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Journal articles on the topic 'Testing of embryotoxicity'

Author: Grafiati

Published: 4 June 2021

Last updated: 8 February 2022

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1

Aikawa, Nobuo, Atsushi Kunisato, Kenji Nagao, Hideaki Kusaka, Katsumi Takaba, and Kinya Ohgami. "Detection of Thalidomide Embryotoxicity by In Vitro Embryotoxicity Testing Based on Human iPS Cells." Journal of Pharmacological Sciences 124, no. 2 (2014): 201–7. http://dx.doi.org/10.1254/jphs.13162fp.

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2

Delaroche, L., P. Oger, E. Genauzeau, et al. "Embryotoxicity testing of IVF disposables: how do manufacturers test?" Human Reproduction 35, no. 2 (2020): 283–92. http://dx.doi.org/10.1093/humrep/dez277.

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Abstract STUDY QUESTION How do manufacturers perform embryotoxicity testing in their quality control programs when validating IVF consumables? SUMMARY ANSWER The Mouse Embryo Assay (MEA) and Human Sperm Survival Assay (HSSA) used for IVF disposables differed from one manufacturer to another. WHAT IS KNOWN ALREADY Many components used in IVF laboratories, such as culture media and disposable consumables, may negatively impact human embryonic development. STUDY DESIGN, SIZE, DURATION Through a questionnaire-based survey, the main manufacturers of IVF disposable devices were contacted during the

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3

Romero, Andrea C., Eugenio Vilanova, and Miguel A. Sogorb. "Shortening and Improving the Embryonic Stem Cell Test through the Use of Gene Biomarkers of Differentiation." Journal of Toxicology 2011 (2011): 1–8. http://dx.doi.org/10.1155/2011/286034.

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The embryonic Stem cell Test (EST) is a validated assay for testing embryotoxicityin vitro. The total duration of this protocol is 10 days, and its main end-point is based on histological determinations. It is suggested that improvements on EST must be focused toward molecular end-points and, if possible, to reduce the total assay duration. Five days of exposure of D3 cells in monolayers under spontaneous differentiation to 50 ng/mL of the strong embryotoxic 5-fluorouracil or to 75 μg/mL of the weak embryotoxic 5,5-diphenylhydeantoin caused between 20 and 74% of reductions in the expression of

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4

Boos, Julia Alicia, Patrick Mark Misun, Astrid Michlmayr, Andreas Hierlemann, and Olivier Frey. "Microfluidic Multitissue Platform for Advanced Embryotoxicity Testing In Vitro." Advanced Science 6, no. 13 (2019): 1900294. http://dx.doi.org/10.1002/advs.201900294.

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5

Aikawa, N. "The development of in vitro embryotoxicity testing using human iPS cells." Toxicology Letters 295 (October 2018): S70. http://dx.doi.org/10.1016/j.toxlet.2018.06.521.

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6

Giavini, Erminio, Maria Luisa Broccia, and Mariangela Prati. "Teratogenicity Testing In Vitro: Post-implantation Whole-embryo Culture." Alternatives to Laboratory Animals 19, no. 1 (1991): 94–98. http://dx.doi.org/10.1177/026119299101900118.

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Various in vitro models have recently been tested for the assessment of developmental toxicity. Since the mechanisms involved in chemically-induced embryotoxicity are complex and numerous, a good in vitro assay must be able to detect developmental toxicants which act via most or all of these mechanisms. The rodent whole-embryo culture seems to fit this requirement, because it undergoes all of the fundamental processes of development. Also physical relationships between cells and tissues are maintained and morphogenesis can proceed normally. In fact, in vitro development of early post-implantat

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7

Bremer, Susanne, Cristian Pellizzer, Sarah Adler, Martin Paparella, and Jan de Lange. "Development of a Testing Strategy for Detecting Embryotoxic Hazards of Chemicals In Vitro by using Embryonic Stem Cell Models." Alternatives to Laboratory Animals 30, no. 2_suppl (2002): 107–9. http://dx.doi.org/10.1177/026119290203002s16.

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The importance of developing in vitro tests for embryotoxicity is discussed, and ECVAM's work with its collaborators is summarised. Studies are in progress to find new endpoints for use in the scientifically validated embryonic stem (ES) cell test, so that the potential for chemical effects on endodermal, mesodermal and/or ectodermal differentiation can be identified. This involves, inter alia, the use of genetically modified ES cells.

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8

Prelusky, Dan B., Robert M. G. Hamilton, Brian C. Foster, Locksley H. Trenholm, and Brian K. Thompson. "Optimization of Chick Embryotoxicity Bioassay for Testing Toxicity Potential of Fungal Metabolites." Journal of AOAC INTERNATIONAL 70, no. 6 (1987): 1049–55. http://dx.doi.org/10.1093/jaoac/70.6.1049.

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Abstract The optimization of a simple, sensitive procedure using a chick embryotoxicity screening test (CHEST) bioassay for detection of toxic compounds is presented. Dosing protocols of eggs, using several mycotoxins (aflatoxin B„ deoxynivalenol, T-2 toxin) and appropriate controls, were evaluated for embryonic sensitivity, overall practicality of the procedure, and consistency of results. It was found that both type of carrier solvent and volume injected could significantly affect overall embryonic mortality. The chick embryo was most sensitive to the effects of toxins and solvents after 1 o

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9

Babić, Sanja, Josip Barišić, Draženka Stipaničev, et al. "Assessment of river sediment toxicity: Combining empirical zebrafish embryotoxicity testing with in silico toxicity characterization." Science of The Total Environment 643 (December 2018): 435–50. http://dx.doi.org/10.1016/j.scitotenv.2018.06.124.

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10

Schrattenholz, Andre. "Proteomic surrogate biomarkers for in vitro testing of embryotoxicity: Quantitative differential investigation of ESC models." Toxicology Letters 189 (September 2009): S31. http://dx.doi.org/10.1016/j.toxlet.2009.06.058.

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11

Vogel, R., K. Fleischhauer, and H. Spielmann. "Embryotoxicity testing of sera from patients receiving cytostatic therapy using preimplantation mouse embryos in vitro." Mutation Research/Environmental Mutagenesis and Related Subjects 234, no. 6 (1990): 416–17. http://dx.doi.org/10.1016/0165-1161(90)90156-i.

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12

Jayasinghe, Chanika D., and Uthpala A. Jayawardena. "Toxicity Assessment of Herbal Medicine Using Zebrafish Embryos: A Systematic Review." Evidence-Based Complementary and Alternative Medicine 2019 (November 6, 2019): 1–17. http://dx.doi.org/10.1155/2019/7272808.

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Herbal remedies have been practiced by humans over centuries and therefore possess time-proven safety. However, it is imperative to evaluate the toxic effects of herbal medicine to confirm their safety, particularly when developing therapeutic leads. Use of laboratory animals such as rats, mice, and rabbits was considered as gold standard in herbal toxicity assessments. However, in the last few decades, the ethical consideration of using higher vertebrates for toxicity testing has become more contentious. Thus, possible alternative models entailing lower vertebrates such as zebrafish were intr

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13

Imai, Koichi, and Masaaki Nakamura. "In vitro embryotoxicity testing of metals for dental use by differentiation of embryonic stem cell test." Congenital Anomalies 46, no. 1 (2006): 34–38. http://dx.doi.org/10.1111/j.1741-4520.2006.00099.x.

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14

Annamaria, Volpi Ghirardini, Losso Chiara, Arizzi Novelli Alessandra, Baù Alvise, Edouard His, and Ghetti Pier Francesco. "Mytilus galloprovincialisas bioindicator in embryotoxicity testing to evaluate sediment quality in the lagoon of Venice (Italy)." Chemistry and Ecology 21, no. 6 (2005): 455–63. http://dx.doi.org/10.1080/02757540500438516.

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15

Collins, Thomas F. X., Robert L. Sprando, Deborah L. Hansen, Mary E. Shachelford, and John J. Welsh. "Testing Guidelines for Evaluation of Reproductive and Developmental Toxicity of Food Additives in Females." International Journal of Toxicology 17, no. 3 (1998): 299–325. http://dx.doi.org/10.1080/109158198226594.

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The original Redbook issued by the Food and Drug Administration in 1982 pro-vided guidelines for testing the effects of direct food additives and color additives on mothers and developing embryos. The tests included brief teratol-ogy/developmental toxicity studies and longer studies spanning several generations called multigeneration reproduction studies. In 1993, the draft version of Redbook II was made available for public comment. In it, the revised chapter on reproduction and developmental toxicity is the result of extensive literature review and public comment. It includes discussions of

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16

Greenlee, A. R., T. A. Kronenwetter-Koepel, S. J. Kaiser, T. M. Ellis, and K. Liu. "Combined effects of MatrigelTM and growth factors on maintaining undifferentiated murine embryonic stem cells for embryotoxicity testing." Toxicology in Vitro 18, no. 4 (2004): 543–53. http://dx.doi.org/10.1016/j.tiv.2004.01.013.

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17

Vogel, R., and H. Spielmann. "In vitro system for embryotoxicity testing during the preimplantation period using serum supplement from in vivo exposed humans or animals." Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 181, no. 2 (1987): 326. http://dx.doi.org/10.1016/0027-5107(87)90144-8.

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18

Niggeschulze, Adolf, and Alexander Kast. "Maternal age, reproduction and chromosomal aberrations in Wistar derived rats." Laboratory Animals 28, no. 1 (1994): 55–62. http://dx.doi.org/10.1258/002367794781065717.

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The fertility of rats ranges from one to 18 months. In standard teratogenicity testing young, mature females are used which may not reflect the situation in women above 35 years old. Reproduction among different age groups of Wistar ats (strain Chbb : THOM) was compared at 3, 6, 9, 12, 15 and 18 months. At least 20 virgin females were inseminated per age group. The copulation rate did not differ between the groups. From the maternal age of 12 months, the pregnancy rate was significantly decreased, from the age of 9 months, the litter values were significantly lowered and the resorption rates w

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19

Lovinskaya, Anna V., Saule Zh Kolumbayeva, Maria A. Suvorova, Akerke I. Iliyassova, Zarema M. Biyasheva, and Serikbay K. Abilev. "Complex study of potential toxicity and genotoxicity of water samples from natural sources of the suburban zone of Almaty." Ecological genetics 17, no. 2 (2019): 69–81. http://dx.doi.org/10.17816/ecogen17269-81.

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Background. Natural aquatic ecosystems are the habitat of many organisms, a source of drinking water, a resource for human activities and are subjected to anthropogenic pressure. In this regard, interest in studying the genotoxicity and mutagenicity of surface waters has increased significantly. The aim of this study is to investigate the cytotoxic, genotoxic and mutagenic effects of the surface waters of the suburban area of Almaty. Material and methods. The research materials were water samples of the rivers Esik, Turgen and Lake Esik. The atomic absorption method, lux-test, cytogeneti

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20

Festag, Matthias, Bruno Viertel, Pablo Steinberg, and Claudia Sehner. "An in vitro embryotoxicity assay based on the disturbance of the differentiation of murine embryonic stem cells into endothelial cells. II. Testing of compounds." Toxicology in Vitro 21, no. 8 (2007): 1631–40. http://dx.doi.org/10.1016/j.tiv.2007.06.014.

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21

Pikula, Konstantin, Alexander Zakharenko, Vladimir Chaika, et al. "Toxicity of Carbon, Silicon, and Metal-Based Nanoparticles to Sea Urchin Strongylocentrotus intermedius." Nanomaterials 10, no. 9 (2020): 1825. http://dx.doi.org/10.3390/nano10091825.

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With the increasing annual production of nanoparticles (NPs), the risks of their harmful influence on the environment and human health are rising. However, our knowledge about the mechanisms of interaction between NPs and living organisms is limited. Prior studies have shown that echinoderms, and especially sea urchins, represent one of the most suitable models for risk assessment in environmental nanotoxicology. To the best of the authors’ knowledge, the sea urchin Strongylocentrotus intermedius has not been used for testing the toxicity of NPs. The present study was designed to determine the

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22

Teixidó, Elisabet, David Leuthold, Alexander Amberg, Andreas Czich, Eckart Krupp, and Stefan Scholz. "ZFminus1: A strategy to reduce animal tests for developmental toxicity testing by a combined use of mammalian models and the zebrafish embryotoxicity test (ZFET or ZETA)." Reproductive Toxicology 64 (September 2016): 22. http://dx.doi.org/10.1016/j.reprotox.2016.06.048.

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23

de Jong, Esther, Marta Barenys, Sanne A. B. Hermsen, et al. "Comparison of the mouse Embryonic Stem cell Test, the rat Whole Embryo Culture and the Zebrafish Embryotoxicity Test as alternative methods for developmental toxicity testing of six 1,2,4-triazoles." Toxicology and Applied Pharmacology 253, no. 2 (2011): 103–11. http://dx.doi.org/10.1016/j.taap.2011.03.014.

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24

Teixidó, Elisabet, David Leuthold, Alexander Amberg, Andreas Czich, Eckart Krupp, and Stefan Scholz. "ZFminus1: A strategy to reduce animal tests for developmental toxicity testing by a combined use of mammalian models and the zebrafish embryotoxicity test (ZFET or ZETA). Selection of model compounds." Reproductive Toxicology 64 (September 2016): 29. http://dx.doi.org/10.1016/j.reprotox.2016.06.062.

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25

Owen, K., K. Hartley, ML Tucker, MM Parkinson, DJ Tweats, and MR Jackson. "The preclinical toxicological evaluation of sumatriptan." Human & Experimental Toxicology 14, no. 12 (1995): 959–73. http://dx.doi.org/10.1177/096032719501401205.

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1 Sumatriptan is a potent and selective 5-HT1 receptor agonist marketed for the treatment of migraine by both oral and subcutaneous routes. An extensive toxicologi cal programme employing high doses of sumatriptan was carried out in a range of animal species. The stud ies evaluated both the local and systemic tolerance to single and repeated dosing, effects on all stages of repro duction, as well as the genotoxic and oncogenic poten tial of sumatriptan. 2 The administration of relatively high single and repeat ed doses of sumatriptan was well tolerated by both rodents and dogs by the oral, sub

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26

Adler, Sarah, Martin Paparella, Cristian Pellizzer, Thomas Hartung, and Susanne Bremer. "The Detection of Differentiation-inducing Chemicals by using Green Fluorescent Protein Expression in Genetically Engineered Teratocarcinoma Cells." Alternatives to Laboratory Animals 33, no. 2 (2005): 91–103. http://dx.doi.org/10.1177/026119290503300204.

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The murine embryonal teratocarcinoma cell line, P19, was genetically manipulated in order to provide preliminary information on compounds that induce differentiation. Without chemical induction, P19 cells remain in an undifferentiated state, but can be induced to differentiate into specific cell types. For example, dimethyl sulphoxide (DMSO) induces cardiac and skeletal muscle differentiation, whereas retinoic acid stimulates neuronal differentiation. P19 cells were transfected with a construct containing a segment of the murineTert (mTert) promoter sequence combined with the green fluorescent

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27

Greenlee, A. R., T. A. Kronenwetter-Koepel, S. J. Kaiser, T. M. Ellis, and K. Liu. "Corrigendum to “Combined effects of Matrigel™ and growth factors on maintaining undifferentiated murine embryonic stem cells for embryotoxicity testing” [Toxicology in Vitro 18 (2004) 543–553] and “Comparison of Matrigel™ and gelatine substrata for feeder-free culture of undifferentiated mouse embryonic stem cells for toxicity testing” [Toxicology in Vitro 19 (2005) 389–397]." Toxicology in Vitro 21, no. 8 (2007): 1695. http://dx.doi.org/10.1016/j.tiv.2007.08.021.

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28

Kamelia, Lenny. "Prenatal developmental toxicity testing of petroleum substances using the zebrafish embryotoxicity test." ALTEX, 2018. http://dx.doi.org/10.14573/altex.1808121.

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29

Kamelia, Lenny. "Prenatal developmental toxicity testing of petroleum substances using the zebrafish embryotoxicity test_suppl." ALTEX, 2018. http://dx.doi.org/10.14573/altex.1808121s.

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30

Fakri, Fajar, Loly Subhiaty Idrus, Maria Alexandra Iskandar, Indra Wibowo, and I. Ketut Adnyana. "Acute Toxicity of Keladi Tikus (Typhonium flagelliforme (Lodd.) Blume) Ethanol Extract on Zebrafish (Danio rerio) Embryo In Vivo." Indonesian Journal of Pharmacy, December 28, 2020. http://dx.doi.org/10.22146/ijp.1121.

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Keladi tikus (Typhonium flagelliforme (Lodd.) Blume) is an Indonesian medicinal plant that has various pharmacological properties. Zebrafish (Danio rerio) has been proposed as a model that can bridge the gap between cell assays and rodent assays. Evaluation of the toxic effects of natural products using the Zebrafish model can be assessed starting from the blastula stage of embryonic development. This study aims to investigate the potential acute toxicity effect of keladi tikus-ethanol extract (KTEE) using zebrafish embryos. A static non-replacement regime for acute toxicity testing was used.

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