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Alsouyid, Hajer Mohammed, Nuria Ali Elamri, Haifa Mohamed Duzan, Abdunabi Mohamed Abughania, and Ammar Khalifa Aslougi. "Molecular characterization of lternaria solani isolates on tomato plant Lycopersicum esculentum Mill." Journal of Misurata University for Agricultural Sciences, no. 01 (October 6, 2019): 379–400. http://dx.doi.org/10.36602/jmuas.2019.v01.01.29.
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Early blight disease causes severe damage to the foliar part of solanaceous crops including tomato. Fifteen isolates (12 from tomato, 2 from potato, 1 from pepper) were collected from different sources in Tripoli. Field and laboratory studies were conducted to determine cultural behaviour on PDA medium, morphological, pathogenic and molecular variation between isolates tested. Colonies of isolates revealed variation in their cultural behaviour on PDA medium ranging from cottony to appressed growth, with colour ranging between light to dark olivaceous. The pigments released by the isolates changed the medium colour to grey or brown. Morphological studies of the fungal isolates exhibited short conidiophores bearing a single or chains of paired conidia. This study revealed a significant variation in conidial size for the isolates tested ranging from 23.45 to 46.90 x 7.70 to 14.00 µm. Pathogenicity testes on fruits, plants, and detached leaves of tomato indicated a high significant variation between isolates tested ranging from highly to moderate or weak pathogenic. Genetic diversity of A. solani isolates using RAPD-PCR with oligonuclotide primers revealed significant differences in the appearance of polymorphic and monomorphic banding patterns. Three primers (OPA-07, OPA-09, OPJ-09) out of ten were able to determine the genetic fingerprints of tested isolates. Cluster analysis of RAPD-PCR products showed that primer OPA-07 was able to classify the isolates into five groups: group A (TF4,TF7, TL1, TL3), group B (TF1,TF3, TF8, PEF), group C (TF5, TF6, TF9, POL1, POL2), whereas the remaining two isolates TL2 and TF2 were unique in their patterns and were designated as group U1 and U2 respectively. Primer OPA-09 revealed four distinct genetic groups designated as: group A (TF4, TF6, TF7, TF8, TL2), group B (POL1, TL3, TF3), group C (TF5, POL2) and group D (TL1, TF1, TF2, TF9, PEF). However primer OPJ-09 was able to split the isolates tested into four distinct clusters: group A (TF1, TF7, TL3, PEF), group B (TF3, TF8, POL2), group C (TF2, TF6, TF9, TL2) and group D (TF4, TF5). The results of RAPD-PCR demonstrate existence of considerable variation in molecular characteristics of A. solan iisolates. Accordingly these isolates were classified into different groups and unique patterns with no obvious association between the pattern of clustering of the isolates and their host of origin, morphological characteristics and pathogenicity.
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Coulom, Fierre, and Fernand Vicari. "TFI." Acta Endoscopica 35, no. 3 (June 2005): N10. http://dx.doi.org/10.1007/bf03003316.
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García Rosales, Liliana, Virginia Moreno Juvinao, and Jaider Andrés Pushaina González. "Severidad de la fluorosis dental en siete instituciones de salud de Barranquilla (Colombia) durante el período enero de 2013 - junio de 2014." Acta Odontológica Colombiana 9, no. 2 (July 1, 2019): 36–46. http://dx.doi.org/10.15446/aoc.v9n2.76793.
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Objetivo: el presente estudio se propone identificar la severidad de la fluorosis en siete instituciones de salud de Barranquilla (Colombia) en el período comprendido entre enero de 2013 y junio de 2014. Métodos: se realizó un estudio de tipo descriptivo de corte transversal cuantitativo, en una población estimada de 350 niños y una muestra a conveniencia de 89, en edades entre 7 y 15 años, que cumplieron con los criterios de inclusión establecidos aplicando Índice de Thylstrup y Fejerskov (TFI). Resultados: el grado de severidad que más predominó en la arcada superior fue TF2, con un porcentaje de 53.93%, correspondiente al primer molar (16); seguido de TF3, con 33.0% en el incisivo lateral (12). A su vez, en la arcada inferior, el grado de severidad de mayor predominio fue TF2, con 48.31% en los primeros molares derecho e izquierdo (46 y 36); seguido de TF1, con 47.19% en el incisivo central (31). Conclusión: la severidad TF2 fue la más predominante en ambas arcadas en incisivos y primeros molares, lo que corresponde a un nivel leve.
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van Dooremalen, Wies T. M., Stephan P. Verweij, Janneke E. den Hartog, Carole Kebbi-Beghdadi, Sander Ouburg, Gilbert Greub, Servaas A. Morré, and Anne Ammerdorffer. "Screening of Chlamydia trachomatis and Waddlia chondrophila Antibodies in Women with Tubal Factor Infertility." Microorganisms 8, no. 6 (June 17, 2020): 918. http://dx.doi.org/10.3390/microorganisms8060918.
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Waddlia chondrophila is an emerging intracellular pathogen belonging to the order of Chlamydiales, and was previously associated with adverse pregnancy outcomes, as well as tubal factor infertility (TFI). In this study, we investigate the link between both W. chondrophila and Chlamydia trachomatis IgG seropositivity and TFI. Antibodies against both bacteria were measured in 890 serum samples of women visiting a fertility clinic. After a hysterosalpingography and/or laparoscopy, they were classified as either TFI-negative (TFI−) or TFI-positive (TFI+). The total seroprevalence was 13.4% for C. trachomatis and 38.8% for W. chondrophila. C. trachomatis antibodies were present significantly more often in the TFI+ group than in the TFI− group, while for W. chondrophila no difference could be observed. In conclusion, our study confirms the association between C. trachomatis seropositivity and TFI, but no association was found between W. chondrophila seropositivity and TFI. The high percentage of W. chondrophila seropositivity in all women attending a fertility clinic does, however, demonstrate the need for further research on this Chlamydia-like bacterium and its possible role in infertility.
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Saldarriaga, Alexandra, Diego Rojas-Gualdrón, Manuel Restrepo, Lourdes Santos-Pinto, and Fabiano Jeremias. "Dental fluorosis severity in children 8-12 years old and associated factors." Acta Odontológica Latinoamericana 34, no. 2 (September 2021): 156–65. http://dx.doi.org/10.54589/aol.34/2/156.
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The aim of this study was to determine the frequency and severity of dental fluorosis (DF) and the association between severity and risk factors. In a cross-sectional study, 8- to 12-year-old children, born in a Colombian district, were evaluated according to the Thylstrup and Fejerskov Index (TFI) by two calibrated examiners. Molar Incisor Hypomineralization (MIH) and dental caries (DC) were also evaluated. Ordinal logistic regression was applied p<0.05). Risk factors and lifestyle factors were collected using a questionnaire answered by parents. DF was detected in 76 (98.7%) of the children (average of 18.4 ±1.81 permanent teeth affected). Grade TF2 was the most frequently observed (34.8%); TF5 was observed in all age groups; TF6- TF7 were observed in 12-year-olds. No association was found between DF severity and DC (Odds Ratio (OR)=1.35; 95%CI: 0.56-3.26) or MIH (OR=1.39; 95%CI: 0.43-4.46). DF severity was significantly associated with use of an indoor wood stove for food preparation (OR = 9.34; 95%CI: 1.11-78.57) and use of a pea-sized volume of toothpaste (OR = 27.42; 95%CI: 1.57-477.36). Prevalence of DC was 38.1% and prevalence of MIH was 14.4%. In this population, the frequency of DF was high and severity was associated with use of an indoor wood stove for food preparation and toothpaste amount used during childhood.
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Kobayashi, S., H. Shibata, I. Kurihara, K. Yokota, N. Suda, I. Saito, and T. Saruta. "Ubc9 interacts with chicken ovalbumin upstream promoter-transcription factor I and represses receptor-dependent transcription." Journal of Molecular Endocrinology 32, no. 1 (February 1, 2004): 69–86. http://dx.doi.org/10.1677/jme.0.0320069.
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Chicken ovalbumin upstream promoter-transcription factors (COUP-TFs) are orphan receptors involved in regulation of neurogenesis and organogenesis. COUP-TF family members are generally considered to be transcriptional repressors and several mechanisms have been proposed to underlie this activity. To explore novel transcriptional coregulators for COUP-TFs, we used the COUP-TFI as bait in a yeast two-hybrid screen of an adrenocortical adenoma cDNA library. We have identified Ubc9, a class E2 conjugating enzyme of small ubiquitin-related modifier (SUMO)-1 as a COUP-TFI corepressor. Ubc9 interacts with COUP-TFI in yeast and in glutathione S-transferase pulldown and coimmunoprecipitation assays. Fluorescence imaging studies show that both Ubc9 and COUP-TFI are colocalized in the nuclei of transfected COS-1 cells. The C-terminal region of Ubc9 encoding amino acids 59-158 interacts with the C-terminus of COUP-TFI encoding amino acids 383-403, in which transcriptional repression domains are located. Mammalian one-hybrid assays utilizing a variety of Ubc9 fragments fused to Gal4 DNA-binding domain show that a Ubc9 fragment encoding amino acids 1-89 contains autonomous transferrable repression domain. Transfection of Ubc9 into COS-1 cells markedly enhances transcriptional repression by Gal4 DNA-binding domain-fused to COUP-TFI(155-423), but not by Gal4-COUP-TFI(155-388) which lacks a repressor domain. Coexpression of a C-terminal deletion mutant of Ubc9(1-58), which fails to interact with COUP-TFI, but retains a transcriptional repression domain, has no effect on Gal4-COUP-TFI-mediated repression activity. These findings indicate that interaction of Ubc9 with COUP-TFI is crucial for the corepressor function of Ubc9. Overexpression of Ubc9 similarly enhances COUP-TFI-dependent repression of the promoter activity of the bovine CYP17 gene encoding steroid 17alpha-hydroxylase. In addition, the C93S mutant of Ubc9, which abrogates SUMO-1 conjugation activity, continues to function as a COUP-TFI corepressor. Our studies indicate that Ubc9 functions as a novel COUP-TFI corepressor, the function of which is distinct from its SUMO-1 conjugating enzyme activity.
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Um, Jung Hwan, Soon Heum Kim, and Dong In Jo. "A Case of Tumor of Follicular Infundibulum in Parietal Scalp." Korean Society for Head and Neck Oncology 37, no. 2 (November 30, 2021): 57–60. http://dx.doi.org/10.21593/kjhno/2021.37.2.57.
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Tumor of follicular infundibulum (TFI) is a rare benign cutaneous appendage tumor that does not have characteristic clinical features. It is mainly present in the head, neck, and trunk as a solitary lesion. In particular, TFI typically manifests as a plate-like proliferation with multiple thin epidermal connections comprise of monomorphic cells. TFI do not represent cutaneous characteristics, but have clinical significance because TFI is associated with basal cell carcinoma and Cowden's syndrome. We report a case of TFI in parietal scalp with a review of literatures.
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Faheem, Ahmed F., Hussain U. Bahia, and Hossein Ajideh. "Estimating Results of a Proposed Simple Performance Test for Hot-Mix Asphalt from Superpave Gyratory Compactor Results." Transportation Research Record: Journal of the Transportation Research Board 1929, no. 1 (January 2005): 104–13. http://dx.doi.org/10.1177/0361198105192900113.
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This study intended to use the Superpave® gyratory compactor (SGC) as a basis for estimating the stability of asphalt mixtures as a surrogate for proposed method for the simple performance test. Several asphalt mixtures were produced with varying aggregate sources, asphalt contents, and gradations. Every mixture was compacted with the SGC and evaluated with the repeated compression test procedure for rutting measurements recommended by NCHRP Project 9–19 and the AASHTO 2002 pavement design manual to evaluate whether the results from the SGC can be related to the rutting of mixtures. Densification curves produced by the SGC were used to determine the volumetric properties besides the calculation of the traffic densification index (TDI), which represents the densification experienced by traffic loading during pavement service life. The traffic force index (TFI) was also calculated with a special accessory added to the SGC during compaction (the pressure distributor analyzer). The TFI represents the work done by the traffic to densify the mixture. Results from the mixture rutting tests were used to estimate the flow number (FN). The FN, an important mixture property, is shown to have a strong correlation to the TFI. The TFI was also found to be strongly correlated with the TDI and gives an opportunity to estimate the mixture resistance to compaction forces with the use of its volumetric behavior. The main finding of the study is that the SGC appears to give information that can be used to characterize the stability of the mixtures. Such information could be used as an initial screening criterion to select mixtures for various traffic levels.
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Lin, Chia-Hui, Chieh-Yu Liu, and Jiin-Ru Rong. "Psychometric Properties of the Taiwanese Version of the Tilburg Frailty Indicator for Community-Dwelling Older Adults." Healthcare 9, no. 9 (September 10, 2021): 1193. http://dx.doi.org/10.3390/healthcare9091193.
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Screening the frailty level of older adults is essential to avoid morbidity, prevent falls and disability, and maintain quality of life. The Tilburg Frailty Indicator (TFI) is a self-report instrument developed to assess frailty for community-dwelling older adults. The aim of this study was to explore the psychometric properties of the Taiwanese version of TFI (TFI-T). The sample consisted of 210 elderly participants living in the community. The scale was implemented to conduct a confirmatory factor analysis (CFA) test for validity. The models were evaluated through sensitivity, specificity, area under the curve, and receiving operating characteristic (ROC) curve. CFA was performed to evaluate construct validity, and the TFI-T has a goodness of fit with the three-factor structure of the TFI. Totally, the 15 items of TFI-T have acceptable internal consistency (Cronbach’s alpha = 0.78), and test–retest reliability (r = 0.88, p < 0.001). The criterion-related validity was examined, the TFI-T correlation with the Kihon Checklist (KCL) score (r = 0.74; p < 0.001). The cutoff of 5.5 based on the Youden index was considered optimal. The area under the ROC curve analysis indicated that the TFI-T has good accuracy in frailty screening. The TFI-T exhibits good reliability and validity and can be used as a sensitive and accurate instrument, which is highly applicable to screen frailty in Taiwan among older adults.
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HARADA, Ken. "Twin-Foucault Imaging (TFI)." Journal of the Vacuum Society of Japan 57, no. 9 (2014): 348–54. http://dx.doi.org/10.3131/jvsj2.57.348.
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Yoon, Kyungsil, Chien-Cheng Chen, Asuka Orr, Patricia Barreto, Phanourios Tamamis, and Stephen Safe. "Activation of COUP-TFI by a Novel Diindolylmethane Derivative." Cells 8, no. 3 (March 7, 2019): 220. http://dx.doi.org/10.3390/cells8030220.
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Chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI) is an orphan receptor and member of the nuclear receptor superfamily. Among a series of methylene substituted diindolylmethanes (C-DIMs) containing substituted phenyl and heteroaromatic groups, we identified 1,1-bis(3′-indolyl)-1-(4-pyridyl)-methane (DIM-C-Pyr-4) as an activator of COUP-TFI. Structure activity studies with structurally diverse heteroaromatic C-DIMs showed that the pyridyl substituted compound was active and the 4-pyridyl substituent was more potent than the 2- or 3-pyridyl analogs in transactivation assays in breast cancer cells. The DIM-C-Pyr-4 activated chimeric GAL4-COUP-TFI constructs containing full length, C- or N-terminal deletions, and transactivation was inhibited by phosphatidylinositol-3-kinase and protein kinase A inhibitors. However, DIM-C-Pyr-4 also induced transactivation and interactions of COUP-TFI and steroid receptor coactivators-1 and -2 in mammalian two-hybrid assays, and ligand-induced interactions of the C-terminal region of COUP-TFI were not affected by kinase inhibitors. We also showed that DIM-C-Pyr-4 activated COUP-TFI-dependent early growth response 1 (Egr-1) expression and this response primarily involved COUP-TFI interactions with Sp3 and to a lesser extent Sp1 bound to the proximal region of the Egr-1 promoter. Modeling studies showed interactions of DIM-C-Pyr-4 within the ligand binding domain of COUP-TFI. This report is the first to identify a COUP-TFI agonist and demonstrate activation of COUP-TFI-dependent Egr-1 expression.
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Cuevas-Espinosa, D. M., E. A. Martinez-Mier, M. Ando, G. A. Castiblanco, F. Cortes, C. M. Rincon-Bermudez, and S. Martignon. "In vitro Validation of Quantitative Light-Induced Fluorescence for the Diagnosis of Enamel Fluorosis in Permanent Teeth." Caries Research 51, no. 5 (2017): 515–26. http://dx.doi.org/10.1159/000479905.
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This study aimed to validate quantitative light-induced fluorescence (QLF) as a diagnostic tool for mild and moderate enamel fluorosis in permanent teeth, comparing it to visual diagnosis and histological assessment completed using polarized light microscopy (PLM). The buccal surfaces of 139 teeth were visually classified using the Thylstrup and Fejerskov Index (TFI) into sound (TFI 0; n = 17), mild (TFI 1-2; n = 69), and moderate (TFI 3-4; n = 43) fluorosis. Fluorosis was then assessed with QLF (variables ΔF, A, and ΔQ at 5-, 15-, and 30-radiance thresholds) using as reference areas the entire surface and a region of interest (ROI), identified as the most representative region of a fluorosis lesion. PLM images of longitudinal thin sections including the ROI were assessed for histological changes. Correlations among TFI, PLM, and QLF were determined. A receiver-operating characteristic curve was conducted to determine QLF's diagnostic accuracy when compared to the TFI and PLM assessments. This was used to assess the probability that the images were correctly ranked according to severity as determined by PLM and TFI. A positive correlation was found between QLF and PLM, and between QLF and TFI. QLF showed the highest sensitivity and specificity for the diagnosis of mild fluorosis. There was also a strong agreement between TFI and PLM. The selection of a ROI resulted in a stronger correlation with TFI and PLM than when the entire surface was used. The study results indicate that defining an ROI for QLF assessments is a valid method for the diagnosis of mild and moderate enamel fluorosis.
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Hayajneh, Audai A. "The Psychometric Properties of the Arabic Version of the Tilburg Frailty Indicator." Global Journal of Health Science 11, no. 9 (July 27, 2019): 123. http://dx.doi.org/10.5539/gjhs.v11n9p123.
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Frailty is a loss of human function in one or more physical, psychological, or social aspects. The purpose of this study was to establish the reliability and validity of the Arabic (Jordan) version of the Tilburg Frailty Indicator (TFI) in older Jordanian adults. A total of 109 participants from Irbid, Jordan were recruited. Reliability tests were conducted by determining the KR-20 values. The total score of the Arabic (Jordan) version of the TFI had good reliability (KR 20 = 0.77) and good convergent and divergent validity with the corresponding scales: physical-TFI and the SF36-physical function (r = -0.317), psychological-TFI and GDS (r = 0.458), and social-TFI and the SF 36-social function (r = -0.304). The Arabic (Jordan) version of the TFI is reliable and valid for use in Jordanian population.
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Rademaker, Maaike M., Inge Stegeman, Anne E. M. Brabers, Judith D. de Jong, Robert J. Stokroos, and Adriana L. Smit. "Associations between Demographics, Tinnitus Specific-, Audiological-, General- and Mental Health Factors, and the Impact of Tinnitus on Daily Life." Journal of Clinical Medicine 11, no. 15 (August 5, 2022): 4590. http://dx.doi.org/10.3390/jcm11154590.
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Our objective was to study associations between demographics, tinnitus specific-, audiological-, general- and mental health characteristics, and impact of tinnitus in the general population. In this cross-sectional survey study in the Dutch population, data were prospectively gathered. Tinnitus impact was assessed with the Tinnitus Functional Index (TFI). We included participants who experienced tinnitus and for whom a total TFI score could be calculated (n = 212). We performed univariable and multivariable regression analyses. Due to logarithmical transformation, the B-scores were back-transformed to show the actual difference in points on the TFI. People who considered hyperacusis a small problem had a 12.5-point higher TFI score, those who considered it a mediocre problem had a 17.6-point higher TFI score and those who considered it a large problem had a 24.1-point higher TFI score compared to people who did not consider hyperacusis a problem. People who indicated having minor hearing problems had a 10.5-point higher TFI score, those with mediocre hearing problems had a 20.4-point higher TFI score and those with severe hearing problems had a 41.6-point higher TFI score compared to people who did not have subjective hearing problems. In conclusion, audiological risk factors, such as hearing problems and hyperacusis, have the largest association with the impact of tinnitus on daily life, compared to other assessed variables. The results of this study can be used in future research to find targeted interventions to diminish the impact of tinnitus.
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Zieger, Nora, Maryam Kazerani Pasikhani, Tobias Straub, Alyssa Nicholls, Gerulf Hänel, Jan Wulf, Michaela Scheurer, et al. "Treatment-Free Intervals during CD19xCD3 BiTE ® Construct-Mediated T-Cell Stimulation Induce Functional Reinvigoration and Transcriptional Reprogramming of Exhausted T Cells." Blood 138, Supplement 1 (November 5, 2021): 513. http://dx.doi.org/10.1182/blood-2021-150178.
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Abstract Blinatumomab is a bispecific T-cell engager (BiTE ®) construct approved for treatment of relapsed/refractory (r/r) B-cell precursor acute lymphoblastic leukemia (BCP-ALL). It is applied as continuous infusion over 28 days and induces remissions in 43 % of r/r patients. Responses correlated to T-cell expansion (Topp et al. 2011, Zugmaier et al. 2015). Mimicking the clinical application in an in vitro model system, we showed previously that continuous stimulation (CONT) with AMG 562, a half-life extended CD19xCD3 BiTE ® construct, induces T-cell exhaustion, as seen in chronic infections. Also, we could enhance T-cell function in vitro by treatment-free intervals (TFI) (Zieger et al. ASH 2020). To identify genetic drivers of enhanced T-cell function that could provide anti-exhaustion targets for clinical use, we aimed to characterize the transcriptome of exhausted vs rested T cells by bulk RNA sequencing of CONT and TFI T cells. To simulate CONT vs TFI AMG 562 stimulation, cocultures of healthy donor T cells and CD19 + OCI-Ly1 cells were set up for 28 days under CONT or TFI (7 days on/7 days off) AMG 562 exposure. On day 0, 7, 14 and 21, we sorted 5x10 5 CD3 + T cells for transcriptome assessment (n=3). In parallel, function of TFI vs CONT T cells was analyzed in vitro: (1) AMG 562-mediated killing was evaluated as specific lysis of CD19 + Ba/F3 cells after 72h, (2) T-cell expansion during the killing assay was calculated as fold change (FC) of CD2 + counts, (3) AMG 562-mediated cytokine secretion was evaluated via intracellular staining. We could confirm that function of Day 14 TFI vs CONT T cells was significantly enhanced (% specific lysis: TFI=99±2.2, CONT=34±4.2, p<0.0001; T-cell expansion as FC: TFI=4±0.8, CONT=1±0.6, p<0.01; Granzyme B MFI ratio of CD8 +: TFI=451±168, CONT=144±33, p<0.0001). RNA sequencing and differentially expressed gene (DEG) analysis of Day 14 TFI vs CONT T cells identified 1902 significantly up- and 2603 downregulated genes (p adj<0.05). Unsupervised clustering of the top 100 DEG showed striking similarity in gene expression patterns in unstimulated (Day 0) and Day 14 TFI vs CONT T cells. Intriguingly, genes related to memory and stemness were highly enriched on Day 0 and Day 14 TFI (TCF7, IL7R, SELL). Among the top downregulated genes in Day 14 TFI vs CONT T cells, we identified genes related to cell cycle (CCNB1, CDK1) and activation (IL2RA). Exhaustion-associated genes were significantly downregulated in Day 14 TFI vs CONT T cells (LAG-3, PDCD1, NR4A3, IRF4). Pathway analysis of Day 14 TFI vs CONT T cells confirmed downregulation of cell cycle (G2M checkpoint, normalized enrichment score (NES)=-2.47, E2F Targets, NES=-2.64; p adj=6.3E -10) and metabolism (MTORC1 signaling, NES=-2.27, OXPHOS, NES=-2.03; p adj=6.3E -10). Gene set enrichment analysis (GSEA) also showed reduction of effector compared to memory-related genes in Day 14 TFI vs CONT (GSE9650, NES=-1.95, FDR q=0.0). After restimulation of TFI T cells with AMG 562 (Day 21 TFI) we observed higher effector function in TFI vs CONT T cells (% specific lysis, TFI=51±8, CONT=23±7, p<0.0001). DEG analysis of Day 21 TFI vs CONT identified 1417 significantly up- and 1821 downregulated genes (p adj<0.05). Unsupervised clustering of the top 100 DEG revealed a unique gene set in Day 21 CONT T cells enriched in apoptosis-related genes (TRAF1, ELAPOR1, BMF). Among the top upregulated genes in Day 21 TFI T cells were genes involved in activation and growth (DPP4, SLC3A2) and cell cycle (CDK1, PLK1), induced by AMG 562 restimulation after TFI. Exhaustion-related genes were downregulated in Day 21 TFI vs CONT T cells (LAG-3, BTLA, NFATC1). Remarkably, identical pathways downregulated on Day 14 TFI were enriched in Day 21 TFI T cells (G2M checkpoint, NES=2.63, MTORC1 signaling, NES=2.36, OXPHOS, NES=2.42; p adj=7.1E -10). Accordingly, GSEA showed enrichment of effector- rather than memory-related genes on Day 21 TFI vs CONT (GSE9650, NES=1.75, FDR q=0.0). Together, our data suggest that TFI functionally and transcriptionally rejuvenates T cells. Upon restimulation (Day 21 TFI), T cells reengage an effector program and are less exhausted compared to CONT T cells. In future analyses we will correlate RNA expression levels to functional traits using whole genome co-expression network analysis (WGCNA). Thereby we aim to identify gene clusters critical for persistent T-cell function that might serve as targets to improve efficacy of T-cell based immunotherapies. Figure 1 Figure 1. Disclosures Lacher: Roche: Research Funding. Brauchle: Adivo: Current Employment. von Bergwelt: Kite/Gilead: Honoraria, Research Funding, Speakers Bureau; Miltenyi: Honoraria, Research Funding, Speakers Bureau; MSD Sharpe & Dohme: Honoraria, Research Funding, Speakers Bureau; Roche: Honoraria, Research Funding, Speakers Bureau; Mologen: Honoraria, Research Funding, Speakers Bureau; Novartis: Honoraria, Research Funding, Speakers Bureau; Astellas: Honoraria, Research Funding, Speakers Bureau; BMS: Honoraria, Research Funding, Speakers Bureau. Weigert: Janssen: Speakers Bureau; Epizyme: Membership on an entity's Board of Directors or advisory committees; Roche: Research Funding. Theurich: Amgen: Consultancy, Honoraria; BMS/Celgene: Consultancy, Honoraria; GSK: Consultancy, Honoraria; Janssen: Consultancy, Honoraria; Pfizer: Consultancy, Honoraria; Sanofi: Consultancy, Honoraria; Takeda: Consultancy, Honoraria. Buecklein: Miltenyi: Research Funding; Novartis: Consultancy, Other: congress and travel support, Research Funding, Speakers Bureau; BMS/Celgene: Consultancy, Research Funding; Pfizer: Consultancy, Honoraria, Speakers Bureau; Amgen: Consultancy, Honoraria; Kite/Gilead: Consultancy, Honoraria, Other: Congress and travel support, Research Funding. Kischel: Amgen GmbH Munich: Current Employment. Subklewe: Klinikum der Universität München: Current Employment; Takeda: Speakers Bureau; Pfizer: Consultancy, Speakers Bureau; Janssen: Consultancy; Seattle Genetics: Consultancy, Research Funding; Roche: Research Funding; Novartis: Consultancy, Research Funding, Speakers Bureau; MorphoSys: Research Funding; Miltenyi: Research Funding; Gilead: Consultancy, Research Funding, Speakers Bureau; Amgen: Consultancy, Research Funding, Speakers Bureau; BMS/Celgene: Consultancy, Research Funding, Speakers Bureau.
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Ozsoy, Gulsah, Esra Ates Bulut, Baris Gurpinar, Nursen Ilcin, and Ahmet Turan Isik. "Determination of an Optimal Frailty Cutoff Score of Tilburg Frailty Indicator and Frailty Associated Factors in Community-Dwelling Turkish Older Adults." Annals of Geriatric Medicine and Research 25, no. 4 (December 31, 2021): 294–300. http://dx.doi.org/10.4235/agmr.21.0086.
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Background: Frailty is a multidimensional and dynamic state that has adverse physical, psychological, and social outcomes. The Tilburg Frailty Indicator (TFI) has the most robust evidence of reliability and validity for assessing frailty. However, the characteristics of TFI have not been investigated in detail. This study aimed to set a cutoff score for frailty and evaluate frailty-associated factors in community-dwelling older adults.Methods: This cross-sectional study assessed frailty according to both the TFI and Fried criteria. The Geriatric Depression Scale, basic and instrumental activities of daily living, and Hospital Anxiety and Depression Scale-Anxiety subscale were also implemented.Results: This study included 166 older adults. The area under the receiver operating characteristic curve was 0.735 (95% confidence interval, 0.648–0.823). A TFI cutoff point of 8, showed a sensitivity of 60% and specificity of 72.5% for the prediction of frailty (p<0.05). Frailty according to the TFI was more associated with the physical and psychological parameters, while frailty according to the Fried score was more closely related to the physical parameters (p<0.05).Conclusion: The results of this study suggested an optimal TFI cutoff score of 8 as a frailty instrument in community-dwelling older adults. Additionally, the TFI included physical, psychological, and social aspects, thereby providing a multidimensional evaluation of frailty.
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Küçükeşmen, Çiḡdem, and Hayriye Sönmez. "Microleakage of Class-V Composite Restorations with Different Bonding Systems on Fluorosed Teeth." European Journal of Dentistry 02, no. 01 (January 2008): 48–58. http://dx.doi.org/10.1055/s-0039-1697354.
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ABSTRACTObjectives: To examine the effects of dental fluorosis and total and self-etch bonding systems on microleakage of Class-V composite restorations in permanent molar teeth.Methods: Teeth were classified as three main groups according to Thylstrup-Fejerskov Index (TFI) as TFI=0, TFI=1-3 and TFI=4. Total and self-etching/bonding procedures were determined for each main group. Total-etching procedures were acid-etching for 30s and acid-etching for 60s with Single Bond/total-etch bonding system. Self-etching procedure was applied with Prompt-L-Pop/self-etch bonding system. 63 box-shaped Class-V cavities (4×2×2 mm) were prepared on mid-buccal/palatinal/lingual surfaces of teeth for totalling nine test groups (n=7). Restorations with composite material (Charisma) polymerized with halogen unit for 40s. Teeth were thermocycled between +5°C - +55°C (×500), immersed in 0.5% basic-fuchsin solution (37°C, 24h) and separated longitudinally in bucco-lingual direction. Dye penetration was examined under stereomicroscope (3.2×10).Results: Microleakage levels were higher in teeth of TFI=4 than TFI=0 occlusally or cervically (P<.05). In TFI=0; total-etched teeth for 30s have statistically shown more leakage than total-etched teeth for 60s occlusally or cervically (P<.05). In TFI=4; microleakage levels were significantly higher for 30s than 60s cervically (P<.05). For all TFI levels, microleakage was commonly increased with self-etch system than total-etch system (P<.05). Generally, higher leakage was present at cervical margins than occlusal margins (P<.05).Conclusions: Microleakage has increased by severity of dental fluorosis. Generally, more leakage was observed in total-etched teeth for 30s than 60s. Microleakage was commonly higher in self-etched teeth than total-etched teeth. More leakage was present at cervical margins than occlusal margins. (Eur J Dent 2008;2:48-58)
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Brüggemann, Petra, Agnieszka Szczepek, Tobias Kleinjung, Michael Ojo, and Birgit Mazurek. "Validierung der deutschen Version des Tinnitus Functional Index (TFI)." Laryngo-Rhino-Otologie 96, no. 09 (May 12, 2017): 615–19. http://dx.doi.org/10.1055/s-0042-122342.
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Zusammenfassung Tinnitus ist eine Dysfunktion im Hörsystem mit deutlicher Beeinträchtigung der Patienten durch assoziierte Komorbidität wie Hörstörungen, Schlaf- und Konzentrationsprobleme oder affektive Verstimmungen. Mind. 5% der Bevölkerung sind von Tinnitus betroffen, mind. 2% Prozent leiden unter einem behandlungsbedürftigen Ohrgeräusch. Im englischsprachigen Raum wurde ein neuer Fragebogen zur Diagnostik und zur Messung von Therapieeffekten entwickelt, der Tinnitus-Functional Index (TFI). Die vorliegende Validierung einer deutschsprachigen Version des Tinnitus-Functional Index (TFI) wurde an 229 Patienten mit chronischem Tinnitus durchgeführt. Als Referenzskala diente der Tinnitusfragebogen von Goebel u. Hiller und die „Hamburger Allgemeine Depressionsskala“ (HADS). Eine Messwiederholung nach 7 Tagen Therapie diente zur Messung der Veränderungssensitivität. Die faktorenanalytische Überprüfung resultiert in 8 Subskalen wie von Meikle et al. [2012] für das Original beschrieben. Die deutsche Fassung des TFI erreicht eine exzellente Reliabilität (Cronbach’s α=0,93) und die interne Skalenkonsistenz entsprach der TFI-Originalversion. Die Korrelation des TFI mit dem Tinnitusfragebogen betrug r=0,83, und mit dem HADS r=0,49 für die Depressionsitems und r=0,51 für die Angstitems. Die Ergebnisse sprechen für die Validität des deutschsprachigen TFI. Er erweist sich als ein schnelles und statistisch belastbares Instrument zur Bestimmung der Tinnitusbeeinträchtigung und zur Messung von Veränderungseffekten durch Therapie.
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Kok, Robert M., Steven Smeele, Elsbeth-Nynke Bos, Jamila Douairi, and Richard Christiaan Oude Voshaar. "443 - Measuring frailty in older psychiatric patients." International Psychogeriatrics 32, S1 (October 2020): 161. http://dx.doi.org/10.1017/s1041610220002951.
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IntroductionFrailty is a common clinical syndrome in older adults that carries an increased risk for poor health outcomes. Early identification of frailty may help optimizing quality of care. Fried's frailty criteria are often used as the gold standard of frailty. However, it takes too much time and the availability of a hand grip strength meter to measure these criteria in daily practice. Screening instruments for frailty such as the Groningen Frailty Indicator (GFI) and the Tilburg Frailty Indicator (TFI), are available. However, it is not yet certain whether the usual cut-off values are applicable to older psychiatric patients.AimTo determine internal consistency, sensitivity, specificity and area under the curve (AUC) of the receiver operating characteristic-curve (ROC- curve) of the GFI and TFI using validated cut-off values, and to determine the optimal cut-off value in older psychiatric patients.MethodsBaseline data of an ongoing prospective cohort study were used. In this study GFI, TFI and Fried-criteria were determined in hospitalized and non-hospitalized psychiatric patients over 65 years old.ResultsA total of 145 participants were enrolled, 90 of which were hospitalized and 55 were non-hospitalized. Median age of participants was 75.2 (SD =7) years, 108 were female. Prevalence of frailty according to Fried-criteria was 29.7%. Internal consistency (Cronbach's alpha) of the GFI was 0.76 and TFI = 0.75. Using the validated cut-off value and the Fried- criteria as reference, sensitivity of the GFI (≥4) was 0.95 (95% CI 0.83 - 0.99) and specificity 0.27 (95%CI 0.19 - 0.37). Sensitivity of the TFI (≥5) was 0.98 (95% CI 0.86 - 1.00) and specificity 0.31 (95% CI 0.23 - 0.41). The optimum cut-off value for both the GFI and TFI was ≥8. The AUC of the ROC-curve of GFI and TFI were 0.82 (95% CI 0.75 - 0.90) and 0.79 (95% CI 0.72 - 0.87), respectively.ConclusionWe found an acceptable internal consistency and AUC of both the GFI and the TFI in older psychiatric patients. Increasing the cut-off values of both GFI and TFI seems necessary to lower the amount of false positives in this population.
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Boisen, Michelle M., Jamie L. Lesnock, Scott D. Richard, Sushil Beriwal, Joseph L. Kelley, Kristin K. Zorn, and Robert P. Edwards. "Second-line Intraperitoneal Platinum-based Therapy Leads to an Increase in Second-line Progression-free Survival for Epithelial Ovarian Cancer." International Journal of Gynecologic Cancer 26, no. 4 (May 2016): 626–31. http://dx.doi.org/10.1097/igc.0000000000000667.
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ObjectiveOnly 3% of patients with epithelial ovarian cancer (EOC) have a longer treatment-free interval (TFI) after second-line intravenous (IV) platinum chemotherapy than with frontline IV therapy. We sought to examine what impact second-line combination IV/intraperitoneal (IV/IP) platinum therapy might have on the ratio of second-line to first-line TFI in patients treated with second-line IP platinum chemotherapy for first recurrence after front-line IV therapy.MethodsA retrospective analysis of women who received combination platinum-based IV/IP chemotherapy for recurrent EOC between January 2005 and March 2011 was conducted. Patients were identified from the tumor registry, and office records from a large gynecologic oncology practice and patient records were reviewed. The first and second TFIs were defined as the time from the end of previous platinum-based therapy to the start of next therapy.ResultsTwenty-five women received IV/IP chemotherapy for their first EOC recurrence after IV chemotherapy. In 10 patients (40%), we observed a longer TFI after IV/IP chemotherapy than after primary IV chemotherapy. For these 10 patients, the median TFI for primary response was 22 months (range, 15–28), whereas median TFI after IV/IP chemotherapy for recurrent disease was 37 months (range, 12–61).ConclusionsFor EOC patients with limited peritoneal recurrence, 40% of patients had a second-line IP-platinum TFI that exceeded their frontline IV-platinum TFI compared to published data. These data support the use of IV/IP chemotherapy as a treatment for recurrence.
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Fernández, Marta, María Cuesta, Ricardo Sanz, and Pedro Cobo. "Comparison of Tinnitus Handicap Inventory and Tinnitus Functional Index as Treatment Outcomes." Audiology Research 13, no. 1 (December 26, 2022): 23–31. http://dx.doi.org/10.3390/audiolres13010003.
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Background: Tinnitus is an audiological disorder for which there are no objective measuring tools. Thus, many self-report questionnaires have been proposed to assess its severity. These questionnaires have been judged for their capacity to assess the tinnitus severity at baseline, their sensitivity to treatment-related changes (responsiveness), and their resolution. Methods: The most widely used questionnaires for clinical and research studies are the Tinnitus Handicap Inventory (THI) and the Tinnitus Functional Index (TFI). While both questionnaires have been recognized as good evaluators of the baseline tinnitus severity, the latter is considered to be more responsive to changes following treatments. Objectives: The aim of this work is to provide a preliminary comparison of the performance of both questionnaires in the initial and final tinnitus severity assessment of a cohort of patients undergoing a four-month Enriched Acoustic Environment (EAE) therapy. Results: The EAE therapy provided a 30 and 26 point reduction in THI and TFI, respectively. A good correlation is obtained between the THI and TFI questionnaires at baseline and after the treatment. Conclusion: At baseline, the THI provided a higher score than the TFI for a higher degree of tinnitus but a lower score for lower tinnitus severity. Both THI and TFI were good questionnaires for baseline assessment and for treatment-related changes. The THI provided a slightly higher score drop than the TFI following the treatment, although the TFI had better resolution.
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LaVerda, David, Lisa N. Albanese, Paul E. Ruther, Sandra G. Morrison, Richard P. Morrison, Kevin A. Ault, and Gerald I. Byrne. "Seroreactivity to Chlamydia trachomatis Hsp10 Correlates with Severity of Human Genital Tract Disease." Infection and Immunity 68, no. 1 (January 1, 2000): 303–9. http://dx.doi.org/10.1128/iai.68.1.303-309.2000.
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ABSTRACT We have identified the chlamydial heat shock protein Hsp10 as a potential correlate to the immunopathogenic process in women with tubal factor infertility (TFI). The human serologic response to chlamydial Hsp10, Hsp60, and major outer membrane protein (MOMP) was measured by enzyme-linked immunosorbent assay. Three populations of women were studied: uninfected controls (CU), acutely infected (AI) women, and women with TFI. Sera from women in the AI and TFI groups both recognized Hsp10 more frequently and at a higher overall level than sera from healthy uninfected controls. Moreover, the infertile women had significantly greater Hsp10 seroreactivity than acutely infected women, indicating a concomitant increase of Hsp10 recognition in populations with increasing levels of disease severity. Hsp60 reactivity showed a similar correlation in these populations, while MOMP reactivity peaked at the same level in both AI and TFI populations but did not increase with disease severity. Test populations were standardized by level of reactivity to formalin-fixed Chlamydia trachomatis elementary bodies (EBs) to address whether these associations were reflections of increased overall chlamydial exposure rather than a property specific to Hsp10. Associations between Hsp10 seropositivity and TFI were greater in the EB+ subgroup while associations among the EB− subgroup were diminished. When restricted to the EB+ subgroups, Hsp60 and MOMP responses in the TFI population did not increase significantly over the level of AI group responses. Thus, among women with similar exposure to chlamydiae, the serologic response to Hsp10 exhibited a stronger correlation with TFI than did the response to Hsp60 or MOMP. These findings support the hypothesis that the serological response toC. trachomatis heat shock proteins is associated with the severity of disease and identifies Hsp10 as an antigen recognized by a significant proportion of women with TFI.
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Valzon, May, and Ayu Permata. "PENGGUNAAN SCIATIC FUNCTIONAL INDEX (SFI) DAN TIBIAL FUNCTIONAL INDEX (TFI) DALAM PENILAIAN REGENERASI MOTORIS SARAF TEPI." Collaborative Medical Journal (CMJ) 3, no. 1 (January 21, 2020): 1–7. http://dx.doi.org/10.36341/cmj.v3i1.1094.
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Regenerasi motorik saraf tepi dapat dinilai dengan menggunakan Sciatic Function Index (SFI) dan Tibial Function Index (TFI). Namun, studi komprehensif mengenai aspek anatomi dan metodologis pengukuran belum memadai. Penelitian ini bertujuan membandingkan penggunaan TFI dan SFI dalam menilai pemulihan fungsi motorik saraf tepi. Penelitian ini menggunakan desain posttest only with control group. Delapan belas tikus Wistar jantan dibagi menjadi tiga kelompok. Kelompok I, nervus ischiadicus dicederai 5mm proksimal terhadapat bifurkasi nervus ischiadicus kaki belakang kanan. Kelompok II, nervus tibialis dicederai 5mm proksimal dari tempat bercabang nervus cutaneous surae medialis kaki belakang kanan dan kelompok III sebagai kontrol negatif. SFI dan TFI diamati pada minggu II, IV, VI, dan VIII dan dianalisis. Hasil penelitian ini menunjukkan terdapat perbedaan yang signifikan antara nilai varians SFI dan TFI pada pengamatan minggu III, IV, dan VI (p-value < 0,05). Penggunaan TFI sebagai metode penilaian regenerasi motorik saraf tepi lebih baik dari pada penggunaan SFI yang ditunjukkan oleh nilai varians yang lebih kecil.
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Martinez, Homero, Isabelle Guelinckx, Jordi Salas-Salvadó, Joan Gandy, Stavros A. Kavouras, and Luis A. Moreno. "Harmonized Cross-Sectional Surveys Focused on Fluid Intake in Children, Adolescents and Adults: The Liq.In7 Initiative." Annals of Nutrition and Metabolism 68, Suppl. 2 (2016): 12–18. http://dx.doi.org/10.1159/000446199.
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Objective: To assess the intake of water and all other beverages in children, adolescents and adults. Methods: Three thousand six hundred eleven children (8 ± 2 years), 8,109 adolescents (13 ± 2 years) and 16,276 adults (40 ± 14 years) (47% men) were recruited in 15 cross-sectional surveys (liquid intake across 7 days, Liq.In7 study) and completed a 7-day fluid-specific record to assess total fluid intake (TFI), where TFI was defined as the sum of drinking water and other type of beverages. Results: The median TFI was 1.2, 1.2 and 1.8 liters/day in children, adolescents and adults respectively, with important differences observed between countries. Only 39% of children, 25% of adolescents and 51% of adults met the European Food Safety Authority adequate intake (AI) recommendations of water from fluids. In the surveys of Spain, France, Belgium, Germany, Turkey, Iran, Indonesia and China, water was the major contributor (47-78%) to TFI. In the adult surveys of UK, Poland, Japan and Argentina, hot beverages were the highest contributor to TFI. The fluid intake of children and adolescents in Mexico, Brazil, Argentina and Uruguay was characterized by a contribution of juices and sweet beverages that was as important as the contribution of water to TFI. Conclusion: Given that a relatively high proportion of subjects, especially children and adolescents, failed to meet the recommended AI of water from fluids and that water intake was not the highest contributor to TFI in all countries, undertaking actions to increase water intake are warranted.
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Y. N., Sharath Kumar, and Dinesha P. "TFI-FTS: An efficient transient fault injection and fault-tolerant system for asynchronous circuits on FPGA platform." International Journal of Electrical and Computer Engineering (IJECE) 11, no. 3 (June 1, 2021): 2704. http://dx.doi.org/10.11591/ijece.v11i3.pp2704-2710.
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Designing VLSI digital circuits is challenging tasks because of testing the circuits concerning design time. The reliability and productivity of digital integrated circuits are primarily affected by the defects in the manufacturing process or systems. If the defects are more in the systems, which leads the fault in the systems. The fault tolerant systems are necessary to overcome the faults in the VLSI digital circuits. In this research article, an asynchronous circuits based an effective transient fault injection (TFI) and fault tolerant system (FTS) are modelled. The TFI system generates the faults based on BMA based LFSR with faulty logic insertion and one hot encoded register. The BMA based LFSR reduces the hardware complexity with less power consumption on-chip than standard LFSR method. The FTS uses triple mode redundancy (TMR) based majority voter logic (MVL) to tolerant the faults for asynchronous circuits. The benchmarked 74X-series circuits are considered as an asynchronous circuit for TMR logic. The TFI-FTS module is modeled using Verilog-HDL on Xilinx-ISE and synthesized on hardware platform. The Performance parameters are tabulated for TFI-FTS based asynchronous circuits. The performance of TFI-FTS Module is analyzed with 100% fault coverage. The fault coverage is validated using functional simulation of each asynchronous circuit with fault injection in TFI-FTS Module.
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Xie, Jun, Qigui Yu, Linlin Yang, and Yuanyuan Sun. "A Preliminary Study of the Effects of the Tilburg Frailty Indicator, Frailty Phenotype, and Silver Nanoparticle-Silver Needle Therapy in Senile Inpatients with Frailty." Journal of Nanoscience and Nanotechnology 20, no. 10 (October 1, 2020): 6518–24. http://dx.doi.org/10.1166/jnn.2020.18602.
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This study aimed to determine the effects of Tilburg Frailty Indicator (TFI) and frailty phenotype (FP) in senile inpatients with frailty and provide a reference for the clinical evaluation of debilitating elderly patients. The effect of silver nanoparticle (AgNP)-silver needle acupuncture was also evaluated. Overall, 48 elderly inpatients with an average age of 69.5±6.2 years were included in the study. The results of two weakness assessment methods in screening the same elderly population were compared, and the correlation or consistency between the two methods was analyzed. A AgNPsilver needle was used for acupuncture treatment. The TFI score ranged from 0 to 12, with an average score of 4.0±0.7 (frailty [TFI>5] in 22 elderly patients [45.8%] and non-frailty in 26 patients [54.2%]). FP was presented in different stages, and the FP score ranged from 0 to 5, with an average score of 2.1±1.4, including non-frailty in 12 (25%) patients and pre-frailty in 19 (39.6%) patients. Moreover, 17 patients (35.4%) were debilitated. The two assessment methods showed that the degree of debilitation increased with advancing age in the elderly. The TFI score was positively associated with the defined stage of FP (r = 0.911, P <0.001). The consistency of TFI grading with phenotypic definition kappa value was 0.786 (P <0.001), and the area under the curve was 0.872 (95% confidence interval, 0.834–1.000; P <0.05). After acupuncture and moxibustion, the patient’s condition evidently improved. In this study, the proportion of non-debilitating elderly hospitalized patients was higher than that of debilitating elderly hospitalized patients, and the degree of debilitating increased with advancing age. The TFI score was positively associated with the stage of phenotypic definition, and TFI frailty assessment was highly sensitive. Both methods had screening value, but TFI was more effective in screening patients with pre-frailty than FP, resulting in the early intervention and treatment of debilitating elderly hospitalized patients. A silver needle acupuncture can be used for treating senile frailty, providing a new idea for the clinical treatment of frailty.
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Amadi, Lucky, Uchenna Onwudiegwu, Adebanjo B. Adeyemi, Chiemezie N. D. Nwachukwu, and Afolabi B. Abiodun. "Usefulness of Chlamydia serology in prediction of tubal factor infertility among infertile patients at Federal Medical Centre, Bida, North Central Nigeria." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 8, no. 2 (January 25, 2019): 412. http://dx.doi.org/10.18203/2320-1770.ijrcog20190261.
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Background: Infertility is a major public health problem in developing countries where pelvic inflammatory disease due mainly to Chlamydia trachomatis and Neisseria gonorrhea infection have been implicated. The role of Chlamydia serology in predicting tubal factor infertility (TFI) has been demonstrated by many researchers elsewhere. However, there are limited data in our environment. This prospective cross-sectional study aims to determine the usefulness of Chlamydia Serology as a screening tool for TFI at Federal Medical Centre, Bida, North Central Nigeria.Methods: 125 women with infertility who met the inclusion criteria were enrolled into the study. Relevant information on their socio-demographic characteristics, gynaecological symptoms and risks factors for infertility were obtained. Participants had Hysterosalpingography (HSG) as part of their fertility work-up while 5ml of venous blood was withdrawn to check for Immunoglobulin G antibody to Chlamydia trachomatis using rapid test kits. The HSG findings were correlated with the result of Chlamydia serology. Data was analyzed using the computer software, Statistical Package for Social Science (SPSS) version 20. The level of significance (p value) was set at 0.05.Results: A total of 120 infertile women completed the study, 5 had incomplete investigations and were excluded from the analysis. The prevalence of TFI was 47.5%, while that of positive chlamydia serology was 36.5%. The prevalence of chlamydial seropositivity was 59.6% for patients with TFI but 15.9% for non-TFI. There was a significant association between positive chlamydia serology and TFI p< 0.05. The study revealed moderate sensitivity 59.6%, and negative predictive value 69.7% but high specificity 84.1% and positive predictive value of 77.2%. In this study the odds for diagnosing tubal infertility was 7.8.Conclusions: Chlamydia serology is useful in predicting TFI and should be incorporated in the routine work up for infertility.
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Zhang, Ying, and Maria L. Dufau. "EAR2 and EAR3/COUP-TFI Regulate Transcription of the Rat LH Receptor." Molecular Endocrinology 15, no. 11 (November 1, 2001): 1891–905. http://dx.doi.org/10.1210/mend.15.11.0720.
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Abstract Our previous studies demonstrated regulation of the human LH receptor (hLHR) promoter by nuclear orphan receptors EAR2, EAR3/COUP-TFI (repression), and TR4 (activation) through a direct-repeat motif (hDR). The current studies investigated the differential binding of orphan receptors to rat (rLHR) and hLHR promoters, and their modulation of rLHR gene transcription in rat granulosa cells. The rLHR DR with one nucleotide difference from hDR at its core sequence mediated inhibition of the rLHR transcription, to which EAR2 and EAR3/COUP-TFI but not TR4 bound. The A/C mismatch was responsible for the lack of TR4 binding and function, but had no effect on EAR2 and EAR3/COUP-TFI. EAR2 and EAR3/COUP-TF bound to the rLHR DR with lower affinity than to the hDR, and exhibited lesser inhibitory capacity. This difference resulted from the lack of a guanine in the rDR, which is present 3′ next to the hDR core. These studies have identified sequence-specific requirements for the binding of EAR2, EAR3/COUP-TFI, and TR4 to the DRs that explain their differential regulation of rat and human LHR genes. In addition, hCG treatment significantly reduced the inhibition of rLHR gene in granulosa cells and also decreased EAR2 and EAR3/COUP-TFI protein levels. These results indicate that hormonally regulated expression of EAR2 and EAR3/COUP-TFI contributes to gonadotropin-induced derepression of LHR promoter activity in granulosa cells.
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Sridhar, Srikala S., Thomas Powles, Yohann Loriot, Miguel A. Climent Durán, Shilpa Gupta, Norihiko Tsuchiya, Aristotelis Bamias, et al. "Avelumab first-line (1L) maintenance for advanced urothelial carcinoma (UC) in the JAVELIN Bladder 100 trial: Subgroup analysis by duration of treatment-free interval (TFI) from end of chemotherapy to start of maintenance." Journal of Clinical Oncology 39, no. 15_suppl (May 20, 2021): 4527. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.4527.
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4527 Background: The phase 3 JAVELIN Bladder 100 trial, which enrolled patients (pts) with advanced UC that had not progressed with 1L platinum-containing chemotherapy, showed that maintenance therapy with avelumab + best supportive care (BSC) significantly prolonged overall survival (OS) compared with BSC alone (hazard ratio [HR], 0.69 [95% CI: 0.56, 0.86; 1-sided P= 0.0005]). However, the optimal timing for starting avelumab after completing 1L chemotherapy is unknown. In this post hoc analysis, we report efficacy by duration of the TFI from completion of 1L chemotherapy. Methods: In the JAVELIN Bladder 100 trial (NCT02603432), eligible pts had unresectable locally advanced or metastatic UC without disease progression following 4 to 6 cycles of 1L platinum-containing chemotherapy. Pts were randomized to receive avelumab + BSC (n = 350) or BSC alone (n = 350) after a TFI of 4 to 10 weeks from the last dose of chemotherapy. In this exploratory analysis, subgroups with a TFI of 4 to < 6 weeks ( < 42 days), 6 to < 8 weeks (42 to < 56 days), or 8 to 10 weeks (≥56 days) were evaluated. Results: In the avelumab + BSC and BSC alone arms, the TFI was 4 to < 6 weeks in 143 and 158 pts, 6 to < 8 weeks in 109 and 80 pts, and 8 to 10 weeks in 98 and 110 pts, respectively. Baseline characteristics in these subgroups were generally well balanced between arms. For both arms combined, however, the TFI 4 to < 6 weeks subgroup vs the other 2 subgroups included more pts with visceral metastases (57.8% vs 54.0% and 50.0%), an objective response with 1L chemotherapy (76.4% vs 69.3% and 68.3%), and an ECOG performance status of 1 (44.5% vs 33.3% and 35.6%). OS was prolonged with avelumab + BSC vs BSC alone in all subgroups; the HR was 0.76 (95% CI: 0.546, 1.059) in the TFI 4 to < 6 weeks subgroup (median OS, 19.9 months [95% CI: 16.3, 25.3] vs 13.5 months [95% CI: 11.7, 17.4]), 0.64 (95% CI: 0.404, 1.021) in the TFI 6 to < 8 weeks subgroup (median OS, 26.1 months [95% CI: 19.9, not estimable] vs 21.0 months [95% CI: 10.7, not estimable]), and 0.70 (95% CI: 0.468, 1.035) in the TFI 8 to 10 weeks subgroup (median OS, 20.1 months [95% CI: 13.8, not estimable] vs 14.1 months [95% CI: 11.7, 19.6]). Conclusions: In patients with advanced UC that had not progressed with 1L platinum-containing chemotherapy, avelumab 1L maintenance prolonged OS irrespective of the TFI assessed in this study (4-10 weeks), supporting this new treatment strategy as a standard of care. Differences in duration of TFI were likely related to individual patient- and disease-specific characteristics or logistics and did not impact the OS benefit observed with avelumab 1L maintenance. Clinical trial information: NCT02603432.
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Morilla, Alison, David Gonzalez, Ilaria Del Giudice, Ricardo Morilla, Estella Matutes, Claire Dearden, Daniel Catovsky, and Gareth Morgan. "Combinations of ZAP-70, CD38 and IgVH Mutational Status as Predictors of Time to First Treatment in CLL." Blood 106, no. 11 (November 16, 2005): 711. http://dx.doi.org/10.1182/blood.v106.11.711.711.
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Abstract The prognostic value of ZAP-70, CD38 expression and IgVH somatic hypermutation(SHM) in CLL has been well documented. We investigated whether the proposed model of combining ZAP-70 and CD38 levels to identify patients likely to progress (Del Giudice et al 2005, Schroers et al 2005) remained valid when mutational status was considered and studied which combinations of these 3 parameters provided the most valuable prognostic information. ZAP-70 and CD38 were evaluated by flow cytometry and IgVH SHM was analysed by direct sequencing with 98% cut off. All 3 parameters were studied in 115 untreated CLL patients, 90% of which were advanced stage:(stage A stable 10%, stage A progressive 30%, stage B 37%, and stage C 23%). ZAP-70 and IgVH SHM showed 68% concordance, CD38 and IgVH SHM concordance of 69% and 75% of patients, using cut offs of ≥30% and ≥7%, respectively. The impact on time to first treatment /treatment free interval (TFI) for these parameters can be seen in Table 1. Treatment Free Interval (TFI )and Prognostic Factors No.of Cases Median TFI (months) P Value TFI=Time from diagnosis to date of first treatment Mutational status Umutated 68 23 0.00003 Mutated 47 61 ZAP70 ≥20% Positive 37 24 0.00055 Negative 78 44 CD38 ≥7% Positive 79 25 0.0005 Negative 36 61 Mutation/ZAP70 ZAP70+/Unmutated 35 19 0.002 Discordants 36 25 ZAP70-/Mutated 44 64 Mutation/CD38 ≥7% CD38+/unmutated 59 21 0.004 Discordants 29 37 CD38-/Mutated 27 77 ZAP70/CD38 ≥7% ZAP70+/CD38+ 34 19 0.003 Discordants 48 39 ZAP70-/CD38- 33 72 Mutation/ZAP70/CD38 ≥7% ZAP70+/CD38+/Unmutated 32 20 0.007 Discordants 57 30 ZAP70-/CD38-/Mutated 26 75 Univariate analysis showed significance for TFI, for each variable. Regardless of the combinations used, 2 or all 3 variables provided significant prognostic information with respect to TFI. An intermediate prognostic group was identified for discordant cases. CD38 ≥7% proved a more significant value than ≥30% for this series, hence this cut off was used for subsequent analysis. IgVH SHM/CD38 provided the best discrimination between favourable and unfavourable prognostic groups, in relation to TFI, with the least number of discordants. Concordant cases of CD38+/ZAP70+ were able to positively predict unmutated status in 94.1% of cases and ZAP70-/CD38- cases predicted mutated status in 78.8% of patients. The discordant ZAP70/CD38 cases could be further stratified by testing IgVH SHM (mutated cases median TFI: 42 m, unmutated cases median TFI: 19 m). Amongst the cases discordant for ZAP/CD38/IgVH SHM, the largest group (40%), was ZAP70 -/CD38+ /unmutated and showed median TFI:25m, comparable to the worst prognostic group for all combinations. There was no evidence of preferential IgVH gene usage in this discordant group. In conclusion we have shown that combining IgVH SHM/CD38 provides more refined prediction of TFI in this group. Combination of ZAP-70 and CD38 is useful for predicting time to first treatment without the need for IgVH SHM analysis, in concordant cases. Thus these simple tests( ZAP-70 and CD38), performed by flow cytometry continue to provide relevant prognostic information,although IgVH SHM is still the paradigm.
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Wang, Yueli, Yulin Li, Yina Wu, Lixin Jia, Jijing Wang, Bo Xie, Mizhou Hui, and Jie Du. "5TNF-α and IL-1β Neutralization Ameliorates Angiotensin II-Induced Cardiac Damage in Male Mice." Endocrinology 155, no. 7 (July 1, 2014): 2677–87. http://dx.doi.org/10.1210/en.2013-2065.
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Inflammation is a key event in hypertensive organ damage, and TNF-α and IL-1β are elevated in hypertension. In this study, we evaluated the effects of TNF-α and IL-1β elevation on hypertensive cardiac damage by treatment with a bifunctional inflammatory inhibitor, TNF receptor 2-fragment crystalization-IL-1 receptor antagonist (TFI), which can neutralize these 2 cytokines simultaneously. A mouse hypertension model of angiotensin II (Ang II) infusion (1500 ng/kg·min for 7 d) was induced in wild-type mice. TNF-α and IL-1β were inhibited by TFI administration (5 mg/kg, every other day), the effects of inhibition on cardiac damage were examined, and its mechanism on inflammatory infiltration was further studied in vivo and in vitro. Ang II infusion induced cardiac injury, including increased macrophage infiltration, expression of inflammatory cytokines (IL-12, IL-6, etc), and cardiac fibrosis, such as elevated α-smooth muscle actin, collagen I, and TGF-β expression. Importantly, the Ang II-induced cardiac injury was suppressed by TFI treatment. Moreover, TFI reduced the expression of adhesion molecules (intercellular adhesion molecule-1 and vascular cell adhesion molecule-1) and monocyte chemotactic protein-1 expression in Ang II-treated hearts. Additionally, blockade of TNF-α and IL-1β by TFI reduced monocyte adherence to endothelia cell and macrophage migration. This study demonstrates that blocking TNF-α and IL-1β by TFI prevents cardiac damage in response to Ang II, and targeting these 2 cytokines simultaneously might be a novel tool to treat hypertensive heart injury.
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Sawasdipanich, Nantaga, Supa Puektes, Supaporn Wannasuntad, Ankana Sriyaporn, Chulepon Chawmathagit, Jirapa Sintunava, and Gamjad Paungsawad. "Development of healthcare facility standards for Thai female inmates." International Journal of Prisoner Health 14, no. 3 (September 10, 2018): 163–74. http://dx.doi.org/10.1108/ijph-07-2017-0032.
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Purpose The purpose of this paper is to develop and evaluate the Standards of Healthcare Facility for Thai Female Inmates (SHF-TFI) through healthcare service improvement. Design/methodology/approach This research and quality improvement project was comprised of three phases. Surveying healthcare facilities and in-depth interviews with female inmates as well as prison nurses were employed in Phase I. Expert reviews and public hearing meetings were used for developing the SHF-TFI in Phase II. Satisfaction questionnaires, focus group interviews of the female inmates, and in-depth interviews with nurses and prison wardens were utilized to evaluate feasibility and effectiveness of SHF-TFI implementation in Phase III. Findings The SHF-TFI was elaborated in order to be more specific to the context of the correctional institutes and correspond with healthcare as to the needs of female inmates. It was divided into three main aspects: administrative standards, health service standards and outcome standards. After implementation, nurses reflected on the feasibility and benefits of the SHF-TFI on the organizations, inmates and nurses. The female inmates perceived remarkable improvement in the healthcare services including physical activity promotion and screening programs for non-communicable diseases, the physical environment and sufficiency of medical equipment. Moreover, the pregnant inmates and incarcerated mothers with children shared their views on better antenatal and child developmental care, as well as availability of baby supplies. Originality/value The findings support the feasibility and effectiveness of the SHF-TFI for quality care improvement and applicability of the Bangkok Rules in women’s correctional institutes.
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Viganò, Maria G., Vanesa Gregorc, Domenico Ghio, Alessandra Bulotta, Gilda Rossoni, Claudio Sallemi, Scialini Colombi, Gloria Rossoni, Antonio Lambiase, and Claudio Bordignon. "Treatment-free interval (TFI) after first-line therapy (FLT) and disease control rate (DCR) on second-line therapy (SLT): Impact on overall survival (OS) in relapsed malignant pleural mesothelioma (MPM)." Journal of Clinical Oncology 31, no. 15_suppl (May 20, 2013): e18528-e18528. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e18528.
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e18528 Background: Both TFI (the time elapsing from FLT completion to SLT initiation) and DCR (the rate of nonprogression at first tumor evaluation) have been found to predict OS in other tumor types. Methods: The impact on outcome of TFI after FLT and DCR on SLT was tested in an individual patient pooled analysis of 261 MPM patients (pts) who had radiologic progressive disease (PD) after a pemetrexed-based FLT before entering a ph 2 trial with single-agent NGR-hTNF (n=50) and a ph 3 trial with single-agent gemcitabine, vinorelbine or doxorubicin plus NGR-hTNF/placebo (n=211). In both trials, response to SLT was assessed every 6 weeks by MPM-modified RECIST. Progression-free survival (PFS) and OS were computed from SLT start. By ROC analysis, the cutpoint for estimating TFI in relation to OS was set at 6 months (AUC=0.59; p=.009). Results: After FLT, 60 pts (23%) had partial response (PR), 135 (52%) stable disease (SD), for a DCR of 75%, and 66 (25%) early PD. Median time to PD was 7.0 months (95% CI, 6.2-7.4) and median TFI was 4.4 months (3.8-5.0), with 97 pts (37%) having a TFI > 6 months. Among baseline factors (age, sex, PS and histology) used in logistic regression, only younger age was related to higher odds to attain a TFI > 6 months (OR=1.9; 95% CI, 1.2-3.3). A TFI > 6 months (vs ≤ 6) was weakly related to DCR (Spearman's r=0.16; p=.01) and strongly associated with longer PFS and OS, with HR of 0.48 (0.36-0.65) and 0.59 (0.42-0.83), respectively. After SLT, 9 pts (3%) had PR, 130 (50%) SD, for a DCR of 53%, and 122 (47%) early PD. Of 60 pts responding to FLT, 23 (38%) progressed early on SLT, while of 66 pts progressing early during FLT, 32 (48%) experienced disease control on SLT. Baseline factors did not relate with DCR at week 6. On landmark analysis set at the 6-week time point, DCR (vs PD) was associated with OS benefit (HR=0.46; 0.32-0.65), which persisted after adjusting for baseline factors (HR=0.40; 0.27-0.57). Conclusions: With a smaller HR, an early-look measure such as 6-week DCR on SLT shows some advantage over TFI after FLT in predicting subsequent OS. In relapsed MPM, TFI as stratification factor and DCR as surrogate endpoint may be considered. Clinical trial information: NCT00484276-NCT01098266.
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Malogajski, Jelena, Ivan Branković, Jolande A. Land, Pierre P. M. Thomas, Servaas A. Morré, and Elena Ambrosino. "The Potential Role for Host Genetic Profiling in Screening for Chlamydia-Associated Tubal Factor Infertility (TFI)—New Perspectives." Genes 10, no. 6 (May 28, 2019): 410. http://dx.doi.org/10.3390/genes10060410.
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Host immunogenetic factors can affect late complications of urogenital infections with Chlamydia trachomatis. These findings are creating new avenues for updating existing risk prediction models for C. trachomatis-associated tubal factor infertility (TFI). Research into host factors and its utilization may therefore have future implications for diagnosing C. trachomatis-induced infertility. We outline the epidemiological situation regarding C. trachomatis and TFI in high-income countries. Thereupon, we review the main characteristics of the population undergoing fertility work-up and identify screening and diagnostic strategies for TFI currently in place. The Netherlands is an exemplary model for the state of the art in high-income countries. Within the framework of existing clinical approaches, we propose a scenario for the translation of relevant genome-based information into triage of infertile women, with the objective of implementing genetic profiling in the routine investigation of TFI. Furthermore, we describe the state of the art in relevant gene- and single nucleotide polymorphism (SNP) based clinical prediction models and place our perspectives in the context of these applications. We conclude that the introduction of a genetic test of proven validity into the assessment of TFI should help reduce patient burden from invasive and costly examinations by achieving a more precise risk stratification.
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Rantsi, Tiina, Jolande A. Land, Päivi Joki-Korpela, Sander Ouburg, Kati Hokynar, Jorma Paavonen, Aila Tiitinen, and Mirja Puolakkainen. "Predictive Values of Serum Chlamydia trachomatis TroA and HtrA IgG Antibodies as Markers of Persistent Infection in the Detection of Pelvic Adhesions and Tubal Occlusion." Microorganisms 7, no. 10 (September 25, 2019): 391. http://dx.doi.org/10.3390/microorganisms7100391.
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Chlamydia trachomatis IgG antibody testing (CAT) has been used as a screening test for tubal factor infertility (TFI), but as the CAT is only a marker of a past exposure to C. trachomatis and not of late sequelae, the positive predictive value (PPV) of the test is low. The persistence of C. trachomatis in the upper genital tract has been suggested as one of the key mechanisms in the development of TFI. Serum antibodies against C. trachomatis TroA and HtrA, proteins expressed specifically during persistent infection, have been suggested as novel biomarkers for TFI diagnostics. We studied serum IgG antibody responses against C. trachomatis TroA, HtrA and MOMP in 79 subfertile women, of whom 28 had laparoscopically proven TFI. We confirmed that the accuracy of CAT in diagnosing TFI is low, whereas TroA IgG and HtrA IgG are more accurate tests in detecting tubal occlusion and pelvic adhesions. However, the sensitivity and negative predictive value (NPV) of TroA IgG and HtrA IgG are still too low to justify their use as a screening test in clinical practice. Individual immunogenetic profiles combined with TroA and HtrA antibody responses might identify women with the highest risk for developing late complications after C. trachomatis infection.
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Segev, Fani, Noa Geffen, Anat Galor, Yoel Cohen, Raanan Gefen, Avner Belkin, Yoel Arieli, Shlomi Epshtein, Anat Oren, and Alon Harris. "Dynamic assessment of the tear film muco-aqueous and lipid layers using a novel tear film imager (TFI)." British Journal of Ophthalmology 104, no. 1 (April 18, 2019): 136–41. http://dx.doi.org/10.1136/bjophthalmol-2018-313379.
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PurposeThe objective of the study was to assess a new technology, the tear film imager (TFI), which can dynamically image the muco-aqueous and lipid layers.MethodsProspective pilot case series of individuals with and without dry eye (DE). Two sequential images were obtained with the TFI. Measurements were assessed for reproducibility and compared with clinically derived DE metrics. Individuals were grouped into DE categories based on signs of DE.Results49 patients participated in the study with a mean age of 58.8 years (SD 15.9) and a female majority (69%). Reproducibility of the muco-aqueous layer thickness (MALT) was excellent (r=0.88). MALT measurements significantly correlated with the Schirmer score (r=0.31). Lipid break up time (LBUT) as measured by the TFI significantly correlated with the clinical measure of tear break up time (TBUT) (r=0.73). MALT and LBUT were significantly thinner and shorter, respectively, in the DE groups (mild–moderate and severe) compared with the control group. When comparing TFI parameters to clinically assessed signs, sensitivity of the device was 87% and specificity was 88%.ConclusionThe TFI is the first machine capable of reproducibly measuring muco-aqueous thickness in human subjects which correlates with Schirmer score. In parallel, it assesses other important aspects of tear film function which correlate with clinician assessed DE metrics.
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Massar, Michelle M., Kent McIntosh, and Sterett H. Mercer. "Factor Validation of a Fidelity of Implementation Measure for Social Behavior Systems." Remedial and Special Education 40, no. 1 (October 28, 2017): 16–24. http://dx.doi.org/10.1177/0741932517736515.
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Assessing fidelity of implementation of school-based interventions is a critical factor in successful implementation and sustainability. The Tiered Fidelity Inventory (TFI) was developed as a comprehensive measure of all three tiers of School-Wide Positive Behavioral Interventions and Supports (SWPBIS) and is intended to measure the extent to which the core features of SWPBIS are implemented with fidelity. The purpose of this study was to assess the extent to which the TFI can be used as one measure of all three tiers, three separate measures of individual tiers, or as a more granular level of fidelity that measures implementation on 10 subscales across the tiers. A confirmatory factor analysis was conducted to validate the factor structure of the TFI. Results indicate that the TFI is a valid measure of fidelity of implementation of SWPBIS and can be used to measure implementation by subscales, tiers, and as a comprehensive assessment of all three tiers.
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Chandra, Navshika, Kevin Chang, Arier Lee, Giriraj S. Shekhawat, and Grant D. Searchfield. "Psychometric Validity, Reliability, and Responsiveness of the Tinnitus Functional Index." Journal of the American Academy of Audiology 29, no. 07 (July 2018): 609–25. http://dx.doi.org/10.3766/jaaa.16171.
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AbstractThe effects of treatments on tinnitus have been difficult to quantify. The Tinnitus Functional Index (TFI) has been proposed as a standard questionnaire for measurement of tinnitus treatment outcomes. For a questionnaire to achieve wide acceptance, its psychometric properties need to be confirmed in different populations.To determine if the TFI is a reliable and valid measure of tinnitus, and if its psychometric properties are suitable for use as an outcome measure.A psychometric evaluation of the TFI from secondary data obtained from a cross-sectional clinic survey and a clinical trial undertaken in New Zealand.Confirmatory factor analysis and evaluation of internal consistency reliability were undertaken on a sample of 318 patients with the primary complaint of tinnitus. In a separate sample of 40 research volunteers, test–retest reliability, convergent and divergent validity were evaluated. Both samples consisted of predominantly older Caucasian male patients with tinnitus.The internal structure of the original US TFI was confirmed. The Cronbach’s Alpha and Intraclass correlation coefficients were >0.7 for the TFI overall and each of its subscales, indicating high internal consistency and test–retest reliability. Strong Pearson correlations with the Tinnitus Handicap Questionnaire and tinnitus numerical rating scales indicated excellent convergent validity, and a moderate correlation with the Hearing Handicap Inventory, indicated moderate divergent validity. Evaluation of the clinical trial showed good test–retest reliability and agreement between no-treatment baselines with a smallest detectable change of 4.8 points.The TFI is a reliable and valid measure of tinnitus severity in the population tested and is responsive to treatment-related change. Further research as to the TFI’s responsiveness to treatment is needed across different populations.
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Kim, Bora, Tae-Kyeong Lee, Cheol Woo Park, Dae Won Kim, Ji Hyeon Ahn, Hyejin Sim, Jae-Chul Lee, et al. "Pycnogenol® Supplementation Attenuates Memory Deficits and Protects Hippocampal CA1 Pyramidal Neurons via Antioxidative Role in a Gerbil Model of Transient Forebrain Ischemia." Nutrients 12, no. 8 (August 17, 2020): 2477. http://dx.doi.org/10.3390/nu12082477.
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Pycnogenol® (an extract of the bark of French maritime pine tree) is used for dietary supplement and known to have excellent antioxidative efficacy. However, there are few reports on neuroprotective effect of Pycnogenol® supplementation and its mechanisms against ischemic injury following transient forebrain ischemia (TFI) in gerbils. Now, we examined neuroprotective effect and its mechanisms of Pycnogenol® in the gerbils with 5-min TFI, which evokes a significant death (loss) of pyramidal cells located in the cornu ammonis (CA1) region of gerbil hippocampus from 4–5 days post-TFI. Gerbils were pretreated with 30, 40, and 50 mg/kg of Pycnogenol® once a day for 7 days before TFI surgery. Treatment with 50 mg/kg, not 30 or 40 mg/kg, of Pycnogenol® potently protected learning and memory, as well as CA1 pyramidal cells, from ischemic injury. Treatment with 50 mg/kg Pycnogenol® significantly enhanced immunoreactivity of antioxidant enzymes (superoxide dismutases and catalase) in the pyramidal cells before and after TFI induction. Furthermore, the treatment significantly reduced the generation of superoxide anion, ribonucleic acid oxidation and lipid peroxidation in the pyramidal cells. Moreover, interestingly, its neuroprotective effect was abolished by administration of sodium azide (a potent inhibitor of SODs and catalase activities). Taken together, current results clearly indicate that Pycnogenol® supplementation can prevent neurons from ischemic stroke through its potent antioxidative role.
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Pobrotyn, Piotr, Aleksandra Pasieczna, Dorota Diakowska, Bartosz Uchmanowicz, Grzegorz Mazur, Mirosław Banasik, and Aleksandra Kołtuniuk. "Evaluation of Frailty Syndrome and Adherence to Recommendations in Elderly Patients with Hypertension." Journal of Clinical Medicine 10, no. 17 (August 24, 2021): 3771. http://dx.doi.org/10.3390/jcm10173771.
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Frailty syndrome (FS) often coexists with many diseases of the elderly, including arterial hypertension, and may affect the disease course and adherence to therapeutic recommendations. This study aimed to evaluate the relationship between frailty and adherence to therapeutic recommendations in elderly hypertensive patients. The study included 259 patients hospitalized between January 2019 and November 2020 due to exacerbation of hypertension symptoms. Medical records were used to obtain basic sociodemographic and clinical data. The study was based on the Tilburg Frailty Indicator (TFI) and the Hill–Bone Scale (HBCS). The obtained data were analyzed within a cross-sectional design. The mean frailty score indicated by the TFI questionnaire was 7.09 ± 3.73. The most prominent FS component was associated with the physical domain (4.24 ± 2.54). The mean overall adherence measured with the HBCS was 20.51 ± 3.72. The linear regression model testing the Hill–Bone “reduced sodium intake” score against the TFI domains showed no relationships between the variables. Another regression model for the Hill–Bone “appointment-keeping” subscale indicated significant predictors for physical and social TFI domains (p = 0.002 and p < 0.0001, respectively). For the Hill–Bone “taking antihypertensive drugs” variable, the regression model found significant relationships with all TFI domains: physical (p < 0.0001), psychological (p = 0.003) and social (p < 0.0001). Our study suggests that frailty in patients with arterial hypertension can negatively impact their adherence to therapeutic recommendations.
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Li, Hui, Xiaofeng Liu, and Lin Bo. "Fault Identification of Rotor System Based on Classifying Time-Frequency Image Feature Tensor." International Journal of Rotating Machinery 2017 (2017): 1–12. http://dx.doi.org/10.1155/2017/6542348.
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In the field of rotor fault pattern recognition, most of classical pattern recognition methods generally operate in feature vector spaces where different feature values are stacked into one-dimensional (1D) vector and then processed by the classifiers. In this paper, time-frequency image of rotor vibration signal is represented as a texture feature tensor for the pattern recognition of rotor fault states with the linear support higher-tensor machine (SHTM). Firstly, the adaptive optimal-kernel time-frequency spectrogram visualizes the unique characteristics of rotor fault vibration signal; thus the rotor fault identification is converted into the corresponding time-frequency image (TFI) pattern recognition. Secondly, in order to highlight and preserve the TFI local features, the TFI is divided into some TFI subzones for extracting the hierarchical texture features. Afterwards, to avoid the information loss and distortion caused by stacking multidimensional features into vector, the multidimensional features from the subzones are transformed into a feature tensor which preserves the inherent structure characteristic of TFI. Finally, the feature tensor is input into the SHTM for rotor fault pattern recognition and the corresponding recognition performance is evaluated. The experimental results showed that the method of classifying time-frequency texture feature tensor can achieve higher recognition rate and better robustness compared to the conventional vector-based classifiers, especially in the case of small sample size.
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Power, S. C., and S. Cereghini. "Positive regulation of the vHNF1 promoter by the orphan receptors COUP-TF1/Ear3 and COUP-TFII/Arp1." Molecular and Cellular Biology 16, no. 3 (March 1996): 778–91. http://dx.doi.org/10.1128/mcb.16.3.778.
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vHNF1 (also termed HNF1 beta) is a member of the hepatocyte nuclear fa ctor 1 (HNF1; also termed HNF1 alpha) family of homeodomain-containing transcription factors that interact with a sequence motif found in the regulatory regions of a large number of genes expressed mainly in the liver. It has been suggested that vHNF1 plays a role in early differentiation of specialized epithelia of several endoderm- and mesoderm-derived organs, with HNF1 playing a role in later stages. In support of this idea, expression of vHNF1 but not HNF1 is induced upon treatment of the embryonal carcinoma cell line F9 with retinoic acid. We have cloned and analyzed the vHNF1 promoter to gain a better understanding of the regulation of vHNF1 expression and how it relates to the expression of HNF1. We have identified five sites of DNA-protein interaction within the first 260 bp upstream of the transcription start site, which involve at least three different families of transcription factors. Two sites, a distal DR-1 motif and a proximal octamer motif, are the most important for promoter activity. The DR-1 motif interacts with several members of the steroid hormone receptor superfamily including HNF4, COUP-TFI/Ear3, COUP-TFII/Arp1, and RAR alpha/RXR alpha heterodimers. The vHNF1 promoter is transactivated by COUP-TFI/Ear3 and COUP-TFII/Arp1 and, unlike the HNF1 promoter, is virtually unaffected by HNF4. Interestingly, the proximal octamer site and not the DR-1 site is required for COUP-TFI/Ear3 and COUP-TFII/Arp1 transactivation of the vHNF1 promoter. COUP-TFI/Ear3 does not bind directly to this proximal octamer site. We present evidence of an interaction between COUP-TFI/Ear3 and the octamer-binding proteins in vitro and in the cell, suggesting that COUP-TFI and COUP-TFII activate the vHNF1 promoter via an indirect mechanism.
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Davis, Ashlee W., Ronald F. Levant, and Shana Pryor. "Traditional Femininity Versus Strong Black Women Ideologies and Stress Among Black Women." Journal of Black Studies 49, no. 8 (September 5, 2018): 820–41. http://dx.doi.org/10.1177/0021934718799016.
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The construct of femininity has typically been conceptualized from a Eurocentric perspective as traditional femininity ideology (TFI). This hegemonic femininity construction might not be fully applicable to African American women given their unique history and experiences. Moreover, the strong Black woman ideology (SBWI) which, although formulated during slavery, has become an adaptive and idealized cultural idealization. Both constructs have been associated with stress. The current study sought to investigate the relative strength of the links between TFI versus SBWI and perceived stress among a sample of African American women, and whether these relationships were moderated by feminine gender role stress and racial stress. Participants were 292 African American women recruited via social media and students from a Midwestern university for a web-based survey. As hypothesized, SBWI accounted for unique variance in perceived stress; however, TFI did not explain any of the variance. Results also indicated that gender role stress approached significance in its moderation of the link between TFI and perceived stress, although racial stress did significantly moderate the relationship between SBWI and perceived stress.
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Mirza, M. R., B. Lund, K. Bertelsen, J. Lindegaard, N. Keldsen, A. Mellemgaard, and R. Depont. "Pegylated liposomal doxorubicin (PLD) and gemcitabine (GEM) in combination in the salvage treatment of epithelial ovarian cancer (OC)—a Danish Gynaecologic Cancer Group (DGC) study." Journal of Clinical Oncology 24, no. 18_suppl (June 20, 2006): 5094. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.5094.
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5094 Background: Ovarian cancer patients (pts) recurring with a short treatment-free interval (TFI) after prior chemotherapy (PCT) have a bad prognosis. DGC has conducted a phase II study of PLD-GEM in combination in OC pts recurring with a TFI of less than 12 months (mo). Methods: All pts must have received at least one platinum-paclitaxel containing regimen; no PCT with GEM or anthracyclines. Regimen: GEM 800mg/m2 day 1+8 and PLD 25mg/m2 day 1, q 21 days. GEM dose escalation to 1g/m2 day 1+8 from 2. cycle in the absence of grade 3–4 toxicity. Primary end point: OS, secondary: PFS, response and toxicity. Pts were grouped according to their response to PCT. Group 1: pts with CR on PCT and TFI 3–12 mo; group 2: pts with CR on PCT and TFI 0–3 mo; group 3: pts with PR/SD on PCT and TFI 0–12 mo. 35 pts with ≥2 prior number of treatments. Results: 82 pts were enrolled (May 2003-Aug 2005); the median age was 59 yrs (range 31 to 77 yrs); 15 pts were entered with rising CA125 only (GCIG criteria). Groups according to their response to PCT: group 1: 44 pts; group 2: 5 pts; group 3: 33 pts. TFI ≤ 6 mo 33 pts, TFI > 6 to ≤ 12 mo 49 pts. To date data on 330 cycles (mean 4.7 cycles) is available; 45 pts are evaluable for PFS and OS; 62 pts are evaluable for response and 71 pts for toxicity. Grade 3–4 toxicity: PPE 6/330 cycles; mucosites 8/330 cycles; febrile neutropenia 4%; treatment delay 9%. No dose reductions performed for PLD. GEM dose escalation to 1000 mg/m2 in 31 pts; dose reduction to 650 mg/m2 at any time in 21 pts; skipped dose day 8 in 44 cycles. Response (RESIST): CR 3 pts; PR 17 pts (CR+PR 32%); SD 39 pts; PD 2 pts. Median PFS 212 days, Median OS 234 days. Conclusions: PLD-GEM in combination in the salvage setting is well tolerated, with acceptable toxicity and clear activity. No significant financial relationships to disclose.
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Gandy, Joan, Homero Martinez, Isabelle Guelinckx, Luis A. Moreno, Saptawati Bardosono, Jordi Salas-Salvadó, and Stavros A. Kavouras. "Relevance of Assessment Methods for Fluid Intake." Annals of Nutrition and Metabolism 68, Suppl. 2 (2016): 1–5. http://dx.doi.org/10.1159/000446197.
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Reliable data at population level are essential to firmly establish links between fluid intake, hydration and health, investigate dose-response relationships and develop meaningful public health strategies or reference intake values. However, limited research exists regarding the most appropriate methodology for assessing beverage or total fluid intake (TFI). To date, methodologies have been developed to assess food and nutrient intake without due consideration of water or fluid intake behavior. A recent crossover study showed that a 24-hour food recall significantly underestimated mean TFI by 382 ml (95% CI 299-465) compared with a fluid specific 7-day record. The authors postulated that this average difference was mainly the result of missed drinking acts between meals a 24-hour recall was used. Using a 7-day record administered in paper form or on-line has also been shown to lead to a significantly different mean TFI of 129 ml. Therefore, the choice of methodology might result in measurement errors that limit between-survey or between-country comparisons. Such errors may contribute to variations in estimates of TFI that cannot be explained by differences in climate, physical activity or cultural habits. A recent survey confirmed the variation in methodologies used in European national dietary surveys. Since these surveys form the basis for setting adequate intakes for total water intake, measurement error between surveys should be limited, highlighting the need for the development of a consistent methodology that is validated for water and TFI estimation.
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Shepherd, Gary, and Gordon Shepherd. "Reboot of The Family International." Nova Religio 17, no. 2 (February 2013): 74–98. http://dx.doi.org/10.1525/nr.2013.17.2.74.
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Since its founding in 1968, The Family International (TFI) has been an important case study for social science investigation of new religious movements. Its persistence and adaptive organizational development throughout the world, in spite of periodically strong social opposition, initially suggested a long and increasingly stable career ahead. However, in 2009, TFI leaders announced a dramatic shift in belief, practice, and organization, which they termed The Reboot. As a consequence, most of the structures and previous functioning of TFI as a visible organization have been dismantled, leading to questions about the group’s future viability. This article summarizes the changes that have taken place, suggests some of the reasons for these, and assesses TFI’s prospects for continued existence in the new form it has assumed.
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Doñate-Martínez, Ascensión, Tamara Alhambra-Borrás, and Estrella Durá-Ferrandis. "Frailty as a Predictor of Adverse Outcomes among Spanish Community-Dwelling Older Adults." International Journal of Environmental Research and Public Health 19, no. 19 (October 5, 2022): 12756. http://dx.doi.org/10.3390/ijerph191912756.
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Spain is one of the European countries with the oldest populations. The prevalence of frailty among Spanish older people ranges from 8.4 to 29.4% and currently, is one of the most relevant public health challenges. The Tilburg Frailty indicator (TFI) has been widely used in the community and in healthcare settings for assessing frailty. The objective of this study is to evaluate the predictive performance of the TFI for several adverse outcomes among Spanish community-dwelling older adults. The predictive performance was tested through linear regression analyses and receiver operating characteristics (ROC) curves. A total of 552 Spanish older adults composed the study sample. Participants were assessed at baseline and after 6 months. Main results showed that frailty was strongly and significantly correlated with disability, physical health, mental health and falls efficacy. The TFI score predicted most of these adverse outcomes. The ROC analyses confirmed the acceptable predictive performance of the total frailty. This study provides new evidence confirming that the TFI is a valid tool to predict several adverse outcomes in Spanish older adults, which may allow professionals to plan and activate health and social care resources to support frail patients’ needs.
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Coelho, T., C. Paúl, and L. Fernandes. "Comparison of the frailty phenotype and the Tilburg Frailty Indicator regarding the prediction of quality of life in a two-year follow-up." European Psychiatry 33, S1 (March 2016): S185. http://dx.doi.org/10.1016/j.eurpsy.2016.01.405.
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IntroductionFrail individuals are highly vulnerable to minor stressful events, presenting a higher risk for adverse health outcomes (e.g. falls, disability, hospitalization), which can lead to a decline in quality of life (QoL). In this context, an early screening of elderly frailty is of crucial importance.ObjectiveTo compare how the Frailty Phenotype (FP) and the Tilburg Frailty Indicator (TFI) predict QoL in a two-year follow-up.MethodsA longitudinal study was designed recruiting 110 community-dwelling elderly (≥ 65 years). The presence of frailty was assessed at baseline (FP ≥ 3 and TFI ≥ 6), whereas QoL was measured two years later with two different scales: the WHOQOL-OLD and the EUROHIS-QOL-8. Hierarchical regressions were conducted.ResultsThe mean age of the participants at baseline was 77.7 ± 6.9 years, and most were women (75.5%). According to FP, 33.6% of the participants were classified as frail, while the TFI detected frailty in 50% of the elderly. After adjusting for age and gender, the TFI significantly predicted QoL (WHOQOL-OLD: β = −18.9, t(106) = −6.97, P < 0.001; EUROHIS-QOL-8: β = −6.1, t(106) = −6.71, P < 0.001), whereas the effect of the FP on the outcome measures was non-significant.ConclusionsFrailty at baseline was associated with a lower QoL at follow-up. A multidimensional frailty operationalization (TFI) showed a stronger predictive validity than an exclusively physical one (FP). The option of which frailty measure to use in a clinical setting should take into account its ability to predict specific adverse outcomes, conducing to targeted and effective interventions.Disclosure of interestThe authors have not supplied their declaration of competing interest.
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Lalevée, Matthieu, Nacime S. Mansur, Hee Young Lee, Edward O. Rojas, Francois Lintz, Alexandre L. Godoy-Santos, John E. Femino, and Cesar de Cesar Netto. "Prevalence and Pattern of Lateral Impingements in the Progressive Collapsing Foot Deformity." Foot & Ankle Orthopaedics 7, no. 1 (January 2022): 2473011421S0030. http://dx.doi.org/10.1177/2473011421s00300.
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Category: Hindfoot; Midfoot/Forefoot Introduction/Purpose: Lateral impingements, subdivided into Sinus Tarsi (STI), Talo-Fibular (TFI), and Calcaneo-Fibular (CFI) impingements, appear to be associated with the Peritalar Subluxation (PTS) component of the Progressive Collapsing Foot Deformity (PCFD). This is not yet confirmed, as the chronological place of the different types of lateral impingements in PTS is unknown. It is also unclear whether STI are associated with PTS or Midfoot Abduction. Our primary objective was to assess the amount of PTS in STI, TFI and CFI. Our secondary objective was to determine the position of STI among the PTS and Midfoot Abduction deformities. We hypothesized that STI and TFI will be associated with a lower amount of PTS than CFI and that STI will be part involved in both PTS and Midfoot Abduction deformities. Methods: A retrospective study including 72 PCFD assessed with Weight Bearing Computed Tomography (WBCT) was realized. Patients under 15 or with a previous history of surgery were excluded. Lateral impingements were assessed on WBCT images and subdivided as STI, TFI and CFI. Both direct and indirect signs of impingement were considered positive. The amount of PTS was assessed by the percentage of uncoverage and the incongruence angle of the Middle Facet (MF). Midfoot-Abduction was assessed by Talonavicular coverage angle and global foot deformity by Foot and Ankle Offset (FAO). These data were collected by two independent observers and one performed a blinded second assessment. Interobserver and Intraobserver reliabilities were determined using unweighted Cohen's kappa values for lateral impingements and using intraclass correlation coefficients for the measurements. Impingement groups were compared using Student's T-tests for normal, and Mann-Whitney for non-normal variables. Results: Interobserver and Intraobserver reliabilities ranged from substantial to almost perfect for all assessments. STI was present in 84.7%, TFI in 65.2% and CFI in 19.4% of PCFD cases. PCFD with STI showed significant increases of MF uncoverage (p=0.0001), FAO (p=0.0008) and Talonavicular coverage angle (p=0.0197) compared to PCFD without STI. PCFD with TFI did not show significant difference on measurements compared to PCFD without TFI. PCFD with CFI had associated STI in 100% and TFI in 64.2% of cases. PCFD with CFI showed significant decreases of MF incongruence (p=0.0398) and significant higher FAO (p=0.0058) compared to PCFD without CFI. PCFD with both STI and CFI showed significant decreases of MF incongruence (p=0.032) and significant higher FAO (p=0.028) compared to PCFD with isolated STI. Conclusion: Our hypotheses have not been confirmed. STI was associated with both PTS and Midfoot Abduction deformities but neither TFI nor CFI were associated with PTS considering MF subluxation. Conversely, CFI was associated with a reduction of the MF incongruence angle despite being associated with a higher global deformity. STI may be associated with earlier PCFD with a concentration of the malignment forces in the subtalar joint whereas CFI may occur later and be associated with a failure of the deep layer of the deltoid ligament and a talar tilt. This could explain the relative reduction of the PTS in CFI.
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Jacquemin, Laure, Giriraj Singh Shekhawat, Paul Van de Heyning, Griet Mertens, Erik Fransen, Vincent Van Rompaey, Vedat Topsakal, Julie Moyaert, Jolien Beyers, and Annick Gilles. "Effects of Electrical Stimulation in Tinnitus Patients: Conventional Versus High-Definition tDCS." Neurorehabilitation and Neural Repair 32, no. 8 (July 18, 2018): 714–23. http://dx.doi.org/10.1177/1545968318787916.
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Background. Contradictory results have been reported for transcranial direct current stimulation (tDCS) as treatment for tinnitus. The recently developed high-definition tDCS (HD tDCS) uses smaller electrodes to limit the excitation to the desired brain areas. Objective. The current study consisted of a retrospective part and a prospective part, aiming to compare 2 tDCS electrode placements and to explore effects of HD tDCS by matched pairs analyses. Methods. Two groups of 39 patients received tDCS of the dorsolateral prefrontal cortex (DLPFC) or tDCS of the right supraorbital–left temporal area (RSO-LTA). Therapeutic effects were assessed with the tinnitus functional index (TFI), a visual analogue scale (VAS) for tinnitus loudness, and the hyperacusis questionnaire (HQ) filled out at 3 visits: pretherapy, posttherapy, and follow-up. With a new group of patients and in a similar way, the effects of HD tDCS of the right DLPFC were assessed, with the tinnitus questionnaire (TQ) and the hospital anxiety and depression scale (HADS) added. Results. TFI total scores improved significantly after both tDCS and HD tDCS (DLPFC: P < .01; RSO-LTA: P < .01; HD tDCS: P = .05). In 32% of the patients, we observed a clinically significant improvement in TFI. The 2 tDCS groups and the HD tDCS group showed no differences on the evolution of outcomes over time (TFI: P = .16; HQ: P = .85; VAS: P = .20). Conclusions. TDCS and HD tDCS resulted in a clinically significant improvement in TFI in 32% of the patients, with the 3 stimulation positions having similar results. Future research should focus on long-term effects of electrical stimulation.