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1

Carlson, J. D., and J. F. Hancock. "A Methodology for Determining Suitable Heat-unit Requirements for Harvest of Highbush Blueberry." Journal of the American Society for Horticultural Science 116, no. 5 (1991): 774–79. http://dx.doi.org/10.21273/jashs.116.5.774.

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Fifteen years of Michigan harvest data for highbush blueberry (Vacciniun corymbosum L.) were used in conjunction with daily maximum and minimum temperatures to determine appropriate heat-unit models for first-picking dates of 13 cultivars. For each cultivar, an optimal heat-unit model was chosen after evaluating the performance of a standard method with 72 combinations of three variables: a) starting date for the heat-unit accumulations (SDATE), b) low-temperature threshold (TLOW), and c) high-temperature threshold (THIGH). The optimal model sought to include the most important criteria values
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2

Olivier, Hakizabera, Uwayezu Emmanuel, and Hirwa Gloria. "Weather influence on the performance of solar collector." International Journal of Sustainable Energy and Environmental Research 12, no. 1 (2023): 10–16. http://dx.doi.org/10.18488/13.v12i1.3379.

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A laboratory-scale evacuated tube solar collector (ETSCs) has been developed and tested for unloading conditions in Lanzhou, China. clear sky and cloudy conditions have been tested. Heat is generally considered instantaneous because it is a function of multiple instantaneous factors, like ambient temperature and solar radiation. The results show a clear sky day with a maximum and average value of ambient temperature, outlet, inlet, and solar radiation of 12 and -60C, 56 and 310C, 69 and 340C, 931 and 576W/m2, respectively, while a cloudy day was eight and -30C and 861.2 and 449W/m2 respectivel
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3

Biagioni, Cristian, Jiří Sejkora, Silvia Musetti, et al. "Stibiogoldfieldite, Cu12(Sb2Te2)S13, a new tetrahedrite-group mineral." Mineralogical Magazine 86, no. 1 (2022): 168–75. http://dx.doi.org/10.1180/mgm.2021.107.

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ABSTRACTStibiogoldfieldite, Cu12(Sb2Te2)S13, was approved as a new mineral species from the Mohawk mine, Goldfield mining district, Esmeralda County, Nevada, USA. It occurs as metallic anhedral grains, dark grey in colour. It is associated with quartz, pyrite and an Ag–Bi–(S,Se) phase (holotype material) and with quartz, pyrite, calaverite, bismuthinite, bohdanowiczite, and the Ag–Bi–(S,Se) phase (cotype material). In reflected light, stibiogoldfieldite is isotropic, grey in colour, with indistinct brownish shade. Reflectance data in air [R (%)] are: 31.1 at 470 nm, 30.9 at 546 nm, 30.8 at 589
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4

Mattous, Dr M., Dr N. Jebbar, Dr A. Diai, and Dr H. Kechna. "Severe Acute Pancreatitis: Management and Prognosis Experience of the Intensive Care Unit at Moulay Ismail Military Hospital Meknes, Morocco." SAS Journal of Medicine 10, no. 08 (2024): 785–90. http://dx.doi.org/10.36347/sasjm.2024.v10i08.015.

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Introduction: Severe acute pancreatitis is considered "a true ICU disease" as all organs can be affected either initially or secondarily. The overall mortality rate for acute pancreatitis of all forms is 4-10%, which can reach 30% in severe forms. The aim of our study was to reveal and describe the prognostic, epidemiological, clinical, paraclinical, and evolutionary factors of severe acute pancreatitis. Patients and Methods: This retrospective study focused on cases of severe acute pancreatitis admitted to the intensive care unit of Moulay Ismail Military Hospital in Meknes, Morocco, between
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5

Fuchs, A. F., F. R. Robinson, and A. Straube. "Participation of the caudal fastigial nucleus in smooth-pursuit eye movements. I. Neuronal activity." Journal of Neurophysiology 72, no. 6 (1994): 2714–28. http://dx.doi.org/10.1152/jn.1994.72.6.2714.

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1. We recorded single-unit activity from neurons of an output of the cerebellum, the fastigial nucleus, in two rhesus macaques while the monkeys tracked small moving targets with their eyes. Many neurons in the caudal part of the fastigial nucleus exhibited a modulation in their discharge rates when smooth-pursuit eye movements were elicited by either sinusoidal or step-ramp motions of a small target. 2. The pursuit direction that elicited the most vigorous modulation in unit firing to sinusoidal target motion could be horizontal, vertical, or oblique. Most often, the preferred direction was i
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Shapkina, Marina, Andrey Ryabikov, Ekaterina Mazdorova, et al. "The Determinants of the 13-Year Risk of Incident Atrial Fibrillation in a Russian Population Cohort of Middle and Elderly Age." Journal of Personalized Medicine 12, no. 1 (2022): 122. http://dx.doi.org/10.3390/jpm12010122.

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Atrial fibrillation (AF) is the most common arrhythmia and a predictor of the complications of atherosclerotic cardiovascular diseases (ASCVDs), particularly thromboembolic events and the progression of heart failure. We analyzed the determinants of the 13-year risk of incident AF in a Russian population cohort of middle and elderly age. A random population sample (n = 9360, age 45–69 years) was examined at baseline in 2003–2005 and reexamined in 2006–2008 and 2015–2017 in Novosibirsk (the HAPIEE study). Incident AF was being registered during the average follow-up of 13 years. The final analy
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Nanko, Doumbia, Sangaré Drissa, Keita Boubacar, et al. "Epidemiological Profile of Type 2 Diabetics Hospitalized at the Internal Medicine Unit of the Fousseyni Daou Hospital in Kayes, Mali." SAS Journal of Medicine 8, no. 4 (2022): 310–14. http://dx.doi.org/10.36347/sasjm.2022.v08i04.016.

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Diabetes is defined as a complex and chronic metabolic disorder characterized by a partial or total deficiency of insulin or, more commonly, by a decrease in the sensitivity of the target cells causing an increase in blood glucose. Objective: describe the profile of type 2 diabetic patients hospitalized in the department. Methodology: This is a retrospective descriptive study of 67 records of type 2 diabetic patients hospitalized from January 1 to December 31, 2020 in the Internal Medicine Unit of the Fousseyni Daou Hospital in Kayes. Result: We counted 67 diabetic patients hospitalized out of
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8

Naranjo, A., A. Molina, C. Rodriguez-Lozano, et al. "AB1220 VERTEBRAL FRACTURE CHARACTERISTICS IN AN FLS UNIT ACCORDING TO THE IDENTIFICATION METHOD; EMERGENCY LIST, OUTPATIENT CLINIC OR VFA." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1837.1–1837. http://dx.doi.org/10.1136/annrheumdis-2023-eular.1169.

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BackgroundThe risk o subsequent fracture is very high after a vertebral fracture (VF)ObjectivesTo analyze the characteristics of patients with VF seen in a Fracture Liaison Service (FLS).MethodsOur FLS cares for patients from the emergency list (URG), referred by hospital or primary care doctors (HPC) with VF <12 months, and captured by DXA-VFA (Densitometry - VF Assessment) in patients with non-VF. The database included the FRAX items plus previous treatment and DXA results. Traumatic VFs or VFs with a known age > 1 year, infiltrative or neoplastic diseases, and patients with contraindi
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Higashi, Masahiro, Naoaki Yamada, Satoshi Imakita, et al. "CT-pathologic correlation of non-calcified atherosclerotic arterial plaques: a study using carotid endarterectomy specimens." British Journal of Radiology 93, no. 1109 (2020): 20190901. http://dx.doi.org/10.1259/bjr.20190901.

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Objective: Pathologic features of atherosclerotic plaques on CT are not established. We compared CT values among pathologically confirmed plaque constituents and evaluated their ability to distinguish plaque constituents. Methods: 50 histopathological images of carotid endarterectomy samples from 10 males and 2 females (age 54–74 years, average 65.9 years) were examined. We compared pre-operative CT [pre-contrast (CT-P), early post-contrast phase (CT-E), delayed post-contrast phase (CT-D)] of lipid-rich necrotic core (NC) and fibrous tissue (F) plaque components with pathological images. The a
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10

Osipova, N., L. Bardenshteyn, N. Beglyankin, G. Aleshkina, and M. Dmitriev. "Structure of early signs of affective pathology in adolescents." European Psychiatry 64, S1 (2021): S631. http://dx.doi.org/10.1192/j.eurpsy.2021.1678.

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IntroductionStudies in adults with bipolar disorder (BD), shows that in 25% of cases first affective episode occurs under the age of 13 and in 63-69% under the age of 19. The most difficult problem is the early identification of BD, which starts in adolescence as a result of polymorphism of clinical symptoms, their syndromic incompleteness.ObjectivesStudy of the structure of adolescents affective disorders on primary appointment in outpatient psychiatric unit.MethodsContent analysis, sampling method, statistical method. 120 disease histories of adolescents who first applied for outpatient psyc
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Carlsen, Camilla H., Julia Kathrin Baumgart, Jan Kocbach, Pål Haugnes, Evy M. B. Paulussen, and Øyvind Sandbakk. "Framework for In-Field Analyses of Performance and Sub-Technique Selection in Standing Para Cross-Country Skiers." Sensors 21, no. 14 (2021): 4876. http://dx.doi.org/10.3390/s21144876.

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Our aims were to evaluate the feasibility of a framework based on micro-sensor technology for in-field analyses of performance and sub-technique selection in Para cross-country (XC) skiing by using it to compare these parameters between elite standing Para (two men; one woman) and able-bodied (AB) (three men; four women) XC skiers during a classical skiing race. The data from a global navigation satellite system and inertial measurement unit were integrated to compare time loss and selected sub-techniques as a function of speed. Compared to male/female AB skiers, male/female Para skiers displa
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Magala, Gloire, Muriel Tanoh, Abel Tanoh, et al. "Epidemiological Trends Related to Stroke and Neuroinfectious Diseases in Patients Admitted to the Neurology Unit at Cocody Teaching Hospital in Abidjan." European Journal of Preventive Medicine 12, no. 5 (2024): 121–31. http://dx.doi.org/10.11648/j.ejpm.20241205.12.

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Background: In Ivory Coast, as in many tropical regions, there is a significant coexistence of infectious diseases and non-communicable diseases (NCDs), particularly within the field of neurology. The dual burden of neuroinfectious diseases, including meningitis and strokes, plays a crucial role in shaping public health strategies implemented by the World Health Organization (WHO) and national health programs. Unfortunately, the epidemiological trends are not regularly updated. This study aims to provide insights into hospital admissions and mortality related to strokes and brain infections to
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Samanta, Prantik, Harald Horn, and Florencia Saravia. "Impact of Livestock Farming on Nitrogen Pollution and the Corresponding Energy Demand for Zero Liquid Discharge." Water 14, no. 8 (2022): 1278. http://dx.doi.org/10.3390/w14081278.

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Intensive livestock farming has negatively impacted the environment by contributing to the release of ammonia and nitrous oxide, groundwater nitrate pollution and eutrophication of rivers and estuaries. The nitrogen footprint calculator has predicted the large impact of meat production on global nitrogen loss, but it could not form the relationship between meat production and the corresponding manure generation. Here we report on the formation of direct relationships between beef, pork and poultry meat production and the corresponding amount of nitrogen loss through manure. Consequently, the e
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14

Thakkar, Snehal G., Zachariah A. McIver, Sanjay R. Mohan, et al. "Survival and Predictors of Outcome in Acute Leukemia Patients Admitted to the Intensive Care Unit." Blood 106, no. 11 (2005): 2778. http://dx.doi.org/10.1182/blood.v106.11.2778.2778.

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Abstract Background: Patients with acute leukemia fare poorly when admitted to intensive care units (ICUs). Predictors of outcome and rates of successful discharge have not been defined in the United States. Methods: This is a retrospective analysis of 78 acute leukemia patients admitted to the medical ICU from 2001–2004. Patients were identified by ICD-9 codes and a sudden increase in daily hospital charges (indicating a direct ICU admission or transfer to the ICU from a medical floor). The primary endpoints were improvement and subsequent ICU discharge with continued aggressive leukemia mana
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15

Savichan, Kyrylo. "Effectiveness of reactive hepatitis therapy in injured with ballistic wounds." Ukrainian Scientific Medical Youth Journal 131, no. 2 (2022): 61–69. http://dx.doi.org/10.32345/usmyj.2(131).2022.61-69.

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Reactive hepatitis complicates the treatment of ballistic wounds. The aim of our study was to study the clinical and pharmacoeconomic effectiveness of the treatment of reactive hepatitis in the wounded. A prospective study of 112 wounded servicemen with increased transaminase activity was randomized into three groups: group I received arginine glutamate intravenously for 10 days, group II received phosphatidylcholine intravenously for 10 days, and group III received standard treatment. In the presence of hypoalbuminemia, the wounded received intravenous infusions of albumin to normalize its le
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16

Ibrahim, John M., Paramjit Singh, Daniel Beckerman, et al. "Outcomes and Quality of Life Improvement After Multilevel Spinal Fusion in Elderly Patients." Global Spine Journal 10, no. 2 (2019): 153–59. http://dx.doi.org/10.1177/2192568219849393.

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Study Design: Retrospective case series. Objectives: Both the rate and complexity of spine surgeries in elderly patients has increased. This study reports the outcomes of multilevel spine fusion in elderly patients and provides evidence on the appropriateness of complex surgery in elderly patients. Methods: We identified 101 patients older than70 years who had ≥5 levels of fusion. Demographic, medical, and surgical data, and change between preoperative and >500 days postoperative health survey scores were collected. Health surveys were visual analogue scale (VAS), EuroQoL 5 Dimensions (EQ-5
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17

D. K. Vatsa and D. C. Saraswat. "Study on Plot Pattern and Farm Power Utilization for Major Crops in two Agro-climatic Zones of Hill Agriculture." Journal of Agricultural Engineering (India) 44, no. 3 (2007): 25–29. http://dx.doi.org/10.52151/jae2007443.1277.

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A study was conducted in two major agro-climatic zones of Himachal Pradesh, namely Sub-montaneous Low Hills Sub-tropical (Zone-I) and Mid Hills Sub-humid (zone-II), to know the plot pattern and power utilization for major crops i.e. maize, paddy and wheat in hill farming. Average percentage of plots was 9.1, 14.8,20.5, 25.3 and 30.3 in zone-I and 32.5, 26.4, 19.4, 14.2 and 7.6 in zone-II for the size less than 100, 100-00,200300, 300-400 and more than 400 m2, respectively. The vertical interval was observed to be 40-50 % higher in zone-II as compared to zone-I. The average plot width was 7.7,
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18

ORTIZ-MONASTERIO, J. I., and W. RAUN. "PAPER PRESENTED AT INTERNATIONAL WORKSHOP ON INCREASING WHEAT YIELD POTENTIAL, CIMMYT, OBREGON, MEXICO, 20–24 MARCH 2006 Reduced nitrogen and improved farm income for irrigated spring wheat in the Yaqui Valley, Mexico, using sensor based nitrogen management." Journal of Agricultural Science 145, no. 3 (2007): 215–22. http://dx.doi.org/10.1017/s0021859607006995.

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Wheat nitrogen-use efficiency in the Yaqui Valley has been estimated at about 0·31. The nitrogen that is not recovered by the crop has important environmental costs that have regional and global consequences. In addition, these nitrogen losses represent an important reduction in farm income. The objective of the present work was to validate a technology that includes the use of N-rich strips together with the GreenSeeker™ sensor and a crop algorithm in farmers' fields with the ultimate goal of improving nitrogen-use efficiency through site-specific nitrogen management in irrigated spring wheat
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19

Ricciardello, Daniel, Nam Kyu Yang, Kira Chamberlain, and Andrew Holland. "Firework and sparkler burns in paediatric patients." Australasian Journal of Plastic Surgery 4, no. 1 (2021): 30–34. http://dx.doi.org/10.34239/ajops.v4n1.240.

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Background: While the consumer sale of fireworks is illegal in New South Wales, the sale of sparklers is legal—however, both still pose a significant risk of harm in the paediatric population. Anecdotally, burns services are aware that the misuse of sparklers can result in burns but there appears to be a paucity of studies examining this incidence in the paediatric population in Australia.Method: A retrospective review of all burns related to the use of fireworks or sparklers referred to the Children’s Hospital at Westmead (CHW) Burns Unit (BU) from January 2004 to December 2019. Results: 96 p
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Buckley, Michael T., Joseph M. Lengfellner, Matthew J. Koch, et al. "MSK eConsent: Digitalizing the informed consent process to improve participant engagement and understanding." Journal of Clinical Oncology 38, no. 15_suppl (2020): 2066. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.2066.

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2066 Background: eConsent was developed to digitize the research participant consenting experience with an educational engagement model. The eConsent platform tiers consent document content in an easy-to-navigate format, using videos, images, and access to supplementary information. We hypothesize that enhancing the consenting experience improves participant engagement and comprehension. Methods: Here we present two projects: 1) qualitative assessment of patient engagement in the eConsent process using a standardized 5-question survey sent to all patients who used it during 9 months in 2019, a
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Scott, Lauren J., Niamh M. Redmond, Alison Tavaré, Hannah Little, Seema Srivastava, and Anne Pullyblank. "Association between National Early Warning Scores in primary care and clinical outcomes: an observational study in UK primary and secondary care." British Journal of General Practice 70, no. 695 (2020): e374-e380. http://dx.doi.org/10.3399/bjgp20x709337.

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BackgroundNHS England has mandated use of the National Early Warning Score (NEWS), more recently NEWS2, in acute settings, and suggested its use in primary care. However, there is reluctance from GPs to adopt NEWS/NEWS2.AimTo assess whether NEWS calculated at the point of GP referral into hospital is associated with outcomes in secondary care.Design and settingAn observational study using routinely collected data from primary and secondary care.MethodNEWS values were prospectively collected for 13 047 GP referrals into acute care between July 2017 and December 2018. NEWS values were examined a
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22

Glumcher, F. S., and Ye Yu Dyomin. "Noninvasive mechanical ventilation with helmet in patients with exacerbation of chronic obstructive pulmonary disease: a randomized controlled trial." Endovascular Neuroradiology 34, no. 4 (2020): 60–69. http://dx.doi.org/10.26683/2304-9359-2020-4(34)-60-69.

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Objective ‒ to compare the incidence of complications and the main treatment outcomes of non-invasive mechanical ventilation (NIV) with a helmet versus NIV with a full face mask.Materials and methods. A monocentric randomized open-labeled controlled clinical trial. Patients with exacerbation of chronic obstructive pulmonary disease (COPD) with signs of respiratory failure were randomized to receive NIV through a mask or helmet. The study included 59 patients who were randomized into two groups: NIV through helmet (n = 29) or mask (n = 30). The average age of the patients was (59.24 ± 14.20) an
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23

Slichter, Sherrill J., Jill Corson, Mary Kay Jones, et al. "Extended Storage of Autologous Apheresis Platelets (Plts) in Plasma and Plasmalyte." Blood 114, no. 22 (2009): 2108. http://dx.doi.org/10.1182/blood.v114.22.2108.2108.

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Abstract Abstract 2108 Poster Board II-85 Background: The FDA has proposed that, at the end of storage, radiolabeled autologous plt recoveries and survivals should be 67% and 58% respectively, of the same donor's “fresh” plt recovery and survival results. Methods: Using 98 normal subjects, 3 different variables were evaluated to determine their effects on post-storage plt recoveries and survivals; i.e., storage solution (plasma and Plasmalyte), apheresis machine [Haemonetics MCS+ (H), Cobe Spectra (CS), or Cobe Trima (CT)], and storage bag (H, CS, or CT). Autologous plts were collected and eit
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Tan, Harold Nathan, Marta Ascanio Morcillo, Johann S. De Bono, et al. "Adverse events of patients treated with antibody-drug conjugates in phase 1 clinical trials at the Royal Marsden Drug Development Unit from 2014 to 2024." Journal of Clinical Oncology 42, no. 16_suppl (2024): e15020-e15020. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e15020.

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e15020 Background: Antibody-drug conjugates (ADCs) are designed to improve therapeutic indices of cytotoxic agents. Nevertheless, they may induce unexpected toxicities not observed with parent payloads. This study aimed to characterize the adverse events (AEs) seen in patients treated with ADCs in Phase 1 trials at The Royal Marsden Drug Development Unit (DDU). Methods: This is a retrospective cohort analysis of consecutive patients who received at least one dose of an ADC in a phase I trial from January 2014 to January 2024 at The Royal Marsden DDU. Descriptive statistics of patient character
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25

Lyman, Gary H., Marek S. Poniewierski, Jeffrey Crawford, David C. Dale, and Eva Culakova. "Cost of Hospitalization in Patients with Cancer and Febrile Neutropenia and Impact of Comorbid Conditions." Blood 126, no. 23 (2015): 2089. http://dx.doi.org/10.1182/blood.v126.23.2089.2089.

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Background: Febrile neutropenia (FN) remains a serious complication of cancer chemotherapy often leading to hospitalization and an increased risk of mortality and cost. Methods: Data on hospitalizations between 2004 and 2012 at US academic medical centers and their affiliated hospitals reporting to the University Health Consortium were utilized. The analysis included admissions of adult patients (age ≥18 years) with lymphoma or solid tumors and neutropenia. For patients with multiple admissions, the first hospitalization during the time period studied was selected. Cancer diagnosis, presence o
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26

Cox, Carrie A., Vidhi Javia, Lisa C. Smith, Rachel C. Hill, and C. Scott Hultman. "774 Examination of the Religious and Spiritual Needs of Acutely Injured Burn Patients." Journal of Burn Care & Research 41, Supplement_1 (2020): S221. http://dx.doi.org/10.1093/jbcr/iraa024.352.

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Abstract Introduction Despite advances in burn care that dramatically increase survivability for severe burn injuries, individuals who suffer such injuries will likely experience long recovery periods complicated by declines in psychological, social, behavioral, occupational, and sexual functioning. We compared the self-importance of spirituality in a patient’s life with select demographic data in order to better understand the role of spirituality in the treatment and recovery of patients in the Burn Intensive Care Unit (BICU). Methods In this survey study and subsequent retrospective review,
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Kudek, Matthew R., Ryan Shanley, Nicole D. Zantek, Angela R. Smith, and Weston P. Miller. "The Impact of Graft/Recipient ABO Compatibility on Outcomes after Umbilical Cord Blood Transplant for Non-Malignant Disease." Blood 126, no. 23 (2015): 4369. http://dx.doi.org/10.1182/blood.v126.23.4369.4369.

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Abstract Background: Existing literature shows mixed conclusions regarding the impact of ABO incompatibility on outcomes following hematopoietic cell transplantation (HCT). As the future for umbilical cord blood (UCB) expansion technologies is bright, we assessed whether this typically-overlooked graft characteristic impacted various outcomes following UCB transplantation (UCBT) for non-malignant disorders (NMD). Patients and Methods: A prospectively maintained institutional BMT program database was queried for all patients undergoing first UCBT for NMD and their demographic, disease and trans
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Witkiewicz, Agnieszka, Emily Schultz, Erik S. Knudsen, and Ellis Levine. "Abstract P2-05-16: Interrogating serum thymidine kinase activity with CDK4/6 inhibitor-based therapies: real-world experience in the metastatic and adjuvant setting." Clinical Cancer Research 31, no. 12_Supplement (2025): P2–05–16—P2–05–16. https://doi.org/10.1158/1557-3265.sabcs24-p2-05-16.

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Abstract Background: CDK4/6 inhibitors have become widely deployed in the treatment of HR+/HER2- breast cancer. In the metastatic setting, a number of different CDK4/6 inhibitors are approved in combination with endocrine therapy and lead to a general doubling of progression-free survival (PFS). The CDK4/6 inhibitor abemaciclib is also employed in the adjuvant setting in the treatment of HR+/HER2- tumors at high risk for recurrence. The duration of response to these treatments is variable between individual patients supporting the use of biomarkers to predict time to progression/recurrence. He
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Brun-Strang, Catherine, Dora Bachir, Mariane De Montalembert, and Isabelle Thuret. "Socio-Economic Impact of Infused Iron Chelation Therapy in France: ISOSFER Study Results." Blood 108, no. 11 (2006): 3354. http://dx.doi.org/10.1182/blood.v108.11.3354.3354.

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Abstract Background: Patients suffering from β-thalassemia (TM), sickle cell disease (SCD), and myelodysplastic syndromes (MDS) undergoing chronic blood transfusions are at risk for iron overload which, if not treated by iron chelation therapy (ICT), can cause serious organ damage and reduce life expectancy. Deferoxamine (DFO) is the standard of care for the depletion of excess body iron. It has to be infused for 8–10 hours, 5–7 times a week. Although the clinical need for ICT is clearly established, less is known about the economic burden of DFO treatment. Aim: To estimate the total annual co
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30

Wang, Zhe, Anna Skwarska, Gowri Poigailwar, et al. "Efficacy of a Novel BCL-XL Degrader, DT2216, in Preclinical Models of Post-Myeloproliferative Neoplasm Secondary AML." Blood 144, Supplement 1 (2024): 2749. https://doi.org/10.1182/blood-2024-194031.

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Acute myeloid leukemia (AML) that evolves from myeloproliferative neoplasm (MPN), known as post-MPN secondary (s) AML, has a dismal prognosis, with current treatments failing to extend survival significantly beyond 12 months (Dunbar et. al., Blood 2020). B-cell lymphoma-extra-large (BCL-XL), an anti-apoptotic protein in the BCL-2 family, is overexpressed in MPN patients (Petiti et. al. J Cell Mol Med. 2020). This study investigated the role of BCL-XL in post-MPN sAML and evaluated the efficacy of DT2216 (kindly provided by Dialectic Therapeutics, Inc.), a platelet-sparing BCL-XL proteolysis-ta
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31

Aljitawi, Omar S., Siddhartha Ganguly, Tara L. Lin, et al. "Final Results of the First-in-Human Clinical Study Incorporating Hyperbaric Oxygen into Umbilical Cord Blood Transplantation." Blood 126, no. 23 (2015): 1909. http://dx.doi.org/10.1182/blood.v126.23.1909.1909.

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Abstract Background: Umbilical cord blood (UCB) transplantation is associated with delayed blood count recovery and engraftment. We have demonstrated that pre-treatment with hyperbaric oxygen (HBO) therapy to the recipient mice improved engraftment of intravenously infused human UCB CD34+ in a murine transplant model. Further studies from our laboratory attribute HBO effects on engraftment to HBO-induced low erythropoietin (EPO) state in the host, resulting in early UCB CD34+ cell bone marrow homing and an increase in myeloid to erythroid differentiation. These results lead to the first in-hum
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Zakwan Asrari and Taosige Wau. "Macroeconomics, sharia, and economic inequality in The Organization of Islamic Cooperation (OIC): An empirical study." Jurnal Ekonomi Syariah Teori dan Terapan 10, no. 3 (2023): 203–19. http://dx.doi.org/10.20473/vol10iss20233pp203-219.

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ABSTRACT This study aimed to determine the factors that influence the level of income inequality in member countries of the Organization of Islamic Cooperation (OC). The research period used was from 2012 to 2021, using the System Generalized Method of Moment (GMM) analysis tool. The variables used consist of the Gini ratio (proxy of income inequality), economic growth, Foreign Direct Investment (FDI), inflation, the average length of schooling (human capital proxy), and corruption perception index (sharia proxy). The results showed that sharia, human, and inflation variables had a negative ef
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Farrelly, Angelina, Louise Kelly, Naomi Davey, Josephine Soh, and Derek Hayden. "Impact of Early Comprehensive Geriatric Assessment on Unscheduled Acute Medical Admissions through an Age Related Assessment Unit." Age and Ageing 53, Supplement_4 (2024). http://dx.doi.org/10.1093/ageing/afae178.255.

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Abstract Background Older patients often face prolonged hospital stays, leading to increased healthcare costs and potential complications. Comprehensive geriatric assessment (CGA) at the point of hospital entry may reduce length of stay (LOS) by addressing the multifaceted needs of older patients promptly. This study evaluates the potential impact of early targeted CGA on the length of hospital stay for older patients admitted unscheduled to our hospital. Methods A retrospective review of all admissions by our Age Related Assessment Unit (ARAU) Team was conducted from January to April 2024. A
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Fairchild, Victoria C., Emily Powers, Lawrence Siew, Rakesh Mistry, Gunjan Tiyyagura, and Michael P. Goldman. "A Multiphase Quality Improvement Project to Increase Relative Value Unit Generation Through Documentation Practices in a Pediatric Emergency Department." Pediatric Emergency Care, July 15, 2025. https://doi.org/10.1097/pec.0000000000003445.

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Background: Documentation is essential to patient care, research, and financial sustainability. In our pediatric emergency department (PED), existing documentation practices contributed to financial deficits and decreased workplace satisfaction. Objective: To increase the monthly average relative value unit (RVU) per encounter by 10% over 2 years. Phase 1 aimed to reduce level of service (LOS) 99282 billing by 20%. Phase 2 targeted a 20% increase in LOS 99285 billing and aimed for 90% of admitted patients to be billed at LOS 99285. Methods: Using the Model for Improvement and iterative Plan-Do
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Bah, et al..., Malick. "TRAITEMENT CHIRURGICAL DES CANCERS DE L’OVAIRE A L’UNITE D’ONCOLOGIE DE DONKA." Journal Africain de Chirurgie 5, no. 3 (2019). http://dx.doi.org/10.61585/pud-jafrchir-v5n306.

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Introduction: To evaluate the results of surgical treatment of ovarian cancers at the Donka Oncology Surgery Unit. Patients and methods: This was a retrospective cohort of patients operated for histologically confirmed ovarian cancer from April 11, 2007 to December 31, 2017. Results: We collected 69 cases of ovarian cancer, of which 20 (28.98%) were operated on. The age ranged from 13 to 66 years with an average of 41.5 years; 45% were menopausal and 35% multiparous. The abdominopelvic pain and ascites were revealing respectively in 14 and 11 patients. The preoperative diagnosis was based on a
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Ödén, Jakob, Kjell Eriksson, Suryakant Kaushik, and Erik Traneus. "Beyond a constant proton relative biological effectiveness: A survey of clinical and research perspectives among proton institutions in Europe and the United States." Journal of Applied Clinical Medical Physics, November 3, 2024. http://dx.doi.org/10.1002/acm2.14535.

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AbstractPurposeAlthough proton relative biological effectiveness (RBE) depends on factors like linear energy transfer (LET), tissue properties, dose, and biological endpoint, a constant RBE of 1.1 is recommended in clinical practice. This study surveys proton institutions to explore activities using functionalities beyond a constant proton RBE.MethodsResearch versions of RayStation integrate functionalities considering variable proton RBE, LET, proton track‐ends, and dirty dose. A survey of 19 institutions in Europe and the United States, with these functionalities available, investigated clin
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Horiuchi, Yu, Alan S. Maisel, Dirk J. van Veldhuisen, et al. "Significance of an Early Repeat Troponin Measurement Upon Presentation to the Hospital for Acute Heart Failure." Journal of the American Heart Association, September 9, 2024. http://dx.doi.org/10.1161/jaha.124.034850.

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Background Higher cardiac troponin is associated with worse outcomes in patients with acute heart failure. The significance of repeat measurements over hours remains unclear. We assessed whether a repeat measurement and the Δ between measurements of high‐sensitivity cardiac troponin I (hs‐cTnI) were associated with outcomes in hypervolemic patients with acute heart failure without acute coronary syndrome. Methods and Results We analyzed 582 individuals from AKINESIS (Acute Kidney Injury Neutrophil Gelatinase‐Associated Lipocalin Evaluation of Symptomatic Heart Failure Study) with hs‐cTnI measu
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Griveas, Ioannis, Antonis Schinas, Anthoula Balitsari, Gerasimos Asimakopoulos, and Evangelos Pratilas. "MO862COVID-19 INFECTION IN HEMODIALYSIS PATIENTS:FINDINGS-EXPERIENCE-OUTCOME." Nephrology Dialysis Transplantation 36, Supplement_1 (2021). http://dx.doi.org/10.1093/ndt/gfab098.0054.

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Abstract Background and Aims Our Nephrology Department during spring period on the first wave of COVID-19 was the referral Dialysis Unit for Covid-19 positive HD patients in the district area of Athens, Greece. The aims of this study are to report characteristics, rates and outcomes of all patients affected by infection with SARS-CoV-2 undergoing HD and treated under our care Method This is an observational study. Our Dialysis Unit has been assigned as a referral unit for Covid-19 positive HD patients. We registered all the data regarding the clinical course of our patients population. Age, pr
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Fokin, Alexander A., Joanna Wycech Knight, Phoebe K. Gallagher, et al. "Characteristics and outcomes of trauma patients with unplanned intensive care unit admissions: Bounce backs and upgrades comparison." World Journal of Critical Care Medicine 14, no. 2 (2025). https://doi.org/10.5492/wjccm.v14.i2.101957.

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BACKGROUND The need for an emergency upgrade of a hospitalized trauma patient from the floor to the trauma intensive care unit (ICU) is an unanticipated event with possible life-threatening consequences. Unplanned ICU admissions are associated with increased morbidity and mortality and are an indicator of trauma service quality. Two different types of unplanned ICU admissions include upgrades (patients admitted to the floor then moved to the ICU) and bounce backs (patients admitted to the ICU, discharged to the floor, and then readmitted to the ICU). Previous studies have shown that geriatric
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Gleason-Comstock, Julie, Cindy Bolden Calhoun, Barbara J. Locke, et al. "People who use drugs engagement in substance use disorder services and harm reduction: evaluation, challenges and future direction of a community-based intervention." Substance Abuse Treatment, Prevention, and Policy 19, no. 1 (2024). http://dx.doi.org/10.1186/s13011-024-00601-1.

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Abstract Background Since 1996, an urban community-based organization whose primary mission is to serve diverse94 and emerging community health needs has provided screening, testing, overdose prevention and training, referrals, and access to treatment for substance use disorders (SUD) and communicable diseases such as HIV through its Life Points harm reduction program. Methods As a partner in a State survey in 2021, the community organization recruited a convenience sample of people who use drugs to participate in a survey focused on their substance use, healthcare, and barriers to SUD service
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Gibberd, Alison, Jessica Tyler, David Preen, et al. "Outcomes of Indigenous Twin and Singleton Pregnancies: Complications, Medical Care, Birth Experience and Infant Health." International Journal of Population Data Science 5, no. 5 (2020). http://dx.doi.org/10.23889/ijpds.v5i5.1592.

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IntroductionMultifetal pregnancies and births tend to be more complicated and have poorer outcomes than singleton pregnancies. Singleton pregnancies and perinatal outcomes are worse, on average, for Indigenous people than non-Indigenous people, but little is known about Indigenous multifetal pregnancies.
 Objectives and ApproachWe comprehensively describe and compare Indigenous twin and singleton pregnancies and births in Western Australia (WA) and New South Wales (NSW) and compare to NSW non-Indigenous pregnancies and births. Birth records and infant and maternal hospital records were li
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Rani, Humera, Gulwish Salahuddin, Ayesha Naz, Noreen Majeed, Faiza Safdar, and Shazia Rafique. "One-Year Review Of Reduced Fetal Movements In Izzat Ali Shah MCH Center: A Predictor Of Poor Perinatal Outcome." Journal of Rawalpindi Medical College 27, no. 2 (2023). http://dx.doi.org/10.37939/jrmc.v27i2.2015.

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Objectives: To find out common causes of reduced fetal movements. The purpose is to reduce perinatal morbidity and mortality.
 Methodology: This Prospective, Observational study was conducted at Izzat Ali Shah Maternal and child health center, unit III Gynae, Wah medical college Wah Cantt, from January 2019 to December 2019. A total of participants 160, who presented in the antenatal outpatient or emergency department with reduced fetal movements, were included in the study. Patients in the active phase of labor were excluded from the study. Patients were followed up till delivery. All ne
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Calvo Cordoba, R., A. Monzon Melian, E. Minguez De La Guia, et al. "Acute coronary syndrome in patients over ninety years old: should we rely solely on age?" European Heart Journal: Acute Cardiovascular Care 14, Supplement_1 (2025). https://doi.org/10.1093/ehjacc/zuaf044.108.

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Abstract Introduction Ischemic heart disease is the most common cardiovascular condition, and its presentation as myocardial infarction is one of the leading causes of morbidity and mortality in our region. Objectives The aim was to determine the prevalence of cardiovascular risk factors (CVRF), the presentation patterns, and the in-hospital evolution of acute myocardial infarctions with ST-segment elevation (STEMI) in nonagenarians. Methods We conducted a retrospective analysis of a total of 7,205 patients (p) admitted to the Cardiac Intensive Care Unit of our centre between 2012 and 2024. Re
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Vähä-Ypyä, Henri, Pauliina Husu, Kari Tokola, Harri Sievänen, and Tommi Vasankari. "O.4.2-10 What can one minute of the day tell about physical capacity?" European Journal of Public Health 33, Supplement_1 (2023). http://dx.doi.org/10.1093/eurpub/ckad133.185.

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Abstract Introduction High cardiorespiratory fitness (CRF) allows individuals to perform daily activities and operate at higher intensity levels. This study investigates the association between the CRF and peak intensity of physical activity (PA) in absolute and relative terms. Absolute intensity measures the amount of energy expended per unit of time during an activity, while relative intensity reflects the proportion of an individual's maximal capacity. Methods 1952 adults (803 men, 1149 women) aged 20-69 years participated in the FinFit2017-study. Their CRF was predicted with 6 min walking
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Linke, Christine, Elizabeth Prommer, and Claudia Wegener. "Gender Representations on YouTube." M/C Journal 23, no. 6 (2020). http://dx.doi.org/10.5204/mcj.2728.

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Introduction Media and gender are intricately linked in our society. Every day we see representations of women and men on the screen, read about politicians in the press, watch influencers on YouTube or go to the cinema where we meet screen heroes. Our images and notions of gender draw on these media narratives and role models. Children and young people are socialised with these views and cultivate their own identity and gender roles accordingly. Ideas of gender are not static. They are produced discursively in an ongoing process. Gender is understood as a social category, and this perspective
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Ameku, W.A., V.N. Ataide, E.T. Costab, et al. "A pencil-lead immunosensor for the rapid electrochemical measurement of anti-Diphtheria Toxin antibodies." October 30, 2021. https://doi.org/10.5281/zenodo.5628477.

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<strong>Abstract: </strong>Diphtheria is a vaccine-preventable disease, yet immunization can wane over time to non-protective levels. We have developed a low-cost, miniaturized electroanalytical biosensor to quantify anti-diphtheria toxin (DTx) immunoglobulin G (IgG) antibody to minimize the risk for localized outbreaks. Two epitopes specific to DTx and recognized by antibodies generated post-vaccination were selected to create a bi-epitope peptide, biEP, by synthesizing the epitopes in tandem. The biEP peptide was conjugated to the surface of a pencil-lead electrode (PLE) integrated into a po
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