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Journal articles on the topic 'Tetrahydrocurcumin'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

González, Yisett, Randy Mojica-Flores, Dilan Moreno-Labrador, et al. "Tetrahydrocurcumin Derivatives Enhanced the Anti-Inflammatory Activity of Curcumin: Synthesis, Biological Evaluation, and Structure–Activity Relationship Analysis." Molecules 28, no. 23 (2023): 7787. http://dx.doi.org/10.3390/molecules28237787.

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Tetrahydrocurcumin, the most abundant curcumin transformation product in biological systems, can potentially be a new alternative therapeutic agent with improved anti-inflammatory activity and higher bioavailability than curcumin. In this article, we describe the synthesis and evaluation of the anti-inflammatory activities of tetrahydrocurcumin derivatives. Eleven tetrahydrocurcumin derivatives were synthesized via Steglich esterification on both sides of the phenolic rings of tetrahydrocurcumin with the aim of improving the anti-inflammatory activity of this compound. We showed that tetrahydr

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2

Lai, Ching-Shu, Chi-Tang Ho, and Min-Hsiung Pan. "The Cancer Chemopreventive and Therapeutic Potential of Tetrahydrocurcumin." Biomolecules 10, no. 6 (2020): 831. http://dx.doi.org/10.3390/biom10060831.

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In recent decades, cancer has been one of the leading causes of death worldwide. Despite advances in understanding the molecular basis of tumorigenesis, diagnosis, and clinical therapies, the discovery and development of effective drugs is an active and vital field in cancer research. Tetrahydrocurcumin is a major curcuminoid metabolite of curcumin, naturally occurring in turmeric. The interest in tetrahydrocurcumin research is increasing because it is superior to curcumin in its solubility in water, chemical stability, bioavailability, and anti-oxidative activity. Many in vitro and in vivo st

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3

Rege, Sameera A., Megha A. Varshneya, and Shamim A. Momin. "A Mini-Review: Comparison between curcumin and tetrahydrocurcumin based on their activities." Croatian journal of food science and technology 13, no. 1 (2021): 128–32. http://dx.doi.org/10.17508/cjfst.2021.13.1.16.

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Curcumin, a natural ingredient present in turmeric rhizome is known for its various therapeutic activities such as antioxidant, anti-inflammatory, anticancer, antidiabetic, NF-kB activation suppresser. The hydrogenated derivative of curcumin, i.e., tetrahydrocurcumin, is also found to reveal the same activities. Moreover, the pro-oxidant effect of curcumin is reported, whereas tetrahydrocurcumin does not show any pro-oxidant effects. This contrasting behaviour of the two is attributed to their structures, because conjugation is involved only in curcumin, not in the tetrahydrocurcumin. It can b

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4

Fai, Tan Kin, Goh Hui Yee, Palanirajan Vijayaraj Kumar та Manogaran Elumalai. "Preparation of Chitosan Particles as a Delivery System for Tetrahydrocurcumin: β-cyclodextrin Inclusive Compound for Colorectal Carcinoma". Current Drug Therapy 16, № 5 (2021): 430–38. http://dx.doi.org/10.2174/1574885516666211210153741.

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Background: Tetrahydrocurcumin is a hydrogenated active metabolite of curcumin that exhibits similar pharmacological effects to curcumin. However, its hydrophobic nature has limited its aqueous solubility and bioavailability. By incorporating the tetrahydrocurcumin into β-cyclodextrin, its physiochemical property can be improved. Objective: To develop a chitosan composite loaded with tetrahydrocurcumin inclusive complex, characterize the developed composites, and evaluate its effectiveness on cancer cells. Methods: Tetrahydrocurcumin was formulated into an inclusive complex with β-cyclodextrin

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5

Shimoda, Kei, Naoji Kubota, Yuya Fujitaka та ін. "Production of Tetrahydrocurcumin From Curcumin by Cultured Plant Cells and Inhibitory Effects of Curcuminoids on NF-κB Activity". Natural Product Communications 14, № 9 (2019): 1934578X1987892. http://dx.doi.org/10.1177/1934578x19878920.

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Biotransformation of curcumin was investigated using cultured plant cells of Morus sp. Cultured Morus cells converted curcumin into dihydrocurcumin and tetrahydrocurcumin. The activity of nuclear factor-κB was inhibited by curcumin and tetrahydrocurcumin.

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6

Devaki, Jorapur, Dr Satish Pavuluri, and Savalgi Sonali. "DEVELOPMENT AND VALIDATION OF THE UV-SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF TETRAHYDROCURCUMIN." Tropical Journal of Pharmaceutical and Life Sciences 10, no. 3 (2023): 27–37. https://doi.org/10.61280/tjpls.v10i3.124.

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The main objective is to develop and validate the UV-spectrophotometric method for the estimation of Tetrahydrocurcumin as per ICH guidelines. Materials and Methods: A simple, rapid, accurate, and economical UV-spectrophotometric method has been developed for the estimation of tetrahydrocurcumin. Results: Theλ max of tetrahydrocurcumin was found to be 280nm. The drug follows linearity in the concentration range 2-12 µg mL-1 with a correlation coefficient value of 0.9975. The accuracy of the method was checked by recovery experiment performed at three different levels, i.e., 50%,100% and 120%.

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7

Azeredo, Patrícia dos Santos, Charity Fix, Laena Pernomian, et al. "Tetrahydrocurcumin Outperforms Curcumin in Preventing Oxidative Stress-Induced Dysfunction in Tert-Butyl Hydroperoxide-Stimulated Cardiac Fibroblasts." International Journal of Molecular Sciences 26, no. 13 (2025): 5964. https://doi.org/10.3390/ijms26135964.

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Oxidative stress is a common feature of various pathological conditions, including tissue remodeling and dysfunction. Cardiac fibroblasts, which play a key role in maintaining extracellular matrix homeostasis, are sensitive to oxidative injury. Curcumin and tetrahydrocurcumin are plant-derived polyphenols with antioxidant properties, yet their relative efficacy in preventing oxidative stress–induced dysfunction in cardiac fibroblasts remains unclear. In this study, cardiac fibroblasts were treated with curcumin or tetrahydrocurcumin prior to exposure to tert-butyl hydroperoxide (t-BHP), a wide

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8

Shimoda, Kei, Naoji Kubota, Hirotaka Hirano, Masahiro Matsumoto, Hatsuyuki Hamada, and Hiroki Hamada. "Formation of Tetrahydrocurcumin by Reduction of Curcumin with Cultured Plant Cells of Marchantia Polymorpha." Natural Product Communications 7, no. 4 (2012): 1934578X1200700. http://dx.doi.org/10.1177/1934578x1200700428.

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Cultured plant cells of Marchantia polymorpha, Nicotiana tabacum, Phytolacca americana, Catharanthus roseus, and Gossypium hirsutum were examined for their ability to reduce curcumin. Only M. polymorpha cells converted curcumin into tetrahydrocurcumin in 90% yield in one day. Time-course experiment revealed a two-step formation of tetrahydrocurcumin via dihydrocurcumin.

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9

Boli, Lusia Silfia Pulo, Nufida Dwi Aisyah, Vera Khoirunisa, Heni Rachmawati, Hermawan Kresno Dipojono, and Febdian Rusydi. "Solvent Effect on Bond Dissociation Enthalpy (BDE) of Tetrahydrocurcumin: A Theoretical Study." Materials Science Forum 966 (August 2019): 215–21. http://dx.doi.org/10.4028/www.scientific.net/msf.966.215.

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Solvent effect on bond dissociation enthalpy (BDE) of different functional groups of tetrahydrocurcumin is investigated. This is to evaluate how the polarity of a medium affect BDE and to clarify which functional groups hold the key role in its antioxidant activity through hydrogen transfer. We occupy density functional theory to calculate BDE through geometrical optimization and frequency calculation at six sites of tetrahydrocurcumin in water, methanol and chloroform solvents. The solvents represent polar and non-polar medium. Our result shows that BDE is lower in non-polar medium and hydrog

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10

Lamb, Steven R., and S. Mark Wilkinson. "Contact allergy to tetrahydrocurcumin." Contact Dermatitis 48, no. 4 (2003): 227. http://dx.doi.org/10.1034/j.1600-0536.2003.00062.x.

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11

Duan, Meitao, Ahmed Mahal, Anas Alkouri, et al. "Synthesis, Anticancer Activity, and Molecular Docking of New 1,2,3-Triazole Linked Tetrahydrocurcumin Derivatives." Molecules 29, no. 13 (2024): 3010. http://dx.doi.org/10.3390/molecules29133010.

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Cancer is one of the deadliest diseases to humanity. There is significant progress in treating this disease, but developing some drugs that can fight this disease remains a challenge in the field of medical research. Thirteen new 1,2,3-triazole linked tetrahydrocurcumin derivatives were synthesized by click reaction, including a 1,3-dipolar cycloaddition reaction of tetrahydrocurcumin baring mono-alkyne with azides in good yields, and their in vitro anticancer activity against four cancer cell lines, including human cervical carcinoma (HeLa), human lung adenocarcinoma (A549), human hepatoma ca

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12

Somparn, Nuntiya, Veerapol Kukongviriyapan, Upa Kukongviriyapan, Laddawan Senggunprai, and Auemduan Prawan. "Tetrahydrocurcumin protection against doxorubicin-induced apoptosis." ScienceAsia 41, no. 2 (2015): 114. http://dx.doi.org/10.2306/scienceasia1513-1874.2015.41.114.

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13

Sneharani, A. H., Sridevi Annapurna Singh, P. Srinivas, and A. G. Appu Rao. "Inhibition of lipoxygenase-1 by tetrahydrocurcumin." European Food Research and Technology 233, no. 4 (2011): 561–68. http://dx.doi.org/10.1007/s00217-011-1541-6.

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14

Plyduang, Thipapun, Luelak Lomlim, Supreeya Yuenyongsawad, and Ruedeekorn Wiwattanapatapee. "Carboxymethylcellulose–tetrahydrocurcumin conjugates for colon-specific delivery of a novel anti-cancer agent, 4-amino tetrahydrocurcumin." European Journal of Pharmaceutics and Biopharmaceutics 88, no. 2 (2014): 351–60. http://dx.doi.org/10.1016/j.ejpb.2014.05.011.

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15

Wu, Jia-Ching, Mei-Ling Tsai, Ching-Shu Lai, Ying-Jan Wang, Chi-Tang Ho, and Min-Hsiung Pan. "Chemopreventative effects of tetrahydrocurcumin on human diseases." Food Funct. 5, no. 1 (2014): 12–17. http://dx.doi.org/10.1039/c3fo60370a.

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16

Josifovska, Slavica, Sasho Panov, Nikola Hadzi-Petrushev, et al. "Positive Tetrahydrocurcumin-Associated Brain-Related Metabolomic Implications." Molecules 28, no. 9 (2023): 3734. http://dx.doi.org/10.3390/molecules28093734.

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Tetrahydrocurcumin (THC) is a metabolite of curcumin (CUR). It shares many of CUR’s beneficial biological activities in addition to being more water-soluble, chemically stable, and bioavailable compared to CUR. However, its mechanisms of action have not been fully elucidated. This paper addresses the preventive role of THC on various brain dysfunctions as well as its effects on brain redox processes, traumatic brain injury, ischemia-reperfusion injury, Alzheimer’s disease, and Parkinson’s disease in various animal or cell culture models. In addition to its strong antioxidant properties, the ef

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17

Zhang, Jia, Shalesh Gangwar, Nagmi Bano, Shaban Ahmad, Mohammed S. Alqahtani, and Khalid Raza. "Probing the role of Coniferin and Tetrahydrocurcumin from Traditional Chinese medicine against PSAT1 in early-stage ovarian cancer: An in silico study." PLOS ONE 20, no. 2 (2025): e0313585. https://doi.org/10.1371/journal.pone.0313585.

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Ovarian cancer, a formidable gynaecological malignancy, poses a significant global health challenge, and it is characterised by late-stage diagnosis and a high mortality rate. Even in its early stages, when treatment choices are scarce, ovarian cancer is still a complicated cancer to treat. In this work, we used computational approaches to find putative Traditional Chinese Medicine (TCM) inhibitors that target Phosphoserine Aminotransferase 1 (PSAT1), a crucial enzyme linked to the development of early-stage ovarian cancer. Using a methodical screening approach, we chose a panel of TCM compoun

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18

Mishra, Shilpa, Mamata Mishra, Pankaj Seth та Shiv Kumar Sharma. "Tetrahydrocurcumin confers protection against amyloid β-induced toxicity". NeuroReport 22, № 1 (2011): 23–27. http://dx.doi.org/10.1097/wnr.0b013e328341e141.

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19

Park, C. S., H. J. Jang, J. H. Lee, M. Y. Oh, and H. J. Kim. "Tetrahydrocurcumin Ameliorates Tacrolimus-Induced Nephrotoxicity Via Inhibiting Apoptosis." Transplantation Proceedings 50, no. 9 (2018): 2854–59. http://dx.doi.org/10.1016/j.transproceed.2018.03.031.

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20

Mahal, Ahmed, Ping Wu, Zi-Hua Jiang, and Xiaoyi Wei. "Schiff Bases of Tetrahydrocurcumin as Potential Anticancer Agents." ChemistrySelect 4, no. 1 (2019): 366–69. http://dx.doi.org/10.1002/slct.201803159.

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21

Chen, Ke-Yu, Shuang Luo, Yun-Teng Liu, Xue Wang, and Jian-Bo Wang. "Progress of research on tetrahydrocurcumin against liver injury." Gastroenterology and Hepatology Research 5, no. 3 (2023): 14. http://dx.doi.org/10.53388/ghr2023-03-078.

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22

Chiou Chyi, Lim, Tan Kin Fai, Shiau-Chuen Cheah, and Palanirajan Vijayaraj Kumar. "Development of Gold-Alloy Nanocomposite for Tetrahydrocurcumin Delivery." Current Trends in Biotechnology and Pharmacy 17, no. 4A (2023): 70–80. http://dx.doi.org/10.5530/ctbp.2023.4s.92.

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23

Kao, Yu-Wen, Sheng-Kai Hsu, Jeff Yi-Fu Chen, et al. "Curcumin Metabolite Tetrahydrocurcumin in the Treatment of Eye Diseases." International Journal of Molecular Sciences 22, no. 1 (2020): 212. http://dx.doi.org/10.3390/ijms22010212.

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Curcumin is one of the most valuable natural products due to its pharmacological activities. However, the low bioavailability of curcumin has long been a problem for its medicinal use. Large studies have been conducted to improve the use of curcumin; among these studies, curcumin metabolites have become a relatively new research focus over the past few years. Additionally, accumulating evidence suggests that curcumin or curcuminoid metabolites have similar or better biological activity than the precursor of curcumin. Recent studies focus on the protective role of plasma tetrahydrocurcumin (THC

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24

Pari, L. "Protective role of tetrahydrocurcumin against erythromycin estolate-induced hepatotoxicity." Pharmacological Research 49, no. 5 (2004): 481–86. http://dx.doi.org/10.1016/j.phrs.2003.11.005.

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25

Habibur Rahman, Shiek Abdul Kadhar Mohamed Ebrahim, Telny Thomas Chungath, Hariprasad Ranganathan, et al. "Development and Pharmacokinetic Assessment of Tetrahydrocurcumin Solid Lipid Nanoparticles." Acta Pharmaceutica Hungarica 91, no. 3-4 (2021): 304–5. http://dx.doi.org/10.33892/aph.2021.91.304-305.

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26

Majeed, Muhammed, Sankaran Natarajan, Anjali Pandey, Sarang Bani, and Lakshmi Mundkur. "Subchronic and Reproductive/Developmental Toxicity Studies of Tetrahydrocurcumin in Rats." Toxicological Research 35, no. 1 (2019): 65–74. http://dx.doi.org/10.5487/tr.2019.35.1.065.

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27

Pari, Leelavinothan, and Pidaran Murugan. "Tetrahydrocurcumin Prevents Brain Lipid Peroxidation in Streptozotocin-Induced Diabetic Rats." Journal of Medicinal Food 10, no. 2 (2007): 323–29. http://dx.doi.org/10.1089/jmf.2006.058.

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28

Ajavakom, Vachiraporn, Thatsawan Yutthaseri, and Anawat Ajavakom. "Natural Tetrahydrocurcumin in Multi-Component Synthesis of 1,4-Dihydropyridine Derivatives." HETEROCYCLES 92, no. 8 (2016): 1512. http://dx.doi.org/10.3987/com-16-13500.

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29

Pari, Leelavinothan, and Pidaran Murugan. "Tetrahydrocurcumin: Effect on Chloroquine-Mediated Oxidative Damage in Rat Kidney." Basic Clinical Pharmacology Toxicology 99, no. 5 (2006): 329–34. http://dx.doi.org/10.1111/j.1742-7843.2006.pto_503.x.

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30

Murugan, Pidaran, and Leelavinothan Pari. "Antioxidant effect of tetrahydrocurcumin in streptozotocin–nicotinamide induced diabetic rats." Life Sciences 79, no. 18 (2006): 1720–28. http://dx.doi.org/10.1016/j.lfs.2006.06.001.

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31

Zhang, Xingzhen, Lei Peng, Anchang Liu, Jianbo Ji, Lixia Zhao, and Guangxi Zhai. "The enhanced effect of tetrahydrocurcumin on radiosensitivity of glioma cells." Journal of Pharmacy and Pharmacology 70, no. 6 (2018): 749–59. http://dx.doi.org/10.1111/jphp.12891.

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32

Vacek, Jonathan C., Jyotirmaya Behera, Akash K. George, Pradip K. Kamat, Anuradha Kalani, and Neetu Tyagi. "Tetrahydrocurcumin ameliorates homocysteine-mediated mitochondrial remodeling in brain endothelial cells." Journal of Cellular Physiology 233, no. 4 (2017): 3080–92. http://dx.doi.org/10.1002/jcp.26145.

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33

Zeng, Anqi, Yunyun Quan, Hongxia Tao, Ying Dai, Linjiang Song, and Junning Zhao. "The Role of Tetrahydrocurcumin in Tumor and Neurodegenerative Diseases Through Anti-Inflammatory Effects." International Journal of Molecular Sciences 26, no. 8 (2025): 3561. https://doi.org/10.3390/ijms26083561.

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Tetrahydrocurcumin (THC), a curcumin derivative, shows potential in oncology and neurology. It regulates NF-κB, reduces inflammation, promotes cancer cell apoptosis, inhibits tumor angiogenesis, and enhances antioxidants, aiding in treating inflammation-related cancers. In neurology, THC’s anti-inflammatory and antioxidant properties protect neurons, reduce neuroinflammation, and support autophagy for cellular debris clearance, with its blood–brain barrier penetration offering a neuroprotective edge. Research on THC’s therapeutic application must focus on improving delivery and bioavailability

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34

Astuti, Ika Yuni, Ani Yupitawati, and Nunuk Aries Nurulita. "Anti-aging activity of tetrahydrocurcumin, Centella asiatica extract, and its mixture." Advances in Traditional Medicine 21, no. 1 (2021): 57–63. http://dx.doi.org/10.1007/s13596-020-00532-9.

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35

Pendleton, Emily G., Roudabeh J. Jamasbi, and Michael E. Geusz. "Tetrahydrocurcumin, Curcumin, and 5-Fluorouracil Effects on Human Esophageal Carcinoma Cells." Anti-Cancer Agents in Medicinal Chemistry 19, no. 8 (2019): 1012–20. http://dx.doi.org/10.2174/1871520619666190116141448.

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Background: Esophageal cancer responds poorly to traditional therapies, and novel treatments are needed. The phytochemical curcumin is a potential treatment for Esophageal Squamous Cell Carcinoma (ESCC). A curcumin metabolite, tetrahydrocurcumin (THCUR), has anti-cancer effects and greater bioavailability than curcumin. Objective: Evaluate THCUR as an anti-cancer agent relative to curcumin and a standard cancer drug, 5-fluorouracil (5-FU), along with treatment interactions. Materials and Methods: Assay cell proliferation and viability following individual and combined delivery of the compounds

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36

Andonegi, Mireia, Teresa Carranza, Alaitz Etxabide, Koro de la Caba, and Pedro Guerrero. "3D-Printed Mucoadhesive Collagen Scaffolds as a Local Tetrahydrocurcumin Delivery System." Pharmaceutics 13, no. 10 (2021): 1697. http://dx.doi.org/10.3390/pharmaceutics13101697.

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Native collagen doughs were processed using a syringe-based extrusion 3D printer to obtain collagen scaffolds. Before processing, the rheological properties of the doughs were analyzed to determine the optimal 3D printing conditions. Samples showed a high shear-thinning behavior, reported beneficial in the 3D printing process. In addition, tetrahydrocurcumin (THC) was incorporated into the dough formulation and its effect on collagen structure, as well as the resulting scaffold’s suitability for wound healing applications, were assessed. The denaturation peak observed by differential scanning

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37

Masri, Masneli, Deni Rahmat, and Agung Eru Wibowo. "Pengembangan Sediaan Emulgel dari Nanostructured Lipid Carrier (NLC) Tetrahydrocurcumin Sebagai Pencerah." Jurnal Sains dan Kesehatan 3, no. 3 (2021): 478–87. http://dx.doi.org/10.25026/jsk.v3i3.580.

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Kosmetik digunakan untuk berbagai tujuan misalnya untuk membuat penampilan menarik. Dari sekian banyak jenis kosmetik yang digunakan, krim pencerah kulit banyak diminati terutama oleh para wanita di Asia, termasuk Indonesia, agar diperoleh tampilan kulit wajah yang putih dan bersih. Tujuan dari penelitian ini adalah untuk mengembangkan formulasi sediaan emulgel pencerah kulit yang mengandung THC-NLC untuk penggunaan topikal. THC-NLC dibuat dengan menggunakan metode emulsifikasi dengan menggunaan campuran antara PEG-8 beexwax (Apifil) sebagai lemak padat, Grapeseed Oil sebagai lemak cair, plant

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38

Murugan, Pidaran, and Leelavinothan Pari. "EFFECT OF TETRAHYDROCURCUMIN ON ERYTHROMYCIN ESTOLATE-INDUCED LIPID PEROXIDATION IN RATS." Journal of Basic and Clinical Physiology and Pharmacology 16, no. 1 (2005): 1–16. http://dx.doi.org/10.1515/jbcpp.2005.16.1.1.

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39

Sriraksa, S., N. Sermkaew, S. Setthacheewakul, and R. Wiwattanapatapee. "Floating Alginate Beads as Carriers for Self-Emulsifying System Containing Tetrahydrocurcumin." Advanced Materials Research 506 (April 2012): 517–20. http://dx.doi.org/10.4028/www.scientific.net/amr.506.517.

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Tetrahydrocurcumin (THC), one of the curcumin metabolites, exhibits pharmacological activities such as antioxidant, anti-inflammatory and anti-carcinogenic properties. However, the pharmacological effect of THC is limited due to its low aqueous solubility. Floating alginate beads containing self-emulsifying drug delivery system (SEDDS) of THC were developed to increase drug solubility and prolong gastric residence time. Use of different weight proportions of sodium alginate (Na-alg.), calcium chloride (CaCl2) and water soluble pore former (Polyvinylalcohol-polyethylene glycol copolymer; Kollic

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40

Lin, Zhenyu, Jun Li, and Qingrong Huang. "Characterizations on a GRAS Electrospun Lipid–Polymer Composite Loaded with Tetrahydrocurcumin." Foods 13, no. 11 (2024): 1672. http://dx.doi.org/10.3390/foods13111672.

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Electrospun/sprayed fiber films and nanoparticles were broadly studied as encapsulation techniques for bioactive compounds. Nevertheless, many of them involved using non-volatile toxic solvents or non-biodegradable polymers that were not suitable for oral consumption, thus rather limiting their application. In this research, a novel electrospun lipid–polymer composite (ELPC) was fabricated with whole generally recognized as safe (GRAS) materials including gelatin, medium chain triglyceride (MCT) and lecithin. A water-insoluble bioactive compound, tetrahydrocurcumin (TC), was encapsulated in th

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41

Dewi, Firli Rahmah Primula, Verah Elfianah, Adyn Haura Mahira та ін. "Improving the anticancer efficacy of tetrahydrocurcumin via β-cyclodextrin inclusion complexation". Journal of Pharmacy & Pharmacognosy Research 13, № 3 (2025): 968–78. https://doi.org/10.56499/jppres24.2153_13.3.968.

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Context: Tetrahydrocurcumin (THC) exhibits superior biological and pharmacological characteristics compared to curcumin, demonstrating efficacy in suppressing tumor metastasis and angiogenesis and acting as a potent preventive agent against carcinogenesis. However, its limited water solubility restricts its application in aqueous formulations. Aims: To evaluate the efficacy of a β-cyclodextrin (β-CD)-THC inclusion complex in combating colon and liver cancer in animal models. Female rats (n=24) were divided into six groups and induced with colon and liver cancer using 1,2-dimethylhydrazine (DMH

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42

Mondal, Nandan K., Jyotirmaya Behera, Kimberly E. Kelly, Akash K. George, Pranav K. Tyagi, and Neetu Tyagi. "Tetrahydrocurcumin epigenetically mitigates mitochondrial dysfunction in brain vasculature during ischemic stroke." Neurochemistry International 122 (January 2019): 120–38. http://dx.doi.org/10.1016/j.neuint.2018.11.015.

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43

Kim, S. S., H. J. Jang, M. Y. Oh, J. H. Lee, and K. S. Kang. "Tetrahydrocurcumin Enhances Islet Cell Function and Attenuates Apoptosis in Mouse Islets." Transplantation Proceedings 50, no. 9 (2018): 2847–53. http://dx.doi.org/10.1016/j.transproceed.2018.03.033.

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44

HEATH, D., M. PRUITT, D. BRENNER, A. BEGUM, S. FRAUTSCHY, and C. ROCK. "Tetrahydrocurcumin in plasma and urine: Quantitation by high performance liquid chromatography." Journal of Chromatography B 824, no. 1-2 (2005): 206–12. http://dx.doi.org/10.1016/j.jchromb.2005.07.026.

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45

Boli, Lusia S. P., Vera Khoirunisa, Adhitya G. Saputro, et al. "Frontier Orbitals of Dehydrogenated Tetrahydrocurcumin in Water Solvent: A Theoretical Study." Journal of Physics: Conference Series 1090 (September 2018): 012029. http://dx.doi.org/10.1088/1742-6596/1090/1/012029.

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46

Boli, Lusia S. P., Vera Khoirunisa, Adhitya G. Saputro, et al. "Theoretical study on frontier orbitals of dehydrogenated tetrahydrocurcumin in gas phase." Journal of Physics: Conference Series 1204 (April 2019): 012019. http://dx.doi.org/10.1088/1742-6596/1204/1/012019.

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47

Mahal, Ahmed, Ping Wu, Zi-Hua Jiang, and Xiaoyi Wei. "Synthesis and Cytotoxic Activity of Novel Tetrahydrocurcumin Derivatives Bearing Pyrazole Moiety." Natural Products and Bioprospecting 7, no. 6 (2017): 461–69. http://dx.doi.org/10.1007/s13659-017-0143-9.

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Murugan, Pidaran. "A Review on Antidiabetic Effect of Tetrahydrocurcumin in Type 2 Diabetes." Journal of Advanced Zoology 44, S7 (2023): 147–56. http://dx.doi.org/10.17762/jaz.v44is7.2747.

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Diabetes mellitus is possibly the world’s largest growing metabolic disease and as the knowledge on the heterogeneity of this disorder is advanced, the need for more appropriate therapy increases. Currently available drug regimes for management of diabetes mellitus have certain drawbacks and, therefore, there is a need for safer and more effective antidiabetic drugs. Natural products from medicinal plants continue to form a common platform for the discovery of new chemical entities in the modern drug discovery programmes. The belief that natural medicines are much safer than synthetic drugs ha

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Weerawatanakorn, Monthana, Shu-Chen Hsieh, Mei-Ling Tsai, et al. "Inhibitory effect of tetrahydrocurcumin on dimethylnitrosamine-induced liver fibrosis in rats." Journal of Functional Foods 7 (March 2014): 305–13. http://dx.doi.org/10.1016/j.jff.2014.01.030.

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Giang Thi Phuong, Ly, Chuyen Phan Thi, Mai Tran Thi Nhu, and Huy Nguyen Quang. "Synthesis, characterization and evaluation catalytic ability of nano Pt / biochar for curcumin conversion." Vietnam Journal of Catalysis and Adsorption 9, no. 1 (2020): 15–19. http://dx.doi.org/10.51316/jca.2020.003.

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Biochar and Pt/biochar were successfully synthesized. This catalysts were characterized by TPD-N2, EDX, SEM and TEM techniques. The results of adsorption-desorption nitrogen showed a decrease in average volume and capillary diameter, indicating the presence of Pt nano dispersed in the medium capillary. TEM image for the size of Pt nanoparticles were 3-4nm. Investigate catalytic potential for curcumin conversion in methanol and ethanol, after 6 hours with Pt/biochar, the corresponding efficiency were 57.87% and 40.61% respectively. The presence of a new peak at a wavelength range is likely to b

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