Relevant bibliographies by topics / Tetrahydrocurcumin

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers
  5. Reports

Academic literature on the topic 'Tetrahydrocurcumin'

Author: Grafiati
Published: 4 June 2021
Last updated: 26 July 2025

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Journal articles on the topic "Tetrahydrocurcumin"

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González, Yisett, Randy Mojica-Flores, Dilan Moreno-Labrador, et al. "Tetrahydrocurcumin Derivatives Enhanced the Anti-Inflammatory Activity of Curcumin: Synthesis, Biological Evaluation, and Structure–Activity Relationship Analysis." Molecules 28, no. 23 (2023): 7787. http://dx.doi.org/10.3390/molecules28237787.

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Tetrahydrocurcumin, the most abundant curcumin transformation product in biological systems, can potentially be a new alternative therapeutic agent with improved anti-inflammatory activity and higher bioavailability than curcumin. In this article, we describe the synthesis and evaluation of the anti-inflammatory activities of tetrahydrocurcumin derivatives. Eleven tetrahydrocurcumin derivatives were synthesized via Steglich esterification on both sides of the phenolic rings of tetrahydrocurcumin with the aim of improving the anti-inflammatory activity of this compound. We showed that tetrahydr
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Lai, Ching-Shu, Chi-Tang Ho, and Min-Hsiung Pan. "The Cancer Chemopreventive and Therapeutic Potential of Tetrahydrocurcumin." Biomolecules 10, no. 6 (2020): 831. http://dx.doi.org/10.3390/biom10060831.

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In recent decades, cancer has been one of the leading causes of death worldwide. Despite advances in understanding the molecular basis of tumorigenesis, diagnosis, and clinical therapies, the discovery and development of effective drugs is an active and vital field in cancer research. Tetrahydrocurcumin is a major curcuminoid metabolite of curcumin, naturally occurring in turmeric. The interest in tetrahydrocurcumin research is increasing because it is superior to curcumin in its solubility in water, chemical stability, bioavailability, and anti-oxidative activity. Many in vitro and in vivo st
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Rege, Sameera A., Megha A. Varshneya, and Shamim A. Momin. "A Mini-Review: Comparison between curcumin and tetrahydrocurcumin based on their activities." Croatian journal of food science and technology 13, no. 1 (2021): 128–32. http://dx.doi.org/10.17508/cjfst.2021.13.1.16.

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Curcumin, a natural ingredient present in turmeric rhizome is known for its various therapeutic activities such as antioxidant, anti-inflammatory, anticancer, antidiabetic, NF-kB activation suppresser. The hydrogenated derivative of curcumin, i.e., tetrahydrocurcumin, is also found to reveal the same activities. Moreover, the pro-oxidant effect of curcumin is reported, whereas tetrahydrocurcumin does not show any pro-oxidant effects. This contrasting behaviour of the two is attributed to their structures, because conjugation is involved only in curcumin, not in the tetrahydrocurcumin. It can b
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Fai, Tan Kin, Goh Hui Yee, Palanirajan Vijayaraj Kumar та Manogaran Elumalai. "Preparation of Chitosan Particles as a Delivery System for Tetrahydrocurcumin: β-cyclodextrin Inclusive Compound for Colorectal Carcinoma". Current Drug Therapy 16, № 5 (2021): 430–38. http://dx.doi.org/10.2174/1574885516666211210153741.

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Background: Tetrahydrocurcumin is a hydrogenated active metabolite of curcumin that exhibits similar pharmacological effects to curcumin. However, its hydrophobic nature has limited its aqueous solubility and bioavailability. By incorporating the tetrahydrocurcumin into β-cyclodextrin, its physiochemical property can be improved. Objective: To develop a chitosan composite loaded with tetrahydrocurcumin inclusive complex, characterize the developed composites, and evaluate its effectiveness on cancer cells. Methods: Tetrahydrocurcumin was formulated into an inclusive complex with β-cyclodextrin
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Shimoda, Kei, Naoji Kubota, Yuya Fujitaka та ін. "Production of Tetrahydrocurcumin From Curcumin by Cultured Plant Cells and Inhibitory Effects of Curcuminoids on NF-κB Activity". Natural Product Communications 14, № 9 (2019): 1934578X1987892. http://dx.doi.org/10.1177/1934578x19878920.

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Biotransformation of curcumin was investigated using cultured plant cells of Morus sp. Cultured Morus cells converted curcumin into dihydrocurcumin and tetrahydrocurcumin. The activity of nuclear factor-κB was inhibited by curcumin and tetrahydrocurcumin.
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Devaki, Jorapur, Dr Satish Pavuluri, and Savalgi Sonali. "DEVELOPMENT AND VALIDATION OF THE UV-SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF TETRAHYDROCURCUMIN." Tropical Journal of Pharmaceutical and Life Sciences 10, no. 3 (2023): 27–37. https://doi.org/10.61280/tjpls.v10i3.124.

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The main objective is to develop and validate the UV-spectrophotometric method for the estimation of Tetrahydrocurcumin as per ICH guidelines. Materials and Methods: A simple, rapid, accurate, and economical UV-spectrophotometric method has been developed for the estimation of tetrahydrocurcumin. Results: Theλ max of tetrahydrocurcumin was found to be 280nm. The drug follows linearity in the concentration range 2-12 µg mL-1 with a correlation coefficient value of 0.9975. The accuracy of the method was checked by recovery experiment performed at three different levels, i.e., 50%,100% and 120%.
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Azeredo, Patrícia dos Santos, Charity Fix, Laena Pernomian, et al. "Tetrahydrocurcumin Outperforms Curcumin in Preventing Oxidative Stress-Induced Dysfunction in Tert-Butyl Hydroperoxide-Stimulated Cardiac Fibroblasts." International Journal of Molecular Sciences 26, no. 13 (2025): 5964. https://doi.org/10.3390/ijms26135964.

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Oxidative stress is a common feature of various pathological conditions, including tissue remodeling and dysfunction. Cardiac fibroblasts, which play a key role in maintaining extracellular matrix homeostasis, are sensitive to oxidative injury. Curcumin and tetrahydrocurcumin are plant-derived polyphenols with antioxidant properties, yet their relative efficacy in preventing oxidative stress–induced dysfunction in cardiac fibroblasts remains unclear. In this study, cardiac fibroblasts were treated with curcumin or tetrahydrocurcumin prior to exposure to tert-butyl hydroperoxide (t-BHP), a wide
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Shimoda, Kei, Naoji Kubota, Hirotaka Hirano, Masahiro Matsumoto, Hatsuyuki Hamada, and Hiroki Hamada. "Formation of Tetrahydrocurcumin by Reduction of Curcumin with Cultured Plant Cells of Marchantia Polymorpha." Natural Product Communications 7, no. 4 (2012): 1934578X1200700. http://dx.doi.org/10.1177/1934578x1200700428.

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Cultured plant cells of Marchantia polymorpha, Nicotiana tabacum, Phytolacca americana, Catharanthus roseus, and Gossypium hirsutum were examined for their ability to reduce curcumin. Only M. polymorpha cells converted curcumin into tetrahydrocurcumin in 90% yield in one day. Time-course experiment revealed a two-step formation of tetrahydrocurcumin via dihydrocurcumin.
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Boli, Lusia Silfia Pulo, Nufida Dwi Aisyah, Vera Khoirunisa, Heni Rachmawati, Hermawan Kresno Dipojono, and Febdian Rusydi. "Solvent Effect on Bond Dissociation Enthalpy (BDE) of Tetrahydrocurcumin: A Theoretical Study." Materials Science Forum 966 (August 2019): 215–21. http://dx.doi.org/10.4028/www.scientific.net/msf.966.215.

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Solvent effect on bond dissociation enthalpy (BDE) of different functional groups of tetrahydrocurcumin is investigated. This is to evaluate how the polarity of a medium affect BDE and to clarify which functional groups hold the key role in its antioxidant activity through hydrogen transfer. We occupy density functional theory to calculate BDE through geometrical optimization and frequency calculation at six sites of tetrahydrocurcumin in water, methanol and chloroform solvents. The solvents represent polar and non-polar medium. Our result shows that BDE is lower in non-polar medium and hydrog
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Lamb, Steven R., and S. Mark Wilkinson. "Contact allergy to tetrahydrocurcumin." Contact Dermatitis 48, no. 4 (2003): 227. http://dx.doi.org/10.1034/j.1600-0536.2003.00062.x.

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Dissertations / Theses on the topic "Tetrahydrocurcumin"

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Loron, Anne. "Chitosan polymers and plant extracts to develop biofungicides." Thesis, Bordeaux, 2021. http://www.theses.fr/2021BORD0002.

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Les cultures céréalières sont sujettes aux invasions de champignons pathogènes, ce qui altère la qualité des grains et pose un problème de santé publique, en raison de mycotoxines potentiellement contenues dans ces grains. Face à la prise de conscience publique et politique de la nécessité d’inclure la composante environnementale dans nos modes de consommation et de production, les fongicides synthétiques traditionnels se voient petit à petit remplacés par des alternatives plus « vertes ». Dans ce contexte, ce travail de thèse a pour but de créer une formulation à base de produits renouvelable
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Pendleton, Emily Grace. "The Effect of Curcumin and Tetrahydrocurcumin in Combination with 5-fluorouracil on Esophageal Cancer Cell Lines." Bowling Green State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1431601435.

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Liu, Sheng-Yang, and 劉聖揚. "Effects of 3-deoxy-3-amino tetrahydrocurcumin, the aminated metabolite of tetrahydrocurcumin on inflammation-related pathways." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/9jp466.

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碩士<br>國立臺灣大學<br>食品科技研究所<br>107<br>Inflammation is a defense mechanism, which is beneficial to organism, usually occurs during tissue damage or pathogenic invasion, in order to promote repair and regeneration, and lead to neutralization and removal of harmful stimuli or pathogens. Nonetheless, chronic inflammation has also been pointed out to be highly related to several diseases. Therefore, evaluation of anti-inflammatory capability has become a basic starting point or indicator in early research of inflammation-related diseases before further investigating the preventive potential of a sample
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Chan, Cheng-Yuan, and 詹政原. "The anticancer activity effects of tetrahydrocurcumin in human hepatocellular carcinoma cells." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/63534422777109198126.

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碩士<br>國立中興大學<br>生命科學系所<br>101<br>Hepatocellular carcinoma(HCC) is among the most lethal and prevalent cancers in human epidemiology. On the choice of drugs, Tetrahydrocurcumin has been demonstrated to be the major metabolite of curcumin.Curcumin is a natural polyphenol compound of yellow pigment, derived from the rhizome of the Curcuma longa plant. According to previous studies found that the pharmacological activity of curcumin is not stable in vivo. Furthermore,it is difficulty absorbed through the gastrointestinal tract. Acting on the blood concentration is not high thus may result in limit
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Wu, Jia-Ching, and 吳家慶. "Tetrahydrocurcumin and curcumin as cancer chemopreventive agents and the underlying molecular mechanism." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/06932097409221091330.

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碩士<br>國立高雄海洋科技大學<br>水產食品科學研究所<br>98<br>Part I: Tetrahydrocurcumin, curcumin major metabolite, induced autophagic cell death through PI3K-Akt-mTOR and MAPKs signaling pathway in human HL-60 promyelocytic leukemia cells Autophagy (programmed cell death type II) is crucial for maintaining cellular homeostasis. In addition, several autophagy-deficient or knockout studies indicating that autophagy as a tumor suppressor. Tetrahydrocurcumin (THC), a major metabolite of curcumin (CUR), has been demonstrated with anti-migration and antioxidation in vivo. In the present study, we found that treatme
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TSAI, SIAO-PING, and 蔡曉萍. "Antifibrotic efficacy and molecular mechanisms on tetrahydrocurcumin (THC), the major metabolite of curcumin." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/04325494688345918203.

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碩士<br>國立高雄海洋科技大學<br>水產食品科學研究所<br>104<br>Tetrahydrocurcuin (THC), a major metabolite of curcumin, with high bioavailability and strong antioxidant property. According to a previous study, THC exhibited in vivo hepatoprotective and antifibrotic effects against liver injury induced by dimethylnitrosamine (DMN). In the present study, the protective effect and molecular mechanism of THC was investigated on carbontetrachloride (CCl4)-induced liver fibrosis in Sprague-Dawley (SD) rats. Our data showed that the administration of THC at doses of 10 and 50 mg/kg significantly reduced the elevated serum
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LIU, CHAO-YUN, and 劉棹雲. "Reversal effects of tetrahydrocurcumin (THC) in hepatic fibrosis by regulating autophagy in hepatic stellate cells." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/f2695h.

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碩士<br>國立高雄海洋科技大學<br>水產食品科學研究所<br>106<br>Tetrahydrocurcumin (THC) is a major metabolite of curcumin and shows better biological activities and bioavailability than curcumin. Previous research has demonstrated that THC has anti-fibrotic effects, but the molecular mechanism is unknown. This study is design to investigate the reversal effect of THC in hepatic fibrosis by regulating autophagy in hepatic stellate cells in vitro and in vivo. In in vitro, THC significantly attenuated expression of α-SMA and the degradation of lipid droplet in TGF-β1 activated HSC-T6 cells. Further experiments showed t
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WU, LI-MEI, and 吳麗美. "Mechanisms and effective of the tetrahydrocurcumin (THC) inhibited by dimethylnitrosamine (DMN)-induced rats hepatic fibrosis (HF)." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/92123031747987794577.

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碩士<br>國立高雄海洋科技大學<br>水產食品科學研究所<br>101<br>Abstract Curcumin (CUR) is the most active component of turmeric. Numerous studies have demonstrated the ability of CUR is a potent antioxidant and anti-inflammatory agent. Tetrahydrocurcumin (THC) is one of the major metabolites of curcumin, and exhibits many of the same physiological and pharmacological activities as curcumin and, in some systems, may exert greater antioxidant activity than curcumin. However, the mechanisms of THC in inhibited hepatic fibrosis (HF) remain unknown. This study explored mechanisms and effective of the THC inhibited by DMN
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CHEN, JIN-WUN, and 陳錦雯. "Anti-nonalcoholic Fatty Liver Disease (NAFLD) Efficacy of Tetrahydrocurcumin (THC) and Its Molecular Mechanisms of Action." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/80791001880024928697.

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碩士<br>國立高雄海洋科技大學<br>水產食品科學研究所<br>105<br>Tetrahydrocurcumin (THC) is one of the major active colorless metabolites of curcumin. THC exhibited beneficial effects in metabolic syndromes such as diabetic mellitus and dyslipidemia. In vitro study, we investigated the effect of THC on oleic acid (OA)–induced hepatic lipogenesis in hepatocarcinoma cells (HepG2 cells). To investigate the effects of THC in vivo, high fat diet (HFD) fed C57BL/6J mice were orally administered THC (20 or 100 mg/kg body weight) or vehicle for 10 weeks. The cell viability and lipid accumulation was analyzed by trypan blue a
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大澤, 俊彦, 浩二 内田 та 文彦 堀尾. "糖尿病合併症における酸化ストレスの関与と食品因子による予防のメカニズムの解析". 2001. http://hdl.handle.net/2237/13097.

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Book chapters on the topic "Tetrahydrocurcumin"

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Kakkar, Vandita, Komal Saini, Megha Saini, Manoj Kumar, Priyanka Narula, and Ishaan Duggal. "Comparison of Therapeutic Efficacy of Nanoformulations of Curcumin vs Tetrahydrocurcumin in Various Disorders." In Nanoformulations in Human Health. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-41858-8_17.

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Murugan, P. "The Molecular Mechanism Tetrahydrocurcumin as an Antihyperlipidemic Agent." In Advanced Concepts in Medicine and Medical Research Vol. 12. B P International, 2024. http://dx.doi.org/10.9734/bpi/acmmr/v12/8503a.

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Lai, Ching-Shu, and Anwar Choirul. "Mechanism of the Anti-cancer Action of Natural Dietary Compounds." In Dietary Supplements with Antioxidant Activity. The Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/bk9781839166112-00182.

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Cancer is a complicated disease with many puzzles of tumorigenesis remaining unsolved; however, there is strong evidence regarding the link between oxidative stress and cancer. The malignant transformation of cells requires the integration of many factors, and reactive oxygen species (ROS) are dynamically implicated in each step of tumorigenesis. Moreover, ROS are involved in tumorigenesis not only within cancer cells, but also in the interplay between malignant and nonmalignant cells. Therefore, targeting oxidative stress could be a potential strategy for the prevention and treatment of human
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Conference papers on the topic "Tetrahydrocurcumin"

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Wiwattanapatapee, R., S. Setthacheewakul, W. Ketjinda, and K. Mäder. "Novel self-emulsifying controlled release tetrahydrocurcumin pellets coated with an aqueous-based system." In GA 2017 – Book of Abstracts. Georg Thieme Verlag KG, 2017. http://dx.doi.org/10.1055/s-0037-1608376.

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Reports on the topic "Tetrahydrocurcumin"

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แอกทอง, สิทธิพร, та วิไล ชินธเนศ. ผลของ curcumin และ tetrahydrocurcumin ต่อการงอกใหม่ของเส้นประสาทหลังการบาดเจ็บ : รายงานการวิจัย. จุฬาลงกรณ์มหาวิทยาลัย, 2011. https://doi.org/10.58837/chula.res.2011.22.

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การบาดเจ็บของเส้นประสาทส่วนปลายทำให้เกิดการเสื่อมสลายของ axon และการสูญเสียเซลล์ประสาทในปมประสาทไขสันหลัง curcumin เป็นสารที่พบในขมิ้นที่เตรียมจากรากของขมิ้นชันและมีคุณสมบัติที่ปกป้องเซลล์ประสาทในโรคต่าง ๆ ทางระบบประสาทรวมทั้งการบาดเจ็บของเส้นประสาท การศึกษานี้มีจุดประสงค์เพื่อหาขนาดที่เหมาะสมและผลของ curcumin ต่อการสูญเสียเซลล์ประสาทรวมทั้งระยะการงอกใหม่ของเส้นประสาท หนูที่ได้รับการผ่าตัดหนีบเส้นประสาทได้รับ curcumin (100ม 300 and 500 mg/kg/วัน) หรือ vehicle โดยการฉีดเข้าช่องท้องวันละครั้งเป็นเวลา 2 สัปดาห์ ก่อนสิ้นสุดการทดลองประเมินการคืนหน้าที่ของประสาทสั่งการโดยการคำนวณ sciatic functional
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