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Relevant bibliographies by topics / Tetanus-Toxin / Dissertations / Theses

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Dissertations / Theses on the topic 'Tetanus-Toxin'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Michaelides, Alecos. "Chemical and enzymatic fragmentation of tetanus toxin and immunological studies on anti-tetanus toxin and toxoid sera." Thesis, University of Ottawa (Canada), 1996. http://hdl.handle.net/10393/9661.

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This thesis describes the immunization protocols for the production of antibodies against tetanus toxin and toxoid in guinea pigs and mice. Antibodies were successfully raised against the toxin without mortalities in either species. The murine sera obtained, were isotyped by ELISA and the toxin was proven to be a superior antigen in eliciting production of IgG$\rm\sb{2a}$ and IgG$\sb3$. The two isotypes which have demonstrated antitumor activity. The anti-toxoid sera exhibited a lower reactivity towards the toxin and toxoid when compared with anti-toxin sera. The reactivity of recombinant teta

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2

Johnston, Louise. "Transcutaneous immunisation with antigens derived from tetanus toxin." Thesis, Imperial College London, 2008. http://hdl.handle.net/10044/1/4657.

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Transcutaneous immunisation (TCI) is a novel needle-free method of vaccine delivery, which involves the application of soluble antigens onto the surface of intact skin. In this thesis, the immunogenicity and neutralising potency of tetanus neurotoxin (TeNT) fragments were compared to that of tetanus toxoid (TTxd) following TCI. In addition, to understand the mechanisms of induction of immune response by TCI, in vitro and in vivo interaction of tetanus proteins with skin immune cells was also investigated. The 50kDa recombinant carboxyl-terminal fragment of tetanus toxin (HCWT) and a 50kDa HC m

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3

Sheppard, A. J. "Studies on production and characterisation of monoclonal antibodies to tetanus toxin, and their use for developing immunopurified tetanus toxoid and toxin." Thesis, Open University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235280.

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4

Sundstrom, Lars Eric. "An electrophysiological study of tetanus toxin-induced hippocampal epilepsy." Thesis, University of Oxford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.256376.

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5

Colville, Caroline Anne. "The interaction of tetanus toxin with adrenal chromaffin cells." Thesis, University of Edinburgh, 1992. http://hdl.handle.net/1842/19641.

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Tetanus toxin exerts its primary biological effect by impairing the release of inhibitory neurotransmitters in the central nervous system; the mechanism of this blockade, however, remains unknown. Studies using adrenal medullary chromaffin cells, which are closely related to the toxin's target neurones but much more accessible to biochemical investigation, have the potential to provide information on various aspects of the intoxication process of tetanus. Nicotine-evoked (but not basal) secretion of catecholamines from intact chromaffin cells was inhibited by tetanus toxin in a dose-dependent

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6

Scott, Nathan. "Anti-tetanus toxin chelating recombinant antibodies by phage display." Thesis, Imperial College London, 2008. http://hdl.handle.net/10044/1/4638.

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Chelating Recombinant Antibodies (CRAbs) are a form of high affinity tandem single chain antibody (scFv) with two component scFvs which target non‐overlapping epitopes on the same antigen molecule. The optimised inter‐scFv linker allows simultaneous engagement of the scFvs resulting in a synergistic improvement in affinity. High affinity is a desirable characteristic in therapeutic antibodies since it strongly correlates with improved potency. Building upon previous work, this thesis describes the development of a phage‐display based approach toward isolating CRAbs with both the optimal scFv p

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7

Parton, Robert Glenn. "The binding and internalisation of tetanus toxin by neuronal tissue." Thesis, University of Leicester, 1987. http://hdl.handle.net/2381/35122.

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8

Sweeney, Sean Thomas. "Targetted expression of tetanus toxin light chain in Drosophilia melanogaster." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627065.

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9

Andreu, Alice. "Tetanus toxin fragment C as a targeting moiety for gene delivery." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419230.

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10

Box, Michael Andrew. "Characterisation of the binding properties and gene delivery potential of tetanus toxin." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248341.

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11

Figueiredo, Dayse Maria De Magalhaes. "Characterization of tetanus toxin derivates suitable for the delivery of therapeutic proteins." Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243965.

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12

Finnerty, Gerald Thomas. "Factors determining the transition to seizure in the tetanus toxin model of epilepsy." Thesis, Imperial College London, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361453.

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13

Qazi, Omar. "Ganglioside binding, immunological and structural properties of the Hc fragment of tetanus toxin." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414409.

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14

Foss, Lucy Jane. "Effects of tetanus toxin on synaptic proteins in models of temporal lobe epilepsy." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4530/.

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Injection of tetanus toxin (TeNT), systemically or directly into the brain, has long been known to cause spastic paralysis or seizures respectively: thought to be due to disruption of inhibitory neurons and cleavage of vesicle associated membrane protein 2 (VAMP2). Here we investigate mechanisms involved in TeNT-induced chronic epilepsy in the first 16 days following injections in vivo and focally onto organotypic hippocampal slice cultures. Immunohistochemical analysis identified a spatial and temporal cleavage of both VAMP1 and VAMP2 progressing from day 2 post injection through to days 8 an

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15

Bohnert, Stephanie Anne. "Characterisation of the axonal transport dynamics of tetanus toxin in health and disease." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445322/.

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Tetanus toxin is internalised at the neuromuscular junction into vesicular carriers undergoing fast retrograde transport to the spinal cord. We determined the pH regulation of this compartment in living motor neurons using a chimera of the tetanus toxin binding fragment (TeNT He) and a pH-sensitive variant of the green fluorescent protein (ratiometric pHluorin). We have demonstrated that moving retrograde carriers display a narrow range of neutral pHs, which is kept constant during transport. Stationary TeNT Hc-positive organelles instead exhibit a wide spectrum of pHs, ranging from acidic to

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16

Aliprandini, Eduardo. "Obtenção de anticorpos monoclonais humanos antitetânicos." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-04122015-141425/.

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Anticorpos monoclonais (AcMos) para uso terapêutico correspondem a uma área importante na indústria de biofármacos, em especial os AcMos humanos, que apresentam menor probabilidade de elicitar imunogenicidade. O objetivo deste trabalho consistiu em obter AcMos humanos antitetânicos através da separação de linfócitos B produtores de anticorpos específicos utilizando o antígeno ou de plasmablastos. As células foram coletadas de doadores após vacinação e separadas por equipamento de cell sorter. As regiões variáveis dos anticorpos foram amplificadas e clonadas em vetores de expressão, que foram u

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17

Fratelli, Fernando. "Avaliação da produção de toxina tetânica por \"Clostridium tetani\" cultivado por processos fermentativos descontínuo e descontínuo alimentado." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/9/9134/tde-06122007-163303/.

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A toxina tetânica é uma proteína sintetizada pelo bacilo Clostridium tetani que após destoxificação através da ação do formol, continua apresentando propriedades antigênicas e imunogênicas, obtendo a denominação toxóide tetânico. A síntese dessa proteína ocorre quando esse bacilo encontra-se na sua forma vegetativa e em meio de cultura específico relativamente complexo contendo glicose e peptonas. O efeito simultâneo de diferentes níveis de glicose (Go) e N-Z Case TT® (NZo) como fontes de carbono e nitrogênio, respectivamente, na produção de toxina tetânica foi investigada nesta primeira parte

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18

Chivet, Mathilde. "Exosomes neuronaux : rôle dans le passage intercellulaire de protéines et d'ARN." Phd thesis, Université de Grenoble, 2013. http://tel.archives-ouvertes.fr/tel-00905660.

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Les exosomes sont des vésicules d'origine endocytaire sécrétées par les cellules dans leur environnement après fusion des endosomes multivésiculés avec la membrane plasmique. Ils représentent un nouveau moyen de communication cellulaire par le transfert intercellulaire de protéines, de lipides et d'ARN. Dans le laboratoire, nous nous intéressons aux rôles que pourraient jouer les exosomes neuronaux dans le système nerveux central. Nous avons montré que les neurones matures sécrètent des exosomes. Nous avons mis en évidence que cette sécrétion est directement reliée à l'activité synaptique glut

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19

Jacquier, Muriel. "Association covalente de C3b à la toxine tétanique : rôle dans l'apprêtement et la présentation de l'antigène aux lymphocytes T." Grenoble 1, 1992. http://www.theses.fr/1992GRE10200.

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Le travail presente constitue une premiere etape dans l'etude du role du ligand bifonctionnel c3b associe la toxine tetanique, sur la fonction d'appretement et de presentation de cet antigene par des clones b humains transformes par le virus d'epstein-barr, specifiques de la toxine tetanique, aux lymphocytes t. Dans une premiere partie, l'analyse en sds-page des fragments de c3b fixes sur les lymphocytes b indique que 60% de cette proteine est impliquee dans la formation de complexes covalents par pont disulfure avec des proteines membranaires et 40% dans des interactions non covalentes avec l

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20

Brüggemann, Holger. "Die vollständige Entschlüsselung der Genomsequenz des Tetanus-Erregers Clostridium tetani und die Analyse seines genetischen Potentials." Doctoral thesis, 2003. http://hdl.handle.net/11858/00-1735-0000-0006-AE61-8.

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21

Demeterová, Ľubica. "Morfologické zmeny hipokampu v tetanotoxínovom modeli temporálnej epilepsie." Master's thesis, 2015. http://www.nusl.cz/ntk/nusl-331090.

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Temporal lobe epilepsy is the most common form of epilepsy and hippocampal sclerosis represents the main underlying structural abnormity. Approximately 20% of TLE cases are non- lesional due to absence of any obvious epileptogenic lesion and tetanus toxin model is traditionally considered as a model of non-lesional temporal lobe epilepsy. The main aim of this study was to evaluate the presence of the cell damage and to determine its spatiotemporal profile. Tetanus toxin was stereotaxically injected into CA3 subregion of dorsal hippocampus in adult male Wistar rats. Brain tissue was extracted 4

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