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Journal articles on the topic 'The immune response of T lymphocyte cell'

Author: Grafiati

Published: 10 March 2023

Last updated: 31 July 2025

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1

García Ramírez, Patricia, Marta Callejas Charavia, Raquel Oliva Martin, et al. "SARS-CoV-2-Specific T Lymphocytes Analysis in mRNA-Vaccinated Patients with B-Cell Lymphoid Malignancies on Active Treatment." Vaccines 12, no. 9 (2024): 961. http://dx.doi.org/10.3390/vaccines12090961.

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Background: Patients with B-lymphocyte malignancies (BCMs) receiving B-lymphocyte-targeted therapies have increased risk of severe COVID-19 outcomes and impaired antibody response to SARS-CoV-2 mRNA vaccination in comparison to non-hematologic oncologic patients or general population. Consequently, it is vital to explore vaccine-induced T-lymphocyte responses in patients referred for the understanding of immune protection against SARS-CoV2 infections. The objective of the present study was to analyze the recall immune responses carried out by T lymphocytes after two COVID-19 mRNA vaccine doses

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2

Sen, Pritha, William A. Charini, Ramu A. Subbramanian, et al. "Clonal Focusing of Epitope-Specific CD8+ T Lymphocytes in Rhesus Monkeys following Vaccination and Simian-Human Immunodeficiency Virus Challenge." Journal of Virology 82, no. 2 (2007): 805–16. http://dx.doi.org/10.1128/jvi.01038-07.

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ABSTRACT To afford the greatest possible immune protection, candidate human immunodeficiency virus (HIV) vaccines must generate diverse and long-lasting CD8+ T lymphocyte responses. In the present study, we evaluate T-cell receptor Vβ (variable region beta) gene usage and a CDR3 (complementarity-determining region 3) sequence to assess the clonality of epitope-specific CD8+ T lymphocytes generated in rhesus monkeys following vaccination and simian-human immunodeficiency virus (SHIV) challenge. We found that vaccine-elicited epitope-specific CD8+ T lymphocytes have a clonal diversity comparable

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Li, Lijin, Sharon M. Dial, Monika Schmelz, Margaret A. Rennels, and Neil M. Ampel. "Cellular Immune Suppressor Activity Resides in Lymphocyte Cell Clusters Adjacent to Granulomata in Human Coccidioidomycosis." Infection and Immunity 73, no. 7 (2005): 3923–28. http://dx.doi.org/10.1128/iai.73.7.3923-3928.2005.

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ABSTRACT The in situ immunologic response in human coccidioidomycosis remains undefined. To explore this further, pulmonary necrotizing coccidioidal granulomata were examined using immunohistochemical staining for lymphocyte subsets and for the cytokines interleukin-10 (IL-10) and gamma interferon (IFN-γ). Discrete perigranulomatous lymphocytic clusters were seen in eight of nine tissues examined. In these tissues, T lymphocytes (CD3+) significantly outnumbered B lymphocytes (CD20+) in the mantle area of the granulomata (P = 0.028), whereas the clusters were composed of roughly equal numbers o

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Baszler, Timothy V., Varda Shkap, Waithaka Mwangi, et al. "Bovine Immune Response to Inoculation with Neospora caninum Surface Antigen SRS2 Lipopeptides Mimics Immune Response to Infection with Live Parasites." Clinical and Vaccine Immunology 15, no. 4 (2008): 659–67. http://dx.doi.org/10.1128/cvi.00436-07.

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ABSTRACT Infection of cattle with Neospora caninum protozoa, the causative agent of bovine protozoal abortion, results in robust cellular and humoral immune responses, particularly CD4+ T-lymphocyte activation and gamma interferon (IFN-γ) secretion. In the present study, N. caninum SRS2 (NcSRS2) T-lymphocyte-epitope-bearing subunits were incorporated into DNA and peptide preparations to assess CD4+ cell proliferation and IFN-γ T-lymphocyte-secretion immune responses in cattle with predetermined major histocompatibility complex (MHC) genotypes. In order to optimize dendritic-cell processing, Nc

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Kasaian, M. T., and C. A. Biron. "Effects of cyclosporin A on IL-2 production and lymphocyte proliferation during infection of mice with lymphocytic choriomeningitis virus." Journal of Immunology 144, no. 1 (1990): 299–306. http://dx.doi.org/10.4049/jimmunol.144.1.299.

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Abstract The immunosuppressive agent, cyclosporin A (CsA) blocks production of IL-2 by lymphocytes in vitro, and impairs immune responses in vivo. During infection of mice with lymphocytic choriomeningitis virus (LCMV), IL-2 is produced by spleen lymphocytes with a time course corresponding to that of T cell activation and proliferation, but distinct from NK cell activation and proliferation. To evaluate the requirement for IL-2 in supporting lymphocyte proliferation in vivo, and to investigate the mechanisms of CsA-induced immunosuppression, the effects of CsA on LCMV-elicited responses were

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Arsenio, Janilyn, Boyko Kakaradov, Gene Yeo, and John Chang. "Specification of CD8+ T lymphocyte fates during adaptive immunity revealed by single cell gene expression analyses (P1448)." Journal of Immunology 190, no. 1_Supplement (2013): 117.24. http://dx.doi.org/10.4049/jimmunol.190.supp.117.24.

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Abstract Although it is well established that heterogeneity of lymphocyte fate is an essential feature of adaptive immune responses, how and when these divergent cellular fates are specified remains unknown. It has been previously shown that a T lymphocyte responding to a microbial infection can undergo asymmetric division to yield two daughter cells that are differentially fated from inception. Such a model suggests that the progeny arising from each of the two differentially fated daughter cells might exhibit distinct patterns of gene expression. Because strategies analyzing bulk cell popula

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7

Parkman, Robertson, Geoff Cohen, Shelley L. Carter, et al. "Antigen-Specific T Lymphocyte Function Following Unrelated Cord Blood Transplantation (UCBT)." Blood 106, no. 11 (2005): 3032. http://dx.doi.org/10.1182/blood.v106.11.3032.3032.

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Abstract The T lymphocytes contained in cord blood are naïve and do not have antigen-specific function. Since the antigen-specific T lymphocytes contained in other hematopoietic stem cell (HSC) source may contribute to protective cellular immunity following transplantation, it has been hypothesized that the recipients of cord blood transplantation (CBT) might be at increased risk of opportunistic infections. The development of antigen-specific T lymphocyte function was measured in 153 recipients of unrelated cord blood transplants (UCBT) by determining antigen-specific T lymphocyte proliferat

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8

Puntigam, Lisa K., Sandra S. Jeske, Marlies Götz, et al. "Immune Checkpoint Expression on Immune Cells of HNSCC Patients and Modulation by Chemo- and Immunotherapy." International Journal of Molecular Sciences 21, no. 15 (2020): 5181. http://dx.doi.org/10.3390/ijms21155181.

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Endogenous control mechanisms, including immune checkpoints and immunosuppressive cells, are exploited in the process of tumorigenesis to weaken the anti-tumor immune response. Cancer treatment by chemotherapy or immune checkpoint inhibition can lead to changes of checkpoint expression, which influences therapy success. Peripheral blood lymphocytes (PBL) and tumor-infiltrating lymphocytes (TIL) were isolated from head and neck squamous cell carcinoma (HNSCC) patients (n = 23) and compared to healthy donors (n = 23). Immune checkpoint expression (programmed cell death ligand 1 (PD-1), tumor nec

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9

Manuel, Edwin R., William A. Charini, Pritha Sen, et al. "Contribution of T-Cell Receptor Repertoire Breadth to the Dominance of Epitope-Specific CD8+ T-Lymphocyte Responses." Journal of Virology 80, no. 24 (2006): 12032–40. http://dx.doi.org/10.1128/jvi.01479-06.

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ABSTRACT Dominant epitope-specific CD8+ T-lymphocyte responses play a central role in controlling viral spread. We explored the basis for the development of this focused immune response in simian immunodeficiency virus (SIV)- and simian-human immunodeficiency virus (SHIV)-infected rhesus monkeys through the use of two dominant (p11C and p199RY) and two subdominant (p68A and p56A) epitopes. Using real-time PCR to quantitate T-cell receptor (TCR) variable region beta (Vβ) family usage, we show that CD8+ T-lymphocyte populations specific for dominant epitopes are characterized by a diverse Vβ rep

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10

Trad, Malika, Alexandrine Gautheron, Jennifer Fraszczak, et al. "T Lymphocyte Inhibition by Tumor-Infiltrating Dendritic Cells Involves Ectonucleotidase CD39 but Not Arginase-1." BioMed Research International 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/891236.

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T lymphocytes activated by dendritic cells (DC) which present tumor antigens play a key role in the antitumor immune response. However, in patients suffering from active cancer, DC are not efficient at initiating and supporting immune responses as they participate to T lymphocyte inhibition. DC in the tumor environment are functionally defective and exhibit a characteristic of immature phenotype, different to that of DC present in nonpathological conditions. The mechanistic bases underlying DC dysfunction in cancer responsible for the modulation of T-cell responses and tumor immune escape are

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Cardone, Marco, Kyojiro N. Ikeda, Barbara Varano, Sandra Gessani та Lucia Conti. "HIV-1-Induced Impairment of Dendritic Cell Cross Talk with γδ T Lymphocytes". Journal of Virology 89, № 9 (2015): 4798–808. http://dx.doi.org/10.1128/jvi.03681-14.

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ABSTRACTThe interplay between dendritic cells (DC) and γδ T lymphocytes represents a network of paracrine and cell contact interactions important for an integrated immune response to pathogens. HIV-1 infection dramatically affects the number and functions of both cell populations, and DC/γδ T cell cross talk may represent a target of virus-induced immune escape. We investigated whether HIV-exposed DC could deliver aberrant signals to interacting γδ T cells. Here we report that the interaction of human γδ T lymphocytes with HIV-1-exposed autologous monocyte-derived DC, but not direct exposure t

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Soares, M. V. D., M. K. Maini, P. C. L. Beverley, M. Salmon, and A. N. Akbar. "Regulation of apoptosis and replicative senescence in CD8+ T cells from patients with viral infections." Biochemical Society Transactions 28, no. 2 (2000): 255–58. http://dx.doi.org/10.1042/bst0280255.

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Activated T lymphocytes are generated during an immune response. The induction of T lymphocyte proliferation is one way in which cell numbers can be controlled. However, once generated, the increased numbers of cells must be removed in order to re-establish cellular homoeostasis within the immune system. In this paper we describe how the numbers of activated T cells can be regulated by two distinct mechanisms, namely apoptosis and replicative senescence. In addition, we suggest that the regulation of cell clearance, as opposed to cell persistence, after an immune response is intimately involve

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Vlasova, V. V., and K. V. Shmagel. "T-Lymphocyte metabolic features and techniques to modulate them." Биохимия 88, no. 11 (2023): 2251–70. http://dx.doi.org/10.31857/s0320972523110167.

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T cells demonstrate a high degree of complexity and a broad range of functions which distinguish them from other immune cells. Throughout life, T lymphocytes experience several functional states: quiescence, activation, proliferation, differentiation, performance of effector and regulatory functions, memory formation, and apoptosis. Metabolism supports all the T cell functions, providing lymphocytes with energy, biosynthetic substrates, and signaling molecules. Therefore, T cells usually restructure their metabolism as they transition from one functional state to another. The strong associatio

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Meythaler, Mareike, Amanda Martinot, Zichun Wang, et al. "Differential CD4+ T-Lymphocyte Apoptosis and Bystander T-Cell Activation in Rhesus Macaques and Sooty Mangabeys during Acute Simian Immunodeficiency Virus Infection." Journal of Virology 83, no. 2 (2008): 572–83. http://dx.doi.org/10.1128/jvi.01715-08.

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ABSTRACT In contrast to pathogenic lentiviral infections, chronic simian immunodeficiency virus (SIV) infection in its natural host is characterized by a lack of increased immune activation and apoptosis. To determine whether these differences are species specific and predicted by the early host response to SIV in primary infection, we longitudinally examined T-lymphocyte apoptosis, immune activation, and the SIV-specific cellular immune response in experimentally infected rhesus macaques (RM) and sooty mangabeys (SM) with controlled or uncontrolled SIV infection. SIVsmE041, a primary SIVsm is

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15

Rahbar, Mahtab, Keykhosro Mardanpour, and Sourena Mardanpour. "CD8+ T-cell lymphocyte infiltration predict clinical outcomes Wilms’ tumor." Journal of Clinical Oncology 39, no. 15_suppl (2021): e22001-e22001. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e22001.

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e22001 Background: The abundance and location of CD8+ tumor-infiltrating lymphocytes demonstrate important facets of the anticancer immune response. CD8-expressing lymphocytes have been used in immunotherapy for multiple cancers. This study aims to determine the association between the abundance and localization of CD8+ tumor-infiltrating lymphocytes and clinical outcomes Wilms’ tumor. Methods: This retrospective study employed 42 pediatric patients diagnosed with Wilms’ tumor. CD8+ tumor-infiltrating lymphocyte counts were calculated based on the mean percentage of stroma occupied by CD8+ lym

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16

Dowd, Pauline S., J. Kelleher., and P. J. Guillou. "T-lymphocyte subsets and interleukin-2 production in zinc-deficient rats." British Journal of Nutrition 55, no. 1 (1986): 59–69. http://dx.doi.org/10.1079/bjn19860010.

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1. It has been suggested that zinc-deficiency impairs cellular (T-lymphocyte-mediated) immune responses via a selective effect on helper T-lymphocytes. We have addressed this question in the rat by employing recently developed reagents in the form of monoclonal antibodies which specifically identify rat T-lymphocyte subsets (identifying total T-cells, helper T-cells and suppressor T-cells) and also by quantifying helper T-cell function by measurement of the helper T-cell-derived molecule interleukin-2 (IL-2).2. Zn-deficiency induced T-cell atrophy (assessed morphologically and phenotypically w

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Jung, Jae Wook, Ae Rin Lee, Jaesung Kim, et al. "Elucidating the Functional Roles of Helper and Cytotoxic T Cells in the Cell-Mediated Immune Responses of Olive Flounder (Paralichthys olivaceus)." International Journal of Molecular Sciences 22, no. 2 (2021): 847. http://dx.doi.org/10.3390/ijms22020847.

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In higher vertebrates, helper and cytotoxic T cells, referred to as CD4 and CD8 T lymphocytes, respectively, are mainly associated with adaptive immunity. The adaptive immune system in teleosts involves T cells equivalent to those found in mammals. We previously generated monoclonal antibodies (mAbs) against olive flounder (Paralichthys olivaceus) CD4 T cells, CD4-1 and CD4-2, and used these to describe the olive flounder’s CD4 Tcell response during a viral infection. In the present study, we successfully produced mAbs against CD8 T lymphocytes and their specificities were confirmed using immu

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AL-Abedi, Yasameen Waleed, Ali Abdulhussein Alsaeedi, and Alaa Abdalhadi Halboti. "ROLE OF CYTOTOXIC T LYMPHOCYTE IN ADENOVIRUS INFECTION." European Journal of Medical Genetics and Clinical Biology 1, no. 3 (2024): 37–45. http://dx.doi.org/10.61796/jmgcb.v1i3.381.

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The successful development of adenovirus vectors for vaccines and gene therapy will require a better understanding of the host immune response. Using the ELISPOT assay to measure IFN-g-secreting CD8þ cells, we identify immunodominant epitopes of the adenovirus hexon and DNA-binding protein in BALB/c and C57BL/6 mice. The T-cell response to the intramuscular administration of adenovirus serotype 5 peaks within a few weeks and gradually declines but is still detectable after 12 weeks. A second administration did not substantially increase the number of reactive T cells. The CD8þ T-cell response

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Dobrynina, Maria A., Aleksandr V. Zurochka, Mariia V. Komelkova, Vladimir A. Zurochka, and Alexey P. Sarapultsev. "Disturbances in the b cell component of immune system and associated immune alterations in post-covid patients." Russian Journal of Immunology 26, no. 3 (2023): 241–50. http://dx.doi.org/10.46235/1028-7221-9636-dit.

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There is only limited data on B-cell response in post-COVID patients despite its importance in studying the post-infection immunity. The present study aimed to investigate the features of the B-cell response in post-COVID patients, focusing on various B cell phenotypes. Along with the standard immunogram, the following cell phenotypes were examined: common B cells (CD45+, CD3-, CD19+); common memory cells (CD45+, CD3-, CD19+, CD27+); common non-memory cells (CD45+, CD3-, CD19+, CD5+); B1 memory cells (CD45+, CD3-, CD19+, CD5+, CD27+); B2 memory cells (CD45+, CD3-, CD19+, CD5-, CD27+); B1 non-m

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Caruntu, Ana, Liliana Moraru, Mihaela Surcel, et al. "Persistent Changes of Peripheral Blood Lymphocyte Subsets in Patients with Oral Squamous Cell Carcinoma." Healthcare 10, no. 2 (2022): 342. http://dx.doi.org/10.3390/healthcare10020342.

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Background: Oral squamous cell carcinoma (OSCC) is a common cancer with high morbidity and mortality. Alterations of antitumor immune responses are involved in the development of this malignancy, and investigation of immune changes in the peripheral blood of OSCC patients has aroused the interest of researchers. Methods: In our study, we assessed the proportions of CD3+ total T lymphocytes, CD3+CD4+ helper T lymphocytes, CD3+CD8+ suppressor/cytotoxic T lymphocytes, CD3−CD19+ total B lymphocytes, and CD3−CD16+CD56+ NK cells in the peripheral blood of OSCC patients. Results: The data obtained bo

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Rajakariar, Ravindra, Toby Lawrence, Jonas Bystrom, et al. "Novel biphasic role for lymphocytes revealed during resolving inflammation." Blood 111, no. 8 (2008): 4184–92. http://dx.doi.org/10.1182/blood-2007-08-108936.

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Abstract Acute inflammation is traditionally described as the influx of polymorphonuclear leukocytes (PMNs) followed by monocyte-derived macrophages, leading to resolution. This is a classic view, and despite subpopulations of lymphocytes possessing innate immune-regulatory properties, seldom is their role in acute inflammation and its resolution discussed. To redress this we show, using lymphocyte-deficient RAG1−/− mice, that peritoneal T/B lymphocytes control PMN trafficking by regulating cytokine synthesis. Once inflammation ensues in normal mice, lymphocytes disappear in response to DP1 re

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Mardanpour, Keykhosro, Mahtab Rahbar, Sourena Mardanpour, Nyousha Mardanpour, and Mansour Rezaei. "CD8+ T-cell lymphocytes infiltration predict clinical outcomes in Wilms’ tumor." Tumor Biology 42, no. 12 (2020): 101042832097597. http://dx.doi.org/10.1177/1010428320975976.

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The abundance and location of CD8+ tumor-infiltrating lymphocytes demonstrate important facets of the anticancer immune response. CD8-expressing lymphocytes have been used in immunotherapy for multiple cancers. This study aims to determine the association between the abundance and localization of CD8+ tumor-infiltrating lymphocytes and clinical outcomes of Wilms’ tumor. This retrospective study employed 42 pediatric patients diagnosed with Wilms’ tumor. CD8+ tumor-infiltrating lymphocyte counts were calculated based on the mean percentage of stroma occupied by CD8+ lymphocytes at the center an

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Moussa Agha, Douâa, Redouane Rouas, Mehdi Najar, et al. "Impact of Bone Marrow miR-21 Expression on Acute Myeloid Leukemia T Lymphocyte Fragility and Dysfunction." Cells 9, no. 9 (2020): 2053. http://dx.doi.org/10.3390/cells9092053.

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Background: Acute myeloid leukemia (AML) is a hematopoietic malignancy in which antitumor immunity is impaired. The therapeutic management of AML requires understanding the mechanisms involved in the fragility and immune dysfunction of AML T lymphocytes. Methods: In this study, T lymphocytes from healthy donors (HD) and AML patients were used. Extracellular vesicles (EVs) from leukemic cells were screened for their microRNA content and impact on T lymphocytes. Flow cytometry, transcriptomic as well as lentiviral transduction techniques were used to carry out the research. Results: We observed

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Andjelíc, S., A. Khanna, M. Suthanthiran, and J. Nikolić-Zugić. "Intracellular Ca2+ elevation and cyclosporin A synergistically induce TGF-beta 1-mediated apoptosis in lymphocytes." Journal of Immunology 158, no. 6 (1997): 2527–34. http://dx.doi.org/10.4049/jimmunol.158.6.2527.

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Abstract Apoptosis plays an essential role in the development and homeostasis of the immune system. During lymphocyte development, potentially autoreactive cells are eliminated via the activation of a tightly regulated cell death program(s). Similar processes operate in mature lymphocytes, to control the magnitude of the normal immune response by eliminating activated lymphocytes. However, differences in susceptibility to signal-induced apoptosis between immature and mature lymphocytes are numerous. One well-characterized example occurs in response to Ca2+ elevation: peripheral T lymphocytes a

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Mohamed, Hager, Rachel Berman, Jennifer Connors, et al. "Immunomodulatory Effects of Non-Thermal Plasma in a Model for Latent HIV-1 Infection: Implications for an HIV-1-Specific Immunotherapy." Biomedicines 11, no. 1 (2023): 122. http://dx.doi.org/10.3390/biomedicines11010122.

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In people living with HIV-1 (PLWH), antiretroviral therapy (ART) eventually becomes necessary to suppress the emergence of human immunodeficiency virus type 1 (HIV-1) replication from latent reservoirs because HIV-1-specific immune responses in PLWH are suboptimal. Immunotherapies that enhance anti-HIV-1 immune responses for better control of virus reemergence from latent reservoirs are postulated to offer ART-free control of HIV-1. Toward the goal of developing an HIV-1-specific immunotherapy based on non-thermal plasma (NTP), the early immunological responses to NTP-exposed latently infected

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Grailer, Jamison J., Rochelle M. Conway, and Douglas A. Steeber. "Lymphocyte subset recruitment during an immune response differs between peripheral and mucosal lymphoid tissues (95.7)." Journal of Immunology 182, no. 1_Supplement (2009): 95.7. http://dx.doi.org/10.4049/jimmunol.182.supp.95.7.

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Abstract Lymphocyte recirculation through peripheral lymphoid tissue depends primarily on the adhesion molecules L-selectin and α4β7 integrin. While most naïve lymphocytes express both molecules, subset-specific differences exist. These differences, along with tissue-specific expression of vascular ligands, results in preferential migration patterns among subsets. In the present studies, lymphocyte subset migration into peripheral (PLN) and mesenteric lymph nodes (MLN) was examined following s.c. and oral immunization, respectively. Naïve CD4+ T cell migration into PLNs increased after s.c.

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Schirren, CA, H. Volpel, and SC Meuer. "Adhesion molecules on freshly recovered T leukemias promote tumor- directed lympholysis." Blood 79, no. 1 (1992): 138–43. http://dx.doi.org/10.1182/blood.v79.1.138.138.

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Abstract Besides facilitating cell to cell adhesion, the molecular interactions between CD2 and its ligand CD58 (lymphocyte function-associated antigen- 3 [LFA-3]), as well as between CD11a/18 (LFA-1) and CD54 (intercellular adhesion molecule-1) have recently been recognized to participate in lymphocyte activation, recirculation, and effector function, including cytolytic activity towards tumor cells. We have investigated the role of CD2/CD58 and CD11a/18/CD54 interactions in cellular immune responses directed towards freshly recovered human T-cell leukemias. The data support the notion that d

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Schirren, CA, H. Volpel, and SC Meuer. "Adhesion molecules on freshly recovered T leukemias promote tumor- directed lympholysis." Blood 79, no. 1 (1992): 138–43. http://dx.doi.org/10.1182/blood.v79.1.138.bloodjournal791138.

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Besides facilitating cell to cell adhesion, the molecular interactions between CD2 and its ligand CD58 (lymphocyte function-associated antigen- 3 [LFA-3]), as well as between CD11a/18 (LFA-1) and CD54 (intercellular adhesion molecule-1) have recently been recognized to participate in lymphocyte activation, recirculation, and effector function, including cytolytic activity towards tumor cells. We have investigated the role of CD2/CD58 and CD11a/18/CD54 interactions in cellular immune responses directed towards freshly recovered human T-cell leukemias. The data support the notion that downregula

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Mody, Christopher H., Cynthia J. Wood, Rachel M. Syme, and Jason C. L. Spurrell. "The Cell Wall and Membrane of Cryptococcus neoformans Possess a Mitogen for Human T Lymphocytes." Infection and Immunity 67, no. 2 (1999): 936–41. http://dx.doi.org/10.1128/iai.67.2.936-941.1999.

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ABSTRACT The mechanism of human T-lymphocyte activation by the pathogenic yeast Cryptococcus neoformans has not been established. Previous investigations have suggested that C. neoformanscontains a mitogen for T lymphocytes, while other investigators have attributed lymphocyte proliferation in vitro to a recall antigen. Because of the potential importance of the mechanism of T-cell activation for our understanding of the immune response toC. neoformans, the present studies were performed to determine whether C. neoformans contains a mitogen for T lymphocytes. C. neoformans stimulates fetal blo

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Hamra, Jena G., and Tony L. Yaksh. "Equianalgesic Doses of Subcutaneous but Not Intrathecal Morphine Alter Phenotypic Expression of Cell Surface Markers and Mitogen-induced Proliferation in Rat Lymphocytes." Anesthesiology 85, no. 2 (1996): 355–65. http://dx.doi.org/10.1097/00000542-199608000-00018.

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Background Surgical trauma and opioids are linked with suppression of immune function. Evidence suggests a probable supraspinal action of morphine in altering immune function, although the role of spinal systems have not been evaluated. Therefore, this study compared the effect of equianalgesic doses of subcutaneous and intrathecal morphine on lymphocyte proliferative responses and phenotypic expression of lymphocyte cell surface markers in rats. Methods Equianalgesic doses of subcutaneous (10 mg/kg) or intrathecal (30 micrograms, by a chronic intrathecal catheter) morphine were given twice fo

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Zheng, Rongjiong, Songsong Xie, Qiong Zhang, et al. "Circulating Th1, Th2, Th17, Treg, and PD-1 Levels in Patients with Brucellosis." Journal of Immunology Research 2019 (August 6, 2019): 1–15. http://dx.doi.org/10.1155/2019/3783209.

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Brucella is an intracellular infection bacterium; the pathogenesis of Brucella and chronicity of infection may be related to the immune response of T cells. T lymphocytes mainly participate in cellular immune response. The extent of different T cell subsets imbalanced and their function dysregulated in patients with brucellosis remain not explicit. We grouped patients at different stages (acute, chronic, and convalescent). The frequencies of Th1, Th2, Th17, Treg, and PD-1 (programmed cell death protein 1) in peripheral blood were examined by flow cytometry, and the expressions of T lymphocyte

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Ceylan, Ayca, Mehmet Artac, and Hasibe Artac. "Increased PD-1 and EGFR expression levels of T lymphocytes in patients with non-small cell lung cancer." Journal of Clinical Oncology 39, no. 15_suppl (2021): e21018-e21018. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e21018.

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e21018 Background: Programmed cell death protein 1 (PD-1) and its ligand (PD-L1) are proteins that negatively regulate immune responses. Increased expression of PD-L1 in cancer cells leads to inhibition of the immune response against cancer, and causes cancer development and metastasis. Epidermal growth factor receptor (EGFR) activation upregulates PD-L1 expression in lung cancer cells and contribute to escape from immune response. In this study, we aimed to investigate the circulating T lymphocyte subsets and, PD-1 and EGFR expression levels of these cells in non-small cell lung cancer (NSCLC

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Lis, Magdalena, Marianna Szczypka, Agnieszka Suszko-Pawłowska, Anna Sokół-Łętowska, Alicja Kucharska, and Bożena Obmińska-Mrukowicz. "Hawthorn (Crataegus monogyna) Phenolic Extract Modulates Lymphocyte Subsets and Humoral Immune Response in Mice." Planta Medica 86, no. 02 (2019): 160–68. http://dx.doi.org/10.1055/a-1045-5437.

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AbstractThis study investigated the effect of hawthorn (Crataegus monogyna) phenolic extract on lymphocyte subsets in the lymphoid organs in nonimmunized mice and on humoral immune response in sheep red blood cell-immunized mice. Hawthorn phenolic extract (50, 100, 200 mg/kg) was administered orally five or ten times. Sheep red blood cells were injected 24 h after administration of the last extract dose. The lymphocyte subsets were assessed 24 and 72 h after the last dose. Humoral immune response was determined 4 and 7 days after immunization. Five doses of the extract decreased the percentage

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Finkelman, F. D., J. Ohara, D. K. Goroff, et al. "Production of BSF-1 during an in vivo, T-dependent immune response." Journal of Immunology 137, no. 9 (1986): 2878–85. http://dx.doi.org/10.4049/jimmunol.137.9.2878.

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Abstract BSF-1, a cytokine produced by some T lymphocyte tumors, has been shown to act with anti-Ig antibodies to stimulate B lymphocyte proliferation, to independently induce resting B lymphocytes to increase their expression of surface Ia antigen, and to induce some activated B lymphocytes to differentiate into IgG1- or IgE-secreting cells. To determine whether BSF-1 might be secreted by normal lymphoid cells in the course of a physiologic immune response, BALB/c mice were injected with an affinity-purified goat antibody to mouse IgD (GaM delta), which induces the generation of a large, poly

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Bubanović, I., Z. Anðelković, M. Mirić, Z. Mirosavljević, and R. Mitić. "IMPORTANCE OF CYTOKINES IN REGULATION OF SPECIFIC IMMUNE RESPONSE." Praxis medica 32, no. 1 (2004): 61–65. http://dx.doi.org/10.70949/pramed200401070b.

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&lt;p&gt;In regulation of specific immune responses the most important role play interleukin-2, IL-4, IL-5, IL-13, inter feron- (INF- ), transforming growth factor- (TGF- ) and lymphotoxin (LT). These signal molecules are produced mainly by T-lymphocytes after recognition of foreign antigens by specific receptors (TCR) placed on plasmalema. Some of mentioned cytokines stimulate proliferation and differentiation of various lymphocyte populations in the activation phase of T cell-de pendent immune responses, while the others activate and regulate the function of specialized effector cell

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Ghaffari, Guity, Dominick J. Passalacqua, Bradley S. Bender, Debora J. Briggs, Maureen M. Goodenow, and John W. Sleasman. "Human Lymphocyte Proliferation Responses following Primary Immunization with Rabies Vaccine as Neoantigen." Clinical Diagnostic Laboratory Immunology 8, no. 5 (2001): 880–83. http://dx.doi.org/10.1128/cdli.8.5.880-883.2001.

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ABSTRACT Evaluation of the T-cell immune response following primary antigenic challenge with a neoantigen is a critical aspect of assessment of the cellular immune response. While many antigens can be used to accurately assess in vitro T-cell proliferation to a recall antigen, only a few neoantigens have been tested for their capacities to measure T-cell responses in vitro to a primary immunization. Rabies vaccination is an excellent candidate for the testing of T-cell proliferation responses to a primary immunization because few individuals have been exposed to rabies virus antigens. In the p

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Moll, J., A. Schmidt, H. van der Putten, et al. "Accelerated immune response in transgenic mice expressing rat CD44v4-v7 on T cells." Journal of Immunology 156, no. 6 (1996): 2085–94. http://dx.doi.org/10.4049/jimmunol.156.6.2085.

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Abstract Splice variants of the glycoprotein CD44 (CD44v) that confer metastatic behavior to noninvasively growing rat tumor cells are transiently expressed on lymphocytes during activation. A mAb directed against an epitope encoded by CD44 exon v6 blocks both metastasis formations and lymphocyte activation, implicating CD44v in normal immune function. To explore the nature of this function of CD44v, transgenic mice were generated that constitutively express rat CD44v4-v7 on thymocytes and peripheral T cells. The number of lymphocytes as well as the distribution of lymphocyte subpopulations we

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Asquith, Becca, Emmanuel Hanon, Graham P. Taylor, and Charles R. M. Bangham. "Is human T–cell lymphotropic virus type I really silent?" Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 355, no. 1400 (2000): 1013–19. http://dx.doi.org/10.1098/rstb.2000.0638.

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The role of the cellular immune response to human T–cell lymphotropic virus type I (HTLV–I) is not fully understood. The low level of HTLV–I protein expression in peripheral blood lymphocytes has led to the widely held belief that HTLV–I is transcriptionally silent in vivo . However, most HTLV–I–infected individuals mount a strong and persistently activated cytotoxic T–lymphocyte (CTL) response to the virus; this observation implies that there is abundant chronic transcription of HTLV–I genes. Here we show that HTLV–I Tax protein expression rises quickly in freshly isolated peripheral blood ly

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Pattanapanyasat, Kovit, Charin Thepthai, Pornvaree Lamchiagdhase, et al. "Lymphocyte subsets and specific T-cell immune response in thalassemia." Cytometry 42, no. 1 (2000): 11–17. http://dx.doi.org/10.1002/(sici)1097-0320(20000215)42:1<11::aid-cyto3>3.0.co;2-1.

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Coito, Ana J., Maria De Sousa, and Jerzy W. Kupiec-Weglinski. "Fibronectin in Immune Responses in Organ Transplant Recipients." Developmental Immunology 7, no. 2-4 (2000): 239–48. http://dx.doi.org/10.1155/2000/98187.

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The immune response to an organ allograft involves perpetuation of T cell infiltration and activation. Advances in understanding the mechanisms of T cell activation have placed particular emphasis on the interactions between the T-cell receptor and antigen presenting cells, with little reference to the fact that in vivo activation occurs in the physical context of extracellular matrix proteins (ECM). Indeed, the possibility that ECM proteins may have a determining role in lymphocyte adhesion and tissue localization and function is now becoming more appreciated in view of growing evidence indic

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Broström, Hans, Marita Troye-Bomberg, and Peter Perlmann. "Generation of in vitro natural cytotoxicity of horse lymphocytes against sarcoid-derived tumor cells not expressing major histocompatibility complex antigens." American Journal of Veterinary Research 57, no. 7 (1996): 992–99. http://dx.doi.org/10.2460/ajvr.1996.57.07.992.

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Abstract Objective To analyze in vitro lymphocyte-mediated immune responses of horses with sarcoids against allogeneic sarcoid cells containing endogenous retrovirus but not expressing major histocompatibility complex antigens. Design Lymphocyte-mediated immune reactions were assessed by means of proliferative responses in mixed lymphocyte tumor cell culture (MLTC) assay and lymphocyte-mediated cytotoxicity against various equine target cells. Animals 12 horses with sarcoid tumors and 15 control horses. Procedure Blood lymphocytes were cocultured in MLTC with allogeneic sarcoid cells (Mc-1, Ba

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Hickling, Julian K. "Measuring human T-lymphocyte function." Expert Reviews in Molecular Medicine 1, no. 6 (1998): 1–20. http://dx.doi.org/10.1017/s1462399498000313.

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T lymphocytes (T cells) play critical roles in the regulation of immune responses, and are responsible for mediating many of the effector mechanisms of the immune system. For this reason, there has always been a need for assays to measure accurately the activity of populations of T cells, both in model (animal) systems and in humans. The expansion of the biotechnology industry has led to a dramatic increase in the number of novel immunotherapeutics that are being developed for the treatment of cancer, autoimmune disorders and infectious diseases. This increase in activity in the field of immun

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Norimine, Junzo, Juan Mosqueda, Carlos Suarez, et al. "Stimulation of T-Helper Cell Gamma Interferon and Immunoglobulin G Responses Specific for Babesia bovis Rhoptry-Associated Protein 1 (RAP-1) or a RAP-1 Protein Lacking the Carboxy-Terminal Repeat Region Is Insufficient To Provide Protective Immunity against Virulent B. bovis Challenge." Infection and Immunity 71, no. 9 (2003): 5021–32. http://dx.doi.org/10.1128/iai.71.9.5021-5032.2003.

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ABSTRACT Rhoptry-associated protein 1 (RAP-1) is a targeted vaccine antigen for Babesia bovis and Babesia bigemina infections of cattle. The 60-kDa B. bovis RAP-1 is recognized by antibodies and T lymphocytes from cattle that recovered from infection and were immune to subsequent challenge. Immunization with native or recombinant protein was reported to reduce parasitemias in challenged animals. We recently reported that the NT domain of B. bovis RAP-1 contained immunodominant T-cell epitopes, whereas the repeat-rich CT domain was less immunostimulatory for T lymphocytes from cattle immune to

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Nazarenko, M. S., A. A. Sleptsov, and V. P. Puzyrev. "T-cell immune response in initiation, progression, and destabilization of atherosclerosis: a review." Russian Journal of Cardiology 29, no. 11S (2024): 6017. https://doi.org/10.15829/1560-4071-2024-6017.

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A detailed characterization of the diversity, clonality, and antigen specificity of the T-cell repertoire contributes to the understanding of the adaptive immune response role in a wide range of diseases, including arteriosclerosis. This article discusses the differentiation of T-lymphocytes and the factors leading to their activation in atherosclerosis. Furthermore, the article discusses the data obtained during the analysis of T-cell repertoires in carotid and coronary artery atherosclerosis using new sequencing technologies, such as single-cell sequencing. The importance and peculiarity of

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Singhatanadgit, Weerachai, Montree Toso, Boonsong Pratheepsawangwong, Alongkorn Pimpin, and Werayut Srituravanich. "Titanium dioxide nanotubes of defined diameter enhance mesenchymal stem cell proliferation via JNK- and ERK-dependent up-regulation of fibroblast growth factor-2 by T lymphocytes." Journal of Biomaterials Applications 33, no. 7 (2018): 997–1010. http://dx.doi.org/10.1177/0885328218816565.

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Long-term clinical success of a titanium implant not only depends upon osseointegration between implant and bone surface but also on the response of host immune cells. Following implantation of biomaterials, an inflammatory response, including T lymphocyte response, is ostensibly initiated by implant-cell interaction. However, little is known about the responses of T lymphocytes to titanium dioxide nanotubes. The present study aimed to explore the effect of titanium dioxide nanotubes on T lymphocytes in vitro and its biological consequences. The results of the present study showed that titaniu

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Gurevičienė, Giedrė, Jurgita Matulionė, Lina Poškienė, Skaidrius Miliauskas, and Marius Žemaitis. "PD-L1+ Lymphocytes Are Associated with CD4+, Foxp3+CD4+, IL17+CD4+ T Cells and Subtypes of Macrophages in Resected Early-Stage Non-Small Cell Lung Cancer." International Journal of Molecular Sciences 25, no. 19 (2024): 10827. http://dx.doi.org/10.3390/ijms251910827.

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The non-canonical PD-L1 pathway revealed that programmed-death ligand 1 (PD-L1) expression in immune cells also plays a crucial role in immune response. Moreover, immune cell distribution in a tumour microenvironment (TME) is pivotal for tumour genesis. However, the results remain controversial and further research is needed. Distribution of PD-L1-positive (PD-L1+) tumour-infiltrating lymphocytes in the context of TME was assessed in 72 archival I–III stage surgically resected NSCLC tumour specimens. Predominant PD-L1+ lymphocyte distribution in the tumour stroma, compared to islets, was found

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Reiss, C. S., D. Wang, D. Ghosh, C. Gaposchkin, and E. Kieff. "Recognition of EBV plasma membrane protein expressed on murine cells after gene transfer." Journal of Immunology 139, no. 3 (1987): 711–14. http://dx.doi.org/10.4049/jimmunol.139.3.711.

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Abstract The immune response to B lymphocytes infected with Epstein-Barr virus (EBV) prevents their overgrowth in normal humans. A murine model is now described for analyzing the T cell immune response to Epstein-Barr virus genes expressed in murine lymphoblasts by gene transfer. In mice, a 60,000 dalton virus-encoded protein characteristically found in the plasma membrane of latently infected human lymphocytes readily induces both proliferative and cytolytic T lymphocytes specific for both the EBV protein and murine major histocompatibility proteins. Longterm cultures of L3T4+ cells, some of

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Carrera, Maria. "Immune Checkpoints Acting as Gate-keepers of T Lymphocyte Self-renewal." Journal of Immunology 200, no. 1_Supplement (2018): 57.52. http://dx.doi.org/10.4049/jimmunol.200.supp.57.52.

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Abstract Immune checkpoint inhibition represents a promising therapeutic modality for several previously incurable cancer syndromes. Why successful T cell responses are achieved in some patients but not others is incompletely understood. Because blockade of more than one inhibitory signal is now being investigated as approach to increase the chances of therapeutic success, we investigated how combined loss of PD-1 and LAG-3 signaling in CD8+ T cells would influence a well-characterized immune response. After challenge with Vaccinia virus, T cells from mice lacking both inhibitory pathways unde

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Fleischer, Vinzenz, Michaela Friedrich, Ayman Rezk, et al. "Treatment response to dimethyl fumarate is characterized by disproportionate CD8+ T cell reduction in MS." Multiple Sclerosis Journal 24, no. 5 (2017): 632–41. http://dx.doi.org/10.1177/1352458517703799.

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Background: The effect of dimethyl fumarate (DMF) on circulating lymphocyte subsets and their contribution as predictors of clinical efficacy have not yet been investigated in multiple sclerosis (MS). Objective: To evaluate lymphocytes and lymphocyte subsets (analyzed 6 months after DMF start) in MS patients with and without disease activity after 1 year of treatment in a retrospective study. Methods: Peripheral blood lymphocyte subsets were analyzed by flow cytometry. Untreated MS patients ( n = 40) were compared to those 6 months after onset of DMF treatment ( n = 51). Clinical and magnetic

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Shmagel, K. V. "DISCORDANT RESPONSE OF CD4+ T LYMPHOCYTES TO ANTIRETROVIRAL THERAPY." HIV Infection and Immunosuppressive Disorders 11, no. 1 (2019): 16–30. http://dx.doi.org/10.22328/2077-9828-2019-11-1-16-30.

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Antiretroviral therapy (ART) in HIV infected patients generally results in the suppression of viral replication and reconstitution of CD4+ T lymphocytes cell counts. In some patients (about 20%), however, a disturbance in regeneration of immune competent cells with a background of low viral load occurs. The term «immunological nonresponders» has been used to describe this phenomenon. Discordant immune response to antiviral therapy may be caused by increasing of depletion and reducing of production of CD4+ T cells. However, mechanisms for low immune reconstitution are not currently well underst

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