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Dissertations / Theses on the topic 'The Hedgehog signaling pathway'

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Published: 4 June 2021

Last updated: 4 February 2022

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1

Nedelcu, Daniel. "Smoothened regulation in the Hedgehog signaling pathway." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11080.

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Hedgehog signaling is a pathway essential in embryonic development, adult stem cell maintenance, and is implicated in the formation and progression of cancer. Signaling in this pathway is triggered when the secreted protein Hedgehog binds to its membrane receptor, Patched. Patched normally inhibits the seven-spanner transmembrane protein Smoothened (Smo). Binding of Hedgehog inhibits Patched resulting in Smo derepression. Active Smo then triggers the activation of the cytoplasmic steps of the signaling pathway.

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2

Lopez, Lyle Villamater. "Regulation of Gli proteins by the Hedgehog Signaling Pathway." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11095.

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3

Vila, Greisa. "Sonic hedgehog signaling pathway in normal and adenomatous pituitary." Diss., lmu, 2004. http://nbn-resolving.de/urn:nbn:de:bvb:19-20853.

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4

Tokarew, Nicholas. "The Role of Norrie Disease Pseudoglioma (Ndp) in Cerebellar Development/Tumorigenesis and Its Relationship with the Sonic Hedgehog Pathway." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/36936.

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Medulloblastoma (MB), a cancer of the cerebellum, is the most common solid tumor affecting children. In the cerebellum, Sonic Hedgehog (Shh) drives the proliferative expansion of granule neuron progenitors (GNP). These cells are located in the external granule layer (EGL) and are the cells of origin of Shh-MB. We recently identified Norrie Disease Pseudoglioma (Ndp) as a novel downstream target of Hh signaling in the developing retina. Ndp encodes an X-linked cysteine-rich secreted protein called Norrin, which is best known for its role in angiogenesis and blood brain barrier (BBB) maintenance

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5

Liao, Xiaoyun, and 廖晓耘. "Hedgehog signaling pathway and epigenetic studies in ovarian carcinomas and endometrial carcinomas." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41290367.

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Liao, Xiaoyun. "Hedgehog signaling pathway and epigenetic studies in ovarian carcinomas and endometrial carcinomas." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41290367.

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7

Ringuette, Randy. "The Role of Signaling Pathway Integration in Neurogenesis." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/35108.

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Proper central nervous system development is critical for survival and depends on complex intracellular and extracellular signaling to regulate neural progenitor cell growth and differentiation; however, the mechanisms that mediate molecular crosstalk between pathways during neurogenesis are not fully understood. Here, we explored the integration of the Hedgehog (Hh) signaling pathway with the two critical developmental pathways, Receptor Tyrosine Kinase (RTK) and Notch signaling, in the growth and maintenance of neural progenitors in the developing neuroretina. We found combined and sustain

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8

Gao, Yang, and Yang Gao. "Lithium-Induced Nephropathy: The Role Of mTOR Signaling, Primary Cilia And Hedgehog Pathway." Diss., The University of Arizona, 2014. http://hdl.handle.net/10150/347188.

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Lithium is given to millions of bipolar disorder or post-traumatic disorder patients. The recent studies also support a role for lithium in treating neurodegenerative disease such as Parkinson's disease and stroke. Lithium treatment leads to lithium nephropathy, which includes lithium-induced nephrogenic diabetic insipidus (NDI), lithium-induced renal cell proliferation leading to the formation of microcysts in the kidney, and lithium-induced renal fibrosis. However, there is still a gap in understanding the mechanisms and signaling pathways involved in regulating lithium-induced nephropathy.

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9

Hardcastle, Zoe. "The Sonic Hedgehog signalling pathway in tooth development." Thesis, King's College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368160.

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10

Cheng, Shuofei. "Role of G-protein-coupled receptor kinase 2 in the «Drosophila» Hedgehog Signaling Pathway." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=119539.

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The Hedgehog (Hh) signaling pathway is an essential and highly conserved pathway required for embryonic development and adult tissues homeostasis in both invertebrates and vertebrates. In humans, abnormal Hh signaling leads to numerous congenital diseases and deregulation of Hh signaling is associated with certain aspects of tumorigenesis. Therefore, a complete characterization of this pathway may help us to better understand the role of Hh signaling under physiological and pathological conditions. A key transducer of Hh signaling is Smoothened (Smo), a seven-pass transmembrane protein and dis

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11

McNeill, Brian. "Identification of Sox8 and Ndp as Novel Targets of the Hedgehog Signaling Pathway in the Retina." Thesis, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/22655.

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During embryonic development, the Hedgehog (Hh) signaling pathway plays an important role in the growth and patterning of numerous tissues and organs. In the developing retina, Hh signaling regulates the proliferation and differentiation of retinal progenitor cells (RPC) through mechanisms that are not completely understood. The principal downstream mediators of the Hh pathway are the Gli transcription factors (Gli1-3), which regulate the expression of target genes responsible for the effects of the Hh pathway on RPC. The network of genes targeted by this pathway in neural progenitor cells how

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12

Whalen, Daniel M. "Structural and functional studies of the hedgehog signalling pathway." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:ce0e765c-04f1-4a64-a67b-89204ecaa155.

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Hedgehog (Hh) morphogens play fundamental roles in development whilst dysregulation of Hh signalling leads to disease. Multiple receptors are involved in the modulation of Hh morphogens at the cell surface. Among these, the interactions of Hh ligands with glycosaminoglycan (GAG) (for example heparan or chondroitin sulphate) chains of proteoglycans in the extracellular matrix play a key role in shaping morphogen gradients and fulfil important functions in signal transduction. Several high resolution crystal structures of Sonic Hh (Shh)-GAG complexes have been determined. The interaction determi

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13

Saldanha, Gerald Stephen. "The Hedgehog signalling pathway and its role in cancer." Thesis, University of Leicester, 2001. http://hdl.handle.net/2381/29393.

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Mutations in Hedgehog (Hh) pathway genes such as Patched1 are of established importance in Basal cell carcinoma (BCC). However, BCC is unusual because it has indolent behaviour and rarely metastasises. Hh pathway gene mutations are rare in cancers with more typical malignant behaviour, leading to the hypothesis that the pathway plays an important role in BCC but has limited importance in cancers with typical malignant behaviour. This has been addressed in three ways. First, evidence that superficial BCC is a clonal proliferation driven by alterations at the Patched1 locus was sought. Second, e

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14

Vanderlaan, Gary. "Differential roles for hedgehog signaling in motor neuron development." Diss., Columbia, Mo. : University of Missouri-Columbia, 2006. http://hdl.handle.net/10355/4461.

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Thesis (Ph.D.)--University of Missouri-Columbia, 2006.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on April 29, 2009) Vita. Includes bibliographical references.

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15

Ferreira, Catarina Domingues. "WNT/ß-catenin and Hedgehog signaling pathways as therapeutic targets in B cell neoplasms." Master's thesis, Universidade de Aveiro, 2018. http://hdl.handle.net/10773/22676.

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Mestrado em Bioquímica - Métodos Biomoleculares<br>As neoplasias de células B são caracterizadas por um grupo heterogéneo de doenças que incluem linfomas de células B e doenças de células plasmáticas, entre outras. O mieloma múltiplo (MM) é uma neoplasia maligna originada pela proliferação de células plasmáticas monoclonais que permanece incurável. Esta proliferação de células plasmáticas malignas no microambiente da medula óssea produz proteína monoclonal no sangue ou na urina e está associada a sinais malignos. Representa aproximadamente 1% das doenças neoplásicas e 10% a 15% das neoplasias

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16

Lees, Charles William. "Role of the hedgehog signalling pathway in inflammatory bowel disease." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4233.

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Introduction. The inflammatory bowel diseases (IBD), Crohn’s disease (CD) and ulcerative colitis (UC), are common in Western Europe (200-400 cases /100,000) and associated with substantial morbidity, although mortality is now low. There is presently a great unmet need for novel therapeutics in IBD as present agents are limited by lack of efficacy, toxicity and poor patient acceptance. Recent findings from genome-wide association studies (GWAS) have characterised the genetic architecture of CD and UC. Defects in innate and adaptive immunity have been clearly established, and substantial novel i

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17

Vitellozzi, Lucia. "Studies towards steroidal modulators of the Hedgehog/Gli signalling pathway." Thesis, University of York, 2014. http://etheses.whiterose.ac.uk/7624/.

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The modern age faces a progressive lengthening of life span, which is often associated with the onset of degenerative disorders such as Parkinson’s, Alzheimer’s and cancer. These diseases do not yet have a cure. The Hedgehog/Gli signalling pathway is one of the most promising pathways of cellular communication. Pharmacological modulation of this pathway would provide a remarkable approach for new potential therapeutics in regenerative medicine and cancer. Attention was focussed on coagulin L and withanolide F, two natural steroidal lactones featuring interesting reactive functionalities. The a

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18

Straughton, Debbie. "Molecular analysis of the Sonic Hedgehog signalling pathway in childhood medulloblastoma." Thesis, University of Newcastle Upon Tyne, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.435569.

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19

Patil, Sumersing [Verfasser], Herbert [Akademischer Betreuer] Waldmann, and Leif [Gutachter] Dehmelt. "Discovery of novel targets in the hedgehog signaling pathway / Sumersing Patil ; Gutachter: Leif Dehmelt ; Betreuer: Herbert Waldmann." Dortmund : Universitätsbibliothek Dortmund, 2017. http://d-nb.info/1172970955/34.

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20

Campbell, Victoria L. "Determining the role of the Hedgehog signalling pathway in acute myeloid leukaemia." Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/30656/.

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Acute myeloid leukaemia (AML) encompasses a group of aggressive haematological neoplasms. It is a cancer stem cell (CSC) disorder. The Hedgehog (Hh) signalling pathway is one of the self-renewal pathways, highly conserved across species and important in determining stem cell fate, affecting a number of clinically important downstream targets including the Bcl-2 family. Abnormal Hh signalling has been associated with a diverse range of human malignancies. In myeloid malignancies, Hh signalling has been found to be vital in the maintenance and expansion of the CSC. Primary immotile cilia regulat

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21

Zheng, Chaoqun. "Molecular mechanisms of the anti-cancer action of schweinfurthins." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/1815.

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Schweinfurthins are a family of natural products with significant anti-cancer activities. They were originally identified in the National Cancer Institute (NCI) human 60 cancer cell line screening. The growth inhibition profile of schweinfurthins is distinct from other clinically used anti-cancer agents, indicating that they have a novel mechanism of action or have a previously unrecognized protein target. Previous studies showed that schweinfurthins affect multiple cellular processes in cancer cells. For example, schweinfurthins can alter cytoskeleton organization, induce ER stress and apopto

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22

Yu, Chuan. "Mouse retinal histogenesis in the context of cell autonomous Hedgehog signalling pathway activation." Thesis, University of Ottawa (Canada), 2005. http://hdl.handle.net/10393/27093.

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The adult mouse retina is a laminated assemblage of specialized neurons and glia, which serves as a model system for cell type specification in the CNS (central nervous system). The multiple cell types in the retina are derived from a retinal neuroepithelium, which contains multipotent retinal precursor cells (RPCs) that differentiate into specific retinal cell types. The morphogen Shh is expressed in the retinal ganglion cells (RGCs), and signals to the RPCs located in the overlying neuroblast layer of the developing retina. To distinguish between cell- and non-cell autonomous effects of the

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23

Guo, Daorong. "Dissecting Signaling Pathways that Regulate Axonal Guidance Effects of Sonic Hedgehog: A Dissertation." eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/531.

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During development, axons respond to a variety of guidance cues in the environment to navigate to the proper targets. Sonic hedgehog (Shh), a classical morphogen, has been shown to function as a guidance factor that directly acts on the growth cones of various types of axons. We previously found that Shh affects retinal ganglion cell (RGC) axonal growth and navigation in a concentration-dependent manner. However, the signaling pathways that mediate such events are still unclear. In this thesis, we show that high concentrations of Shh induce growth cone collapse and repulsive turning of the chi

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24

Dhanyamraju, Pavan Kumar [Verfasser], and Matthias [Akademischer Betreuer] Lauth. "Histone deacetylase 6 represents a novel drug target in the oncogenic Hedgehog signaling pathway / Pavan Kumar Dhanyamraju ; Betreuer: Matthias Lauth." Marburg : Philipps-Universität Marburg, 2017. http://d-nb.info/1144626110/34.

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25

Bruzzone, Lucía. "A crosstalk between the RNA binding protein Smaug and the Hedgehog pathway links cell signaling to mRNA regulation in drosophila." Thesis, Sorbonne Paris Cité, 2018. https://theses.md.univ-paris-diderot.fr/BRUZZONE_Lucia_1_va_20180319.pdf.

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La régulation post-transcriptionnelle de l'expression génique joue un rôle essentiel dans divers processus cellulaires pendant le développement. Les protéines de liaison à l'ARN (RBP) sont des médiateurs fondamentaux des régulations post-transcriptionnelles qui contrôlent l'expression de l'ARNm en reconnaissant des séquences spécifiques dans les transcrits cibles. Smaug est une protéine de liaison à l'ARN conservée de la levure jusqu’à l’homme qui est essentielle pendant l'embryogenèse précoce de la drosophile. Smaug reconnaît et lie des éléments de reconnaissance de Smaug (SRE) dans ses ARNm

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26

Kremer, Lea [Verfasser], Herbert [Akademischer Betreuer] Waldmann, and Alfred [Gutachter] Wittinghofer. "Identification and characterization of novel hedgehog signaling pathway inhibitors and their cellular targets / Lea Kremer ; Gutachter: Alfred Wittinghofer ; Betreuer: Herbert Waldmann." Dortmund : Universitätsbibliothek Dortmund, 2018. http://d-nb.info/1160443289/34.

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27

Freeman, Emily. "Crosstalk Between the Planar Cell Polarity and Hedgehog Signaling Pathways Influences Satellite Cell Fate." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/38707.

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Our laboratory has identified two secreted proteins, Wnt7a and Sonic hedgehog (Shh), that regulate satellite cell (SC) fate, during muscle differentiation. While Wnt7a stimulates symmetric SC division through the planar cell polarity (PCP) pathway, Shh activates Myf5 expression in the committed SC following asymmetric division through cilia-mediated Hedgehog (Hh) signaling. Crosstalk between these pathways has been well characterized during development, and is likely to be conserved in muscle regeneration. Indeed, accumulating evidence suggests the PCP pathway influences primary cilia formatio

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Byrne, Eamon. "Molecular mechanisms of Hedgehog signal transduction by the G-protein coupled receptor smoothened." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:38abef20-ae98-4835-919c-73afc21a6252.

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The Hedgehog signalling pathway is an essential developmental pathway present in all bilaterians that is involved in embryogenesis, body patterning and stem cell homeostasis. Dysregulation of the Hh pathway leads to various kinds of cancer, such as basal cell carcinoma and medulloblastoma. Smoothened (SMO), a Frizzled-type G-protein coupled receptor (GPCR), is the essential transmembrane signal transducer within the Hh pathway, conveying the signal from the upstream transmembrane protein, Patched1 (Ptc1), to the downstream intracellular proteins. The mechanisms by which SMO transmits the Hh si

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29

Armstrong, Benjamin. "Investigating the Molecular Signaling Pathways Governing Proliferation, Differentiation, and Patterning During Zebrafish Regenerative Osteogenesis." Thesis, University of Oregon, 2016. http://hdl.handle.net/1794/20433.

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Upon amputation, zebrafish innately regenerate lost or damaged bone by precisely positioning injury-induced, lineage-restricted osteoblast progenitors (pObs). While substantial progress has been made in identifying the cellular and molecular mechanisms underlying this fascinating process, the cell-specific function of these pathways is poorly understood. Understanding how molecular signals initiate osteoblast dedifferentiation, balance progenitor renewal and re-differentiation, and control bone shape during regeneration are of paramount importance for developing human therapies. We show t

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Svärd, Jessica. "Repressing the hedgehog signalling pathway : functional analysis of the tumour suppressors patched1 and suppressor of fused /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-380-1/.

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31

Singh, Rajeev [Verfasser], and Matthias [Akademischer Betreuer] Lauth. "Elucidating the functional role of Dual-specificity Tyrosine Regulated Kinase 1B (DYRK1B) in the Hedgehog (Hh) Signaling Pathway. / Rajeev Singh ; Betreuer: Matthias Lauth." Marburg : Philipps-Universität Marburg, 2018. http://d-nb.info/1166314146/34.

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32

Katagiri, Tomohiro. "HIF-1 maintains a functional relationship between pancreatic cancer cells and stromal fibroblasts by upregulating expression and secretion of Sonic hedgehog." Kyoto University, 2018. http://hdl.handle.net/2433/232470.

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33

Ikram, Mohammed S. "Analysis of Sonic Hedgehog signalling pathway gene expression in Basal Cell Carcinoma and in GLII induced systems." Thesis, Queen Mary, University of London, 2007. http://qmro.qmul.ac.uk/xmlui/handle/123456789/1527.

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Embryonic development is regulated by a number of signalling pathways, which are critical for normal growth. Many of these genes then continue to play an important role in the regulation of cell growth and differentiation in adult. One such pathway is the sonic hedgehog (SHH) pathway; SHH protein is secreted which binds to its receptor patched (PTCH), leading to the activation and repression of target genes via zinc-finger GLI family transcription factors. Deregulation of this pathway, leads to a number of human birth defects and diseases such as Basal Cell Carcinoma (BCC) of the skin. In tran

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34

Ambreen, Munazzah. "Identification of signal transduction pathways mediating the downregulation of Indian hedgehog (Ihh) expression by FGF signaling in chondrocytes." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=100758.

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Activating mutations in the Fibroblast Growth Factor Receptor-3 gene (FGFR3) cause a number of chondrodysplasia in human, including achondroplasia (ACH) the most common form of inherited dwarfism. Mouse models of achondroplasia have shown that one consequence of inappropriate Fgfr3 activation is a significant reduction in the level of expression of the Indian hedgehog gene (Ihh), encoding a signaling peptide essential for growth plate chondrocyte proliferation and maturation. How FGFR3 signaling controls Ihh transcription is unknown.<br>We used specific small molecule inhibitors of some of the

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35

Schramm, Stefanie. "Hinweise auf Reduktion von Steatosis hepatis durch Metformin in vitro." Doctoral thesis, Universitätsbibliothek Leipzig, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-102040.

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Die Arbeit beschäftigt sich mit dem Problem der Fettlebererkrankung. In der Einleitung wird auf die aktuelle Relevanz der Gesundheitsstörung und Therapiemöglichkeiten eingegangen, insbesondere durch das, in der Therapie des Diabetes mellitus Typ 2 gebräuchliche Biguanid Metformin. Der Bezug zu molekularbiologischen Signalwegen wird hergestellt und verschiedene in vitro Modellsysteme werden vorgestellt. Anschließend wird auf die Herkunft und genetische Besonderheiten der verwendeten primären Maushepatozyten und Hepatomzellen eingegangen, bevor die angewandten Methoden vorgestellt werden. Zum Ei

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Geyer, Natalie [Verfasser], Heidi [Akademischer Betreuer] Hahn, Matthias [Gutachter] Dobbelstein, and Dieter [Gutachter] Kube. "Targeting the Hedgehog and PI3K/AKT/mTOR signaling pathways in rhabdomyosarcoma / Natalie Geyer ; Gutachter: Matthias Dobbelstein, Dieter Kube ; Betreuer: Heidi Hahn." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2018. http://d-nb.info/117397489X/34.

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37

Belgacemi, Randa. "CARACTÉRISATION DE LA VOIE HEDGEHOG DANS LA DIFFÉRENCIATION DE L'ÉPITHÉLIUM DES VOIES AÉRIENNES ET ALTÉRATION DANS LA BPCO Airway epithelial cell differentiation relies on deficient Hedgehog signalling in COPD." Thesis, Reims, 2020. http://www.theses.fr/2020REIMS009.

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La voie Hedgehog (HH) est une voie de signalisation cruciale pour l’organogenèse et l’homéostasie. Etant donnée son implication dans la quiescence et la réparation pulmonaire ainsi que son altération dans des maladies respiratoires chroniques, nous avons exploré la présence et l’impact de la voie HH durant la différenciation de l’épithélium des voies aériennes et son incidence sur la genèse du remodelage épithélial caractéristique de la BPCO.Nous avons mis en évidence une corrélation entre l’expression des acteurs de la voie HH et la différenciation in vitro ainsi qu’une sécrétion du ligand pr

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Makamté, Kemdib Staëlle Sonia. "Etudes des protéines Patched et SUFU impliquées dans la voie de signalisation Hedgehog." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCC102/document.

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Parmi les voies de signalisation, la voie hedgehog (HH) intervient dans la formation de la polarité segmentaire. Si elle est défectueuse, elle entraine plusieurs malformations. De nombreux cancers présentent une suractivation de cette voie. La voie HH activée par la fixation du ligand HH sur le récepteur Patched (hPtc) et fait intervenir plusieurs partenaires cytoplasmiques dont Supressor of Fused (SUFU).Peu de données moléculaires et structurales sont disponibles pour cette voie et pourtant, ces données sont nécessaires pour comprendre sans ambiguïté son fonctionnement. De plus, la voie HH a

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Cadavid, Ana Maria Hoyos. "Avaliação imunoistoquímica das proteínas da via de sinalização Sonic Hedgehog (Shh, Ptch1, Ptch2, Smo, Gli1, Gli2 e Gli3) em tumores odontogênicos queratocísticos associados ou não à Síndrome do Carcinoma Basocelular Nevoide." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/23/23141/tde-03112016-193935/.

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O Tumor Odontogênico Queratocístico (TOQC) é considerado uma entidade com alta taxa de recidiva e agressividade local, apresentando também frequente associação com a Síndrome do Carcinoma Basocelular Neviode (SCBCN), por isso a patogêneses de este tumor tem sido intensamente estudada. A transformação e proliferação de células neoplásicas normalmente envolvem a desregulação de vias de sinalização que participam do desenvolvimento embrionário normal, principalmente a via Sonic Hedgehog (Shh). A expressão de certas proteínas presentes nesta via foi detectada em vários tumores odontogênicos, suger

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Linder, Benedikt [Verfasser], Heidi [Akademischer Betreuer] Hahn, and Matthias [Akademischer Betreuer] Dobbelstein. "Interaction of the Hedgehog and vitamin D receptor signaling pathways in Patched associated cancers / Benedikt Linder. Gutachter: Heidi Hahn ; Matthias Dobbelstein. Betreuer: Heidi Hahn." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2015. http://d-nb.info/1070996173/34.

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Port, Rebecca. "Epstein-Barr virus induction of the hedgehog signalling pathway imposes a stem cell-like phenotype on human epithelial cells : implications for the pathogenesis of nasopharyngeal carcinoma." Thesis, University of Birmingham, 2014. http://etheses.bham.ac.uk//id/eprint/5013/.

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Nasopharyngeal carcinoma (NPC) is endemic in Southern China and South East Asia, causally linked to Epstein-Barr virus (EBV) infection, and frequently shows dysregulation in a number of stem cell maintenance signalling pathways. This thesis has endeavoured to investigate the status of one of these pathways; the Hedgehog (HH) signalling pathway, in NPC tumours, and reveals the novel finding that EBV is able to active the HH signalling pathway through autocrine induction of the SHH ligand in the C666.1 authentic EBV-positive NPC-derived cell line and latently infected epithelial carcinoma cell l

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42

Patel, Sagar. "THE MECHANOTRANSDUCTION OF PRIMARY CILIA IN TUMOR PROGRESSION OF LUNG ADENOCARCINOMA." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/3071.

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The objective of this study was to investigate primary cilia and their mechanotransduction role in lung adenocarcinoma tumor progression. The main focus investigated the effect of primary cilia on cell cycle progression, survival, adhesion and migration analysis of these cells and the role of sonic hedgehog signaling pathway in mechanotransduction. Human Non-Small Cell Lung Cancer (NSCLC) adenocarcinoma biopsies contain more primary cilia than non-tumor lung sections. To observe the effects of primary cilia presence in lung cancer cells in-vitro, formation of primary cilia is inhibited using

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Bal, Élodie. "Les voies Hedgehog et NF-κB au coeur de l'homéostasie cutanée : apport de la caractérisation génétique et physiopathologique de deux dysplasies ectodermiques liées à l'X, le syndrome de Bazex-Dupré-Christol et l'Incontinentia Pigmenti". Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCB116/document.

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Les genodermatoses sont des maladies génétiques rares à expression cutanée. Parmi elles, les dysplasies ectodermiques (DE) caractérisées par des anomalies du développement d’au moins deux structures ectodermiques (dents, ongles, glandes sudorales et poils), constituent un groupe hétérogène de genodermatoses de plus de 200 syndromes rares. Si la plupart de ces syndromes associent des anomalies des seuls dérivés ectodermiques, d'autres plus complexes, tels que le syndrome de Bazex-Dupré-Christol et l’Incontinentia Pigmenti, rassemblent en plus des manifestations disparates. Le syndrome de Bazex-

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44

Lau, Janet. "Hedgehog signaling in the pancreas epithelium." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2010. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3398879.

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Koziel, Lydia. "Indian hedgehog signaling during endochondral ossification." [S.l. : s.n.], 2004. http://www.diss.fu-berlin.de/2005/68/index.html.

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Tukachinsky, Hanna. "Mechanistic Studies of Vertebrate Hedgehog Signaling." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10691.

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Metazoans use Hedgehog signaling to direct many stages of embryonic development, and deregulation of this pathway is implicated in many types of cancer. I investigated several steps of Hedgehog pathway transduction that were poorly understood in mechanistic terms. The mature Hedgehog ligand is produced by a self-proteolysis reaction that covalently attaches a cholesterol molecule to the signaling half of the protein. I showed that the catalytic cysteine forms a disulfide bridge that is essential for the folding and function of the C-terminal tail of Hedgehog, and identified two protein disulfi

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Wilson, Christopher William. "Mechanism and evolution of mammalian hedgehog signaling." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3378515.

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Hsieh, David. "Hedgehog signaling in glioblastoma multiforme stem cells." Thesis, The University of Arizona, 2009. http://hdl.handle.net/10150/192485.

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Steg, Adam. "Analysis of the hedgehog pathway in pancreatic adenocarinoma." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2008d/steg.pdf.

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Boylan, Arianne J. "CCM2 molecular signaling pathway." [New Haven, Conn. : s.n.], 2007. http://ymtdl.med.yale.edu/theses/available/etd-08062007-135532/.

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