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Dissertations / Theses on the topic 'The N-end rule'

Author: Grafiati

Published: 7 July 2024

Last updated: 31 July 2025

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1

Wang, Kevin H. Ph D. Massachusetts Institute of Technology. "Tuning strength and specificity in the N-end rule." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/45808.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2008.<br>Title of thesis missing on title page; supplied from the abstract, p. [1].<br>Includes bibliographical references (p. 107-115).<br>Protein degradation is a central mechanism in the regulation of gene expression and activity. Proteolysis regulates not only homeostatic activities, but also the cell's responses to stress. A recurring question underlying this regulatory process is the specificity of substrate selection by the proteolytic machinery. I designed an unbiased selection to isolate N-terminal degradation s

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2

Stein, Benjamin J. (Benjamin Joseph). "Substrate specificity of [alpha]-proteobacterial N-end rule adaptors." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/104102.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2016.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student-submitted PDF version of thesis. "June 2016." In title on title page [alpha] appears as lower case Greek letters.<br>Includes bibliographical references (pages 103-118).<br>by Benjamin J. Stein.<br>Ph. D.

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3

Woollard, Geoffrey Robert Paget. "Redesign of the N-end rule protein ClpS for use in high-throughput N-end protein sequencing." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/46377.

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Current protein sequencing methods include mass spectrometry and Edman degradation. We envision a novel high-throughput protein sequencing method using affinity adapters to recognize the N-terminal residue of a denatured peptide in an iterative process. This thesis takes a first step toward designing robust and selective affinity reagents. We outline our pipeline for designing selective protein adapters that recognize the N-terminal amino acid of a peptide independent of the following sequence. We based our design on a substrate recognition protein in the N-end rule pathway, ClpS. The bacteria

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4

Jones, Peter Dafydd. "The function of the N-end rule pathway in Arabidopsis seed germination." Thesis, University of Nottingham, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.546566.

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5

Tremblay, Alexandre. "Une approche afin de produire les différentes conformations de caspase-7 tout en contrôlant l'induction de l'apoptose." Mémoire, Université de Sherbrooke, 2011. http://savoirs.usherbrooke.ca/handle/11143/4081.

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Caspase-7 is a member of a family of cysteine proteases that includes apoptotic initiators (caspases-8, -9 and -10) and executors (caspases-3, -6 and -7). During apoptosis, executioner caspases are cleaved by initiator caspases either by the extrinsic (death receptors) or by the intrinsic (mitochondrial) pathway of caspase activation. Caspase-7 is an obligate dimer in the cell and cleavage of the interdomain connector (IDC), which split the catalytic domain in two subunits, at either site 1 or site 2 allows the conversion of the enzyme from the zymogen (inactive) state to the active state thro

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6

Dissmeyer, Nico [Verfasser]. "Protein recognition and degradation via the N-end rule pathway : [kumulative Habilitation] / Nico Dissmeyer." Halle, 2018. http://d-nb.info/1168627575/34.

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7

Faden, Frederik [Verfasser]. "A simple technique for N-end rule-controlled conditional protein accumulation in vivo / Frederik Faden." Halle, 2017. http://d-nb.info/1138641855/34.

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8

Naumann, Christin [Verfasser]. "Identifizierung und Charakterisierung neuer Substrate des N-end rule pathways in Arabidopsis thaliana / Christin Naumann." Halle, 2017. http://d-nb.info/113349224X/34.

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9

Rooney, D. J. "An investigation into the mechanism and function of cysteine oxidation in the plant N-end rule pathway." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/39348/.

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Flooding events are becoming more common throughout the world as a result of climate change, resulting in reduced crop yields. It was recently discovered that plants sense low oxygen (O2) (associated with flooding) through regulated proteolysis of the group VII Ethylene Response Factor transcription factors (ERFVIIs), via the Cys-Arg/N-end rule pathway of ubiquitin mediated proteolysis, which also senses another gas, nitric oxide (NO). The N-terminal (Nt) Cys of physiological (e.g. ERFVIIs) and artificial substrates was shown to be key for N-end rule function, and work in mammalian systems sug

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10

Wang, Xu. "The role of ethylene and the N-end rule pathway in the regulation of Arabidopsis seed dormancy." Electronic Thesis or Diss., Sorbonne université, 2019. http://www.theses.fr/2019SORUS421.

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L'éthylène comme la stratification au froid et le GA3, stimule la germination des graines d'Arabidopsis thaliana (Col-0) ayant une dormance primaire, à 25 °C et à l'obscurité. L'élimination de la dormance au froid n'exige pas ETR1, EIN4 et EIN2, alors que l'effet du GA3 nécessite ETR1. L'effet stimulateur de l'éthylène est associé à une réduction de l'expression des gènes impliqués dans les voies de signalisation des GAs (DELLAs) et de l'ABA (ABI5). Les graines du mutant prt6 affectées dans la voie "N-end rule" de la protéolyse, sont insensibles à l'éthylène, montrant que PRT6 intervient dans

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11

Ying, Shiyu. "Régulation et rôle des facteurs de transcription de type ERF de la sous-classe E (ERF-E) dans la maturation des fruits climactériques." Electronic Thesis or Diss., Toulouse, INPT, 2023. http://www.theses.fr/2023INPT0141.

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Le mûrissement des tomates est un processus finement régulé avec de nombreux changements dynamiques qui concernent les voies du métabolisme primaire et secondaire, la respiration ou encore la signalisation hormonale. Comme les autres fruits climactérique, la tomate connait une transition développementale du stade « pré-maturation » à la phase de maturation qui est associée à une augmentation de la respiration au début de la maturation et à une augmentation de la production autocatalytique d'éthylène. Les facteur de réponse à l'éthylène, de la sous-clade E (ERF.E), ont un profil d'expression fo

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12

Román, Hernández Giselle. "The N-end rule degradation pathway : substrate recognition and staged delivery to the CIpAP protease by the CIpS adaptor protein." Thesis, Massachusetts Institute of Technology, 2011. http://hdl.handle.net/1721.1/65296.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, June 2011.<br>"June 2011." Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 158-165).<br>Regulated protein degradation is crucial in the regulation of many physiological processes as well as in protein quality control. In all organisms, ranging from bacteria to mammals, ATP-dependent proteases carry out regulated protein degradation in order to maintain homeostasis as well as to respond to stress. ATP-dependent proteases are responsible for the degradation of a broad array of substrates an

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13

Klecker, Maria [Verfasser], Ingo [Gutachter] Heilmann, Nico [Gutachter] Dissmeyer, and Frederica [Gutachter] Theodoulou. "The substrate specificity of N-end rule components from Arabidopsis thaliana / Maria Klecker ; Gutachter: Ingo Heilmann, Nico Dissmeyer, Frederica Theodoulou." Halle (Saale) : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2019. http://d-nb.info/1210729490/34.

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14

Lamichhane, Suman. "Physiological and Molecular Dissection of Salinity Tolerance in Arabidopsis and Maize and Nitrogen Uptake in Wheat." Diss., Virginia Tech, 2020. http://hdl.handle.net/10919/97843.

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The PROTEOLYSIS 6 (PRT6) branch of the N-end rule pathway is a well-characterized negative regulator of flooding and low oxygen tolerance in plants. This study investigated the role of this pathway in adaptation to salinity stress in Arabidopsis and maize via physiological and molecular characterization of Arabidopsis prt6-1 and maize prt6 MU insertion mutants, respectively. Our study demonstrated that the loss of function mutation of prt6 in Arabidopsis activated hormonal and transcriptional responses associated with adaptation to salinity stress, enhancing high salt tolerance at seed germina

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15

Costa, Broseta Álvaro. "Regulation of the nitric oxide synthesis and signaling by posttranslational modifications and N-end rule pathway-mediated proteolysis in Arabidopsis thaliana." Doctoral thesis, Universitat Politècnica de València, 2019. http://hdl.handle.net/10251/114825.

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El óxido nítrico (NO) es una molécula gaseosa altamente reactiva que regula el crecimiento y el desarrollo de las plantas así como sus respuestas de defensa. El NO se produce principalmente a partir de nitrito por las nitrato reductasas (NRs) en balance con las nitrito reductasas (NiRs), y es percibido a través de un mecanismo en el que está involucrada la proteólisis dirigida por la secuencia aminoterminal del grupo VII de los factores de transcripción ERF (ERFVIIs). El NO ejerce especialmente su función señalizadora al causar modificaciones postraduccionales en las proteínas y alterar su fun

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16

Prasad, Geeta. "To investigate the relationship between substrates of the N-end rule pathway and genes regulated by 'GCCGCC' cis-elements in Arabidopsis thaliana." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/33082/.

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The N-end rule pathway of targeted proteolysis is regulated by Group VII ethylene response factors (ERFVII’s). The aim of this research work was to analyse the relationship between substrates (ERFVII’s) of the N-end rule pathway and genes, which have promoters containing a double ‘GCCGCC’ Ethylene-Responsive Element Binding Protein (EBP) cis-element. Several genes were identified containing double EBP elements. Cloning and transformation of the promoters from five of these genes (PYL, ERD4, AT1G14810, AT3G13440 and AT5G44420) carrying two copies of the GCC-boxes present in the 5' UTR (5’ untra

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17

Su, Xinyi. "A vertebrate N-end rule conditional protein degradation system and its use in temporal dissection of DNA transactions in a single cell cycle." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612541.

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18

Apitz, Janina. "Charakterisierung von Arabidopsis HEMA-Mutanten und in vivo-Analyse funktioneller Domänen der pflanzlichen Glutamyl-tRNA-Reduktasen." Doctoral thesis, Humboldt-Universität zu Berlin, Lebenswissenschaftliche Fakultät, 2016. http://dx.doi.org/10.18452/17527.

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Die Tetrapyrrolbiosynthese (TBS) führt zu wichtigen Endprodukten wie Häm und Chlorophyll. Das gemeinsame Vorstufenmolekül aller Tetrapyrrole ist die 5-Aminolävulinsäure (ALA), die in Pflanzen über den C5-Weg aus Glutamat synthetisiert wird. Das erste spezifische Enzym der ALA-Synthese und somit auch der TBS ist die Glutamyl-tRNA Reduktase (GluTR). Sie unterliegt als Schlüsselenzym einer strengen Regulation. Aufgrund der unterschiedlichen Expression der HEMA-Gene in Arabidopsis wird ein differenzieller Beitrag der GluTR-Isoformen zu den Endprodukten der TBS vermutet. Analysen von knockout-Muta

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19

Pazo, Pelegrí Esther 1993. "New pathways regulating MBF-dependent transcription in fission yeast." Doctoral thesis, TDX (Tesis Doctorals en Xarxa), 2021. http://hdl.handle.net/10803/672476.

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At the end of G1 phase, cells have to decide between continue proliferation or remain in a quiescent state (G0). This decision point, known as “Start” in yeast and “Restriction Point” in metazoans, marks irreversibly the commitment to the completion of a new cell cycle, and is regulated mainly by the activity of the G1 CDK and the induction of the G1-to-S transcriptional program. The MBF transcription factor complex (functional homolog of pRB-E2F in metazoans) drives the G1-to-S transcriptional wave in the fission yeast Schizosaccharomyces pombe. We have previously described how the co-repress

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20

Rovere, Martina. "Étude fonctionnelle de la famille des facteurs de transcription ERF-VIIs chez Medicago truncatula : régulateurs clés de l’adaptation au manque d’oxygène." Thesis, Université Côte d'Azur (ComUE), 2018. http://www.theses.fr/2018AZUR4037/document.

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Les légumineuses sont connues pour leurs capacités à établir une relation symbiotique avec des bactéries du sol fixatrices de l'azote atmosphérique. Cette interaction aboutit à la formation d'un nouvel organe au niveau des racines, la nodosité, au sein duquel le symbiote convertit l'azote atmosphérique (N2) en ammoniac, qui peut être directement consommé par les plantes. A l’intérieur de cette nodosité, la concentration en oxygène (O2) est maintenue à un très faible niveau car la réaction de réduction du N2 par l’enzyme bactérienne nitrogénase est inhibée par des traces d’oxygène. Un mécanisme

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21

Rovere, Martina. "Étude fonctionnelle de la famille des facteurs de transcription ERF-VIIs chez Medicago truncatula : régulateurs clés de l’adaptation au manque d’oxygène." Electronic Thesis or Diss., Université Côte d'Azur (ComUE), 2018. http://www.theses.fr/2018AZUR4037.

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Les légumineuses sont connues pour leurs capacités à établir une relation symbiotique avec des bactéries du sol fixatrices de l'azote atmosphérique. Cette interaction aboutit à la formation d'un nouvel organe au niveau des racines, la nodosité, au sein duquel le symbiote convertit l'azote atmosphérique (N2) en ammoniac, qui peut être directement consommé par les plantes. A l’intérieur de cette nodosité, la concentration en oxygène (O2) est maintenue à un très faible niveau car la réaction de réduction du N2 par l’enzyme bactérienne nitrogénase est inhibée par des traces d’oxygène. Un mécanisme

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22

Shemorry, Anna. "Studies of the N-End Rule Pathway in Saccharomyces cerevisiae." Thesis, 2013. https://thesis.library.caltech.edu/7450/1/Shemorry_Anna_2013_Thesis.pdf.

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<p>Many intracellular proteins are either conditionally or constitutively short-lived, with in vivo half-lives that can be as brief as a few minutes. The regulated and processive degradation of intracellular proteins is carried out largely by the ubiquitin (Ub)-proteasome system (UPS). In eukaryotes, the N-end rule pathway is a part of the UPS. The N-end rule relates the regulation of the in vivo half-life of a protein to the identity of its N-terminal residue. Degradation signals (degrons) that are targeted by the N-end rule pathway include a set called N-degrons. E3 Ub ligases of the N-end r

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23

Vu, Tran Minh Tri. "Studies of the N-end Rule Pathway in Bacteria and Mammals." Thesis, 2017. https://thesis.library.caltech.edu/9887/7/Vu-Thesis%20-%202016-07-03.pdf.

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<p>Many intracellular proteins are either conditionally or constitutively short-lived, with in vivo half-lives that can be as brief as a minute or so. The regulated and processive degradation of intracellular proteins is carried out largely by the ubiquitin (Ub)-proteasome system (UPS), in conjunction with molecular chaperones, autophagy, and lysosomal proteolysis. The N-end rule pathway, the first specific pathway of UPS to be discovered, relates the in vivo half-life of a protein to the identity of its N-terminal residue. Physiological functions of the N-end rule pathway are strikingly broad

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24

Malladi, Madhavi 1976. "Regulation of DIAP1 function by Dropsophila Omi and the N-end rule pathway." Thesis, 2007. http://hdl.handle.net/2152/3629.

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The molecular mechanisms of apoptosis are evolutionarily-conserved with caspases being the chief executioners of this process. Though key regulators of apoptosis, including caspases, inhibitor of apoptosis (IAP) proteins, and IAP antagonists exist in both mammals and flies, there are reportedly mechanistic differences in the way the apoptotic process is executed. One of the differences pertains to the importance of mitochondrial permeabilization for caspase activation. Herein, we demonstrate that dOmi, a Drosophila homologue of the serine protease Omi/HtrA2, is a developmentallyregulated m

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25

Wadas, Brandon Christopher. "Biochemical and Genetic Studies of the N-End Rule Pathway in Yeast and Mammals." Thesis, 2016. https://thesis.library.caltech.edu/9826/1/20160603_Thesis_Wadas.pdf.

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<p>Regulation of the in vivo half-lives of intracellular proteins is an important cellular process. Many intracellular proteins are short-lived, owing to their regulated and processive degradation by the Ubiquitin (Ub)-Proteasome System (UPS). In eukaryotes, the N-end rule pathway is one specific pathway within the UPS. The N-end rule pathway relates the identity of the N-terminal residue of a protein, or a protein fragment, to its in vivo half-life. Substrates of the N-end rule pathway are recognized by the presence of degradation signals, termed N-degrons. Recognition components of the N-end

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26

Ashton-Beaucage, Dariel. "Identification et étude de mécanismes régulant l’expression de MAPK." Thèse, 2014. http://hdl.handle.net/1866/13523.

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Les fichiers accompagnant le document sont en format Microsoft Excel 2010.<br>Les modèles classiques de signalisation cellulaire eucaryotes sont généralement organisés en voies linéaires et hiérarchiques, impliquant un ensemble de facteurs restreint. Ces facteurs forment un circuit isolé qui transmet une information externe vers sa destination, d’où une réponse cellulaire sera alors engendrée. Or, ces modèles sont justement le fruit d’approches expérimentales réductionnistes qui ne permettent pas d’intégrer aisément la contribution de facteurs multiples, ni de faire une évaluation quantitative

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27

De, Villiers David. "Die verband tussen werknemersdiefstal en etiese werksklimaat in 'n versorgingsoord (Afrikaans)." Diss., 2004. http://hdl.handle.net/2263/26931.

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The perpetration of theft by employees in a nursing home is the subject of this study. The investigation focuses mainly on the theft of clients’/residents’ possessions by those people who are supposed to care for them. Previous research indicated a relationship between ethical climate and the behavioural outputs of employees in an organization. This research, which is mainly qualitative in nature, endeavours to study the assumed relation between ethical climate and theft by employees in a specific location, namely at Vergenoeg vir Seniors, an old age home in Pretoria. With the aid of a standar

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