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1

SAGIRAJU, Sruthi. "Liquid biopsy provides complementary information to tissue biopsies for molecular classification of DLBCL patients." Doctoral thesis, Università del Piemonte Orientale, 2022. http://hdl.handle.net/11579/144258.

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Diffuse large B-cell lymphoma is a molecular heterogeneous disease with a variable clinical course and prognosis. Recent studies have identified different molecular clusters on tissue biopsy. Liquid biopsy is a non-invasive tool that allows the collection of circulating tumor DNA (ctDNA) shed by apoptotic tumor cells potentially deriving from all the different sites of the lymphoma. This may provide an integrative source of tumor DNA for DLBCL genotyping. The aims of the study are: i) to identify new prognostic molecular markers on ctDNA and on lymph node biopsy (LN); and ii) to compare the DL
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2

Mackley, Emma Christine. "Investigating the role of innate lymphoid cells in secondary lymphoid tissue." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6479/.

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Innate lymphoid cells (ILCs) are an emerging family of cells which have been well-characterised within the gut and peripheral tissues. Despite being implicated in shaping adaptive immune responses, relatively little is known about their function within lymph nodes (LNs), important sites for the generation of this type of response. The aim of this investigation was to characterise ILC populations within a range of different LNs, both at steady state and using a draining LN model to understand their role in an immune response. Mice in which a subset of ILC, or key functional molecules, are defic
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Bollands, A. D. "Lymphoid tissue responses to emulsified perfluorochemicals." Thesis, University of Nottingham, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.381097.

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4

Moorthie, Sowmiya Anandan. "Disease-associated PrP in ruminant lymphoid tissue." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613754.

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5

Koornstra, Petra. "Waldeyer's ring equivalent lymphoid tissue in the rat a model for studying the immunological role of nose associated lymphoid tissue /." Maastricht : Maastricht : Universiteit Maastricht ; University Library, Maastricht University [Host], 1997. http://arno.unimaas.nl/show.cgi?fid=5912.

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6

Behbahani, Homira. "Immune dysregulation in HIV-1 infected lymphoid tissue /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-193-4.

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7

Zonios, George I. 1968. "Diffuse reflectance spectroscopy of human colon tissue." Thesis, Massachusetts Institute of Technology, 1998. http://hdl.handle.net/1721.1/29636.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Physics, 1998.<br>Includes bibliographical references (p. 129-134).<br>Diffuse reflectance spectroscopy can provide quantitative biochemical and morphological information for the analysis of biological tissue epithelium and the detection of precancerous lesions. To investigate this, diffuse reflectance spectra were collected from adenomatous colon polyps (cancer precursors) and normal colonic tissue of patients undergoing colonoscopy. To analyze the data, an analytical model was developed based on the diffusion of light in tissue
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8

Reel, Michael Stephen. "The Role of Ectopic Lymphoid Tissue in Allograft Rejection." Yale University, 2006. http://ymtdl.med.yale.edu/theses/available/etd-06282006-140255/.

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The location of the immunologic response to an allograft is not known with certainty. However, organized collections of T cells, B cells and antigen presenting cells have been found in peripheral tissue, in close proximity to organs undergoing rejection. It is hypothesized that this tertiary lymphoid tissue may be a location in which activation of lymphocytes can occur, leading to rejection of an allograft. We report here that in a splenectomized aly/aly mouse, which is devoid of secondary lymphoid organs and will normally fail to reject an allograft, the presence of tertiary lymphoid organs i
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9

Alden, Kieran. "Simulation and statistical techniques to explore lymphoid tissue organogenesis." Thesis, University of York, 2012. http://etheses.whiterose.ac.uk/3220/.

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Secondary lymphoid organs have a key role in the initiation of adaptive immune responses to infection. Organogenesis occurs in foetal development, and the use of genetic tools, imaging technologies, and ex vivo culture systems has provided significant insights into the cellular components and associated signalling pathways that are involved. However such approaches tend to be reductionist and descriptive, focusing on the contribution of individual components, and cannot fully explain how lymphoid organs develop through interaction between biological components. In this study, a set of simulati
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10

Olurinde, Mobolaji O. "Antigen-specific memory T cell distribution in non-lymphoid tissue." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/40951.

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Thesis (S.M.)--Massachusetts Institute of Technology, Biological Engineering Division, 2007.<br>Includes bibliographical references (leaves 28-34).<br>CD8+ T cells are the main adaptive immune system cell type responding to intracellular pathogens, particularly viruses, and tumor antigens. In the case of influenza, activated T cells migrate from the mediastinal (draining) lymph nodes to the lung where they perform their cytolytic function. After pathogen clearance, memory CD8+ T cells are generated, giving rise to long-term protection from reinfection. However, these cells are no longer detect
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11

Zhao, Mingjun. "NONINVASIVE MULTIMODAL DIFFUSE OPTICAL IMAGING OF VULNERABLE TISSUE HEMODYNAMICS." UKnowledge, 2019. https://uknowledge.uky.edu/cbme_etds/58.

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Measurement of tissue hemodynamics provides vital information for the assessment of tissue viability. This thesis reports three noninvasive near-infrared diffuse optical systems for spectroscopic measurements and tomographic imaging of tissue hemodynamics in vulnerable tissues with the goal of disease diagnosis and treatment monitoring. A hybrid near-infrared spectroscopy/diffuse correlation spectroscopy (NIRS/DCS) instrument with a contact fiber-optic probe was developed and utilized for simultaneous and continuous monitoring of blood flow (BF), blood oxygenation, and oxidative metabolism in
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12

Howard, Kenneth Alan. "The characterisation of the uptake of microparticulates across intestinal lymphoid tissue." Thesis, University of Nottingham, 1994. http://eprints.nottingham.ac.uk/11675/.

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Poly(lactide-co-glycolide) (PLG) biodegradable microparticles were evaluated as an oral delivery system for immunisation against equine influenza virus. Model particulates (fluorescent polystyrene and gold labelled polystyrene) were used to characterise the route and mechanism of intestinal uptake. Peyer's patches were found to be the site of particulate intestinal absorption characterised by phagocytosis at the M cell surface. Microparticles were found within intercellular compartments indicating a paracellular route for the transit of microparticles from lumen to lymph. A quantitative method
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13

Everitt, David Lewis. "Imaging of tissue-like media with diffuse light : analysis and optimization of a diffuse photon tomography /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2002. http://uclibs.org/PID/11984.

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14

Han, Shuhua. "β-lymphocyte differentiation in the periphery." Thesis, Imperial College London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326157.

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15

McMillan, Euan Murray. "Human lymphoid cell immunophenotypes : in situ immunochemistry of human lymphoid tissue, benign and malignant cutaneous lymphohistiocytic infiltrates with monoclonal antibodies." Thesis, University of Edinburgh, 1990. http://hdl.handle.net/1842/20012.

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This thesis describes the results obtained with 36 monoclonal antibodies (McAbs) and immunocytochemistry on a) non-malignant lymphoid tissue [thymus (1) (n) = number of specimens tested, lymph node (5), tonsil (15)]. b) 104 skin biopsies of cutaneous lymphoma (40), contact dermatitis (14), parapsoriasis (17), chronic inflammatory dermatosis (9), non-lymphomatous erythroderma (3), atypical lymphocytic infiltrate (3), granulocytic sarcoma (1), lymphocytoma (3), lymphomatoid papulosis (3), lymphocytic infiltrate of Jessner (1), chronic lymphocytic leukaemia (1), myelomonocytic leukaemia (1), hist
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16

Hedden, Jane Ann. "CHARACTERIZATION OF LYMPHOID CELLS IN GOATS WITH CASEOUS LYMPHADENITIS (LECTINS)." Thesis, The University of Arizona, 1985. http://hdl.handle.net/10150/275421.

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17

Mader, Emma. "The role of NF-kB2 in secondary and tertiary lymphoid tissue development." Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/1608/.

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The role of the alternative NF-\(\kappa\)B pathway in the development of secondary lymphoid organs (SLOs) has been well described. Tertiary lymphoid organs (TLOs) include intestinal cryptopatches (CPs) and isolated lymphoid follicles (ILFs). This thesis investigates the role of the alternative NF-\(\kappa\)B pathway in the development of colonic ILFs, using the p100\(\Delta\) mouse model, where the alternative pathway is constitutively active. We present compelling data that p100\(\Delta\) mice develop significantly more lymphoid aggregates in the colon, compared with WT littermates, and provi
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18

Kanth, Sheeba Irshad. "Role of RORyt+ innate lymphoid tissue inducer cells within breast cancer microenvironments." Thesis, King's College London (University of London), 2014. https://kclpure.kcl.ac.uk/portal/en/theses/role-of-roryt-innate-lymphoid-tissue-inducer-cells-within-breast-cancer-microenvironments(da9aadf1-96ff-4269-b2c8-f8278af18822).html.

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Within invasive breast cancers, lymphatic invasion is thought to be the first step tumour cells undertake when metastasizing through the lymphatic vasculature. The presence of lymphatic metastasis has been shown to stratify breast cancer phenotypes into distinct prognostic groups. The exact molecular mechanisms mediating tumour cell entry and dissemination within the lymphatic system remain unclear. We report the first identification of RORyt+-innate lymphoid tissue inducer (LTi) cells within the human breast cancer tumour microenvironment and the enrichment of lymphoid chemokines/chemokine re
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19

Sauvage, Vincent. "Fluorescence and diffuse reflectance spectroscopy and endoscopy for tissue analysis." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/10736.

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Biophotonics techniques are showing great potential for practical tissue diagnosis, capable of localised optical spectroscopy as well as wide field imaging. Many of those are generally based on the same concept: the spectral information they enable to acquire encloses clues on the tissue biochemistry and biostructure and these clues carry diagnostic information. Biophotonics techniques present the added advantage to incorporate easily miniaturisable hardware allowing several modalities to be set up on the same systems and authorizing their use during minimally invasive surgery (MIS) procedures
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20

Zanfardino, Sara Marie. "SENSITIVITY OF DIFFUSE CORRELATION SPECTROSCOPY TO FLOW RATES IN TISSUE-SIMULATING OPTICAL PHANTOMS." Miami University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=miami1533076561913823.

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21

Coleman, Leslie Ann. "Immunophenotypic characterization of lymphoid tissue and lymphoproliferative disease in ferrets (Mustela putorious furo)." Thesis, Massachusetts Institute of Technology, 1997. http://hdl.handle.net/1721.1/43442.

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22

Glanville, Stephanie Helen. "Analysing the role of lymphotoxin signalling in the development of lymphoid tissue microenvironments." Thesis, University of Birmingham, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.532169.

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The formation of lympho-stromal microenvironments in primary and secondary lymphoid tissues is crucial for the correct and efficient functioning of the immune system. Induction and maintenance of these environments in the spleen requires lymphotoxin (LT)-dependent lymphostromal and Lymphoid Tissue inducer cell (LTi) -stromal interactions resulting in the secretion of chemokines. In contrast the LT-dependence of the thymus is unclear. We have developed an in vivo model to study the formation of splenic microenvironments by grafting embryonic spleens under the kidney capsule of adult mice. These
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23

McGovern, Gillian. "Immunocytochemical and ultrastructural studies of lymphoid tissue of scrapie infected mice and sheep." Thesis, University of Edinburgh, 2004. http://hdl.handle.net/1842/30477.

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The transmissable spongiform encephalopathies (TSEs) are a group of progressive neurological diseases of unknown cause. Infection is associated with an abnormal form of a host protein designated ‘prion protein’. Previous studies have shown that lymphoid tissues are involved in the peripheral pathogenesis of TSEs prior to neuroinvasion. Using immunoelectron microscopy, disease specific PrP (PrP<sup>d</sup>) accumulation was demonstrated within the spleens of scrapie-infected mice where it was found in association with the plasmalemma and extracellular space around follicular dendritic cell (FDC
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24

Bergomas, Francesca. "Tertiary lymphoid tissue in colorectal cancer : a key player of the immune microenvironment." Thesis, Open University, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.701365.

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Tumour infiltrating Iymphocytes influence colorectal cancer (CRC) progression. However, Iymphocyte infiltration comes in different flavours and evidence has been provided that the spatial distribution of immune cells within the tumour tissue is an important immunological feature. The aim of this thesis was to investigate how the dual localization of tumour infiltrating Iymphocytes (TILs) can affect their function in the tumour microenvironment. The project started with the analysis of the CD3 compartment, as CD3+ T cell infiltration (C03-TILs) is a recognized positive prognostic factor for CRC
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25

Nagarajan, Vivek Krishna. "REAL-TIME ASSESSMENT OF THERMAL TISSUE DAMAGE USING DIFFUSE REFLECTANCE SPECTROSCOPY." University of Akron / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=akron1494313847936136.

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26

Masjedi, Mohsen. "Physiological inflammation of the small intestine during weaning in the rat /." Title page, table of contents and summary only, 1998. http://web4.library.adelaide.edu.au/theses/09PH/09phm3973.pdf.

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27

Orr, L. E. "Raman spectroscopy of laryngeal and lymphoid tissue : an application in optical diagnosis of malignancy." Thesis, Cranfield University, 2010. http://dspace.lib.cranfield.ac.uk/handle/1826/4528.

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The use of Raman spectroscopy in the detection and classification of malignancy within the human larynx and lymph nodes of the head and neck has been evaluated. Currently histopathology is considered the diagnostic gold standard. The potential for Raman spectroscopy to be used as an in vivo diagnostic tool in the detection of dysplasia and malignancy has been demonstrated. A consensus opinion from three expert histopathologists has been obtained and spectral diagnostic models developed by correlation with these results. The ability of Raman spectroscopy to differentiate between disease entitie
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28

Tawadros, Fady, Sakshi Singal, Maria Zayko, and Devapiran Jaishankar. "Mucosal Associated Lymphoid tissue of the Skin, A Common Entity in a Rare Location." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/asrf/2019/schedule/55.

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Marginal zone (MZ) lymphomas (MZLs) represent a group of lymphomas originating from B lymphocytes of the “marginal zone” which is the external part of the secondary lymphoid follicles. The WHO classifies MZL into 3 entities; extranodal MZL, splenic MZL and nodal MZL. Extranodal marginal zone lymphoma (EMZL) can arise in different tissues, including the stomach, salivary gland, lung, small bowel, thyroid, ocular adnexa and skin. We present a 25 years old female with a history of angioedema and chronic cutaneous eczema who developed an unusual EMZL. Patient presented with a history of rapidly en
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29

Farzam, Parisa. "Hybrid diffuse optics for monitoring of tissue hemodynamics with applications in oncology." Doctoral thesis, Universitat Politècnica de Catalunya, 2014. http://hdl.handle.net/10803/283982.

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Noninvasive measurement of hemodynamics at the microvascular level may have a great impact on oncology in clinics for diagnosis, therapy planning and monitoring, and, in preclinical studies. To this end, diffuse optics is a strong candidate for noninvasive, repeated, deep tissue monitoring. In this multi-disciplinary, translational work, I have constructed and deployed hybrid devices which are the combination of two qualitatively different methods, near infrared diffuse optical spectroscopy (NIRS) and diffuse correlation spectroscopy (DCS), for simultaneous measurement of microvascular total
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Nardini, Elena. "Characterization of genetic events involving IgH switch regions in gastric low grade MALT lymphomas and B CLL." Thesis, Open University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251405.

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31

Satou, Yuuki. "Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney." 京都大学 (Kyoto University), 2017. http://hdl.handle.net/2433/225471.

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32

Cooley, Lauren Folgosa. "The role of ADAM10, ADAM17, and Spag6 in humoral immunity and secondary lymphoid tissue architecture." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3808.

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ADAM10, ADAM17, and SPAG6 contribute significantly to humoral immunity and secondary lymphoid tissue architecture. ADAM10 and ADAM17 are two closely related zinc-metalloproteinases. Through cleavage of their ligands CD23 and TNF, respectively, they greatly influence IgE production and secondary lymphoid tissue architecture maintenance. Th1 prone WT strains initially exhibit increased ADAM17 and TNF yet reduced ADAM10 relative to Th2 prone WT strains. In the absence of B cell ADAM10, a compensatory increase in ADAM17 and TNF cleavage is noted only in Th1 prone C57Bl/6, not Th2 prone Balb/c. B c
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33

Häggblad, Erik. "In Vivo Diffuse Reflectance Spectroscopy of Human Tissue : From Point Measurements to Imaging." Doctoral thesis, Linköpings universitet, Biomedicinsk instrumentteknik, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-15191.

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This thesis presents the non-invasive use of diffuse reflectance spectroscopy (DRS) to provide information about the biochemical composition of living tissue. During DRS measurements, the incident, visible light is partially absorbed by chromophores but also scattered in the tissue before being remitted. Human skin and heart, the main tissue objects in this thesis, are dependent on a sufficient inflow of oxygenized blood, and outflow of metabolic byproducts. This process could be monitored by DRS using the spectral fingerprints of the most important tissue chromophores, oxyhemoglobin and deoxy
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34

Irwin, Daniel. "INFLUENCE OF TISSUE ABSORPTION AND SCATTERING ON DIFFUSE CORRELATION SPECTROSCOPY BLOOD FLOW MEASUREMENTS." UKnowledge, 2011. http://uknowledge.uky.edu/gradschool_theses/136.

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This investigation evaluates the influences of optical property assumptions on nearinfrared diffuse correlation spectroscopy (DCS) flow index measurements. Independent variation is induced in optical properties, absorption coefficient (μa) and reduced scattering coefficient (μs’), of liquid phantoms with concurrent measurements of flow indices. A hybrid instrument is incorporated consisting of a dual-wavelength (785 and 830 nm) DCS flow device to obtain flow indices and a frequency-domain tissue-oximeter for optical properties. Flow indices are calculated with measured μa and μs’ or assumed co
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35

Häggblad, Erik. "In vivo diffuse reflectance spectroscopy of human tissue : from point measurements to imaging /." Linköping : Department of Biomedical Engineering, Linköpings universitet, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-15191.

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36

Liang, Bin. "Characterisation of the mucosal immunity in the nasal-associated lymphoid tissue following influenza A virus infection." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271049.

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37

Norrman, Johanna. "Effects of glucocorticoids and colostrum feeding on Gut-associated lymphoid tissue and thymus in neonatal calves /." [S.l.] : [s.n.], 2003. http://www.stub.unibe.ch/html/haupt/datenbanken/diss/bestell.html.

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38

Zedebski, Rosário de Arruda Moura. "Caracterização morfológica, funcional e de ocorrência das tonsilas linguais laterais." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/25/25136/tde-04102007-100956/.

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Propôs-se a caracterização morfológica, funcional e de ocorrência das tonsilas linguais laterais. Compondo o Grupo experimental I, 25 espécimes de línguas humanas foram fixados em solução de formol a dez por cento e assim mantidos até o processamento. Os espécimes foram submetidos à exposição radiográfica para detecção de algum tecido mineralizado. As peças anatômicas foram examinadas a olho nu e com a utilização do estereomicroscópio. Obtiveram-se três blocos de tecido para a análise microscópica de cada espécime: um advindo da tonsila lingual e outros dois das margens laterais da região post
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39

Levy, Blitchtein Saul, Rebata Stefany Plasencia, Domingo Morales Luna, and Valle Mendoza Juana Del. "Coexistence of papillary thyroid microcarcinoma and mucosa-associated lymphoid tissue lymphoma in a context of Hashimoto’s thyroiditis." Elsevier B.V, 2016. http://hdl.handle.net/10757/615646.

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Papillary thyroid cancer (PTC) represents 80%-85% of thyroid cancer and its prevalence has been rising in the last decades. Primary thyroid lymphoma (PTL) accounts for 3% of extranodal lymphomas and about 5% of thyroid malignancies, having a prevalence of one or two cases per million people. Mucosa-Associated Lymphoid Tissue lymphoma represents approximately 30% of PTL. Both entities have an indolent course and a very good prognosis. Diagnosis is made by ultrasound and fine needle aspiration (FNA) or surgery specimen pathology. They have also been associated with HT, but pathogenesis and its l
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40

Guérin, Violaine. "Implication du m. A. L. T. (mucosal associated lymphoid tissue) dans la physiopathologie des dysthyroidies auto-immunes." Nancy 1, 1988. http://www.theses.fr/1988NAN11214.

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41

MERCURIO, VINCENZO. "HIV-1 INFECTED HUMAN LYMPHOID TISSUE REMAINS IMMUNE-ACTIVATED DESPITE ART: SOLUBLE AND EXTRACELLULAR VESICLE-ASSOCIATED CYTOKINES." Doctoral thesis, Università degli Studi di Milano, 2020. http://hdl.handle.net/2434/701595.

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Background In the age of efficient antiretroviral therapy (ART), premature aging (that includes the development of various pathologies) of HIV-1-infected patients with suppressed viral replication becomes an important health problem. These pathologies are associated with residual immune activation after successful ART. Cytokines, which sustain immune activation, can be either in a soluble form or can be associated with extracellular vesicles (EVs). Together with classical soluble cytokines, these EV-associated cytokines may play a key role in HIV-1 infection and pathogenesis. These hypotheses
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42

Quigley, Máire. "Characterisation of CD8 T cells in mucosa associated lymphoid tissue: implications for immune control of HIV-1 infection /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-646-8/.

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43

Doggett, Teresa Ann. "The structure and function of peripheral blood leucocytes and gut-associated lymphoid tissue in the cichlid, Oreochromis mossambicus." Thesis, University of Plymouth, 1989. http://hdl.handle.net/10026.1/2776.

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The peripheral blood of O.mossambicus was examined using light and electron microscopy and was found to contain four forms of leucocytes: lymphocytes, thrombocytes, monocytes and three types of granulocytes. The monocyte and two types of granulocyte were found to be phagocytic and ingest colloidal carbon and bacteria. The alimentary tract was found to contain a number of leucocytes, some showing a morphological similarity to those in the peripheral blood, while others were unique to the gut tissue. These intestinal leucocytes were found mainly as a diffuse cell population in the epithelium and
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Quigley, Máire. "Characterisation of CD8 T cells in mucosa associates lymphoid tissue implications for immune control of HIV-1 infection /." Stockholm : Karolinska Institutet, 2006. http://diss.kib.ki.se/2006/91-7140-646-8/thesis.pdf.

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45

Ti, Yalin. "In Vivo Characterization of Myocardial Tissue Post Myocardial Infarction Using Combined Fluorescence and Diffuse Reflectance Spectroscopy." FIU Digital Commons, 2009. http://digitalcommons.fiu.edu/etd/95.

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Accurately assessing the extent of myocardial tissue injury induced by Myocardial infarction (MI) is critical to the planning and optimization of MI patient management. With this in mind, this study investigated the feasibility of using combined fluorescence and diffuse reflectance spectroscopy to characterize a myocardial infarct at the different stages of its development. An animal study was conducted using twenty male Sprague-Dawley rats with MI. In vivo fluorescence spectra at 337 nm excitation and diffuse reflectance between 400 nm and 900 nm were measured from the heart using a portable
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46

Juleff, Nicholas Dylan. "Interactions of foot-and-mouth disease virus with cells in organised lymphoid tissue influence innate and adaptive immune responses." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4256.

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Foot-and-mouth disease virus (FMDV) is one of the most contagious viruses of animals and is recognised as the most important constraint to international trade in animals and animal products. Two fundamental problems remain to be understood before more effective control measures can be put in place. These problems are the FMDV „carrier state‟ and the short duration of immunity after vaccination which contrasts with prolonged immunity after natural infection. The aim of this thesis was to study the interaction between FDMV and cells in lymphoid tissue in the natural bovine host, in order to impr
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QUIQUANDON, ISABELLE. "Biopsie des glandes salivaires accessoires et lymphomes : syndrome de gougerot sjogren et lymphomes du malt (mucosa associated lymphoid tissue)." Lille 2, 1990. http://www.theses.fr/1990LIL2M360.

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48

Doyle, Chloe. "Investigating The Immunology Of Crohn’s Disease." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/29965.

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Crohn’s disease is a chronic autoimmune disease characterised by chronic inflammation in the gastrointestinal tract caused by an uncontrolled immune reaction to commensal bacteria. It is steadily increasing in incidence across the globe, especially in young adults. Current treatments act to reduce inflammation but there is no cure. This is because this disease is still poorly understood especially regarding the specific immune cells involved. Defining these cells and their functions could provide critical insights into the causes and progression of this disease and pave the way for therapeutic
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Izquierdo-Roman, Alondra. "Localized Mechanical Compression as a Technique for the Modification of Biological Tissue Optical Properties." Thesis, Virginia Tech, 2011. http://hdl.handle.net/10919/76856.

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Tissue optical clearing aims to increase the penetration depth of near-collimated light in biological tissue to enhance optical diagnostic, therapeutic, and cosmetic procedures. Previous studies have shown the effects of chemical optical clearing on tissue optical properties. Drawbacks associated with chemical clearing include the introduction of potentially toxic exogenous chemicals into the tissue, poor site targeting, as well as slow transport of the chemicals through tissue. Thus, alternative clearing methods have been investigated. Mechanical compression is one such alternative tissue opt
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Yadav, Nitin. "In Vivo characterization of Epileptic Tissue with Optical Spectroscopy." FIU Digital Commons, 2012. http://digitalcommons.fiu.edu/etd/728.

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For children with intractable seizures, surgical removal of epileptic foci, if identifiable and feasible, can be an effective way to reduce or eliminate seizures. The success of this type of surgery strongly hinges upon the ability to identify and demarcate those epileptic foci. The ultimate goal of this research project is to develop an effective technology for detection of unique in vivo pathophysiological characteristics of epileptic cortex and, subsequently, to use this technology to guide epilepsy surgery intraoperatively. In this PhD dissertation the feasibility of using optical spectros
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