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Journal articles on the topic 'The Study of Phospholipids'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Liu, Chen, and Fusheng Chen. "Study on the Stability Mechanism of Peanut OBs Extracted with the Aqueous Enzymatic Method." Foods 12, no. 18 (2023): 3446. http://dx.doi.org/10.3390/foods12183446.

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In this study, the internal relationships among oil bodies (OBs), the protein–phospholipid interactions in aqueous phase, oil–water interface behavior, and the stability of reconstituted OBs were analyzed from the bulk phase, interface, and macro perspectives, and the stability mechanism of OBs was discussed. OB proteins and phospholipids were combined through hydrophobic and electrostatic interactions, resulting in the stretching of protein conformation. OB proteins and phospholipids act synergistically to increase interface pressure and the rate of increase in interface pressure with relativ

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2

Pan, F. G., J. Liu, J. X. Yang, et al. "Research progress on the genesis and removal methods of non-hydratable phospholipids from vegetable oils." Grasas y Aceites 75, no. 1 (2024): e543. http://dx.doi.org/10.3989/gya.0325231.

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Vegetable oil phospholipids can be divided into hydratable phospholipids (HP) and non-hydratable phospholipids (NHP). The general process of alkali refining or hydration degumming can remove most of the phospholipids, and the rest is mainly non-hydratable phospholipids. A non-hydratable phospholipid has obvious hydrophobicity, which cannot be completely removed even after 16 times of washing, so the non-hydratable phospholipid is the main research target of vegetable oil degumming. In order to better understand and study the non-hydratable phospholipids, the chemical composition and origin of

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3

Vial, Thomas, Wei-Lian Tan, Eric Deharo, Dorothée Missé, Guillaume Marti, and Julien Pompon. "Mosquito metabolomics reveal that dengue virus replication requires phospholipid reconfiguration via the remodeling cycle." Proceedings of the National Academy of Sciences 117, no. 44 (2020): 27627–36. http://dx.doi.org/10.1073/pnas.2015095117.

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Dengue virus (DENV) subdues cell membranes for its cellular cycle by reconfiguring phospholipids in humans and mosquitoes. Here, we determined how and why DENV reconfigures phospholipids in the mosquito vector. By inhibiting and activating the de novo phospholipid biosynthesis, we demonstrated the antiviral impact of de novo–produced phospholipids. In line with the virus hijacking lipids for its benefit, metabolomics analyses indicated that DENV actively inhibited the de novo phospholipid pathway and instead triggered phospholipid remodeling. We demonstrated the early induction of remodeling d

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Lyutikov, Anatoly Anatolyevich, Victoria Yuryevna Markina, and Elena Slavomirovna Konoplenko. "FLAX SEED LECITHIN – CHEMICAL COMPOSITION AND PROSPECTS FOR USE." Chemistry of plant raw material, no. 2 (June 16, 2025): 399–406. https://doi.org/10.14258/jcprm.20250215685.

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The results of a study of the fractional and fatty acid composition of flax lecithin, as a promising physiologically active food additive, in comparison with soy, rapeseed and sunflower lecithins are presented. An experimental batch of lecithiin was produced at the oil extraction enterprise Belagroterminal LLC (Belarus). The phospholipid and fatty acid composition of lecithin phospholipids was determined by high-performance liquid chromatography. It was shown that in flax phospholipid the proportion of phosphatidylcholine is 45.0%, which is close to the phospholipid from soybean – 47.1%, and l

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5

Singh, Khushdeep, Gitanjali, Gurmeet Kaur, et al. "Comparative study of phospholipid content in breast milk of mothers at preterm and term babies." International Journal of Clinical Biochemistry and Research 9, no. 2 (2022): 160–62. http://dx.doi.org/10.18231/j.ijcbr.2022.031.

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Phospholipids play important roles in cell membrane integrity, neural and brain development, and inflammatory responses. Phospholipids are also important for the growth of infants and the neurological development and the neurological disorders.The aim of the present study was to determine and compare phospholipid content in breast milk of mothers at preterm and term babies.The present study was a hospital- based comparative and analytical study. The study was conducted over a period of 1 year on 60 samples. The study group comprised a total 60 individuals in which breast milk of mothers of pre

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6

BRIGHTON, Timothy A., Yan-Ping DAI, Philip J. HOGG, and Colin N. CHESTERMAN. "Microheterogeneity of beta-2 glycoprotein I: implications for binding to anionic phospholipids." Biochemical Journal 340, no. 1 (1999): 59–67. http://dx.doi.org/10.1042/bj3400059.

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Considerable interest is currently focused on the interactions of beta-2 glycoprotein I (β2GPI) and anti-phospholipid antibodies with anionic phospholipids in an attempt to understand the association between these antibodies and clinical diseases such as thrombosis. The interactions of β2GPI and anionic phospholipids have only been characterized partially, and the physiological role of this glycoprotein remains uncertain. In this study we have explored in detail the physical and phospholipid-binding characteristics of a number of β2GPI preparations. We have found (i) that perchloric acid-purif

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7

Liu, Ting-Ting, Shao-Jie Pang, Shan-Shan Jia, et al. "Association of Plasma Phospholipids with Age-Related Cognitive Impairment: Results from a Cross-Sectional Study." Nutrients 13, no. 7 (2021): 2185. http://dx.doi.org/10.3390/nu13072185.

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Decreased concentration of phospholipids were observed in brain tissue from individuals with dementia compared with controls, indicating phospholipids might be a key variable in development of age-related cognitive impairment. The reflection of these phospholipid changes in blood might provide both reference for diagnosis/monitoring and potential targets for intervention through peripheral circulation. Using a full-scale targeted phospholipidomic approach, 229 molecular species of plasma phospholipid were identified and quantified among 626 senile residents; the association of plasma phospholi

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8

Mansur, Herman S., and Juliano E. Oliveira. "QCM and FT-IR Study of Phospholipid Bilayers Obtained by Langmuir-Blodgett Method." Solid State Phenomena 121-123 (March 2007): 863–66. http://dx.doi.org/10.4028/www.scientific.net/ssp.121-123.863.

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The aim of this study was to characterize phospholipids bilayers deposited through Langmuir-Blodgett (LB) using Fourier Transform Infrared Spectroscopy (FTIR) and Quartz Crystal Microbalance (QCM) sensor. Phospholipids dimyristoylphosphatidylcholine (DMPC), dimyristoylphosphatidylethanolamine (DMPE), dipalmitoylphosphatidylethanolamine (DPPE) bilayers were deposited. Also, hybrid monolayer of DMPC/Cholesterol (DMPC/CHOL) was prepared. Phospholipid with concentration of 1 mg.ml-1 in chloroform solution was spread at the air-water interface of a Teflon-made LB trough containing a subphase of Mil

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9

Sayed, Ramadan Hashem, Kamal-Eldin A. Abou-Elhamd, Mohamed Abdel-Kader, and Tahia Hashem Saleem. "Study of surfactant level in cases of primary atrophic rhinitis." Journal of Laryngology & Otology 114, no. 4 (2000): 254–59. http://dx.doi.org/10.1258/0022215001905508.

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The surfactant system of the nose was examined biochemically in control cases and compared to cases of primary atrophic rhinitis. The study group included 25 cases with primary atrophic rhinitis compared to 10 normal volunteers. Biochemical analysis of the nasal aspirate in these cases revealed the presence of phospholipids constituting surfactant with phosphatidylcholine constituting 75.35 per cent of the total phospholipids. Biochemical analysis of the nasal aspirate in cases with primary atrophic rhinitis revealed a significant decrease in the total phospholipids compared to normal cases an

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10

Rudzite, Vera, Edite Jurika, Matthias Jäger, and Dietmar Fuchs. "Impairment of Lipid Metabolism Due to Deficiency of Pyridoxal-5-phosphate and/or Activated Immune system: its Interpretation." Pteridines 11, no. 4 (2000): 107–20. http://dx.doi.org/10.1515/pteridines.2000.11.4.107.

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Abstract Impairment of lipid metabolism due to excess metabolite accumulation induced by pyridoxal-5-phosphate (P-5-P)-deficiency and/or stimulated immune system has been studied and interpreted. Decreased amounts of phospholipids as well as deviations in phospholipid classes and fatty acid composition of phospholipids have been demonstrated due to kynurenine accumulation in the blood of P-5-P-deficient cardiovascular patients and white rats as well as in cardiovascular patients with activated immune system identified by an increased neopterin concentration in the blood (dilated cardiomyopathy

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11

Kontarov, N. A., I. V. Pogarskaya, N. V. Balaev, and N. V. Yuminova. "Study of surface-active properties antivirials compound 1-boraadamantane for model monomoleculars phosphlipids layers." Biomeditsinskaya Khimiya 59, no. 5 (2013): 519–22. http://dx.doi.org/10.18097/pbmc20135905519.

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The surface-active properties of 1-boraadamantane have been studied using model phospholipid monolayers. Results suggest that the increase in 1-boraadamantane concentrations from 10-7 to 10-6 M is accompanied by the increase of the area per phospholipid molecule. This decreases to frequency of lateral diffusion of phospholipids molecules, the potential difference and the angle of the phospholipid monolayer arrangement. These phenomena may lead to impossibility of interaction between the virus and cell membranes.

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12

Nuralieva, Dilafruz, Govhka Tulaboeva, Botir Kamolov, Farida Azizova, and Iqol Adilova. "EFFICACY OF TELMISARTAN GROUP IN PATIENTS ISCHEMIC HEART DISEASE WITH ARTERIAL HYPERTENSION." UZBEK MEDICAL JOURNAL 2, no. 2 (2021): 25–32. http://dx.doi.org/10.26739/2181-0664-2021-2-4.

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In the studyphospholipids, cholesterol and its metabolites play a special role in of biological membranes. Disruption of the phospholipid content of biological membranes is one of the main factors of pathological processes, because phospholipids make up the largest part of the lipids of biological membranes, as well as platelet membranes. The study examined the effect of telmisartan on the clinical hemodynamics and platelet membrane phospholipids, cholesterol metabolism in patients with ischemic heart diseaseandarterial hypertension during 8 weeks of therapy.Keywords:ischemic heart disease,art

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13

Beavis, Janine, John L. Harwood, Gerald A. Coles, and John D. Williams. "Synthesis of Phospholipids by Human Peritoneal Mesothelial Cells." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 14, no. 4 (1994): 348–55. http://dx.doi.org/10.1177/089686089401400407.

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Objective To assess the capacity of cultured human peritoneal mesothelial cells to synthesize choline-containing phospholipids. The study compares the phospholipids secreted from cultured cells with those which we, and others, have identified in the dialysate of patients treated by continuous ambulatory peritoneal dialysis (CAPD). Patients CAPD effluent was collected from 8 patients who had been receiving CAPD treatment for at least 11 months and who had normal ultrafiltration. Cell Cultures Using human omental tissue, homogeneous cultures of mesothelial cells were established. Methods Synthes

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14

Quan, Hongxuan, Yongjoon Kim, Lele Wu, Hee-Chul Park, and Hyeong-Cheol Yang. "Modulation of Macrophage Polarization by Phospholipids on the Surface of Titanium." Molecules 25, no. 11 (2020): 2700. http://dx.doi.org/10.3390/molecules25112700.

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Macrophage polarization has become increasingly important for the improvement of the biocompatibility of biomaterials. In this study, we coated Ti discs with phospholipids (phosphatidylserine/phosphatidylcholine [4:1 mole/mole]) by evaporating the solvent under vacuum, and observed the polarization of RAW 264.7 cells cultured on the discs. The coated discs were hydrated before cell culture was added. The shape of the hydrated phospholipids varied with the concentration of loaded phospholipids: a perforated layer (0.1 mM), tubules and spheres (1 mM), and spheres (10 mM). RAW 264.7 cells exhibit

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15

Phuong, Doan Lan, Thi Thuy Nguyen, Minh Quan Pham, et al. "Study on lipid and phospholipid composition from the seed oil of Dalbergia tonkinensis." Vietnam Journal of Science and Technology 61, no. 1 (2023): 57–63. http://dx.doi.org/10.15625/2525-2518/16559.

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The content and composition of classes and molecular species of phospholipid extracted from Dalbergia tonkinensis Prain (Cây Sưa) seed oil in Viet Nam have been investigated using HPLC-HRMS and LCMS-IT-TOF. The content of phospholipid subclasses and their molecular species of D. tonkinensis seed oil have been investigated for the first time. The results showed that D. tonkinensis seed oil contains all basic classes of lipid: polar lipid, sterol, triacylglycerol, free fatty acid, diacylglycerol, hydrocarbon, and wax. In which, the content of triacylglycerol accounts for the highest percentage o

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16

Ovsepyan, L. M., A. V. Zanginyan, and G. S. Kazaryan. "Investigation of erythrocyte membrane lipid profile and phospholipids peroxidation process in liver echinococcosis." Epidemiology and Infectious Diseases 17, no. 4 (2012): 21–23. http://dx.doi.org/10.17816/eid40642.

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A study on the phospholipid content and the process of peroxidation of phospholipids in erythrocyte membranes of patients with liver ehinokkom patients before surgery and after surgery for 3—10 days. Found to change in the qualitative and quantitative content of phospholipids and activation of free radical processes in patients with hepatic echinococcosis before operation. After surgery, the 10 day trend towards normalization of the studied processes.

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17

Zhou, Qing, Hui Li, Yi-Peng Qi, and Feng Yang. "Lipid of white-spot syndrome virus originating from host-cell nuclei." Journal of General Virology 89, no. 11 (2008): 2909–14. http://dx.doi.org/10.1099/vir.0.2008/002402-0.

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The hypothesis that white-spot syndrome virus (WSSV) generates its envelope in the nucleoplasm is based on electron microscopy observations; however, as yet there is no direct evidence for this. In the present study, the lipids of WSSV and the nuclei of its host, the crayfish Procambarus clarkii, were extracted and the neutral lipid and phospholipid contents were analysed by high-performance liquid chromatography, thin-layer chromatography and gas chromatography/mass spectrometry. Phosphatidylcholine (PC) and phosphatidylethanolamine comprised 62.9 and 25.8 %, respectively, of WSSV phospholipi

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18

Pan, Yue, Lei Zhang, Xuanfei Fu, et al. "Addition of Phospholipids Improved the Physical Stability and Fat Globule Structure of Processed Milk." Foods 14, no. 3 (2025): 375. https://doi.org/10.3390/foods14030375.

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The manufacturing processes for infant formula disrupt the structure of phospholipid-coated milk fat globules, thereby impacting the physical stability of the system. In this study, either soybean phospholipids (SPs) or egg yolk phospholipids (EYPs) were incorporated into the milk system to reduce this damage, and their effects on the stability and fat globule structure of processed milk were examined. The findings revealed that the addition of phospholipids improved the physical stability and fat globule structure of different processed milk. In pasteurized milk, the stability constant of sam

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19

Sulaiman, Khaulah, Wan Haliza Abd Majid, and Muhamad Rasat Muhamad. "Molecular Orientation of Phospholipid Langmuir-Blodgett Films." Materials Science Forum 517 (June 2006): 65–68. http://dx.doi.org/10.4028/www.scientific.net/msf.517.65.

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The molecular organization of the phospholipids Langmuir-Blodgett (LB) films on solid substrates has been studied via Fourier Transform Infra Red (FTIR) spectroscopy. In this study, the formation of well organized ultra thin LB films of phospholipid molecules has been performed by depositing the monolayer onto the solid substrates of silicon wafer. The space filling molecular models of two types of phospholipids have been proposed on the basis of the FTIR spectra.

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20

Razi, F., M. Yulia, N. M. Erfiza, and A. Asnawi. "Study on the separation of phospholipids from crude palm oil using a polyethersulfone ultrafiltration membrane." IOP Conference Series: Earth and Environmental Science 922, no. 1 (2021): 012068. http://dx.doi.org/10.1088/1755-1315/922/1/012068.

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Abstract Crude Palm Oil (CPO) extracted from the palm fresh fruit bunches (FFB) should be refined to meet the specified quality for edible oils. One of the components that are removed in the CPO refining process is a phospholipid. Phospholipids are undesirable because they form mucus (gum) in CPO and enhance the emulsion formation during oil processing. As one of the emerging separation processes, membrane technology could be proposed on phospholipid removal in CPO. The research objectives are to synthesize polyethersulfone (PES) ultrafiltration (UF) membrane and evaluate its performance on ph

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Zlomke, Christin, Johannes Albrecht, and Karsten Mäder. "Nicardipine Loaded Solid Phospholipid Extrudates for the Prevention of Cerebral Vasospasms: In Vitro Characterization." Pharmaceutics 12, no. 9 (2020): 817. http://dx.doi.org/10.3390/pharmaceutics12090817.

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The aim of the study was to develop nicardipine loaded phospholipid extrudates as an alternative for PLA/PLGA-based implants for the prevention of cerebral vasospasms. Extrudates of different mixtures of saturated and unsaturated phosphatidylcholine (PC) were produced and characterized by DSC, microscopy and texture analysis. Single phospholipid components were identified by ELSD-HPLC. Extrudates of 2 mm diameter were obtained by twin screw extrusion temperatures below 50 °C. The ratio of unsaturated and saturated phosphatidylcholine components determines the physicochemical properties of the

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Chen, Alice, and Sheila Innis. "Assessment of Phospholipid Malabsorption by Quantification of Fecal Phospholipid." Journal of Pediatric Gastroenterology and Nutrition 39, no. 1 (2004): 85–91. http://dx.doi.org/10.1002/j.1536-4801.2004.tb12297.x.

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ABSTRACTObjectives:The standard methods for quantifying fat absorption involve extraction of fat from fecal samples with heptane, ether and ethanol. These solvents do not quantitatively recover phospholipids. Malabsorption of dietary and biliary phosphatidylcholine could potentially result in choline deficiency. Therefore, the authors developed a method extracting and quantifying fecal phospholipids.Methods:Fecal samples were collected for 72 hours from 18 children with cystic fibrosis and 10 control children. Fat was extracted first with hexane/diethyl ether/ethanol and then with chloroform/m

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23

Bačinić, Anđela, Petra Vukosav, Ivana Kero, and Marina Mlakar. "Study on the Surface Interactions of Co(II) with Phospholipids from the Marine Environment." Journal of Marine Science and Engineering 10, no. 9 (2022): 1261. http://dx.doi.org/10.3390/jmse10091261.

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Natural phospholipid (PL)n extract from cultured green algae Dunaliela tertiolecta was used as the main component of cell membranes for studies on the interaction with trace metal Co(II). The phospholipids of the membranes were extracted from other biological components using TiO2-µSPE cartridges selective for the phosphate group according to a completely new protocol. The interaction of Co(II) with natural and standard phospholipids, phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylglycerol (PG) are registered only in the presence of the additional chelating ligand 1,1

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Diez, E., F. H. Chilton, G. Stroup, R. J. Mayer, J. D. Winkler, and A. N. Fonteh. "Fatty acid and phospholipid selectivity of different phospholipase A2 enzymes studied by using a mammalian membrane as substrate." Biochemical Journal 301, no. 3 (1994): 721–26. http://dx.doi.org/10.1042/bj3010721.

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Previous studies using phospholipid mixed vesicles have demonstrated that several types of phospholipase A2 (PLA2) enzymes exhibit different selectivity for fatty acids at the sn-2 position, for the type of chemical bond at the sn-1 position or for the phosphobase moiety at the sn-3 position of phospholipids. In the present study, we have utilized natural mammalian membranes from U937 monocytes to determine whether two purified 14 kDa PLA2 isoenzymes (Type I, Type II) and a partially purified 110 kDa PLA2 exhibit substrate selectivity for certain fatty acids or phospholipids. In these studies,

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Ahn, Yejin, Min Guk Kim, Kyungae Jo, Ki-Bae Hong, and Hyung Joo Suh. "Effects of Sphingomyelin-Containing Milk Phospholipids on Skin Hydration in UVB-Exposed Hairless Mice." Molecules 27, no. 8 (2022): 2545. http://dx.doi.org/10.3390/molecules27082545.

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Reactive oxygen species (ROS) generated by ultraviolet (UV) exposure cause skin barrier dysfunction, which leads to dry skin. In this study, the skin moisturizing effect of sphingomyelin-containing milk phospholipids in UV-induced hairless mice was evaluated. Hairless mice were irradiated with UVB for eight weeks, and milk phospholipids (50, 100, and 150 mg/kg) were administered daily. Milk phospholipids suppressed UV-induced increase in erythema and skin thickness, decreased transepidermal water loss, and increased skin moisture. Milk phospholipids increased the expression of filaggrin, invol

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Mwiiri, Francis Kamau, and Rolf Daniels. "Optimized Birch Bark Extract-Loaded Colloidal Dispersion Using Hydrogenated Phospholipids as Stabilizer." Pharmaceutics 12, no. 9 (2020): 832. http://dx.doi.org/10.3390/pharmaceutics12090832.

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This study investigated the formulation and processing of aqueous colloidal dispersions containing a birch bark dry extract (TE) as the active substance and hydrogenated phospholipids (Phospholipon 90H) as stabilizer, which can be used in the preparation of electrospun wound dressings. Colloidal dispersions manufactured using a two-stage homogenization process had a bimodal particle size distribution, which was most significantly (p < 0.0001) affected by the phospholipid content. The size of the single particles decreased from an average particle size of about 4 µm to a particle size of app

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Carman, George M., and Michael C. Kersting. "Phospholipid synthesis in yeast: regulation by phosphorylation." Biochemistry and Cell Biology 82, no. 1 (2004): 62–70. http://dx.doi.org/10.1139/o03-064.

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The yeast Saccharomyces cerevisiae is a model eukaryotic organism for the study of the regulation of phospholipid synthesis. The major phospholipids (phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, and phosphatidylserine) are synthesized by complementary (CDPdiacylglycerol and Kennedy) pathways. The regulation of these pathways is complex and is controlled by genetic and biochemical mechanisms. Inositol plays a major role in the regulation of phospholipid synthesis. Inositol-mediated regulation involves the expression of genes and the modulation of enzyme activities. Phos

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Xi, Quan, Zhen Cao, Jia-Ying Miao, and Hao Wang. "The Study of Spray-Freeze-Drying Technique for Development of Novel Combination pMDIs, Part II: In Vitro and In Vivo Evaluations." Pharmaceutical Fronts 04, no. 04 (2022): e275-e283. http://dx.doi.org/10.1055/s-0042-1758388.

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AbstractThe mometasone furoate (MF) and formoterol fumarate dihydrate (FF) inhalable microparticles prepared by different methods, such as micronized active pharmaceutical ingredients (APIs), microparticles of APIs prepared by spray-freeze drying technique (SFD APIs), and phospholipid microparticles of APIs prepared by SFD (SFD Lip-APIs), showed different inhaled drug delivery characteristics. Study on the physicochemical characteristics of those microparticles and the effect of matrix excipients on pharmacokinetic (PK) behaviors of inhalable microparticles is helpful for the development of ne

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Ravić, Branko, Jasmina Debeljak-Martacić, Biljana Pokimica, et al. "The Effect of Fish Oil-Based Foods on Lipid and Oxidative Status Parameters in Police Dogs." Biomolecules 12, no. 8 (2022): 1092. http://dx.doi.org/10.3390/biom12081092.

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The synthesis, degradation, and reconstruction of the cell membrane as a metabolic pathway of phospholipids is a constant and dynamic process. Fatty acids as bioactive lipid components of plasma and erythrocyte phospholipids as structural lipids have biological roles in the integrity of cell membranes. Fatty acids, depending on the chain length, the degree of saturation, and the synthesis pathways, can alleviate inflammation and oxidative stress caused by excessive exercise. Considering that changing food intake or diet can influence fatty acid phospholipid metabolism, our study aimed to deter

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Thøgersen, Rebekka, Ida Emilie I. Lindahl, Bekzod Khakimov, et al. "Progression of Postprandial Blood Plasma Phospholipids Following Acute Intake of Different Dairy Matrices: A Randomized Crossover Trial." Metabolites 11, no. 7 (2021): 454. http://dx.doi.org/10.3390/metabo11070454.

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Studies have indicated that the dairy matrix can affect postprandial responses of dairy products, but little is known about the effect on postprandial plasma phospholipid levels. This study investigated postprandial plasma phospholipid levels following consumption of four different dairy products that are similar in micro and macro nutrients, but different in texture and structure: cheddar cheese (Cheese), homogenized cheddar cheese (Hom. Cheese), micellar casein isolate with cream (MCI Drink) or a gel made from the MCI Drink (MCI Gel). The study was an acute randomized, crossover trial in hum

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Das, D. K., R. M. Engelman, J. A. Rousou, R. H. Breyer, H. Otani, and S. Lemeshow. "Role of membrane phospholipids in myocardial injury induced by ischemia and reperfusion." American Journal of Physiology-Heart and Circulatory Physiology 251, no. 1 (1986): H71—H79. http://dx.doi.org/10.1152/ajpheart.1986.251.1.h71.

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Depletion of membrane phospholipids is known to be associated with myocardial ischemia, but its relationship to the injury involved with the reperfusion of ischemic myocardium is not known. The present study was designed to relate phospholipid degradation with reperfusion injury. The isolated in situ pig heart was subjected to 60 min of regional ischemia induced by occluding the left anterior descending (LAD) coronary artery and 60 min of global ischemia by hypothermic cardioplegic arrest followed by 60 min of reperfusion. The pigs were divided into two groups. In the treatment group, the hear

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Bunyatyan, N. D., B. B. Sysuev, and L. L. Nikolaeva. "Interchangeability of Essential Phospholipid Products." Bulletin of the Scientific Centre for Expert Evaluation of Medicinal Products 9, no. 4 (2019): 241–47. http://dx.doi.org/10.30895/1991-2919-2019-9-4-241-247.

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A significant share of the hepatoprotectors pharmaceutical market is represented by innovator and generic products containing essential phospholipids. One of the main issues in pharmacotherapy is confirmation of similarity between reference and generic products, which helps to assess their interchangeability. Therefore, it seems relevant to conduct comparative studies examining the products’ formulations (content of active pharmaceutical ingredients and excipients), dosage forms and routes of administration to identify characteristics that can affect interchangeability of essential phospholipi

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Liu, X. K., M. R. Prasad, R. M. Engelman, R. M. Jones, and D. K. Das. "Role of iron on membrane phospholipid breakdown in ischemic-reperfused rat heart." American Journal of Physiology-Heart and Circulatory Physiology 259, no. 4 (1990): H1101—H1107. http://dx.doi.org/10.1152/ajpheart.1990.259.4.h1101.

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Oxygen-derived free radicals have been implicated in causing degradation of myocardial membrane phospholipids associated with ischemia and reperfusion. Since iron is known to catalyze the hydroxyl radical formation responsible for cellular injury, this study was designed to relate the role of iron with phospholipid breakdown in ischemic-reperfused heart. Isolated rat heart perfused by the Langendorff technique was subjected to 30 min of normothermic ischemia followed by 30 min of reperfusion. The experimental group received 0.6 mM deferoxamine, an iron chelator, before reperfusion of ischemic

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Ciura, Krzesimir, Joanna Fedorowicz, Hanna Kapica, Alicja Adamkowska, Wiesław Sawicki, and Jarosław Sączewski. "Affinity of Fluoroquinolone–Safirinium Dye Hybrids to Phospholipids Estimated by IAM-HPLC." Processes 8, no. 9 (2020): 1148. http://dx.doi.org/10.3390/pr8091148.

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Nowadays, fluoroquinolones (FQs) constitute one of the most important classes of antibiotics. FQs are used to treat infections caused by Gram-positive and Gram-negative species. A set of fluoroquinolone–Safirinium dye hybrids has been synthesized in our laboratory as potential new dual-action antibacterial agents. In the present study we have evaluated how such a modification influences the affinity of FQs to phospholipids. The immobilized artificial membrane (IAM) high-performance liquid chromatography (IAM-HPLC) was used as a tool for the determination of phospholipids partitioning. The obta

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Jang, Hyun Jun, Kyoung Ja Kwon, Chan Young Shin, et al. "Investigation of Phospholipid Differences in Valproic Acid-Induced Autistic Mouse Model Brain Using Mass Spectrometry Imaging." Metabolites 13, no. 2 (2023): 178. http://dx.doi.org/10.3390/metabo13020178.

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Autism is a neurodevelopmental disorder for which the cause and treatment have yet not been determined. The polyunsaturated fatty acid (PUFA) levels change rapidly in the blood or cerebrospinal fluid of autistic children and PUFAs are closely related to autism spectrum disorder (ASD). This finding suggests that changes in lipid metabolism are associated with ASD and result in an altered distribution of phospholipids in cell membranes. To further understand ASD, it is necessary to analyze phospholipids in organs consisting of nerve cells, such as the brain. In this study, we investigated the ph

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Phillips, Gabrielle R., Sarah E. Hancock, Andrew M. Jenner, Catriona McLean, Kelly A. Newell, and Todd W. Mitchell. "Phospholipid Profiles Are Selectively Altered in the Putamen and White Frontal Cortex of Huntington’s Disease." Nutrients 14, no. 10 (2022): 2086. http://dx.doi.org/10.3390/nu14102086.

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Huntington’s disease (HD) is a genetic, neurodegenerative illness that onsets in late adulthood as a series of progressive and terminal cognitive, motor, and psychiatric deficits. The disease is caused by a polyQ mutation in the Huntingtin gene (HTT), producing a polyglutamine expansion in the Huntingtin protein (HTT). HTT interacts with phospholipids in vitro; however, its interactions are changed when the protein is mutated in HD. Emerging evidence suggests that the susceptibility of brain regions to pathological stimuli is influenced by lipid composition. This study aimed to identify where

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Aznar, Justo, Teresa Santos, and Juana Vallés. "“Ex Vivo” Influence of Fatty Acids from Plasma Cholesterol and Triglycerides on the Fatty Acid Pattern of Platelets." Thrombosis and Haemostasis 54, no. 03 (1985): 669–74. http://dx.doi.org/10.1055/s-0038-1660094.

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SummaryWe have studied “ex vivo”, in 92 normal subjects, the influence of fatty acids (FA) that esterify plasma cholesterol and triglycerides on the fatty acid composition of phospholipids, triglycerides and free fatty acid fractions in platelets.High and significant correlations (p <0.001) were found for some of the platelet phospholipid FA and the same FA that esterify plasma cholesterol [18:11 (r = 0.56); 18:2 (r = 0.71) and 20:5 (r = 0.42)] and plasma triglycerides [18:1* (r = 0.57) and 18:2 (r = 0.66)]. Some significant correlations were also found between some of the platelet triglyce

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Sulc, Alexandra, Péter Czétány, Gábor Máté, et al. "MALDI Imaging Mass Spectrometry Reveals Lipid Alterations in Physiological and Sertoli Cell-Only Syndrome Human Testicular Tissue Sections." International Journal of Molecular Sciences 25, no. 15 (2024): 8358. http://dx.doi.org/10.3390/ijms25158358.

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Azoospermia, the absence of sperm cells in semen, affects around 15% of infertile males. Sertoli cell-only syndrome (SCOS) is the most common pathological lesion in the background of non-obstructive azoospermia and is characterised by the complete absence of germinal epithelium, with Sertoli cells exclusively present in the seminiferous tubules. Studies have shown a correlation between successful spermatogenesis and male fertility with lipid composition of spermatozoa, semen, seminal plasma or testis. The aim of this research was to discover the correlation between the Johnsen scoring system a

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Bhange, Manjusha, and Amrapali Jadhav. "Formulation and Development of Novel Matrix Dispersion System based on Phospholipid Complex for Improving Oral Bioavailability of Ferulic Acid." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 12, no. 04 (2022): 1489–95. http://dx.doi.org/10.25258/ijddt.12.4.01.

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The usage of phospholipid complexes is one of the greatest ways to increase the oral poorly absorbed plant parts’ bioavailability components. However, the stickiness of due to the phospholipids, the inefficient breakdown of medications. To make the ferulic acid phospholipid complex (FAPLC) more dispersible and to create a dispersion of a matrix of ferulic acid according to the phospholipid complex (MD-FAPLC) utilizing a solvent evaporation method, pentaerythritol was used in this study. Pentaerythritol, phospholipid, and ferulic acid were mixed in a 1:2:5 ratio. Penta erythritol is used to enh

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Markart, Philipp, Clemens Ruppert, Friedrich Grimminger, Werner Seeger, and Andreas Günther. "Fibrinolysis-inhibitory capacity of clot-embedded surfactant is enhanced by SP-B and SP-C." American Journal of Physiology-Lung Cellular and Molecular Physiology 284, no. 1 (2003): L69—L76. http://dx.doi.org/10.1152/ajplung.00037.2002.

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Incorporation of pulmonary surfactant into fibrin inhibits its plasmic degradation. In the present study we investigated the influence of surfactant proteins (SP)-A, SP-B, and SP-C on the fibrinolysis-inhibitory capacity of surfactant phospholipids. Plasmin-induced fibrinolysis was quantified by means of a 125I-fibrin plate assay, and surfactant incorporation into polymerizing fibrin was analyzed by measuring the incorporation of3H-labeled L-α-dipalmitoylphosphatidylcholine into the insoluble clot material. Incorporation of a calf lung surfactant extract (Alveofact) and an organic extract of n

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Durrani, Rabia, Faez Iqbal Khan, Shahid Ali, Yonghua Wang, and Bo Yang. "A Thermolabile Phospholipase B from Talaromyces marneffei GD-0079: Biochemical Characterization and Structure Dynamics Study." Biomolecules 10, no. 2 (2020): 231. http://dx.doi.org/10.3390/biom10020231.

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Phospholipase B (EC 3.1.1.5) are a distinctive group of enzymes that catalyzes the hydrolysis of fatty acids esterified at the sn-1 and sn-2 positions forming free fatty acids and lysophospholipids. The structural information and catalytic mechanism of phospholipase B are still not clear. Herein, we reported a putative phospholipase B (TmPLB1) from Talaromyces marneffei GD-0079 synthesized by genome mining library. The gene (TmPlb1) was expressed and the TmPLB1 was purified using E. coli shuffle T7 expression system. The putative TmPLB1 was purified by affinity chromatography with a yield of 1

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Keys, J. E., A. E. Fekry, D. L. Wood, and A. V. Capuco. "The ability of bovine mammary tissue to synthesize lipids for 96 h when cocultured with liver and adipose tissue." Biochemistry and Cell Biology 70, no. 5 (1992): 343–46. http://dx.doi.org/10.1139/o92-053.

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Explants of bovine mammary, liver, and adipose tissues were cocultured in the same well for 24, 48, 72 or 96 h and their ability to synthesize lipids was measured by the incorporation of [14C]acetate into triglycerides, free fatty acids, and phospholipids. The model was developed to study the effect of bovine somatotropin on lipid synthesis in mammary tissue, because somatotropin will not affect mammary tissue unless liver tissue is present. Somatotropin reduced incorporation by mammary tissue relative to the control. However, the rate of incorporation remained constant through 96 h with somat

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Nguyen, Thi Phuong Lan, Van Tuyen Anh Nguyen, Thi Thanh Trung Do, Trung Nguyen Quang, Quoc Long Pham, and Tat Thanh Le. "Fatty Acid Composition, Phospholipid Molecules, and Bioactivities of Lipids of the Mud Crab Scylla paramamosain." Journal of Chemistry 2020 (March 19, 2020): 1–9. http://dx.doi.org/10.1155/2020/8651453.

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The mud crab increases the yield of farming in Southeast Asian countries. Scylla paramamosain, one of four mud crab species belonging to the Scylla genus, is a rich nutrient source during its soft-shell moulting period. In this study, we analysed the total lipid content, fatty acid components, and phospholipid molecular species of the S. paramamosain mud crab. The total lipid content was 1.62 ± 0.08%, which is similar to that of S. serrata previously reported. Twenty-one fatty acids were identified in S. paramamosain. The composition and molecular forms of the phospholipids were identified usi

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Huang, Jiahao, Peter Chen, Michael Rogers, and Shawn Wettig. "Investigating the Phospholipid Effect on the Bioaccessibility of Rosmarinic Acid-Phospholipid Complex through a Dynamic Gastrointestinal in Vitro Model." Pharmaceutics 11, no. 4 (2019): 156. http://dx.doi.org/10.3390/pharmaceutics11040156.

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Phyto-phospholipid complexes have been developed as a common way of improving the oral bioavailability of poorly absorbable phyto-pharmaceuticals; however, the complexation with phospholipids can induce positive or negative effects on the bioaccessibility of such plant-derived active ingredients in different parts of the gastrointestinal tract (GIT). The purpose of this study was to investigate the effects of phospholipid complexation on the bioaccessibility of a rosmarinic acid-phospholipid complex (RA-PLC) using the TNO dynamic intestinal model-1 (TIM-1). Preparation of RA-PLC was confirmed

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Liang, Hong, William R. Lykins, Emilie Seydoux, et al. "Formulated Phospholipids as Non-Canonical TLR4 Agonists." Pharmaceutics 14, no. 12 (2022): 2557. http://dx.doi.org/10.3390/pharmaceutics14122557.

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Immunogenic agents known as adjuvants play a critical role in many vaccine formulations. Adjuvants often signal through Toll-like receptor (TLR) pathways, including formulations in licensed vaccines that target TLR4. While TLR4 is predominantly known for responding to lipopolysaccharide (LPS), a component of Gram-negative bacterial membranes, it has been shown to be a receptor for a number of molecular structures, including phospholipids. Therefore, phospholipid-based pharmaceutical formulations might have off-target effects by signaling through TLR4, confounding interpretation of pharmaceutic

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Hussein, Mohammed Abdalla, Noor Eldin Mohamed Ismail, Ahmed H. Mohamed, Rita M. Borik, Ali Abdelaziz Ali, and Yasser O. Mosaad. "Plasma Phospholipids: A Promising Simple Biochemical Parameter to Evaluate COVID-19 Infection Severity." Bioinformatics and Biology Insights 15 (January 2021): 117793222110558. http://dx.doi.org/10.1177/11779322211055891.

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Background: Coronavirus-19 (COVID-19) pandemic is a worldwide public health problem that has been known in China since December 25, 2019. Phospholipids are structural components of the mammalian cytoskeleton and cell membranes. They suppress viral attachment to the plasma membrane and subsequent replication in lung cells. In the virus-infected lung, phospholipids are highly prone to oxidation by reactive oxygen species, leading to the production of oxidized phospholipids (OxPLs). Objective: This study was carried out to explain the correlation between the level of plasma phospholipids in patie

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Soares, Melina, Sameer Syed, Gustavo Barbero, and Philip E. Thorpe. "ANTIBODY-MEDIATED TARGETING OF “INSIDE-OUT” ANIONIC PHOSPHOLIPIDS IN VIRAL DISEASE (47.21)." Journal of Immunology 178, no. 1_Supplement (2007): S70. http://dx.doi.org/10.4049/jimmunol.178.supp.47.21.

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Abstract The anionic phospholipid phosphatidylserine (PS) is found exclusively in the inner leaflet of the plasma membrane of resting mammalian cells. We hypothesized that certain events that occur during virus replication (eg cell activation or membrane rearrangement) would trigger the exposure of anionic phospholipids on the outer surface of virus- infected cells and subsequently on the enveloped viruses that bud out of these virus- infected cells. We further hypothesized that these exposed anionic phospholipids would serve as targets for anti-viral therapy. We demonstrate here that anionic

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PETERS-GOLDEN, Marc, Keli SONG, Teresa MARSHALL, and Thomas BROCK. "Translocation of cytosolic phospholipase A2 to the nuclear envelope elicits topographically localized phospholipid hydrolysis." Biochemical Journal 318, no. 3 (1996): 797–803. http://dx.doi.org/10.1042/bj3180797.

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Cytosolic phospholipase A2 (cPLA2) is a good candidate for mediating the agonist-stimulated release of arachidonic acid (AA) from membrane phospholipids. This enzyme undergoes a Ca2+-dependent translocation from the cytosol to a membrane site in a variety of cell types, and this site has recently been identified as the nuclear envelope in leucocytes. The functional correlate of this finding has not yet been established. The present study was therefore undertaken to determine whether translocation of cPLA2 to the nuclear envelope was associated with localized phospholipid hydrolysis at this sit

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SURETTE, E. Marc, and H. Floyd CHILTON. "The distribution and metabolism of arachidonate-containing phospholipids in cellular nuclei*." Biochemical Journal 330, no. 2 (1998): 915–21. http://dx.doi.org/10.1042/bj3300915.

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The cell nucleus has been identified as a location to which several arachidonic acid-metabolizing enzymes are located in stimulated cells. However, little information exists describing the distribution of arachidonate-containing phospholipids associated with the nucleus or the control of their composition. In this study, nuclei isolated from human monocyte-like THP-1 cells were found to have a distribution of arachidonyl-phospholipids which is markedly different from that of other cellular membranes. THP-1 nuclei which contained 22% of total cellular arachidonate, showed a near equal distribut

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Tones, M. A., N. A. Sharif, and J. N. Hawthorne. "Phospholipid turnover during cell-cycle traverse in synchronous Chinese-hamster ovary cells. Mitogenesis without phosphoinositide breakdown." Biochemical Journal 249, no. 1 (1988): 51–56. http://dx.doi.org/10.1042/bj2490051.

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The turnover of phospholipids was investigated in quiescent serum-starved Chinese-hamster ovary (CHO-K1) cells stimulated to progress through the cell cycle by the addition of dialysed bovine serum. A variety of radiolabelling techniques were employed to study the rapid effects of serum on phospholipids and later events during G1 and S phases of the cell cycle. Pulse-labelling studies using [32P]Pi revealed that there was a stimulation of the synthesis rate of all phospholipids investigated during the initial few hours after serum addition. The greatest stimulation (20-fold) was observed in ph

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