Relevant bibliographies by topics / Testicules – Cancer

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Academic literature on the topic 'Testicules – Cancer'

Author: Grafiati
Published: 4 June 2021
Last updated: 9 February 2022

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Journal articles on the topic "Testicules – Cancer"

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Forrest, Allison, Numbereye Numbere, Jerome Jean-Gilles, Thomas Frye, and Vikram Dogra. "Sonographic Diagnosis of Unilateral Synchronous Testicular Tumors." American Journal of Sonography 2 (April 15, 2019): 2. http://dx.doi.org/10.25259/ajs-3-2019.

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Testicular cancer accounts for 1% of all male cancers yet is the most common cancer affecting men aged 15–44 years. Most testicular cancers are seminomas or non-seminomatous germ cell tumors. Rarely, multiple testicular cancers may occur simultaneously, most often of the same histological type. However, synchronous tumors of different histological types may occur, although rarely. In this case study, we present the sonographic features with histopathologic correlation in a case of unilateral synchronous testicular tumors of discordant histology.
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Vasistha, Aman, Rishi Kothari, Adarsh Mishra, Fernando De Andrés, Adrián LLerena, and Sujit Nair. "Current Insights into Interethnic Variability in Testicular Cancers: Population Pharmacogenetics, Clinical Trials, Genetic Basis of Chemotherapy- Induced Toxicities and Molecular Signal Transduction." Current Topics in Medicinal Chemistry 20, no. 20 (2020): 1824–38. http://dx.doi.org/10.2174/1568026620666200618112205.

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Testicular cancer is an aggressive malignancy with a rising incidence rate across the globe. Testicular germ cell tumors are the most commonly diagnosed cancers, and surgical removal of the testes is often a radical necessity along with chemotherapy and radiotherapy. While seminomas are receptive to radiotherapy as well as chemotherapy, non-seminomatous germ cell tumors respond to chemotherapy only. Due to the singular nature of testicular cancers with associated orchiectomy and mortality, it is important to study the molecular basis and genetic underpinnings of this group of cancers across male populations globally. In this review, we shed light on the population pharmacogenetics of testicular cancer, pediatric and adult tumors, current clinical trials, genetic determinants of chemotherapy-induced toxicity in testicular cancer, as well as the molecular signal transduction pathways operating in this malignancy. Taken together, our discussions will help in enhancing our understanding of genetic factors in testicular carcinogenesis and chemotherapy-induced toxicity, augment our knowledge of this aggressive cancer at the cellular and molecular level, as well as improve precision medicine approaches to combat this disease.
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Li, Jenny, and Nicholas Power. "Scrotal recurrence of germ cell tumour in a non-violated scrotum." Canadian Urological Association Journal 10, no. 11-12 (2016): 388. http://dx.doi.org/10.5489/cuaj.3505.

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Testicular cancer is the most common cancer diagnosis in males aged 15‒30 years. For over a century, radical inguinal orchiectomy has been the standard of care for initial treatment of testicular cancer. This approach is preferred over trans-scrotal interventions, in an effort to avoid tumour seeding, spermatic cord invasion, and disturbance to lymphatic drainage. Scrotal violation is defined as any trans-scrotal intervention that may impact spread of disease in testicular cancer, including scrotal orchiectomy, fine-needle aspiration, and testicular biopsy. Studies have shown statistically significant differences in local recurrence rates between patients who undergo the standard inguinal surgical approach and cases with scrotal violation.Over 95% of testicular cancers are curative, often with surgery alone. Recurrence of disease is divided into two categories: local and distant sites. Local recurrence of testicular cancer involves the scrotal and inguinal regions, including superficial inguinal lymph nodes. More commonly, local recurrence is seen in cases of testicular cancer with scrotal violation. We describe a case of local recurrence of testicular cancer in a non-violated scrotum,
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Dhakal, Radha, Samkisha Paudel, and Dipesh Paudel. "Knowledge, Attitude, and Practice regarding Testicular Cancer and Testicular Self-Examination among Male Students Pursuing Bachelor’s Degree in Bharatpur Metropolitan City, Chitwan, Nepal." BioMed Research International 2021 (August 31, 2021): 1–9. http://dx.doi.org/10.1155/2021/1802031.

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Background. Testicular cancer is a malignant tumor of the testicles, the male reproductive organs that produce sperm and testosterone. It is one of the most common cancers in young men. This form of cancer can be easily diagnosed by self-examination of testicles and is curable if detected early. Periodic self-examination must be performed for early detection. Due to lack of knowledge on testicular cancer and testicular self-examination techniques, patients can potentially miss early detection. This study is aimed at assessing the knowledge, attitude, and practice regarding testicular cancer and testicular self-examination among male college students pursuing a Bachelor’s degree. Methods. A web-based cross-sectional analytical study was adopted to assess the knowledge, attitude, and practice of testicular cancer and testicular self-examination among male college students pursuing a Bachelor’s degree and living in Bharatpur Metropolitan City in the Chitwan District of Nepal. The snowball sampling technique was employed to identify the eligible participants. Collected data were entered in SPSS version 22 and analyzed by using the Chi-square test, Pearson’s correlation, and binary logistic regression. Results. Out of 402 respondents, majority (56.7%) had poor knowledge regarding testicular cancer and testicular self-examination and only 11.4% had performed testicular self-examination. The majority (67.2%) of the respondents had shown an unfavorable attitude towards testicular cancer (TC) and testicular self-examination (TSE). There was a significant association between the level of knowledge and marital status 4.516 (1.962-10.397) and ethnicity 2.606 (1.443-4.709). Likewise, age 0.396 (0.191-0.821) and marital status 0.347 (0.156-0.775) have been significantly associated with testicular self-examination practice. Regarding favorable attitude, age 0.362 (0.186-0.706) and sources of information from mass media 2.346 (1.328-4.143) have been associated significantly. Conclusion. The study finding shows that the knowledge on testicular cancer and testicular self-examination was low. Due to lack of knowledge and trainings, the potential opportunities for early detection of testicular cancer are missed substantially. Periodic testicular self-examination is vital for early detection of testicular cancer. Hence, it is crucial to implement massive educational campaigns and trainings on testicular cancer and testicular self-examination techniques among young male groups.
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Antonaci, Alessio, Daniela Fasanella, Vikiela Galica, et al. "Retroperitoneal extension of massive ulcerated testicular seminoma through the inguinal canal: A case report." Archivio Italiano di Urologia e Andrologia 93, no. 1 (2021): 64–67. http://dx.doi.org/10.4081/aiua.2021.1.64.

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Introduction: Testicular cancers represent about 5% of all urological malignancies and 1-1.5% of all male neoplasms. Most of the testicular cancers are localized (68%) at diagnosis. Bulky masses in the scrotum are rare. We present a rare case of bulky testicular cancer with retroperitoneal spread through the inguinal canal. Case report: A 44-year-old man came to the emergency department referring weakness and the presence of a scrotal mass. At physical examination, a voluminous mass was found, with necrotic phenomena within the scrotum. Abdomen was tense and sore. Abdominal CT scan revealed a bulky testicular mass spreading to the retroperitoneal space through the inguinal canal with node enlargement. Patient underwent orchiectomy with excision of infiltrated scrotum skin. Histologic diagnosis confirmed a typical form seminoma. The patient was then treated with a cisplatin-based chemotherapy, with a partial response. The patient recently relapsed and he is being treated with a new line of chemotherapy and subsequent surgery with or without radiotherapy. Conclusions: We described a rare presentation of testicular cancer. This case highlights the importance of a multidisciplinary approach to rare testis tumour presentation and early diagnosis for testicular cancers.
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Namiq, Kadhim Faruq, Fadhil Ahmed Mohaildeen, and Shalaw Hamaali Abdalla. "A CASE REPORT OF METACHRONOUS METASTATIC TESTICULAR CANCER OF COLORECTAL ORIGIN." Journal of Sulaimani Medical College 8, no. 3 (2018): 217–21. http://dx.doi.org/10.17656/jsmc.10172.

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Curreri, Stephanie A., Sarah C. Markt, Rowan Miller, et al. "Bilateral testicular germ cell tumors." Journal of Clinical Oncology 33, no. 7_suppl (2015): 392. http://dx.doi.org/10.1200/jco.2015.33.7_suppl.392.

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392 Background: Germ cell tumors (GCTs), both seminomatous and non-seminomatous, account for greater than 90% of testicular cancers. While bilateral testicular GCTs are rare, the incidence of bilateral tumors has increased over time. Methods: 668 cases of bilateral and 38,593 cases of unilateral testicular GCTs were reported between 1973 and 2011 by the SEER database. Patient characteristics and tumor features were analyzed. Results: The incidence of bilateral GCTs among men with testicular GCTs was 1.7% (668 of 39,261 total cases). Among the 668 men with bilateral GCTs, 53% (n=353) of second GCTs occurred within three years after the first cancer. 29% (n=196) of bilateral tumors occurred synchronously. Among patients with bilateral GCTs, 378 first GCTs and 466 second GCTs were seminomatous. 43% of bilateral cases were concordant seminomatous GCTs, 16% were concordant non-seminomas, and 41% were discordant histologies. 68% of unilateral GCTs, 70% of first GCTs, and 82% of second GCTs were staged as Localized disease. Testicular cancer was the cause of death for 4% (n=1,630) of men with a unilateral GCT and 1% (n=8) of men with bilateral GCTs. A second malignant neoplasm (SMN) was the cause of death for 2% (n=736) of men with a unilateral GCT and 2% (n=16) of men with bilateral GCTs. Conclusions: Among men with bilateral testicular GCTs, 59% had concordant histological diagnoses between their first and second tumor. Most (53%) second cancers among men with bilateral tumors occurred within three years after diagnosis of first cancers. Men who experience bilateral testicular GCTs do not appear to have an increased risk of death due to testicular cancer or a subsequent non-germ cell malignant neoplasm compared to men with a unilateral testicular GCT. [Table: see text]
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Lempiäinen, Anna, Kristina Hotakainen, Carl Blomqvist, Henrik Alfthan, and Ulf-Håkan Stenman. "Hyperglycosylated Human Chorionic Gonadotropin in Serum of Testicular Cancer Patients." Clinical Chemistry 58, no. 7 (2012): 1123–29. http://dx.doi.org/10.1373/clinchem.2012.183723.

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Abstract BACKGROUND Hyperglycosylated human chorionic gonadotropin (hCG-h) contains larger and more complex carbohydrate chains than regular human chorionic gonadotropin (hCG). hCG-h is thought to be the major form of hCG produced by testicular cancers and it has been suggested to play a key role in tumor invasion, but studies on hCG-h in testicular cancer are limited. We studied whether serum hCG is hyperglycosylated, and whether measurement of hCG-h in serum offers clinical value in the management of testicular cancer. METHODS We determined the serum concentrations of hCG-h, hCG, and the free β subunit of hCG (hCGβ) by time-resolved immunofluorometric assays in 176 serum samples (preoperative n = 67, relapse n = 20, follow-up n = 89) obtained from 84 testicular cancer patients. We analyzed the association between preoperative serum concentrations of hCG, hCG-h, and hCGβ with known prognostic factors and progression-free survival time. RESULTS A major proportion of hCG was hyperglycosylated preoperatively, at relapse, and shortly after treatment. The serum concentrations of hCG-h and hCG correlated strongly with each other and had similar diagnostic value. The preoperative serum concentration of hCG-h correlated with prognostic factors and outcome in the same way as hCG. Increased preoperative hCGβ concentration predicted shorter progression-free survival. CONCLUSIONS Most of the hCG expressed by testicular cancers is hyperglycosylated and therefore it is important that hCG assays used for management of testicular cancer recognize hCG-h.
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Shephard, Elizabeth A., and William T. Hamilton. "Selection of men for investigation of possible testicular cancer in primary care: a large case–control study using electronic patient records." British Journal of General Practice 68, no. 673 (2018): e559-e565. http://dx.doi.org/10.3399/bjgp18x697949.

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BackgroundTesticular cancer incidence has risen over the last two decades and is expected to continue to rise. There are no primary care studies on the clinical features of testicular cancer, with recent National Institute for Health and Care Excellence (NICE) guidance based solely upon clinical consensus.AimTo identify clinical features of testicular cancer and to quantify their risk in primary care patients, with the aim of improving the selection of patients for investigation.Design and settingA matched case–control study in males aged ≥17 years, using Clinical Practice Research Datalink records.MethodPutative clinical features of testicular cancer were identified and analysed using conditional logistic regression. Positive predictive values (PPVs) were calculated for those aged <50 years.ResultsIn all, 1398 cases were available, diagnosed between 2000 and 2012, with 4956 age-, sex-, and practice-matched controls. Nine features were independently associated with testicular cancer, the top three being testicular swelling (odds ratio [OR] 280, 95% confidence interval [CI] = 110 to 690), testicular lump (OR 270, 95% CI = 100 to 740), and scrotal swelling (OR 170, 95% CI = 35 to 800). The highest PPV for 17–49-year-olds was testicular lump, at 2.5% (95% CI = 1.1 to 5.6). Combining testicular lump with testicular swelling or testicular pain produced PPVs of 17% and 10%, respectively.ConclusionTesticular enlargement carries a risk of cancer of 2.5% — close to the current 3% threshold in UK referral guidance. Contrary to traditional teaching, painful testicular enlargement may signify cancer. Some initial hydrocele diagnoses appear to be wrong, with missed cancers, suggesting an ultrasound may be useful when a hydrocele diagnosis is uncertain. These results support the existing NICE guidelines, and help to characterise when an ultrasound should be considered in symptomatic men.
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Mucci, Lorelei A., Jacob Hjelmborg, Kathryn Penney, et al. "Familial risk and heritability of genitourinary cancers in the Nordic Twin Cohorts." Journal of Clinical Oncology 33, no. 7_suppl (2015): 11. http://dx.doi.org/10.1200/jco.2015.33.7_suppl.11.

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11 Background: Twin studies estimate familial risk and heritability by leveraging the unique genetic relatedness of twins. We analyzed data from the Nordic Twin Study to investigate the genetic underpinnings of risk of genitourinary cancers. Methods: The cohort included 202,868 monozygotic (MZ) and same-sex dizygotic (DZ) twins from nationwide registries with follow-up via cancer registries. We examined cancers of the prostate, bladder, kidney and testes, and estimated familial risk, risk of a specific cancer in a twin, given that his co-twin was diagnosed with the same cancer, and heritability, the proportion of variation in cancer risk due to genetic differences. Statistical models used time-to-event analyses and accounted for censoring and competing risk of death. Results: During 32 years of follow-up, 5,041 cases of genitourinary cancer were diagnosed. The cumulative incidences in the cohort overall were 10.5% for prostate, 2.2% for bladder, 0.8% for kidney and 0.5% for testes. The strongest familial effects were found for testicular cancer. The familial risks of testicular cancer were 6% for DZ and 14% for MZ twins, i.e. a 12-fold and 28-fold higher risk for DZ and MZ twins, respectively, when their twin was also diagnosed with testicular cancer. Familial risk was also elevated for prostate, bladder, and kidney cancer and showed higher estimates among MZ than DZ twins. Statistically significant estimates of heritability were observed for prostate (57%) and kidney (38%) cancer, while testicular cancer showed evidence of both genetic (37%) and shared environmental (24%) effects. Conclusions: Familial risk estimates provide evidence of significant excess risks for individuals whose siblings develop genitourinary cancers. The higher concordance in MZ vs. DZ twins translated to strong heritability estimates for these malignancies. Results from this study have the potential to be directly translated to clinical practice and genetic counseling, and provide a context for the findings from genome wide association studies.
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Dissertations / Theses on the topic "Testicules – Cancer"

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Dadvar, Ehsan. "Characterization of cancer/testis antigen MAGE-A11 for immunotherapy of prostate cancer." Master's thesis, Université Laval, 2014. http://hdl.handle.net/20.500.11794/26789.

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Les antigènes testiculaires du cancer sont des cibles idéales pour l’immunothérapie du cancer car ce sont des protéines immunogéniques dont l’expression est restreinte aux cellules germinales et au cancer. Le but de cette étude est d’évaluer le potentiel de MAGE-A11, un antigène testiculaire du cancer, comme cible pour développer un vaccin contre le cancer de la prostate. Pour ce faire, l’anticorps monoclonal 5C4 qui a la capacité de reconnaître la présence de MAGE-A11 dans les tissus fixés et inclus en paraffine a été produit. De plus, l’expression de MAGE-A11 a été analysée sur plusieurs lignées de cellules cancéreuses. Il a été démontré que MAGE-A11 est exprimé dans plusieurs types de cancers notamment dans le cancer du côlon et du cerveau. Finalement, nous avons identifié trois épitopes du CMH classe II HLA-DR1 dans la protéine MAGE-A11 confirmant ainsi l’immunogénicité de cet antigène et son potentiel comme cible pour l’immunothérapie du cancer.<br>Cancer/testis antigens are ideal targets for cancer immunotherapy because of their limited expression in normal tissues, aberrant expression in malignancies and their immunogenic properties. The aim of this study was to evaluate the potential of cancer/testis antigen, MAGE-A11, as an immunotherapeutic target for development of a prostate cancer vaccine. To accomplish this, we produced the monoclonal antibody 5C4 that is capable of recognizing MAGE-A11 in formalin-fixed paraffin-embedded tissues. We also investigated the expression of MAGE-A11 in a wide variety of cancer cell lines to determine the scope of its expression in cancer. It was shown that MAGE-A11 is widely expressed in malignancies. The highest MAGE-A11 expression was observed in colon cancer and astrocytoma brain tumors. Finally, we identified three naturally processed MHC class II HLA-DR1 epitopes in MAGE-A11 protein, thus confirming its immunogenicity and its potential as a target for cancer immunotherapy.
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Bergeron, Marie-Ève. "Effet de la cryptorchidie sur le transcriptome testiculaire humain." Master's thesis, Université Laval, 2012. http://hdl.handle.net/20.500.11794/23010.

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Les niveaux d’expression de nombreux gènes peuvent être affectés par l’environnement et mener au développement de la cryptorchidie. Cette malformation congénitale est la plus commune dont une des conséquences majeures est l’infertilité masculine due au testicule non-descendu, auquel un risque plus élevé de cancer testiculaire est associé. L’expression des ARN totaux isolés à partir de biopsies testiculaires ont été analysés par micropuces, puis par une analyse bio-informatique et une validation par RT-qPCR de plusieurs gènes sélectionnés. Ces analyses m’ont permis d’identifier plus de deux milles candidats montrant une expression différente entre des sujets cryptorchides et normaux. Certains de ces gènes sélectionnés peuvent être associés à la descente testiculaire, d’autres au cancer testiculaire ou encore aux divers types cellulaires retrouvés dans cet organe. Les différences dans le transcriptome dues à la cryptorchidie vont nous aider à comprendre la cause génétique de cette maladie.<br>Expression level of numerous genes may be affected by environmental condition and lead to development of cryptorchidism. The most common congenital malformation in male is cryptorchidism. One major consequence of this anomaly is infertility due to undescended testis, to which an increased risk of testicular cancer is associated. Expression of total RNAs isolated from testicular biopsies were analysed with microarray. This was followed by subsequent bioinformatic analysis and RT-qPCR validation of many highlighted genes. Those analyses allowed me to identified more than two thousand genes that showed a differential expression between normal and cryptorchid subjects. Among these highlighted and validated genes, some can be either associated to testicular descent, to testicular cancer, or to specific cell types in testes. Differences in transcriptome due to cryptorchidism should give us clues to identify the genetic causes of this malformation.
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Hoa, Annie. "Epidémiologie du cancer du testicule." Montpellier 1, 1991. http://www.theses.fr/1991MON11224.

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Mings, Christopher. "Athletic Trainers' Knowledge and Perceptions of Testicular Cancer and Testicular Cancer Prevention Practices." Honors in the Major Thesis, University of Central Florida, 2014. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/1623.

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Context: Collegiate male athletes have a higher risk of testicular cancer due to their age group, an increased risk of testicular contusions, and a lack of secondary prevention education. As the athletic training profession increases emphasis on evidence-based practice, it is important for athletic trainers to understand testicular cancer and testicular-self examination as it is outlined within their scope of practice. A general understanding of testicular cancer and the prevention techniques will be important for athletic trainers to promote awareness and health behavior practices. Objective: To examine the athletic trainers' actual knowledge, concern, perceived responsibility, training, feeling of embarrassment, and professional/personal practices. Design: Cross sectional survey. Participants: 249 randomly selected athletic trainers employed in collegiate settings. 65.6% of the respondents reported being between the ages of 21 and 35 years old. Intervention: Actual knowledge, concerned, perceived responsibility, trained, embarrassed, and personal and professional practice behavior scores served as dependent variables. Main Outcome Measures: A Pearson correlation coefficient was calculated between participants' actual knowledge, perceived responsibility, and concerned scores. Two one-way MANOVAs were conducted to determine if there was a difference in actual knowledge, perceived responsibility, and concerned scores that was dependent upon participants' age and gender. Results: Athletic trainers in collegiate settings had a fairly high actual knowledge of testicular cancer (X=7.62[plus or minus]1.42 out of 10). Athletic trainers reported that they should be concerned about testicular cancer in male athletes (X=7.26[plus or minus].167 out of 10). Athletic trainers had a low feeling of responsibility suggested by their reported score (X=3.93[plus or minus]0.18 out of 10). A weak correlation (r(169)=.199, P[less than].009) was found between the actual knowledge and perceived responsibility scores, and between the actual knowledge and concerned scores (r(169)=.285, P[less than]<.001). A medium to strong correlation (r(169)=.486, P[less than].001) was found between the concerned and perceived responsibility scores. Athletic trainers reported a decreased feeling of training about testicular cancer and testicular selfexamination (X=2.28[plus or minus]2.10 out of 10). Also, athletic trainers reported (X=2.71[plus or minus]2.42 out of 10) that they were not embarrassed to discuss testicular cancer. Athletic trainers reported performing either a testicular self-exam or breast-self examination on themselves (X=76%). Conclusions: College athletic trainers have a low feeling of embarrassment, adequate knowledge, and a high feeling of concern regarding testicular cancer, but report a low feeling of perceived responsibility and training.<br>B.S.<br>Bachelors<br>Health Professions<br>Health and Public Affairs<br>Athletic Training
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Falcou, Magali. "Métastases testiculaires du cancer de la prostate : à propos d'un cas et revue de la littérature." Montpellier 1, 1988. http://www.theses.fr/1988MON11037.

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Lutke, Holzik Martijn Frederik. "Genetic predisposition to testicular cancer." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2007. http://irs.ub.rug.nl/ppn/304254797.

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Tuinman, Marrit Annika. "Surviving testicular cancer relationship aspects /." [S.l. : Groningen : s.n. ; University Library of Groningen] [Host], 2008. http://irs.ub.rug.nl/ppn/.

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Calvary, Ronan. "Les tumeurs bilatérales consécutives du testicule : à propos de 7 observations, réflexions sur le carcinome in situ." Bordeaux 2, 1996. http://www.theses.fr/1996BOR2M093.

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Le, Cornet Charlotte. "Évolution du cancer du testicule en Europe : expositions environnementales et professionnelles." Thesis, Lyon 1, 2014. http://www.theses.fr/2014LYO10277/document.

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Les tumeurs germinales du testicule (TGT) représentent le cancer le plus fréquent chez les hommes Européens âgés de 15 et 39 ans. L'incidence a doublé dans la plupart des pays Européens depuis 30 ans. Cette augmentation rapide, les variations géographiques d'incidence et les études chez les populations migrantes suggèrent un rôle des facteurs environnementaux dans le développement des TGT. Cette thèse propose de contribuer à l'amélioration des connaissances concernant l'évolution du TGT en clarifiant l'impact des expositions environnementales et professionnelles, notamment pendant la période prénatale. Les objectifs principaux sont de: 1. Prédire l'incidence du TGT jusqu'en 2025 en estimant la part d'augmentation due aux changements démographiques afin d'obtenir une estimation de l'augmentation due aux risques. 2. Faire un bilan de l'état des connaissances sur l'association entre les expositions environnementales et professionnelles et le développement du TGT dans une revue systématique de littérature 3. Investiguer l'association entre l'exposition parentale professionnelle aux pesticides en période prénatale et le TGT parmi la descendance Les résultats montrent que l'incidence du TGT continue d'augmenter, mettant en avant un fort impact environnemental dans l'évolution du TGT. Néanmoins, la revue de littérature ne permettait pas d'identifier de facteurs de risque environnementaux avérés, mais montrait un manque d'études investiguant les expositions prénatales sur le risque de TGT. L'étude NORD-TEST menée sur les données de registre de quatre pays nordiques est l'étude la plus puissante à ce jour et ne montre aucune association entre l'exposition parentale professionnelle aux pesticides en période prénatale et le TGT<br>Testicular germ cell tumours (TGCT) are the most common cancer diagnosed among young European men aged between 15 and 39 years. TGCT incidence rates have doubled in most European countries over the last 30 years. This rapid increase in incidence, the geographical variations and the studies in migrant populations suggest a role of environmental factors in TGCT aetiology. This thesis aims to contribute to the knowledge of TGCT evolution by studying the impact of environmental and occupational exposures, especially during the prenatal period. The objectives are: 1. To estimate the proportion of the increased incidence due to overall changes in risk patterns compared to the proportion due to demographic changes, by predicting the future testicular cancer trends in Europe 2. To summarize and evaluate the current knowledge on environmental and occupational exposures related to TGCT risk by means of a systematic literature review 3. To investigate the association between the prenatal parental occupational exposure to pesticides and TGCT risk in the offspring. The results show that the TGCT incidence continues to increase, supporting an environmental impact on TGCT evolution. From the epidemiological literature to date no specific environmental risk factors emerge; however, there have clearly been a lack of studies investigating prenatal exposures on TGCT risk. The NORD-TEST study, based on registry data from four Nordic countries, is the largest study to date. No association was found between parental occupational exposure to pesticides during prenatal period and TGCT risk
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Aguilar, Roberto III. "Development of A Testicular Cancer Vaccine." Cleveland State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=csu1461270103.

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Books on the topic "Testicules – Cancer"

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Slan, Linda C. Testicular cancer. U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, National Cancer Institute, 1987.

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Testicular cancer. Rosen Pub., 2011.

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Verville, Kathleen. Testicular cancer. Chelsea House, 2009.

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Houlgatte, Alain. Cancer du testicule. Springer Paris, 2006. http://dx.doi.org/10.1007/2-287-31232-3.

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Campaign, Cancer Research. Testicular cancer - UK. Cancer Research Campaign, 1998.

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Testicular cancer: The essential guide. Need-2-Know, 2012.

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Krege, Susanne, ed. Diagnosis and Management of Testicular Cancer. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-17467-9.

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ed, Khoury Saad, ed. Testicular cancer: Proceedings of the First International Symposium on Testicular Cancer, held in Paris, France, October 8-10, 1984. Liss, 1985.

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International School of Urology and Nephrology. Course. Testicular cancer and other tumors of the genitourinary tract. Plenum Press, 1985.

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Pavone-Macaluso, M., P. H. Smith, and M. A. Bagshaw, eds. Testicular Cancer and Other Tumors of the Genitourinary Tract. Springer US, 1985. http://dx.doi.org/10.1007/978-1-4613-2453-9.

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Book chapters on the topic "Testicules – Cancer"

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Granov, Anatoliy, Leonid Tiutin, and Thomas Schwarz. "Testicular Cancer." In Positron Emission Tomography. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-21120-1_15.

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Liu, Dongyou. "Testicular Cancer." In Tumors and Cancers. CRC Press, 2017. http://dx.doi.org/10.1201/9781315120553-26.

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Reinhardt, M. "Testicular cancer." In PET in Clinical Oncology. Steinkopff, 2000. http://dx.doi.org/10.1007/978-3-642-57703-1_21.

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Rottke, Daniel, and Peter Albers. "Testicular Cancer." In Medical Therapy in Urology. Springer London, 2009. http://dx.doi.org/10.1007/978-1-84882-704-2_4.

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McCaffrey, J. A., and R. J. Motzer. "Testicular Cancer." In Oncologic Therapies. Springer Berlin Heidelberg, 1999. http://dx.doi.org/10.1007/978-3-642-97988-0_33.

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Palmieri, Alessandro, Paolo Verze, and M. Franco. "Testicular Cancer." In Clinical Uro-Andrology. Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-662-45018-5_15.

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Garcia, Michael A., and Alexander R. Gottschalk. "Testicular Cancer." In Handbook of Evidence-Based Radiation Oncology. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-62642-0_28.

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Selek, Ugur. "Testicular Cancer." In Decision Making in Radiation Oncology. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-16333-3_3.

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Ornstein, Moshe C., Navneet S. Majhail, and Timothy Gilligan. "Testicular cancer." In Clinical Manual of Blood and Bone Marrow Transplantation. John Wiley & Sons, Ltd, 2017. http://dx.doi.org/10.1002/9781119095491.ch26.

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Paly, Jonathan J., and Jason A. Efstathiou. "Testicular Cancer." In Clinical Radiation Oncology. John Wiley & Sons, Inc., 2017. http://dx.doi.org/10.1002/9781119341154.ch29.

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Conference papers on the topic "Testicules – Cancer"

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Biggs, Mary, Jacqueline Starr, David Doody, and Stephen Schwartz. "Abstract B127: Alcohol consumption and risk of testicular germ cell carcinoma." In Abstracts: Frontiers in Cancer Prevention Research 2008. American Association for Cancer Research, 2008. http://dx.doi.org/10.1158/1940-6207.prev-08-b127.

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Chia, Victoria, Sabah Quraishi, Barry Graubard, et al. "Abstract A106: Serum testosterone concentrations and risk of testicular germ cell tumors." In Abstracts: Frontiers in Cancer Prevention Research 2008. American Association for Cancer Research, 2008. http://dx.doi.org/10.1158/1940-6207.prev-08-a106.

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Kratz, Christian P., Mark H. Greene, and Jianxin Shi. "Abstract 871: A stratified genetic risk assessment for testicular cancer." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-871.

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Bucher-Johannessen, C., CM Page, TB Haugen, et al. "PO-360 Epigenetic changes in testicular cancer survivors treated with cisplatin." In Abstracts of the 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, The Netherlands, 30 June – 3 July 2018. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/esmoopen-2018-eacr25.389.

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McMaster, Mary L., Ketil R. Heimdal, and Mark H. Greene. "Abstract 2644: No evidence for increased risk of cancers other than testicular cancer among first-degree relatives of testicular germ cell tumor (TGCT) patients from multiple-case TGCT families." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-2644.

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Duangkham, S., A. Wichmann, J. Sekhon, S. Siddiqui, K. Iwuji, and A. Y. Hurtado. "Hemoptysis and Bleomycin Injury in Testicular Cancer: When Pulmonary Metastases Turn Bloody." In American Thoracic Society 2021 International Conference, May 14-19, 2021 - San Diego, CA. American Thoracic Society, 2021. http://dx.doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4930.

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Köroğlu, Pınar. "{Protective Effects of Metformin Against Testicular Damage in Dunning Rat Prostate Cancer Model}." In 15th International Congress of Histochemistry and Cytochemistry. LookUs Scientific, 2017. http://dx.doi.org/10.5505/2017ichc.pp-105.

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Nagahara, Akira, Masashi Nakayama, Daizo Oka, et al. "Abstract 3293: Possible role of SERPINE2 in lymph node metastasis of testicular cancer." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-3293.

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Staruch, Robert, Laura Curiel, Rajiv Chopra, Kullervo Hynynen, and Emad S. Ebbini. "Feasibility of MRI-guided Focused Ultrasound as Organ-Sparing Treatment for Testicular Cancer." In 8TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND. AIP, 2009. http://dx.doi.org/10.1063/1.3131398.

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Schmidtová, S., K. Gerčáková, K. Kaláavská, M. Mego, and L. Kučerová. "PO-478 Chemosensitization of cisplatin-resistant testicular germ cell tumours cells." In Abstracts of the 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, The Netherlands, 30 June – 3 July 2018. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/esmoopen-2018-eacr25.497.

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Reports on the topic "Testicules – Cancer"

1

Walker, Christopher. Incidence of Testicular Cancer in U.S. Air Force Officer Aviators: 1998-2008. Defense Technical Information Center, 2011. http://dx.doi.org/10.21236/ada554672.

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Yambo-Arias, Ramon. Incidence of Testicular Cancer in U.S. Air Force Active Duty Enlisted Male Aircrew. Defense Technical Information Center, 2011. http://dx.doi.org/10.21236/ada547195.

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