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1
Parisot, Joséphine. "COUP-TFI est nécessaire dans la différentiation et la migration des granules du gyrus denté." Thesis, Nice, 2015. http://www.theses.fr/2015NICE4089/document.
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L’hippocampe est un composant majeur du cerveau des mammifères et joue d'importants rôles dans la mémoire, l’apprentissage et la navigation spatiale. Il comprend deux régions distinctes: les champs ammoniens et le gyrus denté (DG). Pendant ma thèse, je me suis intéressée au facteur de transcription COUP- TFI, jouant des rôles clefs dans la spécification et migration neocorticale. Peu de choses sont connues sur son rôle dans l’hippocampe. COUP-TFI y est exprimé en gradient dans les progéniteurs et dans les neurones différentiés, et est fortement localisé dans le neuroépithelium du DG. Le but de ma thèse était de déchiffrer le rôle de COUP-TFI dans le développement de l’hippocampe, au cours de la différentiation et migration des granules, population principale du DG. À l’aide de lignées de souris dans lesquelles COUP-TFI est soit inactivé dans les progéniteurs soit seulement dans les cellules différentiées, j’ai montré que l’absence de COUP-TFI induit différents degrés d’altérations. En l’absence de COUPTFI dans les progéniteurs, les précurseurs du DG se différentient précocement, ont une prolifération réduite et leur migration est altérée. De plus, les afférences du cortex n’innervent pas le DG septal et l’apoptose y est accrue. Le DG en résulte fortement réduit chez adulte, particulièrement dans la région septal. La perte de COUP-TFI dans les cellules différentiées n’entraine que des anomalies mineures et transitoires. Ainsi, mes résultats indiquent que COUP-TFI régule la différentiation et migration des granules, particulièrement au niveau des progéniteurs, et propose COUP-TFI comme un nouveau facteur requis dans le développement et le fonctionnement de l’hippocampeThe hippocampus is a major component of the mammalian brain and plays important roles in memory, learning, and spatial navigation. It comprises two distinct regions: the hippocampus proper and the dentate gyrus (DG). During my thesis, I have challenged the role of the strong transcriptional regulator COUP-TFI, playing key roles during neocortical specification and migration. Yet, little is known about its involvement in the hippocampus. COUP-TFI is expressed in a gradient fashion in both proliferating progenitors and differentiated neurons in the hippocampus, and is highly localized in the DG neuroepithelium. The aim of my thesis was thus to decipher the role of COUP-TFI in the developing hippocampus, and specifically in cell differentiation and migration of granule cells, the major DG cell population. Using two mutant mouse lines, in which COUP-TFI is either ablated in progenitors, or solely in post-mitotic cells, I have shown that absence of COUP-TFI induces different degrees of growth impairments. In the absence of COUP-TFI in progenitors, DG precursors tend to differentiate precociously, exhibit reduced proliferation and granule cells migration is impaired. Postnatally, inputs from the cortex fail to innervate the septal DG and apoptosis is abnormally increased. The DG results strongly reduced in adult, particularly in the septal region. Loss of COUP-TFI in differentiated cells leads only to minor and transient defects. Together, my results indicate that COUP-TFI is involved in regulating granule cell differentiation and migration predominantly in progenitors, and propose COUPTFI as a novel transcriptional regulator required in hippocampal development and functions
2
Kim, Jerin. "Predictive and Concurrent Validity of the Tiered Fidelity Inventory (TFI)." Thesis, University of Oregon, 2019. http://hdl.handle.net/1794/24563.
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This study evaluated the predictive and concurrent validity of the Tiered Fidelity Inventory (TFI). Structural equation modeling was applied to test the associations between the TFI and student outcomes. First, a total of 1,691 schools with TFI Tier 1 in 2016-17 and school-wide discipline outcomes in 2015-16 and 2016-17 were targeted, finding a negative association between TFI Tier 1 and differences between African American and non-African American students in major office discipline referrals (ODR) per 100 students per day in elementary schools. A sensitivity test with schools with TFI Tier 1, 2, and 3 was conducted, showing a negative association between TFI Tier 1 and the square root of major ODR rates in elementary schools.
Second, TFI Tier 1 was positively related to the proportions of students meeting or exceeding state-wide standards in reading from 1,361 schools with TFI Tier 1 and academic outcomes in 2014-15 and 2015-16. Also, the association between TFI Tier 1 and academic outcomes was found to be stronger when schools implemented SWPBIS for 6 or more years. A sensitivity test with schools with TFI Tier 1, 2, and 3 indicated positive associations between TFI Tier 1 and the proportions of students meeting or exceeding state-wide standards in both subjects.
Third, TFI Tier2 was positively associated with the logit of proportions of students with CICO daily points from 570 schools with TFI Tier 2 in 2016-17 and CICO outcomes in 2015-16 and 2016-17. Fourth, correlations between the Evaluation subscale of TFI Tier 1 or 2 and relevant measures in 2016-17 were tested from 2,379 schools. TFI Tier 1 Evaluation was positively correlated with counts of TFI administrations, number of fidelity measures, and counts of viewing SWIS Reports. These correlations were significant except for ODRs by staff. Also, TFI Tier 2 Evaluation was significantly positively correlated with years of SWPBIS implementation, years of CICO-SWIS implementation, and counts of viewing CICO Reports except student period, and negatively with counts of viewing student single period.
These findings were discussed by comparing them with previous research findings, suggesting implications for future research and practice, and addressing research limitations.
3
Pickens, Brandy S. "THE ROLE OF COUP-TFI DURING RETINOIC ACID INDUCED ENDODERMAL DIFFERENTIATION OF P19 CELLS." Diss., Temple University Libraries, 2012. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/196883.
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BiochemistryPh.D.
ABSTRACT Retinoic acid (RA) is a positive regulator of P19 EC cell differentiation. Pre-B cell leukemia transcription factors (PBXs) act in conjunction with homeobox genes during cell differentiation. PBX mRNA and protein levels are increased rapidly in P19 cells during RA-induced differentiation. However, silencing of PBX expression in P19 cells (AS cells) results in a failure of these cells to differentiate upon RA treatment. Chicken Ovalbumin Upstream Promoter Transcription Factor I (COUP-TFI) and Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) are orphan members of the steroid-thyroid hormone superfamily. The mRNA and protein levels of both COUP-TFI and COUP-TFII are low in proliferating wild type P19 EC cells. However, when wild type P19 cells are induced to differentiate upon RA treatment, COUP-TFI and COUP-TFII mRNA and protein levels are dramatically increased while the levels of pluripotency associated gene products are strikingly reduced. Conversely, COUP-TFI and COUP-TFII mRNA levels fail to be elevated upon RA treatment in PBX AS P19 EC cells. Therefore it was hypothesized that COUP-TFs may be downstream targets of PBX and required factors mediating the RA-dependent differentiation cascade in P19 cells. To determine the role of COUP-TFI during differentiation of P19 cells, PBX AS cells that inducibly express V5 tagged COUP-TFI using the Tet-Off® Advanced Inducible Gene Expression system were prepared. Using this system, we demonstrate that exogenous COUP-TFI expression, in a dose-dependent fashion, leads to growth inhibition, modest cell cycle disruption and early apoptosis. Furthermore, using this cell model which inherently is incapable of undergoing RA-mediated differentiation due to blockage of PBX induction, we demonstrate that a supraphysiological level of COUP-TFI expression can overcome the blockage of RA-dependent differentiation in PBX AS cells. However, AS cells expressing a physiological level of COUP-TFI differentiate to endodermal cells only upon treatment with RA. Additionally, gene expression studies indicate that the reductions of pluripotency maintenance genes observed in the COUP-TFI expressing cells are similar to that of wild type P19 cells (upon RA treatment) suggesting that COUP-TFI expression is a driving force towards loss of pluripotency. Moreover, gene expression studies indicate COUP-TFI is involved in the regulatory modulation of at least two RA response genes, CYP26A1 and HoxA1, indicating that COUP-TFI may have some effect on either maintaining or reducing these genes expression levels when COUP-TFI becomes expressed. COUP-TFII is expressed as two distinct variants, Variant 1(V1) and Variant 2 (V2). V1 is the variant that functions as a classical nuclear receptor by binding target DNA sequences and affecting gene transcription whereas V2 is a truncated form of V1 lacking the ability to bind DNA. We therefore hypothesized that V2 could serve as a dominant negative receptor by limiting the amount of functional V1 in the cell. Unexpectedly, we found using P19 cells that overexpress V2 that RA-mediated differentiation proceeded normally suggesting V2 does not function as a dominant negative repressor. Taken together, these studies demonstrate for the first time (i) that COUP-TFI functions as a physiologically relevant regulator during RA-mediated endodermal differentiation of P19 cells and (ii) COUP-TFII V2 is endogenously expressed in P19 cells; however its role during RA-mediated differentiation remains unclear.
Temple University--Theses
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Bueno, Natalia Fernanda. "Caracterização de dois pares efetor/inibidor associados ao sistema de secreção tipo IV de Xanthomonas citri." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-24082018-094918/.
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O sistema de secreção tipo IV (T4SS) da família de bactérias Xanthomonadaceae transfere efetores (X-Tfes) com a capacidade de matar outras bactérias, conferindo uma vantagem em comunidades bacterianas mistas para colonizar diferentes nichos como o solo ou as superfícies das plantas. Os X-Tfes possuem diferentes domínios putativos com atividades hidrolíticas contra componentes do envelope celular bacteriano do tipo: glicohidrolases, transglicosilases, amidases e lipases. Os X-Tfes por sua atividade biológica inata podem ocasionar dano intracelular para a bactéria que os produz. Para se proteger contra estas atividades, também são produzidas lipoproteínas com função inibitoria (X-Tfis) localizadas no periplasma. Os genes que codificam os X-Tfes e os X-Tfis estão organizados em operons, o que permite gerar os pares efetor/inibidor simultaneamente. Entre os potenciais X-Tfes do fitopatógeno Xanthomonas citri estão Xac1918 e Xac0574. Xac1918 é uma proteína com um domínio da superfamília da lisozima e um domínio conhecido como RTX (Repeats in Toxin) de ligação ao cálcio, enquanto Xac0574 tem um domínio da superfamília da lipase 3. Os seus possíveis inibidores, Xac1917 e Xac0573 respectivamente, apresentam um peptídeo sinal no N-terminal contendo o lipobox representativo das lipoproteínas. As proteínas Xac0574 e Xac0573 são monômeros em solução que formam um complexo estável 1:1, favorecido termodinamicamente (ΔG°= -12 Kcal/mol) com uma constante de dissociação de 2,45 nM, garantindo que a bactéria fique protegida contra os efeitos nocivos de Xac0574 quando é produzida intracelularmente. Xac0574 é uma fosfolipase A1, sem atividade lisofosfolipase, com a capacidade de hidrolisar os três fosfolipídios majoritários que compõem a membrana celular bacteriana, fosfatidilglicerol (PG), cardiolipina e fosfatidiletanolamina (PE), mostrando uma aparente preferência pelo último. A atividade enzimática de Xac0574 explica a forte inibição do crescimento celular em E. coli após da sua indução heteróloga, já que gera uma diminuição de quase 10 vezes da população celular comparada com a cultura não induzida com a mesma construção. Poroutro lado, Xac0573 inibe efetivamente a atividade enzimática de Xac0574 ao formar o complexo, além de não ter atividade fosfolipase nem lisofosfolipase. Foram produzidos cristais da Xac1918 e Xac0573 que difrataram com uma resolução de 3,0 e 2,5 Å, respectivamente. Porém, só foi gerado um modelo de Xac0573. Xac0573 está composta por duas folhas β antiparalelas com uma topologia característica de β sanduíche Com uma pequena hélice e duas voltas. Um alinhamento de homólogos de Xac0573 identificou nas extremidades da proteína as regiões conservadas, constituindo duas possíveis interfaces de interação que podem ser as responsáveis por bloquear o acesso dos fosfolipídios ao sítio catalítico ou impedir os rearranjos estruturais de Xac0574 que são necessários para a sua atividade enzimática. Adicionalmente, a topologia da Xac0573 é semelhante do domínio C2, conhecido em eucariotos como domínio de ligação ao lipídio e ao cálcio, e está envolvido em processos de sinalização de segundos mensageiros lipídicos, proteínas de trafego de membranas e mecanismos de fusão de membranas. Nossos resultados apontam para uma nova função biológica do domínio C2 como um inibidor enzimático intracelular em bactérias.The type IV secretion system (T4SS) of the bacteria family Xanthomonadaceae transfers effectors (X-Tfes) with that can kill other bacterial cells, conferring an advantage to the bacterial community during colonization of different niches in the soil or on the plant surface. The X-Tfes possess different putative domains with hydrolytic activity against components of the bacterial cellular envelope, including glycohydrolase, transglycolase, amidase and lipase domain. The innate biological activity of X-Tfes can cause intracellular damage. Therefore, the bacteria that produce them also produce lipoproteins with inhibitor function (X-Tfis) located in the periplasm for their protection. The genes that code for X-Tfes and X-Tfis are organized in operons that allow for their simultaneous expression. Among the X-Tfes of the phytopathogen Xanthomonas citri are Xac1918 and Xac0574. Xac1918 is carries a lysozyme superfamily domain, as well as a domain known as RTX (Repeats in Toxic) predict to bind calcium, while, Xac0574 has a domain belonging to the lipase 3 superfamily. Their possible inhibitors, Xac1917 e Xac0573 respectively, carry an N-terminal signal peptide containing a lipobox found in bacterial lipoproteins. The Xac0574 and Xac0573 proteins are both monomers in solution, They can form a stable 1:1 complex, that is thermodynamically favored (ΔG°= -12 Kcal/mol) with a dissociation constant of 2,45 nM. This affinity ensure that the bacterium is protected against the harmful effects of Xac0574 when it is produced intracellularly. We show that Xac0574 is a phospholipase A1, without lisophospholipase activity, and is able to hydrolyze the three most common phospholipids found in the membranes of Gram negative bacteria, namely phosphatidylglycerol (PG), cardiolipin and phosphatidylethanolamine (PE), presenting an apparent preference for PE. The enzymatic activity of Xac0574 explains the strong inhibition of growth of E. coli cells after its heterologous induction: a nearly 10-fold decrease in the cell population is observed when compared to the non-induced culture with the same construct. On the other hand, Xac0573 effectively inhibits the enzymatic activity of Xac0574. Furthermore, Xac0573 does not possess when forming the complex, besides not having phospholipase nor lysophospholipase activity.Crystals of Xac1918 and Xac0573 were produced which diffracted with to resolution of 3.0 and 2.5 Å, respectively. However, we were able to resolve the structure of only Xac0573. Xac0573 is composed of two anti-parallel sheet that form a β-sandwich with three small helices. An alignment to Xac0573 homologs identified conserved regions at the ends of the protein that constitute two possible interfaces of interaction that may be responsible for blocking the access of the phospholipids to the catalytic site or impede the structural rearrangements of Xac0574 that are necessary for its enzymatic activity. Additionally, the topology of Xac0573 is similar to that to C2 domains, known in eukaryotes to bind lipids and calcium and to be involved in signaling processes mediated by lipid second messengers, membrane trafficking and membrane fusion mechanisms. Our results point to a new biological function of the C2 domain as an intracellular enzyme inhibitor in bacteria.
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Gallais, Rozenn. "Chromatine et transcription : influence du récepteur nucléaire orphelin COUP-TFI dans les cellules pluripotentes P19." Rennes 1, 2007. http://www.theses.fr/2007REN1S028.
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La différenciation cellulaire requiert la modulation de l’expression de son patrimoine génétique, associée à une relocalisation de loci de gènes au sein du noyau et à la réorganisation structurale de la chromatine, notamment au niveau de modifications épigénétiques telle que la méthylation de l’ADN sur les CpGs. Ces processus ont été étudiés dans les cellules P19, dont la différenciation neuronale peut être induite par l’acide rétinoïque. Lors de cette différenciation, la transcription du gène vitronectine (Vn) est activée, le récepteur nucléaire orphelin COUP-TFI intervenant dans cette régulation. Afin de comprendre les évènements associés à la transition d’un gène d’un locus chromatinien répressif vers un environnement permissif, les mécanismes permettant l’activation du gène Vn par COUP-TFI ont été analysés. Un complexe TDG/p68/Dnmt3 impliqué dans la déméthylation des CpGs du promoteur Vn a ainsi été caractérisé. De plus, nous avons montré l’existence d’une focalisation de COUP-TFI au sein de foyers ARN Polymérase II, reliée à un recrutement de COUP-TFI sur de plus large régions du génome que les promoteurs de ses gènes ciblesCell differentiation is associated with the modulation of the expression of its genome. These regulations are connected with the relocation of genomic loci from silent to active domains, occurring in parallel with specific variations of incidence of given epigenetic marks, such as DNA methylation on CpGs. These processes have been considered in P19 cells, which neuronal differentiation can be induced by retinoic acid. During this process, the vitronectine (Vn) gene transcription is activated through mechanisms involving the orphan nuclear receptor COUP-TFI. Underlying processes of these regulations have been studied, in order to decipher molecular processes remodeling a chromatin organization from a repressed to an active state. Our results indicate that a TDG/p68/Dnmt3 complex is recruited to the Vn genomic region, associated with the demethylation of the CpGs present within this region. Furthermore, we demonstrated that COUP-TFI accumulates into RNA Polymerase II foci, associated with the engagement of COUP-TFI on genomic regions broader that are than the promoters of its target genes
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Cruz, Luciana Oliveira. "Identificação e seleção de novos genes humanos associados a tumores a partir de dados obtidos no projeto Transcript Finishing Initiative (TFI)." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-16112007-111539/.
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Após o seqüenciamento completo do genoma humano, a busca e caracterização do conjunto completo de genes humanos constitui-se no principal desafio nesta área de investigação, sendo o passo limitante para o progresso na exploração dos dados contidos no seqüenciamento deste genoma. O projeto de transcriptoma denominado \"Transcript Finishing Initiative\" (TFI) surgiu neste contexto, com o objetivo principal de gerar fragmentos parciais de transcritos humanos, que não haviam sido descritos previamente e determinar sua seqüência, para iniciar a caracterização de novos genes humanos. A estratégia utilizada foi q alinhamento de todas as seqüências ORESTES e ESTs disponíveis com a seqüência pública do genoma humano e o agrupamento j c1usterização destas com base nas coordenadas deste genoma. Algumas das regiões que não eram cobertas por estas seqüências foram, então, completadas, por RT-PCR, utilizando-se primers ancorados nos clusters vizinhos. Cada par de clusters de ESTs selecionado para validação experimental foi designado como uma Unidade do \"Transcript Finishing\" (TFU), tendo sido validadas experimentalmente, pelo grupo TFI, Um total de 211 TFUs foram validadas, sendo que 197 seqüências consenso foram submetidas ao Genbank (CF272536-CF272733). Atualmente, apenas um pequeno número destas seqüências ainda são considerados genes novos, sem que haja um cDNA depositado em banco de dados; contudo para um número considerável destas TFUs não existe qualquer caracterização sobre sua função. Na tentativa de contribuir para melhor caracterização dos genes identificados no projeto TFI, e tendo, como base, a linha de pesquisa do laboratório, que busca genes diferencialmente expressos envolvidos em transformação maligna/tumorigênese, o presente trabalho propôs a utilização das seqüências TFUs para estudar sua possível associação com tumores de glia humanos e outros tipos de tumores (de próstata e de mama). Para tanto, as TFUs foram analisadas \"in silico\" para estabelecer seu grau de ineditismo como um novo gene ou um gene sem função conhecida, e, para análise de sua expressão diferencial entre tecidos normais e tumorais de cérebro, próstata e mama. Para validar estas análises computacionais na bancada, foram gerados macro- e microarranjos de DNA utilizando-se as TFUs disponíveis como clones físicos ou amplicons, para o rastreamento com sondas das linhagens celulares A172 e T98G de glioblastomas. Os resultados das análises destes dados foram confirmados por PCR quantitativo tanto nas linhagens como em amostras clínicas de astrocitomas que apresentam diversos graus de malignidade. Como resultado, foi possível organizar um Banco de Clones Físicos de TFUs, além de identificar e selecionar uma TFU (168), cuja expressão correlaciona diretamente com o grau de malignidade dos tumores de glia. Esta seqüência corresponde a um novo gene, já que não existe a seqüência de cDNA completo nos bancos de dados. Em vista disto, a TFU168 foi selecionada para estudos funcionais posteriores, que já estão em andamento, através da obtenção de suaseqüência completa de cDNA para ensaios de superexpressão e do silenciamento gênico através de RNAi.Upon complete sequencing of the human genome, identification and characterization of the complete set of human genes constitutes the major challenge in this research field, constituting the limiting step for progress in exploration of the informations contained in the genome sequencing data. The Transcript Finishing Initiative (TFI) transcriptome project arose in this context, aiming at the generation, sequencing and characterization of partial new human transcripts and genes. The strategy adopted was the alignment of the alI the available ORESTES and EST sequences data with the public human genome sequence and their clusterization based on the coordinates of this genome. Thus, some of the regions which were not cover by ESTs and ORESTES (gaps) were then completed by RT-PCR using primers anchored in the neighboring clusters. Each pair of EST clusters selected for experimental validation was named Transcript Finishing Unit (TFU). A large number (211) of TFU s were validated and 197 -consensus sequences were submitted to the Genbank (CF272536-CF272733). At present, only a few of these sequences are considered as new genes without a full-Iength cDNA sequence deposited in the data bank, however, no functional characterization is yet available for a large number of these sequences. In an attempt to contribute to further characterization of these genes identified in the TFI project and keeping in mind the main interest of our laboratory, which is the identification of differentially expressed genes in tumor versus normal tissue, the present work aims at utilizing these TFUs to find differentially expressed genes associated with human glial tumors and with other kinds of tumors. To this end, these sequences were first subjected to in silico analysis in order to establish their degree of ineditism (new sequences and/or sequences with unknown function) and their expression profile between normal and tumoral tissues of brain, mammary gland and prostate. To validate this computational analysis, DNA macro- and microarrays were generated with the TFU sequences and screened with cDNA probes obtained from the A172 and T98G glioblastomas cell lines. The results of these screenings were confirmed by quantitative PCR both in cell lines and in tumor samples of different degrees of malignancy. The results obtained in this work allowed the organization of a TFUs Physical Clones Bank and the identification and selection of one sequence (TFU 168), whose expression is directly re1ated to the degree of tumor malignancy. This sequence constitutes a new gene, since no complete cDNA sequence is available in the data banks. Therefore, TFU168 was selected for further functional studies by obtaining its full-Iength cDNA sequence to be used for over expression by silencing this gene using RNAi.
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Magrinelli, Elia. "Le récepteur nucléaire orphelin COUP-TFI contrôle l’identité sensorielle et l'activité neuronale dans les cellules post-mitotiques du néocortex chez la souris." Thesis, Nice, 2016. http://www.theses.fr/2016NICE4037/document.
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Le néocortex est une région du cerveau qui traite toutes les entrées sensorielles et créé des réponses comportementales. Il est subdivisé en zones fonctionnelles, chacune ayant une cytoarchitecture, un motif d’expression génique et un profil de connectivité spécifiques. L'organisation en zones est pré-modelée par des gènes organisateurs, et ensuite affinée par l’activité sensorielle. Dans cette étude, j'ai étudié d'abord si ce pré-modelage est établi dans les progéniteurs et/ou les cellules post-mitotiques, et si l'activité neuronale spontanée est nécessaire pour l’établissement de la connectivité correcte entre néocortex et thalamus, station relais principale des données sensorielles. Avec l'aide d'une série de souris transgéniques, j’ai montré que la fonction du gène organisateur COUP-TFI est suffisante et nécessaire pour organiser l'identité sensorielle dans les cellules post-mitotiques, et que COUP-TFI régule l'activité intrinsèque des neurones corticaux, influençant la bonne intégration des entrées thalamiques dans le cortex somatosensoriel. J’ai montré que COUP-TFI contrôle directement l'expression du gène Egr1, qui dépend fortement de l'activité neuronale. COUP-TFI et Egr1 agissent sur l'acquisition de la morphologie des cellules étoilées dans les neurones de la couche 4, cibles principales des axones thalamiques et trait typique des zones somatosensoriels primaires. En conclusion, ce travail montre que le pré-modelage cortical dépend primordialement d’un programme génétique établi dans les cellules post-mitotiques et que l'activité intrinsèque et les propriétés génétiques agissent ensemble pour façonner l'organisation des premiers circuits dans le néocortexThe neocortex is a region of the brain that processes all sensory inputs creating appropriate behavioral responses. It is subdivided into functional areas, each with a specific cytoarchitecture, gene expression pattern and connectivity profile. The organization into areas is pre-patterned by the action of areal patterning genes, and subsequently refined by sensory evoked activity. In this study, I have first investigated whether early areal patterning is committed in progenitor and/or post-mitotic cells, and then assessed whether spontaneous neuronal activity is required in establishing correct connectivity between the neocortex and the thalamus, the principal relay station of peripheral sensory inputs. With the help of a series of transgenic mice, my work showed that the function of the areal patterning gene COUP-TFI is sufficient and necessary to organize sensory identity in post-mitotic cells, and that COUP-TFI regulates intrinsic activity properties of cortical neurons, and thus proper integration of thalamic inputs into the somatosensory cortex. In particular, I found that COUP-TFI directly controls the expression of the immediate early gene Egr1, which expression levels strongly depend on neuronal activity. Both COUP-TFI and Egr1 act on the acquisition of the stellate cell morphology of layer 4 neurons, the main targets of thalamic axons and a typical trait of primary somatosensory areas. In conclusion, this work demonstrates that cortical area patterning primordially depends on a genetic program established in post-mitotic cells and that intrinsic genetic and activity properties act together to shape the organization of early circuits in the neocortex
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Fackrell, Kathryn L. "Validation of a new questionnaire measure of tinnitus functioning and disability for use in the UK : the Tinnitus Functional Index (TFI)." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/33119/.
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The Tinnitus Functional Index (TFI) was developed in the USA as a standard for assessing the functional impact of tinnitus based on eight tinnitus-related domains. The finalised 25-item version was never formally validated. This PhD seeks to assess the psychometric properties of the questionnaire and evaluate its suitability as the tool of choice for use in the diagnostic and outcome assessment of tinnitus for clinical and research purposes in the UK. The primary objectives were to (i) determine whether the TFI is reliable, (ii) verify its factor structure, and (iii) evaluate its responsiveness to treatment-related change. These objectives were evaluated in two UK studies. The first was a prospective multi-centre longitudinal validation study in which 255 NHS patients were recruited from audiology clinics to complete the TFI over four different time points in a nine-month period. The second was a retrospective analysis of data collected on the TFI and a battery of other health questionnaires from 294 members of the general public who had previously participated in two-centre randomised controlled trial of a novel tinnitus device. Approaches to psychometric analysis included classical and modern test theories, including Rasch measurement theory. Both approaches led to similar conclusions. Seven of the eight subscales were reliable and valid in both studies, although not as sensitive as the original developers proposed. Classical testing showed the auditory subscale to be reasonably reliable, but Rasch modelling indicated that it did not measure the functional impact of tinnitus. The overall factor structure was not confirmed. The sleep and auditory subscales did not relate to the other subscales and did not fit the model. My recommendation is to calculate the composite TFI score using only six subscales. The sleep subscale should be scored separately and the auditory subscale should not be used.
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Celi, Guillaume. "Etude, applications et améliorations de la technique LVI sur les défauts rencontrés dans les technologies CMOS avancées 45nm et inférieur." Phd thesis, Université Sciences et Technologies - Bordeaux I, 2013. http://tel.archives-ouvertes.fr/tel-00904697.
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L'analyse de défaillances joue un rôle important dans l'amélioration des performances et de la fabrication des circuits intégrés. Des défaillances peuvent intervenir à tout moment dans la chaîne d'un produit, que ce soit au niveau conception, durant la qualification du produit, lors de la production, ou encore lors de son utilisation. Il est donc important d'étudier ces défauts dans le but d'améliorer la fiabilité des produits. De plus, avec l'augmentation de la densité et de la complexité des puces, il est de plus en plus difficile de localiser les défauts, et ce malgré l'amélioration des techniques d'analyses. Ce travail de thèse s'inscrit dans ce contexte et vise à étudier et développer une nouvelle technique d'analyse de défaillance basée sur l'étude de l'onde laser réfléchie le "Laser Voltage Imaging" (LVI) pour l'analyse de défaillance des technologies ultimes (inférieur à 45nm).
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Le, Dily François. "Interrelations entre le récepteur alpha des œstrogènes et le récepteur nucléaire coup-tfi dans le contrôle de la prolifération et de la différenciation de cellules mammaires." Rennes 1, 2006. http://www.theses.fr/2006REN1S090.
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Les œstrogènes (E2) sont connues pour leurs rôles dans la croissance des tumeurs mammaires. Ces hormones exercent leurs effets par l’intermédiaire de récepteurs spécifiques, les récepteurs des œstrogènes, ERα et ERβ. Les ER appartiennent à la superfamille des récepteurs nucléaires qui portent un domaine de liaison du ligand, un domaine d’interaction avec l’ADN et des fonctions de transactivation (AF-1 et AF-2) leur permettant d’agir comme des facteurs de transcription inductibles. Les récepteurs nucléaires orphelins COUP-TFI sont susceptibles de moduler l’activité du ERα. Afin d’appréhender l’impact des interrelations entre ERα et COUP-TFI au sein des cellules mammaires, nous avons établi des clones de cellules mammaires sur-exprimant stablement COUP-TFI. L’analyse de ces clones montre que COUP-TFI favorise la prolifération et stimule les capacités de migration de cellules ERα positives. COUP-TFI module sélectivement l’expression de gènes E2-régulés endogènes et exerce en particulier une stimulation de la fonction de transactivation AF-1 du ERα.
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Forcade, Edouard. "Immunobiologie de la GVH chronique humain : dérégulation de la réaction du centre germinatif et implication de la réponse Th17." Thesis, Bordeaux, 2016. http://www.theses.fr/2016BORD0439/document.
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La GVH chronique (cGVHD) est une complication fréquente de l’allogreffe de cellules souches hématopoïétiques (CSH) dont la physiopathologie demeure partiellement comprise. Les données disponibles ont établi le rôle des lymphocytes T (LT) et B (LB) au cours de la cGVHD, mais la qualité de leur interaction et les sous-types de LT impliqués restent à définir. L’interaction entre les LT et les LB se fait au niveau du centre germinatif (CG) aboutissant à la production de LB mémoires et de cellules productrices d’anticorps de haute affinité grâce aux signaux d’aide reçus par les LT folliculaires helpers (TFH) finement contrôlés par une population régulatrice (TFR). La possibilité d’interroger les évènements se déroulant au niveau du CG par l’analyse de leur contingent circulant (c) nous a permis de mieux comprendre la physiopathologie de la cGVHD. En effet, la signature phénotype des cTFH suggère un gain de fonction au cours de la cGVHD, confirmée par étude fonctionnelle, et corrélant avec le phénotype des LB observé. De plus, les mécanismes de régulation apparaissent défectueux au cours de la cGVHD, puisque les cTFR présentent un défaut numérique expliqué par un défaut de résistance à l’apoptose et de prolifération. D’autre part, nous avons analysé une population de LT CD4+CD146+CCR5+, leur conférant une capacité de migration au travers des structures endothéliales et vers les sites inflammatoires. Cette population est significativement augmentée au cours de la cGVHD, et les modèles murins de cGVHD recevant des splénocytes de souris CD146-/- voient leur score clinique amélioré. L’expression de CD146 est associée à une polarisation Th17 justifiant un traitement par TMP778 (inhibiteur de RORγt) améliorant la cGVHD chez la souris. L’analyse de ces populations révèle des anomalies de la balance effecteurrégulateur et de potentielles cibles thérapeutiques à évaluer en cliniqueChronic GVHD (cGVHD) remains a major complication of allogeneic stem cell transplantation and its pathogenesis poorly understood. Previous reports established the role of T cells and B cells during cGVHD, but the quality of their interaction and T cell subsets involved remain to be defined. T cell – B cell crosstalk occurs in the germinal center generating memory B cells and high affinity antibody secreting cells consecutively to signals provided by T follicular helper cells (TFH) which are tightly controlled by a regulatory subset (TFR). The opportunity to interrogate events occurring in the germinal center through the analysis of their circulating contingent (c), allowed us to better understand cGVHD pathogenesis. cTFH phenotypic signature suggest an enhanced function during cGVHD, confirmed in functional studies, and correlating with observed B cell phenotype. In addition, regulatory mechanisms appeared defective during cGVHD, as cTFR showed a numerical deficiency, explained by a defect in resistance to apoptosis and low proliferative capacity. We also studied a T cell subset expressing CD4+CD146+CCR5+, giving the capacity to migrate through endothelial structures and toward inflammatory sites. This population is significantly increased during cGVHD, and cGVHD murine models receiving splenocytes from CD146-/- mice showed improved clinical score. CD146 expression is associated with a Th17 polarization justifying a treatment by TMP778 (RORγt inhibitor) improving cGVHD in mice. The analysis of these different populations revealed an abnormal effector-regulator balance and potential therapeutic targets to evaluate in clinic
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OLIVEIRA, LEANDRO DUARTE DE. "THE CONNECTION BETWEEN THE POLITICS OF AFFIRMATIVE ACTION AND PERMANENCE IN THE SUPERIOR EDUCATION OF TEACHING FEDERAL INSTITUTIONS – TFI: THE SPECIFICITIES OF HOUSING BENEFIT FOR THE GRADUATION STUDENTS OF UFRJ." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2014. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=25126@1.
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PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIROA presente dissertação teve por objetivo analisar a relação complementar entre as novas políticas de acesso ao ensino superior público mais especificamente as ações afirmativas e a constituição das ações de assistência estudantil nas universidades federais. Foi utilizada como exemplo a assistência estudantil da Universidade Federal do Rio de Janeiro – UFRJ. Do rol de ações e serviços que essa universidade oferece ao corpo discente de graduação foi escolhido para estudo o benefício moradia devido a sua peculiar centralidade na atual conjuntura de expansão da política de educação superior e por fazer parte da estratégia de permanência, principalmente para os estudantes com dificuldades socioeconômicas e aqueles que migram em direção a UFRJ. Assim, o trabalho de campo foi realizado com os estudantes contemplados pelo benefício moradia no ano de 2012. A partir da análise do material empírico da pesquisa percebeu-se que o atual modelo de expansão do sistema de ensino superior tem promovido em parte a mobilidade estudantil entre as mais diferentes instituições de ensino presentes nas regiões do Brasil. No caso da UFRJ observou-se essa tendência após a adoção pela universidade do ENEM. Essa migração tem gerado forte pressão para o aumento de benefícios e serviços da assistência estudantil na UFRJ. Portanto, cresce a demanda por vagas para moradia discente no atual prédio da Residência Estudantil e para a criação de novos serviços que já foram assegurados pelo PNAES. Nesse ínterim há críticas sobre a focalização da assistência estudantil nos estudantes ditos pobres na universidade e, portanto maiores níveis de universalização de suas ações e serviços devem ser buscados para atender a contento toda a complexidade de problemas que interferem na trajetória acadêmica dos estudantes. A construção de ações de assistência estudantil eficazes é um elemento importante para a garantia de permanência na universidade.
The present dissertation had as objective to analyze the complement relation among the new access politics to the public superior education, more specifically the affirmative actions and the constitution of the student actions assistance in the federal universities. It was accomplished as an example of the student assistance the Federal University of Rio de Janeiro - UFRJ. The register of actions and services that this university offers to the student body of the graduation was chosen as a study of the habitation benefit because of its peculiar centrality in the current conjuncture of the politic expansion of the superior education and for be part of the strategy, mainly to the students that have socioeconomic difficulties and those that migrate to UFRJ. In this manner, the work camp was accomplished with students that are contemplated by the housing benefit in the year 2012. From the analysis of the empirical material of the investigation, it was noted that the current model of expansion of the superior teaching system has promoted in parts the student mobility among the most different teaching institutions existing in Brazil s regions. In the case of UFRJ it was observed this tendency after the introduction by the universities of the ENEM. This migration has been creating a strong pressure to the increase of the benefits and student assistance services in UFRJ. Because of this reason, it grows the request for vacancy to the student housing in the current building of the student residence and for the creation of new services that were already assured by the PNAES. In this interim there are criticisms about the focus of the student assistance in the students known as poor in the university and, so higher levels of universalization of its actions and services must sought to well attend all the problems complexity that interferes in the academic trajectory of the students. The construction of student actions assistance is an important element to the guaranty of the permanence in the university.
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Talami, Matteo. "Modeling of the Toroidal Field Insert coil for the ITER Project." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amslaurea.unibo.it/12916/.
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Il contenuto della tesi riguarda le analisi numeriche e sperimentali effettuate su un campione di cavo superconduttivo del sistema magnetico del reattore sperimentale per la fusione nucleare “ITER”. In particolare, il campione di cavo denominato “Toroidal Field Insert” o “TFI”, appartiene al sistema magnetico toroidale della macchina e viene inserito in un solenoide esterno in modo da replicare le condizioni di campo magnetico tipiche del normale funzionamento di questo conduttore. Le analisi sperimentali effettuate sul campione sono mirate alla caratterizzazione del comportamento durante un ipotetico ciclo di vita del cavo. I parametri principalmente studiati risultano essere: la caratterizzazione dello stato superconduttivo prima e dopo le varie sollecitazioni imposte, l’efficacia idraulica del raffreddamento e la stabilità termica del magnete. In modo complementare alla analisi dei dati sperimentali, due modelli numerici a diverse scale sono stati sviluppati e testati: un primo modello, alla scala di sistema, si occupa dello studio termico e idraulico dell’intera porzione di cavo testata; il secondo, alla scala di componente, si occupa della simulazione elettromagnetica di un riscaldatore induttivo installato sul conduttore volto a misurarne la stabilità. Il confronto tra l’analisi numerica e quella sperimentale ha permesso la comprensione dei principali fenomeni in gioco e la caratterizzazione del conduttore testato.
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Genoux, Annelise. "Régulation différentielle de la transcription des gènes murin et humain de l'apolipoprotéine A5 en réponse aux cytokines pro-inflammatoires par différents mécanismes impliquant respectivement NF-kB ou COUP-TFI : régulation transcriptionnelle du gène de l'APOA5 par RORα." Lille 2, 2006. http://www.theses.fr/2006LIL2S007.
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L'hypertriglycéridémie, considérée comme un facteur de risque indépendant de maladies cardiovasculaires, est souvent associée à des pathologies métaboliques et inflammatoires. L'apolipoprotéine A5 (APOA5), récemment découverte, exerce un rôle majeur dans l'homéostasie des triglycérides. De ce fait l'étude des facteurs régulant son expression est particulièrement intéressante. La première partie de nos travaux vise à déterminer le rôle de l'APOA5 dans l'inflammation en étudiant la régulation de son expression génique par les cytokines pro-inflammatoires et d'élucider le ou les mécanismes moléculaires impliqués. En utilisant des modèles cellulaires d'hépatomes humain et murin, nous avons initialement démontré que les cytokines pro-inflammatoire IL-1, TNFα et IL-6 régulent de manière opposée l'expression des gènes humain et murin de l'APOA5 in vitro selon différents mécanismes transcriptionnels faisant intervenir notamment les facteurs nucléaires NF-κB p50 et COUP-TFI. Ensuite, des expériences réalisées sur des souris sauvages et transgéniques surexprimant le gène humain de l'APOA5, ont montré que ces cytokines modulent également l'expression des gènes humain et murin de l'APOA5 in vivo. Enfin, la mesure des concentrations en triglycérides, TNFα et apoAV plasmatiques, réalisée chez 32 enfants présentant le syndrome néphrotique idiopathique (11 en rechute et 21 en rémission), a permis de mettre en évidence une corrélation inverse entre la concentration en apoAV et les concentrations en triglycérides et TNFα chez ces patients. Cette observation suggère qu'une inhibition de l'expression du gène de l'APOA5 par le TNFα synthétisé en grande quantité chez ces patients pourrait contribuer à l'hypertriglycéridémie observée. Cette première étude a mis en évidence un nouveau mécanisme impliquant pour lapremière fois COUP-TFI dans la réponse inflammatoire. La deuxième partie de nos travaux a porté sur l'étude de la régulation du gène de l'APOA5 par les facteurs nucléaires ROR. RORα joue un rôle dans le métabolisme des lipide et l'inflammation. Nous avons d'abord démontré que seuls les facteurs RORα1 et RORα4 stimulent fortement l'activité transcriptionnelle du promoteur de l'APOA5 humaine in vitro, en se fixant directement sur un élément de réponse spécifique. Ensuite, l'infection de cellules humaines d'hépatomes par des adénovirus exprimant hRORα1 et hRORα4 a conduit à une augmentation de l'expression des ARNm de l'APOA5. En outre, nous avons montré que le gène murin de l'apoa5 n'est pas régulé par ROR. Cette partie de l'étude identifie un nouveau gène cible de RORα renforçant son rôle dans l'homéostasie des triglycéridesHypertriglyceridemia, considered as an independent risk factor for coronary heart diseases, is often associated with metabolic and inflammatory disorders. The newly identified APOA5 is a crucial determinant of triglyceride levels and therefore the study of the factors regulating its gene expression is of significant importance. The first part of our studies aims at determining the rôle of APOA5 in inflammation by studying the regulation of its gene expression by pro-inflammatory cytokines and elucidate the molecular mechanisms involved. By using hepatic mouse and human cellular models, we initially demonstrated that the pro-inflammatory cytokines IL-1, TNFα and IL66 regulate in an opposite manner the expression of the mouse and human APOA5 genes in vitro, through different transcriptional mechanisms, involving in particular the nuclear factors NF-κB and COUP-TFI. Then, experiments carried out in wild type mice and mice overexpressing human APOA5 showed that cytokines modulate mouse and human APOA5 gene expressions in vivo. Finally, the measurement of plasma triglyceride, TNFα and apoAV in 32 children with an idiopatic nephrotic syndrome ( 11 in relapse and 21 in remission) allowed to establish a negative correlation between apoAV plasma concentration and triglyceride and TNFα concentrations. This observation suggests that the inhibition of the APOA5 gene expression by the high level of TNFα in these patients could contribute to hypertriglyceridemia. This first study identifies a new mechanism involving for the first time COUP6TFI in the inflammatory response. The second part of our studies is focused on the gene regulation study of APOA5 by nuclear factors, ROR. RORα plays a rôle in lipid metabolism and inflammation. We initially demonstrated that only RORα1 and RORα4 strongly stimulate the transcriptional activity of the human APOA5 promoter in vitro through a direct binding on a specific response element. Furthermore, the infection of human hepatic cells with adenovirus expressing hRORα1 and hRORα4 induce an increase of APOA5 mRNA expression. Moreover, we demonstrated that the mouse apoa5 gene is not regulated by ROR. This part of the study identifies a new target gene for RORα strengthening its rôle in triglyceride homeostasis
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Harish, S. "Transcriptional Regulation By Nuclear Receptor Homodimers Binding To The Direct Repeat Motif DR1 : Investigations In An in vitro Transcription System Derived From Rat Liver Nuclear Extracts." Thesis, Indian Institute of Science, 2000. http://hdl.handle.net/2005/164.
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Nuclear receptors (NRs) are important transcription factors involved in the regulation of a variety of physiological processes such as embryonic development, cell differentiation and homeostasis (for review, see Mangelsdorf et al., 1995 TenBaum and Baniahrned, 1997). In contrast to membrane bound receptors, they bind small lipophilic ligands and function in the nucleus as ligand-modulated transcription factors. The ligands for nuclear receptors include steroids (glucocorticoids, progestins, mineralocorticoids, androgens and estrogens), vitamin D3, retinoids, thyroid hormone, prostaglandins, farnesoids etc. Several other nuclear receptors are classified as orphan receptors for which no ligand has yet been identified.
More than 300 nuclear receptors have now been identified and together these proteins comprise the single largest family of metazoan transcription factors, the nuclear receptor superfamily. Recently, a unified nomenclature has been evolved (nuclear receptor nomenclature committee, 1999), a summary of which is presented in Table 1.
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Al-Hasani, Omer Hussain. "Traumatic brain injury with particular reference to diffuse traumatic axonal injury subpopulations." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5569.
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Traumatic brain injury (TBI) remains an important cause of morbidity and mortality within society. TBI may result in both focal and diffuse brain injury. Diffuse traumatic axonal injury (TAI) is an important pathological substrate of TBI, and can be associated with a range of clinical states, ranging from concussion through to death, the clinical severity being associated with a number of factors related to the injury. A retrospective study was conducted using 406 cases with TBI, from the archive of the Academic Department of Pathology (Neuropathology) University of Edinburgh, during the period from1982 and 2005. This cohort was sequential and provided a unique description of the range of pathologies associated with fatal TBI within the Edinburgh catchment area. All the data was collected on a proforma and analysed to provide a description of the incidence in the injury patterns among the Edinburgh cohort. This cohort was then used to provide cases to try and critically assess the mechanisms of axonal injury in TBI. A study was undertaken to investigate TAI in an experimental model of non-impact head injury in a gyrencephalic mammalian model (piglet model) and in human autopsy materials using immunohistochemical analysis of a range of antibodies, and to define the distribution of axonal injury with flow and neurofilament markers in TAI. A further objective was to examine the expression of β-APP as an indicator of impaired axonal transport, three neurofilament markers targeting NF-160, NF-200, and the phosphorylated form of the neurofilament heavy chain (NFH), in different anatomical regions of piglet and human brains. The double immunofluorescence labelling method was then employed to investigate the hypothesis of co-localisation between β-APP and each one of the previous neurofilament markers. The animal studies showed significant differences in NF-160 between sham and injured 3-5 days old piglet cases (6 hour survival) and between 3-5 days sham and injured, when stained with SMI-34 antibody. In 4 weeks old piglet cases (6 hour survival), immunoreactivity of β-APP was significantly higher in injured than control. No other significant differences for any of the antibodies were noted, based on age, velocity, and survival time. Human results suggested that the brainstem had a higher level of β-APP and NF-160 than the corpus callosum and internal capsule. Co-localisation of β-APP with NFs was not a consistent feature of TAI in piglet and human brains, suggesting that markers of impaired axonal transport and neurofilament accumulation are sensitive to TAI, but may highlight different populations involved in the evolution of TAI.
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Boidou, Blaise Noël. "Facteurs d'influence de l'impact d'un usage partagé du tableau blanc interactif sur la performance scolaire dans un établissement d'enseignement secondaire général de Côte-d'Ivoire." Thesis, Cergy-Pontoise, 2019. http://www.theses.fr/2019CERG1003.
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Grâce au numérique, de nombreux dispositifs ont fait leur apparition dans les salles de classe et offrent ainsi la possibilité de multiplier les supports pédagogiques dans le processus d’enseignement/apprentissage. Le Tableau Blanc Interactif ou Tableau Numérique Interactif (TBI/TNI) en fait partie. Aussi, semble-t-il judicieux d’interroger les facteurs qui influencent l’effet d’un tel dispositif sur la performance scolaire, au regard des résultats contradictoires des études scientifiques sur la question.Ce travail de recherche doctorale est une recherche mixte, alliant à la fois des données quantitatives et qualitatives. A la suite de la revue de littérature, elle tente donc de répondre à la problématique suivante : Quels sont les facteurs qui influencent l’impact de l’usage du Tableau Blanc Interactif (TBI) sur la performance des élèves ?Avant la mise en œuvre de la recherche expérimentale, les hypothèses de départ présumaient que dans un processus d’enseignement/apprentissage médié par le TBI, la performance scolaire des élèves est influencée par le style d’apprentissage de l’élève d’une part, et d’autre part, qu’elle est fonction du type de motivation à l’égard du TBI.En vue de confronter ces hypothèses susmentionnées à la réalité du terrain, une procédure expérimentale de type pré-test/post-test, exécutée en deux phases, consistant à une situation d’enseignement/apprentissage sans le TBI et ensuite avec le TBI, a été menée, afin de mesurer la performance scolaire des élèves.Pour recueillir les données, les outils que sont le questionnaire, un test d’identification du style d’apprentissage selon le modèle VAK (Visuel, Auditif, Kinesthésique), les entretiens individuels semi-dirigés, une échelle de motivation et des observations in situ ont été utilisés.Suite à l’analyse des résultats obtenus à partir des alternatives non paramétriques du test de Khi2 et du test t de Student pour des échantillons appariés, des différences significatives sont observées au niveau de la performance des élèves de style d’apprentissage visuel, contrairement aux élèves ayant d’autres styles d’apprentissage majeur.L’impact de l’intervention du TBI dans le processus d’enseignement-apprentissage serait également fonction du genre et de la motivation de l’élève vis-à-vis du TBI. En effet, on constate que les élèves de sexe masculin et les élèves ayant une motivation autodéterminée à l’égard de l’outil technologique ont vu leurs performances augmenter significativementThanks to digital technology, many devices have appeared in classrooms and offer the possibility of multiplying teaching aids in the teaching / learning process. The interactive whiteboard (TBI / TNI) is one of them. Thus, it seems judicious to question the factors that influence the effect of such a device on school performance, given the contradictory results of scientific studies on the subject.This doctoral research work is a mixed research, combining both quantitative and qualitative data. As a result of the literature review, she tries to answer the following question: What are the factors that influence the impact of the use of the Interactive Whiteboard (IWB) on student performance?Prior to the implementation of experimental research, initial assumptions assumed that in an interactive whiteboard-mediated teaching / learning process, students' academic performance is influenced by the student's learning style of learning. on the one hand, and on the other, that it is a function of their degree of motivation with regard to the interactive whiteboard.In order to compare these above-mentioned hypotheses with the reality on the ground, a two-phase experimental procedure consisting of a teaching / learning situation without the interactive whiteboard and then with the interactive whiteboard was conducted in order to measure student academic performance.To collect the data, the tools that are the questionnaire, a test of identification of the learning style according to the model VAK (Visual, Auditory, Kinesthetic), the semi-directed individual interviews, a scale of motivation and observations in situ have been used.Following the analysis of the results obtained from the nonparametric alternatives of the Khi2 test and Student's t test for paired samples, significant differences are observed in the performance of visual learning style students, unlike students with other major learning styles.The impact of the intervention of the whiteboard in the teaching-learning process would also depend on the student's gender and motivation towards the whiteboard. Indeed, we find that male students and students with a self-determined motivation for the technological tool have seen their performance increase significantly
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Ritvo, Paul-Gydéon. "Au coeur du contrôle de l’immunité humorale : (re)définition, mode d’action et répertoire des lymphocytes T folliculaires régulateurs." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCB025/document.
Full textAbstract:
La réponse immunitaire humorale désigne l’ensemble des processus menant à la production d’anticorps suite à une stimulation du système immunitaire. Les lymphocytes T folliculaires régulateurs (Tfr) forment une population essentielle dans le contrôle de l’immunité humorale. Dotés de fonctions régulatrices comme les lymphocytes T régulateurs conventionnels (Treg), les Tfr joueraient un rôle majeur dans les mécanismes de régulation de la production d’anticorps suite à une stimulation. Ils pourraient, par exemple, contrôler l’aide apportée par les lymphocytes T folliculaires helpers (Tfh) aux cellules B leur permettant de se différencier en plasmocytes producteurs d’anticorps dans une structure hautement spécialisée appelée centre germinatif (CG). Suite au constat de la non-réponse des Tfr à l’interleukine (IL)-2, nous avons observé l’absence d’expression de la sous-unité du récepteur à l’IL-2 (CD25) sur ces cellules et ainsi donné de nouvelles bases à la caractérisation phénotypique des Tfr. Cette redéfinition restrictive de la population cellulaire a permis une description plus approfondie de ces cellules et la découverte d’un axe de régulation du CG dépendant de l’IL-1ß. La dualité de régulations observée entre d’une part l’axe Treg - lymphocytes T effecteurs contrôlé par l’IL-2 en dehors du CG et d’autre part l’axe Tfr - Tfh contrôlé par l’IL-1ß dans le CG nous a amenés à nous poser la question de l’origine et de la spécificité des Tfr en partie élucidée par une analyse du répertoire de ces populations. Nous avons mis en évidence une similarité en matière de distribution et caractéristiques globales des répertoires des cellules folliculaires qu’elles soient régulatrices (Tfr) ou non (Tfh). Il est également apparu une proximité de spécificités entre le répertoire des Treg et des Tfr confortant l’hypothèse d’une origine commune de ces deux populations. Ce travail de thèse a permis la découverte d’éléments importants de la biologie des Tfr, population impliquée dans le contrôle des régulations humorales. Il ouvre des perspectives relatives au contrôle de la production d’anticorps tant sa limitation - dans le contexte de maladies auto-immunes - que son exploitation dans le développement de stratégies vaccinalesThe immune humoral response offers the organism an efficient protection through the production of antibodies following an immune stimulation. Follicular regulatory T cell (Tfr) is an essential subset in the control of humoral immunity. These cells share with conventional regulatory T (Treg) cells regulatory functions and should play a major role in the control of antibody production following stimulation. As T follicular helper (Tfh) cells help is essential in the differentiation of B cell into antibody-producing plasma cells, one of the possible mechanisms of Tfr’s control could be the limitation of the Tfh cells’ help to the B cells. As a consequence of the non-response of Tfr cells to interleukin (IL)-2, we thoroughly revealed the CD25- phenotype of Tfr cells thus redefining the subset. This stringently-selected population allowed a fine-tuned characterization of Tfr cells and the discovery of an IL-1β axis regulating the germinal center responses. The dual regulation of T cells in secondary lymphoid organs, one between Treg and Teff cells regulated by IL-2 outside germinal centers and the other between Tfh and Tfr cells regulated by IL-1 inside GCs brought us to question the origin and specificity of Tfr cells. We partially answered this with a high-resolution analysis of these populations’ repertoires. We highlighted a similarity in the distributions and global characteristics of the follicular cells’ repertoires regardless their regulatory (Tfr) or not (Tfh) phenotype. We also brought out the major sharing between Treg and Tfr repertoires underpinning the hypothesis of a common origin for these populations. This work has disclosed important aspects of Tfr cells’ biology, a fundamental subset in the control of humoral immune responses. It opens many perspectives including the control of antibody production, negatively in the context of autoimmune diseases or its positive exploitation to enhance vaccine efficacy
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Abreu, Renata Cardoso Pires de. "Ensaio da Ferramenta DIA Diagnóstico e Informação do aluno." Universidade do Estado do Rio de Janeiro, 2012. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=4751.
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Weve presented the results of our research for the conception, execution and
evaluation of an informatized adaptive tool, known as DIA (in portuguese), that allows
evaluate and give a feedback to the student under the perspective of formative evaluation. At
the first stage, we used the PCN: Sciency of the Nature, Mathematics and its Technologies
(BRASIL, 1998) and the Curriculum Matrices of Reference from the Instituto Nacional de
Estudos e Pesquisas Educacionais -INEP, to the Sistem of Evaluation for Basic Education -
SAEB (BRASIL, 2005) to build a scale in wich the objectives are in increasing order,
according to the vertical development of the knowledge construction in Mathematics. We
linked the proposed objectives to create a Data Bank (BI, in portuguese) that was used in our
simulations. Weve analized the results of our essay to evaluate the comunication between the
data bank and the scale under the perspective of giving a diagnosis of the construction of the
mathematics knowledge. In our essay, we simulated the functionning of the DIA tool through
an adaptive informatized test based on the "Teoria de Resposta ao Item" (TRI). We were also
interested on determing a profile of a Data Bank (BI) that is able to significantly dialogue
with our scale through the TRI. The scale and the associated data bank should provide a
constructive feedback that will help the stundents develop their metacognitives competencies.Apresentamos os resultados de nossa pesquisa para concepção, execuçãoo e avaliação de uma ferramenta adaptativa informatizada, denominada DIA, que permita tanto avaliar como fornecer feedback a estudantes sob uma perspectiva de avaliação formativa. Na primeira etapa, usamos os PCN: Ciências da Natureza, Matemática e suas Tecnologias (BRASIL, 1998) e as Matrizes Curriculares de Referência do Instituto Nacional de Estudos e Pesquisas Educacionais - INEP, para o Sistema de Avaliação para a Educação Básica- SAEB (BRASIL, 2005), para construir uma escala, em que os objetivos estão em ordem crescente, de acordo com o desenvolvimento vertical da construção do conhecimento em Matemática. Entrelaçamos os objetivos propostos para criar um Banco de Itens (BI), que foi usado em nossas simulações. Analisamos os resultados obtidos em nosso ensaio para avaliar o diálogo entre o BI e a escala sob a perspectiva de oferecer um diagnóstico de lacunas na construção do conhecimento matemático. Em nosso ensaio, simulamos o funcionamento da ferramenta DIA através de um teste adaptativo informatizado baseado na Teoria de Resposta ao Item (TRI). Também estamos interessados em determinar um perfil de um Banco de Itens, que seja capaz de forma significativa de dialogar com nossa escala através de TRI. A escala e o banco de itens a ela associado devem viabilizar um feedback construtivo que ajude os alunos a desenvolverem competências metacognitivas.
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Wheeler, Marissa Pearle, and Marissa Pearle Wheeler. "Tri Tri Again: The Physiology of Triathlon." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/625240.
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The cardiovascular system plays an essential role in any endurance event. The Ironman Triathlon is a long distance event that is made up of a 2.4 mile swim, a 112 mile bike, and a 26.2 mile run for a total of 140.6 miles. Each segment of an Ironman Triathlon poses unique challenges to the cardiovascular system. In order to complete such a monstrous race cardiovascular adaptations occur during the chronic stress of training, and the body also makes acute adaptations during the metabolic stress of the race itself. These alterations of the heart, blood vessels, and the blood make the body more efficient at transporting oxygen and nutrients to the muscles via the circulatory system, at extracting oxygen and nutrients from red blood cells and into the tissues, and at maintaining homeostasis. The results of these changes are higher maximum heart rate, increased oxygen extraction, higher capillary bed density, higher mitochondrial density, increased VO2 max, increased cardiac output, better thermoregulation, and non-pathological hypertrophy of the heart. While an excessive amount of long-term vigorous endurance activity can have adverse impacts on the cardiovascular system, the body is surprisingly capable of racing such a long distance with the proper training adaptations.
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Patel, Kaushal S. "Post-TBI Hippocampal Neurogenesis in Different TBI Models." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4134.
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Traumatic brain injury (TBI) leads to short-term and long-term consequences that can cause many different life-long disorders. Studies of TBI have generally focused on the acute stage; however, it is now becoming important to investigate chronic responses following TBI as clinical reports of dementia and cognitive impairments have been linked to a history of TBI. Recent data have established that cognitive function is associated with hippocampal neurogenesis. Chronic injury induced changes in the brain may affect this endogenous process. Chronic responses following TBI include cell death pathways and inflammatory responses that are persistent in the brain for months to years after injury. In this study we investigate the chronic consequences of TBI on adult neurogenesis and the possible involvement of chronic-inflammation in regulating adult neurogenesis. We used two popular TBI animal models, Control Cortical Impact (CCI) and Lateral Fluid Percussion Injury (LFPI) models, to examine focal and diffuse injury responses respectively. Adult rats received CCI, LFPI, or sham injury and were sacrificed at either 15 days or 3 months after injury to examine either subacute or chronic TBI-induced responses respectively. We found no change in levels of proliferation activity at both time points in both TBI models compared to sham animals. Using Doublecortin immunolabeling we found an enhanced generation of new neurons at 15 days after injury and by 3 months this activity was significantly reduced in both TBI models compared to sham animals. We also found persistent inflammation in the injured brains at both time points. Morphological assessment showed that LFPI model of TBI causes shrinkage of the ipsilateral hippocampus. Our results show that moderate TBI induced hippocampal neurogenesis in both models at the early time post-injury. However, at chronic stage, reduced hippocampal neurogenesis is observed in both models and this is accompanied by chronic inflammation. These results suggest that persistent inflammatory responses maybe detrimental to normal neurogenic activity, leading to cognitive impairment and neurodegeneration in long-term TBI survivors.
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Te, Kanawa Kahutoi Mere. "Toi Maramatanga." AUT University, 2009. http://hdl.handle.net/10292/883.
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The focus of this thesis is to visually show the significance and relationship between the use of natural materials, and geometric patterns used in Māori weaving. The patterns will reflect indigenous episteme of artistic and tacit knowledge. These patterns are significant to the Māori worldview of kaitiakitanga (stewardship of knowledge), which is cognisant in the ontology of Māori weaving. These patterns are significant forms of Māori cultural symbols that reflect elements of nature, evolution of time and space. The focus is to show how natural materials can be utilised in an art form that embraces bicultural activity, as a reference to customary and new age methods of thinking and practice. This leads to self-enquiry and our own responsibilities, only to ask ourselves; What are the guiding principles within art and design, that upholds the core values of Mātauranga Māori? (Māori epistemological thinking). The concept of this thesis is to define the cultural significance of kaitiakitanga (stewardship), through the preservation of Mātauranga Māori and practice as weavers and artists. This concept challenges our own understanding of what we know and what we don’t know about the relationships between people, place, environment and use. The methods and processes used for this work will be based on customary practices and methods, using native materials, endemic to New Zealand. These materials will be harvested at different time periods. The methodologies used in this project, is a product of intrinsic knowledge and testing new boundaries, through researching more specific detail about varieties of harakeke (New Zealand flax) cultivars, testing the flexibility, functionality and durability of materials. This will challenge the test, of making sure that the methods used will be significantly practiced throughout the processes involved in the making of artistic pieces of work, in accordance to tikanga (protocols). The use of native materials enhances cultural values of kaitiakitanga as a metaphor, which asserts sustainability of Māori epistemological notions of practice and meaning.This also applies to the visual language of Māori. The concept of visual language embraces metaphoric meanings and understanding, which relates to our co-existence with the earth, animals and the elements. All these elements of nature are contained within symbolic traditional patterns. Some of these patterns have derived from phenomena of thought structure, historical events and our co-existence through our connectedness to the land, waters, oceans, sky and universe. How can Māori forms of art be embraced and imbued, in modern society, that signifies place, belonging and cultural enhancement?
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Aydin, Céline. "La conception de ressources de turc langue étrangère pour le TBI/TNI et l'EAD : apports de la théorie des conflits instrumentaux à l'approche actionnelle." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAG023.
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Cette recherche, débutée en 2013 au sein de l’Institut Yunus Emre visait à créer une plateforme utilisable sur le tableau blanc interactif (TBI) pour l’enseignement du turc à distance ainsi que pour l’enseignement présentiel et à faire une évaluation du ressenti positif ou négatif des apprenants et des enseignants l’ayant utilisée. Lors de la réalisation concrète, deux projets différents ont été mis en place pour l’enseignement à distance et l’enseignement présentiel et nous rendons compte ici du projet de création d’un manuel électronique pouvant étre utilisé sur le TBI en cours présentiels. Le résultat le plus marquant de notre enquête auprès des enseignants est le ressenti des enseignants ayant reçu une formation de TICE et ayant plus de trois ans d’expérience professionnelle. Une différence a été constatée dans le caractère suffisant des informations données en début de chaque unité, l’utilisation du manuel électronique au lieu du manuel classique, la réalisation de travaux de compréhension écrite et orale ou encore l’utilisation de matériels audios pendant le cours. Pour ce qui concerne les apprenants, nous n’observons que très peu de différences aux niveaux pédagogiques, didactiques et techniques. Nous notons seulement que les apprenants kosovars ont davantage apprécié le manuel que les apprenants des autres pays. Les apprenants âgés entre 15 et 22 ans trouvent le manuel électronique plus dynamique et attractif visuellement que les apprenants des autres tranches d’âge. Ils préfèrent également utiliser ce manuel en dehors de la classeSummary Started in 2013 at the Yunus Emre Institute, the objective of this research was to create a set of pedagogical resources to be used with an interactive whiteboard (IW), for ODL, as well as for in class teaching of Turkish language, and to evaluate positive and negative impressions of both users learner and teacher. During the concrete realisation of this platform, the work has finally been split into two different projects, one for ODL and one for face-to-face teaching. We are presenting here the different phases of the design of an electronic handbook to be used with an IW in face-to-face teaching situations. The most significant results concern the feedback from teachers who have been trained in using ICT and who have been teaching Turkish for more than three years. A difference has been highlighted about the quality of data given at the beginning of each training session, the interest of the use of the electronical handbook instead of a paper textbook, the completion of written and oral comprehension exercises and the exploitation of audio materials during class. As for the students, few disparities were noticed along the different initial pedagogical, didactic and technical levels. Nevertheless it has to be pointed out that the Kosovar students appreciated the manual more than the students from other countries and that students, aged between 15 and 22 years old, found the electronical handbook more dynamic and visually attractive than the students from other age categories. They also prefer using this manual outside the classroom
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Morey, Stephen. "The Tai languages of Assam : a grammar and texts." Monash University, School of Languages, Cultures and Linguistics, 2002. http://arrow.monash.edu.au/hdl/1959.1/8732.
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Grajciar, Marek. "Tri podoby Solarisu." Master's thesis, Akademie múzických umění v Praze.Filmová a televizní fakulta. Knihovna, 2016. http://www.nusl.cz/ntk/nusl-264782.
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Diploma thesis deals with three forms of Solaris. Specifically with novel by Stanislaw Lem, a film adaptation of Andrei Tarkovsky and the second film adaptation of Steven Soderbergh. The aim of this work is comparison of individual authors practices that led to different semantic tone. Thesis analyzes six basic aspects of individual works: basis, genre, semantic structure, syntactic structure - a dramatic structure, characters and space-time.
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Law, Ka-ping. "The effects of Tai Chi on balance, affects, subjective well-being, perceived health status, and self-efficiacy of people with severe mental illness /." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B3678588X.
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Yang, Yuh-Ming. "Le toi et le toi absolu dans la philosophie de gabriel marcel." Paris 4, 1986. http://www.theses.fr/1986PA040140.
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L'homme se perd dans le monde des objets, et c'est a partir de son corps pris comme l'existant-type qu'il se retrouve et decouvre en meme temps que l'autre est comme le moi un sujet. Il ne s'agit pas d'une coexistence de sujets, mais de la creation d'une relation inter-subjective entre des etres. La rencontre et le le dialogue sont les moteurs d'une telle relation ; ils permettent de briser la coquille egocentrique ou le moi s'enferme et devient pour lui-meme un objet. Le moi des lors s'engage sur le chemin de l'etre. Le moi brise a besoin d'un toi pour etre vraiment, au sens marcelien de ce terme, c'est-a-dire un co-esse. L'amour et la fidelite alimentent la relation inter-subjective dans la presence et l'entiere disponibilite. Chez un etre fini, l'amour et la fidelite sont soumis a l'obstacle et conduits a l'echec, ils demandent un recours ultime qui ne peut venir de la volonte humaine creee, mais du toi absolu. C'est uniquement dans la priere et dans la foi que le rapport d'etre a etre est garanti. Et c7est ici, que la formule : j'espere en toi pour nous, prend tout son sens. Par cette voie gabriel marcel parvient a sauvegarder le mystere de l'etreMan is lost in the world of objects, and from his body he find and discover himself in the same time as the other is, like the ego, a subject. It doesn't mean that it is a coexistence of subjects, but the creation of an inter-subjective relation between beings. The reception and the dialogue are the motors of such relation; they permit to break the egocentric schell where the ego is enclosed and become for himself an object. The ego at that moment is engaged on the way of the being. The brocken ego needs the thou to be really, in the marcellian thought, it means an co-esse. Love and fidelity feed the inter-subjective relation in the presence and complete disponibility. For a finished being, love and fidelity are under the effect of obstacles and conduct to failure they need an ultime refuge that cannot come by the creating human will, but from the absolute thou. It's only by prayer and faith that the relation from being to being is sure. And here the sentence : i hope on thee for us, take all its meaning. And by this way gabriel marcel arrive to keep safe the mystery of being
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Clavier, Eric. "Etude des strategies de tri : application a un systeme de tri formulaires." Caen, 2000. http://www.theses.fr/2000CAEN2082.
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S'inscrivant dans le domaine de la reconnaissance de formes, cette these traite plus particulierement du tri de formulaires. L'application cible consiste a identifier au sein d'un flux de documents ceux qui correspondent a des types connus du systeme. Il s'agit donc d'une part de reconnaitre les documents appris et d'autre part de rejeter les documents non appris. L'etude des techniques de reconnaissance de forme nous conduit dans un premier temps a faire une distinction entre classification et tri. La specificite du tri est due a l'apparition implicite de formes n'appartenant pas a une classe connue et devant donc etre rejetees. Ceci nous amene a redefinir les criteres d'evaluation des performances d'un systeme de tri. Par la suite, nous decrivons plus precisement l'application de traitement des courriers d'un organisme de gestion des prestations familiales. En tenant compte des contraintes du systeme, nous proposons differentes realisations d'un module de tri. Chacune des solutions considere que le tri peut etre decompose en une phase de classement suivie d'une phase de validation. Neanmoins elles different par les informations utilisees a chacune des etapes. Ainsi, certaines des solutions envisagees utilisent les memes informations pour le classement et le rejet alors que d'autres utilisent des metriques ou des informations differentes. Ensuite, au vu des resultats obtenus par les differentes solutions, nous nous orientons vers une realisation basee sur la combinaison de classifieurs. Neanmoins, l'etude des methodes de combinaison nous conduit a les adapter au probleme du tri, notamment dans la gestion du rejet. Nous completons cette etude en presentant quelques resultats d'une experience de suivi du regard relative a des sujets humains en situation de tri de formulaires. L'etude des donnees oculometriques nous permet d'apprehender la nature des informations capturees lors de l'apprentissage et la reconnaissance des images.
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Yang, Yuh-Ming. "Le Toi et le Toi Absolu dans la philosophie de Gabriel Marcel." Lille 3 : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb37601887q.
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林國儀 and Kok-ie Liem. "Redevelopment of Tai O." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1994. http://hub.hku.hk/bib/B31982098.
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林康祺 and Hong-ki Connie Lam. "Transformation of Tai O." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B31985798.
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Lu, Qingyi. "Halogenolyses of tri-alkylborane /." Online version of thesis, 1990. http://hdl.handle.net/1850/11071.
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Liem, Kok-ie. "Redevelopment of Tai O." Hong Kong : University of Hong Kong, 1994. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25944897.
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Lam, Hong-ki Connie. "Transformation of Tai O." Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25950058.
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Fagelson, Marc A. "Taming TBI-Associated Tinnitus." Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/etsu-works/1594.
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Regardless of the tinnitus sound (itself), tinnitus can be especially challenging for clients when paired with traumatic brain injury and post-traumatic stress. Research offers insight into how clinicians can help clients manage this co-occurrence.
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Walker, Tim. "Robley Te Ropere, 1840-1930 /." Wellington, N.Z. : New Zealand Electronic Text Centre, 2007. http://www.nzetc.org/tm/scholarly/tei-WalRobl.html.
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Thesis (M.A.--Art History)--University of Auckland.Title from title screen (viewed on 18 June 2009). Creation of machine-readable version: Aptara. Conversion to TEI.2-conformant markup: Samantha Callaghan. Creation of digital images: Aptara.
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Buck, Peter Henry. "Medicine amongst the Maoris in ancient and modern times a thesis for the degree of Doctor of Medicine (N.Z.) /." Wellington, N.Z. : New Zealand Electronic Text Centre, 2007. http://www.nzetc.org/tm/scholarly/tei-CouNouv.html.
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Thesis (Ph. D.)--University of New Zealand, 1910."Abound" is the pseudonym of Sir Peter Buck. Photocopied material. Title from title screen (viewed on 19 June 2009). Creation of machine-readable version: Planman Technologies. Conversion to TEI.2-conformant markup: Planman Technologies. Creation of digital images: Planman Technologies. Originally published in print: University of New Zealand, 1910.
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Tran, Thi Duyen. "An exploratory study of the current assessment practices for improving the learning of English as a foreign language (EFL) in two Vietnamese universities." Thesis, Queensland University of Technology, 2015. https://eprints.qut.edu.au/84622/1/Thi%20Duyen_Tran_Thesis.pdf.
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This case study investigated EFL assessment practices at one public and one private university to explore the support of assessment for English language learning (ELL) within the Vietnamese sociocultural context. Findings demonstrated the potential of assessment to engage students in learning; enhance their understanding of the learning objectives; and facilitate their learning reflection. Findings also identified strong influences of contextual factors such as teachers' language assessment literacy, high-stakes testing and institutional administrative policies on the practices of assessment for ELL. This study contributes to research on Assessment for Learning and EFL education at tertiary level in Vietnam and other similar sociocultural contexts.
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Truong, Thi Hue. "Vietnamese nursing students' perceptions of their clinical learning environment: A cross-sectional survey." Thesis, Queensland University of Technology, 2015. https://eprints.qut.edu.au/91390/1/Thi%20Hue_Truong_Thesis.pdf.
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This study investigated Vietnamese nursing students' perceptions of their clinical learning environment. The study was undertaken in two phases: 1) translation and adaptation of research instrument and 2) a cross-sectional survey was followed. Despite validity issues identified, data from two valid sub-scales and structured questions provided insights into the clinical learning environment that is the environment did not operate from an adult learner philosophy or provide a student-centred environment. The results are significant for development of clinical learning environment in Vietnam and that cultural differences between populations should be carefully considered in future research.
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Ho, Thi Nhat. "An exploratory investigation of the practice of assessment for learning in Vietnamese higher education: Three case studies of lecturers' practice." Thesis, Queensland University of Technology, 2015. https://eprints.qut.edu.au/91545/1/Thi%20Nhat_Ho_Thesis.pdf.
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In response to limited research conducted on the practice of assessment for learning (AfL) in higher education and in Asian educational settings, this qualitative study, using sociocultural theories of learning and a multiple case study approach, investigates how AfL was implemented by three lecturers in one Vietnamese university. Findings revealed that the lecturers engaged with AfL principles and practices to some extent. However, despite the lecturers' significant efforts, Vietnamese sociocultural factors such as respect for harmony, hierarchy, and examination-oriented learning, impacted on their practice of AfL. This study therefore argues that AfL requires adaptation for it to be effective in the Vietnamese tertiary context.
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Sunarharum, Tri Mulyani. "Collaborative planning for disaster resilience: the role of community engagement for flood risk management." Thesis, Queensland University of Technology, 2016. https://eprints.qut.edu.au/101560/1/Tri%20Mulyani_Sunarharum_Thesis.pdf.
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Rapid urbanisation, fragmented governance and recurrent flooding complicates resolution of DKI Jakarta’s chronic housing shortage. The purpose of this thesis is to re-frame planning decision-making through collaborative approach to address risks of flooding and to increase community resilience. This thesis found that in spite of strong policy frameworks underlying flood risk management strategies, there are opportunities for improvement of collaboration mechanisms in decision-making processes and in implementation of plans to strengthen disaster resilience. It also potentially widens participation in dialogues regarding the effectiveness of policies and plans for flood risk management in Indonesia and across equatorial mega-cities facing similar challenges.
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Nguyen, Thi Hang. "Accounting and accountability for anti-bribery: Evidence from a developing country." Thesis, Queensland University of Technology, 2016. https://eprints.qut.edu.au/102233/1/Thi%20Hang_Nguyen_Thesis.pdf.
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This thesis is a study of accounting and accountability for anti-bribery in a developing country. It examines how accounting is used for controlling or facilitating bribery by a foreign company doing business in Vietnam, how stakeholders play the roles in fighting against bribery, and what accountability measures have been taken in that fight.
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Nguyen, Thi Nguyet. "Self-management program for people with chronic kidney disease in Vietnam: A pragmatic randomised controlled trial." Thesis, Queensland University of Technology, 2018. https://eprints.qut.edu.au/119220/1/Thi%20Nguyet_Nguyen_Thesis.pdf.
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Chronic kidney disease is a growing health problem worldwide. This thesis reports a three-phase study which translated and tested instruments into Vietnamese language followed by a pragmatic randomised controlled trial of a self-management program for people with chronic kidney disease. This study found that the program was a simple and effective way to improve a person's understanding of kidney disease, and to give them confidence and self-management skills to manage the disease as well as improving quality of life. Importantly for healthcare clinicians in Vietnam, the study provides strategies to better support people with earlier stages of this disease.
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Nguyen, Thi Phuong Lan. "Foot self-care among patients with diabetes in Vietnam: The effectiveness of an education program to fill the self-care gap." Thesis, Queensland University of Technology, 2019. https://eprints.qut.edu.au/134465/1/Thi%20Phuong_Nguyen_Thesis.pdf.
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This research investigated the effectiveness of a Self-efficacy theory-based foot care education intervention program (3STEPFUN) for Vietnamese patients with diabetes at low risk of developing foot ulceration. A quasi-experimental study was conducted to determine if the intervention improved participants' foot self-care behaviour and foot risk factors for ulceration. The results showed that the 3STEPFUN has potential to prevent minor foot problems which commonly precede diabetic foot ulcers. The research provides important contributions to the current evidence base on diabetic foot ulcer primary prevention in a field where the application of theory-based nurse-administered programs is still limited.
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Nguyen, Thi Vinh. "Women with physical disabilities in Northern Vietnam: The lived experiences of pregnancy, childbirth, and maternal healthcare." Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/207988/1/Thi%20Vinh_Nguyen_Thesis.pdf.
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This thesis examines how Northern Vietnamese women with physical disabilities experienced pregnancy, childbirth, and maternal healthcare. A critical interpretative phenomenological approach and intersectional lens were utilised to understand the complexity of their experiences. The women demanded the right to pregnancy and motherhood, however, they encountered multiple challenges associated with powerful socio-cultural beliefs that intersected with gender, disability, and motherhood identities. This nexus produced and contributed to stigma, discrimination, poverty, and inaccessible environments. The findings emphasise the need for their lived experiences to shape the development and evaluation of maternal healthcare policies, programs, training, and services that impact their lives and well-being
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Jatko, Emil. "Påverkar personlighetsdrag risken att utveckla demens?" Thesis, Umeå universitet, Institutionen för psykologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-143380.
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Syftet med denna uppsats är att undersöka om olika personlighetsdrag kan relateras till risk för att utveckla en demenssjukdom. Studien har baserats på data från en longitudinellt populationsbaserad studie och totalt har 445 personer, i åldern 60 år och äldre, deltagit. Under studiens uppföljningstid diagnostiserades 67 deltagare med en demenssjukdom. Cox regressionsanalys användes för att undersöka ett eventuellt samband mellan personlighet och demens och ett flertal potentiella kovariater inkluderades i analyserna. Resultaten visade ett signifikant samband mellan personlighetsdraget Harm Avoidance (HA) och demens. Sambandet mellan HA och demens kvarstod även efter att samtliga kovariater inkluderats i analyserna. Resultatet tyder på att vissa personlighetsdrag kan öka risken för att utveckla demens men resultaten ska dock ses som preliminära då det är baserat på ett relativt litet sampel.The aim of this study is to examine if different personality traits can be related to the risk of developing dementia. This study was based on data from a longitudinal population based research project, and includes a sample of 445 people aged 60 years and over. During the course of the study, 67 participants were diagnosed with dementia. Cox regression analysis was used to investigate a possible relationship between personality and dementia. A number of potential covariates were included in the analysis. The results showed a significant relationship between the personality trait Harm Avoidance (HA) and dementia. The relationship between HA and dementia remained after controlling for a range of possible covariates. The result from this study suggests that some personality traits may be associated with increased risk of developing dementia. However, the results from this study should be interpreted with caution due to the relatively small sample size.
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Leendertz, Fabian H. "Krankheiten bei wildlebenden Schimpansen im Taï-Nationalpark, Côte d'Ivoire /." Berlin : Mensch-und-Buch-Verl, 2005. http://www.diss.fu-berlin.de/2006/130/index.html.
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Fischer, Elke. "Einfluss der Landnutzung auf den Nährstoffhaushalt im Teileinzugsgebiet des Hana an der Grenze des Taï-Nationalparks (Côte d'Ivoire) ein Vergleich zwischen Wald und Kakaoplantagen /." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=973941936.
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Lissoir, Marie-Pierre. "Le khap tai dam, catégorisation et modèles musicaux. Étude ethnomusicologique chez les Tai des hauts plateaux du Laos." Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCA061.
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Cette thèse étudie le chant khap de l’ethnie des Tai Dam du Laos à partir de la notion de modèle musical. Abordé au travers du concept de la pertinence, son principal objectif est la mise en lumière des compétences liées au chant, c’est-à-dire des connaissances abstraites nécessaires à l’interprétation et la catégorisation du chant. Fil rouge de ce travail, c’est au départ de la notion de modèle que sont construits les différents chapitres. Partant d’une considération d’ordre musical, sont mis au jour les mécanismes de transmission du chant, les rapports entre tons parlés et chantés, ainsi que les différents mécanismes de catégorisation musicale et identitaire. La thèse montre l’imbrication de chacun de ces aspects et la pertinence de la mobilisation de plusieurs disciplines dans la réalisation de cette recherche : musicologie, anthropologie et linguistique. C’est dans une perspective intégrant les points de vue étiques et émiques et par le développement d’une méthodologie adaptée aux particularités du sujet que sont discutés les différents axes de la rechercheThis research studies the singing named khap of Tai Dam ethnic group in Laos, through the notion of musical model. Its main objective, approached with the concept of relevance, is the highlight of the competences linked to the singing, that is to say the abstract knowledge needed for the interpretation and the categorisation of the singing. The principle of musical model is the common theme of this research, and is the starting point of every chapter. Starting from musical considerations, the PhD highlights the mechanisms of musical transmission, the relationships between spoken and musical tones, as well as the different mechanisms of musical categorisation and identity categorisation. This work shows the interweaving of every of those aspects and the relevance of using different disciplines: musicology, anthropology and linguistic. The different lines of this work are approached with a perspective mobilising etic and emic perspectives and by the development of a methodology adapted to the specificities of the topic
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Borghese, Domenica. "A prática do Tai-Chi como nova fronteira terapêutica da fisioterapia na melhoria da capacidade funcional do idoso: uma revisão bibliográfica." Bachelor's thesis, [s.n.], 2016. http://hdl.handle.net/10284/5668.
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Projeto de Graduação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Licenciada em FisioterapiaIntrodução: No idoso, a capacidade física e funcional vai sofrendo um declínio/mutações físicas e mentais, levando à perda gradual da independência e a uma diminuição da qualidade de vida. O Tai-Chi sendo um tipo de exercício suave e lento, caracterizado por movimentos harmoniosos e graduais, em que a intensidade pode ser regulada pelas exigências específicas de cada individuo, é considerado como uma atividade adequada a todas as idades e benéfica na prevenção do declínio dos sistemas mais atingidos no envelhecimento, bem como o sistema vestibular, visual e somatosensorial. Objetivo: Analisar os efeitos terapêuticos do Tai-Chi no desempenho funcional do idoso e constatar como a prática desta disciplina pode ser utilizada como técnica complementar em Fisioterapia. Metodologia: Pesquisa computorizada na base de dados PubMed, e PEDro, para identificar estudos que relativos aos benefícios ligados a prática de Tai-Chi no idoso. A classificação de todos os artigos foi pesquisada através da plataforma e escala de PEDro, analisando cada critério. Resultados: Foram selecionados 8 artigos, com um total de 2.276 participantes com idades superiores a 60 anos, obtendo uma média de 4.25 na escala de PEDro. Os resultados dos diversos estudos demonstraram como a prática de diferentes estilos de Tai- Chi pelos idosos pode melhorar significativamente as suas ações motoras. Conclusão: A prática do Tai- Chi leva a um aumento da estabilidade postural, melhoria do controlo de equilíbrio, proprioceção, e qualidade da marcha do idoso, capacidades determinantes na diminuição das quedas prejudiciais deste. Sugere-se, de futuro, a realização de mais estudos experimentais que reforcem estas evidências, tanto na ação preventiva como na ação terapêutica do Tai-chi no idoso.
Introduction: In the elderly, physical and functional capacity will suffer a decline / physical and mental changes, leading to the gradual loss of independence and a decreased quality of life. Tai Chi is a type of soft and slow exercise, characterized by smooth and gradual movements, in which the intensity may be governed by the specific requirements of each individual, is considered as an appropriate activity for all ages and beneficent in preventing the decline of the most affected systems during aging , as well as the vestibular system, visual and somatosensory. Objective: analyze the therapeutic effects of Tai Chi on functional performance in elderly and see how the practice of this discipline can be used as a complementary technique in physiotherapy. Methodology: computerized search in PubMed database, and PEDro to identify studies on the benefits linked to the practice of Tai-Chi in the elderly. Classification of all articles was screened by the platform and PEDro scale, analyzing each criteria. Results: 8 articles were selected, with a total of 2,276 participants aged over 60 years, reaching an average of 4.25 on a scale of PEDro. The results of several studies demonstrated how the practice of different styles of Tai Chi by the elderly can significantly improve their motor actions. Conclusion: The practice of Tai Chi leads to increased postural stability, improve equilibration control, proprioception, and elderly gait quality, determinants capacities in reducing damaging declines of this. It is suggested that, in future, the realization of more experimental studies that reinforce this evidence, in preventive action and in therapeutic action of Tai-chi in the elderly.