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Relevant bibliographies by topics / Testicular toxicity / Dissertations / Theses

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Dissertations / Theses on the topic 'Testicular toxicity'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Elkin, Naomi D. "Evaluation of biomarkers for testicular toxicity." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4412.

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Non-clinical safety assessment is essential during the drug development process in the pharmaceutical industry, and involves numerous, detailed in vitro and in vivo toxicology tests (general, reproductive and genetic), and safety pharmacology studies. The testis is a common organ for adverse drug effects leading to attrition of potential compounds. It would, therefore, be useful to detect testicular toxicity as early as possible in the drug development process. Histopathology is the standard method for assessing testis toxicity, but a biomarker for ‘early warning’ detection of testicular toxic

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2

Adegoke, Oluwajoba Oluwapelumi. "Transcriptional and post-transcriptional regulation in testicular toxicity." Thesis, University of Leicester, 2015. http://hdl.handle.net/2381/31979.

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The control of gene expression occurs at multiple levels one of which is controlled by epigenetic regulation. In this work, it was hypothesised that changes in DNA methylation (transcriptional level) and miRNA expression (post-transcriptional level) might be involved in the mechanism of compound-induced testicular toxicity. mRNA and miRNA analysis of mouse testis was performed following exposure to dibutyl phthalate, 17β-estradiol and doxorubicin. Pathway analysis of transcriptional changes revealed all three chemicals interfered with the steroidogenic pathway, with further modulation of oxida

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3

Wahed, I. A. "Testicular toxicity of standard and investigational anti-cancer drugs." Thesis, University of Bradford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.380578.

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4

Piner, J. A. "The novel testicular toxicity of a 5HT-1 receptor agonist." Thesis, University of Edinburgh, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.660620.

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The aims of the work presented in this Thesis were to establish the nature and mechanism of the testicular and epididymal toxicity in Charles River Wistar rats, at least 10 weeks of age, after administration of high dosages of GR403370D, a 5HT-1 receptor agonist that was under development by Glaxo Wellcome for the potential relief of migrainous headaches. Initial investigations used a detailed morphological examination of perfusion-fixed tissues which were confirmed and/or further characterised using image analysis. The testicular vasculature was implicated as the initial target, since a reduc

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5

Rajeh, Nisreen A. "Acrylamide-induced testicular toxicity in rat: modulatory effect of 5-aminosalicylic acid." Thesis, University of Surrey, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.583321.

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Acrylamide (AA) is a vinyl monomer that has many applications in chemical industries. The aim of this work was to assess the reproductive toxicity of AA and clarity its underlying mechanism of action in rat; in particular, whether AA or its reactive metabolite glycidamide is responsible for the majority of the noted adverse effects. Moreover, the protective effect of 5-aminosalicylic acid (5-ASA) against AA testicular and genotoxicity was investigated. Acrylamide gavaged at doses from 5-60mg/kg daily for 5 consecutive days caused dose- dependent toxicity. Light microscopy examination showed mu

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6

Roberts, A. "The metabolism and pharmacokinetics of cyclohexylamine and their relevance to testicular toxicity." Thesis, University of Southampton, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235156.

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7

Martin, Lisa Joy. "FK506, an inhibitor of calcineurin, prevents cadmium-induced testicular toxicity in mice." Diss., Restricted to subscribing institutions, 2007. http://proquest.umi.com/pqdweb?did=1320950781&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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8

Ludwig, Sophie. "Comportement d'un "Perturbateur Endocrinien" et d'un "non Perturbateur Endocrinien" vis à vis de la toxicité testiculaire chez le rat." Phd thesis, Université Paris Sud - Paris XI, 2011. http://tel.archives-ouvertes.fr/tel-00658641.

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Depuis plusieurs années, des agents exogènes environnementaux appelés perturbateurs endocriniens (PE), sont soupçonnés d'interférer avec les fonctions essentielles de reproduction et de développement chez de nombreux organismes vivants. Au travers de ce travail, nous avons tenté de combler certaines lacunes afin de mieux comprendre les dangers pour l'Homme posés par ces produits. Des études ont été menées visant à caractériser la toxicité testiculaire, chez le rat adulte, induite par des composés aux mécanismes d'action toxique divers (PE et non PE), ceci dans le but d'établir in fine l'existe

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9

Lesné, Laurianne. "Antiépileptiques et antalgiques pendant la grossesse et homéostasie du testicule foetal humain." Electronic Thesis or Diss., Université de Rennes (2023-....), 2023. http://www.theses.fr/2023URENB075.

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Le développement fœtal est une période particulièrement vulnérable aux déséquilibres du milieu dans lequel il se déroule. Le testicule fœtal joue un rôle capital dans la masculinisation des organes reproducteurs via sa fonction endocrine, et toute altération peut engendrer un spectre de malformations pouvant impacter la fertilité future de l’homme. Au cours du développement, l’embryon puis le fœtus va être exposé à un l’environnement chimique complexe qu’est l’exposome maternel. Parmi les familles de substances constituant l’exposome se trouvent les médicaments que la femme enceinte consomme p

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10

Azouri, Tannous Hayat. "Étude de la toxicité de deux complexes du platine : description d'un nouveau modèle d'appréciation de la toxicité testiculaire." Paris 11, 1989. http://www.theses.fr/1989PA114822.

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11

Sargeant, Aaron Matthew. "Preclinical Efficacy and Safety Evaluation of Novel Small-Molecule Targeted Agents for the Prevention and Treatment of Prostate Cancer." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1243948876.

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12

Batias, Catherine. "Mise au point et validation d' une méthode d' étude de la toxicité testiculaire chez le rat mâle." Paris 5, 1995. http://www.theses.fr/1995PA05P221.

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13

Ali, Muhammed Wali Sazan. "Effect of environmental factors on spermatogenesis. : Ex-vivo assessment of low level of cadmium or bisphenol A on testicular meiotic cells. : Dosage of metals in semen and in DNA of spermatozoa." Thesis, Aix-Marseille, 2014. http://www.theses.fr/2014AIXM5050.

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Nous avons fait l'analyse des flux cytométrie nous a permis d'évaluer les changements dans le nombre de cellules de Sertoli et germinales par le cadmium. Seulement cellules germinales ont diminué dans le temps et de manière dose-dépendante. CS fragmenté, asynapsis et "mitée" CS ont été observés. Cd induit modifications ex-vivo en cours de la méiose. BPA changé chronologie de la méiose et active le point de contrôle de pachytène. Asynapsis et la fragmentation ont été induites. Noyaux leptotène anormaux, et zygotène asynapsed, observées. CS pulvérisé indiqué les anomalies de recombinaison et / o

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14

Floch-Quintin, Josiane. "La glande uropygienne de la caille : modèle pour l'étude du métabolisme et de la toxicite loco-régionale de stéroïdes hormonaux." Brest, 1988. http://www.theses.fr/1988BRES2024.

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Etude du metabolisme de la testosterone en presence d'homogenats ou sous fractions cellulaires de glandes uropygiennes de caille. La glande uropygienne conduit principalement a la formation de composes 5-beta-reduits et de derives 17-alpha hydroxyles a la difference de ce qui est observe au niveau de la glande sebacee humaine. La formation de ces composes 5-beta reduits et derives 17-alpha hydroxyles depend de l'age de l'animal et du degre de stimulation de la glande. La glande uropygienne est un organe cible de certains anti-androgenes (progesterone-acetate de cyproterone) contrairement a la

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15

Lai, Yu-Hua, and 賴又華. "Investigate the Effects of Honokiol on Cisplatin-Induced Testicular Toxicity." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/35cq5y.

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碩士<br>國立臺灣大學<br>獸醫學研究所<br>106<br>Cisplatin (cis-diamminedichloroplatinum [II]) is a platinum-containing drug widely used for chemotherapy to efficaciously treat various cancers, including ovarian and testicular cancers, and solid tumors of the head and neck. In male, one of its associated side effects is testicular toxicity. The side effects observed in the testis after cisplatin administration are germ cell apoptosis, long–lasting azoospermia, and testicular atrophy. Although the underlying mechanism of cisplatin-induced testicular toxicity is not fully understood, many studies suggested that

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16

MILLER, GEORGE EDWARD JR. "IN VITRO TOXICITY OF 1,2-DIBROMO-3-CHLOROPROPANE TO ISOLATED TESTICULAR CELLS (SPERMATOCYTES, SERTOLI CELLS, LACTATE METABOLISM, MITOCHONDRIA)." 1986. http://books.google.com/books?id=cfg9AAAAMAAJ.

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17

PAVITTRANON, SUMOL. "A STUDY OF THE MECHANISM OF TOXICITY OF 2-METHOXYETHANOL AND 2-METHOXYACETIC ACID ON RAT TESTICULAR CELL CULTURES." 1989. http://books.google.com/books?id=ZeM9AAAAMAAJ.

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18

Kleeman, James Michael. "Toxicology of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in aquatic and mammalian species Part 1. TCDD toxicity, bioaccumulation and biotransformation in fish : Part 2. Effects of TCDD on testicular steriod secretion by the rat /." 1988. http://catalog.hathitrust.org/api/volumes/oclc/18564660.html.

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Thesis (Ph. D.)--University of Wisconsin--Madison, 1988.<br>Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

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