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Dissertations / Theses on the topic 'Th1 and Th17 cells'

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Published: 11 March 2023

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1

Prendergast, Catriona Taguma. "Exploring the pathogenic potential of myelin-reactive Th1 and Th17 cells in central nervous system autoimmune disease." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5285.

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The activation of naïve T cells results in their proliferation and differentiation into a particular T-helper (Th) phenotype, namely Th1, Th2 or Th17 cells. This thesis focuses on the role of pro-inflammatory Th1 and Th17 cells in the induction of autoimmune disease of the central nervous system (CNS), using murine experimental autoimmune encephalomyelitis (EAE) as the model. Classically, EAE has been considered to be a Th1-mediated disease. However, since the emergence of the Th17 cells, there has been a paradigm shift towards Th17 cells being the key pathogenic subset in autoimmune disease.
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2

Costa, Fernando Augusto Miranda da. "Resposta imune in vitro aos antígenos de Papilomavírus Humano (HPV) em homens na cidade de São Paulo, Brasil." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5133/tde-04022014-155625/.

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Introdução: O Papilomavírus Humano está muito bem associado com diversos tipos de cânceres humanos, como câncer anogenital e oral. Alguns estudos demonstram que o aparecimento de lesões e a progressão para o câncer estão relacionados ao tipo de resposta imune do hospedeiro. Deste modo, evidências indicam que a resposta imune do hospedeiro tem um papel muito importante para o curso da infecção pelo HPV. Objetivo: Avaliar a resposta imune específica in vitro ao Papilomavírus Humano (HPV) em homens com lesões causadas por HPV e sem lesão por HPV. Material e Métodos: Foram recrutados 31 pacientes
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3

Zhang, W., X. Tian, F. Mumtahana, et al. "The existence of Th22, pure Th17 and Th1 cells in CIN and Cervical Cancer along with their frequency variation in different stages of cervical cancer." BioMed Central Ltd, 2015. http://hdl.handle.net/10150/610273.

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BACKGROUND: Recently, it is found that T-helper (Th) 22 cells are involved in different types of autoimmune and tumor diseases. But, till now, no study has been carried out to understand the involvement of these cells in cervical cancer (CC). METHODS: Flow cytometry was used to determine the expression of interferon gamma (IFN-gamma), Interleukin-22 (IL-22), IL-17 in the peripheral blood of healthy controls (HC), CIN and cervical cancer patients. From peripheral blood mononuclear cells (PBMCs), mRNA expression levels of Aryl hydrocarbon receptor (AHR), RAR-related orphan receptor C (RORC), TNF
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4

Pereira, Leonardo Biscaro. "Avaliação do perfil de citocinas no tecido subcutâneo de camundongos na presença de cimento endodôntico." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/58/58135/tde-03102013-151254/.

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Avaliou-se a capacidade dos cimentos endodônticos: Sealapex®, Activ-GP® e AH-Plus® de alterarem o perfil das citocinas nas respostas Th1, Th2 e Th17, após a implantação destes em subcutâneo de camundongos. A quantificação das citocinas IL-2, IL-6, TNF-α, IFN-γ, IL-4, IL-10 e IL-17 foi realizada in vivo, no tecido reacional circundante aos implantes, os quais foram confeccionados a partir de sondas nasogástricas estéreis e apirogênicas de cloreto de polivinila preenchidas com os cimentos, tendo um grupo controle com sondas vazias. Utilizou-se camundongos isogênicos da linhagem C57BL
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5

Medina, Tiago da Silva. "Participação do eixo Th17/IL-27 no controle da infecção experimental com Trypanosoma cruzi." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/17/17147/tde-02052014-160055/.

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Produzida por macrófagos e células dendríticas, a IL-27 é uma citocina heterodimérica capaz de induzir células Tr1 produtoras de IL-10 e consequentemente regular linfócitos Th1, Th2 e Th17, dependendo da doença envolvida. Partindo-se do pressuposto de que a infecção causada por Trypanosoma cruzi normalmente induz miocardite refletida pela migração intensa de linfócitos Th1 para o tecido cardíaco, nós analisamos o papel regulador da IL-27 nesta condição inflamatória. Nós inicialmente verificamos que a IL-27 foi prontamente induzida in vitro em células infectadas com T. cruzi. Para gerar miocard
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6

Tigno-Aranjuez, Justine Daphne Tiglao. "Adjuvant Guided T cell Responses." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1244035297.

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7

Yao, Chengcan. "Prostaglandin E2-EP4 signaling promotes immune inflammation through TH1 cell differentiation and TH17 cell expansion." Kyoto University, 2011. http://hdl.handle.net/2433/151930.

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8

Agorogiannis, Eleftherios. "TH17 cells in transplantation biology." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540084.

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9

Hull, Dobrina Nikolaeva. "The dynamics of Th17 and Th1 cells during anti-TNF therapy in patients with inflammatory arthritis and relationship with treatment response." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/29116.

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Anti-TNF agents have revolutionised the treatment of rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA), however a significant proportion of patients respond inadequately. Studies in murine and human arthritis have paradoxically shown that anti-TNF treatment can increase circulating Th17 and Th1 cells but the relationship of these changes to treatment response remains unclear. The aim of the work in this thesis was to conduct a prospective, longitudinal investigation of patients with inflammatory arthritis during anti-TNF treatment and using clinical, ultrasou
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10

Zager, Adriano. "A ativação imune materna e os efeitos sobre a imunidade, neuroinflamação e desenvolvimento da encefalomielite autoimune experimental na prole de camundongos." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/10/10133/tde-21112013-113642/.

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Experiências vivenciadas durante o período pré-natal são determinantes para a saúde do feto. A ocorrência de infecções maternas e a consequente ativação do sistema imune da mãe ocasionam uma série de alterações estruturais e funcionais no cérebro da prole, podendo predispor o indivíduo a transtornos psiquiátricos na vida pós-natal, como esquizofrenia e autismo. No entanto, estudos que investigam as alterações imunes na prole ainda são escassos na literatura. Dessa forma, o objetivo do presente estudo foi avaliar, na prole, o impacto da ativação imune materna sobre a atividade imune periférica,
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11

Schumann, Julia. "Intra- und extrazelluläre Signale während der T-Zellaktivierung und -differenzierung." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2014. http://dx.doi.org/10.18452/17076.

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Im ersten Teil dieser Dissertation wurde der Einfluss des mitochondrialen Proteins TCAIM (T cell activation inhibitor, mitochondrial) auf die T-Zellaktivierung untersucht. Hierzu wurde eine transgene Mauslinie mit einem T-zellspezifischen knock-in (KI) von Tcaim in den Rosa26 Lokus generiert. Die Tcaim-Überexpression beeinflusste die Fission und Umverteilung von Mitochondrien und reduzierte die T-Zellrezeptor (TZR)-induzierte Bildung mitochondrialer, radikaler Sauerstoffspezies. In vitro stimulierte CD4+ Tcaim KI T-Zellen zeigten eine geringere Aktivierung, Proliferation und IL-2 Sekretion als
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12

Zhao, Xiangli [Verfasser]. "Investigation on the role of CD26 in Th1 and Th17 cell differentiation and allogeneic graft rejection / Xiangli Zhao." Berlin : Freie Universität Berlin, 2018. http://d-nb.info/1158597665/34.

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13

Ferreira, Maria Carolina 1983. "Avaliação da capacidade de indução de diferenciação de células TH17 por células dendríticas estimuladas com células leveduriformes de Paracoccidioides brasiliensis e mecanismos de sinalização intracelular envolvidos." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311837.

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Orientadores: Ronei Luciano Mamoni, Maria Heloisa de Souza Lima Blotta<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-23T00:10:57Z (GMT). No. of bitstreams: 1 Ferreira_MariaCarolina_D.pdf: 3693187 bytes, checksum: 65dcd416d067ae66b391e67841a7b240 (MD5) Previous issue date: 2013<br>Resumo: A paracoccidioidomicose (PCM), causada pelo fungo dimórfico Paracoccidioides brasiliensis (Pb), é a micose sistêmica de maior incidência no Brasil. Estudos anteriores demonstraram que a resistência ou suscetibilidade a essa infec
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14

Nistala, K. "The role of Th17 cells in juvenile idiopathic arthritis." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1318100/.

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Autoimmune arthritis in childhood, know as juvenile idiopathic arthritis (JIA), has a heterogeneity, ranging from monoarthritis to recalcitrant polyarthritis, making it a model disease in which to study immuno-regulation. Regulatory T cells, key players in peripheral immune homeostasis are enriched in the joints of JIA patients, particularly those with mild arthritis. To test the factors that lead to this enrichment, Treg trafficking was examined in the context of JIA. Synovial Treg showed enhanced chemotaxis to the inflammatory chemokine CCL5, widely detectable within the joint, when compared
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15

Abdulaal, Wesam. "The role of Interleukin-1 signaling in the immune defense and in the development of the T helper cell lineage." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-interleukin-1-signaling-in-the-immune-defense-and-in-the-development-of-the-t-helper-cell-lineage(1432f7f4-7c04-4bc5-9fda-4441b5c14e66).html.

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IL-1 is a pro-inflammatory cytokine which play an important role in the activation and regulation of host defence and immune responses to inflammation or injury. IL-1 is able to bind and activate IL1-RI and IL1-RII, which are found on many cells types. The role of the IL-1 signalling in the deployment of Th cell subsets, especially Th17 cells is well known. However, the specific cells which are responsible for the expression of IL-1 signalling in the immune defense and in the development of the Th cell lineage in response to infection, is still largely unclear. Therefore in this thesis, IL1-RI
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16

Ourives, Samantha Soares. "Análise dos parâmetros parasitológicos e hematológicos e das subpopulações de células Th1, Th2, Th17, Treg e T citotóxica em pacientes com malária vivax." Universidade Federal de Mato Grosso, 2014. http://ri.ufmt.br/handle/1/496.

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Submitted by Simone Souza (simonecgsouza@hotmail.com) on 2017-09-22T15:04:46Z No. of bitstreams: 1 DISS_2014_Samantha Soares Ourives.pdf: 1603897 bytes, checksum: 16aacb8659dc1e9902e5038014c2c0ac (MD5)<br>Approved for entry into archive by Jordan (jordanbiblio@gmail.com) on 2017-09-26T14:26:40Z (GMT) No. of bitstreams: 1 DISS_2014_Samantha Soares Ourives.pdf: 1603897 bytes, checksum: 16aacb8659dc1e9902e5038014c2c0ac (MD5)<br>Made available in DSpace on 2017-09-26T14:26:40Z (GMT). No. of bitstreams: 1 DISS_2014_Samantha Soares Ourives.pdf: 1603897 bytes, checksum: 16aacb8659dc1e9902e5038014c2c
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Cheng, Wan-Chien. "The role of IL-17 and Th17 cells in the pathogenesis of periodontitis." Thesis, King's College London (University of London), 2015. https://kclpure.kcl.ac.uk/portal/en/theses/the-role-of-il17-and-th17-cells-in-the-pathogenesis-of-periodontitis(624cbe33-5647-4f82-9011-d1b1bb2104a5).html.

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The Th17/IL-17 pathway is increasingly implicated in the pathogenesis of periodontitis. However the mechanisms that drive this pathway in humans and the relationship of this pathway to disease severity are not fully understood. The first aim of this thesis was to investigate whether the periodontal pathogens Porphyromonas gingivalis (Pg) and Aggregatibacter actinomycetemcomitans (Aa) promote a Th17/IL-17 response in vitro, and to investigate the underlying mechanisms. The second aim was to determine the frequencies of IL-17+ CD4+ T cells in gingival tissue and peripheral blood from patients wi
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18

Silva, Felipe von Glehn 1978. "Esclerose múltipla = produção de citocinas pelos linfócitos Th17 e Th1 de pacientes tratados ou não com interferon beta e quantificação das células dentríficas plasmocitóides no líquido cefalorraquiano." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310333.

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Orientador: Leonilda Maria Barbosa dos Santos, Benito Pereira Damasceno<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-16T11:38:47Z (GMT). No. of bitstreams: 1 Silva_FelipevonGlehn_M.pdf: 1493222 bytes, checksum: 1c072cf5c2ad9f82ecb1b1e27c688bfc (MD5) Previous issue date: 2010<br>Resumo: A Esclerose Múltipla (EM) é uma doença primária do sistema nervoso central. Geralmente, expressa-se numa fase clínica de surto e remissão, mediada por lesões focais inflamatórias agudas na substância branca cerebral e medula
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19

Guo, Yawei, and 郭雅伟. "Adiponectin limits autoimmune encephalomyelitis by suppressing the differentiation of CD4+ cells into Th17 cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45207690.

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20

Podgaec, Sérgio. "Padrões de resposta imune em pacientes com endometriose." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-31102006-105026/.

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Objetivo: O objetivo deste estudo foi analisar a relação e a predominância dos padrões de resposta imune Th1 e Th2 em pacientes com endometriose. Pacientes e Métodos: Entre Fevereiro de 2004 e Abril de 2005 foram avaliadas 98 pacientes divididas em dois grupos de acordo com a presença (Grupo A) ou ausência de endometriose (Grupo B), confirmada histologicamente. Foram coletados sangue periférico e fluido peritoneal de todas as pacientes para a dosagem de interleucinas (IL) 2, 4 e 10, fator de necrose tumoral-alfa (TNF-alfa) e interferon-gama (IFN-gama) por citometria de fluxo. Além da presença
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21

Sato, Wakiro. "Human Th17 Cells Are Identified as Bearing CCR2+CCR5- Phenotype." Kyoto University, 2008. http://hdl.handle.net/2433/124335.

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22

Nguyen, Kim Phung Le. "Cholera Toxin Induces cAMP-dependent Th17 Differentiation by Dendritic Cells." Diss., [La Jolla] : University of California, San Diego, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p1465083.

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Thesis (M.S.)--University of California, San Diego, 2009.<br>Title from first page of PDF file (viewed June 19, 2009). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 47-55).
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23

Patakas, Agapitos. "The role of TH17 cells in a model of rheumatoid arthritis." Thesis, University of Glasgow, 2011. http://theses.gla.ac.uk/2867/.

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Introduction: While many studies on rheumatoid arthritis have focused on the active phase of the disease, the events that lead to the development of autoimmunity remain poorly defined. We have developed a model of breach of self tolerance, where a Th1 response to irrelevant antigen (OVA) results in arthropathy associated with spontaneous induction of autoreactive T and B cell responses, which allows the investigation of the immnologival events that lead to the development of autoreactivity. Employing this model the role of Th17 cells, a a subset of IL-17 producing CD4+ T important in autoimmun
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24

Stilla, Alana. "IL-7 Responses In Th17 Cells Are Dysregulated During HIV Infection." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/34068.

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In the gut-associated lymphoid tissues, Th17 cells mediate mucosal homeostasis and inflammation. During HIV infection, Th17 cells become depleted and functionally impaired, which is implicated in the pathogenesis of chronic inflammation in patients treated with highly active antiretroviral therapy. IL-7 is a cytokine that mediates homeostatic responses in T lymphocytes, such as proliferation and survival, which are dysregulated during HIV infection. Whether similar dysregulation occurs in Th17 cells has yet to be reported. IL-7 receptor α (CD127) expression and IL-7 responses were therefor
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25

Bending, David Alexander. "The behaviour of T helper 17 (Th17) cells in health and disease." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609853.

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26

Prado, Douglas da Silva. "Participação do Nlrp12 na diferenciação de linfócitos Th17 e no desenvolvimento da artrite experimental." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/17/17133/tde-20072016-162029/.

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A Artrite reumatoide é uma doença autoimune que acomete cerca de 1% da população mundial adulta, sendo caracterizada pela participação de linfócitos Th17 no seu desenvolvimento. Na busca por novos alvos terapêuticos e pela compreensão da fisiopatologia, se destacam os inflamassomas que são plataformas proteicas, caracterizados pela produção de citocinas pró-inflamatórias por células do sistema imune inato. De forma interessante, foi demonstrado que linfócitos T CD4 também expressam alguns sensores dessas plataformas, como o Nlrp12. Adicionalmente, este sensor é responsável pela modulação negat
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27

Pirronello, Fausto [Verfasser], and Alla [Akademischer Betreuer] Skapenko. "Altered T cell plasticity favors Th17 cells in rheumatoid arthritis / Fausto Pirronello ; Betreuer: Alla Skapenko." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/1202011888/34.

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Lee, Jinju. "IL-23 generates pathogenic Th17 cells by triggering T cell-intrinsic prostaglandin E2-EP2/4 signaling." Kyoto University, 2018. http://hdl.handle.net/2433/235123.

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Ganakammal, Satishkumar Ranganathan. "CIS REGULATORY MODULE DISCOVERY IN TH1 CELL DEVELOPMENT." Thesis, Proceeding ISB '10 Proceedings of the International Symposium on Biocomputing ACM New York, NY, USA ©2010 table of contents ISBN: 978-1-60558-722-6 doi>10.1145/1722024.1722039, 2010. http://hdl.handle.net/1805/2678.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Immune response enables the body to resist foreign invasions. The Inflammatory response is an important aspect in the immune response which is articulated by elements such as cytokines, APC, T-cell and B-cell, effector cell or natural killer. Of these elements, T-cells especially T-helper cells; a sub class of T-cells plays a pivotal role in stimulating the immune response by participating in various biological reactions such as, the transcription regulatory network. Transcriptional regulatory mechanisms are mediated by a set of tran
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30

Gabsi, Amira. "CD146/CD146s acteurs et cibles de la sclérodermie systémique." Thesis, Aix-Marseille, 2019. http://www.theses.fr/2019AIXM0645.

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La sclérodermie systémique (ScS) est une maladie auto-immune systémique caractérisée par des lésions vasculaires, une fibrose excessive et une dérégulation immunitaire. CD146 est une molécule d'adhésion essentiellement exprimée dans le système vasculaire, mais également sur les lymphocytes TH17. Compte tenu du rôle récemment décrit du CD146 dans la ScS, nous avons émis l’hypothèse d’une implication de cellules TH17 CD146 positives dans cette pathologie. Nous avons montré que les taux de CD146 (CD146s) et d’IL17A étaient plus importants chez les patients atteints de ScS par rapport aux témoins
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Morelli, Fernando Christiano Gabriel [UNESP]. "Quantificação de citocinas no conteúdo abomasal de bovinos de corte na presença ou ausência de ulceração gástrica." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/134249.

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Morelli, Fernando Christiano Gabriel. "Quantificação de citocinas no conteúdo abomasal de bovinos de corte na presença ou ausência de ulceração gástrica /." Araçatuba, 2016. http://hdl.handle.net/11449/134249.

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Orientador: Juliana Regina Peiró<br>Banca: Lina Maria Wehrle Gomide<br>Banca:Fernanda Bovino<br>Banca: José Paes de Oliveira Filho<br>Banca:Glenda Nicioli da Silva<br>Resumo: Erosões e úlceras são achados comuns no abomaso e causam preocupação econômica nos mais variados sistemas de produção de gado. Muitos fatores podem predispor ao aparecimento de úlceras e acúmulo de gases no abomaso, incluindo alimentos grosseiros, estresse ambiental, deficiências de vitaminas e minerais e infecções bacterianas. Essas úlceras podem ser subclínicas, sendo descobertas nas necropsias ou após o abate do animal
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Fenton, Thomas. "Integrin αvβ8 on human dendritic cells : a role in intestinal immune homeostasis". Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/integrin-alphav8-on-human-dendritic-cells-a-role-in-intestinal-immune-homeostasis(3820bc76-2c42-4db6-a344-b66e5b77769d).html.

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Intestinal inflammatory disorders such as Crohn’s disease contribute significantly to human mortality and morbidity. Although the cells and molecules involved in suppression of intestinal inflammation have been extensively documented in mouse models, a full understanding of how these work together in the healthy and diseased gut remains elusive. It is known, however, that tight regulation over TH17 cells and regulatory T cells (Treg) is required to maintain immune homeostasis in the intestine. Activation of the cytokine transforming growth factor-β (TGFβ), which is secreted by immune cells as
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Klees, Johanna [Verfasser]. "The Influence of Symbiont Bacteroides vulgatus on Th17 Differentiation via Dendritic Cells / Johanna Klees." Tübingen : Universitätsbibliothek Tübingen, 2021. http://d-nb.info/1240673272/34.

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35

Rehorova, Hradilkova Kristyna. "Role of Twist1 in metabolism of repeatedly stimulated Th1 cells." Doctoral thesis, Humboldt-Universität zu Berlin, 2019. http://dx.doi.org/10.18452/20584.

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Es stellt sich die Frage, wie diese Zellen im entzündeten Gewebe überleben können und wie sie ihren Stoffwechsel an die dortigen Bedingungen anpassen. Diese Arbeit beschreibt am Beispiel der Juvenilen Idiopathischen Arthritis (JIA) die Analyse des Stoffwechsels von CD4+ T Lymphozyten, die chronische Entzündungen antreiben undim entzündeten Gewebe lange Zeit persistieren. Pathogene CD4+ CD45RO+ PD1+ CXCR5-T Zellen wurden hierfür aus Synovialflüssigkeit von Patienten mit JIA isoliert und gezeigt, dass auch bei diesen Zellen der Stoffwechsel auf Fettsäureoxidation beruht. Wurde die Fettsäureoxida
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Ayala-Fontanez, Nilmarie. "Paradoxical onset of psoriasis after IL-6 receptor blockade." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1436396399.

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37

Esfandiari, Ehsanollah. "Role of Th1 and Th2 cytokines in the pathogenesis of systemic autoimmune diseases." Thesis, University of Glasgow, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366255.

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Hayes, Mark. "The role of innate and adaptive IL-17 producing cells in chemical allergy." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-innate-and-adaptive-il17-producing-cells-in-chemical-allergy(88fe6cd2-d6ca-4743-8889-cca8ab059815).html.

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The Interleukin (IL)-17 cytokine family, expressed by T helper (Th)17 cells and γδ T cells, plays pivotal roles in adaptive immune responses. They have been implicated in autoimmune and allergic diseases as well having roles in bacterial and fungal clearance. Importantly, IL-17 producing γδ T cells have been shown to be critical for the development of adaptive Th17 responses in the murine model of multiple sclerosis, experimental autoimmune encephalomyelitis. Interestingly, natural ligands of the aryl hydrocarbon receptor (AhR) are known to influence the development of Th17 cells. It has been
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Oo, Ye Htun. "Recruitment and positioning of regulatory T cells and Th17/Tc17 in inflamed human liver." Thesis, University of Birmingham, 2010. http://etheses.bham.ac.uk//id/eprint/1128/.

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The liver is a unique tolerogenic organ with dual blood supply. Both regulatory lymphocytes and effector lymphocytes are present in the normal and inflamed liver along with innate immune cells. The balance between these two subsets of lymphocyte is crucial in maintaining immune homeostasis by adjusting either hepatic tolerance or mounting immunity against invading pathogens. Thus, it is important to understand the intrahepatic regulatory T cells phenotype and role played by distinct chemokine receptors expressed on regulatory T cells as they are major player in controlling hepatic tolerance. A
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Wanke, Florian [Verfasser]. "The role of EBI2 for encephalitogenic TH17 cells in EAE and in MS / Florian Wanke." Mainz : Universitätsbibliothek Mainz, 2017. http://d-nb.info/1148689206/34.

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Hardaway, John C. Zaghouani Habib. "Examination of neonatal immunity in IL-13 receptor alpha 1 deficient mice." Diss., Columbia, Mo. : University of Missouri-Columbia, 2009. http://hdl.handle.net/10355/6977.

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The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from PDF of title page (University of Missouri--Columbia, viewed on January 5, 2010). Vita. Thesis advisor: Habib Zaghouani. Includes bibliographical references.
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Cantor, Joseph M. "Effector function of pathogenic CD4 TH1 T cells in autoimmune diabetes /." Connect to full text via ProQuest. IP filtered, 2005.

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Thesis (Ph.D. in Immunology) -- University of Colorado, 2005.<br>Typescript. Includes bibliographical references (leaves 180-202). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;
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Mancini, Francesca. "A PROMISING NOVEL FORMULATION OF STAPHYLOCOCCUS AUREUS VACCINE PROTECTS MICE VIA ANTIBODIES AND CD4+ EFFECTOR T CELLS." Doctoral thesis, Università degli studi di Padova, 2014. http://hdl.handle.net/11577/3423478.

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Life-threatening Staphylococcus aureus infections and the emergence of antibiotic-resistant strains make vaccination a major medical need. Novartis Vaccines developed a vaccine candidate (Combo) that consists of HlaH35L, a non-toxic mutant of the α-toxin, EsxAB, a fusion of the secreted factors EsxA and EsxB, and of two surface proteins, FhuD2 and Sur2. Combo±alum has shown efficacy in pre-clinical mouse models and has recently been tested in a human phase I clinical trial. To improve this vaccine further, Combo antigens were formulated with alum/SMIP-7.10 (alum-S-7), a novel adjuvant formul
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Andrade, Mariana Macedo Costa de. "O efeito da tolerância à endotoxina nos linfócitos T regulatórios e Th 17." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5164/tde-20092016-155050/.

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O controle de respostas imunes patológicas (autoimunidade, alergia, rejeição de transplantes) tem sido um dos principais objetivos dos imunologistas. Apesar dos avanços recentes, a maioria dos tratamentos atuais ainda procura diminuir a imunidade e inflamação em vez de restabelecer o estado saudável da tolerância imunológica. Sepse é uma doença desencadeada pela presença de bactérias e/ou produtos bacterianos como lipopolissacarídeos (LPS), componente principal da membrana externa de bactérias gram-negativas, ativando a resposta imune do hospedeiro. A caracterização do perfil de linfócitos na
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Monteiro, Barbara Vanessa de Brito. "An?lise da resposta Th17 em l?quen plano oral." Universidade Federal do Rio Grande do Norte, 2012. http://repositorio.ufrn.br:8080/jspui/handle/123456789/17122.

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Made available in DSpace on 2014-12-17T15:32:21Z (GMT). No. of bitstreams: 1 BarbaraVBM_DISSERT.pdf: 1563576 bytes, checksum: c536e73cdfce0251b3446e74e0f9cc69 (MD5) Previous issue date: 2012-02-24<br>Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico<br>Th17 cells have been strongly associated with the pathogenesis of several autoimmune and inflammatory diseases. IL-17 and IL-23 are important cytokines associated with this lineage. The aim of this study was to analyze, through immunohistochemical methods, the immunoexpression of IL-17 and IL-23 in the inflammatory infiltrate
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Santos, Juliana do Outeiro. "Impacto da exposição fetal ao HIV-1 na função das células T e das células dendríticas de neonatos não infectados." Universidade do Estado do Rio de Janeiro, 2010. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=3795.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>A síndrome da imunodeficiência adquirida (AIDS), causada pelo vírus da imunodeficiência humana (HIV), é uma das epidemias mais impactantes do milênio e, desde o início, o número de mulheres jovens infectadas vem aumentando vertiginosamente, principalmente nos países em desenvolvimento onde muitas destas engravidam precocemente. Apesar da grande maioria dos casos de AIDS pediátrico no mundo resultar da transmissão vertical, aproximadamente dois terços dos neonatos expostos ao HIV durante a vida fetal não são contaminados. Neste se
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Santos, Márcio Bezerra. "Resposta imune a antígenos de Mycobacterium leprae e apresentação clínica da hanseníase como perspectiva para o desenvolvimento de ferramentas para prognóstico e imunoprofilaxia." Universidade Federal de Sergipe, 2017. http://ri.ufs.br:8080/xmlui/handle/123456789/3640.

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Leprosy is a chronic infectious disease caused by Mycobacterium leprae. It is estimated that less than 1% of the individuals infected with M. leprae develop the disease. Several authors suggest that the genetic pattern and variations in the mechanisms of the patient's immune response influence the susceptibility or resistance to disease. The most recent studies have established the role of Th1, Th2 and Treg cell responses in immunopathogenesis of leprosy. However, several mechanisms of the immune response that act in clinical evolution still lack clarification, such as the role of Th17 cells,
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McGovern, J. "The influence of biologic therapy on the capacity of regulatory T cells to restrain Th17 responses." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1363638/.

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The importance of IL-17 is underscored both by its resistance to control by regulatory T cells (Treg) and the propensity of Treg to produce this highly inflammatory cytokine. I addressed whether Th17 cells are inhibited by Treg from anti-TNF treated rheumatoid arthritis (RA) and psoriatic arthritis patients (PsA) and defined the underlying mechanisms. Th17 responses were inhibited by Treg isolated from RA patients responding to the anti-TNF antibody adalimumab, but not by Treg from healthy individuals or patients with active RA. Furthermore, in patients with RA, response to adalimumab therapy
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Ghannam, Soufiane. "Les lymphocytes Th17 humains : modulation de leur fonction effectrice par les cellules souches mésenchymateuses et caractérisation de leurs propriétés migratoires." Thesis, Montpellier 1, 2010. http://www.theses.fr/2010MON1T023.

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Les lymphocytes Th17 forment une population de cellules T CD4+ pro-inflammatoires, impliqués non seulement dans l'élimination d'agents pathogènes, mais ayant aussi un rôle délétère dans l'induction de maladies inflammatoires chroniques. Ils expriment spécifiquement le récepteur de chimiokines CCR6, qui a pour ligand le CCL20 mais aussi les β-defensine-1, 2 et 3, peptides ayant une activité antimicrobienne. Les cellules souches mésenchymateuses (CSMs) représentent une population cellulaire hétérogène exerçant diverses propriétés immunomodulatrices.Les résultats obtenus dans c
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Debock, Isabelle. "Study of the development of Th17-type immune response in early life." Doctoral thesis, Universite Libre de Bruxelles, 2012. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209700.

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Par rapport à l’adulte, le nouveau-né présente une susceptibilité accrue aux agents infectieux et au développement d’allergies. Une polarisation de l’immunité acquise vers des réponses de type Th2, productrices d’IL-4, d’IL-5 et d’IL-13, et un défaut de réponses immunes de type Th1, sécrétant de l’IFN-γ, peuvent rendre compte de ce statut immunitaire particulier. De plus, un retard de production et de maturation des anticorps, caractéristiques de l’immunité humorale, s’observe en début de vie. <p>Récemment, de nouveaux lymphocytes T auxiliaires ont été décrits, les lymphocytes Th17, producteur
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