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Journal articles on the topic 'TGFbeta pathway'

Author: Grafiati

Published: 1 April 2023

Last updated: 7 July 2024

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1

Verma, Amit. "Presentation name: TGFbeta pathway targeting." Leukemia Research 108 (September 2021): 106682.8. http://dx.doi.org/10.1016/j.leukres.2021.106682.8.

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2

Weiss, Alexander, and Liliana Attisano. "The TGFbeta Superfamily Signaling Pathway." Wiley Interdisciplinary Reviews: Developmental Biology 2, no. 1 (2012): 47–63. http://dx.doi.org/10.1002/wdev.86.

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3

Krishna, S., L. L. Maduzia, and R. W. Padgett. "Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans." Development 126, no. 2 (1999): 251–60. http://dx.doi.org/10.1242/dev.126.2.251.

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In C. elegans, the TGFbeta-like type II receptor daf-4 is required for two distinct signaling pathways. In association with the type I receptor daf-1, it functions in the dauer pathway. In addition, it is also required for body size determination and male tail patterning, roles which do not require daf-1. In an effort to determine how two different signals are transmitted through daf-4, we looked for other potential signaling partners for DAF-4. We have cloned and characterized a novel type I receptor and show that it is encoded by sma-6. Mutations in sma-6 generate the reduced body size (Sma)

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Tran, Dat Q., Ellen Regalado, and Dianna Milewicz. "Immune Perturbation In Patients With Tgfbeta Pathway Defects." Journal of Allergy and Clinical Immunology 133, no. 2 (2014): AB248. http://dx.doi.org/10.1016/j.jaci.2013.12.881.

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Wang, ZacK Z., Hao Bai, Melanie Arzigian, Yong-Xing Gao, and Wen-Shu Wu. "BMP4 and TGFbeta Differentially Regulate CD34+ Progenitor Development in Human Embryonic Stem Cells through SMAD-Dependent Pathway." Blood 112, no. 11 (2008): 889. http://dx.doi.org/10.1182/blood.v112.11.889.889.

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Abstract Pluripotent stem cells derived from patients, including embryonic stem (ES) cells and “induced pluripotent stem” (iPS) cells, are a promising area of regenerative medical research. A major roadblock toward human clinical therapies using ES cells or iPS cells is to define the factors that direct ES cell differentiation into lineage specific cells. We previously established a simple and efficient human embryonic stem cell (hESC) differentiation system to generate CD34+/CD31+ progenitor cells that gave rise to hematopoietic and endothelial cells (Nat Biotech.25:317, 2007). To advance pot

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French, Deborah, Francesca Belleudi, Maria Mauro, et al. "Expression of HPV16 E5 down-modulates the TGFbeta signaling pathway." Molecular Cancer 12, no. 1 (2013): 38. http://dx.doi.org/10.1186/1476-4598-12-38.

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Tran, Dat, Ellen Regalado, and Dianna Milewicz. "Immune perturbation in patients with TGFbeta pathway defects (LYM7P.729)." Journal of Immunology 192, no. 1_Supplement (2014): 193.17. http://dx.doi.org/10.4049/jimmunol.192.supp.193.17.

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Abstract Intro: Mutations in TGFbR1, TGFbR2 and SMAD3 are associated with familial thoracic aortic aneurysms and aortic dissections (TAAD). These patients offer an opportunity to study their immune development. Methods: PBMC from TAAD (n=9) and controls (CT, n=8) were analyzed by FACS. Th1 (IFNg) and Th17 (IL17A) were determined with intracellular cytokine staining. Foxp3+ Tregs were detected with anti-Foxp3. CD19+ were analyzed for naive (IgD+CD27-), unswitched (IgD+CD27+) and switched memory (IgD-CD27+). Plasmacytoid (CD303+pDC) and myeloid (CD1c+mDC) were defined within lineage-1 negative p

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Tervonen, Topi A., Denis Belitškin, Pauliina Munne, et al. "Abstract 834: Serine protease hepsin regulates tumor growth via TGFbeta-EGFR signaling axis." Cancer Research 82, no. 12_Supplement (2022): 834. http://dx.doi.org/10.1158/1538-7445.am2022-834.

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Abstract Hepsin (encoded by HPN gene) is a type II transmembrane serine protease, which is commonly overexpressed in carcinomas of prostate and breast. Hepsin protein is known to be stabilized by Ras-MAPK pathway signaling, and downstream, this protease regulates the degradation of extracellular matrix (ECM) components and activates growth factor pathways, including hepatocyte growth factor (HGF) and transforming growth factor beta (TGF beta) pathway. However, the impact of the hepsin-dependent signaling on cell proliferation and tumor growth is not well-understood. Therefore, we sought to cla

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Tang, S. J., P. A. Hoodless, Z. Lu, et al. "The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development." Development 125, no. 10 (1998): 1877–87. http://dx.doi.org/10.1242/dev.125.10.1877.

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TGFbeta-related factors are critical regulators of vertebrate mesoderm development. However, the signalling cascades required for their function during this developmental process are poorly defined. Tlx-2 is a homeobox gene expressed in the primitive streak of mouse embryos. Exogenous BMP-2 rapidly activates Tlx-2 expression in the epiblast of E6.5 embryos. A Tlx-2 promoter element responds to BMP-2 signals in P19 cells, and this response is mediated by BMP type I receptors and Smad1. These results suggest that Tlx-2 is a downstream target gene for BMP signalling in the primitive streak where

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Thatcher, J. D., C. Haun, and P. G. Okkema. "The DAF-3 Smad binds DNA and represses gene expression in the Caenorhabditis elegans pharynx." Development 126, no. 1 (1999): 97–107. http://dx.doi.org/10.1242/dev.126.1.97.

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Gene expression in the pharyngeal muscles of Caenorhabditis elegans is controlled in part by organ-specific signals, which in the myo-2 gene target a short DNA sequence termed the C subelement. To identify genes contributing to these signals, we performed a yeast one-hybrid screen for cDNAs encoding factors that bind the C subelement. One clone recovered was from daf-3, which encodes a Smad most closely related to vertebrate Smad4. We demonstrated that DAF-3 binds C subelement DNA directly and specifically using gel mobility shift and DNase1 protection assays. Mutation of any base in the seque

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11

Vargesson, Neil. "Vascularization of the developing chick limb bud: role of the TGFbeta signalling pathway." Journal of Anatomy 202, no. 1 (2003): 93–103. http://dx.doi.org/10.1046/j.1469-7580.2003.00133.x.

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12

Koromila, T., Z. Dailiana, S. Samara, C. Chassanidis, V. Aleporou - Marinou, and P. Kollia. "TGFbeta-BMP signaling pathway gene expression in osteoporotic postmenopausal women by DNA microarrays." Bone 48 (May 2011): S159. http://dx.doi.org/10.1016/j.bone.2011.03.350.

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13

Yang, Guo-Xiang, Zhe-Xiong Lian, Ya-Hui Chuang, et al. "CD8 T cells Play a Critical Role in Primary Biliary Cirrhosis of dnTGFbetaRII Mice (130.28)." Journal of Immunology 178, no. 1_Supplement (2007): S233. http://dx.doi.org/10.4049/jimmunol.178.supp.130.28.

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Abstract Human primary biliary cirrhosis (PBC) is characterized serologically by antimitochondrial antibodies (AMA) and histologically by an intense T cell portal infiltrate that destroys bile ducts. We have taken advantage of the PBC-like disease exhibited by dnTGFbetaRII mice and focused our attention on the liver T cell infiltrate. One major advantage to this animal model is the ability to perform cell transfer. Therefore to address the issue of T cell effector mechanisms, we isolated dnTGFbetaRII splenic CD4+ or CD8+ T cells and transferred these populations into Rag1 k/o mice. Importantly

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14

Postigo, A. A. "Opposing functions of ZEB proteins in the regulation of the TGFbeta/BMP signaling pathway." EMBO Journal 22, no. 10 (2003): 2443–52. http://dx.doi.org/10.1093/emboj/cdg225.

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15

Moubarak, Rana, Ana De Pablos-Aragoneses, Vanessa Ortiz-Barahona, et al. "Abstract B30: The histone demethylase PHF8 epigenetically regulates the TGFbeta pathway to promote melanoma metastasis." Cancer Research 80, no. 19_Supplement (2020): B30. http://dx.doi.org/10.1158/1538-7445.mel2019-b30.

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Abstract The specific contribution of epigenetic dysregulation to the metastatic process remains understudied. Through a meta-analysis of gene expression datasets followed by a functional mini-screen, we identified PHF8, a histone demethylase of the Jumonji C proteins family, as a novel prometastatic factor in melanoma. Loss- and gain-of-function approaches demonstrate that PHF8 promotes cell invasion without affecting proliferation in vitro, and increases dissemination but not tumor growth in vivo, thus strengthening its specific contribution to the acquisition of metastatic potential. PHF8 d

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Mintzer, K. A., M. A. Lee, G. Runke, J. Trout, M. Whitman, and M. C. Mullins. "Lost-a-fin encodes a type I BMP receptor, Alk8, acting maternally and zygotically in dorsoventral pattern formation." Development 128, no. 6 (2001): 859–69. http://dx.doi.org/10.1242/dev.128.6.859.

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TGFbeta signaling pathways of the bone morphogenetic protein (BMP) subclass are essential for dorsoventral pattern formation of both vertebrate and invertebrate embryos. Here we determine by chromosomal mapping, linkage analysis, cDNA sequencing and mRNA rescue that the dorsalized zebrafish mutant lost-a-fin (laf) is defective in the gene activin receptor-like kinase 8 (alk8), which encodes a novel type I TGFbeta receptor. The alk8 mRNA is expressed both maternally and zygotically. Embyros that lack zygotic, but retain maternal Laf/Alk8 activity, display a weak dorsalization restricted to the

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17

Yokouchi, Y., J. Sakiyama, T. Kameda, et al. "BMP-2/-4 mediate programmed cell death in chicken limb buds." Development 122, no. 12 (1996): 3725–34. http://dx.doi.org/10.1242/dev.122.12.3725.

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During limb development, the mesenchymal cells in restricted areas of limb bud, anterior necrotic zone, posterior necrotic zone, opaque zone and interdigital necrotic zones, are eliminated by programmed cell death. The transcripts of bone morphogenetic protein (Bmp)-2 and −4 were first detected in the areas where cell death was observed, then showed overlapping expression with the programmed cell death zones except the opaque zone. To investigate the function of BMP-2 and BMP-4 during limb pattern formation, the dominant negative form of BMP receptor was overexpressed in chick leg bud via a re

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Wu, Xiao-Ling, Wei-Zheng Zeng, Ming-De Jiang, Jian-Ping Qin, and Hui Xu. "Effect of Oxymatrine on the TGFbeta-Smad signaling pathway in rats with CCl4-induced hepatic fibrosis." World Journal of Gastroenterology 14, no. 13 (2008): 2100. http://dx.doi.org/10.3748/wjg.14.2100.

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Fazio, Grazia, Chiara Palmi, Greta Giordano Attianese, Andrea Biondi, Antonius Rolink, and Giovanni Cazzaniga. "PAX5/TEL Causes down Regulation of CD19 and TGFbeta Resistance in PreBI Cells." Blood 108, no. 11 (2006): 1416. http://dx.doi.org/10.1182/blood.v108.11.1416.1416.

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Abstract The PAX5/TEL chimeric gene was cloned from the translocation t(9;12)(q11;p13) in an ALL patient. Recent data indicate that the PAX5/TEL fusion defines the cytogenetic entity dic(9;12)(p13;p13), which accounts for about 1% of childhood ALL, almost exclusively B-progenitor ALL. PAX5/TEL is likely to be an aberrant transcription factor, resulting from joining the 5′ region of PAX5 (a transcription factor essential for B cell development) to the 3′ region of TEL/ETV6, containing the Ets-family DNA binding domain. We have cloned the FLAG-full length chimeric PAX5/TEL cDNA in the retroviral

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Zhao, JY, and B. Chen. "ID: 118: UBIQUITIN E3 LIGASE FIEL1 REGUALTES TGFBETA SIGNALING IN LUNG FIBROBLAST." Journal of Investigative Medicine 64, no. 4 (2016): 967.2–967. http://dx.doi.org/10.1136/jim-2016-000120.116.

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Tumor growth factor β (TGFb) signaling plays a key role in the pathogenesis of tissue fibrosis, specifically Idiopathic Pulmonary Fibrosis (IPF). IPF is the deadliest of interstitial lung diseases with a median survival of merely three years. Currently IPF affects more than 35,000 patients each year, but despite extensive research, there is still no effective treatment. Thus, the discovery of new models that regulate TGFb signaling and reveal “authentic” drug targets could serve as a springboard for the introduction of a new generation of anti-fibrotic agents to be used in the clinical arena.

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21

Lints, R., and S. W. Emmons. "Patterning of dopaminergic neurotransmitter identity among Caenorhabditis elegans ray sensory neurons by a TGFbeta family signaling pathway and a Hox gene." Development 126, no. 24 (1999): 5819–31. http://dx.doi.org/10.1242/dev.126.24.5819.

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We have investigated the mechanism that patterns dopamine expression among Caenorhabditis elegans male ray sensory neurons. Dopamine is expressed by the A-type sensory neurons in three out of the nine pairs of rays. We used expression of a tyrosine hydroxylase reporter transgene as well as direct assays for dopamine to study the genetic requirements for adoption of the dopaminergic cell fate. In loss-of-function mutants affecting a TGFbeta family signaling pathway, the DBL-1 pathway, dopaminergic identity is adopted irregularly by a wider subset of the rays. Ectopic expression of the pathway l

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Chen, Junfeng, Xiaojun Guo, Guangjun Zeng та Jianhua Liu. "Effect of miR-34a on Postmenopausal Osteoporosis in Rats Through TGFβ/Smad Signaling Pathway". Journal of Biomaterials and Tissue Engineering 10, № 4 (2020): 487–92. http://dx.doi.org/10.1166/jbt.2020.2281.

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30 healthy SD rats of three months were chosen and divided randomly into shamed group, model group, miR-34a mimic transfection group, each of 10 cases. Then to detect serum miR-34a level after three months, TGF-β , Smad4 proteins levels by western blot, serum Ca level, bone mineral density (BMD), bone metabolic markers total type I collagen amino-terminal elongation peptide (TPINP), unique sequence of beta-collagen (beta-CTX), Histopathological Observation and Morphometric Detection of Bone after executed. Results The levels of miR-34a, TGF-β, Smad4 in transfection group were significantly hig

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Malik, M., J. Britten-Webb, G. Levy, M. Gilden, and W. H. Catherino. "Tgfbeta mediated fibrosis in leiomyoma cells works through the smad dependent signaling and not through MAPK/ERK pathway." Fertility and Sterility 98, no. 3 (2012): S72. http://dx.doi.org/10.1016/j.fertnstert.2012.07.260.

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Baron, Margaret H., Stephen Willey, Kenneth Sahr, et al. "Induction and Patterning of Pre-Hemato-Vascular Mesoderm by the Mouse Mix Homeodomain Protein." Blood 104, no. 11 (2004): 565. http://dx.doi.org/10.1182/blood.v104.11.565.565.

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Abstract Members of the Xenopus and zebrafish Mix/Bix family of paired class homeodomain proteins play determining roles in both mesoderm and endoderm development and are induced by members of the TGFbeta/BMP family of signaling molecules. A single Mix gene has been identified in mouse, humans and chick. Prior to gastrulation, the mouse Mix (mMix) gene is expressed in the visceral endoderm and later in the primitive streak and nascent mesoderm, where it overlaps, in part, with T. Mix expression in ES-derived embryoid bodies is early and transient, overlapping partially with Flk1 activation aro

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Nagamatsu, Yasuko, and Yasumi Ohshima. "Mechanisms for the control of body size by a G-kinase and a downstream TGFbeta signal pathway in Caenorhabditis elegans." Genes to Cells 9, no. 1 (2004): 39–47. http://dx.doi.org/10.1111/j.1356-9597.2004.00700.x.

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Bakker, W., CKE Dingenouts, K. Lodder, et al. "P348Impaired macrophage polarization in endoglin haplo-insufficiency leading to defective tissue repair is recovered by counter balance the TGFbeta pathway." Cardiovascular Research 103, suppl 1 (2014): S63.4—S63. http://dx.doi.org/10.1093/cvr/cvu091.34.

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Wang, S. X., J. Wang, E. Ozhegov, et al. "Identification of unique gene expression signatures in colon cancer stroma using microarray technology." Journal of Clinical Oncology 29, no. 4_suppl (2011): 447. http://dx.doi.org/10.1200/jco.2011.29.4_suppl.447.

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447 Background: Microarrays are widely used to study gene expression patterns in cancer. In colorectal cancer, it has proven useful to predict recurrence. The majority of expression profiles are generated from the cancer itself. Given the increasing evidence of importance of the microenvironment for tumor invasion, progression and metastasis, we explored tumor stroma gene signature using microarrays. Methods: Four formalin-fixed paraffin embedded (FFPE) colon cancer specimen carrying a pathological stage of T3-4/N0-2 were retrieved. Tumor stroma and normal stroma were separated using microdiss

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Hess, Julia, Kristian Unger, Cornelius Maihoefer, et al. "Integration of p16/HPV DNA Status with a 24-miRNA-Defined Molecular Phenotype Improves Clinically Relevant Stratification of Head and Neck Cancer Patients." Cancers 14, no. 15 (2022): 3745. http://dx.doi.org/10.3390/cancers14153745.

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Human papillomavirus (HPV)-driven head and neck squamous cell carcinomas (HNSCC) generally have a more favourable prognosis. We hypothesized that HPV-associated HNSCC may be identified by an miRNA-signature according to their specific molecular pathogenesis, and be characterized by a unique transcriptome compared to HPV-negative HNSCC. We performed miRNA expression profiling of two p16/HPV DNA characterized HNSCC cohorts of patients treated by adjuvant radio(chemo)therapy (multicentre DKTK-ROG n = 128, single-centre LMU-KKG n = 101). A linear model predicting HPV status built in DKTK-ROG using

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Zhang, Boxi, Ali Elmabsout, Hazem Khalaf, et al. "The periodontal pathogen Porphyromonas gingivalis changes the gene expression in vascular smooth muscle cells involving the TGFbeta/Notch signalling pathway and increased cell proliferation." BMC Genomics 14, no. 1 (2013): 770. http://dx.doi.org/10.1186/1471-2164-14-770.

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Krause, Daniela S., Keertik Fulzele, Andre Catic, et al. "Parathyroid Hormone-Induced Modulation of the Bone Marrow Microenvironment Reduces Leukemic Stem Cells in Murine Chronic Myelogenous-Leukemia-Like Disease Via a TGFbeta-Dependent Pathway." Blood 118, no. 21 (2011): 1670. http://dx.doi.org/10.1182/blood.v118.21.1670.1670.

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Abstract Abstract 1670 It is known that osteoblastic cells regulate the normal hematopoietic stem cell (HSC) niche and control its size. Parathyroid hormone (PTH) is an important regulator of osteoblasts and osteoclasts maintaining calcium homeostasis and, additionally, increasing HSC number in transplant recipients and protecting HSCs from repeated exposure to cytotoxic chemotherapy. We, therefore, hypothesized, that PTH-treatment may allow normal HSCs to outcompete leukemic stem cells (LSCs) in a murine model of chronic myelogenous leukemia. Mice with osteoblastic cell-specific constitutive

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Ellenrieder, Volker, Sandra F. Hendler, Claudia Ruland, et al. "Evidence for a cross-talk between the TGFbeta-signalling cascade and the RAS/MEK/MAPK-pathway in mediating transdifferentiation and invasion of pancreatic cancer cells." Gastroenterology 118, no. 4 (2000): A531. http://dx.doi.org/10.1016/s0016-5085(00)84255-9.

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Chang, Seon Hee, Heon Park, and Chen Dong. "Act1 adaptor protein is an immediate and essential signaling component of interleukin-17 receptor (B52)." Journal of Immunology 178, no. 1_Supplement (2007): LB11. http://dx.doi.org/10.4049/jimmunol.178.supp.b52.

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Abstract Interleukin (IL)-17, the founding member of the IL-17 cytokine family, is the hallmark of a novel subset of CD4+ T cells that is regulated by TGFbeta, IL-6, and IL-23. IL-17 plays an important role in promoting tissue inflammation in host defense against infection and in autoimmune diseases. Although IL-17 has been reported to regulate the expression of proinflammatory cytokines, chemokines, and matrix metalloproteinases, the signaling mechanism of IL-17 receptor has not been understood. An earlier study found that IL-17 activates NF-kappaB and MAPK pathways and requires TRAF6 to indu

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Carniti, Cristiana, Silvia Gimondi, Davide Lucini, et al. "Noninvasive Prediction of Acute Graft-Verus-Host Disease Following Allogeneic Hematopoietic Stem Cell Transplantation by Circulating miRNA Profiling." Blood 118, no. 21 (2011): 311. http://dx.doi.org/10.1182/blood.v118.21.311.311.

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Abstract Abstract 311 Background: Acute graft-versus-host disease (aGVHD) results in significant morbidity and mortality and remains the main complication of alloHSCT. Noninvasive, diagnostic and prognostic tests for aGVHD are currently lacking but essential to predict GVHD and to improve the safety and accessibility of alloHSCT. We hypothesized that the prospective analysis of miRNA expression profile in the plasma of allografted patients could allow for the detection of specific miRNAs with predictive role for aGVHD. Methods: After informed consent, we collected plasma samples from 10 health

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Tabe, Yoko, Linhua Jin, Yasuhito Hatanaka, et al. "Integrative Genomic and Proteomic Analysis Of Low-Dose ionizing Irradiation Effects On Bone Marrow Stromal Microenvironment and On Survival Of Pre-Leukemic Cells." Blood 122, no. 21 (2013): 3775. http://dx.doi.org/10.1182/blood.v122.21.3775.3775.

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Abstract Ionizing radiation is known to induce remodeling of stromal microenvironment and enhance cancer progression. In this study, we investigated the molecular alterations of low-dose ionizing radiation (LDIR) induced non-targeted/bystander responses which affect a complex interplay of stromal cells and pre-leukemic cells in the bone marrow (BM) microenvironment. As a model of BM stromal cells and pre-leukemic cells, we utilized primary BM-derived stromal cells (MSCs) and the Epstein- Barr virus (EBV) infected and immortalized pre-leukemic B-lymphocyte cell line (EBV-B). LDIR (100 mGy, 4MV

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Daley, Jessica D., Elina Mukherjee, A. Carolina Tufino, Riyue Bao, and Kelly M. Bailey. "Abstract 2641: Transcriptional reprogramming of Ewing tumors: gains and losses noted when utilizing immunocompetent in vivo models." Cancer Research 84, no. 6_Supplement (2024): 2641. http://dx.doi.org/10.1158/1538-7445.am2024-2641.

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Abstract Objective: Ewing sarcoma is an aggressive cancer most frequently diagnosed in adolescents and young adults. Currently, there is a limited understanding of the immunobiology of Ewing sarcoma, including limited pre-clinical studies of immunotherapeutic interventions. This, in part, is due to the historical lack of an immuno-competent murine model. Here, we utilize an immunocompetent, humanized mouse model to investigate the Ewing tumor immune microenvironment. Specifically, we sought to determine the transcriptional differences that occur when comparing human Ewing tumors established in

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Shapira, I., R. Huffman, E. Neculiseanu, et al. "P2: SNP ANALYSIS IN BRCA POSITIVE AND BRCA NEGATIVE SUBJECTS WITH AND WITHOUT BREAST CANCER (BRCA) REVEAL CENTRAL ROLE OF ALK SNPS AND TGFBETA SUPERFAMILY IN MALIGNANT TRANSFORMATION." Journal of Investigative Medicine 64, no. 3 (2016): 817.3–818. http://dx.doi.org/10.1136/jim-2016-000080.42.

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Purpose of StudyOver 240,000 individuals are diagnosed with breast cancer each year in the USA. Outcomes depend on DNA deregulations in tumors. Carriers of deleterious BRCA1 and BRCA2 mutations are predisposed to 30 fold higher lifetime risks of breast and ovarian cancer.Aims:1. To check for differences in SNPs of genomic DNA obtained in BRCA+/− with and without BrCa.2. Analyze correlates of molecular mechanisms occurring in BRCA mutant patients.Methods UsedWe analyzed 94 subjects (41 BRCA positive) with or without BrCa to detect SNPs whose expression is significantly differentially expressed

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Nagel, Stefan, Letizia Venturini, Grzegorz K. Przybylski, et al. "NK-Like Homeodomain Proteins Regulate NOTCH3-Signaling in T-Cells." Blood 112, no. 11 (2008): 1194. http://dx.doi.org/10.1182/blood.v112.11.1194.1194.

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Abstract Three NK-like (NKL) homeobox genes, TLX1/HOX11, TLX3/HOX11L2 and NKX2- 5/CSX, have been implicated in T-cell acute lymphoblastic leukemia (T-ALL). Here we screened further NKL genes in 24 T-ALL cell lines by RT-PCR and identified common expression of MSX2, highlighting this homeobox gene as a potential physiological family member in T-cells. Subsequent quantification of MSX2 confirmed expression in primary hematopoietic cells demonstrating higher levels in CD34+ stem cells when compared to peripheral blood cells or mature CD3+ T-cells. Analysis of core thymic factors in T-ALL cell lin

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Labbe, E., A. Letamendia, and L. Attisano. "Cooperative signalling by TGFbeta and Wnt signalling pathways." Biochemical Society Transactions 28, no. 5 (2000): A272. http://dx.doi.org/10.1042/bst028a272c.

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Hope, Chelsea, Ellen Hebron, Jaehyup Kim, et al. "Molecular Pathways That Determine the Activation State of Macrophages within the Myeloma Niche." Blood 120, no. 21 (2012): 443. http://dx.doi.org/10.1182/blood.v120.21.443.443.

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Abstract Abstract 443 Benefit from cytotoxic therapy in myeloma may be limited by persistence of residual tumor cells nested within favorable niches. However, the contribution of macrophages to the regulation of myeloma niches is still incompletely understood. We have previously shown that macrophages provide growth and anti-apoptotic signals to myeloma cells when grown in co-culture. These results prompted us to investigate the regulation of primary monocytes/macrophages that reside within myeloma niches in the bone marrow. Unmanipulated CD14+ monocytic cells, freshly explanted from myeloma b

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Faure, S., M. A. Lee, T. Keller, P. ten Dijke, and M. Whitman. "Endogenous patterns of TGFbeta superfamily signaling during early Xenopus development." Development 127, no. 13 (2000): 2917–31. http://dx.doi.org/10.1242/dev.127.13.2917.

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Transforming growth factor beta (TGFbeta) superfamily signaling has been implicated in patterning of the early Xenopus embryo. Upon ligand stimulation, TGFbeta receptors phosphorylate Smad proteins at carboxy-terminal SS(V/M)S consensus motifs. Smads 1/5/8, activated by bone morphogenetic protein (BMP) signaling, induce ventral mesoderm whereas Smad2, activated by activin-like ligands, induces dorsal mesoderm. Although ectopic expression studies are consistent with roles for TGFbeta signals in early Xenopus embryogenesis, when and where BMP and activin-like signaling pathways are active endoge

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Price, Colles O., Ping Chen, Zejuan Li, et al. "MLL-Rearrangements Result in Upregulation of Mir-9 and Subsequent Inhibition of the Tumor Suppressor TGFBI." Blood 118, no. 21 (2011): 2453. http://dx.doi.org/10.1182/blood.v118.21.2453.2453.

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Abstract Abstract 2453 Acute Leukemia represents one of the most deadly cancers in the United States. Clinical treatments in leukemia have progressed significantly through the use of therapies targeted specifically to chromosomal translocations. The success of these therapies has provided a model for future treatment in various cancers. However, there are various subtypes of leukemia where five-year survival and relapse rates have poor clinical outcome, indicating that new therapies are needed. A particular leukemia subtype, namely mixed lineage leukemia (MLL)-rearranged leukemia that is a res

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Salvi, Amrita, Laura R. Hardy, Kimberly N. Heath, et al. "Abstract B030: PAX8 modulates the tumor microenvironment of high grade serous ovarian cancer through changes in the secretome." Cancer Research 83, no. 2_Supplement_2 (2023): B030. http://dx.doi.org/10.1158/1538-7445.metastasis22-b030.

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Abstract High grade serous ovarian cancer (HGSC), the most common and lethal form of ovarian cancer, is a highly heterogeneous disease. HGSC is rarely detected early, and likely arises from the fimbriated end of the fallopian tube epithelium (FTE), and in some cases, the ovarian surface epithelium (OSE). PAX8 is a commonly used biomarker for ovarian serous tumors and is expressed in ~90% of HGSC. Although the OSE does not express PAX8, murine models of HGSC derived from the OSE acquire PAX8, suggesting that it is not only a marker of Müllerian origin, but also an essential part of cancer progr

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Papadas, Athanasios, Gauri Deb, Adam Officer, et al. "936 Stromal remodeling regulates dendritic cell abundance in the tumor microenvironment." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (2021): A982. http://dx.doi.org/10.1136/jitc-2021-sitc2021.936.

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BackgroundStimulatory dendritic cells (SDC), enriched within the Batf3-DC lineage (also known as conventional type 1 DC, cDC1), engage in productive interactions with CD8+ effectors along tumor-stroma boundaries. This puzzling pattern of T-cell-DC localization has been interpreted as ”tumor-exclusion”, limiting anti-tumor immunity. To understand this paradox, we hypothesized that dynamic matrix remodeling at the invasive margin generates unique activation and cell-fate cues critical for Batf3-DC homeostasis.MethodsWe studied immunocompetent tumor models of lung carcinoma, breast carcinoma, mel

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Kelley, Todd W., and Olga Efimova. "The Antioxidant n-Acetylcysteine Blocks Direct Regulatory T Cell Mediated Suppression of CD4+ Effector T Cells In Vitro." Blood 116, no. 21 (2010): 2765. http://dx.doi.org/10.1182/blood.v116.21.2765.2765.

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Abstract Abstract 2765 Background: CD4+CD25+FOXP3+ regulatory T cells (Tregs) employ a range of suppressive strategies including factors that are cytotoxic to target CD4+CD25−FOXP3− effector T cells (Teff) such as perforin and granzyme B and those that suppress proliferation, differentiation and/or cytokine production including TGF-beta1, IL-10 and CTLA-4. The relative contribution of each of these mechanisms to Treg function is unclear but from the available data their importance appears context specific. Because T cells are very sensitive to the redox state of the microenvironment, and displ

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Bordonaro, Michael, Shruti Tewari, Wafa Atamna, and Darina L. Lazarova. "The Notch ligand Delta-like 1 integrates inputs from TGFbeta/Activin and Wnt pathways." Experimental Cell Research 317, no. 10 (2011): 1368–81. http://dx.doi.org/10.1016/j.yexcr.2011.03.019.

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Jia, Haixia, Suhua Hao, Meiting Cao, et al. "m6A-Related lncRNAs Are Potential Prognostic Biomarkers of Cervical Cancer and Affect Immune Infiltration." Disease Markers 2022 (April 11, 2022): 1–22. http://dx.doi.org/10.1155/2022/8700372.

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The correlation of m6A-related lncRNAs with the prognosis and immune microenvironment of cervical cancer is not yet clear. In this study, we identified 7 m6A-related prognostic lncRNAs by Pearson correlation and univariate Cox regression analyses based on TCGA-cervical cancer dataset. Then, patients were divided into two clusters by consensus clustering based on the 7 m6A-related prognostic lncRNA expression. Cluster 1 was characterized by survival and stage disadvantage, enrichment of immunosuppressive and carcinogenic activation pathways. Besides, cluster 1 had higher immunosuppressive facto

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Tremblay, K. D., P. A. Hoodless, E. K. Bikoff, and E. J. Robertson. "Formation of the definitive endoderm in mouse is a Smad2-dependent process." Development 127, no. 14 (2000): 3079–90. http://dx.doi.org/10.1242/dev.127.14.3079.

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TGFbeta growth factors specify cell fate and establish the body plan during early vertebrate development. Diverse cellular responses are elicited via interactions with specific cell surface receptor kinases that in turn activate Smad effector proteins. Smad2-dependent signals arising in the extraembryonic tissues of early mouse embryos serve to restrict the site of primitive streak formation and establish anteroposterior identity in the epiblast. Here we have generated chimeric embryos using lacZ-marked Smad2-deficient ES cells. Smad2 mutant cells extensively colonize ectodermal and mesodermal

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Maxeiner, Hagen, Yaser Abdallah, Christoph Rüdiger Wolfram Kuhlmann, Klaus-Dieter Schlüter, and Sibylle Wenzel. "Effects of cerivastatin on adrenergic pathways, hypertrophic growth and TGFbeta expression in adult ventricular cardiomyocytes." European Journal of Cell Biology 91, no. 5 (2012): 367–74. http://dx.doi.org/10.1016/j.ejcb.2011.12.006.

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Stoika, Rostyslav, Mariya Yakymovych, Serhiy Souchelnytskyi, and Ihor Yakymovych. "Potential role of transforming growth factor beta1 in drug resistance of tumor cells." Acta Biochimica Polonica 50, no. 2 (2003): 497–508. http://dx.doi.org/10.18388/abp.2003_3702.

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Acquired drug resistance of tumor cells is frequently observed in cancer patients undergoing chemotherapy. We studied murine leukemia L1210 cells sensitive and resistant to the cytotoxic action of cisplatin and showed that cisplatin-resistant leukemia cells were also refractory to TGF beta1-dependent growth inhibition and apoptosis. Addressing the question about the mechanisms responsible for the cross-resistance to cisplatin and TGF beta1, we found that cisplatin- and TGF beta1-resistant L1210 cells possessed a decreased expression of type I TGF beta1 receptor, while the expression of type II

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Wharton, Natalia, Alyson Parris, Amy Reynolds, et al. "Su1734 Canonical Wnt Signals Combined With Suppressed TGFbeta/BMP Pathways Promote Renewal of the Native Human Colonic Epithelium." Gastroenterology 144, no. 5 (2013): S—463. http://dx.doi.org/10.1016/s0016-5085(13)61712-6.

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