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Dissertations / Theses on the topic 'TGF-beta'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Bünemann, Christoph Lars. "Molekulare Mechanismen der Inhibition TGF-[beta]-induzierter [TGF-beta-induzierter] Apoptose in Hepatomzellen." [S.l. : s.n.], 2000. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB8560503.

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2

Ouyang, Nengtai. "Effects of TGF-[beta]1 [TGF-beta-1] in ischemia, reperfusion injury and chronic allograft nephropathy." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972198628.

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3

Köhler, Heike Christine. "Die TGF-[beta] [TGF-beta] vermittelte Suppression der antigenspezifischen Immunantwort kann durch CD28 Kostimulation überwunden werden." München Verl. Dr. Hut, 2008. http://d-nb.info/992163080/04.

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4

Mecha, Ezekiel Onyonka [Verfasser]. "Characterization of the TGF-beta signalosome and of TGF-beta-dependent endometrial cell proliferation / Ezekiel Onyonka Mecha." Gießen : Universitätsbibliothek, 2014. http://d-nb.info/1068590459/34.

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5

Choi, Won Seon 1975. "Involvement of TGF-beta in skin photoaging." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/33842.

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Thesis (Ph. D.)--Harvard-MIT Division of Health Sciences and Technology, 2005.<br>Vita.<br>Includes bibliographical references.<br>The goal of this thesis study was to understand the role of TGF-[beta] in skin photoaging, especially in solar elastosis. Solar elastosis, the accumulation of elastotic material in the dermal extracelluar matrix, is a major hallmark of photoaging. However, the mechanisms by which UV radiation causes solar elastosis are poorly understood. TGF-[beta] is a multifunctional cytokine involved in the regulation of extracelluar matrix and is known to be up-regulated by UVR

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6

Dudu, Veronica. "TGF-beta signaling at the cellular junctions." [S.l. : s.n.], 2005. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB11878497.

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7

Peri, Francesca. "The role of EGF and TGF-[beta] [TGF-beta] signaling specifying the polarity of the Drosophila egg and embryo." [S.l. : s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=963638386.

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8

Kroner, Antje. "Klonierung und Charakterisierung von Rezeptorkinasen der EGF- und TGF[beta]-Familie [TGF-Beta-Familie] des kleinen Fuchsbandwurmes Echinococcus multilocularis." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=969749481.

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9

Möller, Antje. "Proliferation von Lungenfibroblasten in vitro unter dem Einfluss von ionisierender Strahlung bzw. von TGF-[beta]1 [TGF-beta-1]." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=974672165.

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10

Serwe, Annegret. "Hemmung der Angiogenese und Tumorprogression durch Blockierung der TGF-[beta]-Signaltransduktion [TGF-Beta-Signaltransduktion] durch neue Wirkstoffe isoliert aus Pilzen." Duisburg Köln WiKu, 2007. http://d-nb.info/987489674/04.

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11

Chen, Feng. "Phosphorylation and activation of transforming growth factor beta (TGF-[beta]) receptor kinases." Thesis, Massachusetts Institute of Technology, 1996. http://hdl.handle.net/1721.1/41406.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1996.<br>On t.p., "[beta]" appears as the lower case Greek letter. Vita.<br>Includes bibliographical references (leaves 166-207).<br>by Feng Chen.<br>Ph.D.

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12

Galliher, Amy Jo. "[Beta]₃ integrins enhance TGF-[beta]-mediated tumor progression in mammary epithelial cells /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2007.

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Thesis (Ph.D. in Pharmacology) -- University of Colorado Denver, 2007.<br>Typescript. Non-Latin script record Includes bibliographical references (leaves 112-128). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;

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13

Scharrer, Eva. "Consequences of HtrA1 deficiency on TGF-Beta signaling." Diss., Ludwig-Maximilians-Universität München, 2015. http://nbn-resolving.de/urn:nbn:de:bvb:19-185742.

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14

Patel, Vyomesh. "TGF-#beta# signal transduction mechanisms in epithelial carcinogenesis." Thesis, University of Bristol, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386229.

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15

Gu, Ye. "Homo & heterodimeric TGF-[beta] family growth factors." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610106.

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16

Sennett, Kristyn. "TGF-beta Receptors and Alcohol Sensitivity in Drosophila." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/2695.

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Clic proteins influence ethanol-related behavior in flies and other species and also mediate TGF-β signaling. These findings suggest that Clics and the TGF-β signaling pathway might work together to modulate behavioral responses to ethanol. I used the Drosophila model to address the hypothesis that TGF-β signaling is important for ethanol sensitivity. Ethanol sensitivity was blunted by multiple transposon insertions in the TGF-β receptor gene thickveins. Collectively, however, I found no consistent correlation between expression of thickveins and altered ethanol sensitivity in flies harboring

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17

Moosmann, Nicolas. "TGF-beta und Empfindlichkeit für NO-abhängige Apoptose." [S.l. : s.n.], 2002. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB10316263.

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18

Haase, Oliver. "Strahleninduzierte Aktivierung von TGF-[beta]1 [TGF-Beta-1] und Phosphorylierung von Smad2 im Prozess der terminalen Differenzierung von humanen Hautfibroblasten." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=973220317.

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19

Lam, Sze-man Joyce. "Expression of transforming growth factors (TGF-alpha and TGF-beta 1) on postmortem skin wounds /." View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38480566.

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20

林詩敏 and Sze-man Joyce Lam. "Expression of transforming growth factors (TGF-alpha and TGF-beta 1) on postmortem skin wounds." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B45011400.

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21

Isken, Frank. "Entwicklung und Anwendung einer HPLC-gestützten quantitative RNA-Analyse von drei Isoformen der TGF-[beta]-Familie [TGF-beta-Familie] in humanem Knochen." [S.l.] : [s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=961894806.

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22

Karagiannidis, Christian. "Activin A und TGF-[beta]1 [TGF-Beta-1] bei Asthma bronchiale: differentielle Expression und gemeinsame Funktionen sowie deren Regulation durch Glukokortikoide." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=974673056.

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23

Sevilla, Sánchez Pablo. "Functionalization of titanium surfaces with TGF-beta inhibitor peptides." Doctoral thesis, Universitat Politècnica de Catalunya, 2013. http://hdl.handle.net/10803/129568.

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Esta tesis queda enmarcada en el ámbito de los biomateriales metálicos, concretamente en superficies de titanio desarrolladas para la regeneración ósea. Las aplicaciones más habituales del titanio como biomaterial son los implantes dentales y las prótesis de cadera y rodilla. Estos componentes requieren, en servicio, buena estabilidad y fijación al hueso a largo plazo. El titanio es un material idóneo para el cumplimiento de estos requisitos gracias a su alta resistencia mecánica, tenacidad, resistencia a la corrosión y, sobre todo, por su alta capacidad de osteointegración. En general, el ti

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24

Chou, Yu-Ting. "Cited2, an autoregulated transcriptional modulator, in TGF-beta signaling." Connect to text online, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=case1147147222.

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25

Sarkar, Oliver. "Expression und Funktion der TGF-Beta-Isoformen in Hypophysentumorzellen." Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-67306.

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26

Rusholme, Sarah Ann Buchanan. "Strain-dependent variation in developmental TGF#beta# knockout phenotypes." Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361011.

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27

Jonker, Leon. "TGF-#beta# signalling : the roles of endoglin and TAKI." Thesis, University of Newcastle Upon Tyne, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270892.

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28

Lee, Jen Yee. "TGF-beta family ligands in autophagy and muscle wasting." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/24910.

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Chronic Obstructive Pulmonary Disease (COPD) is a collective term for emphysema, chronic bronchitis, and obstructive bronchiolitis, which is caused by chronic tobacco smoke exposure. COPD is a multi-system disease; skeletal muscle is one such system that is dysfunctional in a significant proportion of COPD patients. Muscle weakness and wasting is observed in COPD patients, with fibre type changes as well as fibre atrophy reported. Skeletal muscle as a target for pharmacotherapy in COPD as exercise training improves life expectancy and quality of life in patients. Loss of protein contributes to

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29

Petrel, Trevor Alan. "TGF-[beta] and estrogen signaling interactions in breast cancer /." The Ohio State University, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486572165278522.

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30

Shumaker, Stephanie D. "Improved methodology for refolding functional TGF-beta Superfamily ligands." Diss., [La Jolla] : University of California, San Diego, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p1465086.

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Thesis (M.S.)--University of California, San Diego, 2009.<br>Title from first page of PDF file (viewed June 22, 2009). Available via ProQuest Digital Dissertations. Includes bibliographical references (p. 35-37).

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31

Clarke, David Chisholm. "The quantitative analysis of TGF-beta/Smad signaling dynamics." Connect to online resource, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3315795.

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32

Fisichella, Vincenzo. "TGF-beta 1 pathway and age-related macular degenertion." Doctoral thesis, Università di Catania, 2017. http://hdl.handle.net/10761/3870.

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Purpose: To set up a retinal degenerative model in rat that mimics pathologic conditions such as age-related macular degeneration (AMD) using amyloid-beta (Abeta) oligomers, and assess the effect of TGF-beta 1. Furthermore a topical formulation of transforming growth factor 1 (TGF-beta 1) was developed; and TGF-beta 1 ocular pharmacokinetics profile was assessed. Methods: Sprague-Dawley male rats were used. Human Abeta 1-42 oligomers were intravitreally (ITV) injected in the presence or in the absence of recombinant human TGF-beta 1. The apoptotic markers Bax and Bcl-2 were assessed by wester

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33

Daig, Ute. "NO-vermittelte Effekte der Aminosäure L-Arginin auf die TGF-[beta]-Überexpression [TGF-Beta-Überexpression] im Modell der akuten Anti-Thy-1-Glomerulonephritis." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=976619776.

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34

Kadlec, Nicole [Verfasser]. "Optimierung der Transfektion pankreatischer Sternzellen mit TGF-beta-1-Antisense-Oligonukleotiden : ein Beitrag zum Nachweis autokriner Stimulationsmechanismen über TGF-beta-1 / Nicole Kadlec." Ulm : Universität Ulm. Medizinische Fakultät, 2005. http://d-nb.info/1015472060/34.

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35

Mead, Anna Louise. "Modulation of transforming growth factor beta (TGF beta) and conjunctival scarring after glaucoma filtration surgery." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1444824/.

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The conjunctival wound healing response remains the major barrier to achieving long term intraocular pressure control after glaucoma filtration surgery (GFS). Current anti-scarring agents improve the outcome of surgery but act by causing widespread cell death and can be associated with potentially blinding complications. In addition, some individuals still fail surgery. A more physiological and targeted approach to wound healing control and scarring prevention is required. Of all the growth factors, TGF beta has been shown to play a pivotal role in wound healing throughout the body, and has be

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36

Parker, Wendy Lynne. "TGF-[beta] receptors on human chondrocytes : hetero-oligomerization and function." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=19424.

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Human cartilage does not have the capacity for parent-like regeneration; instead, following injury, there is a programmed attempt at regeneration that ultimately results in fibrocartilage formation. This lack of intrinsic repair has been attributed to the avascular state of the tissue and chondrocyte dedifferentiation towards a cell incapable of type II collagen production and with altered responsiveness to the structural and regulatory mediators within its microenvironment. For several decades, debate has existed regarding the role Transforming Growth Factor-Beta (TGF-P) plays in modulating a

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37

Bolton, L. W. Y. T. "Recombinant TGF-beta type I and type II receptor domains." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596753.

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Transforming growth factor-β (TGF-β) is a multifunctional cytokine that signals by binding to two related transmembrane serine/threonine kinases called the type I and type II receptors. The <I>in vitro</I> binding properties of these receptors for the TGF-β1 and TGF-β3 isoforms were investigated by developing expression systems for recombinant extracellular domains (ECDs) of the type I and type II receptors, which also enabled the interaction of the two receptor domains to be examined. 1. A variety of vectors were constructed incorporating the fusion protein glutathione S transferase (GST) and

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38

Ruf, Doris Anne. "Die Entwicklung der Pankreasfibrose im TGF-beta-1-transgenen Tiermodell." [S.l. : s.n.], 2006. http://nbn-resolving.de/urn:nbn:de:bsz:289-vts-57128.

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39

Lee, Ellen. "Characterization of TGF-beta regulation during chronic infection with LCMV." Diss., [La Jolla] : University of California, San Diego, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p1467915.

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Thesis (Ph. D.)--University of California, San Diego, 2009.<br>Title from first page of PDF file (viewed September 15, 2009). Available via ProQuest Digital Dissertations. Includes bibliographical references (p. 44-51).

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40

Rafiei, Shahrzad. "Talin : a novel inducible antagonist of transforming growth factor-beta 1 (TGF-[beta]1) signal transduction." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=100203.

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The survival of breast cancer patients declines when tumors are invasive and have an increased possibility of metastasizing to distal sites. Transforming Growth Factor-beta (TGF-beta) suppresses breast cancer formation by preventing cell cycle progression in mammary epithelial cells. However, at late stage of mammary carcinogenesis, due to genetic and epigenetic alterations, TGF-beta loses its cytostatic actions, and contributes to tumor invasion by promoting cell proliferation, Actin cytoskeletal reorganization, as well as Epithelial to Mesenchymal Transition (EMT). Despite the key role of TG

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41

Henning, Kirsten [Verfasser]. "TGF-β-induzierte [TGF-beta-induzierte] Expression extrazellulärer Matrixproteine durch Herzmuskelzellen der adulten Ratte / eingereicht von Kirsten Henning". Giessen : VVB Laufersweiler, 2009. http://d-nb.info/1000412865/34.

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42

Rose, Aidan Michael. "Transforming growth factor-beta signalling in human cutaneous squamous cell carcinoma." Thesis, University of Dundee, 2015. https://discovery.dundee.ac.uk/en/studentTheses/51b1a1c1-ac43-4f60-aa77-9002af3f2186.

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There is an urgent need to define the key pathological driving events in human cutaneous squamous cell carcinoma (cSCC) in order to identify novel therapeutic targets. Already the second most common form of human non-melanoma skin cancer, the incidence of cSCC has continued to rise at epidemic proportions over the past two decades. Rarely, cSCC can be highly aggressive, causing significant soft-tissue defects in sun-exposed areas of skin and progressing to metastatic disease, which is usually associated with poor survival. The transforming growth factor-β (TGF-β) signalling pathway is known to

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43

Byrom, Daniel. "Synthesis of TGF-Beta inhibitors and compounds for spatiotemporal drug release." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/665149.

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During this doctoral thesis, we have synthesised hundreds of grams of the TGF-β inhibitor LY2157299 (Galunisertib). This product was used by the group of Eduard Batlle in their investigations into the roles that TGF-β plays in colorectal cancer. During the initial synthesis and subsequent scale up, we overcame hurdles including optimisation of the penultimate step of the reaction - giving reproducible results - as well as optimising conditions of the final solid form to provide a product which is suitable for formulation for the in vivo experiments. After discovering some of the drawback of LY

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44

Bizet, Albane. "Mechanisms of action of CD109, a novel TGF-beta co-receptor." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=104617.

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Transforming Growth Factor β (TGF-β) is a multifunctional cytokine that plays a critical role in cell growth, differentiation and extracellular matrix deposition. Dysregulation of its pathway has been implicated in tissue fibrosis and cancer. TGF-β signals via the type I (TGFBR1) and type II (TGFBR2) receptor complex, which phosphorylates their intracellular substrates, SMAD2 and SMAD3. The phosphorylated SMAD2/3 then forms a complex with SMAD4 and regulates target gene expression. Alternatively to the SMAD2/3 (canonical) pathway, TGF-β also elicits signalling via non-canonical pathways, such

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45

Marcoux, Anne 1978. "Characterization of a novel TGF-[beta] accessory receptor in human keratinocytes." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84058.

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Transforming growth factor-beta (TGF-beta) signaling is involved in a wide array of cellular responses in both physiological and pathological conditions. Dysregulation of TGF-beta action can lead to impaired tissue homeostasis and several developmental defects. Mechanisms regulating TGF-beta signal transduction include modulation of TGF-beta signaling receptor activity by accessory receptors. Our group has recently identified a GPI-anchored TGF-beta1 binding protein, r150, and has shown that it is implicated in the regulation of TGF-beta signaling in keratinocytes. Recent molecular clon

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46

Chojnowska-Monga, Monika. "Involvement of deubiquitinating enzymes in TGF[beta] receptor trafficking and signalling." Thesis, University of Liverpool, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.569178.

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The transforming growth factor-β (TGF β) superfamily of ligands controls a wide range of biological processes, including cellular differentiation, proliferation, motility, adhesion and apoptosis. It exerts its biological processes mainly through the TGF β receptor and downstream Smad proteins. Deregulation of TGF β signalling is associated with a variety of human diseases, including cancer. Ubiquitination is a reversible post-translational modification implicated In a variety of cellular processes, including proteasome-mediated protein degradation, DNA repair, regulation of transcription, endo

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47

Horbelt, Daniel Walter [Verfasser]. "Context specific signaling of TGF-beta receptor II / Daniel Walter Horbelt." Berlin : Freie Universität Berlin, 2012. http://d-nb.info/1026694299/34.

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48

Henning, Kirsten. "TGF-beta induzierte Expression extrazellulärer Matrixproteine durch Herzmuskelzellen der adulten Ratte." Giessen VVB Laufersweiler, 2009. http://geb.uni-giessen.de/geb/volltexte/2009/7319/index.html.

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49

Hachoumi, Mounia el. "Die Funktion von Bx42/Skip im TGF-beta/Dpp Signal Transduktionsweg." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2007. http://dx.doi.org/10.18452/15635.

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Die Notwendigkeit von Bx42 für Drosophila Entwicklung und seine Beteiligung an unterschiedlichen zellulären Prozessen wurde mit Hilfe von RNA Interference (RNAi) demonstriert. Das ubiquitäre Ausschalten oder die Reduktion der Bx42 Expression mittels RNAi führte dabei zu embryonaler Letalität. Weiterhin führte eine gewebespezifische Induktion von Bx42 in Abhängigkeit der verwendeten Treiberlinien bei unterschiedlichen Temperaturen zu mehreren verschiedenen adulten Phänotypen. Diese Phänotypen waren die Grundlage für die Annahme, dass Bx42 eine Rolle in der Regulation mehrerer verschiedener Zel

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50

Handra-Luca, Adriana Alina. "Rôle de la signalisation par la voie du TGF-beta et des protéines de réparation des mésappariements de l'ADN dans la prolifération cellulaire et dans la progression tumorale au cours de la cancérogenèse colorectale et de certains modèles de cancérogenèse pancréatique." Paris 6, 2004. http://www.theses.fr/2004PA066543.

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