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Dissertations / Theses on the topic 'Th2'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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1

Podgaec, Sérgio. "Padrões de resposta imune em pacientes com endometriose." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-31102006-105026/.

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Objetivo: O objetivo deste estudo foi analisar a relação e a predominância dos padrões de resposta imune Th1 e Th2 em pacientes com endometriose. Pacientes e Métodos: Entre Fevereiro de 2004 e Abril de 2005 foram avaliadas 98 pacientes divididas em dois grupos de acordo com a presença (Grupo A) ou ausência de endometriose (Grupo B), confirmada histologicamente. Foram coletados sangue periférico e fluido peritoneal de todas as pacientes para a dosagem de interleucinas (IL) 2, 4 e 10, fator de necrose tumoral-alfa (TNF-alfa) e interferon-gama (IFN-gama) por citometria de fluxo. Além da presença
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2

Strzelczyk, Barbara. "Cytokin mRNA profil i perifera mononukleära celler hos barn med födoämnesallergi." Thesis, Umeå universitet, Biomedicinsk laboratorievetenskap, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-58649.

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3

Rao, Venkata Lakshmi Prakruthi. "Epigenetic Reprogramming at the Th2 Locus." University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1543838686940608.

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4

Costa, Fernando Augusto Miranda da. "Resposta imune in vitro aos antígenos de Papilomavírus Humano (HPV) em homens na cidade de São Paulo, Brasil." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5133/tde-04022014-155625/.

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Introdução: O Papilomavírus Humano está muito bem associado com diversos tipos de cânceres humanos, como câncer anogenital e oral. Alguns estudos demonstram que o aparecimento de lesões e a progressão para o câncer estão relacionados ao tipo de resposta imune do hospedeiro. Deste modo, evidências indicam que a resposta imune do hospedeiro tem um papel muito importante para o curso da infecção pelo HPV. Objetivo: Avaliar a resposta imune específica in vitro ao Papilomavírus Humano (HPV) em homens com lesões causadas por HPV e sem lesão por HPV. Material e Métodos: Foram recrutados 31 pacientes
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5

Ahyi, Ayélé-Nati. "The role of PU.1 and IRF4 interaction in the biology and function of T helper 2 cells." Connect to resource online, 2009. http://hdl.handle.net/1805/1882.

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Thesis (Ph.D.)--Indiana University, 2009.<br>Title from screen (viewed on August 26, 2009). Department of Microbiology and Immunology, Indiana University-Purdue University Indianapolis (IUPUI). Advisor(s): Mark Kaplan. Includes vita. Includes bibliographical references (leaves 107-125).
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6

Persson, Marie, Christina Ekerfelt, Jan Ernerudh та ін. "Reduced IFN-γ and IL-10 responses to paternal antigens during and after pregnancy in allergic women". Linköpings universitet, Institutionen för klinisk och experimentell medicin, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-84900.

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Normal pregnancy and allergy are both characterized by a T helper (Th) 2 deviation. In the current study, we hypothesized that paternal antigen-induced cytokine responses during pregnancy would be deviated toward Th2 and an anti-inflammatory profile, and that the Th2 deviation would be more pronounced in allergic pregnant women. Blood samples were collected longitudinally on three occasions during pregnancy and two occasions post partum (pp). Of the 86 women initially included, 54 women had a normal pregnancy and completed the sampling procedures. Twelve women fulfilled the criteria for allerg
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7

Chiang, Sonnig Sue Whei. "Th1/Th2 imbalance in schizophrenia." Diss., lmu, 2005. http://nbn-resolving.de/urn:nbn:de:bvb:19-35074.

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8

Zhang, Ping. "The selective effect of dietary n-3 polyunsaturated fatty acids on murine Th1 and Th2 cell development." Diss., Texas A&M University, 2005. http://hdl.handle.net/1969.1/4148.

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To examine how dietary n-3 polyunsaturated fatty acids affect Th2 cell development, female C57BL/6 mice were fed a washout corn oil (CO) diet for 1 wk followed by 2 wk of either the same CO diet or a fish oil (FO) diet. CD4+ T cells were isolated from spleens and cultured under both neutral (anti-CD3 and phorbol myristate acetate (PMA)) and Th2 polarizing conditions (anti-CD3 and PMA, in presence of rIL-4, rIL-2, and anti-IFN-γ) in the presence of homologous mouse serum (HMS) or fetal bovine serum (FBS) for 2 d. Dietary n-3 PUFA significantly enhanced Th2 cell development and suppressed Th1
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Gonçales, Juliana Prado. "Associação entre a infecção pelo trichuris trichiura, produção de citocinas e doenças alérgicas das vias respiratórias (asma) em crianças da Região Metropolitana do Recife, Pernambuco." Universidade Federal de Pernambuco, 2015. https://repositorio.ufpe.br/handle/123456789/16508.

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Submitted by Fabio Sobreira Campos da Costa (fabio.sobreira@ufpe.br) on 2016-04-12T15:33:27Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Dissertacao_Final_Digital.pdf: 1044188 bytes, checksum: 49fcb98340d75c059b4fc044e603cce8 (MD5)<br>Made available in DSpace on 2016-04-12T15:33:27Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Dissertacao_Final_Digital.pdf: 1044188 bytes, checksum: 49fcb98340d75c059b4fc044e603cce8 (MD5) Previous issue date: 2015-02-27<br>CAPEs<br>A prevalência de doenç
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10

Kazak, Ilkay. "Th1-Th2-Zytokine bei entzündlicher Herzmuskelerkrankung." [S.l.] : [s.n.], 2002. http://www.diss.fu-berlin.de/2002/70/index.html.

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11

Morelli, Fernando Christiano Gabriel [UNESP]. "Quantificação de citocinas no conteúdo abomasal de bovinos de corte na presença ou ausência de ulceração gástrica." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/134249.

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Submitted by FERNANDO CHRISTIANO GABRIEL MORELLI null (fcgmorelli@yahoo.com.br) on 2016-02-12T17:49:35Z No. of bitstreams: 1 Fernando - Tese versão final Repositório UNESP.pdf: 1900802 bytes, checksum: a8c9044a1f5a46e203d3432398fc0a07 (MD5)<br>Approved for entry into archive by Sandra Manzano de Almeida (smanzano@marilia.unesp.br) on 2016-02-15T11:32:07Z (GMT) No. of bitstreams: 1 morelli_fcg_dr_araca.pdf: 1900802 bytes, checksum: a8c9044a1f5a46e203d3432398fc0a07 (MD5)<br>Made available in DSpace on 2016-02-15T11:32:07Z (GMT). No. of bitstreams: 1 morelli_fcg_dr_araca.pdf: 1900802 bytes, c
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Morelli, Fernando Christiano Gabriel. "Quantificação de citocinas no conteúdo abomasal de bovinos de corte na presença ou ausência de ulceração gástrica /." Araçatuba, 2016. http://hdl.handle.net/11449/134249.

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Orientador: Juliana Regina Peiró<br>Banca: Lina Maria Wehrle Gomide<br>Banca:Fernanda Bovino<br>Banca: José Paes de Oliveira Filho<br>Banca:Glenda Nicioli da Silva<br>Resumo: Erosões e úlceras são achados comuns no abomaso e causam preocupação econômica nos mais variados sistemas de produção de gado. Muitos fatores podem predispor ao aparecimento de úlceras e acúmulo de gases no abomaso, incluindo alimentos grosseiros, estresse ambiental, deficiências de vitaminas e minerais e infecções bacterianas. Essas úlceras podem ser subclínicas, sendo descobertas nas necropsias ou após o abate do animal
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13

Persson, Marie, Christina Ekerfelt, Barbara Jablonowska, et al. "Immunological status in patients undergoing in vitro fertilisation : responses to hormone treatment and relationship to outcome." Linköpings universitet, Institutionen för klinisk och experimentell medicin, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-85640.

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We aimed to prospectively investigate the paternal antigen-induced cytokine secretion by peripheral blood mononuclear cells (PBMCs) in response to hormone treatment in women undergoing in vitro fertilisation (IVF) and to examine the predictive value of the cytokine secretion profile in the outcome of IVF treatment, in a pilot study. Twenty-five women were included and IVF treatment was successful for six and unsuccessful for 19 women. Blood samples were collected before IVF treatment, on four occasions during IVF and four weeks after embryo transfer. The numbers of Th1-, Th2- and Th17-associat
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14

Lu, Thomas X. "MicroRNA in the Pathogenesis of Allergic Inflammation." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1329935942.

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15

Pinto, Kerollen Runa, and 92994459263. "Expressão heteróloga da enteroquinase em enzima Escherichia coli." Universidade Federal do Amazonas, 2017. https://tede.ufam.edu.br/handle/tede/6783.

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Submitted by Wendell Amoedo (wendell.amoedo@hotmail.com) on 2018-11-26T14:35:47Z No. of bitstreams: 1 dissertação.kerollen.runa.pinto2017.pdf: 1354749 bytes, checksum: 47321c0e5d660481ffc33d9d3204b2f0 (MD5)<br>Submitted by Wendell Amoedo (wendell.amoedo@hotmail.com) on 2018-11-28T13:01:00Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) dissertação.kerollen.runa.pinto2017.pdf: 1354749 bytes, checksum: 47321c0e5d660481ffc33d9d3204b2f0 (MD5)<br>Approved for entry into archive by Divisão de Documentação/BC Biblioteca Central (ddbc@ufam.edu.br) on 2
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Silveira, Denise Sayuri Calheiros da. "Papel funcional dos leucotrienos na resposta imunológica ao melanoma B16-F0 experimental em camundongos." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/60/60135/tde-28062012-144450/.

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No presente trabalho investigamos a relevância dos mediadores lipídicos (Leucotrienos) gerados pela enzima 5-Lipoxigenase (5-LO) na susceptibilidade ou resistência de camundongos ao Melanoma experimental com células tumorais B16-F0, utilizando como modelo camundongos produtores de leucotrienos (129_WT) e camundongos geneticamente deficientes \"knockout\" de 5-LO (129_5-LO KO). Primeiramente, verificamos que leucócitos peritoneais provenientes de animais WT implantados com melanoma B16-F0, apresentam aumento da expressão do gene para 5-LO (Alox5). Nossos resultados mostram que animais 5-LO KO,
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17

Triffaux, Emily. "Identification des canaux Cav1 impliqués dans la voie de signalisation calcique des lymphocytes Th2." Toulouse 3, 2013. http://thesesups.ups-tlse.fr/1959/.

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L'asthme est une maladie pulmonaire qui touche environ 10% de la population. Les lymphocytes T helper de type 2 jouent une rôle important dans la physiopathologie de l'asthme en produisant de l'interleukine 4,5,13. Mon équipe a montré dans une étude précédente que les cellules Th2 mais pas Th1 de souris exprimaient des canaux CaV1. Un oligonucléotide antisens (CaV1AS) inhibe la réponse calcique et la production de cytokines Th2 sous stimulation par le TCR sans toucher les cellules Th1 chez la souris. De plus, CaV1AS prévient l'asthme allergique expérimental. Durant ma thèse, j'ai montré que le
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18

Zhang, Shengtao. "Klonierung, Expression und initiale Charakterisierung vom humanen TIM3." Doctoral thesis, [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972570357.

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19

Marinho, Claudio Romero Farias. "Correlação entre a Carga Parasitária na Fase Aguda e a Intensidade da Patologia, Parasitismo e Ativação do Sistema Imune na Fase Crônica da Doença de Chagas Experimental." Universidade de São Paulo, 1998. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-11122007-114226/.

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0 objetivo deste trabalho foi definir se a carga parasitaria na fase aguda da doenga de Chagas experimental afeta a parasitemia, a patologia e a resposta imune na fase cr6nica. Para obtengelo de diferentes cargas parasitoirias na fase aguda, camundongos A/J foram infectados corn 103 OU 105 formas tripomastigotas de T. cruzi e analisados urn ano depois. Os animais cr6nicos infectados corn 105 formas tripomastigotas apresentaram maior nivel de parasitemia residual, maior intensidade de inflamagclo no coragtio e no moscuio esquel6tico e maior grau de ativa95o do sistema imune do que os animais
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20

Dwyer, Daniel Francis. "Effector roles of Granulocytes and B cells during Th2 Inflammation." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11580.

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Allergens are complex mixes of proteins and other compounds that have innate signaling capacity leading to Th2 inflammation. Understanding the role of each of these signals is essential to determining what separates allergens from innocuous proteins. Here, we examine two models for Th2 inflammation: infection with the helminth Trichinella spiralis and footpad immunization with papain, a cysteine protease structurally similar to proteases found in many common allergens including grass pollen and dust mites and helminth-secreted proteases secreted. Together, these studies highlight previously un
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Xiao, Yanping. "APRIL (TNFSF13) in Th1, Th2 and Th17 Responses." Scholarly Repository, 2009. http://scholarlyrepository.miami.edu/oa_dissertations/335.

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The T cell function of a proliferation inducing ligand (APRIL or TNFSF13) remains unclear. By comparing APRIL-/- mice with wild type (WT) mice, we have investigated the roles of APRIL in Th1, Th2 and Th17 responses. With regard to APRIL in Th1 responses, cultured APRIL-/- CD4+ T cells showed increased IFN-gamma production under non-polarizing, but not under Th1 polarizing, conditions. No difference in antigen-specific IgG2a levels existed between APRIL-/- and WT mice immunized with ovalbumin (OVA) and complete Freund's adjuvant (CFA) which induces Th1 polarization. Our data indicate that APRI
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22

Pearson, Joanne. "The pathological role of Th2 cytokines in artherosclerosis." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419321.

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23

Schulz, Kerstin Ingrid. "Modulation of Th1 and Th2 type immune responses." Thesis, University of Glasgow, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390690.

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Jonsson, Yvonne. "Cytokines and immune balance in preeclampsia : a survey of some immunological variables and methods in the study of preeclampsia." Doctoral thesis, Linköping : Linköpings universitet, 2005. http://www.bibl.liu.se/liupubl/disp/disp2005/med924s.pdf.

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25

Hamasato, Eduardo Kenji. "A influência da convivência com um parceiro doente sobre a resposta inflamatória alérgica pulmonar em camundongos." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/10/10133/tde-29092016-103925/.

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As relações bidirecionais entre o Sistema Nervoso e o Sistema Imune são relevantes para a manutenção da homeostase do organismo. Estudos realizados em nosso laboratório mostraram que 14 dias de coabitação com um conspecífico doente (injetado com células do tumor de Ehrlich-TAE) produziu mudanças comportamentais, endócrinas e imunológicas. Este estudo analisa os efeitos da convivência com um animal portador de tumor de Ehrlich em camundongos OVA sensibilizados e desafiados sobre a resposta alérgica pulmonar. Pares de camundongos machos foram separados em três grupos: naïve, controle e experimen
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Walwyn-Brown, Katherine. "Control of Th2 polarisation by dendritic cells and natural killer cells." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/control-of-th2-polarisation-by-dendritic-cells-and-natural-killer-cells(fd15f834-f926-40f1-88ff-217bf1fbf263).html.

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Type 2 (Th2) immune responses are required for immune defence against helminths, but can also have pathogenic effects in allergic conditions. This thesis examined two factors which may influence Th2 immunity at a cellular and molecular level: cross-talk between Natural Killer (NK) cells and dendritic cells (DCs) and the cell surface organisation of DCs. Cross-talk between NK cells and DCs is well-established to impact Th1 responses against tumours and infection; however the influence of this interaction during Th2 inflammation is unknown. To investigate this, human monocyte-derived DCs were st
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MERLOT, Élodie. "Modulation de la production de cytokines par l'environnement." Phd thesis, Institut national agronomique paris-grignon - INA P-G, 2003. http://tel.archives-ouvertes.fr/tel-00007518.

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Les conséquences immunitaires d'un stress d'origine environnementale sont complexes et encore difficilement prévisibles. Le stress affecte le système immunitaire soit en agissant sur l'immunité innée, en altérant la réactivité inflammatoire, soit en agissant sur l'immunité acquise, en modulant la production de cytokines dites Th1 et Th2. L'environnement social<br />contribue largement au développement et à l'expression de maladies. Dans les espèces sociales, la position sociale occupée dans le groupe module la susceptibilité aux infections mais les supports endocriniens et immunitaires de ces
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Espinosa, Karina. "CysLT1R modulation by Th1 Th2 and Th3 type cytokines in BSMC." Mémoire, Université de Sherbrooke, 2002. http://savoirs.usherbrooke.ca/handle/11143/3304.

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L'inflammation asthmatique chronique est caractérisée par le remodelage des voies aériennes, la dénudation de l'épithélium, l'épaississement des parois bronchiques, la fibrose sous-épithéliale, la métaplasie des glandes à mucus, ainsi que par l'hyperplasie et l'hypertrophie des muscles lisses bronchiques. Certaines études suggèrent un rôle possible pour les cystéinyl-leucotriènes (CysLTs) dans le remodelage des voies aériennes. Ce travail vise à caractériser la modulation du récepteur CysLT1 (CysLT1R) par des cytokines de type Th1, Th2 et Th3 dans un processus fonctionnel tel que le remodelage
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Bock, Cristin Nadine [Verfasser]. "Identification and characterization of murine and human Th2/1 hybrid cells in Th2-driven diseases / Cristin Nadine Bock." Berlin : Freie Universität Berlin, 2019. http://d-nb.info/1199343862/34.

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30

Hall, Gillian. "Approaches for the modulation of allergen-specific TH2 immunity." Thesis, University of Edinburgh, 2003. http://hdl.handle.net/1842/24666.

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The prevalence of allergic diseases, such as asthma, rhinitis, eczema and food allergies has increased dramatically over the last few decades and is now a major health and economic burden throughout the developed and developing worlds. Type I (immediate) hypersensitivity reactions are mediated by immunoglobulin E (IgE) responses directed against innocuous environmental antigens, such as pollen, housedust mites or animal dander. It is the resulting release of pharmacological mediators by IgE-sensitised mast cells that cause the symptoms of asthma and allergic rhinitis. The induction of IgE is d
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Lécart, Sandrine. "Caractérisation phénotypique et fonctionnelle des lymphocytes T auxiliaires humains, producteurs d'IL-10 : Th2 et T régulateurs (Tr)." Montpellier 1, 2002. http://www.theses.fr/2002MON1T004.

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UN MODELE IN VIVO D'INDUCTION DE REACTIONS D'HYPERSENSIBILITE CUTANEE, PROVOQUEES PAR L'HAPTENE DNCB, A ETE DEVELOPPE SUR DES SUJETS SAINS. IL A PERMIS L'ETUDE, IN VIVO, DE LA REGULATION INFLAMMATOIRE PAR L'APPARITION DE SOUS-POPULATIONS LYMPHOCYTAIRES T AUXILIAIRES DE TYPE 1, 2 ET T REGULATRICES (Tr), PRESENTANT DES PROFILS DE PRODUCTION CYTOKINIQUE STABLES ET SPECIFIQUES. PARMI LES DIFFERENTES MOLECULES DE SURFACE UTILISEES POUR CARACTERISER CES SOUS-POPULATIONS LYMPHOCYTAIRES T, NOUS AVONS MONTRE QUE LES RECEPTEURS A L'IL-12 ET A L'IFN-γ, EXPRIMES SPECIFIQUEMENT ET RESPECTIVEMENT SUR LES CE
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Kinyanjui, Margaret. "Targeting Th2 transcription factors in experimental asthma." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=18717.

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Antigen specific CD4+ T cells adoptively transfer airway inflammation comprised mainly of lymphocytes and eosinophils. The ability of these transferred T cells to induce inflammation is dependent on the cytokines they express particularly Th2 cytokines. In order to better understand the mechanism by which adoptively transferred T cells induce airway inflammation, we chose to modulate the expression (GATA-3) and activity (STAT-6) of two key regulators of Th2 cytokine production. To modify expression of GATA-3, we used a bicistronic retroviral vector encoding GATA-3 and enhanced green fluorescen
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Vallabh, Sushmitha. "Targeted Epigenetic Suppression of Th2 Cytokines Expression." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1505131225205869.

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34

Stock, Philippe [Verfasser]. "Immunregulation bei Th2 gerichteten Erkrankungen / Philippe Stock." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2009. http://d-nb.info/102349468X/34.

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35

Mukherjee, Sumanta. "LPS induced TH2 (Interleukin-4) cytokine production in macrophages and its regulation." University of Toledo Health Science Campus / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=mco1207743729.

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Persson, Marie, Christina Ekerfelt, Jan Ernerudh та ін. "Increased circulating paternal antigen-specific IFN-γ- and IL-4-secreting cells during pregnancy in allergic and non-allergic women". Linköpings universitet, Klinisk immunologi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-16134.

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INTRODUCTION: Allergic women have been reported to give birth to more children than non-allergic women, speculatively explained by the former's predisposition for Th2 polarization, possibly favoring pregnancy. AIM: The aim of this study was to test the hypothesis that allergy is associated with more Th2-deviated responses to paternal antigens throughout pregnancy. METHODS: Blood samples were collected on six occasions during pregnancy and two occasions postpartum (pp). Of the 86 women initially included, 54 women had a normal pregnancy and completed the sampling procedures. Eleven women fulfil
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Hu, Tuan Jun. "Tim family of molecules in the chicken : important differences from mammals." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/9621.

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T cell immunoglobulin and mucin (Tim) family molecules are cell membrane proteins with four functional Tim family members in mouse, and three in human. They are preferentially expressed on immune cells with Tim1 on Th2 cells, Tim3 on Th1 cells and Tim4 on antigen-presenting cells (APCs). They have several roles, including regulating immune responses and mediating phagocytosis of dead cells. However, little is known about them beyond these two species, and nothing outside mammals. To investigate the Tim family in the chicken, the genes were identified and cDNAs cloned. Differently to mammals, t
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Phythian-Adams, Alexander Thomas Luke. "Importance of dendritic cells during Schistosoma mansoni infection." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5288.

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Infection with the helminth parasite Schistosoma mansoni leads to chronic inflammation and Th2 mediated fibrosis, which result in severe pathology characterised by hepatosplenomegaly. Dendritic cells (DCs) are adept initiators of CD4+ T cell responses, but their fundamental importance in this regard in Th2 settings remains to be demonstrated. Indeed, the role of DCs at different stages of infection with S. mansoni is also yet to be determined. In addition, the importance of the interaction of DCs with tissue factors in the tissue microenvironment on the development of Th2 response to S. manson
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Bender, Orissa. "Untersuchungen zur Expression des TIM-3 Moleküls auf murinen T-Helfer-Zellen." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2003. http://dx.doi.org/10.18452/14915.

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Die von T-Helfer (Th) -Zellen produzierten Zytokine spielen eine entscheidende Rolle bei der Einleitung, der Aufrechterhaltung und der Regulation von Immunantworten. Bei der Untersuchung von Immunantworten hat sich eine vereinfachte Einteilung der Th-Zellen in zwei Klassen als hilfreich erwiesen: Th1 und Th2. Stabil differenziell exprimierte Oberflächenmoleküle werden benötigt, um lebende Th1- und Th2-Zellen identifizieren, auf Einzelzellebene charakterisieren und möglicherweise die von ihnen erzeugten Immunantworten modulieren zu können. Auf der Suche nach solchen Molekülen wurde in Zusammena
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40

Szymczak, Wendy A. "The Role Of Chemokines and Dendritic Cells In Regulation of IL-4 and Fungal Immunity." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1266607502.

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41

Gold, Wendy Anne Clinical School St Vincent's Hospital Faculty of Medicine UNSW. "Characterisation of inflammatory markers and the Th1/Th2 response in localized scleroderma." Awarded by:University of New South Wales. Clinical School - St Vincent's Hospital, 2008. http://handle.unsw.edu.au/1959.4/41534.

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Scleroderma is a chronic autoimmune connective tissue disease of unknown etiology characterized by excessive fibrosis and is broadly divided into two clinical entities: localized scleroderma (LSc) and systemic sclerosis (SSc). SSc is a multi-system disease resulting in both skin and visceral organ fibrosis. The more benign disorder, LSc is for the most part self-limited with the disease pathology being confined to the skin and subcutaneous tissues. Proposed factors involved in the pathogenesis of these disorders include endothelial cell injury and dysfunction, immunological alterations and inf
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42

Bruchard, Mélanie. "Etude de NLRP3 dans les cellules myéloïdes immunosuppressives et les lymphocytes TCD4 dans un contexte de cancer." Thesis, Dijon, 2013. http://www.theses.fr/2013DIJOS030/document.

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L’inflammasome NLRP3 est un complexe multiprotéique responsable notamment de la production d’IL-1β, une cytokine inflammatoire. Les effets délétères de l’inflammasome NLRP3 ont été démontrés dans de nombreuses maladies dont le cancer. Ce travail se concentre sur les effets de NLRP3 dans le contexte du cancer.Dans un premier projet, j’ai étudié l’activation de l’inflammasome NLRP3 dans les MSDC après un traitement par chimiothérapie. Deux chimiothérapies, le 5-Fluorouracile et la Gemcitabine, sont capables d’éliminer de façon spécifique les MDSC, population de cellules immunosuppressives dont l
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Janefjord, Camilla. "Th1, Th2 and Treg associated factors in relation to allergy." Doctoral thesis, Linköping : Linköpings universitet, 2006. http://www.bibl.liu.se/liupubl/disp/disp2006/med947s.pdf.

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44

Wan, Kong-Sang. "Regulation of lung Th1 and Th2 CD4'+T cell responses." Thesis, University of Southampton, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390720.

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45

Liddiard, Kate. "Macrophage Th2 cytokine-indiced gene expression in atherosclerosis." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289266.

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Nickdel, Mohammad Barat. "Role of Th2 cytokines in Toxoplasma gondii infection." Thesis, University of Strathclyde, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248258.

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Piehler, Daniel. "The inflammatory response against Cryptococcus neoformans is regulated by eosinophilic granulocytes and the interleukin-4/interleukin-4 receptor axis." Doctoral thesis, Universitätsbibliothek Leipzig, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-78248.

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Cytokines play an important regulatory role during immune responses against pathogens. The outcome of an induced cytokine pattern is determined by many factors. It strongly depends on the nature of the pathogen and the host’s ability to control the quality and strength of cytokine signals. In pulmonary infection with Cryptococcus neoformans T helper (Th) 1 and Th17 cell subsets and their associated cytokines confer protection, whereas a Th2-biased response with production of interleukin (IL) -4 confers susceptibility. Since inappropriate Th responses often lead to death in immunosuppressed hum
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48

Pereira, Leonardo Biscaro. "Avaliação do perfil de citocinas no tecido subcutâneo de camundongos na presença de cimento endodôntico." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/58/58135/tde-03102013-151254/.

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Avaliou-se a capacidade dos cimentos endodônticos: Sealapex®, Activ-GP® e AH-Plus® de alterarem o perfil das citocinas nas respostas Th1, Th2 e Th17, após a implantação destes em subcutâneo de camundongos. A quantificação das citocinas IL-2, IL-6, TNF-&alpha;, IFN-&gamma;, IL-4, IL-10 e IL-17 foi realizada in vivo, no tecido reacional circundante aos implantes, os quais foram confeccionados a partir de sondas nasogástricas estéreis e apirogênicas de cloreto de polivinila preenchidas com os cimentos, tendo um grupo controle com sondas vazias. Utilizou-se camundongos isogênicos da linhagem C57BL
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Gimsa, Ulrike. "T-Zell-vermittelte Autoimmunität." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2004. http://dx.doi.org/10.18452/13903.

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Die vorliegende Arbeit befaßt sich mit T-Helferzellen und ihren Interaktionen mit Gewebszellen, wie sie im gesunden Organismus und in Autoimmunerkrankungen auftreten. Es werden Fragen der Toleranzinduktion durch orale Gabe von Antigenen, speziell der oralen Verabreichung von Collagen II bei Patienten mit rheumatoider Arthritis diskutiert. Eine Immundeviation als Mittel, inflammatorische Th1-Zellantworten in anti-inflammatorische Th2-Zellantworten zu verwandeln, kann durch Eingriffe in die T-Zell-Signaltransduktion erreicht werden. Es werden neue Ansätze zu Mechanismen diskutiert, die das Immun
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Xiong, Ye. "KLF2: A Kruppel like Family Transcription Factor in Myeloid Cells Negatively Regulates Th2 Response." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1445343045.

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