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Journal articles on the topic 'The importance of Sh. Kholmirzayev's work'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Magera, T. N., and N. А. Shironina. "Motivators of team work in the construction industry." Smetno-dogovornaya rabota v stroitel'stve (Estimated and contractual work in construction), no. 1 (January 1, 2022): 67–74. http://dx.doi.org/10.33920/str-01-2201-10.

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The authors referred to the model of motivators of Richie Sh., Martin P. for the research of efficiency of team work in the construction industry on the example of the educational groups of the magistracy within construction higher education institution studying in the "Construction" direction, which are included in professional activity in the real construction organizations and the companies at the same time. The specifics of the motivational profile of the teams are defined, descriptive characteristics, opportunities and restrictions of such teams are revealed. The practical importance of t

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Martini, Agnese, Emma Pietrafesa, Antonella Polimeni, et al. "P-081 SLEEP-ROAD: A SERIOUS GAME FOR DRIVING HEALTH AND SAFETY." Occupational Medicine 74, Supplement_1 (2024): 0. http://dx.doi.org/10.1093/occmed/kqae023.0550.

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Abstract Introduction Global, European and national data show that road accidents RAs are an increasingly important cause of injury, disability and death (6/10 work-related fatalities in Europe). The road occupies an important part of our working time. The causes of work-related road injuries (WRRIs) and RAs are the same. Excessive sleepiness (caused by poor quantity and/or quality of sleep) is an important contributor to RAs, estimated to be the cause of about 25% of RAs. The aim of this study is to develop a video-game on sleep hygiene (SH) knowledge, promotion and education to mitigate the

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Swope, Curtis. "Is Green the New Red? Marxism, Ecology, and Contemporary Architectural Theory." Humanities 10, no. 1 (2021): 45. http://dx.doi.org/10.3390/h10010045.

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This essay examines the role of Marxist concepts in recent architectural theories of ecology using two architecture firms, Estudio Teddy Cruz and Sauerbruch Hutton (SH), as case studies. In their writings, Cruz and SH mobilize the critique of capital, a dialectical materialist understanding of history, and the Frankfurt School’s critique of functionalist culture for the theorization of sustainable design. Their work has two vital ramifications for current sustainability discourses in two different fields which this essay seeks to bridge. For Marxist theorists concerned about ecology but averse

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Minò, Antonio, Francesco Lopez, Roberto Barbaro, Maria Barile, Luigi Ambrosone, and Matilde Colella. "Effects of Anionic Liposome Delivery of All–Trans–Retinoic Acid on Neuroblastoma Cell Differentiation." Biomimetics 9, no. 5 (2024): 257. http://dx.doi.org/10.3390/biomimetics9050257.

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All–trans–retinoic acid (ATRA) has long been known to affect cell growth and differentiation. To improve ATRA’s therapeutic efficacy and pharmacodynamics, several delivery systems have been used. In this study, free ATRA and anionic–liposome–encapsulated ATRA were compared for their effects on SK–N–SH human neuroblastoma cell growth and differentiation. Anionic liposomes made of L–α–phosphatidylcholine (PC) and L–α–phosphatidic acid (PA), empty (PC–PA) and loaded with ATRA (PC–PA–ATRA), were characterized by dynamic light scattering (DLS) and electrophoretic mobility measurements, and drug ent

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Д.А., Мансурова, та Каражанова Л.К. "ЭТИОЛОГИЧЕСКИЕ И КЛИНИЧЕСКИЕ ПРЕДИКТОРЫ ВОЗВРАТНОЙ ИШЕМИИ МИОКАРДА". Наука и здравоохранение, № 6(17) (30 грудня 2015): 83–91. http://dx.doi.org/10.34689/sh.2015.17.6.008.

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В работе рассматривается проблема возврата симптомов ишемической болезни сердца (ИБС) у пациентов, перенесших реваскуляризацию миокарда (хирургическую и/или эндоваскулярную): распространенность факторов риска, особенности коронарного кровотока, «сосудистые» причины возвратной ишемии миокарда, вопросы приверженности к терапии. Целью нашего исследования было разработать эффективные меры вторичной профилактики для улучшения прогноза ИБС у пациентов после реваскуляризации миокарда. Обозначена важность создания обучающих школ для повышения информированности и приверженности к лечению. The problem o

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Gorman, Maire N., Sergei N. Yurchenko та Jonathan Tennyson. "ExoMol molecular line lists XXXVI: X 2Π – X 2Π and A 2Σ+ – X 2Π transitions of SH". Monthly Notices of the Royal Astronomical Society 490, № 2 (2019): 1652–65. http://dx.doi.org/10.1093/mnras/stz2517.

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ABSTRACT The GYT line list covering rotational, rovibrational, and rovibronic transitions of the mercapto radical SH is presented. This work extends and replaces the SNaSH line list, which covers the ground (electronic) X 2Π state only. This extension is prompted by the tentative identification of the ultraviolet features of SH as being of importance in the transmission spectrum of the ultrahot Jupiter exoplanet WASP-121b. This GYT line list model is generated by fitting empirical potential energy, spin–orbit, and electronic angular momenta functions to experimentally measured wavelengths with

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Moyano-López, Claudia, Luna Bridgeman, Cristina Juan, and Ana Juan-García. "Cytotoxic Profiles of Beauvericin, Citrinin, Moniliformin, and Patulin and Their Binary Combinations: A Literature-Based Comparison and Experimental Validation in SH-SY5Y Cells." Toxins 17, no. 3 (2025): 143. https://doi.org/10.3390/toxins17030143.

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Mycotoxins are toxic compounds found in food and feed that pose significant risks to human and animal health. This work reviews recent studies on the cytotoxic effects of four mycotoxins: beauvericin (BEA), citrinin (CTN), moniliformin (MON), and patulin (PAT) in various cell lines. Additionally, an experimental study evaluates the effects of these mycotoxins and their binary combinations on human neuroblastoma cells (SH-SY5Y) after 24 and 48 h of exposure using the 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) assay. This analysis is driven by the additional risks posed b

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Knippertz, Peter, Heini Wernli, and Gregor Gläser. "A Global Climatology of Tropical Moisture Exports." Journal of Climate 26, no. 10 (2013): 3031–45. http://dx.doi.org/10.1175/jcli-d-12-00401.1.

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Abstract In a recent paper, a climatology of tropical moisture exports (TMEs) to the Northern Hemisphere (NH) was constructed on the basis of 7-day forward trajectories, started daily from the tropical lower troposphere, which were required to reach a water vapor flux of at least 100 g kg−1 m s−1 somewhere north of 35°N. It was shown that TMEs contribute significantly to regional precipitation. Here, the authors complement and extend this work by (i) using 6-hourly European Centre for Medium-Range Weather Forecasts (ECMWF) Interim Re-Analysis (ERA-Interim) data from 1979 to 2010 instead of the

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Xiang, Haipan, Yunpeng Lu, Hongwei Song, and Minghui Yang. "Mode-specific quantum dynamics study of OH + H₂S → H₂O + SH reaction." Chinese Journal of Chemical Physics 35, no. 1 (2022): 200–206. http://dx.doi.org/10.1063/1674-0068/cjcp2112278.

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The hydrogen abstraction reaction from H2S by OH is of key importance in understanding of the causes of acid rain, air pollution, and climate change. In this work, the reaction OH+H2S → H2O+SH is investigated on a recently developed ab initio-based globally accurate potential energy surface by the time-dependent wave packet approach under a reduced-dimensional model. This reaction behaves like a barrier-less reaction at low collision energies and like an activated reaction with a well-defined barrier at high collision energies. Exciting either the symmetric or antisymmetric stretching mode of

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Т.Ж., Акпанова, та Рахыпбеков Т.К. "ОПЫТ СТРАН ПО ВНЕДРЕНИЮ ПРИНЦИПОВ «ЕДИНОЕ ЗДОРОВЬЕ». СРАВНИТЕЛЬНЫЙ ОБЗОР." Наука и здравоохранение, № 1(25) (28 лютого 2023): 50–58. http://dx.doi.org/10.34689/sh.2023.25.1.006.

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Актуальность: Глобальные последствия пандемии COVID-19 подчеркивают сегодня важность концепции «Единое здоровье» для системы здравоохранения, предусматривающей применение скоординированного, совместного, междисциплинарного и межсекторального подхода для устранения потенциальных или существующих рисков, возникающих на стыке «окружающая среда-животное-человек-экосистемы». Целью работы является изучение опыта стран по внедрению концепции «Единое здоровье». Стратегия поиска: сравнительный анализ публикаций по теме исследования, источников индексируемых в базах данных электронной библиотеки e-Libra

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Shulmeister, J., D. T. Rodbell, M. K. Gagan, and G. O. Seltzer. "Inter-hemispheric linkages in climate change: paleo-perspectives for future climate change." Climate of the Past Discussions 2, no. 1 (2006): 79–122. http://dx.doi.org/10.5194/cpd-2-79-2006.

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Abstract. The Pole-Equator-Pole (PEP) projects of the PANASH (Paleoclimates of the Northern and Southern Hemisphere) programme have significantly advanced our understanding of past climate change on a global basis and helped to integrate paleo-science across regions and research disciplines. PANASH science allows us to constrain predictions for future climate change and to contribute to the management and mitigation of such changes. We identify three broad areas where PEP science makes key contributions. 1. The patterns of global changes: Knowing the exact timing of glacial advances (synchrono

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Shulmeister, J., D. T. Rodbell, M. K. Gagan, and G. O. Seltzer. "Inter-hemispheric linkages in climate change: paleo-perspectives for future climate change." Climate of the Past 2, no. 2 (2006): 167–85. http://dx.doi.org/10.5194/cp-2-167-2006.

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Abstract. The Pole-Equator-Pole (PEP) projects of the PANASH (Paleoclimates of the Northern and Southern Hemisphere) programme have significantly advanced our understanding of past climate change on a global basis and helped to integrate paleo-science across regions and research disciplines. PANASH science allows us to constrain predictions for future climate change and to contribute to the management of consequent environmental changes. We identify three broad areas where PEP science makes key contributions. 1. The pattern of global changes. Knowing the exact timing of glacial advances (synch

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Hamdamova, Shamshoda Saidakhmat kizi Nasimova Mukhlisa Narzullo kizi. "LITERARY INTERPRETATION OF MOTHER-CHILD RELATIONSHIP IN UZBEK LITERATURE." MODELS AND METHODS IN MODERN SCIENCE 1, no. 14 (2022): 52–55. https://doi.org/10.5281/zenodo.7115629.

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This article gives informations  about the interpretation of one of the human relationships, the relationship between mothers and children, in Uzbek literature. The importance of mothers in upbringing children, morality and finding; their place in life is revealed by the example of the heroes of the artistic work. The character of the children who lost their mother's life due to their wrongdoing is "Ufq"(“Horizon”), "Oftoboyim" by Said Ahmad, "Qorako’z Majnun", in the works of  O'tkir Hashimov's “Urushning so’ngg

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Narinesingh, Veeshan, James F. Booth, Spencer K. Clark, and Yi Ming. "Atmospheric blocking in an aquaplanet and the impact of orography." Weather and Climate Dynamics 1, no. 2 (2020): 293–311. http://dx.doi.org/10.5194/wcd-1-293-2020.

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Abstract. Many fundamental questions remain about the roles and effects of stationary forcing on atmospheric blocking. As such, this work utilizes an idealized moist general circulation model (GCM) to investigate atmospheric blocking in terms of dynamics, geographical location, and duration. The model is first configured as an aquaplanet, then orography is added in separate integrations. Block-centered composites of wave activity fluxes and height show that blocks in the aquaplanet undergo a realistic dynamical evolution when compared to reanalysis. Blocks in the aquaplanet are also found to h

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Guillén-Watson, Rossy, Luis Barboza-Fallas, Federico Masís-Meléndez, et al. "Physicochemical and Microbial Properties of Dairy Barn Soils: A Case Study in Costa Rican Farm-Associated Soils Harboring the Foodborne Pathogen Listeria monocytogenes." Sustainability 15, no. 18 (2023): 13629. http://dx.doi.org/10.3390/su151813629.

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Animal farming activities can influence soil properties that contribute to the survival of foodborne pathogens like the ubiquitous Listeria monocytogenes. However, the presence of this pathogen in farm-associated soils in Costa Rica has not been studied, which might provide new insights regarding the environmental conditions associated with the establishment of this pathogen. In this work, we correlated the presence of L. monocytogenes with the soil physicochemical properties and bacterial community structure of soils associated with livestock activities, including a dairy barn floor (DB) and

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Avatkov, V., and Z. Rozhkova. "Change of Political System and Presidential Elections in Uzbekistan in 2023." Russia and New States of Eurasia, no. 4 (2023): 72–81. http://dx.doi.org/10.20542/2073-4786-2023-4-72-81.

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In recent years, large-scale reforms in all spheres of life have been carried out in the Republic of Uzbekistan. During the reign of President Sh. Mirziyoyev, there have been noticeable changes in the political, economic and social life of the country. It is important to note that the country’s policy has become more open, which gives the people an opportunity to participate directly in the discussion of the ongoing reforms. The article analyses the role of the updated Constitution of the Republic of Uzbekistan and the early presidential elections. The reasons and relevance of the amendments t

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A.M., Messova, Pivina L.M., Ygieva D.G., et al. "ANALYSIS OF THE STAFFING AND STRUCTURE OF THE AMBULANCE SERVICE IN THE REPUBLIC OF KAZAKHSTAN." Наука и здравоохранение, no. 2(25) (April 30, 2023): 143–49. http://dx.doi.org/10.34689/sh.2023.25.2.020.

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Objectives.The ambulance service is a crucial component of any healthcare system, providing life-saving care to those in need. The problem of staffing the ambulance service today is of the most acute importance. The state of the ambulance service is now seen as a factor of national security. To study the organization of emergency medical care, a comprehensive characterization of the quality of the personnel potential of an institution and the conditions for its development is of great importance. The aim of this study is to analyze the staffing of emergency medical care in Kazakhstan. Material

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Morar, Iulia Ioana, Raluca Maria Pop, Erik Peitzner, et al. "Phytochemical Composition and Antioxidant Activity of Manuka Honey and Ohia Lehua Honey." Nutrients 17, no. 2 (2025): 276. https://doi.org/10.3390/nu17020276.

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Honey is abundant in bioactive compounds, which demonstrate considerable therapeutic effects, particularly on oxidative stress and inflammation. Objectives: This work sought to evaluate the antioxidant mechanisms of Manuka honey (MH) and Ohia Lehua honey (OLH), correlating them with phytochemical analyses in a rat model of experimentally induced inflammation. Methods: The identification of polyphenolic compounds in the extracts was carried out using HPLC-ESI MS. The extracts’ antioxidant activity was evaluated in vitro through DPPH, FRAP, H2O2, and NO scavenging assays, while in vivo assessmen

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Zhang, Hao, Yuehao Du, Jihua Tang, Guozheng Kang, and Hongchen Miao. "Circumferential SH Wave Piezoelectric Transducer System for Monitoring Corrosion-Like Defect in Large-Diameter Pipes." Sensors 20, no. 2 (2020): 460. http://dx.doi.org/10.3390/s20020460.

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The fundamental circumferential shear horizontal (CSH0) wave is of practical importance in monitoring corrosion defects in large-diameter pipes due to its virtually non-dispersive characteristics. However, so far, there have been limited CSH0 wave transducers which can be used to constitute a structural health monitoring (SHM) system for pipes. Moreover, the CSH0 wave’s capability of sizing the corrosion-like defect has not yet been confirmed by experiments. In this work, firstly, the mechanism of exciting CSH waves was analyzed. A method based on our previously developed bidirectional SH wave

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S.T., Kizatova, Dilmuradova K.R., Panibratets L.G., et al. "ON THE ROLE OF CLINICAL MENTORS IN THE CONTEMPORARY MEDICAL EDUCATION OF MEDICAL RESIDENTS." Наука и здравоохранение, no. 1(25) (February 28, 2023): 271–77. http://dx.doi.org/10.34689/sh.2023.25.1.031.

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Introduction: In modern society, the role of mentors in training young professionals is significant as they do not only transfer their own experience, but also their traditions and professional culture. The purpose of this study is to examine the importance of the mentoring role in training of resident neonatologists and their ability to apply the knowledge in effective independent medical activities of practical health care. Methods: within the premises of the perinatal centers No. 1 and No. 2 in the regional clinical hospitals, which are equipped with modern innovative technologies to provid

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Gergondey, Rachel, Camille Garcia, Christophe H. Marchand, Stephane D. Lemaire, Jean-Michel Camadro, and Françoise Auchère. "Modulation of the specific glutathionylation of mitochondrial proteins in the yeast Saccharomyces cerevisiae under basal and stress conditions." Biochemical Journal 474, no. 7 (2017): 1175–93. http://dx.doi.org/10.1042/bcj20160927.

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The potential biological consequences of oxidative stress and changes in glutathione levels include the oxidation of susceptible protein thiols and reversible covalent binding of glutathione to the –SH groups of proteins by S-glutathionylation. Mitochondria are central to the response to oxidative stress and redox signaling. It is therefore crucial to explore the adaptive response to changes in thiol-dependent redox status in these organelles. We optimized the purification protocol of glutathionylated proteins in the yeast Saccharomyces cerevisiae and present a detailed proteomic analysis of t

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Akynbekova, A. "Morphological Dialectisms in the Work Sanat Digarasttar by Moldo Niyaz." Bulletin of Science and Practice 6, no. 2 (2020): 334–40. http://dx.doi.org/10.33619/2414-2948/51/42.

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Moldo Niyaz is a person who has a unique place in the Kyrgyz language, literature, history and culture. He is the ancestor of the development of the form of written literary language in the nineteenth century. His work Sanat Digarasttar is of great importance as one of the priceless documents that makes it possible to reflect on the state of the language, almost in the previous century and a half and on the written monuments of the Kyrgyz language for linguistic science in the middle of the XIX century. Artistic and aesthetic value, dignity, all the beauty of Sanat songs left by the author are

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Akynbekova, A. "Morphological Dialectisms in the Work Sanat Digarasttar by Moldo Niyaz." Bulletin of Science and Practice 6, no. 2 (2020): 334–40. https://doi.org/10.33619/2414-2948/51/42.

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Moldo Niyaz is a person who has a unique place in the Kyrgyz language, literature, history and culture.  He is the ancestor of the development of the form of written literary language in the nineteenth century. His work Sanat Digarasttar is of great importance as one of the priceless documents that make it possible to reflect on the state of the language, almost in the previous century and a half and on the written monuments of the Kyrgyz language for linguistic science in the middle of the XIX century. Artistic and aesthetic value, dignity, all the beauty of Sanat songs left by the autho

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Г.Р., Даутбаева. "РАЗРАБОТКА ЭФФЕКТИВНЫХ МЕТОДОВ СОДЕЙСТВИЯ ТРУДОУСТРОЙСТВУ ВЫПУСКНИКОВ МЕДИЦИНСКОГО ВУЗА В ВОСТОЧНО-КАЗАХСТАНСКОЙ ОБЛАСТИ". Наука и здравоохранение, № 2(17) (30 квітня 2015): 103–12. http://dx.doi.org/10.34689/sh.2015.17.2.011.

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Введение. Кадровые ресурсы играют основополагающую роль в развитии и деятельности отрасли здравоохранения, принося высокий социальный и экономический эффект. Решение проблем трудоустройства выпускников медицинских вузов зависит от региональных особенностей системы здравоохранения, уровня социальной инфраструктуры, наличия финансовой и психологической поддержки на местах, наличия системы мониторинга кадровых ресурсов. Цель. Поиск эффективного сотрудничества в области кадровой политики в системе здравоохранения и обеспечения отрасли квалифицированными кадрами, разработки наиболее действенных мет

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Glasco, Dalton Lee, and Jeffrey Gordon Bell. "Nonlinear Behavior during the Electrochemical Oxidation of Thiols." ECS Meeting Abstracts MA2022-01, no. 45 (2022): 1928. http://dx.doi.org/10.1149/ma2022-01451928mtgabs.

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The electrochemical behavior of sulfur-containing compounds is of great importance in fields ranging from diagnostics to energy-storage and materials chemistry. For example, thiols (R-SH) are important components of many electrochemical sensors and are routinely used in materials applications as they are known to form well-ordered and reproducible monolayers (self-assembled monolayers, SAMs) on various metal surfaces. Sulfur compounds are also interesting from the viewpoint of nonlinear dynamics owing to the presence of multiple oxidation states, which has been exploited to study complex dynam

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Sweeney, Eileen Mac, Ilaria Chiocchio, Manuela Mandrone, et al. "Exploring the Anti-Inflammatory and Antioxidant Potential, Metabolite Composition and Inorganic Profile of Cistus monspeliensis L. Aerial Parts and Roots." Antioxidants 13, no. 7 (2024): 753. http://dx.doi.org/10.3390/antiox13070753.

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This work focuses on Cistus monspeliensis L. aerial parts (AP) and roots (R) extracts, investigating the anti-inflammatory and antioxidant potential of the two organs in comparison. At dosages between 1.56 and 6.25 µg/mL, both extracts showed a protective effect against LPS inflammatory stimulus on a macrophage cell line (RAW 264.7). Interestingly, only R was able to significantly reduce both IL-1β and IL-6 mRNA gene expression in the presence of LPS. Moreover, the treatment of a neuroblastoma cell line (SH-SY5Y) with AP and R at 6.25 µg/mL increased the cell survival rate by nearly 20% after

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Kembayeva, A. T., and O. S. Zhubai. "Relevance and Scope of Application of the Concept «Spirit» in the Field of Linguistic Personality (based on the work of Sh. Murtaza)." Iasaýı ýnıversıtetіnіń habarshysy 132, no. 2 (2024): 167–79. http://dx.doi.org/10.47526/2024-2/2664-0686.52.

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Currently, the scientific direction of conceptuology is one of the most studied topics in Kazakh linguistics, like linguoculturology, anthropocentric linguistics. The main research goals of these three areas are very similar because in all these moments language is closely connected with the human factor. This article examines the concept of «Spirit» in the works of the outstanding Kazakh writer and public figure Sherkhan Murtaza. The author demonstrates the versatility of this concept and its significance in his work. The aim of the article is to analyse how the concept of «Spirit» takes on d

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K., Inoue, Fukunaga T., Apbassova M., et al. "CHANGES IN THE CONTEXT OF SUICIDES AMONG STUDENTS IN METROPOLIS OF JAPAN DURING THE COVID-19 PANDEMIC: SUCH DISCUSSION WOULD BE NECESSARY IN THE REPUBLIC OF KAZAKHSTAN AND EACH CITY." Наука и здравоохранение, no. 4(25) (August 31, 2023): 7–12. http://dx.doi.org/10.34689/sh.2023.25.4.001.

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Background: Many individuals reported the feeling of 'reaching their breaking point' due to the COVID-19 pandemic's continued restrictions in their daily lives. In Japan, students at all levels have been significantly affected since the spring of 2020 by COVID-19-based restrictions on school attendance, the shift to online courses, and a reduced demand for part-time work, resulting in students' mental and physical exhaustion. Objective: The current prevalence of suicide among students should thus be promptly ascertained. It is important to discuss the necessity of such consideration in the Rep

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Rivero-Rodriguez, Javier, and Benoit Scheid. "Mass transfer around bubbles flowing in cylindrical microchannels." Journal of Fluid Mechanics 869 (April 23, 2019): 110–42. http://dx.doi.org/10.1017/jfm.2019.136.

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This work focuses on the mass transfer around unconfined bubbles in cylindrical microchannels when they are arranged in a train. We characterise how the mass transfer, quantified by the Sherwood number, $Sh$, is affected by the channel and bubble sizes, distance between bubbles, diffusivity, mean flow velocity, deformation of the bubble, the presence of surfactants in the limit of rigid interface and off-centred positions of the bubbles. We analyse the influence of the dimensionless numbers and especially the distance between bubbles and the Péclet number, $Pe$, which we vary over eight decade

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Gamal, Hossam A. M., Taghreed M. Zewail, and El-Sayed Z. El-Ashtoukhy. "Effect of crude oil on the rate of diffusion-controlled corrosion in pipelines under turbulent flow conditions." Corrosion Reviews 36, no. 5 (2018): 483–93. http://dx.doi.org/10.1515/corrrev-2017-0084.

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AbstractThe present work aimed to investigate the effect of crude oil on the rate of diffusion-controlled corrosion of copper pipeline in acidified dichromate under fully developed flow. To achieve this goal, various parameters were investigated, such as crude oil percentage volume (%), flow physical properties, active height of the copper pipeline, flow velocity, and the presence of Triton X-100. The results of our study revealed that the rate of copper pipeline inner-wall corrosion increases with the increase of crude oil percentage volume and flow velocity. On the other hand, the active hei

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D.K., Kussainova, Khismetova Z.A., and Assanova Sh.B. "PSYCHOEMOTIONAL STATE OF MEDICAL WORKERS DURING THE COVID-19 PANDEMIC." Наука и здравоохранение, no. 6(23) (February 1, 2022): 47–53. http://dx.doi.org/10.34689/sh.2021.23.6.005.

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Introduction. Medical workers need to cope with a number of serious problems, ranging from an increased risk of death in medical institutions and at home, an increase in working hours and physical and psychological stress at work, as well as solving difficult situations arising from contact with members of the public and social isolation from colleagues and loved ones. The physical and psychological impact of working during the COVID-19 pandemic was significant: thousands of medical workers worldwide died from SARSCoV-2 infection, and some even committed suicide. It is important to note that h

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Cerri, Silvia, Cristina Ghezzi, Gerardo Ongari, et al. "GBA Mutations Influence the Release and Pathological Effects of Small Extracellular Vesicles from Fibroblasts of Patients with Parkinson’s Disease." International Journal of Molecular Sciences 22, no. 4 (2021): 2215. http://dx.doi.org/10.3390/ijms22042215.

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Heterozygous mutations in the GBA gene, encoding the lysosomal enzyme glucocerebrosidase (GCase), are the strongest known genetic risk factor for Parkinson’s disease (PD). The molecular mechanisms underlying the increased PD risk and the variable phenotypes observed in carriers of different GBA mutations are not yet fully elucidated. Extracellular vesicles (EVs) have gained increasing importance in neurodegenerative diseases since they can vehiculate pathological molecules potentially promoting disease propagation. Accumulating evidence showed that perturbations of the endosomal–lysosomal path

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Silva, Rui, Ana Cristina Carvalho, David Carvalho, and Alfredo Rocha. "Study of Urban Heat Islands Using Different Urban Canopy Models and Identification Methods." Atmosphere 12, no. 4 (2021): 521. http://dx.doi.org/10.3390/atmos12040521.

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This work aims to compare the performance of the single‑(SLUCM) and multilayer (BEP-Building effect parameterization) urban canopy models (UCMs) coupled with the Weather Research and Forecasting model (WRF), along with the application of two urban heat island (UHI) identification methods. The identification methods are: (1) the “classic method”, based on the temperature difference between urban and rural areas; (2) the “local method” based on the temperature difference at each urban location when the model land use is considered urban, and when it is replaced by the dominant rural land use cat

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Қуандық, Ұ. Е., та А. О. Омарова. "ЖАЛПЫ ОРТА БІЛІМ БЕРУ МЕКЕМЕЛЕРІ ЖАҒДАЙЫНДА ОҚУШЫЛАРДЫҢ ГИГИЕНАЛЫҚ МӘДЕНИЕТІ. ӘДЕБИЕТКЕ ШОЛУ." Наука и здравоохранение, № 6(26) (30 грудня 2024): 196–210. https://doi.org/10.34689/sh.2024.26.6.022.

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Кіріспе. Мектеп оқушыларының тиісті гигиеналық білімдері мен дағдылары балалар арасында жұқпалы аурулардың деңгейін төмендету үшін өте маңызды. Дүниежүзілік денсаулық сақтау ұйымының мәліметтері бойынша, балалар ересектермен салыстырғанда қауіп факторларына осал, осы осалдыққа байланысты мектептерде тиісті сумен жабдықтау, санитария және гигиена қызметтерінің болуы ерекше маңызға ие. Мектеп ортасындағы су, санитария және гигиена қызметтерінің жеткіліксіздігі денсаулық сақтау және білім беру нәтижелеріне тікелей немесе жанама әсер етеді. Мектептер су, санитария және гигиенаға қатысты білім мен

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de Matos, Ana M., Alice Martins, Teresa Man та ін. "Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H2O2- and Aβ1-42-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells". Pharmaceuticals 12, № 2 (2019): 98. http://dx.doi.org/10.3390/ph12020098.

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With the lack of available drugs able to prevent the progression of Alzheimer’s disease (AD), the discovery of new neuroprotective treatments able to rescue neurons from cell injury is presently a matter of extreme importance and urgency. Here, we were inspired by the widely reported potential of natural flavonoids to build a library of novel flavones, chromen-4-ones and their C-glucosyl derivatives, and to explore their ability as neuroprotective agents with suitable pharmacokinetic profiles. All compounds were firstly evaluated in a parallel artificial membrane permeability assay (PAMPA) to

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Espinosa-Bustos, Christian, Luisa Leitzbach, Tito Añazco, et al. "Substituted Purines as High-Affinity Histamine H3 Receptor Ligands." Pharmaceuticals 15, no. 5 (2022): 573. http://dx.doi.org/10.3390/ph15050573.

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Continuing with our program to obtain new histamine H3 receptor (H3R) ligands, in this work we present the synthesis, H3R affinity and in silico studies of a series of eight new synthetically accessible purine derivatives. These compounds are designed from the isosteric replacement of the scaffold presented in our previous ligand, pyrrolo[2,3-d]pyrimidine ring, by a purine core. This design also considers maintaining the fragment of bipiperidine at C-4 and aromatic rings with electron-withdrawing groups at N-9, as these fragments are part of the proposed pharmacophore. The in vitro screening r

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Pashko, Oksana. "“...Sered Skytiv-Chynbariv”: Approach to the Symbolism of Shoes in Viktor Petrov-Domontovych’s Works." NaUKMA Research Papers. Literary Studies 3 (September 2, 2022): 53–67. http://dx.doi.org/10.18523/2618-0537.2022.3.53-67.

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The article proves the importance of the philosophy of things, clothes/shoes in the literary works, scientific article, and memoirs of Viktor Petrov-Domontovych. This theme is analyzed in the context of the philosophy of clothing of Tomas Carlyle and Barbe d`Oréville. An analysis of works “The Girl with the Bear,” “Doctor Seraficus,” “Alina and Kostomarov,” and the article “Petersburg Tales of Gogol” shows that in Viktor Petrov`s works there is a complex of motives: eccentric – saint – traveler – man – villain – boots/shoes (thing) – gait – poetry. Observations of the dynamics of images in eac

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Li, Yang, Zhijin Huang, Zhan Sui, et al. "Optical anapole mode in nanostructured lithium niobate for enhancing second harmonic generation." Nanophotonics 9, no. 11 (2020): 3575–85. http://dx.doi.org/10.1515/nanoph-2020-0222.

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AbstractSecond harmonic generation (SHG) with a material of large transparency is an attractive way of generating coherent light sources at exotic wavelength range such as VUV, UV and visible light. It is of critical importance to improve nonlinear conversion efficiency in order to find practical applications in quantum light source and high resolution nonlinear microscopy, etc. Here an enhanced SHG with conversion efficiency up to 10−2% at SH wavelength of 282.7 nm under 11 GW/cm2 pump intensity via the excitation of anapole in lithium niobite (LiNbO3, or LN) nanodisk through the dominating d

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А.М., Маркабаева, Керимкулова А.С., Нурпейсова Р.Г., Жуманбаева Ж.М. та Мухамеджанова А.А. "ҚАЗАҚСТАН РЕСПУБЛИКАСЫНДА 2015-2020 ЖЫЛДАР АРАЛЫҒЫНДА ЖҮРЕК-ТАМЫР АУРУЛАРЫНЫҢ ТАРАЛУЫ". Наука и здравоохранение, № 5(25) (31 жовтня 2023): 70–77. http://dx.doi.org/10.34689/sh.2023.25.5.009.

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Кіріспе: Қазақстан Республикасында халықтың аурушаңдылығы мен өлім-жітімнің жалпы құрылымында қан айналым жүйесінің аурулары жетекші орын алады. Қан айналым жүйесі ауруларының ішінде жүрек ишемиялық ауруы, артериялық гипертензия, мидың тамырлық зақымдануы жиі кездеседі. Зерттеудің мақсаты: Қазақстан Республикасында 2015-2020 жылдар аралығында қан айналым жүйесі және оның ішінде жүректің ишемиялық ауруы мен артериялық гипертензиядан сырқаттылық және өлім-жітім көрсеткіштерінің динамикасын бағалау. Материалдар мен әдістері: қан айналым жүйесінің аурулары және оның ішінде жүректің ишемиялық ауруы

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Yu, De, Shougeng Hu, Luyi Tong, Cong Xia, and Penglai Ran. "Dynamics and Determinants of the Grain Yield Gap in Major Grain-Producing Areas: A Case Study in Hunan Province, China." Foods 11, no. 8 (2022): 1122. http://dx.doi.org/10.3390/foods11081122.

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Understanding the dynamics of the grain yield gap (YGAP) and its causative factors is essential for optimizing the layout of grain production and addressing the food crisis, especially in countries with a huge population and less cultivated land, such as China. In the study, a spatial analysis- and machine learning-based framework for YGAP analysis was developed, taking Hunan Province, China, as an application. The results showed that the average YGAP in Hunan Province gradually narrowed from 1990 to 2018, and the YGAPs narrowed in 116 counties. Of which, 26 counties narrowed by more than 4 t

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Grebennikova, N. V. "Value-semantic component of the psychological and pedagogical culture of the personality of students from psychological and pedagogical classes." Vestnik Universiteta, no. 3 (May 14, 2025): 273–82. https://doi.org/10.26425/1816-4277-2025-3-273-282.

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The article analyses the importance of creating psychological and pedagogical classes and describes their main goals. One of the results of the functioning of psychological and pedagogical classes is the development of psychological and pedagogical culture, which is identified within the framework of pedagogical science. The researchers defined it as the psychological culture of the teacher, but the expansion of understanding and the transition to educational psychology will allow for the inclusion of research and work on the development of the psychological and pedagogical culture of high sch

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Alsharief, Ahmed Faraj Alarbi, Xili Duan, and Yuri S. Muzychka. "Evolution of Air Plastron Thickness and Slip Length over Superhydrophobic Surfaces in Taylor Couette Flows." Fluids 8, no. 4 (2023): 133. http://dx.doi.org/10.3390/fluids8040133.

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Drag reduction (DR) using superhydrophobic surfaces (SHSs) has received intensive interest due to the emergence of SH coating technology. The air layer (plastron “δ”) trapped between the SHS and the water controls the flow slip over the SHSs. We demonstrate slippage over three fabricated SHSs in laminar and low turbulent Taylor–Couette flows. We experimentally investigate how the slip length increases with a higher Reynolds number (Re) over the tested SHSs; simultaneously, the air plastron thickness investigates using a viscous model. The mean skin friction coefficient (Cf) can be fitted to a

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S.K., Ramazanov, Shevchenko A.I., and Kuptsova E.A. "Artificial intelligence and problems of intellectualization: development strategy, structure, methodology, principles and problems." Artificial Intelligence 25, no. 4 (2020): 14–23. http://dx.doi.org/10.15407/jai2020.04.014.

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The paper analysis the strategies and concepts developed in the world in modern directions: innova- tive economy, digital economy, artificial intelligence, Industry 4.0 and others. The problem is to determine the initial fundamental parameters of order and their prospects in the global world, the definition and principles of artificial intel- ligence systems (AIS), its structure and important aspects and principles of future science and technology in analysis and synthesis based on synergetic approaches, innovative, information, converged technologies, taking into account the design of future

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Artemyeva, Tamara V., and Oleg I. Pechnikov. "On the Issue of Teaching Creative Writing to the Primary School Students." Development of education 4, no. 3 (2021): 15–20. http://dx.doi.org/10.31483/r-99423.

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The purpose of the article is to determine the importance of teaching creative writing to younger schoolchildren. The urgency of the problem of teaching creative writing in the native Chuvash language is due to the need for the formation of text competencies in younger schoolchildren, the lack of formation of their native writing skills, especially creative writing. Material and methods of research. The main research methods were the study of literature, the analysis of teachers 'difficulties and errors in the students' works. A brief history of the issue is considered: the ideas of developing

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Baeshova, B. Sh. "The Specifics of the Study of Small Stanzas in Kazakh Poetry." Iasaýı ýnıversıtetіnіń habarshysy 131, no. 1 (2024): 20–29. http://dx.doi.org/10.47526/2024-1/2664-0686.02.

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The article is devoted to the study of the genesis and features of the development of “kara olen” (poem), an ancient genre of Kazakh literature. We are talking about the environment of chanting, the area of distribution of “kara olen”, which conveys the way of life, culture and literature of the Kazakh people. The opinions of scientists on the nature and definition of the genre are considered. It is known that "Kara olen" was studied by Sh. Ualikhanov, M. Auyezov, K. Zhumaliev, E. Ismailov, B. Kenzhebaev, B. Uakatov, Z. Akhmetov, G. Doskenov and other famous scientists. Examples from the state

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Authiat, Marcella M., Emmanuelle Gruz-Gibelli, Julien Colas, et al. "Preferential Involvement of BRCA1/BARD1, Not Tip60/Fe65, in DNA Double-Strand Break Repair in Presenilin-1 P117L Alzheimer Models." Neural Plasticity 2022 (February 21, 2022): 1–18. http://dx.doi.org/10.1155/2022/3172861.

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Recently, we showed that DNA double-strand breaks (DSBs) are increased by the Aβ42-amyloid peptide and decreased by all-trans retinoic acid (RA) in SH-SY5Y cells and C57BL/6J mice. The present work was aimed at investigating DSBs in cells and murine models of Alzheimer’s disease carrying the preseniline-1 (PS1) P117L mutation. We observed that DSBs could hardly decrease following RA treatment in the mutated cells compared to the wild-type cells. The activation of the amyloidogenic pathway is proposed in the former case as Aβ42- and RA-dependent DSBs changes were reproduced by an α-secretase an

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Vavilin, Mikhail Vladimirovich. "The Activities of the Prosecution to Ensure the Rule of Law in the Implementation of State Policy in the Field of Patriotic Education of Young People: Relevance and Problems." Russian Journal of Legal Studies 6, no. 1 (2019): 159–66. http://dx.doi.org/10.17816/rjls18489.

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Today the issue of Patriotic education of citizens is very important. Part 2 of аrticle 13 of the Constitution of the Russian Federation prohibits to establish any state ideology. To solve this problem in this article, the author bases his conclusions on the theory of “constitutional patriotism” by Jurgen Habermas. The Constitution of the Russian Federation already contains Patriotic norms, fulfilling which a citizen can be called a real patriot. These are articles of the Constitution of the Russian Federation about State symbols of the Russian Federation (part1 of article 70), about the prese

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Azmaiparashvili, Maia. "ASPECTS OF SUSTAINABLE DEVELOPMENT OF ECOLOGICAL TOURISM IN THE PROTECTED AREAS OF GEORGIA." Innovative economics and management 11, no. 3 (2024): 35–46. https://doi.org/10.46361/2449-2604.11.3.2024.35-46.

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Maia Azmaiparashvili E-mail: maiaazmaiparashvili@gmail.com Doctor of Ecology, Associate Professor , Gori State University Gori, Georgia https://orcid.org/0000-0002-7868-5463 Abstract: The most important natural factor in the development of tourism is the protected areas. Together with the natural wealth of the country, the protected areas preserve the memory of the historical and cultural heritage. Tourism should become a guarantee not only of economic strength, but also of environmental protection. The strength of properly managed tourism is to create a limit for the sustainable development o

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Anet, J. G., S. Muthers, E. V. Rozanov, et al. "Impact of solar versus volcanic activity variations on tropospheric temperatures and precipitation during the Dalton Minimum." Climate of the Past 10, no. 3 (2014): 921–38. http://dx.doi.org/10.5194/cp-10-921-2014.

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Abstract. The aim of this work is to elucidate the impact of changes in solar irradiance and energetic particles versus volcanic eruptions on tropospheric global climate during the Dalton Minimum (DM, AD 1780–1840). Separate variations in the (i) solar irradiance in the UV-C with wavelengths λ < 250 nm, (ii) irradiance at wavelengths λ > 250 nm, (iii) in energetic particle spectrum, and (iv) volcanic aerosol forcing were analyzed separately, and (v) in combination, by means of small ensemble calculations using a coupled atmosphere–ocean chemistry–climate model. Global and hemispheric mea

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Romasheva, Zhanagul Zh, Olga V. Kalinichenko, and Ivan V. Malyshev. "Connection between basic values and emigration attitudes of Russian youth." Izvestiya of Saratov University. Educational Acmeology. Developmental Psychology 10, no. 4 (2021): 323–33. http://dx.doi.org/10.18500/2304-9790-2021-10-4-323-333.

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The ambiguity and inconsistency of the data on the connection between emigration attitudes and metavalues spurs the research on the relation between emigration attitudes and basic values. Hence, the problem of studying the deterministic character of youth attitudes to emigration is seen as of relevance. The purpose of this research is to determine the nature of the connection between basic values and emigration attitudes. Hypotheses: 1. The basic values that make up metavalues act as the predictors of emigration attitudes. 2. The basic values constituting the contrastive metavalues of Preserva

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