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Journal articles on the topic 'Tetrahydropyrrolo[3'

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Published: 9 March 2023

Last updated: 31 July 2025

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1

Konopíková, Marta, Lubor Fišera, and Naďa Prónayová. "Synthesis and Fungicidal Activity of Isoxazolines Fused to 3,5-Dichloromaleimide." Collection of Czechoslovak Chemical Communications 57, no. 7 (1992): 1521–36. http://dx.doi.org/10.1135/cccc19921521.

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3-Phenyl-5-(3,5-dichlorophenyl)-3a,4,6,6a-tetrahydropyrrolo[3,4-d]isoxazoles (III, R = H) and 3-phenyl-5-(3,5-dichlorophenyl)-6a-methyl-3a,4,6,6a-tetrahydropyrrolo[3,4-d]isoxazoles (IV, R = CH3) were prepared by 1,3-dipolar cycloaddition of substituted benzonitrile oxides I to N-(3,5-dichlorophenyl)maleimide (I, R = H), or its methyl derivative II (R = CH3). Cycloaddition to compound II (R = CH3) proceeded regiospecifically. Reduction of IVg with NaBH4 was regio- and stereoselective to yield the hydroxylactams VIIg, VIIIg, and IXg. Antifungal activity of several products was worse than that of

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2

Yuan, Chunhao, Leijie Zhou, Zhanhu Sun, and Hongchao Guo. "Phosphine-catalyzed [3 + 2] cycloaddition of phthalazinium dicyanomethanides with allenoates: highly efficient synthesis of 1,2,3,10b-tetrahydropyrrolo[2,1-a]phthalazine derivatives." RSC Advances 6, no. 81 (2016): 77931–36. http://dx.doi.org/10.1039/c6ra13643e.

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The phosphine-catalyzed [3 + 2] cycloaddition has been achieved at room temperature, providing novel heterocyclic compounds, 1,2,3,10b-tetrahydropyrrolo[2,1-a]phthalazine derivatives, as single (Z)-isomers in excellent yields (88–99% yield).

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3

Wang, Bing-Tao, Hua-Dong Yue, Shu-Ping Luo, Li-Ping Wang, and Dan-Qian Xu. "Diphenyl-5,6,7,7a-tetrahydropyrrolo[1,2-c]oxazol-3(1H)-one." Acta Crystallographica Section E Structure Reports Online 63, no. 3 (2007): o1108—o1109. http://dx.doi.org/10.1107/s1600536807004394.

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The title compound, C18H17NO2, synthesized from enantiomerically pure L-proline, methyl chloroformate and a Grignard reagent, crystallizes with two molecules in the asymmetric unit. A chair conformation is adopted by the two fused five-membered rings.

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4

Barker, David, Lisa Pilkington, Natalie Haverkate, Michelle van Rensburg, Johannes Reynisson, and Euphemia Leung. "Synthesis of 3-Amino-2-carboxamide Tetrahydropyrrolo[2,3-b]quinolines." Synlett 27, no. 20 (2016): 2811–14. http://dx.doi.org/10.1055/s-0036-1588619.

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5

Volovenko, Yulian M., Elizaveta V. Resnyanska, and Anton V. Tverdokhlebov. "A Facile Route to the 6-Hetaryl Substituted Pyrrolo[1,2-a]thieno[3,2-e]pyrimidine Derivatives." Collection of Czechoslovak Chemical Communications 67, no. 3 (2002): 365–72. http://dx.doi.org/10.1135/cccc20020365.

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Hitherto unknown 6-hetaryl-4,5,7,8-tetrahydropyrrolo[1,2-a]thieno[3,2-e]pyrimidine-4,7-diones (7a-7g) were prepared by reaction of ethyl 2-aminothiophene-3-carboxylates 5 with 4-chloro-2-hetaryl-3-oxobutanonitriles 4 in DMF at 100 °C. When the same reagents were treated in the presence of triethylamine, a dependence of the reaction pathway on the nature of the hetaryl substituent in chloronitrile component was observed. This was explained in terms of steric factors.

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6

Musgrave, RP, NW Jacobsen, G. Bourne, CHL Kennard, G. Smith, and TCW Mak. "Cycloaddition Reactions of 3-Dimethylamino-1-methyl-1,2,4-triazinium-5-olates With Dimethyl Acetylenedicarboxylate." Australian Journal of Chemistry 48, no. 6 (1995): 1175. http://dx.doi.org/10.1071/ch9951175.

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The cycloaddition reactions of some 3-dimethylamino-1-methyl-1,2,4-triazinium-5-olates (1) with dimethyl acetylenedicarboxylate ( dmad ) were studied. The products in all cases were found tobe dimethyl 4-dimethylamino-1-methyl-6-oxo-1,3a,6,6a-tetrahydropyrrolo[3,4-c]pyrazole-3,3a-dicarboxylate derivatives (2). The structure determinations were carried out by 1H and 13C n.m.r. and mass spectrometry, and for one derivative by single-crystal X-ray diffractometry. The mechanism of the reaction is also discussed.

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7

Elmuradov, Burkhon Zh, Charoskhon E. Makhmadiyarova, Kambarali K. Turgunov, Bakhodir Tashkhodjaev, and Khusnutdin M. Shakhidoyatov. "(4-Nitrophenyl)(1,2,3,9-tetrahydropyrrolo[2,1-b]quinazolin-3-yl)methanol monohydrate." Acta Crystallographica Section E Structure Reports Online 67, no. 7 (2011): o1680. http://dx.doi.org/10.1107/s1600536811021775.

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8

Barnes, J. C., J. N. Low, J. D. Paton, A. D. Dunn та K. I. Kinnear. "(Z)-3-(α-Hydroxybenzylidene)-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazolin-9-one, C18H14N2O2". Acta Crystallographica Section C Crystal Structure Communications 41, № 2 (1985): 282–84. http://dx.doi.org/10.1107/s0108270185003638.

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9

Omelian, Taras V., Alexey V. Dobrydnev, Oleksandr Yu Utchenko, Eugeniy N. Ostapchuk, Irina S. Konovalova, and Yulian M. Volovenko. "The reactivity of tetrahydropyrrolo[1,2-b]isothiazol-3(2H)-one 1,1-dioxides." Monatshefte für Chemie - Chemical Monthly 151, no. 11 (2020): 1759–72. http://dx.doi.org/10.1007/s00706-020-02694-3.

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10

Bremner, JB, BM Eschler, BW Skelton, and AH White. "Photolysis of Vinylogous Chloroacetamides as a Route to Novel Bridged Heterocycles." Australian Journal of Chemistry 47, no. 10 (1994): 1935. http://dx.doi.org/10.1071/ch9941935.

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Photolysis of 1-( chloroacetyl )-8,9-dimethoxy-2,3,5,6-tetrahydropyrrolo[2,1-a] isoquinoline (4a) and 1-( chloroacetyl )-9,10-dimethoxy-3,4,6,7-tetrahydro-2H-benzo[a] quinolizine (4b) in acidified water/ acetonitrile each gave mixtures of two products: 10,11-dimethoxy-1,4,5,6,7,8-hexahydro-3,6-methano-2H-3-benzazecine-7,13-dione (5) plus crude 7,8-dimethoxy-1,2,4,5,9,10-hexahydrobenzo [de] pyrrolo [3,2,1-ij] isoquinoline-9,10-dione (6); and 12-hydroxy-11-methoxy- 1,2,4,5,6,7,8,9-octahydro-3,7-methano-3-benzazacycloundecine-8,14-dione (7) and 8,9-dimethoxy-2,3,5,6,10,11-hexahydro-1H-benzo[de] p

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11

Fang, Ren-Jie, Chen Yan, Jing Sun, Ying Han, and Chao-Guo Yan. "Efficient synthesis of polyfunctionalized carbazoles and pyrrolo[3,4-c]carbazoles via domino Diels–Alder reaction." Beilstein Journal of Organic Chemistry 17 (September 16, 2021): 2425–32. http://dx.doi.org/10.3762/bjoc.17.159.

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The p-TsOH-catalyzed Diels–Alder reaction of 3-(indol-3-yl)maleimides with chalcone in toluene at 60 °C afforded two diastereoisomers of tetrahydropyrrolo[3,4-c]carbazoles, which can be dehydrogenated by DDQ oxidation in acetonitrile at room temperature to give the aromatized pyrrolo[3,4-c]carbazoles in high yields. On the other hand, the one-pot reaction of 3-(indol-3-yl)-1,3-diphenylpropan-1-ones with chalcones or benzylideneacetone in acetonitrile in the presence of p-TsOH and DDQ resulted in polyfunctionalized carbazoles in satisfactory yields. The reaction mechanism included the DDQ oxida

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12

Bengtsson, Christoffer, and Ylva Gravenfors. "Rapid Construction of a Chloromethyl-Substituted Duocarmycin-like Prodrug." Molecules 28, no. 12 (2023): 4818. http://dx.doi.org/10.3390/molecules28124818.

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The construction of duocarmycin-like compounds is often associated with lengthy synthetic routes. Presented herein is the development of a short and convenient synthesis of a type of duocarmycin prodrug. The 1,2,3,6-tetrahydropyrrolo[3,2-e]indole-containing core is here constructed from commercially available Boc-5-bromoindole in four steps and 23% overall yield, utilizing a Buchwald–Hartwig amination followed by a sodium hydride-induced regioselective bromination. In addition, protocols for selective mono- and di-halogenations of positions 3 and 4 were also developed, which could be useful fo

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13

Bunce, Richard, and Field Watts. "Synthesis of Aryl-Substituted 3,3a,4,5-Tetrahydropyrrolo[1,2-a] quinolin-1(2H)-ones and 2,3,4,4a,5,6-Hexahydro-1H-pyrido[1,2-a]quinolin-1-ones." Synthesis 51, no. 02 (2018): 564–72. http://dx.doi.org/10.1055/s-0037-1609940.

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A new route to the title benzo-fused angular tricyclic amides 3,3a,4,5-tetrahydropyrrolo- and 2,3,4,4a,5,6-hexahydro-1H-pyrido[1,2-a]quinolin-1-ones is reported from 1-(tert-butyl) 6-ethyl 3-oxohexanedioate and 1-(tert-butyl) 7-ethyl 3-oxoheptanedioate. Alkylation of these β-keto diesters with a series of 2-nitrobenzyl bromides followed by acid hydrolysis and decarboxylation gives ethyl 6-(2-nitrophenyl)-4-oxohexanoates and ethyl 7-(2-nitrophenyl)-5-oxoheptanoates, respectively. Reductive amination under hydrogenation conditions followed by ester hydrolysis and condensative ring closure afford

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14

Yavari, Issa, Anvar Mirzaei, Loghman Moradi, and Nargess Hosseini. "Stereoselective synthesis of dialkyl 3-spiroindanedione-1,2,3,3a-tetrahydropyrrolo[1,2-a]quinoline-1,2-dicarboxylates." Tetrahedron Letters 49, no. 15 (2008): 2355–58. http://dx.doi.org/10.1016/j.tetlet.2008.02.075.

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15

Bai, Xiao-Guang, Ju-Xian Wang, and Yu-Cheng Wang. "N-(1-Acetyl-5-benzoyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)benzamide." Acta Crystallographica Section E Structure Reports Online 68, no. 6 (2012): o1677. http://dx.doi.org/10.1107/s1600536812019708.

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In the molecule of the title compound, C21H18N4O3, the fused pyrrolo[3,4-c]pyrazole ring system is approximately planar [maximum deviation = 0.0486 (16) Å] and forms dihedral angles of 87.21 (8) and 35.46 (7)° with the phenyl rings. In the crystal, N—H...O and C—H...O hydrogen bonds and weak C—H...π interactions link the molecules into chains parallel to [201].

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16

Pevarello, Paolo, Daniele Fancelli, Anna Vulpetti, et al. "3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: A new class of CDK2 inhibitors." Bioorganic & Medicinal Chemistry Letters 16, no. 4 (2006): 1084–90. http://dx.doi.org/10.1016/j.bmcl.2005.10.071.

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17

Volovenko, Yu M., E. V. Resnyanskaya, and A. V. Tverdokhlebov. "ChemInform Abstract: Synthesis of 3-Hetaryl-1,2,4,5-tetrahydropyrrolo[1,2-a]quinazoline-2,5-diones." ChemInform 33, no. 52 (2010): no. http://dx.doi.org/10.1002/chin.200252151.

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18

Do, Thu Trang, Meera Stephen, Khai Leok Chan, Sergei Manzhos, Paul L. Burn, and Prashant Sonar. "Pyrrolo[3,2-b]pyrrole-1,4-dione (IsoDPP) End Capped with Napthalimide or Phthalimide: Novel Small Molecular Acceptors for Organic Solar Cells." Molecules 25, no. 20 (2020): 4700. http://dx.doi.org/10.3390/molecules25204700.

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We introduce two novel solution-processable electron acceptors based on an isomeric core of the much explored diketopyrrolopyrrole (DPP) moiety, namely pyrrolo[3,2-b]pyrrole-1,4-dione (IsoDPP). The newly designed and synthesized compounds, 6,6′-[(1,4-bis{4-decylphenyl}-2,5-dioxo-1,2,4,5-tetrahydropyrrolo[3,2-b]pyrrole-3,6-diyl)bis(thiophene-5,2-diyl)]bis[2-(2-butyloctyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione] (NAI-IsoDPP-NAI) and 5,5′-[(1,4-bis{4-decylphenyl}-2,5-dioxo-1,2,4,5-tetrahydropyrrolo[3,2-b]pyrrole-3,6-diyl)bis(thiophene-5,2-diyl)]bis[2-(2-butyloctyl)isoindoline-1,3-dione] (PI-IsoDP

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19

Xia, Wen-Bin, Xiao-Guang Bai, Hong-Tao Liu, and Ju-Xian Wang. "5-tert-Butyl 1-ethyl 3-amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole-1,5-dicarboxylate." Acta Crystallographica Section E Structure Reports Online 67, no. 5 (2011): o1150. http://dx.doi.org/10.1107/s1600536811013444.

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20

Trávníček, Martin, Jiří Pospíšil, and Milan Potáček. "Reactions of a New Family of Amide Derivatives of Phenanthridinium Azomethine Ylides with Dipolarophiles." Collection of Czechoslovak Chemical Communications 64, no. 12 (1999): 1993–2006. http://dx.doi.org/10.1135/cccc19991993.

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Reaction of a series of N-alkyl- and N,N-dialkylbromoacetamides 1a-1e with phenanthridine afforded quaternary phenanthridinium salts 2a-2e. These compounds treated with triethylamine form azomethine ylides which undergo a cycloaddition reaction with activated C=C bond, giving 3-(N-alkylcarbamoyl)-1,2,3,12b-tetrahydropyrrolo[1,2-f]phenanthridines 3a-3e, 4c, 5c, 6c or 3-(N-alkylcarbamoyl)-2,3-dihydropyrrolo[1,2-f]phenanthridine 7c. Their stereochemistry was studied by NMR spectroscopy. The best results were obtained with fumaronitrile as a dipolarophile. It has been found that the ylides react i

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21

Tojiboev, Akmal, Sherzod Zhurakulov, Valentina Vinogradova, Ulli Englert, and Ruimin Wang. "Stereochemistry of the methylidene-bridged quinazoline-isoquinoline alkaloid 3-{[6,7-dimethoxy-1-(4-nitrophenyl)-1,2,3,4-tetrahydroisoquinolin-2-yl]methylidene}-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazolin-9-one methanol monosolvate." Acta Crystallographica Section E Crystallographic Communications 76, no. 6 (2020): 914–19. http://dx.doi.org/10.1107/s2056989020006696.

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Two potentially bioactive fragments, namely a tricyclic quinazoline derivative with an exocyclic alkene moiety and a substituted isoquinoline, are coupled to give 3-{[6,7-dimethoxy-1-(4-nitrophenyl)-1,2,3,4-tetrahydroisoquinolin-2-yl]methylidene}-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazolin-9-one. The target product crystallizes as a methanol solvate, C29H26N4O5·CH4O, and is E configured. The alternative Z isomer would necessarily imply either considerable twist about the central double bond or very unfavourable intramolecular contacts between sterically more demanding substituents. The main res

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22

Boukouvala, M. C., N. G. Kavallieratos, C. G. Athanassiou, and L. P. Hadjiarapoglou. "Biological activity of two new pyrrole derivatives against stored-product species: influence of temperature and relative humidity." Bulletin of Entomological Research 106, no. 4 (2016): 446–56. http://dx.doi.org/10.1017/s0007485315001108.

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AbstractMembers of the pyrrole group are likely to have interesting properties that merit additional investigation as insecticides at the post-harvest stages of agricultural commodities. In the present work, the insecticidal effect of two new pyrrole derivatives, ethyl 3-(benzylthio)-4,6-dioxo-5-phenyl-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrrole-carboxylate (3i) and isopropyl 3-(benzylthio)-4,6-dioxo-5-phenyl-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrrole-carboxylate (3k) were studied as stored-wheat protectants against two major stored-product insect species, the confused flour beetle, Tribolium confusu

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23

Bai, Xiao-Guang, Dong-Ke Yu, Ju-Xian Wang, et al. "Design, synthesis and anticancer activity of 1-acyl-3-amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole derivatives." Bioorganic & Medicinal Chemistry Letters 22, no. 22 (2012): 6947–51. http://dx.doi.org/10.1016/j.bmcl.2012.08.117.

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24

Imhof, Wolfgang, Helmar Görls, and Kathi Halbauer. "1,4,N-Tri-tert-butyl-2,5-bis-tert-butylimino-1,2,4,5-tetrahydropyrrolo[3,2-b]pyrrol-3-amine." Acta Crystallographica Section E Structure Reports Online 62, no. 12 (2006): o5866—o5868. http://dx.doi.org/10.1107/s1600536806050112.

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25

Khan, Amir Muhammad, Ghulam Abbas, Rizwana Aleem Qureshi, Uzma Khan, Muhammad Asad Ghufran, and Helen Stoeckli-Evans. "3-Hydroxy-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazolin-4-ium chloride dihydrate: (+)-vasicinol hydrochloride dihydrate fromPeganum harmalaL." Acta Crystallographica Section E Structure Reports Online 65, no. 3 (2009): o474—o475. http://dx.doi.org/10.1107/s1600536809003766.

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26

Li, Xun, Shawn Branum, Ronald K. Russell, Weiqin Jiang, and Zhihua Sui. "An Efficient Process for Synthesis of 3-(R)-3-(2,3-Dihydrobenzofuran-5-yl)- 1,2,3,4-tetrahydropyrrolo[3,4-b]quinolin-9-one." Organic Process Research & Development 9, no. 5 (2005): 640–45. http://dx.doi.org/10.1021/op050079y.

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27

Pedras, M. Soledade, and Francis I. Okanga. "Metabolism of analogs of the phytoalexin brassinin by plant pathogenic fungi." Canadian Journal of Chemistry 78, no. 3 (2000): 338–46. http://dx.doi.org/10.1139/v00-024.

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he metabolism of analogs of the cruciferous phytoalexin brassinin by the phytopathogenic fungi Phoma lingam (Tode ex Fr.) "virulent" and "avirulent" groups (sexual stage Leptosphaeria maculans (Desm.) Ces. et de Not.) and Alternaria brassicae (Berk.) Sacc. is reported. It was established that each pathogen detoxified methyl tryptamine dithiocarbamate, although yielding different metabolic products. While the biotransformation by virulent P. lingam proceeded to yield methyl 3a-hydroxy-3,3a,8,8a-tetrahydropyrrolo[2,3-b]indol-1(2H)-yl carbodithioate and indole-3-acetic acid as final products, avi

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28

Trushkov, Igor V., Tatyana A. Nevolina, Vitaly A. Shcherbinin, Lyudmila N. Sorotskaya, and Alexander V. Butin. "Furan ring opening–pyrrole ring closure. A simple route to 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-3-ones." Tetrahedron Letters 54, no. 30 (2013): 3974–76. http://dx.doi.org/10.1016/j.tetlet.2013.05.066.

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29

Surikova, O. V., Z. G. Aliev, and A. G. Mikhailovskii. "Synthesis of 2-spiro-(1,2-dihydroperimid-2-yl)-5,5-dialkyl-2,3,5,6-tetrahydropyrrolo[2,1-a]-isoquinolin-3-ones." Chemistry of Heterocyclic Compounds 44, no. 12 (2008): 1500–1504. http://dx.doi.org/10.1007/s10593-009-0207-9.

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30

Gein, V. L., A. V. Popov, V. E. Kolla, N. A. Popova, and K. D. Potemkin. "Synthesis and biological activity of 1,4,5-triaryl-2,6-dihydroxo-3-aryl-methylene-2,3,4,6-tetrahydropyrrolo[3,4-b]pyrroles." Pharmaceutical Chemistry Journal 29, no. 9 (1995): 624–25. http://dx.doi.org/10.1007/bf02226391.

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31

Mashevskaya, I. V., R. R. Makhmudov, G. A. Aleksandrova, O. V. Golovnina, A. V. Duvalov, and A. N. Maslivets. "ChemInform Abstract: Synthesis, Antibacterial and Analgesic Activity of 3-Acyl-1,2,4,5-tetrahydropyrrolo[1,2-a]quinoxaline-1,2,4-triones." ChemInform 32, no. 38 (2010): no. http://dx.doi.org/10.1002/chin.200138145.

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32

MATSUO, K., M. KOBAYASHI, and S. UENO. "ChemInform Abstract: Synthesis of 10-Aryl-2-cyclohexyl-1,3,4,10-tetrahydropyrrolo(3,4-c)(1, 5)benzothiazepin-3-ones." ChemInform 25, no. 3 (2010): no. http://dx.doi.org/10.1002/chin.199403183.

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33

Volovenko, Yulian M., and Elizaveta V. Resnyanskaya. "Regioselective heteroannelation in quinazolin-4-one derivatives. Synthesis of 2,5-dioxo-1,2,4,5-tetrahydropyrrolo[1,2-a]quinazoline-3-carbonitriles." Mendeleev Communications 12, no. 3 (2002): 119–20. http://dx.doi.org/10.1070/mc2002v012n03abeh001580.

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34

GEIN, V. L., A. V. POPOV, V. E. KOLLA, N. A. POPOVA, and K. D. POTEMKIN. "ChemInform Abstract: Synthesis and Biological Activity of 1,4,5-Triaryl-2,6-dioxo-3- arylmethylene-2,3,4,6-tetrahydropyrrolo(3,4-b)pyrroles." ChemInform 27, no. 32 (2010): no. http://dx.doi.org/10.1002/chin.199632164.

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35

Bailey, TS, JB Bremner, L. Pelosi, BW Skelton та AH White. "Synthesis and X-Ray Crystal Structure of 8,9-Dimethoxy-4-methyl-3-phenyl-2,3,5,6-tetrahydropyrrolo[2,1-α]isoquinolinium Iodide". Australian Journal of Chemistry 48, № 8 (1995): 1437. http://dx.doi.org/10.1071/ch9951437.

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N-Methylation of 6,7-dimethoxy-1-(2�-phenylcyclopropyl)-3,4-dihydroisoquinoline (3b) with iodomethane in refluxing acetone gave the modified Cloke rearrangement product, 8,9-dimethoxy-4-methyl-3-phenyl-2,3,5,6-tetrahyropyrrolo[2,1-a] isoquinolinium iodide (5b), a new derivative of the pyrrolo [2,1-a] isoquinoline skeleton, together with the methiodide salt (4b) of (3b). The structure of (5b) was confirmed by X-ray crystallographic analysis.

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36

Trushkov, Igor V., Tatyana A. Nevolina, Vitaly A. Shcherbinin, Lyudmila N. Sorotskaya, and Alexander V. Butin. "ChemInform Abstract: Furan Ring Opening-Pyrrole Ring Closure. A Simple Route to 1,2,3,4-Tetrahydropyrrolo[1,2-a]pyrazin-3-ones." ChemInform 44, no. 44 (2013): no. http://dx.doi.org/10.1002/chin.201344113.

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37

Bozdyreva, K. S., I. V. Smirnova, and A. N. Maslivets. "Five-Membered 2,3-Dioxo Heterocycles: L. Synthesis and Thermolysis of 3-Aroyl- and 3-Hetaroyl-5-phenyl-1,2,4,5-tetrahydropyrrolo[1,2-a]quinoxalin-1,2,4-triones." Russian Journal of Organic Chemistry 41, no. 7 (2005): 1081–88. http://dx.doi.org/10.1007/s11178-005-0296-6.

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Zhang, Can, Gong-jian Pan, and Ai-bao Xia. "Synthesis and Crystal Structure Characterization of (6R,7aS)-1,1-Diphenyl-6-(4-vinylbenzyloxy)tetrahydropyrrolo[1,2-c]oxazol-3(1H)-one." Molecular Crystals and Liquid Crystals 623, no. 1 (2015): 297–304. http://dx.doi.org/10.1080/15421406.2015.1011467.

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Medvedeva, Svetlana M., and Khidmet S. Shikhaliev. "(3+2) Cycloaddition reactions in the synthesis of C(4)–N(5)-condensed tetrahydropyrrolo[3,4-c]pyrrole-1,3-diones (microreview)." Chemistry of Heterocyclic Compounds 52, no. 9 (2016): 687–89. http://dx.doi.org/10.1007/s10593-016-1949-9.

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Volovenko, Yulian M., and Elizaveta V. Resnyanskaya. "ChemInform Abstract: Regioselective Heteroanellation in Quinazolin-4-one Derivatives. Synthesis of 2,5-Dioxo-1,2,4,5-tetrahydropyrrolo[1,2-a]quinazoline-3-carbonitriles." ChemInform 33, no. 45 (2010): no. http://dx.doi.org/10.1002/chin.200245134.

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Nadkarni, Dwayaja, Feng Wang, Wei Wang, et al. "Synthesis and In Vitro Anti-Lung Cancer Activity of Novel 1, 3, 4, 8- Tetrahydropyrrolo [4, 3, 2-de]quinolin-8(1H)-o ne Alkaloid Analogs." Medicinal Chemistry 5, no. 3 (2009): 227–36. http://dx.doi.org/10.2174/157340609788185873.

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BAILEY, T. S., J. B. BREMNER, L. PELOSI, B. W. SKELTON, and A. H. WHITE. "ChemInform Abstract: Synthesis and X-Ray Crystal Structure of 8,9-Dimethoxy-4-methyl-3- phenyl-2,3,5,6-tetrahydropyrrolo(2,1-a)isoquinolinium Iodide." ChemInform 26, no. 51 (2010): no. http://dx.doi.org/10.1002/chin.199551180.

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Degutyte, Rimgaile, Algirdas Sackus, and Ulf Berg. "Synthesis of 1,5,6,10b-tetrahydroimidazo[2,1-a]isoquinolin-2(3H)-one derivatives and their rearrangement to 2,3,5,6-tetrahydropyrrolo[2,1-a]isoquinoline-3-carboxamides." Journal of Chemical Research 2001, no. 12 (2001): 540–42. http://dx.doi.org/10.3184/030823401103168811.

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Navailles, Sylvia, Mélanie Lagière, Audrey Roumegous, et al. "Serotonin2C ligands exhibiting full negative and positive intrinsic activity elicit purposeless oral movements in rats: distinct effects of agonists and inverse agonists in a rat model of Parkinson's disease." International Journal of Neuropsychopharmacology 16, no. 3 (2013): 593–606. http://dx.doi.org/10.1017/s1461145712000417.

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Abstract This study examined in naive or hemiparkinsonian rats the effect of various serotonin 2C (5-HT2C) receptor ligands differing in their intrinsic activity at 5-HT2C receptors on purposeless oral movements, a motor response integrated in the basal ganglia. Intraperitoneal administration of a non-selective [meta-chlorophenylpiperazine (m-CPP) 0.1–3 mg/kg], preferential [S-2-(6-chloro-5-fluoroindol-1-yl)-1-methylethylamine, Ro60-0175, 0.1–3 mg/kg] or selective [(7bR,10aR)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1hi]indole, WAY163909, 0.3–10 mg/kg] 5-HT2C agonists

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Wilson-Konderka, Cody, Alan J. Lough та Costa Metallinos. "(+)-trans-Chlorido{2-[(Rp)-2-(methylsulfanyl)ferrocenyl]-2,5,6,7-tetrahydropyrrolo[1,2-c]imidazol-3-ylidene}bis(triphenylphosphane-κP)palladium(II) hexafluoridophosphate dichloroform disolvate". Acta Crystallographica Section E Crystallographic Communications 72, № 9 (2016): 1330–34. http://dx.doi.org/10.1107/s2056989016013190.

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The title solvated complex, [FePd(C5H5)(C12H13N2S)Cl(C18H15P)2]PF6·2CHCl3, bearing a chiral ferrocenyl pyrroloimidazolylideneN-heterocyclic carbene (NHC) ligand, was synthesized by oxidative addition of a chloroimidazolium salt to Pd(PPh3)4. The PdIIion is coordinated in a slightly distorted square-planar coordination geometry, with the Cl atomtransto the coordinating C atom of the pyrroloimidazolylidene ligand. The complex features a pendant thioether group that is not involved in coordination to Pd. In the crystal, weak C—H...F and C—H...π interactions connect the components of the structure

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Pellegrino, Sara, Francesca Clerici, Alessandro Contini, Samantha Leone, Tullio Pilati, and Maria Luisa Gelmi. "Chemoselective asymmetric synthesis of C-3a-(3-hydroxypropyl)tetrahydropyrrolo[2,3-b]indole and C-4a-(2-aminoethyl)-tetrahydropyrano[2,3-b]indole derivatives." Tetrahedron 65, no. 10 (2009): 1995–2004. http://dx.doi.org/10.1016/j.tet.2009.01.004.

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Ko, Kwangseok, and Youngdo Won. "Quantitative structure and aldose reductase inhibitory activity relationship of 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-4-spiro-3′-pyrrolidine-1,2′,3,5′-tetrone derivatives." Bioorganic & Medicinal Chemistry 13, no. 5 (2005): 1445–52. http://dx.doi.org/10.1016/j.bmc.2004.12.034.

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Martínez, Roberto, Gema López, and Avila Z. J. Gustavo. "Synthesis and spectral properties of 6H-1-(2-, 3- and 4-R-Phenyl)-2,7,7-trimethyl-4,5,7,8-tetrahydropyrrolo[3,2-c]azepin-4-ones." Journal of Heterocyclic Chemistry 32, no. 2 (1995): 491–93. http://dx.doi.org/10.1002/jhet.5570320218.

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Gopalan, Sivaperumal, Kannnan Kulanthai, Gnanavel Sadashivam, Perumal Pachiappan, Sowmiya Rajamani, and Deepak Paramasivam. "Extraction, isolation, characterization, semi-synthesis and antiplasmodial activity of Justicia adathoda leaves." Bangladesh Journal of Pharmacology 11, no. 4 (2016): 878. http://dx.doi.org/10.3329/bjp.v11i4.28569.

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<p>There is a need to investigate the new sources of antimalarial drugs which are more effective against Plasmodium falciparum. The present study was undertaken to evaluate the in vitro antiplasmodial activity of vasicinone, vasicine and 9-oxo-1, 2, 3, 9-tetrahydropyrrolo [2,1-b]quinazolin-3-yl acetate (VA-1). Vasicinone and vasicine were extracted from the leaves of Justicia adhatoda. The novel compound VA-1 was synthesized from alkaloid the alkaloid vasicine, which was isolated from the ethanol extract of J. adhatoda leaves. Vasicine (IC<sub>50</sub> = 89.8 µg/mL) and vasic

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Haleema, Simimole, Chithra Gopinath, Zabeera Kallingathodi, Grace Thomas, and Prasad L. Polavarapu. "Medicinally Significant Enantiopure Compounds from Garcinia Acid Isolated from Garcinia gummi-gutta." Symmetry 16, no. 10 (2024): 1331. http://dx.doi.org/10.3390/sym16101331.

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Garcinia gummi-gutta, commonly known as Garcinia cambogia (syn.), is a popular traditional herbal medicine known for its role in treating obesity, and has been incorporated into several nutraceuticals globally for this purpose. The fruit rind is also used as a food preservative and a condiment because of its high content of hydroxycitric acid, which imparts a sharp, sour flavour. This review highlights the major bioactive compounds present in the tree Garcinia gummi-gutta, with particular emphasis on (2S, 3S)-tetrahydro-3-hydroxy-5-oxo-2,3-furan dicarboxylic acid, commonly referred to as garci

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