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Journal articles on the topic 'The Ho-Lee model'

Author: Grafiati
Published: 24 April 2022
Last updated: 30 July 2025

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1

Ho, Thomas S. Y., and Sang Bin Lee. "Generalized Ho-Lee Model." Journal of Fixed Income 17, no. 3 (2007): 18–37. http://dx.doi.org/10.3905/jfi.2007.700217.

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2

Ivanov, Roman V. "On the Generalized Inverse Gaussian Volatility in the Continuous Ho–Lee Model." Computation 13, no. 4 (2025): 100. https://doi.org/10.3390/computation13040100.

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This paper presents a new model of the term structure of interest rates that is based on the continuous Ho–Lee one. In this model, we suggest that the drift and volatility coefficients depend additionally on a generalized inverse Gaussian (GIG) distribution. Analytical expressions for the bond price and its moments are found in the new GIG continuous Ho–Lee model. Also, we compute in this model the prices of European call and put options written on bond. The obtained formulas are determined by the values of the Humbert confluent hypergeometric function of two variables. A numerical experiment
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3

Kim, Young Shin, Stoyan V. Stoyanov, Svetlozar T. Rachev, and Frank J. Fabozzi. "Another Look at the Ho–Lee Bond Option Pricing Model." Journal of Derivatives 25, no. 4 (2018): 48–53. http://dx.doi.org/10.3905/jod.2018.25.4.048.

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4

Ebina, Aki, Natsumi Ochiai, and Masamitsu Ohnishi. "Valuation of Game Swaptions under the Generalized Ho-Lee Model." Journal of Mathematical Finance 06, no. 05 (2016): 1002–16. http://dx.doi.org/10.4236/jmf.2016.65065.

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5

Nechaev, M. L. "On the Mean-Variance Hedging in the Ho--Lee Diffusion Model." Theory of Probability & Its Applications 44, no. 1 (2000): 102–6. http://dx.doi.org/10.1137/s0040585x97977380.

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6

Artamonova, Jelena, and Remigijus Leipus. "Obligacijų rinkos modeliavimas trinominio medžio pagalba." Lietuvos matematikos rinkinys 44 (December 17, 2004): 597–602. http://dx.doi.org/10.15388/lmr.2004.32096.

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In this paper a generalization of the discrete-time Ho–Lee model to the trinomial case is considered. The necessary and sufficient conditions for such a bond model to be arbitrage-free and path independent are established.
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7

Sari, Yunita. "Multimodalitas dalam Gambar Iklan Luwak White Koffie Versi Lee Min-Ho”." Metalingua: Jurnal Penelitian Bahasa 15, no. 2 (2018): 235. http://dx.doi.org/10.26499/metalingua.v15i2.73.

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The background of this research is a phenomenon about Indonesia coffee advertisementusing a well-known South Korean actor as its brand ambassador. The problemof this study is how multimodality in Luwak White Koffie Lee Min-Ho version advertisementposter is presented on their official Facebook page during 2016. Thepurpose of this paper is to analyze the hidden meaning within such advertisementposted on their official Facebook page during 2016 as a main source, using qualitativemethod and Kress and van Leeuwen’s social semiotics theories about multimodalitywith three metafunctions, namely repres
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8

Grant, Dwight, and Gautam Vora. "Analytical implementation of the Ho and Lee model for the short interest rate." Global Finance Journal 14, no. 1 (2003): 19–47. http://dx.doi.org/10.1016/s1044-0283(03)00003-6.

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9

Abaffy, Jozsef, Marida Bertocchi, and Adriana Gnudi. "Extensions of the Ho and Lee interest-rate model to the multinomial case." European Journal of Operational Research 163, no. 1 (2005): 154–69. http://dx.doi.org/10.1016/j.ejor.2004.01.005.

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10

Flesaker, Bjorn. "Testing the Heath-Jarrow-Morton/Ho-Lee Model of Interest Rate Contingent Claims Pricing." Journal of Financial and Quantitative Analysis 28, no. 4 (1993): 483. http://dx.doi.org/10.2307/2331161.

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11

Lee, Junho, Daehwan Lee, Kiwon Lee, et al. "Abstract 7430: Multicenter study on an artificial intelligence model for predicting NSCLC recurrence." Cancer Research 85, no. 8_Supplement_1 (2025): 7430. https://doi.org/10.1158/1538-7445.am2025-7430.

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Abstract Background: Accurate and practical prediction of recurrence in early-stage NSCLC is essential for managing patient outcomes and tailoring personalized treatment strategies. This study updated and validated a previously developed transformer-based model for NSCLC recurrence prediction, which integrates clinical, pathological, laboratory, and radiologic data, while proposing strategies to enhance its generalizability. Methods: The model was developed and internally validated using data from Samsung Medical Center (SMC) and Kyung Hee University Hospital (KH) collected from 2008 to 2024.
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12

Ochiai, Natsumi, and Masamitsu Ohnishi. "Valuation of Game Option Bonds under the Generalized Ho-Lee Model: A Stochastic Game Approach." Journal of Mathematical Finance 05, no. 04 (2015): 412–22. http://dx.doi.org/10.4236/jmf.2015.54035.

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13

Izgi, Burhaneddin, and Ahmet Bakkaloglu. "Fundamental solution of bond pricing in the Ho-Lee stochastic interest rate model under the invariant criteria." New Trends in Mathematical Science 1, no. 5 (2017): 196–203. http://dx.doi.org/10.20852/ntmsci.2017.138.

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14

Wilhelm, Jochen. "A fresh view on the Ho-Lee model of the term structure from a stochastic discounting perspective." OR Spectrum 21, no. 1-2 (1999): 9–34. http://dx.doi.org/10.1007/s002910050078.

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15

Kim, Joseph, Jai-Hee Moon, Kyung-Mi Lee, et al. "Abstract 6219: WM-S1, the novel small molecule inhibitor of mutant RTK/receptor tyrosine kinase, for the treatment of cancer." Cancer Research 82, no. 12_Supplement (2022): 6219. http://dx.doi.org/10.1158/1538-7445.am2022-6219.

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Abstract As the representative targeted anticancer drug for colon cancer patients, cetuximab is the EGFR targeted therapeutic antibody and used for treatment of KRAS wild type cancers. Even some patient with KRAS wt gene did not respond cetuximab. However, there is no treatment available for cetuximab-resistant patient group, which is almost 50% of KRAS WT gene holders. Recently, our team identified cetuximab primary resistant related proteins named as mtRTK (mutant receptor tyrosine kinase) by array analysis based cetuximab responder or non-responder colon cancer patient tissues. We investiga
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16

Pyo, Kyoung-Ho, Dong Kwon Kim, Se-Woong Oh, et al. "Abstract 5481: Combination therapy with anti-PD-1 and YH29407, a novel IDO1 inhibitor, enhances T cell-mediated antitumor immunity in MC38 tumor-bearing mice." Cancer Research 82, no. 12_Supplement (2022): 5481. http://dx.doi.org/10.1158/1538-7445.am2022-5481.

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Abstract Background: The IDO is an enzyme responsible for catabolizing tryptophan (Trp) to kynurenine (Kyn). The kynurenine exert important immunosuppressive functions by activating Treg cells and myeloid-derived suppressor cells. YH29407 is a novel IDO1 inhibitor, improved the pharmacodynamics compared to previous IDO inhibitors. Methods: To evaluate antitumor effects and immune profiles of YH29407, YH29407 was dosed at 50 or 100 mg/kg twice daily (B.I.D.) alone or in combination with anti-PD-1 (10 mg/kg, B.I.W., i.p.) and BMS-986205 was dosed at 125 mg/kg once daily (Q.D.) alone or in combin
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17

Baek, Sun Kyung, Jae-Ho Jeong, Yeon-Hee Park, et al. "Abstract P1-18-32: A nationwide real-world study for evaluation of efficacy and safety of T-DM1 in patients with HER2-positive locally-advanced unresectable or metastatic breast cancer in Korea (KCSG BR19-15)." Cancer Research 82, no. 4_Supplement (2022): P1–18–32—P1–18–32. http://dx.doi.org/10.1158/1538-7445.sabcs21-p1-18-32.

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Abstract Purpose: T-DM1, an antibody-drug conjugate, has significant antitumor activity in patients with HER2-positive metastatic breast cancer (mBC) patients who had progressed after trastuzumab-based chemotherapy. This study was conducted to investigate the clinical practice and factors related with outcomes of T-DM1 use for HER2-positive mBC patients in the nation-wide real-world setting. Method: This complete enumeration study included the patients with HER2-positive mBC who received T-DM1 as palliative therapy from August 2017 to December 2018 under the registry of Health Insurance Review
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18

Jung, Jinwon, Juhee Kim, Bora Lee, et al. "Abstract 6296: Preclinical study of a novel anti-CLEC12A antibody-drug conjugate with a glucuronide-protected pyrrolobenzodiazepine payload." Cancer Research 83, no. 7_Supplement (2023): 6296. http://dx.doi.org/10.1158/1538-7445.am2023-6296.

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Abstract C-type lectin domain family 12 member A (CLEC12A, CLL-1) is a single-pass transmembrane protein of 265 amino acids that is found on monocytes and AML blasts. We have created and characterized antibody-drug conjugates (ADCs) based on a humanized CLEC12A specific antibody to determine whether CLEC12A may be exploited as a therapeutic target for AML. The payload is a proprietary PBD prodrug with a beta-glucuronide trigger, and the linker-payload was conjugated through farnesyltransferase-mediated functionalization. The ADC demonstrated sub-nM cytotoxicity in vitro against several CLEC12A
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19

Lee, Ho-Jeong, Hyerim Yoo, Jihye Kim, et al. "Abstract 4185: A novel USP1 inhibitor enhances PARP inhibitor efficacy in elevated replication stress tumors: Evidence from BRCA-mutant and CCNE1-amplified models." Cancer Research 85, no. 8_Supplement_1 (2025): 4185. https://doi.org/10.1158/1538-7445.am2025-4185.

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Abstract Synthetic lethality offers a promising strategy for cancers with elevated replication stress, including BRCA-mutant and CCNE1-amplified tumors. USP1, a deubiquitinating enzyme, stabilizes replication forks by regulating ubiquitinated PCNA (Ub-PCNA). Using the AIGEN ChemTailor AI platform, we developed a novel USP1 inhibitor, which exhibited selective anti-proliferative effects in BRCA-mutant cancer cells and enhanced efficacy when combined with PARP inhibitors in vitro. We evaluated the USP1 inhibitor’s in vivo efficacy in BRCA-mutant breast cancer models and CCNE1-amplified ovarian c
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20

Kim, Seoree, Heejin Lee, Jung-Sook Yoon та ін. "Abstract 2165: Identification and characterization of Karyopherin α2 (KPNA2), a member of the nucleocytoplasmic transporter family, in lung cancer". Cancer Research 83, № 7_Supplement (2023): 2165. http://dx.doi.org/10.1158/1538-7445.am2023-2165.

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Abstract Introduction: Many oncologists began to make sense, that the Karyopherin a-2 (KPNA2), a nucleocytoplasmic transport protein, regulates the nuclear import of macromolecules and changes in cellular phenotype. In particular, it can be a poor prognostic marker by causing aberrant subcellular localization of DNA damage response proteins or OCT4-c MYC pathway molecules depending on the type of carcinoma. An association with the p53 oncogenic pathway has been reported, showing good prognostic values in other types. We aimed to investigate the clinical significance and metabolic pathway of st
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21

Zhang, Xin, and Xiaoxiao Zheng. "Optimal Investment-Reinsurance Policy with Stochastic Interest and Inflation Rates." Mathematical Problems in Engineering 2019 (December 17, 2019): 1–14. http://dx.doi.org/10.1155/2019/5176172.

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The aim of this paper is to study a classic problem in actuarial mathematics, namely, an optimal reinsurance-investment problem, in the presence of stochastic interest and inflation rates. This is of relevance since insurers make investment and risk management decisions over a relatively long horizon where uncertainty about interest rate and inflation rate may have significant impacts on these decisions. We consider the situation where three investment opportunities, namely, a savings account, a share, and a bond, are available to an insurer in a security market. In the meantime, the insurer t
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22

Kim, Hyemin, Jin Ho Choi, Hyoung-oh Jeong, et al. "Abstract 5197: Identification of novel molecular biomarkers for predicting postoperative recurrence of ampulla of Vater carcinoma." Cancer Research 84, no. 6_Supplement (2024): 5197. http://dx.doi.org/10.1158/1538-7445.am2024-5197.

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Abstract Background: Ampulla of Vater (AoV) carcinoma is a rare tumor that accounts for 20 % of periampullary cancers. Surgical resection is the only treatment that can expect cure of disease, and there is still an unmet need to predict postoperative recurrence. In this study, we investigated the novel molecular biomarkers that can predict the risk of recurrence after surgery with AoV carcinoma. Methods: In this retrospective study, we collected the surgically resected tissue and medical records of patients who were diagnosed with AoV carcinoma at Samsung Medical Center from January 2005 to De
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23

Lee, Mi Rim, sumin Kang, Jonghyun Lee, et al. "Abstract 5204: Morphology-guided classification of oral cancer using patient-derived organoids and its therapeutic implications." Cancer Research 85, no. 8_Supplement_1 (2025): 5204. https://doi.org/10.1158/1538-7445.am2025-5204.

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Abstract Oral cancer is an aggressive malignancy with a survival rate below 50% and a high rate of locoregional recurrence in advanced stages. The treatment method for patients with oral cancer is highly dependent on surgery and radiation, because there is still no therapeutic target due to the low mutation rate and the absence of molecular subtypes due to high tumor heterogeneity. Patient-derived organoid (PDO) is a good model that can overcome the limitations in translational study of oral cancer, as they reflect the characteristics of patient tissues at a high level and serve as a valuable
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24

Seo, Yu Ri, Hyeong Ji Lee, Seung Rok Yu та ін. "Abstract 4813: Multi-armored allogeneic CD5 γδ CAR T cells enhance anti-tumor efficacy in T cell malignancies". Cancer Research 85, № 8_Supplement_1 (2025): 4813. https://doi.org/10.1158/1538-7445.am2025-4813.

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T cell malignancies, such as T cell lymphoma and leukemia (T-NHL/T-ALL), present substantial challenges to conventional first-line therapies, highlighting an urgent need for novel therapeutic approaches. CAR-T therapies targeting T-cell-specific antigens have emerged as promising strategies against these cancers. However, the risk of tumor contamination by patient-derived T cells underscores the necessity for developing allogeneic, blast-free CAR-T therapies. Healthy donor-derived γδ T cells are attractive candidates for allogeneic CAR-T cell therapy due to their blast-free nature and the mini
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25

Kim, So Hyun, Jihye Lee, Jiyoung Song, et al. "Abstract 6060: Discovery of potent SHP2 protein degraders with strong anti-tumor activities in KRAS mutant cancers." Cancer Research 84, no. 6_Supplement (2024): 6060. http://dx.doi.org/10.1158/1538-7445.am2024-6060.

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Abstract Background: SHP2 plays a pivotal role in modulating the RTK/RAS/MAPK signaling pathway, which is frequently dysregulated in various cancers. Multiple allosteric SHP2 inhibitors have been under active development for the treatment of RTK/RAS/MAPK-dependent cancers, while certain limitations have come to light, such as their inability to target the active form of SHP2 and narrow therapeutic index necessitating intermittent dosing to mitigate toxicity. To overcome these challenges, we have discovered SHP2 protein degraders as next generation SHP2 targeting agents. Here, we present compel
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26

Jere, Stanley, Elias R. Offen, and Othusitse Basmanebothe. "Optimal Investment, Consumption and Life Insurance Problem with Stochastic Environments." Journal of Mathematics Research 14, no. 4 (2022): 33. http://dx.doi.org/10.5539/jmr.v14n4p33.

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Optimal investment, consumption and life insurance problem with stochastic environments for a CRRA wage-earner is solved in this study.  The wage-earner invests in the financial market with one risk-free security, one risky security, receives labor income and has a life insurance policy in the insurance market. A life insurance policy is purchased to hedge the financial wealth for the beneficiary in case of wage earner premature death. The interest rate and the volatility are stochastic. The stochastic interest rate dynamics of risk-free security follow a Ho-Lee model and the risky se
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27

Lee, Jeong Ho, Hyun Jung Kim, and Seok-Gu Kang. "Abstract 106: Intratumoral heterogeneity of glioblastoma is attributed to precancerous cells derived from neural stem cells." Cancer Research 83, no. 7_Supplement (2023): 106. http://dx.doi.org/10.1158/1538-7445.am2023-106.

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Abstract Glioblastoma (GBM) is the most common and aggressive primary brain cancer in adults. We and other groups have identified mutation-harboring neural stem cells (NSCs) in the subventricular zone (SVZ) as cells-of-origin carrying driver mutations (Lee et al, Nature 2018). However, little is known about the evolutional process by which mutation-harboring NSCs in the SVZ transform into distant cancer cells with a high degree of molecular heterogeneity. Here, using a spontaneous, somatic mouse model that recapitulates human GBM arising from NSCs that carry driver mutations, we show that muta
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28

Lim, Ye Seul, Na-rae Jeong, Sun-Mi Yoo, et al. "Abstract 5591: Development of a BCR-ABL degrader overcoming resistance by BCR-ABL1 kinase domain mutations in chronic myeloid leukemia." Cancer Research 85, no. 8_Supplement_1 (2025): 5591. https://doi.org/10.1158/1538-7445.am2025-5591.

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Abstract Chronic myeloid leukemia (CML) is a clonal hematopoietic stem cell disorder characterized by the presence of the BCR::ABL1 fusion gene. Tyrosine kinase inhibitors (TKIs) have revolutionized the treatment of CML, yielding remarkable responses in patients. However, resistance mutations within the BCR-ABL1 kinase domain can arise, leading to treatment failure and disease progression. In this study, we report the identification of potent, orally efficacious BCR-ABL1 PROTACs. UBX-362 exhibits strong degradation activity against BCR-ABL1 proteins in CML cell lines. Consistently, it effectiv
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29

Umroh, Hijjatul, Budi Sanjaya, and Ahmad Ridwan. "Pengembangan Media Pembelajaran Ispring Suite 9 pada Mata Pelajaran Pendidikan Agama Islam dalam Peningkatan Hasil Belajar Siswa." Al-Aulia: Jurnal Pendidikan dan Ilmu-Ilmu Keislaman 9, no. 2 (2023): 102–18. http://dx.doi.org/10.46963/aulia.v9i2.1377.

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This research is Research and Development (R&D) research with the ADDIE (Analysis, Design, Development, Implementation, and Evaluation) development model developed by Lee & Owens. With data analysis techniques, namely qualitative and quantitative data obtained from product quality assessment questionnaires and hypothesis testing using one-way ANOVA. This research shows the level of suitability of the iSpring Suite 9 learning media in the subject of Islamic Religious Education, the average assessment by material experts is 4.61 indicating the "Very Appropriate" category, while the avera
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30

Andrés-Sánchez, Jorge de. "A Systematic Overview of Fuzzy-Random Option Pricing in Discrete Time and Fuzzy-Random Binomial Extension Sensitive Interest Rate Pricing." Axioms 14, no. 1 (2025): 52. https://doi.org/10.3390/axioms14010052.

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Since the early 2000s, fuzzy mathematics has fostered a stream of research on the financial valuation of assets incorporating optionality. This paper makes two contributions to this field. First, it conducts a bibliographical analysis of contributions from fuzzy set theory to option pricing, focusing on fuzzy-random option pricing (FROP) and its applications in binomial and trinomial lattice approaches. Second, it extends the FROP to yield curve modeling within a binomial framework. The bibliographical analysis followed the PRISMA guidelines and was conducted via the SCOPUS and WoS databases.
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31

Park, Hong-June. "Praxeology in the Mosh Pit: Event Promotion and Global Networks in the Indonesian-Korean Metal Scene, 2017-2025." Academic Association of Global Cultural Contents 63 (May 31, 2025): 45–80. https://doi.org/10.32611/jgcc.2025.5.63.45.

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This article explores the Indonesian-Korean metal music scene (2017-2025), using ethnography and quantitative analysis informed by praxeological theory. It focuses on how individuals in loosely structured networks strategically deploy trust, reciprocity, and resources to facilitate sustained cross-border collaborations. Drawing on eight years of participant observation, the study foregrounds key cultural brokers such as Jae Ho “Thumbo” Lee—founder of Korea’s sole surviving metal booking agency—and Indonesian promoter Stephanus Adjie, organizer of Rock In Solo, one of Indonesia’s largest annual
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32

Wang, L. Ling-chi. "Model Minority, High-tech Coolies, and Foreign Spies: Asian Americans in Science and Technology, with Special Reference to the Case of Dr. Wen Ho Lee." Amerasia Journal 33, no. 1 (2007): 49–62. http://dx.doi.org/10.17953/amer.33.1.t086q80881t36t16.

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33

Lee, Youngrae, Sujeong Baek, Dong Kwon Kim, et al. "Abstract 3234: OCT-598, a novel EP2/EP4 dual antagonist, promotes anti-tumor immune responses in syngeneic mouse tumor models in combination with standard-of-care chemo- and immunotherapies." Cancer Research 83, no. 7_Supplement (2023): 3234. http://dx.doi.org/10.1158/1538-7445.am2023-3234.

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Abstract Prostaglandin E2 (PGE2) is widely recognized as one of the major bioactive lipids that, with the striking regenerative potential, promote drug-resistance in cancer cells as well as immune evasion in the tumor microenvironment (TME). Primarily driven by apoptotic cell death, PGE2 is thought to elicit wound-healing responses to help provide an immunosuppressive and proliferative niche that supports cancer stem cell repopulation and thereby therapy-resistance. While COX1/2 inhibitors that attenuate PGE2 production have shown promising anti-cancer effects in various (pre-)clinical setting
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Kang, Sumin, Mi Rim Lee, Jonghyun Lee, et al. "Abstract 1824: Harnessing a radiation-resistant organoid platform to propose novel strategies for precision treatment of advanced oral cancer." Cancer Research 85, no. 8_Supplement_1 (2025): 1824. https://doi.org/10.1158/1538-7445.am2025-1824.

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Abstract Oral squamous cell carcinoma (OSCC) has high recurrence rates and limited treatment options, with 40-60% of patients diagnosed at advanced stages (III/IV). Despite surgery following radiotherapy, over 40% of patients with advanced OSCC experience recurrence, with 70% being locoregional. Postoperative radiotherapy reduces recurrence but causes significant side effects, such as xerostomia and osteoradionecrosis. The challenge of accurately reflecting the clinical characteristics and tumor heterogeneity of oral cancer hinders clinical application. Therefore, research models that preserve
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Park, Jihye, Sieun Lee, Soon Auck Hong, Yoon Ho Ko, and Young-Ho Ahn. "Abstract 3802: miR-199a and miR-199b stimulate the progression of diffuse gastric cancer through direct targeting of Frizzled-6." Cancer Research 83, no. 7_Supplement (2023): 3802. http://dx.doi.org/10.1158/1538-7445.am2023-3802.

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Abstract There is no pathological difference between early and advanced diffuse gastric cancer (DGC), particularly in the gastric mucosa. In this study, we tried to identify microRNAs (miRNAs) as diagnostic biomarkers that can differentiate between early and advanced DGC. miRNA expression profiling was performed by NanoString nCounter method in human DGC tumors. miR-199a and miR-199b (miR-199a/b) were particularly up-regulated in advanced DGC compared with early DGC. Ectopic expression of miR-199a/b accelerated growth, viability, and motility of SNU601, human GC cells, and expedited tumor deve
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Suharto, Istiqomah, and Siti Hadiaty Yuningsih. "Exploring Interest Rate Models: Implications on Bond Value Measures in a Dynamic Financial Landscape." International Journal of Global Operations Research 5, no. 2 (2024): 139–46. http://dx.doi.org/10.47194/ijgor.v5i2.301.

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This paper investigates the impact of various one-factor no-arbitrage interest rate models on key bond value measures, specifically effective duration. Employing numerical methods based on binomial or trinomial lattices, the study assesses five prominent interest rate models: Ho and Lee, Kalotay, Williams, and Fabozzi, Black, Derman, and Toy, Hull and White, and Black and Karasinski.The analysis begins by outlining the theoretical foundations and assumptions underlying each model, highlighting their distinctive features and implications for bond valuation. Through a meticulous numerical soluti
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37

Kim, Jihye, Sejeong Park, Sunkyu Kim, et al. "Abstract 3324: Discovery of a novel SOS1 inhibitor, AIG01012, targeting pan-KRAS mutant cancers." Cancer Research 84, no. 6_Supplement (2024): 3324. http://dx.doi.org/10.1158/1538-7445.am2024-3324.

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Abstract Targeting the SOS1-KRAS interaction represents a pivotal strategy in mitigating aberrant KRAS signaling, which is implicated in numerous malignancies. At AIGEN Sciences, Inc., we have harnessed an advanced human-in-the-loop (HITL) AI-based drug discovery platform (AIGEN ChemTailor). This innovative platform allows online learning through expert feedback, optimizing our drug development endeavors. We designed a potent SOS1 inhibitor, AIG01012 using AIGEN ChemTailor in combination with fragment-based drug discovery (FBDD) and molecular modeling techniques. We conceived numerous compound
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Kim, Jiyoung, Ji Youn Park, Yeajin Woo, et al. "Abstract 7008: Development of a potent SOS1 degrader exhibiting superior combination effects with anti-cancer drugs in various tumor models." Cancer Research 85, no. 8_Supplement_1 (2025): 7008. https://doi.org/10.1158/1538-7445.am2025-7008.

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Abstract Background: Son of Sevenless 1 (SOS1) is a crucial guanine exchange factor (GEF) for KRAS, facilitating the activation of RAS family proteins by promoting the exchange of GDP for GTP at its catalytic site. It also binds GTP-bound KRAS at an allosteric site, enhancing its GEF activity through positive feedback. Loss or genetic inactivation of SOS1's GEF function reduces the survival of tumor cells with KRAS mutations. Additionally, SOS1 is subject to MAPK-mediated negative feedback inhibition and drugs targeting upstream and downstream nodes relieves SOS1 from this inhibition resulting
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Jeong, Joseph H., Young-Kyun Chang, You-Yeon Kang, et al. "Abstract LB090: IL-18 secreting chimeric antigen receptor T cells targeting glypican-3show superior persistence and antitumor immunity against hepatocellular carcinoma." Cancer Research 83, no. 8_Supplement (2023): LB090. http://dx.doi.org/10.1158/1538-7445.am2023-lb090.

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Abstract Over the last decade, immunotherapy has revolutionized the way we treat cancer primarily by boosting the body’s own immune system to help fight cancer. In particular, an engineered T cell therapy, namely chimeric antigen receptor (CAR) T cell therapy, is a more aggressive way to modify T cells to recognize cancer cells and destroy them. Although these CAR-T therapies have shown remarkable clinical responses in patients with hematological malignancies, their efficacy in solid tumor treatment has been disappointing due to many challenges: lack of tumor-specific antigen targets, loss of
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40

Li, Xue, Hyun Jung Kim, Jeong Ho Lee, Hong-Gyun Wu, and Joo Ho Lee. "Abstract 904: Neural stem cells of the subventricular zone evolve into tumors around the resection cavity after surgical resection of glioblastoma via the CXCL12/CXCR4 axis." Cancer Research 82, no. 12_Supplement (2022): 904. http://dx.doi.org/10.1158/1538-7445.am2022-904.

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Abstract Glioblastoma multiforme (GBM) is the most common lethal primary brain tumor. Neural stem cells (NSCs) harboring cancer-driving mutations in the subventricular zone (SVZ) have recently been reported as the cells of origin for human glioblastoma (GBM) through migration. However, the pathological role of residual tumor-initiating NSCs (tNSCs) in the SVZ is undetermined for local recurrent tumor after surgical removal of the primary tumor. After the primary resection of GBM, most recurrences still appear as local tumors around the resection cavity (RC). Accordingly, we hypothesized that,
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Cheon, Inyoung, Seoree Kim, Sengran Cho та ін. "Abstract 7269: Karyopherin α-2, a nuclear export protein, promotes cancer progression in lung adenocarcinoma". Cancer Research 84, № 6_Supplement (2024): 7269. http://dx.doi.org/10.1158/1538-7445.am2024-7269.

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Abstract Introduction: Karyopherin α-2 (KPNA2), a nucleocytoplasmic transport protein, regulates the nuclear import of macromolecules and contributes to carcinogenesis. Actually, KPNA2 is upregulated in various types of cancer tissues and serum from cancer patients. In particular, it is associated with cancer invasiveness and poor prognosis in patient. Here, we tried to present the molecular mechanism and clinical significance of KPNA2 in lung cancer progression and metastasis. Method: First, we retrospectively analyzed the data extracted from EMR for patients with non-small cell lung cancer r
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Lee, Jieun, Jung Eun Kim, Sanjun Lee, et al. "Abstract 5322: High throughput chemotherapeutic drug screening system for gastric cancer: cure-GA." Cancer Research 83, no. 7_Supplement (2023): 5322. http://dx.doi.org/10.1158/1538-7445.am2023-5322.

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Abstract To discover clinically applicable anticancer drugs and predict therapeutic response for advanced gastric cancer, we developed a high-throughput drug (HTD) screening system that could rapidly evaluate drug reactivity using 3D cultured primary cells derived from gastric cancer (GC) patients. Primary cancer cells were isolated from fresh surgical specimens that resected from 143 GC patients using Gentle Max tissue dissociation system. Primary cells were mixed with Matrigel, and placed on a micropillar for three-dimensional (3D) culture. After the primary cells were stabilized in the comp
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Hou, Zhaozheng, Ping Feng, Kazi Anisha Islam, et al. "Abstract 1106: RNA-based risk model for nasopharyngeal carcinoma distant metastasis." Cancer Research 85, no. 8_Supplement_1 (2025): 1106. https://doi.org/10.1158/1538-7445.am2025-1106.

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Abstract Background: With advancements in the treatment of nasopharyngeal carcinoma (NPC), the five-year relative survival rate for patients has the potential to reach upwards of 90%. However, patients who develop distant metastases after receiving primary treatment suffer from a significantly reduced survival rate. Method: We analyzed bulk-RNA sequencing of primary NPC biopsies and clinical characteristics from 177 patients across multiple centers. We established a prediction model for distant metastasis and patient stratification in NPC. Patients diagnosed with NPC at four Hong Kong hospital
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Chew, S. Y., S. K. Ho, P. P. Wong, and Y. Y. Leong. "BEACH DEVELOPMENT BETWEEN HEADLAND BREAKWATERS IN A LOW WAVE ENERGY ENVIRONMENT, PASIR RIS, SINGAPORE." Coastal Engineering Proceedings 1, no. 20 (1986): 76. http://dx.doi.org/10.9753/icce.v20.76.

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One of the function of the offshore breakwater is to protect the coast from wave action. By dissipating the wave energy along its entire length, the breakwater causes sediments in its lee to deposit and a shore salient is formed. If the offshore breakwater are placed in a series along a coast with a gentle offshore slope and a substantial littoral drift tombolo will form behind the breakwaters between which bays will be sculptured by waves to form stable shapes (1). These attached breakwater would thus form a series of artificial headlands. In nature, beaches between headlands are influenced b
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Shin, Dong Seung, Janghee Lee, Jong-Ho Cheun, et al. "Abstract PO5-26-05: Machine learning-based risk prediction for late distant recurrence in young women with estrogen receptor-positive/human epidermal growth factor 2-negative breast cancer." Cancer Research 84, no. 9_Supplement (2024): PO5–26–05—PO5–26–05. http://dx.doi.org/10.1158/1538-7445.sabcs23-po5-26-05.

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Abstract Background There is a clinical unmet need to predict the risk of late recurrence in premenopausal women with estrogen receptor (ER)-positive/human epidermal growth factor 2 (HER2)-negative breast cancer (BC) who completed endocrine treatment (ET). Previous studies suggest that the CTS5 model, developed using data from cohorts with postmenopausal women and predicts a likelihood of late recurrence after five years of ET, is not highly predictive in premenopausal women. We developed a machine learning-based model predicting the chance of late distant recurrence (DR) using multi-instituti
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Kim, Dong Kwon, Sujeong Baek, Seung Min Yang, et al. "Abstract 4039: Enhanced anti-cancer efficacy of the AhR Inhibitor DA-4505 in combination with anti-PD-1 treatment: Attenuation of lung metastasis and elimination of tumor." Cancer Research 84, no. 6_Supplement (2024): 4039. http://dx.doi.org/10.1158/1538-7445.am2024-4039.

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Abstract Background: The Aryl hydrocarbon receptor (AhR) is one of the most predominant regulators of cancer metabolism. AhR plays a crucial role in inhibiting the activation of immune cells and promoting the growth of tumor cells. Here, we propose that a best-in-class AhR inhibitor, DA-4505, improves anti-tumor efficacy in combination with anti-PD-1. Methods: To explore the anti-tumor effects, DA-4505 was administered at a daily dose of 10 mg/kg either alone or in combination with anti-PD-1 (10 mg/kg) in a syngeneic mouse model. Tumor volume, survival rates, and metastasis were measured, and
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Huang, Wan-Ting, Chee Ho Chew, Amanda Chen, et al. "Abstract 200: Microtube Array Membrane-Hollow Fiber Assay (MTAM-HFA): A combination of immunocheckpoint blocker (ICBs) and secondary drug anti-cancer drug screening system with significant clinical value propositions for personalized medicine and pre-clinical drug development." Cancer Research 82, no. 12_Supplement (2022): 200. http://dx.doi.org/10.1158/1538-7445.am2022-200.

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Abstract Despite modern advances in technology, significant challenges still plague the development of new cancer drugs and cancer care. To address these issue, we are introducing our novel platform technology- Microtube Array Membrane-Hollow Fiber Assay (MTAM-HFA) that is based on combination of the patented MTAM membrane with unique microstructures; replacing the role of traditional hollow fibers enabled the entire HFA assay to be significantly improved in terms of clinical relevance, accuracy, reliability and cost resulting in unprecedented value propositions as an anti-cancer drug screenin
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Lee, Tae-Rim, Jin Mo Ahn, Junnam Lee, et al. "Abstract 2411: A deep learning-based multimodal ensemble algorithm for lung cancer early detection with cross-ethnic generalizability." Cancer Research 84, no. 6_Supplement (2024): 2411. http://dx.doi.org/10.1158/1538-7445.am2024-2411.

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Abstract Background: Lung cancer is the leading cause of cancer-related mortality worldwide, and early detection is crucial for improving patient outcomes. Cell-free DNA (cfDNA) whole genome sequencing (WGS) is a non-invasive technique that has the potential to detect lung cancer early, but it is challenging to develop accurate and generalizable detection algorithms due to the low abundance of tumor-derived cfDNA in early-stage cancer. Methods: We developed a novel deep learning-based multimodal ensemble algorithm that combined two independent models: FEMS (fragment end motif frequency and siz
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Lee, S., J. Raygoza Garay, W. Turpin, et al. "A236 ASSOCIATION OF STOOL METABOLOMIC PROFILE AND MICROBIOME COMPOSITION RISK SCORE WITH FUTURE ONSET OF CROHN’S DISEASE." Journal of the Canadian Association of Gastroenterology 5, Supplement_1 (2022): 127–29. http://dx.doi.org/10.1093/jcag/gwab049.235.

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Abstract Background Microbial composition-based risk score (MRS) was recently developed and validated to predict future risk of developing Crohn’s disease (CD) among healthy first-degree relatives (FDR) of CD patients. We hypothesized that stool metabolomic profiles, some of which are linked to the gut microbiome, are associated with future risk of CD. Aims To assess the association of stool metabolomic profile with onset of CD and to determine the correlation between stool metabolites and the MRS Methods Healthy FDR of CD patients were recruited as part of the nested case-control cohort of th
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Kim, Seo Woo, Hana Yu, Geon Ho Lee, et al. "Abstract B030: ABC101-1, a novel microtubule inhibitor antibody-drug conjugate targeting HER2, has potent anti-tumor activity in a breast cancer model." Cancer Research 84, no. 3_Supplement_1 (2024): B030. http://dx.doi.org/10.1158/1538-7445.advbc23-b030.

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Abstract Background: ABC101-1 is an antibody-drug conjugate (ADC) targeting receptor tyrosine-protein kinase erbB-2, also known as HER2. ABC101-1 consists of a humanized IgG1 monoclonal antibody called trastuzumab conjugated to a microtubulin inhibitor, DM1, through interchain cysteines with a drug-to-antibody ratio (DAR) of 8. Our novel non-cleavable linker platform using maleimide as a connector enabled the construction of homogeneous ABC101-1 with DAR of 8, via a straightforward process resulting in high conjugation yield. Employing non-cleavable linkers may ensure that the cytotoxic drug i
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