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Dissertations / Theses on the topic 'The history of Cancer'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Cunningham, David. "Gastric cancer : natural history and treatment." Thesis, University of Glasgow, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293449.

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2

Andrén, Ove. "Natural history and prognostic factors in localized prostate cancer." Doctoral thesis, Örebro University, Academy of Health Science, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-2109.

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<p>The natural history of localized prostate cancer is not fully understood. In most patients the tumor will never progress to a lethal disease, while a subset of patients will ultimately die of the disease. Efficient tools to separate indolent from lethal disease is currently lacking which means that many patients will be offered treatment without any benefit, but still be at risk of experiencing treatment related side effects.</p><p>The aims of these studies were to get more insight into the natural history of untreated localized prostate cancer, to assess the prognostic value of established

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3

Andrén, Ove. "Natural history and prognostic factors in localized prostate cancer /." Örebro : Örebro University, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-2109.

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4

Yeung, Yuk-pang, and 楊玉鵬. "Natural history of untreated hepatocellular carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31972287.

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5

Sridhar, Gayathri. "Meta-analysis: Racial Disparities in Prostate Cancer Survival and Case-Control Study: Association between Family History of Cancers, Obesity and Prostate Cancer." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1758.

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This is a compilation of 3 abstracts for the three manuscripts included in this dissertation. I. Meta-Analysis: Racial Disparities in Prostate Cancer Survival: Prostate cancer is the second leading cause of cancer-related mortality in men. Previous studies have drawn inconsistent conclusions on racial differences in prostate cancer survival. This meta-analysis was conducted to investigate the relationship between race and survival from prostate cancer. A systematic review of published articles from 1968 to 2007 assessing survival from prostate cancer among African American and White men was co

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6

Pashayan, Nora. "The natural history of prostate cancer in the preclinical phase." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609461.

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7

Margolin, Sara. "Family history and breast cancer susceptibility : clinical and molecular studies /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-868-1/.

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8

Garcia, Mary Carmen. "Data Summary: Significance of Family History in Breast Cancer Diagnosis." Thesis, The University of Arizona, 2010. http://hdl.handle.net/10150/146566.

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Background: Family history and its significance in Hispanic breast cancer cases with a known BRCA mutation has not been widely studied. Methods: Family history, BRCA mutation and age data were obtained for a subset of 91 individuals derived from the ELLA Binational Breast Cancer Study population, in order to determine the importance of family history in the context of BRCA mutation status. Results: A total of 8 different BRCA1 and BRCA2 mutations were found within the study population. Only 11 of the 91 participants (12.1%) were found to possess a BRCA mutation. Of these 11 women, 6 (54.5%) ha

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9

Nguyen, Bastien. "Impact of reproductive history and pregnancy on breast cancer biology." Doctoral thesis, Universite Libre de Bruxelles, 2018. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/278388.

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It is estimated that four in five women will give birth while one in eight women will be diagnosed with breast cancer at some point in her lifetime. It is also known that pregnancy at a young age is associated with a marked decrease in the risk of breast cancer and that this protection is different according to breast cancer subtypes. This thesis explores the impact of reproductive history on breast cancer biology and provides the molecular characterization of breast cancer diagnosed during pregnancy. The last part investigates the effect of RANKL inhibition on the biology of breast cancer in

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10

Collier, Ashley. "Integration of family health history in clinical guidelines for breast, ovarian, and colorectal cancer." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1337350837.

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11

McDowell, Michelle Elizabeth. "The Weight of History: Does Family History Influence Men's Perceptions of Risk and Prostate Cancer Screening Decisions." Thesis, Griffith University, 2011. http://hdl.handle.net/10072/366074.

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The benefits of early detection screening for prostate cancer are still unclear and current screening guidelines recommend that men make an informed, personal decision based on an understanding of the risks, benefits, and uncertainties associated with screening. Men with a first-degree family history of prostate cancer are at more than double the risk of being diagnosed with prostate cancer than are men without a family history. However, contrary to predictions put forward in previous research, although men with a family history of prostate cancer report greater risk perceptions and prostate c

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12

Turati, F. "FAMILY HISTORY OF CANCER AND FAMILY HISTORY SCORES FOR ASSESSING THE LEVEL OF DISEASE RISK IN FAMILIES." Doctoral thesis, Università degli Studi di Milano, 2013. http://hdl.handle.net/2434/215073.

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In the last decades genetic factors are playing an increasingly important role in medical research, given the evidence for the existence of a heritable susceptibility for various diseases, including common cancers, based on reports of families with multiple affected relatives. Epidemiologists have utilized family history, usually of first-degree relatives, as a surrogate for genetic risk, aware that family history reflects the consequences of genetic susceptibilities, shared environment, and common behaviors. During my PhD I have dealt with two different aspects of family history, i.e., the

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13

Waserman, Lori. "Before pink ribbons, understanding the invisibility of breast cancer in the Canadian women's health movement during the 1970s and the 1980s." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ26946.pdf.

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14

Fishel, Ben Kenan Rotem. "An Independent Study in the History of Medicine on Lung Cancer." The University of Arizona, 2018. http://hdl.handle.net/10150/626586.

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15

Cetnarskyj, Roseanne. "A study of family history, deprivation and comorbidity in colorectal cancer." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/30437.

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A prospective study of 1540 colorectal cancer cases aged 16-79, diagnosed in Scotland between 3<sup>rd</sup> January 2002 and 31<sup>st</sup> December 2003, was conducted. The main aims are: report the number and proportion of cases that perceive they have a family history risk of colorectal cancer; compare waiting time with symptoms and behaviour after development of symptoms, between cases that perceive a family history risk and do not perceive a family history risk; report the number and proportion of cases in this cohort with a family history of colorectal cancer that meet Scottish clinica

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16

Bergqvist, Oscar. "Calibration of Breast Cancer Natural History Models Using Approximate Bayesian Computation." Thesis, KTH, Matematisk statistik, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-273605.

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Natural history models for breast cancer describe the unobservable disease progression. These models can either be fitted using likelihood-based estimation to data on individual tumour characteristics, or calibrated to fit statistics at a population level. Likelihood-based inference using individual level data has the advantage of ensuring model parameter identifiability. However, the likelihood function can be computationally heavy to evaluate or even intractable. In this thesis likelihood-free estimation using Approximate Bayesian Computation (ABC) will be explored. The main objective is to

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17

McCarthy, Alexandra Leigh. "A rebellious distemper : a Foucaultian history of breast cancer to 1900." Thesis, Queensland University of Technology, 2005. https://eprints.qut.edu.au/16030/1/Alexandra_McCarthy_Thesis.pdf.

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This dissertation explores some of the conditions of possibility underpinning contemporary breast cancer discourse, which is imbued with harsh moral, social and spiritual nuance. I have therefore explored a set of questions concerned with the past state of things in breast cancer care that laid the foundation for present approaches. I wanted to know how it became possible to speak what we now regard as the only truth about breast cancer. I wanted to understand how this truth was determined; who determined it, and who or what gave them the right to assert that their truth was the only truth. I

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18

McCarthy, Alexandra Leigh. "A Rebellious Distemper: A Foucaultian History of Breast Cancer to 1900." Queensland University of Technology, 2005. http://eprints.qut.edu.au/16030/.

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This dissertation explores some of the conditions of possibility underpinning contemporary breast cancer discourse, which is imbued with harsh moral, social and spiritual nuance. I have therefore explored a set of questions concerned with the past state of things in breast cancer care that laid the foundation for present approaches. I wanted to know how it became possible to speak what we now regard as the only truth about breast cancer. I wanted to understand how this truth was determined; who determined it, and who or what gave them the right to assert that their truth was the only truth. I

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19

Reilly, Gretchen A. "Commies, Cancer, and Cavities: The Conflict Over Fluoridation." W&M ScholarWorks, 1992. https://scholarworks.wm.edu/etd/1539625762.

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20

Fichtinger, Andreas. "Factors affecting cancer screening uptake among people with a family history of colorectal cancer : a cross-national perspective." Thesis, University of Sussex, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.441634.

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21

Hernandez-Boussard, Tina Maxine. "P53 mutations as a tool to study the natural history of cancer." Lyon 1, 1999. http://www.theses.fr/1999LYO1T090.

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22

Jonah, Leigh. "The Clinical Validity of Family History in Risk Classification of Colorectal Cancer." Thesis, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31152.

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Objective: To determine the clinical validity of family history (FH) in colorectal cancer (CRC) risk classification. Methods: The Assessment of Risk of Colon Tumors In Canada case-control dataset was used to develop regression models associating risk factors with CRC in Ontario adults. Two regression models (‘clinically-driven’ based on a previously published tool, and data-driven) examined discrimination between CRC cases and controls, with and without the inclusion of FH as a risk variable. Discrimination was assessed using the area under the receiver operator characteristics curve. Results:

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23

Rodríguez, Vivian M. "The Role of Family Organization in Family Health History Communication about Cancer." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/3201.

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Family health history (FHH) has been recognized as an important tool in cancer prevention and health promotion. To date, literature on FHH discussions about cancer have largely focused on patient-physician communication or the dissemination of cancer-specific genetic tests results within the family. Fewer studies have sought to identify family factors that may promote FHH discussions, yet this type of information could be used to identify families needing support in having these conversations. Thus, the present study examined relations between family organization (cohesion and flexibility), co

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24

Yost, Kathleen. "Quality of life in women with a recent history of breast cancer /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2001. http://uclibs.org/PID/11984.

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Thesis (Ph.D.)--University of California, Davis, 2002.<br>Degree granted in Epidemiology. Dissertation completed in 2001; degree granted in 2002. Also available via the World Wide Web. (Restricted to UC campuses)

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25

Wolstenholme, Jane. "Counting the costs of cancer care : breast, cervical and lung cancer in Trent." Thesis, University of Nottingham, 2001. http://eprints.nottingham.ac.uk/12097/.

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The purpose of this thesis is to explore the theory, practice and application of costing with specific reference to cancer. In part it reviews the theory and guidelines related to costing methods including the recent focus on the analytical techniques used with cost data. In addition it examines how these theories and guidelines are applied in practice, by reviewing the literature on costs and cancer. The empirical research in this thesis applies costing methods to three specific cancer sites; breast, cervix and lung. This analysis provides information on the total burden of these specified ca

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26

Murphy, Caroline Claire Scanlon. "A history of radiotherapy to 1950 : cancer and radiotherapy in Britain 1850-1950." Thesis, University of Manchester, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278710.

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27

Abdollahian, Mehrnaz. "Estimating Likelihood of Having a BRCA Gene Mutation Based on Family History of Cancers and Recommending Optimized Cancer Preventive Actions." Scholar Commons, 2015. http://scholarcommons.usf.edu/etd/5893.

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BRCA1 and BRCA2 are gene mutations that drastically increase chances of developing breast and ovarian cancers, up to 20-fold, for women. A genetic blood test is used to detect BRCA mutations. Though these mutations occur in one of every 400 in the general population (excluding Ashkenazi Jewish ethnicity), they are present in most cases of hereditary breast and ovarian cancer patients. Hence, it is common practice for the physicians to require genetic testing for those that fit the rules as recommended by the National Cancer Comprehensive Network. However, data from the Myriad Laboratory, the o

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28

Kresak, Adam M. "The Technological History of Immunohistochemical Methods and Applications in Clinical Cancer Diagnosis and Research." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1531755545522738.

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29

Tomson, Derek. "Evaluating the association between adult primary brain tumours and a family history of cancer." Thesis, University of Ottawa (Canada), 2006. http://hdl.handle.net/10393/27301.

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There are very few established causes of primary brain tumours in adults. Associated with short survival times, increasing effort is being put forth in an attempt to better understand the risk factors of these neoplasms, including investigating the possible relationship with a family history of cancer and germline genetic polymorphisms. This thesis was conducted to evaluate both of these potential associations. Using an international population-based case-control study, the self-reported family histories of cancer were compared between 1089 glioma cases and 1922 matched controls and between 30

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30

Bajdik, Christopher Douglas. "Family history of breast/ovarian cancer and referral criteria for a BRCA1 testing program." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ61058.pdf.

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31

Couto, Elisabeth. "Investigation of the relationship between breast cancer and a family history of the disease." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439151.

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32

Potter, Jeannette Dawn Francesca. "The natural history of neuropathic pain amongst patients with diabetes and patients with cancer." Thesis, King's College London (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415558.

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33

Wu, Samantha. "Characteristics of Cancer Survivors and Women With No Cancer History in the Nurses' Health Study: Prevalence of Risk Factors for Cognitive Decline." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17295892.

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Purpose: There is increased interest in the impact of cancer and cancer treatment on health in aging. Cognitive function has been a focus of such research, however, inadequate understanding of the underlying risk profile, or prevalence of risk factors for cognitive decline across different groups of cancer survivors or persons without cancer limits interpretation of these studies. Methods: Utilizing Nurses’ Health Study questionnaires, we compared lifestyle and health characteristics which are considered primary risk factors for cognitive decline among 6,159 breast, 876 colorectal, and 602 ute

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34

Naicker, Sundresan. "Evaluating Familial History as a Phenotypic Screening Tool for Colorectal Cancer in the Australian General Practice Population." Thesis, University of Sydney, 2016. http://hdl.handle.net/2123/16868.

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Colorectal cancer (CRC) is the second most common cancer among males and third among females across the world. In Australia it is the second most prevalent and the second leading cause of cancer-related mortality with the number of CRC incidences doubling over the last decade. While there has been a reduction of the incidence-adjusted mortality of CRC, a significant number of CRC detections are made at either the intermediate or later stages of the disease progression despite the roll out of a population based screening program for individuals aged 50 and over. Data shows that ‘one size fits a

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35

Nair, Rasmi Girijavallabhan. "Prostate Cancer in High-Risk Population." Diss., Temple University Libraries, 2018. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/515699.

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Epidemiology<br>Ph.D.<br>In 2018, the United States Preventive Services Task Force (USPSTF) recommended that African American men and those with a family history of prostate cancer should discuss the pros and cons of PSA testing with their physician and engage in shared decision making. Identifying risk factors of prostate cancer, calculating individualized prediction of the risk of prostate cancer, and ensuring that the patients are well informed with knowledge to understand these risks so as to easily make decisions, are extremely important in shared decision making. The overarching goal of

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36

Mozhi, Dimple Aneka. "Relationship of dietary antioxidant intake, antioxidant serum capacity, physical activity and inflammation in breast cancer survivors and individuals without a history of cancer." Thesis, Virginia Tech, 2018. http://hdl.handle.net/10919/83842.

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Background: Dietary and serum antioxidants and physical activity can effect inflammation, which is associated with breast cancer risk and recurrence. This study investigated the relationship between diet, serum antioxidant capacity, physical activity, and inflammation in breast cancer survivors and individuals without cancer. Methods: Existing demographic, dietary intake, and physical activity data of 78 breast cancer survivors and 30 individuals without cancer from the Day and Night Study conducted at Virginia Commonwealth University were used. Participants were recruited from southern V

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37

el, zoghbi maysaa. "PROTECTION FROM COLORECTAL CANCERFOLLOWING NEGATIVE COLONOSCOPY IN PATIENTSWITH FAMILY HISTORY OF COLORECTAL CANCER: ASYSTEMATIC REVIEW." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1443205466.

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38

Spadazzi, Chiara <1991&gt. "Modeling the natural history of bone metastasis from breast cancer in a 3D biomimetic scaffold." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2021. http://amsdottorato.unibo.it/10005/1/Tesi%20Spadazzi%20C.pdf.

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The study of bone metastasis from breast carcinoma is hampered by the lack of in vitro models that recapitulate the complex sequential stages and interactions between tumor cells and microenvironment. Animal models could be useful for evaluating the complexity of the bone metastasis process, but this model suffers of being time-consuming and labor intensive. To date, there is no ideal animal model able to replicate different aspects of the metastasis, such as the pre-metastatic niche formation in the host secondary organ. Hence, it emerges the need to fill the gap between in vitro and in vivo

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39

Martin, Thomas Peter Cutlack. "The natural history and management of vestibular schwannomas." Thesis, University of Birmingham, 2012. http://etheses.bham.ac.uk//id/eprint/3748/.

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Over the past decade (2000-), the management of vestibular schwannomas has been in a state of flux. An increasing availability of magnetic resonance imaging has allowed clinicians to monitor tumour progression and increasingly, it has become recognised that once diagnosed, a significant proportion of lesions do not continue to grow. As a result, a number of neurotological centres have advocated conservative management as appropriate for small-medium sized tumours. Birmingham has been one of these centres, and this thesis presents data gathered over the past fifteen years that reflects this cha

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40

Yeung, Pok, and 楊博. "Profile of pre-s deletions in the natural history of chronic hepatitisB and hepatocellular carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44049559.

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41

Djordjevic, Darja. "The Cancer War(d): Onco-Nationhood in Post-Traumatic Rwanda." Thesis, Harvard University, 2016. http://nrs.harvard.edu/urn-3:HUL.InstRepos:33493385.

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In Africa, the effects of the HIV/AIDS pandemic, rapidly expanding industrial and extractive economies, uncontrolled economic growth, environmental and lifestyle changes, and the rising age of populations with better access to medicine have occasioned rising rates of cancer. Rwanda’s national cancer program has been hailed as a unique example of how to build clinical oncology into a public healthcare infrastructure. Using ethnographic data, interviews, and historical archives, I address three sets of questions: 1. What historical, economic, social, and political factors have shaped the develop

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42

Azzarello, Lora M. "Psychological Factors Associated with Skin Cancer Detection Behaviors in Individuals with a Family History of Melanoma." [Tampa, Fla.] : University of South Florida, 2003. http://purl.fcla.edu/fcla/etd/SFE0000174.

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43

Biddulph, Jane Pamela. "Mathematical models of the natural history of colon and rectal adenocarcinoma and their use to predict the effect of different screening strategies." Thesis, Institute of Cancer Research (University Of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286668.

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44

Benjamin, Caroline Mary. "'Realisation of risk' : a central process involved in initiating referral from primary care to cancer services of women with a family history of breast cancer." Thesis, University of Liverpool, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272588.

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45

Viana, Danilo Vilela 1975. "Historia familial de cancer nos pacientes com diagnostico de cancer de colon e reto no Hospital de Clinicas da Unicamp." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309743.

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Orientador: Iscia Teresinha Lopes-Cendes, Carmen Passos Lima<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-06T07:38:24Z (GMT). No. of bitstreams: 1 Viana_DaniloVilela_M.pdf: 17449794 bytes, checksum: 5628cf41f1e3b3dae3d2ad85bb64f5d4 (MD5) Previous issue date: 2006<br>Resumo: O câncer de cólon e reto é a quinta causa de mortalidade por câncer no Brasil. Sua taxa de mortalidade vem apresentando um aumento contínuo desde 1979. Entre os fatores de risco mais importantes para essa doença está a história familial

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46

Naicker, Sundresan. "Evaluating Familial History as a Phenotypic Screening Tool for Colorectal Cancer in the Australian General Practice Population." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/16868.

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Colorectal cancer (CRC) is the second most common cancer among males and third among females across the world. In Australia it is the second most prevalent and the second leading cause of cancer-related mortality with the number of CRC incidences doubling over the last decade. While there has been a reduction of the incidence-adjusted mortality of CRC, a significant number of CRC detections are made at either the intermediate or later stages of the disease progression despite the roll out of a population based screening program for individuals aged 50 and over. Data shows that ‘one size fits a

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47

Smyth, Elizabeth H. "Establishment and evaluation of a new clinical service for women with a family history of breast cancer." Thesis, University of Edinburgh, 2004. http://hdl.handle.net/1842/27432.

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In 1992, a new clinical service for women with a family history was established in Edinburgh. This runs a multidisciplinary clinic with surgeons, geneticists, breast screening radiologists, nurses and a psychologist. The service was one of the first of its kind to be set up in the UK. The introduction outlines the need for such a service, the evidence for breast screening, an outline of the knowledge of breast cancer genetics at the time at which the service was established and previous studies of health-related behaviours of women at increased risk of breast cancer because of a family history

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48

Keane, Michael. "Computational genomic analyses of long-lived mammals to study variation in cancer resistance, longevity and life history." Thesis, University of Liverpool, 2018. http://livrepository.liverpool.ac.uk/3023853/.

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Little is known about the genetic and molecular mechanisms responsible for the great differences in mammalian longevity and life history. One potential source of novel insights is based on comparative analyses of the genomes of species which exhibit extreme longevity and an extended life history. As such, this work describes the results obtained from the analysis of the bowhead whale, naked mole rat (NMR) and human genomes, each of which are exceptionally long-lived compared to closelyrelated species. The bowhead whale genome was analysed with a focus on identifying genes with evidence of posi

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49

Pinto, Pereira Snehal Maureen. "Longitudinal study of mammographic breast density in British women natural history and relationship with breast cancer risk." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.536874.

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50

Emery, Jonathan D. "The development and evaluation of computer support for cancer genetic advice in primary care." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342588.

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