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Dissertations / Theses on the topic 'The Study of Phospholipids'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Dunjić, Branko S. "Gastric mucosal protection an experimental study on the role of endogenous and exogenous phospholipids /." Lund : Dept. of Surgery, Lund University, 1993. http://catalog.hathitrust.org/api/volumes/oclc/39798502.html.

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2

Rosenberger, Thad A. "Ether phospholipid metabolism in the adult awake rat : a model to study the role of ether phospholipids in brain /." The Ohio State University, 2000. http://rave.ohiolink.edu/etdc/view?acc_num=osu1488193272067084.

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3

Matthews, Kevin Roger Kenneth. "The synthesis of phospholipids for the study of ion binding." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.238156.

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4

Mozsolits, Henriette 1971. "Surface plasmon resonance spectroscopy for the study of peptide-membrane interactions." Monash University, Dept. of Biochemistry and Molecular Biology, 2001. http://arrow.monash.edu.au/hdl/1959.1/8123.

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5

Yusuf, Kehinde Quasim. "An exploratory study of the potential of resurfacing articular cartilage with synthetic phospholipids." Thesis, Queensland University of Technology, 2013. https://eprints.qut.edu.au/63317/1/Kehinde_Yusuf_Thesis.pdf.

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This thesis is aimed at further understanding the uppermost lipid-filled membranous layer (i.e. surface amorphous layer (SAL)) of articular cartilage and to develop a scientific framework for re-introducing lipids onto the surface of lipid-depleted articular cartilage (i.e. "resurfacing"). The outcome will potentially contribute to knowledge that will facilitate the repair of the articular surface of cartilage where degradation is limited to the loss of the lipids of the SAL only. The surface amorphous layer is of utmost importance to the effective load-spreading, lubrication, and semipermeabi

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6

Gale, Paul. "Bacteriorhodopsin/phospholipid interactions : a study by ³¹P- and ²H-NMR." Thesis, University of Oxford, 1988. http://ora.ox.ac.uk/objects/uuid:e5f11388-8613-442d-9a13-d20eea92bc84.

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Two methods were used to produce exogenous lipid/bR complexes. A detergent method (Huang et al., 1980) reconstituted bR into DMPC or DMPG bilayers, free of all endogenous purple membrane lipids as shown by high resolution <sup>31</sup> P-NMR. A novel biological detergent-free method employed bovine liver non-specific lipid transfer protein (nsTP) to mediate addition of DMPC to purple membrane, while retaining 76 - 86% of the endogenous purple membrane phospholipids. The variations with temperature of 2H-NMR quadrupole splittings for the DMPC choline α- and β-methylene CD2 segments were similar

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7

Leekumjorn, Sukit. "Molecular Dynamics Simulations for the Study of Biophysical Processes on Biological Membranes." Diss., Virginia Tech, 2008. http://hdl.handle.net/10919/29180.

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Phospholipid bilayers constitute the primary structural element of biological membranes, and as such, they play a central role in biochemical and biophysical processes at the cellular level, including cell protection, intercellular interactions, trans-membrane transport, cell morphology, and protein function, to name a few. The properties of phospholipid bilayers are thus of great interest from both experimental and theoretical standpoints. Although experiments have provided much of the macroscopic functions and properties of biological membranes, insight into specific mechanisms at the mole

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8

Tweed, Stephanie. "Prokaryotic lipidomics : development of a method to study the phospholipids in E. coli and B. subtilis." Thesis, University of Southampton, 2012. https://eprints.soton.ac.uk/354590/.

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The way in which prokaryotes, particularly Gram-negative bacteria, regulate their lipid compositions in response to changes in their growth media can provide insights into how bacteria adapt to life in oligotrophic environments. In this thesis, it is reported how electrospray ionisation mass spectrometry (ESI-MS) techniques can be adapted to map the impact of growth conditions on the regulation of the phospholipid biosynthetic pathways in E. coli and B. subtilis. Reliable counting of bacterial number densities is one of the main barriers to achieving reproducible quantitative lipid composition

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9

Ibrahim, Akram Yousif. "A study of DPPC and DMPC monolayers at different temperatures using epifluorescence surface balance." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ54924.pdf.

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10

Granata, A. "¿ALTERATIONS OF CHOLINE PHOSPHOLIPID METABOLISM IN OVARIAN CANCER: STUDY OF THE ACTIVITY AND EXPRESSION OF CHOLINE KINASE AS A PROGNOSTIC VALUE¿." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/243349.

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Epithelial ovarian cancer (EOC) is a highly lethal malignancy due to late diagnosis and early relapse associated with development of chemoresistance. So far, the origin of drug resistance is not completely understood and several mechanisms seem to be responsible for this process including the ability of cancer cells to modify/reprogram cellular metabolism. Aberrant choline metabolism, characterized by increased phosphocholine (PCho) levels sustained by enhanced choline kinase (ChoK) activity, is a new cancer metabolic hallmark that can be monitored by Magnetic Resonance Spectroscopy (MRS) and

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11

Ke, Lijing. "Mechanism of anti-influenza virus activity of Maillard reaction products derived from Isatidis roots." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/6501.

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The cyto-protective compositions and effects of antiviral Maillard reaction products (MRPs) derived from roots of Isatis indigotica F. were examined using biochemical and biophysical methods. The Maillard reaction was identified as the main source of compounds with antiviral activity, an observation which has led to the proposal of a new class of active compounds that protect cells from influenza virus infection. In the roots, arginine and glucose were revealed to be the predominant reactants for the Maillard reaction. Significant anti-influenza virus effects were demonstrated in the RIE MRPs

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12

Zhang, Wei. "Development of Photochemically Initiated Direct and Indirect Luminescence Detection Methods for Liquid Chromatography (LC) and Study of Aromatic Sulfonates and Phospholipids Using Reversed Phase Ion-Pair LC-Mass Spectrometry." Miami University / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=miami1068739487.

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13

Wohl, Christopher John Jr. "Photochemical Applications to the Study of Complexity Phospholipid Bilayer Environments." VCU Scholars Compass, 2006. http://scholarscompass.vcu.edu/etd/1269.

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The physical and biophysical properties of a biological membrane model, phosphatidylcholine bilayers, were investigated using novel spiropyran/merocyanine molecular probes. The femtosecond to second dynamics of this system's photochemistry enabled bilayer viscosity and free volume to be studied over a broad time scale. Spiropyrans/merocyanines with different polarity were synthesized by changing the substitution of the indole moiety enabling determination of the trans-membrane properties of the bilayer. In addition, transient grating spectroscopy was used to study thermal energy transfer in ph

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14

Barriocanal, Gil Leticia. "A calorimetric study of the formation and stability of phospholipid vesicles." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409578.

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15

Williams, Thomas Lloyd. "Tethered biomimetic phospholipid vesicles : a novel method to study membrane permeation." Thesis, University of Bath, 2007. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.485126.

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The cell membrane provides a barrier and maintains the equilibrium between the intracellular and extracellular spaces. It regulate the flux of ions, metabolites and cellular components, and also acts to regulate the communication between the cells. However, any change in the cell membrane, as a result of mechanical, biological or chemical damage, may significantly alter the structure and function of the cell. Various protein toxins, such as lipolytic enzymes and pore-forming bacterial toxins, have developed means to circumvent this barrier to gain access to resources. The interaction between t

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16

Popendorf, Kimberly J. (Kimberly Julia). "Marine microbial intact polar diacylglycerolipids and their application in the study of nutrient stress and bacterial production." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/79293.

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Thesis (Ph. D.)--Joint Program in Oceanography/Applied Ocean Science and Engineering (Massachusetts Institute of Technology, Dept. of Biology; and the Woods Hole Oceanographic Institution), February 2013.<br>"February 2013." Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Intact polar diacylglycerolipids (IP-DAGs) were used to study microbial dynamics in the surface ocean. IP-DAGs from surface ocean seawater were quantified using high performance liquid chromatography-mass spectrometry (HPLC-MS), after first developing a sensitive, high throughput molecular ion

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17

Bao, Yongping. "A study of the role of the selenoenzyme : phospholipid hydroperoxide glutathione peroxidase." Thesis, University of East Anglia, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317979.

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18

Saint, Ruth Helen Margaret. "A study on the formulation, characterisation and release properties of phospholipid microemulsions." Thesis, University of Manchester, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.588606.

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This thesis reports on the formulation, characterisation and in-vitro release characteristics of oil-in-water microemulsions containing egg or soya lecithin, ethanol, isopropyl myristate and water. The use of lecithin as a surfactant in the formulation of pharmaceutical microemulsions has been discussed. The various techniques used for particle size determination and the application of microemulsions in drug delivery have been reviewed. Oil-in-water microemulsion regions were detected for systems containing egg or soya lecithin/isopropyl myristate/ethanol/water with continuous phases of 80%, 7

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19

Martínez-Seara, Monné Hector. "Theoretical Study of Phospholipid Membranes: the Complex Role of Cholesterol and Lipid Unsaturation." Doctoral thesis, Universitat de Barcelona, 2010. http://hdl.handle.net/10803/35684.

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The Doctoral dissertation titled “Theoretical Study of Phospholipid Membranes: the Complex Role of Cholesterol and Lipid Unsaturation” covers biological membrane modeling by means of molecular dynamics. The main focus of the dissertation is to study the role of phospholipid unsaturation and cholesterol in animal cell membrane properties. In general, it aims to find the molecular mechanisms underlying naturally occurring phenomena, such as the preference displayed by nature for phospholipids with an unsaturated sn-2 chain where the double bond is placed in its middle. Significant results we

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20

Hurst, Rachel. "A study of the role of phospholipid hydroperoxide glutathione peroxidase activity in humans." Thesis, University of East Anglia, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301996.

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21

Berggren, Anders. "LCA of Egg Phospholipids." Thesis, KTH, Industriell ekologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-134201.

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Egg phospholipids are a group of fats or lipids in the egg yolk, commonly used as emulsifiers in the chemical industry to facilitate the dissolving of substances. The pharmaceutical company Fresenius-Kabi manufactures this product and seeks a better understanding of the product’s major environmental impacts in order to comply with the ISO 14001 requirements, communicate its environmental performance and choose raw materials that result in lower environmental impacts. The aim of this study is to quantify and identify environmental impacts that occur in the life cycle of Fresenius-Kabi’s egg pho

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22

Vacklin, Hanna P. "Phospholipase Aâ‚‚ action at solid supported phospholipid membranes : a neutron reflection and ellipsometry study." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398262.

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23

Stewart, Laura. "Physical studies of diphytanylglycerol phospholipids." Thesis, University of Ottawa (Canada), 1988. http://hdl.handle.net/10393/5405.

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24

Cuccia, Louis A. "Biophysical properties of dimeric phospholipids." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0023/NQ29914.pdf.

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25

Mohan, Vijitha. "SELECTIVE ESTER CLEAVAGE IN PHOSPHOLIPIDS." MSSTATE, 2008. http://sun.library.msstate.edu/ETD-db/theses/available/etd-07112008-141938/.

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Selective ester bond cleavage using lithium and zinc halides was attempted in a select group of phospholipids, namely phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylserine (PS). Several reaction parameters including catalyst (lithium chloride, lithium bromide, lithium iodide, zinc chloride, zinc bromide and zinc iodide), reaction temperature (21, 30, 50 and 60 <sup>o</sup>C), and reaction time (2 and 4 hours) were varied and the effects on cleavage studied. Reacted phospholipid samples were characterized by attenuated total reflectance (ATR) and transmission FTIR spec

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26

Cuccia, Louis A. "Biophysical properties of dimeric phospholipids." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=42007.

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A series of unusual bipolar and bis-phospholipids (dimeric phospholipids) have been studied. The structure, conformation, morphology and biophysical properties of the resulting phospholipid aggregates were investigated.<br>Deuterium magnetic resonance spectroscopy ($ sp2$H NMR) was used to study and characterize the conformation and acyl chain order in oriented bipolar lipid membranes. The $ sp2$H-NMR studies indicated a large and constant value for the order parameter (S$ rm sb{mol})$ for all positions along the bipolar lipid diacyl chain for mechanically oriented, magnetically oriented and u

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27

Tan, Lee Aun. "Immune system interactions with phospholipids." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404272.

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28

Mackenzie, Andrew Neil. "The synthesis of novel phospholipids." Thesis, University of Southampton, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261435.

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29

Lee, Youn-Sik. "Supramolecular assemblies of polymerizable phospholipids." Diss., The University of Arizona, 1992. http://hdl.handle.net/10150/185929.

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Novel polymerizable ether lipids, 1,2-O-bis[10-(2',4'-hexadienoyloxy)decyl]-rac, 1,2-O-bis(10,12-tricosadiynyl)-rac, and (S)-2,3-O-bis(10,12-tricosadiynyl)-sn-glycero-1-phosphocholine (PC), were successfully synthesized. Differential scanning calorimetry (DSC) showed that the gel to liquid crystalline phase transition of the ether lipid bilayers occurs at 11.4, 27.6, and 30.0°C (T(m)), respectively. The T(m) of the saturated analogs of the sorbyl ether and ester lipids, which were synthesized for the study of lipid phase behavior, were -15.4 and -7.5°C, respectively. The sorbyl and diacetyleni

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30

Pinheiro, Teresa J. T. "The interaction of cytochrome c with anionic phospholipid bilayers : a nuclear and electron magnetic resonance study." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333368.

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31

GIANNANGELI, MATTEO. "A DETAILED STUDY OF PROTEIN-SUPPORTED PHOSPHOLIPID BILAYER SYSTEMS AS MODEL INTERFACES TO INVESTIGATE BIOMEMBRANE INTERACTIONS." Doctoral thesis, Università degli Studi di Milano, 2022. http://hdl.handle.net/2434/930486.

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The cell membrane allows the maintenance of the intracellular content compatible with the work and life needs of the cell itself thanks to precise properties of permeability and capacity to transport ions and nutrients. Therefore, the integrity of this membrane, as well as that of proteins that carry out the function of transporting ions (such as ion channels), is a crucial topic in research and medicine. The main goals of my PhD project were: 1) The characterization, by means of AFM, of the morphological properties of the iron storing protein ferritin. 2) The study of the movement of the abov

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32

Mozuraityte, Revilija. "Oxidation of marine phospholipids in liposomes." Doctoral thesis, Norwegian University of Science and Technology, Department of Biotechnology, 2007. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-2008.

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<p>Marine phospholipids contain a high amount of n-3 polyunsaturated fatty acids (PUFAs), which have documented beneficial effect on human health. Due to this, marine phospholipids have a high potential for use in products for human consumption. However, due to the high amount of n-3 PUFAs, marine phospholipids are very susceptible to lipid oxidation, which cause loss of sensory and nutritional value in foods, some oxidation compounds are even toxic. A successful incorporation of marine phospholipids in processed foods would most probably be in the form of lipid dispersions, where some common

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33

Watts, Emma Elizabeth. "Phosphorus-31 NMR of sediment phospholipids." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0008/MQ42111.pdf.

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34

Arthur, John Simon Campbell. "Regulation of m-calpain by phospholipids." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240569.

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35

Rogerson, Madeleine. "Interactions of phospholipids with fatty acids." Thesis, University of East Anglia, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398493.

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36

Crosby, John. "Interactions between prostaglandins, phospholipids and spermatozoa." Thesis, University of Edinburgh, 1988. http://hdl.handle.net/1842/18806.

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37

Montano, Machado Vanessa. "Fibronectin/phosphorylcholine coatings on fluorocarboned surfaces : a study upon adsorption and grafting processes." Doctoral thesis, Université Laval, 2016. http://hdl.handle.net/20.500.11794/26798.

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Depuis ces dernières décennies, le domaine des biomatériaux a connu un essor considérable, évoluant de simples prothèses aux dispositifs les plus complexes pouvant détenir une bioactivité spécifique. Outre, le progrès en science des matériaux et une meilleure compréhension des systèmes biologiques a offert la possibilité de créer des matériaux synthétiques pouvant moduler et stimuler une réponse biologique déterminée, tout en améliorant considérablement la performance clinique des biomatériaux. En ce qui concerne les dispositifs cardiovasculaires, divers recouvrements ont été développés et étu

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38

Faxén, Kristina. "Active transport of ions across biomembranes : a kinetic study of cytochrome c oxidase reconstituted into phospholipid vesicles /." Stockholm : Department of Biochemistry and Biophysics, stockholm university, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-6806.

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39

Hague, Charlotte. "A quantitative characterisation of phospholipid composition and biosynthesis in HeLa cells and nuclei : a mass spectrometry study." Thesis, University of Southampton, 2010. https://eprints.soton.ac.uk/173965/.

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Nuclei from Human cells have been shown to contain a pool of endonuclear phospholipidthat is distinct from the nuclear membrane. It has been suggested that this endonuclear phospholipid is involved in the regulation of nuclear processes such as transcription. This study utilised tandem electrospray ionisation mass spectrometry to determine, quantitatively, the phospholipid content of cultured HeLa (Human cervical carcinoma) cells and their isolated naked nuclei. Endonuclear PC, DAG and PI was found to be enriched in disaturated molecular species with respect to the whole cell.Whole cell and en

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40

Zhou, Jin. "Study and development of a 'smart' wound dressing technology which can detect and inhibit/kill the colonisation of pathogenic bacteria." Thesis, University of Bath, 2011. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.545335.

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Bacterial infections are a serious problem for patients with burns and other wounds. Such burn wound infection accounts for the pathogenic bacteria by colonising onto burned areas. Therefore, the need for detection and inhibition of such bacterial colonisation requires a methodology for sensing/killing pathogenic bacteria. This research project aims to design a ‗smart‘ wound dressing system which can respond to the microbiological environment of the wound via a simple colour change and will release antimicrobials only when required. Two strains of pathogenic bacteria Staphylococcus aureus (MSS

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41

Mangavel, Cécile. "Peptides amphiphiles hélicogènes : comportement en solution aqueuse et interaction avec des membranes modèles." Orléans, 1996. http://www.theses.fr/1996ORLE2043.

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Les interactions entre peptides amphiphiles helicogenes et membranes jouent un role fondamental dans de nombreux mecanismes biologiques. D'une grande diversite de sequences primaires, ces peptides possedent la propriete commune d'adopter une structure secondaire d'helice alpha en presence de membranes. Il semble donc que ce soit cette structure secondaire qui gouverne reellement l'interaction membranaire. Au cours de ce travail, nous nous sommes interesses a des peptides modeles dont les sequences primaires alternent residus hydrophiles et hydrophobes afin de favoriser la formation d'helices a

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42

Rajagopal, Badri S. "Interactions of mitochondrial cytochrome c with phospholipids." Thesis, University of Essex, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.589541.

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Mitochondrial cytochrome c (cyt c) associates with the phospholipid cardiolipin (Cl) through a combination of electrostatic and hydrophobic interactions. The latter occurs by insertion of an acyl chain into cyt c, resulting in the dissociation of the axial Met-80 haem-iron ligand resulting in a five coordinate cyt c/Cl complex that exhibits peroxidatic properties leading to peroxidation of Cl and dissociation of the complex. These events are considered to be pre-apoptotic and culminate with release of cyt c from the mitochondria into the cytoplasm. Two distinct surface regions on cyt c have be

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43

Lexelius, Rebecka. "Formation of Monolayered Phospholipids using Molecular Dynamics." Thesis, Uppsala universitet, Molekyl- och kondenserade materiens fysik, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-356370.

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The very fundamental properties of biological membranes can be understood by studying their formation. This sets a good foundation for research related to how the membranes interact with organic molecules and ions; something of great value in the quest of explaining transport phenomena through cell membranes. It is furthermore of growing interest within the pharmacological research and contributes to the apprehension of life at the molecular level. In this thesis Molecular Dynamics has been used to simulate how evenly distributed phospholipids solvated in water leads to the formation of monola

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44

周, 哲. "NMR studies of phospholipids and liposomal membranes." Kyoto University, 1997. http://hdl.handle.net/2433/202364.

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45

Wat, Chi Ling Elaine. "Dietary milk phospholipids and their effects on cardiovascular risk factors / Chi Ling Elaine Wat." Thesis, The University of Sydney, 2009. https://hdl.handle.net/2123/28853.

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Cardiovascular disease is responsible for a significant portion of morbidity and mortality in Australia. The metabolic syndrome, which is the clustering of cardiometabolic risk factors, is well known to be associated with increased risk of CVD. There is thus great interest in treating and preventing this metabolic disease. Pharmaceutical approaches to the treatment of the metabolic syndrome to this date have been inadequate. Increasing evidence suggests that dietary PLs may be potentially cardioprotective. The aim of this thesis is therefore to investigate the possibility that PLs can be extr

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46

Smeets, Edgar Felix. "Scrambling of membrane phospholipids in platelets and erythrocytes." [Maastricht : Maastricht : Universiteit Maastrich] ; University Library, Maastricht University [Host], 1996. http://arno.unimaas.nl/show.cgi?fid=6693.

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47

Maunder, Karen. "Dietary modification of membrane phospholipids in breast disease." Thesis, University of Surrey, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.291611.

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48

Kemball-Cook, G. "Interaction of factor VIII clotting protein with phospholipids." Thesis, Open University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375092.

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It was shown that addition of procoagulant phospholipid (PL) vesicles to F.VIII concentrate protected F.VIII:C from anti-F.VIII:C antibody inactivation, and that of the naturally-occurring PLs only phosphatidylserine (PS)-containing PL had this ability. By using a PL-F.VIII mixture as immunoadsorbent for anti-F.VIII:Ag 125I-Fab' label, an immunoradiometric assay (IRMA) for F.VIII:Ag was set up which showed sensitivity to the binding of the antigen to PL vesicles: studies showed that only PS and phosphatidic acid (PA) vesicles could bind F.VIII:Ag, and ultracentrifugation of F.VIII-PL mixtures

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49

Alvis, Simon. "Interactions of phospholipids with the potassium channel KcsA." Thesis, University of Southampton, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.417416.

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50

Ma, Xin. "The interaction between amyloid beta peptide and phospholipids." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/29637.

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The aim of the thesis project was to examine what form(s) of Amyloid beta (Aβ) (25-‐35) peptide interact with phospholipids in vitro and the implications of this for the mechanism of Alzheimer’s Diseases (AD). The mechanism of AD is thought to involve protein folding and misfolding. An increasing amount of evidence has shown that protein misfolding plays an important role in the biological and pathological processes of AD. Although seen as the biomedical markers of those diseases, the roles of amyloid aggregates themselves are still not fully understood. Whether the aggregates, or the monomer

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