/2021/5514873.
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Background. Methamphetamine (MA) addiction has become a crucial public health concern because of its adverse consequences to individuals and the society. Objective. To investigate the clinical efficacy of laser acupuncture combined with group cognitive behavioral therapy for MA addiction treatment. Materials and Methods. MA users who participated in group cognitive behavioral therapy and met the inclusion criteria were referred from psychiatrists to participate. The participants received laser acupuncture treatment once a week for 2 months (total eight treatments) on selected acupoints (PC6, HT7, LI4, ST36, SP6, and LR3). Laboratory assessment included urinalysis for MA and liver function tests aspartate aminotransferase, alanine aminotransferase, and γ-glutamyltransferase (AST, ALT, and γ-GT), whereas the objective assessment included visual analog scale (VAS) for MA craving and refusal and Pittsburgh sleep quality index (PSQI), Beck Anxiety Inventory (BAI), and Beck Depression Inventory (BDI) questionnaires. All data were collected before and at 1 and 2 months after treatment. Cognitive behavioral therapy completion rate and rate of relapse to MA use were also determined. Result. Fifteen participants were enrolled, of whom seven completed the trial. Urinalysis for MA revealed a decrease in drug use from 57.1% to 28.6%. Compared with those before treatment, PSQI scores were significantly lower at 1 and 2 months after treatment (−3.73 and −4.10, respectively; both p < 0.001 ), and so were BDI scores (−5.64 and −8.17, respectively; p = 0.01 and 0.001, respectively). However, no significant difference was observed in the liver function test, VAS of craving and refusal, and BAI results. A slight improvement in the motivation for drug abstinence and anxiety was observed during the treatment course. Participants reported no adverse events. Conclusion. Laser acupuncture combined with group cognitive behavioral therapy may improve sleep quality, alleviate depression, and reduce MA use. Additional large-scale studies confirming the effectiveness of this modality are warranted.
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Hafida, Siti Hadiyati Nur, Mohd Hairy Ibrahim, Siti Azizah Susilawati, Rahmat Riandi Suparno, Suharjo Suharjo, and Wahyu Widiyatmoko. "The Effectiveness of Jigsaw Strategy in Geography Subject of Earth as Living Space Material." Indonesian Journal on Learning and Advanced Education (IJOLAE) 2, no. 1 (2019): 47–55. http://dx.doi.org/10.23917/ijolae.v2i1.9273.
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The purpose of this study is to improve student learning in geography subjects at class X of MA Muhammadiyah Gantung Belitung Timur in academic year 2018/2019 using the Jigsaw strategy. The subject of the study was class X, amounting to 22 students. This research is a quasi-experimental research with pretest-posttest design. This study uses a control and experimental group. The conclusion of this research is the implementation of Jigsaw strategy can improve the effectiveness of students in learning geography in class X of MA Muhammadiyah Gantung Belitung Timur. This is consistent with the results of the N-Gain Test in the experimental group which has an average of 31.97 and the control group has an average of 12.52 therefore, the experimental group has a medium value and the control group shows a low value. N-Gain test data showed that the experimental group learning was more effective than the control group. Learning outcomes between the experimental group and the control group showed a difference, the control group had an average pre-test value of 60 and an average post-test of 65. The experimental group had an average score of 61.82 and the post-test -test 74.09. The experimental group had higher pre-test and post-test scores compared to the control group, therefore Ha was accepted while Ho was rejected, this shows that the use of jigsaw learning strategies in the experimental group was effective in increasing students' knowledge and understanding of earth material as the space of life.
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Millar, Susanna, and Miriam Ittyerah. "Movement Imagery in Young and Congenitally Blind Children: Mental Practice without Visuo-spatial Information." International Journal of Behavioral Development 15, no. 1 (1992): 125–46. http://dx.doi.org/10.1177/016502549201500107.
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The study explored whether young children and congenitally totally blind children show mental practice effects for blind movements which cross the body midline. Experiment 1 tested blindfolded sighted children, with a mean age of 7 years and 11 months, on recall of a linear movement. Prior to recall, subjects either had to perform, or to imagine irrelevant (larger/smaller/same) movements. Irrelevant movements produced significant bias (CE/Constant Errors), whether carried out or imaged, although bias from imagined movements was smaller. The VE (variance/consistency) scores improved with (actual and mental) rehearsal. Articulatory suppression during delays had no effect. Experiment 2 used the same paradigm to test three groups of congenitally totally blind children with respective mean Mental Ages (MA) of 10 years and 7 months, 13 years and 7 months, and 16 years and 4 months, based on IO scores on the Williams Intelligence Test (1956) for visually handicapped children. Irrelevant movements during delays produced bias (CE) in recall, whether the movements were carried out or imagined, although bias was smaller in imagery conditions. The (CE) bias effects did not interact with MA. Mental Age interacted significantly with Delay Tasks in VE scores. The lowest MA group was less efficient (more variable) than the others, particularly in (actual and imagined) rehearsal. Articulatory suppression had no effect. The results suggest that young children can show mental practice effects in the absence of current visual cues, and that visuospatial imagery is not a necessary condition, because imagined movements also biased recall by the congenitally totally blind. It was argued that movement as well as cognitive factors can be involved in mental practice effects, and that the nature of mediation depends on the available information.
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Vovk, К., O. Sokruto, A. Кratenko, R. Redkin, N. Orlovetska, and O. Dankevych. "The study of medication adherence in patients with arterial hypertension in the practice of a family doctor." News of Pharmacy, no. 1(101) (February 1, 2021): 76–82. http://dx.doi.org/10.24959/nphj.21.43.
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The treatment of arterial hypertension (AH) is one of the most significant problems of modern internal medicine. Elevated blood pressure (BP) is a major risk factor for atherosclerosis, mainly coronary heart disease and damage tothe brain vessels. Medication adherence (MA) is a complex problem in patients with chronic cardiovascular diseases, especially AH.Aim. To study MA when treating patients with AH in a real Ukrainian out-patient practice for 8 weeks.Materials and methods. The sample of 274 patients with AH included men and women over 18 years old with the initial level of office systolic blood pressure (SBP) of 140-179 mm Hg and diastolic blood pressure (DBP) of 99-100 mm Hg against the background of the antihypertensive therapy or without it. Initially, BP was measured at the doctor’s office (office blood pressure) in all patients who were enrolled in the study; the body mass index (BMI), as well as risk factors were calculated, and the concomitant therapy was assessed. The quality of life was determined by a visual analog scale (VAS score). Patient adherence to the drug therapy was evaluated using the Morisky Medication Adherence Scale (MMAS).Results and discussion. To conduct the study according the MMAS test all patients were distributed in two groups with low MA (MMAS = 3 or 4, n = 181) or high MA (MMAS ≤ 2, n = 93) by the psychometric scale. The results of the MMAS test obtained were confirmed by the reliability parameter used in psychometrics (Cronbach’s Alpha ˃ 0.7). It was found at the end of the study that BP levels less than 140/90 mm Hg of 50.6 % of the Low MA group patients and 47.7 % of the High MA group patients were reached. A decrease in SBP < 140 mm Hg or a decrease in 20 mm Hg and more from the initial level, as well as a decrease in DBP < 90 mm Hg or 10 mm Hg and more was observed in 98.8% of patients in the Low MA group and in 98.4 % in the High MA group. After 8 weeks of observation, the quality of life significantly improved in both groups; however, in the Low MA group this improvement was more pronounced – more than 85 points instead of 82.8 by the VAS scores for the High MA group.Conclusions. The effectiveness of the AH treatment and achievement in the target BP level depend on the patient’s MA. Regular visits to the family doctor’s clinic mobilize patients, and are one of the factors that increase adherence to the treatment, along with pharmaceutical care.
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Moy, B., D. Tu, L. E. Shepherd, et al. "NCIC CTG MA.17: Tolerability of letrozole among ethnic minority women." Journal of Clinical Oncology 24, no. 18_suppl (2006): 6018. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.6018.
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6018 Background: Disease free survival was significantly improved in women receiving letrozole after standard adjuvant tamoxifen in the MA.17 trial. Based on the results of MA.17 and of other trials of aromatase inhibitors in early stage breast cancer, chronic aromatase inhibitor therapy, in postmenopausal women free of breast cancer recurrence, is now being widely employed. We analyzed the toxicity of letrozole according to ethnic status among women enrolled in MA.17. Methods: The chi-square test was used for comparison of rates of side effects between the two groups, Caucasian vs. ethnic minority (defined as all non-Caucasians). In a subset of women, quality of life (QOL) was assessed by the SF-36 Health Survey. Mean change scores in QOL from baseline were compared between groups for summary measures and domains using the Wilcoxon test. Results: 352 minority women and 4,708 Caucasians were enrolled in MA.17, of which 183 minority women and 2,339 Caucasians were randomized to receive letrozole. Caucasians were older than minority women and had a slightly longer duration of treatment with prior tamoxifen. Tumor size and nodal status were not significantly different between the two groups. In women who received letrozole, minority women had significantly lower incidence of hot flashes (49% vs. 58%; p = 0.02), fatigue (29% vs. 39%; p = 0.005), and arthritis (2% vs. 7%; p = 0.006) compared with Caucasians. Mean QOL change scores of SF-36 domains for women who received letrozole were not different but minority women had better mental health at 6 month assessment (p = 0.02) and worse bodily pain at 12 month assessment (p = 0.046). Conclusions: Minority women tolerated letrozole considerably better than Caucasians in the MA.17 trial. These preliminary findings suggest that minority women respond differently to letrozole in terms of toxicity. Recent demonstration of genotypic variations in the aromatase gene in different ethnic groups plus likely pharmacogenomic differences suggests that further research is needed to clarify the clinical outcomes of aromatase inhibition in women of diverse ethnicities. Future research strategies should focus on examining in vivo genotype-phenotype correlations to determine the effects of genetic variation on response to anticancer therapy and on toxicities and end-organ effects. [Table: see text]
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Merrouni, Maryam Alami, Abdelkrim Janati Idrissi, Abdelazizi Lamkaddem, Filankembo Kava A.C., Samir El Fakir, and Zouhayr Souirti. "Moroccan Arabic version of the Quality of Life Inventory in Epilepsy (QOLIE-31): translation, cultural adaptation and psychometric validation." Eastern Mediterranean Health Journal 27, no. 3 (2021): 293–99. http://dx.doi.org/10.26719/2021.27.3.293.
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Background: There is currently a growing concern to conduct health-related quality of life (HRQOL) studies among people with epilepsy in low- and middle-income countries, as most data have been derived from high-income countries in North America and Europe. Aims: To translate, adapt and validate the Moroccan Arabic version of the QOL Inventory in Epilepsy-31 (MA-QOLIE-31) to evaluate HRQOL predictors in the Moroccan population with epilepsy. Methods: Adaptation and validation of QOLIE-31 were performed in July 2018 among 118 patients with epilepsy in the Fez–Meknes region. The test was translated, adapted and validated into Arabic according to the Streiner & Norman recommendations. Acceptability, reliability, central tendency and validity of the QOLIE-31 were assessed. Results: The acceptability and reproducibility were satisfactory and the internal consistency was strong (Cronbach α = 0.993). The mean (standard deviation) global score of QOL in the MA-QOLIE-31 was 68 (22.16). The scores in the subscales were 51 (36.88) for seizures worry, 48.86 (25.44) for overall QOL, 45.60 (26.73) for well-being, 41.28 (25.37) for energy and fatigue, 47.55 (28.33) for cognitive function, 66.83 (39.49) for medication effects and 52.44 (30.26) for social functioning. Conclusions: The global score of QOL in Moroccan patients with epilepsy is similar to that in patients in low and middle-income countries. MA-QOLIE-31 will facilitate further studies in HRQOL in Morocco and Arabic-speaking countries.
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Schmidt, N. S., A. Voss, S. A. Just, and H. M. Lindegaard. "SAT0233 CHARACTERISTICS OF PRIMARY SJÖGREN’S SYNDROME INCLUDING ULTRASOUND FINDINGS OF THE SALIVARY GLANDS, ESSDAI AND ESSPRI." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1059.2–1059. http://dx.doi.org/10.1136/annrheumdis-2020-eular.4411.
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Background:Studies have shown that salivary gland ultrasonography (SGUS) may have a potential value in the diagnosis of Sjogren’s Syndrome (SS).Knowledge of the association between ultrasonography findings, disease activity and damage, serologic markers and patient report outcome is limited.Objectives:To investigate whether the results of SGUS are associated with disease manifestations and damage measured by doctor-reported activity score index (ESSDAI) and serologic markers. Furthermore to investigate the contribution of patient reported outcome measure (ESSPRI) in disease monitoring.Methods:Patients registered at Odense University Hospital with the diagnosis primary SS were included in a Danish cohort. The patients were characterized using the ESSDAI, ESSPRI, serologic markers and SGUS-findings in submandibular and parotid glands. Schirmer’s test and salivary test were performed for measurement of tear and salivary production.SGUS was performed using a linear transducer, Siemens (ACUSON Sequoia Ultrasound System) on the two parotid and two submandibular glands. SGUS images was scored according to the OMERACT SS severity scoring system from 0 to 3, where 2 is moderate and 3 severe(1). A reliability study was performed in advance of the present study.Spearman´s r correlation coefficient was used to assess correlation between scores.Results:The cohort consisted of 48 Caucasian patients diagnosed with primary SS. Details on patient characteristics are shown in table 1.Table 1.Sex, n (%)Women46 (95.8)Age, mean (95%CI)60 (57-62)Smoking, n (%)Smoker1 (2.1)BMI, n (%)< 18.55 (10.4)18.5 – 24.920 (41.7)25.0 – 29.912 (25.0)30.0 – 34.910 (20.8)> 35.01 (2.1)Serologic markers, n (%)SSa positive33 (68.8)SSb positive22 (45.8)ANA positive38 (79.2)Cryoglobulin positive9 (18.8)ESSPRI 0-10, mean (95%CI)Dryness7.3 (6.7-7.9)Fatigue7.1 (6.4-7.7)Pain5.9 (5.1-6.7)SGUS, n (%)Score 06 (12.5)Score 115 (31.3)Score 213 (27.1)Score 314 (29.2)ESSDAI, n (%)ESSDAI < 5 (low-activity)22 (45.8)≤ 5 ESSDAI ≤ 13 (moderate-activity) ESSDAI ≥17 (35.4)14 (high-activity)9 (18.8)The correlation between ESSDAI-scores and SGUS-scores was r = 0.153 (p = 0.299). The correlation between ESSDAI-scores and ESSPRI-scores (dryness, fatique, pain) was r = 0.071 (p = 0.632), r = 0.254 (p = 0.082) and r = -0.002 (p = 0.987). The correlation between SGUS-scores and ESSPRI-scores (dryness, fatique, pain) was r = 0.124 (p = 0.400), r = -0.292 (p = 0.044) and r = -0.459 (p = 0.001).Conclusion:In a Danish cohort of SS most patients had SSa and ANA autoantibodies. SGUS demonstrated high damage (score 2-3) in approximately half of the patients. ESSDAI activity score did not correlate with SGUS damage scores or the ESSPRI. SGUS damage scores correlated with ESSPRI-scores of fatique and pain, but not dryness.Associations between other factors of importance for damage and SGUS scores are to be analyzed. SGUS and the ESSPRI describe different SS-related dimensions and will probably contribute in disease monitoring in the future.References:[1]Jousse-Joulin S, D’Agostino MA, Nicolas C, Naredo E, Ohrndorf S, Backhaus M, et al. Video clip assessment of a salivary gland ultrasound scoring system in Sjogren’s syndrome using consensual definitions: an OMERACT ultrasound working group reliability exercise. Annals of the rheumatic diseases. 2019;78(7):967-73.Disclosure of Interests:None declared
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Marisya, Susanti, and Noni Febriana. "Kontribusi Tingkat Penguasaan Konsep Menulis Terhadap Kemampuan Menulis Karangan Argumentasi Siswa Kelas X MA Negeri X Koto Singkarak Kabupaten Solok." Jurnal Ilmiah Pendidikan Scholastic 3, no. 2 (2019): 1–6. http://dx.doi.org/10.36057/jips.v3i2.354.
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Background of the problem of the research were: 1) writing an argumentation is a difficult thing for the students, 2) less interest of the students in writing argumentation, 3) students lack master and knowledge of good writing concepts. The pupose of this research is to find out how much the contribution of the master of writing concepts to the ability to write essays in class X MA Negeri X Koto Singkarak.
 Population of the correlation research is the students of into students of grade X MA Negeri X Koto Singkarak sub province of Solok year 2016/2017 with the total sample 40 students. Technique of the taking sample used is total sampling. Instruments of the research used are objective test of mastery of the writing concept and performance tests for writing essay arguments. This Research data in the form of score that have been converted into scores.Data analysis techniques by changing scores into grades. Testing requirements analysis (homogenety test normality test and linearity test) and hypothesis testing Pearson Product Moment (PPM).
 The Result of the research concluded that writing concept shows the significant contribution in 29,59% into writing ability of an argumentation. The findings of this research indicate that the hinger the level of master of syudent’ writinh concepts, the hinger the ability to write essays of argumentation. Therefore, The teacher is advised to pay attention to the master of students’ writing concepts and Gide encouragement to students to do writing avtivties so that their argument writing abilities improve.
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Widowati, Sri, Sri Ngabekti, and Nugroho Edi Kartijono. "The Student’s Motivation and Outcome by ARCS (Attention, Relevance, Confidence, Satisfaction) Learning on Ecosystem Concept." Journal of Biology Education 7, no. 3 (2018): 332–39. http://dx.doi.org/10.15294/jbe.v7i3.25823.
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This study aims to determine the learning of class X MA Al Asror students in biology teaching and learning activities with ARCS learning. The sample which is used is class X MIA 1 and it is determined by simple random sampling. The results of the t-test on the scores of students' learning motivation obtained sig. value of 0,000 < 0,05, r value is 0,774, and calculated t value is -16,658 which shows that there is a difference between students’ learning motivation in non-ARCS learning and students’ learning motivation in ARCS learning and there is a relationship between ARCS learning and students' learning motivation with the contribution of 60%. The increase in students’ learning motivation is analyzed by N-gain test with the average N-gain score of 0.39. The classical completeness in non-ARCS learning is 0% while in ARCS learning is 66.67%. The result of multiple correlation of learning motivation and student performance on learning outcomes show r2 of 0.241.
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Sastiawan, Roni, Aceng Ruyani, and Bhakti Karyadi. "Kemampuan Pemecahan Masalah pada Siswa Kelas X MA Suka Negeri Begkulu Selatan Melalui Pembelajaran Berbasis Lingkungan." PENDIPA Journal of Science Education 3, no. 2 (2019): 84–89. http://dx.doi.org/10.33369/pendipa.3.2.84-89.
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ABSTRACT[Capacity statisfaction student class X Madrasah Aliyah Suka Negeri Bengkulu Selatan though learning based on environtment]. The research aims to measure student performance and know the ability to solve problems through environtment – based learning activities on student of class X Madrasah AliyahSukaNegeri South Bengkulu, this study used pre test and post test. Pre test used to determine students’ early ability. Post test is done to determine the ability to solve the problem of leaners by using LKPD problems based learning . Results of student performance in groups obtained from the learning process using LKPD. Data were analyzed descriptively qualitative. Scores obtained from all aspects assessed are converted to determine the group assessment criteria. Ability to solve the problem of class X student Madrasah AliyahSukaNegeri from the aspect of classical performance included into the category of good and evaluation there is an increase in value between pre test and post test.Keywords: Environment based learning; Student performance capability; problem solving skills.(Received November 19, 2018; Accepted April 15, 2019; Published June 18, 2019)ABSTRAKTujuan dari penelitian ini adalah untuk mengukur kinerja siswa kelas X Madrasah Aliyah Suka Negeri Bengkulu Selatan pada materi keanekaragaman hayatidan mengetahui kemampuan siswa kelas X Madrasah Aliyah Suka Negeri Bengkulu Selatan dalam memecahkan masalah melalui kegiatan pembelajaran berbasis lingkungan. Prosedur penelitian menggunakan tes pre test dan post test. Tes pre test digunakan untuk mengetahui kemampuan awalsiswa. Post test dilakukan untuk mengetahui kemampuan memecahkan masalah peserta didik setelah belajar dengan menggunakan Lembar Diskusi Peserta Didik ( LKPD ) problem based learning. Data kinerja siswa secara kelompok yang di dapat dari menjawab Lembar Diskusi Peserta Didik ( LKPD ) dianalisis dengan cara deskriptif kualitatif. Skor yang diperoleh dari seluruh aspek yang dinilai kemudian dikonversikan untuk menentukan kriteria penilaian secara kelompok. Kemampuan memecahkan masalah siswa kelas X Madrasah Aliyah Suka Negeri Bengkulu Selatan dari aspek kinerja secara klasikal termasuk kedalam kategori Baik dan hasil evaluasi terdapat kenaikan nilai antara pre test dan post test.Kata Kunci: Pembelajaran berbasis lingkungan; Kemampuan kinerja siswa; Kemampuan Memecahkan masalah.
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Sastiawan, Roni, Aceng Ruyani, and Bhakti Karyadi. "Kemampuan Pemecahan Masalah pada Siswa Kelas X MA Suka Negeri Begkulu Selatan Melalui Pembelajaran Berbasis Lingkungan." PENDIPA Journal of Science Education 3, no. 2 (2019): 84–89. http://dx.doi.org/10.33369/pendipa.v3i2.7695.
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ABSTRACT[Capacity statisfaction student class X Madrasah Aliyah Suka Negeri Bengkulu Selatan though learning based on environtment]. The research aims to measure student performance and know the ability to solve problems through environtment – based learning activities on student of class X Madrasah AliyahSukaNegeri South Bengkulu, this study used pre test and post test. Pre test used to determine students’ early ability. Post test is done to determine the ability to solve the problem of leaners by using LKPD problems based learning . Results of student performance in groups obtained from the learning process using LKPD. Data were analyzed descriptively qualitative. Scores obtained from all aspects assessed are converted to determine the group assessment criteria. Ability to solve the problem of class X student Madrasah AliyahSukaNegeri from the aspect of classical performance included into the category of good and evaluation there is an increase in value between pre test and post test.Keywords: Environment based learning; Student performance capability; problem solving skills.(Received November 19, 2018; Accepted April 15, 2019; Published June 18, 2019)ABSTRAKTujuan dari penelitian ini adalah untuk mengukur kinerja siswa kelas X Madrasah Aliyah Suka Negeri Bengkulu Selatan pada materi keanekaragaman hayatidan mengetahui kemampuan siswa kelas X Madrasah Aliyah Suka Negeri Bengkulu Selatan dalam memecahkan masalah melalui kegiatan pembelajaran berbasis lingkungan. Prosedur penelitian menggunakan tes pre test dan post test. Tes pre test digunakan untuk mengetahui kemampuan awalsiswa. Post test dilakukan untuk mengetahui kemampuan memecahkan masalah peserta didik setelah belajar dengan menggunakan Lembar Diskusi Peserta Didik ( LKPD ) problem based learning. Data kinerja siswa secara kelompok yang di dapat dari menjawab Lembar Diskusi Peserta Didik ( LKPD ) dianalisis dengan cara deskriptif kualitatif. Skor yang diperoleh dari seluruh aspek yang dinilai kemudian dikonversikan untuk menentukan kriteria penilaian secara kelompok. Kemampuan memecahkan masalah siswa kelas X Madrasah Aliyah Suka Negeri Bengkulu Selatan dari aspek kinerja secara klasikal termasuk kedalam kategori Baik dan hasil evaluasi terdapat kenaikan nilai antara pre test dan post test.Kata Kunci: Pembelajaran berbasis lingkungan; Kemampuan kinerja siswa; Kemampuan Memecahkan masalah.
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Kotarska, Katarzyna, Leonard Nowak, Mirosława Szark-Eckardt, and Maria Nowak. "Selected Healthy Behaviors and Quality of Life in People Who Practice Combat Sports and Martial Arts." International Journal of Environmental Research and Public Health 16, no. 5 (2019): 875. http://dx.doi.org/10.3390/ijerph16050875.
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Background: The quality of life of a society is conditioned by many factors, and depends, among other things, on preferred behavior patterns. Combat sports (CS) and martial arts (MA) have a special educational potential in the area of shaping positive behavior patterns and transmitting moral values which could help reduce aggression in society. The aim of the work was to determine the relationship between health behaviors and the quality of life of people who practice combat sports and martial arts (CS and MA) recreationally, in addition to practicing other sports, and as competitors at the master level. Methods: The research embraced 543 people who practice combat sports and martial arts. Three groups were selected: recreational (n = 362), people who reconciled practicing various sports (n = 115), and competitors who practiced combat sports or martial arts at the master level (n = 66). The average age of the respondents was 24.49 ± 7.82. The standardized WHOQOL-BREF questionnaire and another questionnaire for a lifestyle survey were applied. The Kruskal-Wallis test was used to compare several independent samples. In the case of determining statistical significance of differences the Mann-Whitney test was employed, and for the qualitative data analyses the trait frequency and the independence chi-square test were used. The effect size was calculated for each test ( E R 2 , rg, Cramér’s V). The value of p ≤ 0.05 was assumed to be statistically significant. Results: The highest quality of life (in the physical, psychological and environmental domains) was characteristic of the competitors, who practiced only combat sports and martial arts. They also displayed the most health-oriented behaviors. The surprising results were: lower quality of life in the assessment of nondrinkers and nonsmokers, and higher among people who were overweight. Conclusions: We have found positive correlations between practicing CS and MA, health behaviours and higher scores in quality of life self-evaluation, particularly where practitioners are exclusively focused on CS and MA and practice these at a competitive level. Our findings thus support the growing evidence that competitive level CS and MA are an effective means of improving people’s quality of life. Future research needs to clarify whether CS and MA can also be recommended to recreational and non-competitive practitioners as a means to improve their subjective quality of life.
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Ashraf, Hamid, Fatemeh Ahmadi, and Javad Gh Domsky. "Assessing Iranian Student-Teachers’ Problem-Solving Ability: A Comparison between Conventional and Problem-Based Assessment." International Journal of Education and Literacy Studies 5, no. 3 (2017): 41. http://dx.doi.org/10.7575/aiac.ijels.v.5n.3p.41.
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The advent of problem-based assessment has opened the question of whether or not conventional approaches to assessment are truly a representative of students’ knowledge (Lampert, 2001). In an attempt to find out about the suitability of problem-based tests in evaluating student-teachers’ knowledge of teaching English, a problem-based test was designed and administered to 33 MA students who were selected through the quota approach at Payame Noor University. Comparison of the results of the problem-based test and conventional test through paired-samples t-test revealed that teacher-students gained higher scores in the conventional tests; however, the results of the semi-structured interview with the participants revealed that they considered problem-based test a true measure of their knowledge and favored it over conventional assessment due to its relevance to content and context of the course, its motivating nature, and its dynamic structure. This study can have pedagogical implications for language teachers and material developers.
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Jobling, Anne. "Attainment of Motor Proficiency in School-Aged Children with Down Syndrome." Adapted Physical Activity Quarterly 16, no. 4 (1999): 344–61. http://dx.doi.org/10.1123/apaq.16.4.344.
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This longitudinal research examined the development of motor proficiency in 99 children with Down syndrome born in Brisbane from 1973 to 1984. The Bruininks-Oseretsky Test of Motor Proficiency (BOTMP) was used to assess motor proficiency, and the Stanford-Binet L-M was used to obtain a measure of general intelligence. Although significant progress on the BOTMP subtest scores occurred with age for most subtests, this was related to mental age (MA) rather than chronological age (CA). Progress related to CA was associated with upper limb coordination and upper limb speed and dexterity subtests from CA 10 to 12 years, not from 12 to 16 years. There were considerable inter- and intraindividual differences on subtest items. A cluster analysis of 263 assessments revealed no one profile of strengths and weaknesses. Two distinct profiles were found with high scores in either the visual–motor or the running speed and agility subtests, with balance scores at a low level of proficiency in both clusters. Across the study groupings, sex differences were also evident.
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Rahma, Endah Anisa, and Rusma Setiyana. "Sosialisasi Trik Menjawab Soal Reading dalam Ujian Nasional Bahasa Inggris di SMKN 1 Samatiga Aceh Barat." Jurnal Pengabdian Masyarakat: Darma Bakti Teuku Umar 1, no. 1 (2019): 101. http://dx.doi.org/10.35308/baktiku.v1i1.1436.
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Reading is one of the types of questions asked in National Examination. Senior High School/ MA/ SMK students face difficulties in answering reading questions because they require to analize and compare the passage. Based on the results of a study by the Research Center of the Ministry of Education and Culture (2019), only under 50% of students were able to answer the English National Examination questions. Based on these facts, it is necessary to hold a socialization about understanding English test questions and the types of questions asked in the National Examination. In this community service activity, students of SMKN 1 Samatiga who will face the National Examination are the target of the activity. This activity was carried out by lecturing, discussion and simulation test questions. After being given an understanding of the tricks in answering reading questions, the test results showed that students get scores above 50 for each aspect of the question discussed, namely: main ideas, direct and indirect questions, pronoun references, and vocabulary meaning.
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Qanwal, Sumaira, and Mamuna Ghani. "Relationship Between Introversion/Extroversion Personality Trait and Proficiency in ESL Writing Skills." International Journal of English Linguistics 9, no. 4 (2019): 107. http://dx.doi.org/10.5539/ijel.v9n4p107.
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The study aims at investigating the role of extroversion/introversion personality traits in learning writing skills of English as a second language. The selected sample for the research consisted of 57 participants who undertook instruction on &lsquo;Essay Writing and Presentation&rsquo; for six months as a formal course of study in their MA English Program. The research tools consisted of a questionnaire and an achievement test on writing skills. The questionnaire consisted of 30 items all adopted from Eysenck&rsquo;s Personality Questionnaire to measure the introversion/extroversion traits of students&rsquo; personality. After identifying their personality trait (i.e., introvert, extrovert and neurotic), the participants were given an achievement test on writing skills. The participants&rsquo; scores in the achievement test were submitted to SPSS and independent sample t-test was applied. The findings reveal that a significant difference exists between the writing achievement of introvert and extrovert learner groups. However, no difference is found between the writing performance of neurotic and introvert learner groups or between neurotic and extrovert learner groups. The results also reveal that introverts are better learners of ESL writing skills as compared to the extroverts.
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Rai, Nayanjot, and Tamanna Tiwari. "Oral Health Behavior Change in Mexican-American Caregivers: A Community-Based Intervention Study." International Journal of Environmental Research and Public Health 16, no. 18 (2019): 3409. http://dx.doi.org/10.3390/ijerph16183409.
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An oral health prevention intervention was conducted with Mexican-American (MA) caregivers, focused on improving their oral health knowledge, behavior, and self-efficacy. Five in-person intervention sessions were conducted with caregivers, followed by a 15 min skill-building exercise. A goal-setting sheet was provided, and two goals were chosen for fulfilment during the three month intervention period. The data on parental oral health knowledge, behavior, and self-efficacy were collected pre- and post-intervention using a portion of Basic Factors Research Questionnaire (BRFQ). Paired t-tests were conducted to test significant differences in the means of pre- and post-intervention oral health behavior, knowledge, and self-efficacy scores, and pre- and post-intervention individual item scores. Forty six primary caregivers were enrolled. There were significant differences in the means of pre- and post-intervention oral health knowledge (p = 0.003), oral health behavior (p = 0.0005), and self-efficacy scores (p = 0.001). The individual item mean scores showed that there was a significant increase in the number of times caregivers checked for spots (p = 0.016) and a significant decrease in the consumption of sweet or sugary drinks (p = 0.032) post-intervention. Most of the caregivers believed that cavities were caused by germs in the mouth (p = 0.001), sharing utensils with children was bad for their teeth (p < 0.001), and fluoride toothpaste was best for a child’s teeth (p < 0.001). The intervention resulted in improved caregiver oral health knowledge, behavior, and self-efficacy.
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McEwen, Marylyn Morris, Alice Pasvogel, and Carolyn Murdaugh. "Effects of a Family-Based Diabetes Intervention on Family Social Capital Outcomes for Mexican American Adults." Diabetes Educator 45, no. 3 (2019): 272–86. http://dx.doi.org/10.1177/0145721719837899.
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Purpose The purpose of the study is to test the effects of a culturally tailored family-based self-management education and social support intervention on family social capital with Mexican American (MA) adults with type 2 diabetes (T2DM) and their family member. Methods Using a 2-group, experimental repeated-measures design, 157 dyads were randomly assigned to an intervention (group education and social support, home visits, and telephone calls) or a wait list control group. Data were collected at baseline, immediately postintervention (3 months), and 6 months postintervention. A series of 2 × 3 repeated-measures analyses of variance with interaction contrasts were used to test the hypotheses regarding the differential effects on family social capital. Results Social capital outcomes included social integration, social support, and family efficacy. Social integration scores, high for family members and friends and low for community engagement, did not change over time for participants or family members. Participants perceived high support from family for physical activity with an immediate increase postintervention and moderate sabotage for healthy eating with no change over time. A sustained intervention effect was noted for family efficacy for general health and total family efficacy in participants and family members. Conclusions This family-based culturally tailored intervention demonstrated the potential to improve social capital, specifically social support for physical activity and family efficacy for diabetes management for MA adults with T2DM. Ongoing research that examines the family as a critical context in which T2DM self-management occurs and that targets strategies for sustained family social capital outcomes for T2DM is needed.
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Jia, Keqin, Judy Fleiter, Mark King, Mary Sheehan, Wenjun Ma, and Jianzhen Zhang. "Knowledge and behaviors of drunk-driving offenders in Guangzhou, China." International Journal of Alcohol and Drug Research 4, no. 2 (2015): 151–58. http://dx.doi.org/10.7895/ijadr.v4i2.203.
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Jia, K., Fleiter, J., King, M., Sheehan, M., Ma, W., & Zhang, J. (2015). Knowledge and behaviors of drunk-driving offenders in Guangzhou, China. The International Journal Of Alcohol And Drug Research, 4(2), 151-158. doi:http://dx.doi.org/10.7895/ijadr.v4i2.203Aims: To better understand the knowledge and behaviors of drunk-driving offenders relating to alcohol use and driving in thecontext of recently amended Chinese legislation, and to investigate the involvement of alcohol-use disorders.Design: The study was a cross-sectional survey conducted in 2012.Setting and participants: Data were collected at a local jail and 101 participants were recruited while in detention.Measures: Questionnaire items examined demographic characteristics as well as practices and knowledge relating to alcohol useand driving. The Alcohol Use Disorders Identification Test (AUDIT) was used to assess hazardous drinking levels.Findings: Knowledge about the two legal limits for “drink driving” and for “drunk driving” was low, at 28.3% and 41.4%,respectively. AUDIT scores indicated that a substantial proportion of the offenders had high levels of alcohol-use disorders.Higher AUDIT scores were found among the least experienced drivers, those who lacked knowledge about the legal limits, andrecidivist drunk drivers.Conclusions: Limited awareness of legal alcohol limits might contribute to offending; high AUDIT scores suggest thathazardous drinking levels may also contribute. This study provides important information to assist in refining communityeducation and prevention efforts.
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Jia, Keqin, Judy Fleiter, Mark King, Mary Sheehan, Wenjun Ma, and Jianzhen Zhang. "Knowledge and behaviors of drunk-driving offenders in Guangzhou, China." International Journal of Alcohol and Drug Research 4, no. 2 (2015): 151–58. http://dx.doi.org/10.7895/ijadr.vxiy.203.
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Jia, K., Fleiter, J., King, M., Sheehan, M., Ma, W., & Zhang, J. (2015). Knowledge and behaviors of drunk-driving offenders in Guangzhou, China. The International Journal Of Alcohol And Drug Research, 4(2), 151-158. doi:http://dx.doi.org/10.7895/ijadr.v4i2.203Aims: To better understand the knowledge and behaviors of drunk-driving offenders relating to alcohol use and driving in thecontext of recently amended Chinese legislation, and to investigate the involvement of alcohol-use disorders.Design: The study was a cross-sectional survey conducted in 2012.Setting and participants: Data were collected at a local jail and 101 participants were recruited while in detention.Measures: Questionnaire items examined demographic characteristics as well as practices and knowledge relating to alcohol useand driving. The Alcohol Use Disorders Identification Test (AUDIT) was used to assess hazardous drinking levels.Findings: Knowledge about the two legal limits for “drink driving” and for “drunk driving” was low, at 28.3% and 41.4%,respectively. AUDIT scores indicated that a substantial proportion of the offenders had high levels of alcohol-use disorders.Higher AUDIT scores were found among the least experienced drivers, those who lacked knowledge about the legal limits, andrecidivist drunk drivers.Conclusions: Limited awareness of legal alcohol limits might contribute to offending; high AUDIT scores suggest thathazardous drinking levels may also contribute. This study provides important information to assist in refining communityeducation and prevention efforts.
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Peña, Pilar, Miguel A. Ortega, Julia Buján, and Basilio De la Torre. "Influence of Psychological Distress in Patients with Hypoallergenic Total Knee Arthroplasty. Treatment Algorithm for Patients with Metal Allergy and Knee Osteoarthritis." International Journal of Environmental Research and Public Health 18, no. 11 (2021): 5997. http://dx.doi.org/10.3390/ijerph18115997.
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The outcome in total knee arthroplasty (TKA) depends on multiples factors, among them is the psychological condition. In addition, up 15 to 30% of the patients that undergo TKA show little or no improvement after surgery, which implies the diagnosis of a painful TKA is a challenge for the orthopedic surgeon, who must rule out a possible metal allergy (MA). It is considered an exclusion diagnosis. Due to the complex relationship between psychological condition and MA, and according to the worse results in patients treated with a hypoallergenic TKA, we asked: (1). What degree of psychological distress (PD) is present in patients who have a hypoallergenic TKA, and how does it influence the results of quality of life (QoL) and functional capacity. (2). Can we develop a new algorithm for patients with a possible MA that improves the outcomes? A pragmatic clinical study was carried out that included patients who underwent hypoallergenic TKA during three consecutive years. Quality of life and functional capacity were measured with (Western Ontario McMaster Universities Osteoarthritis Index) WOMAC index, the Short Form 12 questionnaire (SF-12) questionnaire, and the The EQ-5D-5L questionnaire essentially consists of two pages: the EQ-5D descriptive system and the EQ visual analogue scale (EQ VAS) (Euro-QoL-5D L-VAS (EQ5D)), in all patients. To assess PD, a Psychological Distress Score was developed. SPSS software was performed to statistical analysis, and Student´s test for independent variables with a p < 0.005 as statistically significant. A total of 72 anallergic TKAs in 64 patients were treated during this period; 31.3% of these patients showed features of PD before the surgery. According with the severity of the PD, 60% were classified as severe, 10% as moderate and 30% as mild. Patients with PD had statistically significant worse results on the final WOMAC, SF-12, and EQ5D questionnaires. The final scores of the physical subscale of the SF-12 and EQ5D showed better results in patients diagnosed by psychiatrist. Up to one third of the patients with hypoallergenic TKAs have PD, and their results are clearly inferior to those patients with MA without PD. When PD was diagnosed according with Psychological Distress Score, patients should be carefully assessed in order to determine if a specialist referral is recommended. According with our results, PD should be assessed either by the PCP or by us. If the PD is confirmed, a psychiatry referral is then requested for better preoperative management and treatment. We believe that this approach would lead to better TKA outcomes.
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Husaini, Al, Hendra Syarifuddin, and Usmadi Usmadi. "The Practicality of Learning Devices Cooperative Models Based on Blended Learning to Improve Learning Outcomes of 10th-Grade MA Students." International Journal of Trends in Mathematics Education Research 2, no. 3 (2019): 157. http://dx.doi.org/10.33122/ijtmer.v2i3.121.
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Less active and low learning outcomes of students learning by the learning model used by the teacher. Among the variations that can be done is to take advantage of existing technological developments. Therefore, a study was conducted involving the development of learning devices. The research carried out was the development of cooperative learning mathematical learning tools in the form of Blended Learning Based Student Worksheets (LKPD). This study aims to produce a blended learning based learning tool that is practical to improve student learning outcomes. This development research uses the Plomp model which consists of three phases namely the initial investigation phase, the development phase, and the improvement phase. The subjects of this study were 10th-grade religion students of MA KMM Kauman Padangpanjang. Based on the learning outcomes, students are active in learning. The results of the interview show that the devices are easily developed and motivate students in learning and the results of the practicality questionnaire that shows the learning tools developed have met the practical requirements in terms of implementation, ease and time needed. The value of each meeting also increases with an average value of 83 daily test scores. Based on these results it can be concluded that the cooperative mathematics learning model based on blended learning to improve learning outcomes of class X MA students can be used practically.
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Temiz Karadağ, D., O. Cakir, S. Şan, A. Yazici, and A. Cefle. "POS0892 QUANTITATIVE CT INDEXES: PROMISING TOOLS FOR OBJECTIVE ASSESSMENT OF PULMONARY FIBROSIS IN SYSTEMIC SCLEROSIS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 702.1–702. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3992.
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Background:Pulmonary fibrosis (PF) occurs in the majority of patients with SSc and is a leading cause of SSc-related death. SSc related PF has heterogeneous disease progression: many patients will have a chronic, indolent course while others may develop the progressive, life-threatening disease.Objectives:The objective of this study is to investigate the discrimination performance of quantitative CT indexes in identifying the parenchymal differences between the SSc and the control groups. We also aimed to demonstrate the correlation among quantitative indexes (QI), spirometric pulmonary function tests, and visual CT scores in patients with PF.Methods:A total of 135 SSc patients (female 87.4%; age, 50±13 years), 41 of whom had pulmonary fibrosis (PF), and 38 healthy subjects (female 89.5%; age, 52±6 years) were enrolled. All participants underwent volume thin-section CT in the supine position at full inspiration and spirometry. Quantitative indexes (QIs) were obtained using dedicated software for the segmentation of the lung (Vital Images Vitrea Workstation; Version 7.12.3.133). QIs included total lung volume (TLV), low attenuation (LA) volume (-1020 HU<pixel<-920 Hounsfield units [HU]), medium attenuation (MA) volume (-920 HU<pixel<-920 HU), and high attenuation (HA) volume (-720<pixel<0 HU). The global extent of pulmonary parenchymal abnormality was measured semiquantitatively by visual scoring (VS) and functional lung volume was derived. The functional lung volume, total MA volume, and ratio of total MA to total lung volume were assumed as the indexes of normal lung parenchyma.Results:MA volumes, HA volumes, total lung volumes and the ratio of MA volume to total lung volume differed significantly between the patients with PF, patients without PF, and the control group. In the PF group, FVC showed significant correlation with functional lung volume (r=0.45, p=0.014) and total MA volume (r=0.48, p=0.009); DLCO showed significant correlation with VS of normal lung parenchyma (r=0.65, p<0.001), functional lung volume (r=0.53, p=0.006), total MA volume (r=0.54, p=0.005) and ratio of total MA to total lung volume (r=0.42, p=0.031). The functioning lung volume obtained by VS and total MA volume showed excellent correlation (r=0.78, p<0.001).Conclusion:Quantitative indexes measured by soft-ware differentiated the patients with PF from the patients without PF and healthy subjects. The indexes used to evaluate the normal lung parenchyma showed a good correlation with pulmonary function test results. Quantitative indexes can be used as an objective complementary tool for the evaluation of the lung areas unaffected by PF.Table 1.Quantitative Indexes of CT in the Control, SSc without PF and SSc with PF GroupsControlSSc without PFSSc with PFpRight lung LA volume (ml)372±375420±446254±3080.102Right lung MA volume (ml)1230±4081377±441987±451<0.001Right lung HA volume (ml)531±152494±177625±2150.004Left lung LA volume (ml)342±370367±383221±2710.089Left lung MA volume (ml)1014±3831170±433805±402<0.001Left lung HA volume (ml)563±176516±251620±2890.037Total lung LA volume (ml)712±736827±959517±6530.119Total lung MA volume (ml)2212±8632548±8621756±850<0.001Total lung HA volume (ml)1072±3431009±4061290±5220.005Total lung volume (ml)3996±12374385±12563563±12360.002Mean lung density (HU)-799±61.4-798±63-730±75<0.001Total MA volume/Total lung volume0.55±0.120.59±0.130.49±0.150.002Figure 1.Segmentation of lung parenchymaDisclosure of Interests:None declared
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Bibars, Abdel Rahim M., Firas S. D. Alfwaress, Abed Al-Hadi Hamasha, Zeid A. Al-Hourani, and Khader Almhdawi. "Prosthodontic Rehabilitation of Arabic Speaking Individuals with Velopharyngeal Incompetence: A Preliminary Study." Open Dentistry Journal 11, no. 1 (2017): 436–46. http://dx.doi.org/10.2174/1874210601711010436.
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Background:Hypernasality is a frequently encountered problem in the speech of individuals with velopharyngeal incompetence. The use of palatal lift appliance (PLA) is the main treatment option for correction of velopharyngeal incompetence. The literature on the outcomes of using prosthetics treatment for Arabic speaking patients is scarce.Objective:The aim of this study was to investigate the effect of using PLA on hypernasality of Arabic speaking patients with velopharyngeal incompetence.Methods:Six participants with age ranging from 9 to 61 years (4 males and 2 females) were recruited between October 2013 and August 2014. Written informed consents were taken from all the adult participants/the guardians of under-aged participants. All patients exhibited hypernasality with different etiologies for velopharyngeal incompetence (head injury, cerebrovascular accident, and neurological disorders). They were treated with PLAs which were constructed to elevate the dysfunctional soft palate. Nasalance scores and perceptual speech acceptability ratings were measured/evaluated in both situations; with and without appliances. Paired t-test was used to analyze the perceptual ratings and nasalance scores in order to detect any significant change in hypernasality pre and post insertion of PLA.Results:There was a statistically significant decrease (p>0.05) in nasalance scores (Pa, Pi, Ma, Mi, a, i) after PLA insertion. The subtest /u/ showed insignificant change (p= 0.056). Perceptual ratings showed significant reduction in hypernasality which was consistent with nasalance measurements.Conclusion:PLAs can reduce hypernasality in Arabic speaking patients who suffer from velopharyngeal impairment.
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Araghizade, Elmira, and Esmaeil Jadidi. "The Impact of Translators’ Epistemological Beliefs and Gender on Their Translation Quality." English Language Teaching 9, no. 4 (2016): 24. http://dx.doi.org/10.5539/elt.v9n4p24.
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<p>This study aimed to determine the relationship between translators’ epistemological beliefs and gender on their Persian-to- English translation quality. To do so, a group of 53 MA translation students both male and female were selected, through convenient sampling to participate in this study. For data collection two instruments were employed: 1- Epistemic Beliefs Inventory (EBI) 2- Translation Test including a piece of poem. Regression analysis was also conducted to explore the interaction of epistemological beliefs and gender of translators on their translation quality. The findings indicated that there is no significant relationship between the components of epistemological beliefs and translation quality, except in one case that QL (quick learning) has a negative relationship with translation scores. Translators’ gender significantly affects the translation quality. An implication of the results is that males translate significantly better than females regarding the quality of translation. The interaction of translators’ epistemological beliefs and gender significantly affect the translation quality.</p>
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Glass, Benjamin, Michel Erminio Vandenberghe, Surya Teja Chavali, et al. "Machine learning models to quantify HER2 for real-time tissue image analysis in prospective clinical trials." Journal of Clinical Oncology 39, no. 15_suppl (2021): 3061. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.3061.
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3061 Background: Patient eligibility for HER2-targeting treatments is commonly informed by testing tumor HER2 expression using immunohistochemistry. As HER2 expression is visually assessed by pathologists, inter- and intra-rater variability might affect treatment decisions. Here, we report the development of an automated machine learning (ML)-based algorithm to quantify HER2 cell membrane expression across a diversity of breast cancer phenotypes as a clinical tool for monitoring HER2 testing quality. Methods: A total of 689 breast cancer tissue samples were either procured (Avaden Biosciences) or were anonymized samples from the AstraZeneca biobank comprising tissues from primary and metastatic tumors, core needle biopsies and surgical resections, lobular and ductal carcinomas, across tumor grades and HER2 expression levels. Samples were stained for HER2 detection (Ventana HER2 (4B5) Assay) and digitized (Leica Biosystems) across 5 laboratories in the US. Whole-slide images (WSIs) were stratified into training (n = 407), validation (n = 110), and test sets (n = 172). Multiple convolutional neural network based ML models (PathAI, Boston, MA) were trained using 190,000 manual annotations provided by 30 board-certified pathologists to identify artifacts, invasive tumor, identify individual cancer cells and measure tumor cell membrane HER2 expression as partial or complete, and negative, weak-or-moderate, or intense. Cell-level scores were validated against a consensus of manual cell counts from 5 independent pathologists in 320 representative regions of test set WSIs. HER2 scores were generated by automatically applying rules derived from 2018 ASCO/CAP guidelines and then compared in the test set with consensus scores from 3 independent pathologists. Results: Cell counts provided by the ML model were strongly consistent with cell counts obtained by pathologist consensus in all cell-types except for faintly positive HER2 cells where ML-based quantification identified more cells on average. Automatically generated ML-ASCO/CAP HER2 scores using WSI showed substantial consistency across IHC categories with the consensus of pathologists (ICC 0.88, 95%CI 0.82-0.92) in the test set and improved further when ML models were trained to agree with pathologists by adjusting cut offs (ICC 0.91, 95%CI 0.89-0.94). The ML-based model was deployed through the PathAI cloud platform to calculate HER2 testing quality control metrics in real-time in multicentric clinical trials. Conclusions: Automated image analysis of HER2-stained breast cancer tissues using ML-based models is consistent with pathologist consensus across breast cancer tissue types. The results support evidence that ML-based algorithms can help pathologists assess HER2 testing reproducibility in clinical trials.
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Hariyanto, Edy. "Upaya Meningkatkan Aktivitas dan Hasil Belajar Fisika dengan Menerapkan Pembelajaran Kooperatif Tipe Student Team Achievement Division (STAD) dengan Pendekatan Kontekstual." Proceedings of the ICECRS 2, no. 1 (2019): 313. http://dx.doi.org/10.21070/picecrs.v2i1.2397.
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This research is a Classroom Action Research about the application of STAD cooperative learning (Student Teams Achievement Divisions) with a contextual approach to increase student activity and learning outcomes. The research was conducted in 3 cycles of action. each cycle consisting of one meeting for 3 learning hours. The research subjects were students of class X MIPA-1 odd semester of the 2016-2017 academic year MA Ihyaul Ulum Dukun Gresik. Student learning activities are measured based on an increase in the average percentage of student learning activities, while student learning outcomes are based on the difference in scores between the pretest and post in each cycle. Based on the results of the study, it is known that the application of STAD cooperative learning with a contextual approach can increase activities and learning outcomes. Increased student learning activities are indicated by an increase in the average percentage of student learning activities and the level of success of actions from 55% (less) in the first cycle and in the second cycle increased to 67% (sufficient), and increased again in the third cycle to 75% (good ) While the increase in student learning outcomes based on the average score difference between pre-test and post-test in the first cycle of 28.7 increased to 34.1 in the second cycle and increased again to 34.6 in the third cycle, while the completeness of student learning in the cycle I amounted to 42% then in second cycle it increased to 62%, and increased again to 73% in third cycle.
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Shim, I. H., W. S. Woo, H. J. Seo, et al. "Typical profiles of multiple DWI indivisuals on MMPI-2." European Psychiatry 33, S1 (2016): S627. http://dx.doi.org/10.1016/j.eurpsy.2016.01.2353.
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IntroductionAlcohol intoxication is often involved in the commission of criminal behaviors that are risky and involve personal confrontation. Individuals who reported having three or more drinks before driving exhibited greater impulsivity when under the influence of alcohol than did those who did not report heavy drinking before driving.ObjectivesThe present study utilized the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) to compare the characteristics of individuals with a single driving while intoxicated (DWI) offense with individuals who were multiple DWI offenders and to identify whether there was a typical profile for multiple offenders.MethodsThe charts of patients were examined in terms of demographic characteristics including age, sex, employment, and education; the MMPI scores of the two groups were compared using an independent t-test, and we identified the typical profile of multiple DWI offenders by using hierarchical cluster analysis with Ward's method.ResultsScores on the F and the depression (D) scales of the MMPI-2 were significantly higher among multiple offenders than among first offenders. The multiple offenders-I group obtained relatively high scores on the D and psychopathic deviate (Pd) scales, and the multiple offenders-II group had low scores on both the hypomania (Ma) and social introversion (Si) scales. Thus, some multiple offenders may have poorer emotional adjustment, characterized by tendencies toward psychopathic deviance, mania, and depression, as well as psychopathological characteristics associated with patients with alcohol-use disorders.ConclusionThe present findings suggest that multiple offenders should be considered a high-risk group for alcohol-use disorders and recurrent drunken driving.Disclosure of interestThe authors have not supplied their declaration of competing interest.
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Lemieux, Julie, Paul E. Goss, Wendy R. Parulekar, et al. "Patient-reported outcomes from MA.17R: A randomized trial of extending adjuvant letrozole for 5 years after completing an initial 5 years of aromatase inhibitor therapy alone or preceded by tamoxifen in postmenopausal women with early-stage breast cancer." Journal of Clinical Oncology 34, no. 18_suppl (2016): LBA506. http://dx.doi.org/10.1200/jco.2016.34.18_suppl.lba506.
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LBA506 Background: MA.17R is a Canadian Cancer Trials Group (CCTG) led phase III randomized controlled trial comparing letrozole to placebo after 5 years of aromatase inhibitor (AI) as adjuvant therapy for hormone-receptor positive breast cancer. The primary endpoint was disease-free survival. Quality of life (QOL) was a secondary endpoint. Methods: QOL was measured with the SF-36 (2 summary scores and 8 domains) and menopause-specific QOL (MENQOL) (4 symptom domains) at baseline and every 12 months (mo) up to 60 mo. QOL assessment was mandatory for CCTG centres but optional to centres in other groups. Mean change scores from baseline were calculated at 12 and 36 mo. Between-arm differences were assessed with the Wilcoxon test. Results: 1918 patients were randomized and 1428 patients completed the baseline QOL assessment. Compliance with QOL measures was over 85%. Baseline summary scores for SF-36 physical (PCS, 47.5 for letrozole and 47.9 for placebo) and mental (MCS, 55.5 for letrozole and 54.8 for placebo) were close to population norms (50). No differences were seen between groups in mean change scores for the SF-36 PCS and MCS and the other 8 QOL domains. Patients randomized to letrozole reported worse vasomotor symptoms (12 mo p = 0.02, 36 mo p = 0.03) and worse sexual functioning (12 mo p = 0.01, 36 mo p = 0.01). Further analyses with follow up to 60 months will be presented. Conclusions: No differences were seen in overall QOL measured by the SF 36 summary measures between letrozole and placebo groups. Differences existed for vasomotor symptoms and sexual functioning which were worse in the letrozole group and attributed to improvements in mean scores seen for women randomized to placebo. The data indicate that continuation of AI therapy after 5 years prior treatment is not associated with a deterioration of overall QOL. Treatment related vasomotor and sexual functioning alterations occur with ongoing treatment. Clinical trial information: NCT00754845.
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Alinejhad, Donya, Zahra Bahrololoomi, Alireza Navabazam, and M. Ali Asayesh. "Comparison of Visual Analog Scale Scores in Pain Assessment during Pulpotomy using Different Injection Materials in Children Aged 6 to 8 and 8 to 10 Years." Journal of Contemporary Dental Practice 19, no. 3 (2018): 313–17. http://dx.doi.org/10.5005/jp-journals-10024-2259.
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ABSTRACT Aim Proper anesthesia and pain management during treatment are most important concerns in dentistry for people of all ages, especially children. This study compared the success rate of lidocaine block with articaine buccal infiltration during anesthesia of the primary mandibular second molars in children aged 6 to 8 and 8 to 10 years. Materials and methods The present clinical trial was conducted on 40 children aged 6 to 8 and 8 to 10 years who were referred to the Department of Pediatrics of the Faculty of Dentistry at Shahid Sadoughi University of Medical Sciences in Yazd (Islamic Republic of Iran) and needed to be treated with pulpotomy on both primary mandibular second molars. The patients were randomly divided into two groups. At the first session, a group received articaine buccal infiltration and the other group experienced inferior alveolar nerve (IAN) block. At the next visit, this trend was reversed. Visual analog scale (VAS) was used to evaluate the pain during pulpotomy. Results Data were analyzed by Statistical Package for the Social Sciences (version 17) software using Mann–Whitney test. According to the results of this test, the pain during pulpotomy was significantly lower in the articaine group (p < 0.001). Conclusion Articaine buccal infiltration can be employed for pulpotomy treatment in primary mandibular second molars. Clinical significance This research will eliminate block injection of lidocaine in children and utilize infiltration of articaine for pulpotomy treatment of mandibular teeth, hence preventing lingual nerve damage and prolonging paresthesia of IAN, lip, and cheek bite due to IAN block anesthesia. How to cite this article Alinejhad D, Bahrololoomi Z, Navabazam A, Asayesh MA. Comparison of Visual Analog Scale Scores in Pain Assessment during Pulpotomy using Different Injection Materials in Children Aged 6 to 8 and 8 to 10 Years. J Contemp Dent Pract 2018;19(3):313-317.
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Tucker, David L., Mark Rockett, Mehedi Hasan, Sarah Poplar, and Simon A. Rule. "Does transcutaneous electrical nerve stimulation (TENS) alleviate the pain experienced during bone marrow sampling in addition to standard techniques? A randomised, double-blinded, controlled trial." Journal of Clinical Pathology 68, no. 6 (2015): 479–83. http://dx.doi.org/10.1136/jclinpath-2015-202908.
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AimsBone marrow aspiration and trephine (BMAT) biopsies remain important tests in haematology. However, the procedures can be moderately to severely painful despite standard methods of pain relief. To test the efficacy of transcutaneous electrical nerve stimulation (TENS) in alleviating the pain from BMAT in addition to standard analgesia using a numerical pain rating scale (NRS).Methods70 patients requiring BMAT were randomised (1:1) in a double-blind, placebo-controlled trial. –35 patients received TENS impulses at a strong but comfortable amplitude (intervention group) and 35 patients received TENS impulses just above the sensory threshold (control group) (median pulse amplitude 20 and 7 mA, respectively). Patients and operators were blinded to group allocation. Pain assessments were made using a numerical pain scale completed after the procedure.ResultsNo significant difference in NRS pain recalled after the procedure was detected (median pain score 5.7 (95% CI 4.8 to 6.6) in control vs 5.6 (95% CI 4.8 to 6.4) in the intervention group). However, 100% of patients who had previous experience of BMAT and >94% of participants overall felt they benefited from using TENS and would recommend it to others for this procedure. There were no side effects from the TENS device, and it was well tolerated.ConclusionsTENS is a safe, non-invasive adjunct to analgesia for reducing pain during bone marrow biopsy and provides a subjective benefit to most users; however, no objective difference in pain scores was detected when using TENS in this randomised controlled study.Clinical registration numberNCT02005354.
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Hirano, Y., and J. Hasegawa. "AB0222 COMPARISON OF SELF-INJECTION DEVICES FOR ADMINISTERING ANTI-TUMOR NECROSIS FACTOR AGENTS USING THE ORIGINAL QUESTIONNAIRE IN PATIENTS WITH RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1137.1–1137. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2252.
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Background:Self-injection of biological agents has become a general practice in the treatment of rheumatoid arthritis (RA). Self-injectable biological agents differ in shape, needle thickness, drug fluid volume, and so on. These differences may affect patients’ evaluations of self-injection devices. Five kinds of anti-tumor necrosis factor (TNF) agents can be administered by self-injection in clinical practice in Japan. Information on patients’ evaluations of self-injection devices is important in choosing the agent for the treatment of RA among several agents with the same mechanism of action.Objectives:The aim of this retrospective cross-sectional study was to compare patient evaluations of anti-TNF self-injection devices in the treatment of RA.Methods:RA patients in whom etanercept (ETN) pen 50 mg (Embrel Pen) was switched to ETN biosimilar (BS) 50 mg (ETN-BS [MA]), adalimumab (ADA) syringe 40 mg (Humira syringe) was switched to ADA pen 40 mg (Humira pen), golimumab (GLM) syringe 50 mg (Simponi syringe) was switched to GLM autoinjector (Simponi AI), and certolizumab pegol (CZP) syringe (Cimzia syringe) was switched to CZP autoclicks (Cimzia AC) were asked to answer an originally developed questionnaire (Toyohashi Self-injection Assessment Questionnaire [T-SAQ]; Table 1) before and after switching agents. T-SAQ included 18 questions. A score of 0 indicated “best” and 4 indicated “worst” for each question, with a highest possible score of 72. The patients’ characteristics and T-SAQ scores before and after switching agents were investigated. A statistical analysis of the difference in T-SAQ score between before and after switching was performed using the Wilcoxon signed-rank test. A P value < 0.05 was considered significant.Results:The patients were divided into groups according to the agents they received with switching as follows: switchers from ETN pen to ETN-BS, n = 32; switchers from ADA syringe to ADA pen, n = 28; switchers from GLM syringe to GLM-AI, n = 25; and switchers from CZP syringe to CZP-AC, n = 10. The total T-SAQ scores were as follows, respectively: ETN pen and ETN-BS, 23.5 and 19.0; ADA syringe and ADA pen, 25.8 and 14.9; GLM syringe and GLM-AI, 23.8 and 17.4; and CZP syringe and CZP-AC, 30.6 and 18.8. The total T-SAQ was significantly improved after switching to the pen devices in all the switching groups. In the switchers from ETN pen to ETN-BS, the scores for questions 5, 10, 11, 12, 16, 17, and 18 were significantly improved after switching. The total T-SAQ scores were significantly improved for questions 1, 2, 3, 4, 5, 7, 11, 12, 13, 15, 16, and 17 in the switchers from ADA syringe to ADA pen, for questions 1, 2, 5, 7, 10, 16, and 17 in the switchers from GLM syringe to GLM-AI, and for questions of 1, 2, 3, 4, 5, 7, 11, and 15 in the switchers from CZP syringe to GLM-AC.Conclusion:The pen devices were favorably assessed by the RA patients in whom syringe devices were switched to pen devices for the same agent. The total T-SAQ score improved in the RA patients in whom ETN pen was switched to ETN-BS probably because the thickness of the needle was thinner in the ETN-BS than in the ETN pen. The total T-SAQ score for the ADA pen was lowest probably because the thinnest needle was used (29 gauge) and the amount of drug fluid is smallest (0.4ml). The total T-SAQ score for the CZP syringe was the lowest probably because the thickest needle was used (25 gauge).Disclosure of Interests:None declared
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Sukmawati, Trikadar. "Upaya Meningkatkan Aktivitas Dan Hasil Belajar Kimia Pada Ma-teri Kesetimbangan Kimia Melalui Penerapan Model Pembelajaran Inquiry Based Learning (IBL) siswa kelas XI-IA 5 SMA Negeri 4 Banda Aceh." Jurnal Pendidikan dan Pengabdian Vokasi (JP2V) 1, no. 3 (2020): 307–15. http://dx.doi.org/10.32672/jp2v.v1i3.2295.
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The purpose of this study was to increase the activity and learning outcomes of chemistry on chemical equilibrium. The model used in this study is the Inquiry Based Learning (IBL) learning model. The sub-jects of this study were students of class XI-IA 5 SMA Negeri 4 Banda Aceh with a total of 33 students consisting of 12 male students and 21 female students. This research was conducted in the 2018/2019 Academic Year in a period of 3 months, from September 2018 to November 2018 in the odd semester. This type of research is Classroom Action Research which consists of two cycles and each cycle con-sists of two meetings. Each cycle consists of planning, implementing, observing and reflecting. The data collection technique is to collect test scores that are carried out at the end of each lesson in each cycle using a question instrument (written test). Observation data was carried out by looking at the activeness of students in the learning process. Data were analyzed by means of percentage statistics. The results showed that there was an increase in the completeness of student learning outcomes from 39.33% in the pre-study increased to 66.67% in the first cycle and increased to 81.82% in the second cycle. Student learning activities have increased from sufficient to good categories and good categories have increased to be very good. The application of the Inquiry Based Learning (IBL) learning model can increase the activity and learning outcomes of chemistry in the chemical equilibrium material of class XI-IA 5 SMA Negeri 4 Banda Aceh for the 2018/2019 academic year.
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Jeong, Hyeonseok, Jin Kyoung Oh, Eun Kyoung Choi, et al. "Effects of transcranial direct current stimulation on addictive behavior and brain glucose metabolism in problematic online gamers." Journal of Behavioral Addictions 9, no. 4 (2021): 1011–21. http://dx.doi.org/10.1556/2006.2020.00092.
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AbstractBackground and aimsSome online gamers may encounter difficulties in controlling their gaming behavior. Previous studies have demonstrated beneficial effects of transcranial direct current stimulation (tDCS) on various kinds of addiction. This study investigated the effects of tDCS on addictive behavior and regional cerebral metabolic rate of glucose (rCMRglu) in problematic online gamers.MethodsProblematic online gamers were randomized and received 12 sessions of either active (n = 13) or sham tDCS (n = 13) to the dorsolateral prefrontal cortex over 4 weeks (anode F3/cathode F4, 2 mA for 30 min, 3 sessions per week). Participants underwent brain 18F-fluoro-2-deoxyglucose positron emission tomography scans and completed questionnaires including the Internet Addiction Test (IAT), Brief Self-Control Scale (BSCS), and Behavioral Inhibition System/Behavioral Activation System scales (BIS/BAS) at the baseline and 4-week follow-up.ResultsSignificant decreases in time spent on gaming (P = 0.005), BIS (P = 0.03), BAS-fun seeking (P = 0.04), and BAS-reward responsiveness (P = 0.01), and increases in BSCS (P = 0.03) were found in the active tDCS group, while decreases in IAT were shown in both groups (P < 0.001). Group-by-time interaction effects were not significant for these measures. Increases in BSCS scores were correlated with decreases in IAT scores in the active group (β = −0.85, P < 0.001). rCMRglu in the left putamen, pallidum, and insula was increased in the active group compared to the sham group (P for interaction < 0.001).Discussion and conclusionstDCS may be beneficial for problematic online gaming potentially through changes in self-control, motivation, and striatal/insular metabolism. Further larger studies with longer follow-up period are warranted to confirm our findings.
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Sun, Danyu, Brian T. Hill, Lisa Rybicki, et al. "Efficacy of Standard Dose R-CHOP Alternating with R-HiDAC Followed By ASCT As Initial Therapy of Mantle Cell Lymphoma: Cleveland Clinic Experience." Blood 124, no. 21 (2014): 1730. http://dx.doi.org/10.1182/blood.v124.21.1730.1730.
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Abstract Introduction: A common approach to initial treatment for young, fit patients (pts) with mantle cell lymphoma (MCL) is induction chemoimmunotherapy followed by high dose chemotherapy with autologous stem cell support (ASCT). Induction regimens with modifications of R-CHOP (rituximab-cyclophosphamide-doxorubicin-vincristine-prednisone) and/or incorporation of high dose cytarabine (HiDAC) appear more effective than RCHOP alone, as in R-HyperCVAD/MA (cyclophosphamide-vincristine-doxorubicin-dexamethasone alternating with methotrexate-cytarabine, MDACC), R-CHOP alternating with R-DHAP (rituximab-dexamethasone-cytarabine-cisplatin, European MCL Network) and dose intensified R-CHOP alternating with HiDAC followed by ASCT (Nordic Lymphoma Group). At the Cleveland Clinic, in 2010 we adopted as our standard induction regimen a modification of the Nordic protocol, using standard dose R-CHOP alternating with R-HiDAC for 3 cycles each or, for pts who had already been treated with R-CHOP x 6 cycles prior to referral for ASCT, an additional 2 R-HiDAC. Here we report analysis of our institutional experience with this regimen. We use as historical comparison pts with MCL who underwent ASCT at our institution following R-HyperCVAD/MA or R-CHOP. Method: We retrospectively analyzed the outcome of 87 MCL pts who received first line therapy including ASCT at Cleveland Clinic from Aug 1999 - Apr 2014. Pt characteristics, treatment regimens and biological markers were evaluated with regard to overall survival (OS) and relapse free survival (RFS). Pts were grouped according to induction chemotherapy: Group A (HyperCVAD/MA x4 cycles), Group B (R-CHOP x 6 cycles), and Group C (R-CHOP alternating with R-HiDAC for 6 total cycles or R-CHOP x 6 cycles followed by HiDAC x 2 cycles). All pts received ASCT consolidation therapy with high dose busulfan, cyclophosphamide, and etoposide. OS and RFS were estimated using the Kaplan-Meier method and compared among groups using the log-rank test. Cox proportional hazards analysis was used to identify univariable prognostic factors for OS and RFS. Results: The median age of the entire cohort was 59 years (range: 41-73), with male predominance (74%). All pts had ECOG performance score ≤1, MIPI low/intermediate/high scores were 57%/30%/13%. Complete remission prior to ASCT was achieved in 76% of pts. Pt characteristics, including MIPI scores, were evenly distributed among three treatment groups except for: (1) age (median age at diagnosis Group A=53 yr, Group B=62 yr, and Group C=57 yr, P<0.001) (2) more blastoid subtype in Group A (19%) while Group C had no blastoid subtypes of MCL (0%, P=0.03); and (3) higher proportion of patients in Group C with comorbidities (85.7%, p=0.003). With a median follow-up of 26.6 months, 2 year OS rate (Fig. 1) was 95.2%, 94.7% and 100% in groups A, B and C respectively; 2 year RFS rate (Fig. 2) of 85.7%, 73.7% and 93.3% respectively. In univariate analysis, blastoid subtype (HR=5.37, 95% CI 1.97-14.6), and high risk MIPI score (HR=14, 95% CI 3.38-57.6) were predictive of OS as well as of RFS (HR = 2.76, 95% 1.14-6.69 and HR 6.45, 95% CI 2.41-17.2). Post-ASCT treatment was required for 41% of pts, 8 pts (42.1%) in group A, 38 pts (58.3%) in group B and 5 pts (17.9%) in group C, although pts in group C had shortest follow up to date. In conclusion, our outcomes for pts with newly diagnosed MCL demonstrated no statistically significant difference in OS and RFS among the 3 treatment groups. While longer followup is needed, these data suggest that our less toxic approach of using standard dose and schedule R-CHOP alternating with R-HiDAC, without dose-intense R-CHOP or addition of methotrexate or cisplatin, is highly effective pre-ASCT first line therapy for MCL. Fig 1. Fig 1. Fig. 2 Fig. 2. Disclosures No relevant conflicts of interest to declare.
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Almeida, Solange Maria de, Ana Emília Figueiredo de Oliveira, Rívea Inês Ferreira, and Frab Norberto Bóscolo. "Image quality in digital radiographic systems." Brazilian Dental Journal 14, no. 2 (2003): 136–71. http://dx.doi.org/10.1590/s0103-64402003000200012.
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The aim of the present study was to evaluate the image quality of four direct digital radiographic systems. Radiographs were made of the maxillary central incisor and mandibular left molar regions of a dry skull, and an aluminum step-wedge. The X-ray generator operated at 10 mA, 60 and 70 kVp, and images were acquired with 3, 5, 8, 12, 24 and 48 exposure pulses. Six well-trained observers classified the images by means of scores from 1 to 3. Collected data were submitted to nonparametric statistical analysis using Fisher's exact test. Statistical analysis showed significant differences (p<0.01) in image quality with the four systems. Based on the results, it was possible to conclude that: 1) all of the digital systems presented good performance in producing acceptable images for diagnosis, if the exposures of the step-wedge and the maxillary central incisor region were made at 5 pulses, as well as at 8 pulses for the mandibular left molar region, selecting 60 or 70kVp; 2) higher percentages of acceptable images were obtained with the administration of lower radiation doses in CCD-sensors (charge-coupled device); 3) the Storage Phosphor systems produced acceptable images at a large range of exposure settings, that included low, intermediate and high radiation doses.
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Shivappa, Nitin, Susan E. Steck, Thomas G. Hurley, et al. "A population-based dietary inflammatory index predicts levels of C-reactive protein in the Seasonal Variation of Blood Cholesterol Study (SEASONS)." Public Health Nutrition 17, no. 8 (2013): 1825–33. http://dx.doi.org/10.1017/s1368980013002565.
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AbstractObjectiveTo perform construct validation of the population-based Dietary Inflammatory Index (DII) using dietary data from two different dietary assessments and serum high-sensitivity C-reactive protein (hs-CRP) as the construct validator.DesignUsing data derived from (i) three 24 h dietary recalls (24HR) at baseline and at the end of each subsequent quarter (i.e. up to fifteen over a year) and (ii) a 7 d dietary recall (7DDR) measured at baseline and then quarterly, regression analyses were conducted to test the effect of the DII score on serum hs-CRP as dichotomous (≤3 mg/l, >3 mg/l), while controlling for important potential confounders.SettingExisting data from the Seasonal Variation of Blood Cholesterol Study (SEASONS), a longitudinal observational study of healthy participants recruited in Worcester, MA, USA and participants were followed for 1 year.SubjectsParticipants who had at least one hs-CRP measurement over her/his 1-year participation (n495 for 24HR,n559 for 7DDR).ResultsHigher DII scores were associated with values of hs-CRP >3 mg/l (OR = 1·08; 95 % CI 1·01, 1·16,P= 0·035 for the 24HR; and OR = 1·10; 95 % CI 1·02, 1·19,P= 0·015 for the 7DDR).ConclusionsThe population-based DII was associated with interval changes in hs-CRP using both the 24HR and 7DDR. The success of this first-of-a-kind attempt at relating individuals’ intakes of inflammation-modulating foods using this refined DII, and the finding that there is virtually no drop-off in predictive capability using a structured questionnaire in comparison to the 24HR standard, sets the stage for use of the DII in a wide variety of other epidemiological and clinical studies.
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Blizzard, Daniel J., Michael A. Gallizzi, Christine M. Gagnon, and Steven P. Stanos. "Failed Back Surgery Syndrome and Back Pain Patients: Medications They use and How They relate to Their Emotional and Physical Functioning." Duke Orthopaedic Journal 5, no. 1 (2015): 53–57. http://dx.doi.org/10.5005/jp-journals-10017-1056.
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ABSTRACT Study Design Retrospective analysis. Objective To test the hypothesis that failed back surgery syndrome (FBSS) patients and nonsurgical back pain (NSBP) patients respond differently on psychological measures and differ in pain medication usage. Summary of background data The study was part of an inter disciplinary outpatient functional restoration program. There were 121 participants—42 with FBSS and 79 with NSBP—who participated in a multidisciplinary pain evaluation. Methods A chart review was performed and interventions were not applicable. The outcome measures for the study include: the beck depression inventory (BDI), pain disability index (PDI), statetrait anxiety inventory (STAI), multidimen sional pain inventory pain severity (MPIPS) subscale and medication quantification scale III (MQS-III). Results Pearson's correlation analyses of all patients com bined (28 FBSS and 39 NSBP) revealed significant relationships between MQS-III and BDI (r = 0.388, p < 0.01) and STAI (r = 0.323, p < 0.05). A significant correlation was found between MQS-III and STAI (r = 0.536, p < 0.05) among the NSBP patients. The MQS-III was significantly correlated with BDI (r = 0.536, p < 0.05) and MPI-PS t-scores (r = 0.356, p < 0.05) among the 40 NSBP patients. Independent ttests of mean BDI, PDI, STAI, MPIPS, and MQS-III scores revealed no significant group differences. Conclusion Results suggest that while there is differing cor relation between FBSS and NSBP groups in pain medication use and psychometrics, the mean difference of quantity of pain medications used and scores on psychometric measure ments in these groups are not different. While presurgical psychometrics and pain medication usage were not available for our FBSS patients, our results support that medication quantification with psychological prescreening before surgical intervention for back pain patients may help to limit the number of failed back surgeries. Thus, future research including pre and postsurgical psychological functioning, physical functioning, and pain medication usage is suggested. Gallizzi MA, Gagnon CM, Blizzard DJ, Stanos SP. Failed Back Surgery Syndrome and Back Pain Patients: Medications They use and How They relate to Their Emotional and Physical Functioning. The Duke Orthop J 2015;5(1):53-57.
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Watson, Linda, Siwei Qi, Andrea Deiure, et al. "Predicting symptom complexity: Using autoregressive integrated moving average (ARIMA) models to create responsive clinic scheduling." Journal of Clinical Oncology 39, no. 15_suppl (2021): e13529-e13529. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e13529.
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e13529 Background: Increasing cancer incidence, coupled with a trend in treating patients for longer periods of time, presents challenges in addressing all patients’ symptoms/concerns within the allotted time for ambulatory clinic appointments. Consequently, the ability to forecast and monitor the percentage of cancer patients with different symptom complexity levels is extremely valuable. Symptom complexity is a summary score that weighs the severity of all patient reported symptom scores at one time point. If a clinic could predict how many patients may need more time due to complex symptom management needs, clinic-scheduling templates could be adjusted to include a set number of longer appointments. Methods: Auto Regressive Integrated Moving Average (ARIMA) models were utilized to forecast the percentage of patients with a high symptom complexity level within one cancer clinic in Alberta, Canada. Goodness-of-fit measures such as Bayesian information criterion (BIC) and Ljung-Box test were used to determine optimal form for the ARIMA model. Following model selection, the autocorrelation function (ACF) was performed. These tests together verified that chosen AR, MA and differencing (I) were appropriate. Model performance on the historical data for model fit was summarized by Mean Absolute Error (MAE) and Root Squared Mean Error (RSME). Forecasting accuracy was assessed using mean absolute prediction error by comparing the forecasts with actual clinic data. Results: Of the multiple model structures tested, ARIMA (0, 0, 1) was selected, with the lowest BIC and non-significant Ljung-Box test. We obtained forecasts of the percentage of patients with high symptom complexity levels, with an MAE at 4.0%. To assess forecast accuracy, we calculated the absolute prediction error by comparing the forecasted percentages of patients with high symptom complexity levels to actual clinic visit data and the mean absolute prediction error was 5.9%. Conclusions: This forecasting model has important implications, allowing clinics to adjust scheduling templates to provide a select number of longer timeslots and therefore, be better prepared to meet the symptom management needs of cancer patients who are considered highly complex. This model could be applied to other clinical populations to allow for a tailored scheduling approach based on each clinic’s symptom complexity forecasting.