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Journal articles on the topic 'Thalassemia'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Pattanapanyasat, Kovit, Kosol Yongvanitchit, Pongsri Tongtawe, et al. "Impairment of Plasmodium falciparum Growth in Thalassemic Red Blood Cells: Further Evidence by Using Biotin Labeling and Flow Cytometry." Blood 93, no. 9 (1999): 3116–19. http://dx.doi.org/10.1182/blood.v93.9.3116.

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Abstract Certain red blood cell (RBC) disorders, including thalassemia, have been associated with an innate protection against malaria infection. However, many in vitro correlative studies have been inconclusive. To better understand the relationship between human RBCs with thalassemia hemoglobinopathies and susceptibility to in vitro infection, we used an in vitro coculture system that involved biotin labeling and flow cytometry to study the ability of normal and variant RBC populations in supporting the growth of Plasmodium falciparum malaria parasites. Results showed that both normal and th

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2

Pattanapanyasat, Kovit, Kosol Yongvanitchit, Pongsri Tongtawe, et al. "Impairment of Plasmodium falciparum Growth in Thalassemic Red Blood Cells: Further Evidence by Using Biotin Labeling and Flow Cytometry." Blood 93, no. 9 (1999): 3116–19. http://dx.doi.org/10.1182/blood.v93.9.3116.409a37_3116_3119.

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Certain red blood cell (RBC) disorders, including thalassemia, have been associated with an innate protection against malaria infection. However, many in vitro correlative studies have been inconclusive. To better understand the relationship between human RBCs with thalassemia hemoglobinopathies and susceptibility to in vitro infection, we used an in vitro coculture system that involved biotin labeling and flow cytometry to study the ability of normal and variant RBC populations in supporting the growth of Plasmodium falciparum malaria parasites. Results showed that both normal and thalassemic

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3

Olivieri, O., L. De Franceschi, MD Capellini, D. Girelli, R. Corrocher, and C. Brugnara. "Oxidative damage and erythrocyte membrane transport abnormalities in thalassemias." Blood 84, no. 1 (1994): 315–20. http://dx.doi.org/10.1182/blood.v84.1.315.bloodjournal841315.

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Oxidative damage induced by free globin chains has been implicated in the pathogenesis of the membrane abnormalities observed in alpha and beta thalassemia. We have evaluated transport of Na+ and K+ in erythrocytes of patients with thalassemias as well as in two experimental models that use normal human red blood cells, one for alpha thalassemia (methylhydrazine treatment, alpha thalassemia like) and one for beta thalassemia (phenylhydrazine treatment, beta thalassemia like). With the exception of the Na-K pump, similar alterations in membrane transport were observed in thalassemia and thalass

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4

Olivieri, O., L. De Franceschi, MD Capellini, D. Girelli, R. Corrocher, and C. Brugnara. "Oxidative damage and erythrocyte membrane transport abnormalities in thalassemias." Blood 84, no. 1 (1994): 315–20. http://dx.doi.org/10.1182/blood.v84.1.315.315.

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Abstract Oxidative damage induced by free globin chains has been implicated in the pathogenesis of the membrane abnormalities observed in alpha and beta thalassemia. We have evaluated transport of Na+ and K+ in erythrocytes of patients with thalassemias as well as in two experimental models that use normal human red blood cells, one for alpha thalassemia (methylhydrazine treatment, alpha thalassemia like) and one for beta thalassemia (phenylhydrazine treatment, beta thalassemia like). With the exception of the Na-K pump, similar alterations in membrane transport were observed in thalassemia an

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5

Jha, R. "Distribution of hemoglobinopathies in patients presenting for electrophoresis and comparison of result with High performance liquid chromatography." Journal of Pathology of Nepal 5, no. 10 (2015): 850–58. http://dx.doi.org/10.3126/jpn.v5i10.15642.

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Background: Nearly 226 million carriers of thalassemias and abnormal hemoglobin are present worldwide according to the World Health Organization (WHO). The laboratory plays an important role in the investigation of the thalassemias and hemoglobinopathies. Cellulose acetate electrophoresis at alkaline pH and diagnosis based mainly on visual impression of thickness of band may miss the thalassemic trait patients. The aim of this study was to find out different hemoglobinopathies and thalassemia presenting in our hospital and to compare electrophoresis results with HPLC.Materials and Methods: Thi

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6

De Sanctis, Vincenzo. "CONCISE REVIEW ON THE FREQUENCY, MAJOR RISK FACTORS AND SURVEILLANCE OF HEPATOCELLULAR CARCINOMA (HCC) IN Β-THALASSEMIAS: PAST, PRESENT AND FUTURE PERSPECTIVES". Mediterranean Journal of Hematology and Infectious Diseases 12, № 1 (2020): e2020006. http://dx.doi.org/10.4084/mjhid.2020.006.

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Due to the recent alarming increase in the incidence of hepatocellular carcinoma (HCC) in thalassemias, the aim of the present report is to review briefly the frequency, the major risk factors and the surveillance of HCC in β-thalassemias. Over the past 33 years, 153 cases of HCC were reported in patients with thalassemia, mainly in Italy, and Greece. Among HCV-infected patients additional factors promoting development of HCC, included: advanced age, male sex, chronic hepatitis B (CHB) coinfection, and iron overload. For early diagnosis of HCC sequential ultrasound screening is recommended esp

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7

Tasnim, Sabrina, Tamanna Zahur, Sarah Fatima Sumaiya, et al. "Comparative Analysis of Craniofacial Parameters in Thalassemic Patients and Non-Thalassemic Individuals across Both Sexes in Chattogram, Bangladesh." Update Dental College Journal 15, no. 1 (2025): 9–14. https://doi.org/10.3329/updcj.v15i1.77925.

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Introduction: Thalassemia is a haematologic disorder impairing craniofacial development in inadequately treated patients. Research on craniofacial parameters in Bangladeshi thalassemic population comparing to non-thalassemics is scarce. This study aimed to determine the differences in craniofacial parameters if any between thalassemic patients and non-thalassemic individuals in Chattogram, Bangladesh across both sexes. Materials and methods: This cross-sectional analytical study was carried out among 100 respondents (50 transfusion dependent thalassemia patients and 50 non-thalassemic healthy

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8

Advani, R., S. Sorenson, E. Shinar, W. Lande, E. Rachmilewitz, and SL Schrier. "Characterization and comparison of the red blood cell membrane damage in severe human alpha- and beta-thalassemia." Blood 79, no. 4 (1992): 1058–63. http://dx.doi.org/10.1182/blood.v79.4.1058.1058.

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Abstract The aim of the present work was to understand the pathophysiology of the severe human thalassemias as represented by beta-thalassemia intermedia and hemoglobin (Hb) H (alpha-thalassemia) disease. We have previously shown that the material properties of the red blood cell (RBC) and its membrane differ in severe alpha- and beta-thalassemia, and we now show that this difference is probably caused by accumulation of alpha-globin chains at the cytoskeleton in beta-thalassemia, whereas beta-globin chains are associated with the cytoskeleton in alpha- thalassemia. In both alpha- and beta-tha

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9

Advani, R., S. Sorenson, E. Shinar, W. Lande, E. Rachmilewitz, and SL Schrier. "Characterization and comparison of the red blood cell membrane damage in severe human alpha- and beta-thalassemia." Blood 79, no. 4 (1992): 1058–63. http://dx.doi.org/10.1182/blood.v79.4.1058.bloodjournal7941058.

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The aim of the present work was to understand the pathophysiology of the severe human thalassemias as represented by beta-thalassemia intermedia and hemoglobin (Hb) H (alpha-thalassemia) disease. We have previously shown that the material properties of the red blood cell (RBC) and its membrane differ in severe alpha- and beta-thalassemia, and we now show that this difference is probably caused by accumulation of alpha-globin chains at the cytoskeleton in beta-thalassemia, whereas beta-globin chains are associated with the cytoskeleton in alpha- thalassemia. In both alpha- and beta-thalassemia,

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10

Sunarto, Sunarto. "Prenatal Diagnosis of Thalassemia." Paediatrica Indonesiana 33, no. 7-8 (2019): 191–9. http://dx.doi.org/10.14238/pi33.7-8.1993.191-9.

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Thalassemia is an individual as well as a community health problem in some countries. It causes a lifelong suffering for the affected individuals. There is no treatment other than supportive, i.e. regular transfusions and removal of iron overload from the body. Only by such continuous and expensive treatment thalassemic patients can-generally achieve nearly normal health, but the health burden of such therapy for a large number of thalassemic patients is unaffordable by the affected communities. Prevention of the births of thalassemic babies is the choice for controlling the thalassemia and ha

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11

Santos, Daniel Garcia, Marc Mikhael, Stefano Rivella, Monika Horvathova та Prem Ponka. "Heme Oxygenase 1 Plays a Role In The Pathophysiology Of β-Thalassemia". Blood 122, № 21 (2013): 3449. http://dx.doi.org/10.1182/blood.v122.21.3449.3449.

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Abstract Thalassemias are a heterogeneous group of red blood cell disorders ranging from a clinically severe phenotype requiring life-saving transfusions (thalassemia major) to a relatively moderate symptomatic disorder, sometimes requiring transfusions (thalassemia intermedia). Thalassemia minor, the least severe form of the disorder, is characterized by minimal to mild symptoms. While thalassemia minor and intermedia are vastly more prevalent than thalassemia major, the latter is often fatal when not treated. Though considered a major cause of morbidity and mortality worldwide, there is stil

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12

Villegas Martínez, A., A. F. González Fernández, P. Ropero Gradilla, J. Martínez Nieto, and C. Benavente Cuesta. "Treatment of beta Thalassemia. Can Thalassemia be cured?" ANALES RANM 141, no. 141(03) (2024): 241–47. https://doi.org/10.32440/ar.2024.141.03.rev05.

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Thalassemias are a very heterogeneous group of hereditary diseases characterized by a decreased or absent synthesis of a globin chain. According to the decreased or absent chain thalassemias are classified into β thalassemia, α thalassemia and other not so frequent types. The β-thalassemia can be a severe transfusion-dependent disease (TDT) requiring periodic scheduled transfusions throughout the patient’s life, as well as less severe forms called intermediate non-transfusion-dependent thalassemia (TNDT) and silent carriers or thalassemic trait, which are asymptomatic. Transfusion and chelatio

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13

Schrier, SL, E. Rachmilewitz, and N. Mohandas. "Cellular and membrane properties of alpha and beta thalassemic erythrocytes are different: implication for differences in clinical manifestations." Blood 74, no. 6 (1989): 2194–202. http://dx.doi.org/10.1182/blood.v74.6.2194.2194.

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Abstract To define how excess unpaired alpha- and beta-globin chains in severe beta-thalassemia and severe alpha-thalassemia interacting with the membrane might alter cellular and membrane properties, we performed a series of biophysical and biochemical analyses on erythrocytes obtained from affected patients. Detailed analysis of cellular and membrane deformability characteristics showed that both forms of thalassemic erythrocytes have excess surface area in relation to cell volume and increased membrane dynamic rigidity. The deformability characteristics of thalassemic erythrocytes in hypert

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14

Schrier, SL, E. Rachmilewitz, and N. Mohandas. "Cellular and membrane properties of alpha and beta thalassemic erythrocytes are different: implication for differences in clinical manifestations." Blood 74, no. 6 (1989): 2194–202. http://dx.doi.org/10.1182/blood.v74.6.2194.bloodjournal7462194.

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To define how excess unpaired alpha- and beta-globin chains in severe beta-thalassemia and severe alpha-thalassemia interacting with the membrane might alter cellular and membrane properties, we performed a series of biophysical and biochemical analyses on erythrocytes obtained from affected patients. Detailed analysis of cellular and membrane deformability characteristics showed that both forms of thalassemic erythrocytes have excess surface area in relation to cell volume and increased membrane dynamic rigidity. The deformability characteristics of thalassemic erythrocytes in hypertonic medi

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15

Garcia-Santos, Daniel, Amel Hamdi, Zuzana Zidova, Monika Horvathova та Prem Ponka. "Heme Oxygenase 1 Inhibition Reverses Anemia in β-Thalassemia Mice". Blood 128, № 22 (2016): 2462. http://dx.doi.org/10.1182/blood.v128.22.2462.2462.

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Abstract Thalassemias are a heterogeneous group of red blood cell (RBC) disorders ranging from a clinically severe phenotype requiring lifesaving transfusions (thalassemia major) to a relatively moderate symptomatic disorder, sometimes requiring transfusions (thalassemia intermedia). Though considered a major cause of morbidity and mortality worldwide, there is still no universally available cure for thalassemia major. The reason for this is, at least in part, due to the lack of full understanding of pathophysiology of thalassemia. The underlying basis of thalassemia pathology is the premature

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16

Garcia dos Santos, Daniel, Zuzana Zidova, Marc Mikhael, Amel Hamdi, Monika Horvathova, and Prem Ponka. "Pathophysiology and Treatment of Beta-Thalassemia: Investigations of Heme Oxygenase 1 and Its Inhibitors." Blood 126, no. 23 (2015): 3373. http://dx.doi.org/10.1182/blood.v126.23.3373.3373.

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Abstract Thalassemias are a heterogeneous group of red blood cell disorders ranging from a clinically severe phenotype requiring life-saving transfusions (thalassemia major) to a relatively moderate symptomatic disorder, sometimes requiring transfusions (thalassemia intermedia). Thalassemia minor, the least severe form of the disorder, is characterized by minimal to mild symptoms. Though considered a major cause of morbidity and mortality worldwide, there is still no universally available cure for thalassemia major. The reason for this is, at least in part, due to the lack of full understandin

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17

Garcia-Santos, Daniel, Marc Mikhael, Monika Horvathova та Prem Ponka. "Uncovering the Role of Heme Oxygenase 1 in the Pathophysiology of β-Thalassemia". Blood 124, № 21 (2014): 1364. http://dx.doi.org/10.1182/blood.v124.21.1364.1364.

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Abstract Thalassemias are a heterogeneous group of red blood cell disorders ranging from a clinically severe phenotype requiring life-saving transfusions (thalassemia major) to a relatively moderate symptomatic disorder, sometimes requiring transfusions (thalassemia intermedia). Thalassemia minor, the least severe form of the disorder, is characterized by minimal to mild symptoms. While thalassemia minor and intermedia are vastly more prevalent than thalassemia major, the latter is often fatal when not treated. Though considered a major cause of morbidity and mortality worldwide, there is stil

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18

Passat, Jimmy, Bulan Ginting Munthe, Fauzi Mahfuzh, and Taralan Tambunan. "Brainstem auditory evoked potentials features in thalassemia major." Paediatrica Indonesiana 41, no. 3 (2001): 166. http://dx.doi.org/10.14238/pi41.3.2001.166-70.

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Patients with thalassemia major are at high risk for hearing impairment. The objective of the study is to determine the prevalence, grade and type of hearing impairment according to brainstem auditory evoked potentials (BAEP) investigation in thalassemia major. A descriptive cross sectional study was conducted between December 1999 until August 2000 in 72 thalassemic patients between 3 and 18 years of age. Only 65 patients were evaluated, because of time limitation. The results showed the prevalence of hearing impairment in thalassemia major was 29.2%. Most of them were moderate to severe unil

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19

Shinar, E., O. Shalev, EA Rachmilewitz, and SL Schrier. "Erythrocyte membrane skeleton abnormalities in severe beta-thalassemia." Blood 70, no. 1 (1987): 158–64. http://dx.doi.org/10.1182/blood.v70.1.158.158.

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Abstract The protein composition of ghosts, inside-out vesicles (IOV), and membrane skeletons (MS) of erythrocytes (RBC) from splenectomized (spx) and nonsplenectomized (non-spx) patients with beta-thalassemia major and beta-thalassemia intermedia was determined. Ghosts from spx thalassemia intermedia patients had a significant increase in their globin content (which was mostly heme reactive) and contained extra polypeptides in the protein 4.2 to 5 and 6-globin areas. The Triton- extracted MS from all of the thalassemic patients showed two major abnormalities: they retained up to twice the amo

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Shinar, E., O. Shalev, EA Rachmilewitz, and SL Schrier. "Erythrocyte membrane skeleton abnormalities in severe beta-thalassemia." Blood 70, no. 1 (1987): 158–64. http://dx.doi.org/10.1182/blood.v70.1.158.bloodjournal701158.

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The protein composition of ghosts, inside-out vesicles (IOV), and membrane skeletons (MS) of erythrocytes (RBC) from splenectomized (spx) and nonsplenectomized (non-spx) patients with beta-thalassemia major and beta-thalassemia intermedia was determined. Ghosts from spx thalassemia intermedia patients had a significant increase in their globin content (which was mostly heme reactive) and contained extra polypeptides in the protein 4.2 to 5 and 6-globin areas. The Triton- extracted MS from all of the thalassemic patients showed two major abnormalities: they retained up to twice the amount of pr

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Ghany Ismaeel, Ayad. "Diagnose Mutations Causes Î’-Thalassemia: Biomining Method Using an Optimal Neural Learning Algorithm." International Journal of Engineering & Technology 8, no. 1.11 (2019): 1–8. http://dx.doi.org/10.14419/ijet.v8i1.11.28082.

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The problems in genome and proteome classification of mutations causing a thalassemia are synthesis, e.g. which thalassemia's database will choose? and then the technique that used in biomining to classify mutations causing thalassemia who can say is effective/optimal. This paper proposed genomics classification for Î²-thalassemiaâ€™s mutations in ITHALNET-IthaGenes database [1] (which is a modern and more comprehensive comparing to otherÂ thalassemia databases aboutÂ 63% of thalassemiaâ€™sÂ mutations) using data biomining method based on multipleÂ neural network learning algorithms (Conjugate

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22

Ridha Sp. A(K), M.Kes, Dr dr Nadirah Rasyid, Johan Gautama, and Idham Jaya Ganda. "ANALYSIS OF VITAMIN D LEVELS IN CHILDREN WITH THALASSEMIA BETA." International Journal of Health Science & Medical Research 1, no. 1 (2022): 46–60. http://dx.doi.org/10.37905/ijhsmr.v1i1.13585.

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Background : Beta Thalassemia is a genetic disorder inherited by autosomal recessive and has spread throughout the world, including Indonesia. Beta thalassemia requires lifelong transfusions, which can cause an accumulation of iron in the skin, liver, and kidneys, resulting in a decrease in vitamin D synthesis.Purpose : This study aims to analyze the levels of 25-OH-Vitamin D in beta thalassemia.Method : This study used a cross-sectional design and was conducted at Dr. Wahidin Sudirohusodo Hospital from April to July 2021. The population of this study was patients diagnosed with beta thalassem

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23

Barua, Tanuka, Dazy Barua, Dhananjoy Das, Rupam Talukdar, Razia Sultana, and Mahmood A. Chowdhury Arzu. "Knowledge and Awareness of Parents Toward Thalassemia." Chattagram Maa-O-Shishu Hospital Medical College Journal 20, no. 1 (2021): 12–15. http://dx.doi.org/10.3329/cmoshmcj.v20i1.53580.

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Background: Thalassemias are the most common heritable blood disorders that represents a major public concern. Poor awareness and lack of knowledge lead to increase number of carrier that is a silent reservoir of the disease. To observe the knowledge and awareness level of parents of thalassemic children about the disease. Materials and methods: This descriptive cross-sectional study was conducted in the Thalassemia ward of Chattogram Maa Shishu-O-General Hospital, Chattogram from July 2013 to June, 2014. Parents of 70 thalassemia patients aged 2-18 years interviewed with a formulated qu

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Syed Muhammad Ali, Syed Mahmood Haider, Kashif Ikram, Uzair Ahmed, Sana Ahmed, and Raza Ali. "Craniofacial growth Pattern of Thalassemia Major Patients in the haematological institutes of populations of Karachi Pakistan." Professional Medical Journal 31, no. 06 (2024): 988–93. http://dx.doi.org/10.29309/tpmj/2024.31.06.7704.

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Objective: To look at patients with -thalassemia's skeletal patterns. Study Design: Cross sectional, Observational. Setting: Karachi Medical and Dental College, Baqai Dental College Baqai Medical University, Husaini Institute of Heamatological Studies and Fatmid Foundation. Study Period: 2012 to 2020. Methods: Fifty patients with major thalassemia were voluntarily chosen at random, and 50 lateral cephalometric X-rays were taken using the Steiner Analysis inclusion criteria major Thalassemia Patient under 35 without any systemic disorders. exclusion criterion any additional forms of thalassemia

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Tritipsombut, Jaruwan, Kanokwan Sanchaisuriya, Supan Fucharoen та ін. "Hemoglobin Profiles and Hematologic Features of Thalassemic Newborns: Application to Screening of α-Thalassemia 1 and Hemoglobin E". Archives of Pathology & Laboratory Medicine 132, № 11 (2008): 1739–45. http://dx.doi.org/10.5858/132.11.1739.

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Abstract Context.—Thalassemia and hemoglobinopathies are major public health problems worldwide. To establish a cost-effective screening tool for newborns in regions where the incidence of these disorders is significant, study of the hemoglobin and hematologic features of normal and thalassemic newborns is necessary. Objective.—To study hemoglobin and hematologic characteristics of normal and various thalassemic newborns and to assess the effectiveness of simple screening methods for α-thalassemia 1 and hemoglobin E. Design.—Study was made of 402 cord blood specimens collected from unrelated T

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Șeicaru, D., Dorina Constantinescu, Corina Frecus, and D. Bulucea. "Heterozygous Beta-Thalassemia, A Genetic Haemolytic Anaemia In Continuous Expansion." Acta Medica Marisiensis 59, no. 3 (2013): 154–57. http://dx.doi.org/10.2478/amma-2013-0036.

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Abstract Introduction: Heterozygous β-thalassemia represents the mild form of the β-thalassemic syndromes, being compatible with normal lifetime. The importance of β-thalassemia consists in the fact that it maintains the "defective gene" in the population, favoring the appearance of new cases of Cooley's anaemia, the severe form of β-thalassemic syndromes. Current data estimate that 7% of the world's population is bearing β-thalassemia, over 400,000 children with β thalassemia being born annually, therefore the WHO estimates the doubling of this figure in the coming years. Material and methods

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Yeni, Hervita, Finny Fitry Yani, Amirah Zatil Izzah, and Gustina Lubis. "Relationship between serum ferritin and zinc levels in patients with major thalassemia." Paediatrica Indonesiana 59, no. 3 (2019): 144–9. http://dx.doi.org/10.14238/pi59.3.2019.144-9.

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Background In thalassemia patients, reduced zinc absorption results from increased serum iron due to repeated blood transfusions, increased iron absorption due to ineffective erythropoiesis, and competitive inhibition between iron and zinc in binding to transferrin, a means of transporting both types of minerals in the blood. Few studies have been done to examine zinc levels in thalassemia patients and its relationship with ferritin. Objective To compare serum zinc in thalassemia patients and healthy controls and to assess for a possible correlation between serum ferritin and zinc in tha

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Hsieh, Hsin-Yi, Lin-Chi Huang, Hong-Ren Yu, et al. "Pediatric thalassemic patients have higher incidence of asthma: A nationwide population-based retrospective cohort study." PLOS ONE 16, no. 11 (2021): e0258727. http://dx.doi.org/10.1371/journal.pone.0258727.

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Introduction Patients with hemoglobinopathies have been reported to have higher rates of pulmonary complications. Few studies have investigated the association between thalassemia and asthma in children. Methods We used the data of one million individuals randomly selected from the Registry for Beneficiaries of the National Health Insurance Research Database. One thalassemic child was matched with four control children without thalassemia according to sex, birth year, birth season, prematurity, and previous enteroviral infection. Results A total of 800 hundred thalassemic children and 3200 con

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Balakhanim, Amiraslanova, and Asadova Basti. "GENETIC EVALUATION OF THALASSEMIA DISEASE IN AZERBAIJAN." Annali d'Italia 64 (February 27, 2025): 4–6. https://doi.org/10.5281/zenodo.14937286.

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Thalassemias are a genotypically and phenotypically heterogeneous group of diseases. There are β-, α-, δ-, δβ– and γ-thalassemias, of which β– and δβ-thalassemias are of greatest practical interest for Uzbekistan. βthalassemia is the result of inhibition of beta-chain synthesis. In beta-thalassemia, there is an excess of alphapolypeptide chains. Homozygous beta-thalassemia is characterized by the appearance of clinical signs in the second half of the first year of a child's life. Patients often die in the neonatal period, some

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Abdullah, Dr Kahtan Adnan, Dr Mohammed Ahmed Jassim Alogaidi та Dr Raed Jabbar Hussain. "Study Tanner staging of β- thalassemic patients attending thalassemic Center in Ibn Al-Atheer Teaching Pediatric Hospital". Journal of University of Shanghai for Science and Technology 23, № 11 (2021): 583–89. http://dx.doi.org/10.51201/jusst/21/11944.

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Purpose: determine any relationship between tanner staging of the patients and transfusion program, iron overload and chelation therapy and study tanner staging of β- thalassemic patients attending Thalassemic Center in Ibn Al-Atheer Teaching Pediatric Hospital. Patients and Methods: A descriptive-analytic study (case series study) was done on β- thalassemic patients attending Thalassemia Center in Ibn Al- Atheer Teaching Hospital in Mosul, during the period from the 1st of January to the 30th of June 2019.Sixty patients with β- thalassemia, 45 of them are β- thalassemia major cases and 15 are

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MN, Islam, Kamruzzaman M, Sarker MH, Riaaz R, and Ilhan NS. "“The Parental Perspective of Thalassemia in Bangladesh: Challenges for Prevention and Management of Thalassemia”." Scholars Journal of Applied Medical Sciences 12, no. 05 (2024): 519–27. http://dx.doi.org/10.36347/sjams.2024.v12i05.003.

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Introduction: Thalassemia is a genetic blood disorder characterized by abnormal hemoglobin production, poses significant challenges for families worldwide. In Bangladesh, where the prevalence of thalassemia is notable, parents face unique hurdles in both preventing and managing this condition. Aim of the study: The aim of this study is to explore the parental perspective of thalassemia in Bangladesh, focusing on the challenges faced in the prevention and management of the disease. Methods: This was a cross section retrospective study conducted in the Department of Paediatrics of M Abdur Rahim

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Ittarat, Wanida, Sornchai Looareesuwan, Pensri Pootrakul, Petchmanee Sumpunsirikul, Phantip Vattanavibool та Steven R. Meshnick. "Effects of α-Thalassemia on Pharmacokinetics of the Antimalarial Agent Artesunate". Antimicrobial Agents and Chemotherapy 42, № 9 (1998): 2332–35. http://dx.doi.org/10.1128/aac.42.9.2332.

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ABSTRACT Thalassemia is common in Southeast Asia, where artemisinin derivatives are frequently used in the treatment of malaria. It has been previously reported that artemisinin derivatives can be concentrated by uninfected thalassemic erythrocytes in vitro but not by normal erythrocytes. As a follow-up to this report, we studied the antimalarial kinetics of intravascular artesunate (2.4 mg/kg of body weight) in 10 persons with normal hemoglobins and in 10 patients with thalassemia (2 with α-thalassemia type 1–hemoglobin Constant Spring and 8 with α-thalassemia type 1–α-thalassemia type 2). Co

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Apostoli, Anthony, Amanda Cipolla, Maureen Kinghorn, Jacob Kaufman, Giulia Muraca, and Nancy Olivieri. "Pregnancy in Thalassemia Patients and Their Partners in a Canadian Population." Blood 106, no. 11 (2005): 3835. http://dx.doi.org/10.1182/blood.v106.11.3835.3835.

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Abstract Although successful pregnancy is not an uncommon outcome in patients with homozygous beta thalassemia over the last 20 years, most of these have been reported in case reports and small series, while many publications do not appear to distinguish between pregnancies in thalassemia intermedia and those in thalassemia major. For example, of the total of 150 pregnancies in women with thalassemia reported in the literature from 1984 to 2004, 74 pregnancies appear clearly to be documented in patients with thalassemia major, while in the other 76, a reportedly late onset of transfusions sugg

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Dr., Atul Gopal Agrawal. "Perception of Parents of Children suffering from Thalassemia in Karimnagar District of Telangana state in India." International Journal of Medical Sciences and Academic Research 04, no. 01 (2023): 20–26. https://doi.org/10.5281/zenodo.7701268.

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<strong>ABSTRACT:</strong> Introduction: Thalassemias are a group of inheritable hemoglobinopathies where abnormal hemoglobin is synthesized leading to decreased hemoglobin levels in the body. Thalassemias are classified according to which chain of the hemoglobin molecule is affected. In α-thalassemias, production of the α-globins chain is affected, while in β-thalassemia, production of the β-globins chain is affected. Thalassemias are a grave menace in the modern world which need to be tackled effectively and quickly to improve the health status of people around the worl

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Perrine, Susan P. "Fetal Globin Induction—Can It Cure β Thalassemia?" Hematology 2005, № 1 (2005): 38–44. http://dx.doi.org/10.1182/asheducation-2005.1.38.

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Abstract The β thalassemias are one of a few medical conditions in which reactivation of a gene product that is expressed during fetal life can functionally replace a deficiency of essential proteins expressed at a later developmental stage. The fetal globin genes are present and normally integrated in hematopoietic stem cells, and at least one fetal gene appears accessible for reactivation, particularly in β° thalassemia. However, rapid cellular apoptosis from α globin chain precipitation, and relatively low levels of endogenous erythropoietin (EPO) in some β+ thalassemia patients contribute

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Mutar, Mohammed Tareq, Mustafa Majid, Ammar Jaleel, Ali Saad, Ali Abdulmortafea, and Hashim Talib. "Awareness among Parents of Beta Thalassemia Major and Intermedia Patients in Three Centers in Baghdad and Al-Nasiriyah, Iraq in 2017." International Journal of Medical Students 7, no. 1 (2019): 6–10. http://dx.doi.org/10.5195/ijms.2019.315.

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Background: Thalassemia is an autosomal recessive disease common in Iraq with a prevalence of 35.7 per 100000. Beta thalassemia major is a life-threatening condition with many complications which if not managed could cause death at an early age. This cross-sectional study aimed to assess the awareness of parents/caregivers of children with beta-thalassemia major and intermedia, as enhancing awareness is the first and the most important step in all prevention programs Methods: We conducted this study in three thalassemia centers (two in Baghdad and one in Al-Nasiriyah) from July 20th, 201

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Ali, Zena Hussain. "Prevalence and risk factors for hepatitis C virus in Beta thalassemic patients attending blood diseases center in Ibn- AL -Baladi Hospital, Baghdad." AL-Kindy College Medical Journal 14, no. 1 (2018): 42–49. http://dx.doi.org/10.47723/kcmj.v14i1.17.

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Background: Thalassemias are a group of heterogeneous genetic disorders, in which the rate of production of hemoglobin is partially or completely suppressed due to reduced rate of synthesis of α or β- chain Objectives: to estimate the prevalence of Hepatitis C infection among B thalassemia patients attending Ibn-AL-Baladi center of blood diseases in AL-Sader city, in AL-Resafa Quarter of Baghdad and to determine the possible risk factors. Type of the study: Cross- sectional study. Methods: A cross sectional study conducted on B Thalassemia patients attending the blood disease

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De Franceschi, Lucia, Mariarita Bertoldi, Alessandro Matte та ін. "Oxidative Stress andβ-Thalassemic Erythroid Cells behind the Molecular Defect". Oxidative Medicine and Cellular Longevity 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/985210.

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β-thalassemia is a worldwide distributed monogenic red cell disorder, characterized by the absence or reducedβ-globin chain synthesis. Despite the extensive knowledge of the molecular defects causingβ-thalassemia, less is known about the mechanisms responsible for the associated ineffective erythropoiesis and reduced red cell survival, which sustain anemia ofβ-thalassemia. The unbalance of alpha-gamma chain and the presence of pathological free iron promote a severe red cell membrane oxidative stress, which results in abnormalβ-thalassemic red cell features. These cells are precociously remove

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Solhi, Hasan, Mojgan Hashemieh, Mohammad Lorgard Dezfuli Nejad, Hamid Reza Khoddami Vishteh, and Maryam Rahmati Nejad. "Diagnostic value of fingerprint patterns: An explorative study on beta-thalassemia diagnosis." Bangladesh Medical Research Council Bulletin 36, no. 1 (2010): 27–31. http://dx.doi.org/10.3329/bmrcb.v36i1.4631.

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Rapid diagnosis of major ? thalassemia along with certain preventive measures is of utmost significance. The present study aims to compare the fingerprints in Major ? thalassemic patients (67) and in their parents (76 with minor thalassemia) with the normal fingerprints of control group (144). A forensic medical examiner determined fingerprint types of arch, loop, whorl and other types. Like normal individuals, loop fingerprint pattern was found to be the most common fingerprint type among thalassemic patients. However, the number of whorl fingerprints in all fingers in thalassemic patients wa

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Wahidiyat, Iskandar, A. H. Markum, M. Abdulsalam, and S. Muslichan. "Some Problems of Thalassemia in Jakarta." Paediatrica Indonesiana 18, no. 3-4 (2017): 100. http://dx.doi.org/10.14238/pi18.3-4.1978.100-8.

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Within 10 years (1964 - 1974) two hundred and twenty one thalassemic children were observed in the Department of Child Health, Medical School, University of Indonesia in Jakarta. They consisted of 119 cases of thalassemia major, 95 thalassemia Hb E disease, 6 Hb H disease and 1 thalassemia Hb S disease. The main treatment of thalassemia major is still blood transfusion. Splenectomy was performed on 29 children with thalassemia major and 26 cases with thalassemia Hb E disease. Splenectomy performed on cases before hypersplenism appeared, showed better results then those late cases who have alre

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Nuinoon, Manit, Kwanta Kruachan, Warachaya Sengking, Dararat Horpet, and Ubol Sungyuan. "Thalassemia and Hemoglobin E in Southern Thai Blood Donors." Advances in Hematology 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/932306.

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Thalassemia and hemoglobin E (Hb E) are common in Thailand. Individuals with thalassemia trait usually have a normal hemoglobin concentration or mild anemia. Therefore, thalassemic individuals who have minimum acceptable Hb level may be accepted as blood donors. This study was aimed at determining the frequency ofα-thalassemia 1 trait,β-thalassemia trait, and Hb E-related syndromes in Southern Thai blood donors. One hundred and sixteen voluntary blood donors, Southern Thailand origin, were recruited for thalassemia and Hb E screening by red blood cell indices/dichlorophenolindophenol precipita

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Vives-Corrons, JL, MA Pujades, A. Miguel-Garcia, A. Miguel-Sosa, and S. Cambiazzo. "Rapid detection of Spanish (delta beta)zero-thalassemia deletion by polymerase chain reaction." Blood 80, no. 6 (1992): 1582–85. http://dx.doi.org/10.1182/blood.v80.6.1582.1582.

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Abstract delta beta-Thalassemia and hereditary persistence of fetal hemoglobin (HPFH) are inherited disorders characterized by the persistent synthesis of fetal hemoglobin (HbF) during adult life. The Spanish type of delta beta-thalassemia is a mild thalassemic condition due to a large deletion starting at the Alu I repeat between the A gamma and delta-globin genes immediately 3′ to the RIH probe and extending 11 and 17 kb downstream of the 3′ endpoints of HPFH 1 and HPFH 2, respectively. Using probes from the Spanish (delta beta)zero- thalassemic DNA, the 3′ breakpoint region has been mapped

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Vives-Corrons, JL, MA Pujades, A. Miguel-Garcia, A. Miguel-Sosa, and S. Cambiazzo. "Rapid detection of Spanish (delta beta)zero-thalassemia deletion by polymerase chain reaction." Blood 80, no. 6 (1992): 1582–85. http://dx.doi.org/10.1182/blood.v80.6.1582.bloodjournal8061582.

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delta beta-Thalassemia and hereditary persistence of fetal hemoglobin (HPFH) are inherited disorders characterized by the persistent synthesis of fetal hemoglobin (HbF) during adult life. The Spanish type of delta beta-thalassemia is a mild thalassemic condition due to a large deletion starting at the Alu I repeat between the A gamma and delta-globin genes immediately 3′ to the RIH probe and extending 11 and 17 kb downstream of the 3′ endpoints of HPFH 1 and HPFH 2, respectively. Using probes from the Spanish (delta beta)zero- thalassemic DNA, the 3′ breakpoint region has been mapped to a poin

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Kuypers, Frans A., Jie Yuan, Rachel A. Lewis, et al. "Membrane Phospholipid Asymmetry in Human Thalassemia." Blood 91, no. 8 (1998): 3044–51. http://dx.doi.org/10.1182/blood.v91.8.3044.3044_3044_3051.

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Phospholipid asymmetry in the red blood cell (RBC) lipid bilayer is well maintained during the life of the cell, with phosphatidylserine (PS) virtually exclusively located in the inner monolayer. Loss of phospholipid asymmetry, and consequently exposure of PS, is thought to play an important role in red cell pathology. The anemia in the human thalassemias is caused by a combination of ineffective erythropoiesis (intramedullary hemolysis) and a decreased survival of adult RBCs in the peripheral blood. This premature destruction of the thalassemic RBC could in part be due to a loss of phospholip

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Sookaromdee, Pathum, and Viroj Wiwanitkit. "Association between Alpha-Thalassemia Carrier Prevalence and Incidence of COVID-19." Journal of Preventive, Diagnostic and Treatment Strategies in Medicine 1, no. 4 (2022): 252–54. http://dx.doi.org/10.4103/jpdtsm.jpdtsm_74_22.

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BACKGROUND: The association between COVID-19 incidence and genetic underlying is an interesting issue. The possible association between thalassemia and COVID-19 is proposed. In additional to beta-thalassemia, alpha-thalassemia is another important group of thalassemic disorder. MATERIALS AND METHODS: In this report, the authors present an observation on correlation between alpha-thalassemia 1carrier prevalence and incidence of COVID-19 from a tropical country in Southeast Asia that alpha-thalassemia is endemic. RESULTS: According to this study, there is no significant correlation and the calcu

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Eiden, Mary Kate, Abhinab Kc, Michael Evans, and Alexander A. Boucher. "Analysis of New Pediatric Thalassemia Diagnoses between 2010-2019 in a University System and Comparisons with Statewide Demography of Minnesota." Blood 136, Supplement 1 (2020): 25–26. http://dx.doi.org/10.1182/blood-2020-137597.

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Introduction Thalassemias are common inherited hematologic disorders worldwide, and with increasing migration, its prevalence evolves in different countries. However, community prevalence across most of the United States is unknown. Minnesota, particularly Minneapolis/St. Paul, has a relatively large community of immigrant families, with focal ethnic clusters of Karen and Hmong individuals from Southeast Asia, Liberia, and neighboring countries in Western Sub-Saharan Africa. Statewide data show that these ethnic minority populations have grown in the past decade; it is unknown whether thalasse

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Sodani, Pietro, David Gaziev, Paola Polchi, et al. "New approach for bone marrow transplantation in patients with class 3 thalassemia aged younger than 17 years." Blood 104, no. 4 (2004): 1201–3. http://dx.doi.org/10.1182/blood-2003-08-2800.

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Abstract When prepared for transplantation with busulfan (BU) 14 mg/kg and cyclophosphamide (CY) 120 to 160 mg/kg, patients with thalassemia in risk class 3, aged younger than 17 years, who receive transplants from HLA-identical donors, had a 30% incidence of transplant rejection with recurrence of thalassemia. This, relatively poor, outcome was ascribed to insufficient immune suppression or to inadequate eradication of the thalassemic marrow, or both. In an attempt to enhance both immune suppression and eradication of the thalassemic clones, hydroxyurea, azathioprine, and fludarabine were add

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Kavita Attri, Sonia Yadav, Sushma Maratha, et al. "A Review on Current Status of Blood Disorder: Thalassemia and its Treatment." Journal of Advanced Zoology 44, S-5 (2023): 1289–99. http://dx.doi.org/10.17762/jaz.v44is-5.1211.

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The most prevalent hereditary monogenic disorders that claim millions of lives globally are thalassemic syndromes. A thalassemia is an inherited condition, at least one parent must carry the disease's gene. Perhaps a genetic mutation/ defective globin chain or the loss of specific important gene segments is the main cause. Thalassemic illnesses started to strain the healthcare systems of several nations worldwide. Management of thalassemia is now seen as a lifelong treatment that requires continuous monitoring. In this review, we seek to compile and analyze recent research on thalassemia diagn

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Kamil Mohammed, Iyden. "Detection of some antioxidant markers in saliva of patients with beta thalassemia major." Al-Kufa University Journal for Biology 11, no. 1 (2019): 83–93. http://dx.doi.org/10.36320/ajb/v11.i1.8035.

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Background : Although evaluation and maintenance of antioxidant defence can be useful in protecting β-thalassemia patients from more serious complications of the disease, there are limited studies about assessment of antioxidant capacity in beta-thalassemic patients particularly in saliva.Methodology:Thirty patients with β thalassemia major were involved in this study in thalassemia center / Ebn- Albalady hospital in Baghdad, and fifteen normal subjects with matched age and sex were also involved and considered as control group. Age, gender, blood groups, BMI, secretory status, and antioxidant

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Basu, Subhangi, Motiur Rahaman, Tuphan Kanti Dolai, Praphulla Chandra Shukla та Nishant Chakravorty. "Understanding the Intricacies of Iron Overload Associated with β-Thalassemia: A Comprehensive Review". Thalassemia Reports 13, № 3 (2023): 179–94. http://dx.doi.org/10.3390/thalassrep13030017.

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β-thalassemia, a congenital genetic hematological disorder characterized by the decrease or absence of β-globin chains, leads to a decrease in levels of Hemoglobin A. The affected individuals can be categorized into two cohorts based on transfusion dependency: transfusion-dependent thalassemia (TDT) and non-transfusion-dependent thalassemia (NTDT). Remarkably, despite the primary pathology lying in β-globin chain depletion, β-thalassemia also exhibits an intriguing association with iron overload. Iron metabolism, a tightly regulated physiological process, reveals a complex interplay in these p

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