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Dissertations / Theses on the topic 'Theophylline'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Awosika, Ajoritsedere. "Biopharmacy of sustained-release theophylline." Thesis, University of Bradford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.257819.

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2

Purkiss, Ronald. "Bioequivalence of sustained release theophylline formulations." Thesis, Aston University, 1986. http://publications.aston.ac.uk/12472/.

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The bioequivalence of sustained release theophylline formulations, marketed in the United Kingdom, has been investigated in relation to the co-administration of food in both single dose and steady state volunteer studies. The effect of food on pharmacokinetic parameters and their clinical relevance was researched. Experimentation using drug induced modification of gastric motility to ascertain the component influences of the rate of gastric emptying on the absorption of theophylline from sustained release formulations was conducted. Prolongation of time to maximum plasma theophylline concentra

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3

Boer, Jason. "Mechanistic investigation of cytochrome P450 1A2 catalyzed metabolism of 8-alkylxanthines /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/8161.

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4

Zhang, Shuo. "Physical properties and crystallization of theophylline co-crystals." Licentiate thesis, KTH, Transport Phenomena, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-13255.

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<p>This work focuses on the physical properties and crystallization of theophyline co-crystals. Co-crystals of theophylline with oxalic acid, glutaric acid and maleic acid have been investigated.</p><p>The DSC curves of these co-crystals show that their first endothermic peaks are all lower than the melting temperature of theophylline. The decomposition temperature of theophylline – oxalic acid co-crystal is at about 230 °C, determined by DSC together with TGA. After decomposition, the remaining theophylline melts at about 279 °C, which is higher than the known melting temperature of theophyll

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5

Chrystyn, H. "Pharmacodynamics of theophylline in irreversible chronic airflow obstruction." Thesis, University of Bradford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379859.

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6

Chen, Chi. "Engineering of inhalation aerosols combining theophylline and budesonide." Thesis, University of Bradford, 2014. http://hdl.handle.net/10454/14072.

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In asthma therapy, the use of theophylline to prevent bronchial spasm and glucocorticoids to decrease inflammation is widely indicated. Apart from the acute asthma attack oral theophylline is treated for chronic therapy in order to minimize inflammation and to enhance the efficiency of corticosteroids and recover steroids’ anti-inflammatory actions in COPD treatment. The preferred application route for respiratory disease treatment is by inhalation, such as dry powder inhalers (DPI) being the delivery systems of first choice. As shown recently, there is an advantageous effect if the drugs are

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7

Babey, Anna Marie. "Characterization of the time course of the effects of theophylline administration on adenosine receptors in cultured murine neuroblastoma cells." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=28668.

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This thesis examines the effects of continuous theophylline pretreatment on the A$ sb2$ adenosine receptor system in cultured murine neuroblastoma cell lines, which either do or do not also express A$ sb1$ adenosine receptors. N-Ethylcarboxamido adenosine (NECA) stimulates cAMP accumulation and binds to A$ sb2$ receptors in a saturable and biphasic fashion in both types of cell cultures. Sixteen hours of theophylline treatment led to a significant increase in the number of low affinity A$ sb2$ binding sites, as well as a potentiation of NECA-stimulated cAMP accumulation, regardless of whether

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8

LABOULAYE, PHILIPPE. "Les intoxications a la theophylline : indications therapeutiques a propos de trois observations." Amiens, 1989. http://www.theses.fr/1989AMIEM017.

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9

Haarberg, Hans Eirik. "Theophylline IMAGEtags (intracellular multi aptamer genetic tags) the development and evaluation of an RNA reporter system based on the theophylline aptamer /." [Ames, Iowa : Iowa State University], 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:1464205.

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10

Özgarip, Yarkın Bayraktar Oğuz. "Application of Silk Fibroin In Controlled-Release of Theophylline/." [s.l.]: [s.n.], 2004. http://library.iyte.edu.tr/tezler/master/kimyamuh/T000433.pdf.

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11

Dragula, Collen Elizabeth 1964. "A pharmacokinetic study of acrylamide and theophylline in rats." Thesis, The University of Arizona, 1988. http://hdl.handle.net/10150/276847.

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Effects of age, dosage regimen, dose level, and routes of administration on the pharmacokinetics of acrylamide (ACR) and theophylline (TP) in Fischer 344 rats have been studied. ACR treatment consisted of administration of a single subtoxic dose or of multiple doses known to induce neurotoxicity to 5 and 11 week old rats. The effects of age and dosing regimen on the determination of pharmacokinetic parameters were studied. Multiply dosed rats had significantly longer plasma half lives than the singly dosed animals. Clearance values in the plasma were also significantly decreased following mult

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12

JOSROLLAND, MONIQUE. "Les dosages de la theophylline dans les milieux biologiques." Strasbourg 1, 1987. http://www.theses.fr/1987STR10728.

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13

Yao, Caiping. "Comparison of in vitro and in vivo inhibition potencies of fluvoxamine toward CYPIA2 and CYP2C19 /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/7967.

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14

Palmer, Derek Adeyemi. "Sensing of theophylline by enzyme immunoassay coupled with electrochemical detection." Thesis, Loughborough University, 1991. https://dspace.lboro.ac.uk/2134/26872.

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The voltammetry of several substrates and their hydrolysis products for the enzyme alkaline phosphatase (E.C. 3.1.3.1.) were investigated and theophylline-alkaline phosphatase (TH-AP) conjugates were synthesized in order to develop a flow injection electrochemical enzyme immunoassay (FIEEIA) for the antiasthmatic therapeutic drug theophylline.

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15

LERAT, JEAN-PAUL. "Recherche d'une interaction pharmacocinetique entre la norfloxacine et la theophylline." Bordeaux 2, 1988. http://www.theses.fr/1988BOR25089.

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16

Chen, Jye-Daa. "Theophylline disposition in patients with hepatic disease and congestive heart failure." Scholarly Commons, 1992. https://scholarlycommons.pacific.edu/uop_etds/2239.

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The theophylline clearance was evaluated in patients with liver dysfunction and/or congestive heart failure. One hundred and twenty two patients were categorized into four groups; Group I: Liver dysfunction (n=20), Group II: Congestive heart failure (CHF, n=22), Group III: Both liver dysfunction and CHF (n=12), and Group IV: Control group (n=68). The severity of liver dysfunction and CHF were evaluated using Child-Turcotte- Pugh index (CTP) and a Cardiac Function index, respectively. Theophylline clearance was significantly decreased in Groups I, II, and III when compared to the control group;

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17

Mikhail, May Naim. "Design And Evaluation Of Theophylline Monitoring For Home Health Care Patients." Scholarly Commons, 1987. https://scholarlycommons.pacific.edu/uop_etds/3337.

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The purpose of this study was to design, evaluate, and determine the cost benefit of a pharmacokinetic service for home-based patients. Four randomly selected patient populations were used in evaluating the service for six months. The experimental group consisted of 17 patients who were under the care of family practice physicians in private practice and who received pharmacokinetic consultation and monitoring by a pharmacist as a home health care service. The retrospective control consisted of the same 17 patients of the experimental group whose past medical history for a period of six months

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18

Munday, Dale Leslie. "Design, development and evaluation of encapsulated oral controlled release theophylline mini-tablets." Thesis, Rhodes University, 1991. http://hdl.handle.net/10962/d1003255.

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Conventional solid dosage forms often lead to fluctuations which exceed the maximum safe therapeutic level and/or decline below the minimum effective level. It is recognised that many drugs for chronic administration should be administered on a schedule that maintains plasma drug concentration within the therapeutic window. Research in controlled release dosage forms aims at designing a system with a zero-order input (eg, ideally to deliver 8.33% of the dose per hour over a 12 hour duration), producing steady state plasma drug levels. Oral dministration of drugs prepared as a controlled releas

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19

Dupont-Duvalet, Géraldine. "Faisabilite de microgranules de 400 mum par extrusion/spheronisation." Lille 2, 1997. http://www.theses.fr/1997LIL2P261.

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20

Ly, Joseph Pang-Hoi. "Development of an oral microspherical formulation for bimodal in vitro release of theophylline." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ29336.pdf.

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21

Brophy, Conor Jane. "The effect of theophylline on the respiratory and quadriceps femoris muscles in man /." Title page, contents and abstract only, 1992. http://web4.library.adelaide.edu.au/theses/09MD/09mdb873.pdf.

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22

Scally, C. M. "The effect of theophylline upon the immune response to nasal antigen in man." Thesis, Queen's University Belfast, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261934.

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23

Fritz, Kathleen Gary. "Development of a urinary metabolic ratio that reflects systemic theophylline elimination during pregnancy." Scholarly Commons, 1993. https://scholarlycommons.pacific.edu/uop_etds/2245.

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A number of studies have investigated the natural history of asthma in pregnancy. Most of the data suggests that the course of asthma for a given patient is unpredictable. Turner, et al.7 summarize the data from all of the English-language literature of studies on the effect of pregnancy on astha. Of 1054 cases examined, 49% of the asthma conditions remained unchanged, 22% got worst and 29% became better.7 Theophylline has been used safely during pregnancy. A review of the literature by O'Brien, showed that no teratogenic effects were associated with the use of theophylline in 117 cases and am

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24

Buissard, Nathalie. "Ajustement de posologie de la théophylline administrée par voie intra-veineuse à des patients en état de mal asthmatique." Paris 5, 1996. http://www.theses.fr/1996PA05P197.

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25

Oiknine, Michel. "Interactions médicamenteuses de la théophylline." Paris 5, 1988. http://www.theses.fr/1988PA05P144.

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26

BERARD, FLORENCE. "Syndrome de bartter induit : a propos d'un cas." Aix-Marseille 2, 1988. http://www.theses.fr/1988AIX20342.

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27

Yahioglu, Fulya. "The development of a fluoroimmunoassay for theophylline using the fluorescence capillary fill device (FCFD)." Thesis, University of Bath, 1995. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307135.

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28

Attia, Sonia. "Amélioration de l'absorption intestinale de la théophylline : utilisation d'une méthode "ex vivo"." Paris 5, 1996. http://www.theses.fr/1996PA05P124.

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29

Buhecha, Mira Dhiraj. "The development and characterization of theophylline and budesonide co-encapsulated poly (lactic acid) (PLA) nanoparticles." Thesis, University of Brighton, 2016. https://research.brighton.ac.uk/en/studentTheses/a46c129a-c404-4132-b7de-1698dc88cdfa.

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Inhaled drug delivery is ideal for treatment of asthma and chronic obstructive pulmonary disease (COPD) as it allows a local action of the medication at the disease site. Biodegradable polymeric nanoparticles which might allow extended/sustained release of inhaled drugs are synthesized using various methods however; these do not permit high encapsulation efficiency for hydrophilic drugs. The aim of the project was to test the hypothesis that it was possible to develop an efficient method for the co-encapsulation of a hydrophilic and lipophilic drug (theophylline and budesonide respectively) in

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30

Mehta, Bhanvi. "The Formation of Pharmaceutical Co-crystals by Spray Drying. An Investigation into the Chemical and Physical Factors Affecting the Production of Pharmaceutical Co-crystals by Fast Evaporation and Spray Drying." Thesis, University of Bradford, 2016. http://hdl.handle.net/10454/14630.

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Crystal engineering study using spray dryer was performed for scale-up and rapid, continuous crystallisation of co-crystals from solution. The study emphasise on developing co-crystals of two structurally similar compounds, caffeine (CAF) and theophylline (THEO) with various di-carboxylic acids. The incongruently soluble pair of CAF and THEO with di-carboxylic acids acquires large solubility difference which is important to consider for its utility in product development. Based on previous assumption that maleic acid (MAL) elevates CAF’s solubility; solubility of the two similar compounds was

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31

HAKIL, MEHDI. "Degradation de la cafeine par les champignons filamenteux, purification et caracterisation d'une theophylline demethylase d'aspergillus tamarii." Besançon, 1999. http://www.theses.fr/1999BESA2021.

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Les champignons filamenteux sont capables de degrader la cafeine contenue dans la pulpe de cafe ou dans des milieux entierement synthetiques. Les enzymes impliquees dans cette degradation n'ont jamais ete caracterisees a l'etat pur chez les champignons filamenteux. Notre objectif etait de purifier une enzyme impliquee dans la degradation de la cafeine afin de la caracteriser. Sur 20 souches de champignons filamenteux testees, 3 aspergillus et 4 penicillium commune ont ete capables de degrader la cafeine d'un milieu liquide ne contenant pas d'autre source d'azote. Ces 7 souches degradent la caf

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32

Tandt, Ludo Alfons Germaan Luc. "The evaluation of indomethacin and theophylline oral controlled/modified-release dosage forms in vitro-in vivo correlations." Thesis, Rhodes University, 1992. http://hdl.handle.net/10962/d1003272.

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Over the past few decades many researchers have investigated the utility of in vitro - in vivo correlations for the assessment of dosage forms. These investigations are, however, dependent on reproducible dissolution data and well conducted biostudies in order to establish meaningful and robust correlations. Despite the fact that the establishment of such correlations is perhaps idealistic, considerable interest has still been shown in this area of research. Various Controlled/Modified Release Dosage Forms (CMRD's) of theophylline, a weakly basic drug, and indomethacin, a weakly acidic drug, w

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33

Noël, Bernard. "Corrélation des taux salivaires et plasmatiques de théophylline chez l'enfant." Montpellier 1, 1991. http://www.theses.fr/1991MON11205.

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34

Yajid, Fatima. "Effets de l'hypodynamie et de la théophylline sur la respiration mitochondriale de muscles striés squelettiques de rats." Montpellier 1, 1999. http://www.theses.fr/1999MON1T022.

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35

Sullivan, Paul Joseph Gerard. "The effect of treatment with low dose theophylline on the inflammatory response to allergen in atopic asthma." Thesis, University College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362934.

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36

Shearer, Luz-Elena Oropesa. "METHYLXANTHINE LEVELS IN BREAST MILK OF LACTATING WOMEN OF DIFFERENT SOCIOECONOMIC CLASSES (CAFFEINE, THEOBROMINE, PARAXANTHINE, THEOPHYLLINE, ETHNIC)." Thesis, The University of Arizona, 1985. http://hdl.handle.net/10150/275462.

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37

Douriez, Eric. "Mise en place d'une procédure d'établissement de la posologie et de surveillance des effets de différentes formes de théophylline dans trois services hospitaliers, de pédiatrie, de pneumologie et de réanimation néonatale." Paris 5, 1993. http://www.theses.fr/1993PA05P047.

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38

Pellerin, Frédéric. "Electrophysiologie cardiaque et ischémie provoquée dans le territoire de la coronaire droite : incidence de l'injection des phyllines." Montpellier 1, 1991. http://www.theses.fr/1991MON11183.

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39

Acheson, David William Kennedy. "The pharmacokinetics of theophylline and antipyrine and the pharmacogenetics of debrisoquine metabolism in patients with exocrine pancreatic disease." Thesis, Imperial College London, 1988. http://hdl.handle.net/10044/1/46925.

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40

Soderstrom, David. "Fuzzy logic modeling and intelligent sliding mode control techniques for the individualization of theophylline therapy to pediatric patients." Thesis, Georgia Institute of Technology, 1992. http://hdl.handle.net/1853/19097.

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41

Barbosa, Eduardo José. "Avaliação da goma gelana como aglutinante em formulações de pellets contendo teofilina." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/9/9139/tde-28032017-163125/.

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O objetivo deste trabalho foi desenvolver formulações de pellets contendo teofilina, utilizando a goma gelana como aglutinante. Inicialmente, o uso desse polímero foi avaliado em comparação com o PVP. Por meio de delineamento experimental 32 foram analisadas as variáveis aglutinante e diluente. Os pellets obtidos apresentaram resultados satisfatórios na friabilidade e esfericidade. Verificou-se que o diluente exerceu influência significativa na granulometria, de modo que formulações com manitol apresentaram maior formação de pó após a produção. Com relação ao aglutinante sua maior influência f

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42

Parent, Xavier. "Determination de la concentration en forme libre de medicaments antiepileptiques et d'antiasthmatiques dans le serum et la salive." Strasbourg 1, 1992. http://www.theses.fr/1992STR15065.

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43

Van, Nieuwenhuyse Virginie. "Interaction pharmacocinétique entre le cisapride et la théophylline." Paris 5, 1994. http://www.theses.fr/1994PA05P248.

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44

Mauguen, Anne. "Innovations pharmacologiques et galéniques dans le traitement de la crise et de la maladie asthmatique." Paris 5, 1992. http://www.theses.fr/1992PA05P232.

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45

Rakotobe, Ratsimbazafy Voahirana. "Etude pharmacotechnique des gélucires : comportement rhéologie optimisation et mécanisme de libération de dérivés théophylliniques à partir de formes matricielles." Limoges, 1994. http://www.theses.fr/1994LIMO301A.

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46

Walker, Heather M. "A Preliminary Study of the Interaction of Acidic and Basic Drugs Using Ethyl Cellulose Microspheres." University of Toledo Health Science Campus / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=mco1352435064.

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47

SARANG, SANJAY S. "METHACRYLATE AND Ca-ALGINATE POLYMERS AS BARRIER COATINGS FOR PROTECTION AND CONTROLLED RELEASE OF VITAMIN C." University of Cincinnati / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1078246935.

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48

Wu, Hsiu-Jean. "The kinetics of solvent-mediated phase transformations." Diss., The University of Arizona, 1990. http://hdl.handle.net/10150/184981.

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The objectives of this work are to characterize and model the solvent-mediated phase transformation process of theophylline anhydrous crystals to the monohydrate crystals in an aqueous system. In order to model the transformation, the following processes are taken into account: (1) the dissolution kinetics of theophylline anhydrous crystals, (2) the kinetics of the formation of theophylline monohydrate nuclei, and (3) the growth kinetics of the monohydrate crystals. The driving forces for the above processes are determined from the concentration of theophylline in the solution and the solubili

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49

Mohamed, Noha N. A. "Pharmaceutical analysis and in-vitro aerodynamic characterisation of inhaled theophylline formulations containing drug particles prepared by supercritical fluid processing. Chromatographic, spectroscopic, and thermal analysis of micron-sized theophylline particles prepared by supercritical fluid technology and in-vitro evaluation of their performance as inhaled dry powder formulations." Thesis, University of Bradford, 2009. http://hdl.handle.net/10454/4297.

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The aim of this work is to study the in-vitro aerodynamic performance of a new inhaled theophylline formulation prepared by supercritical fluids technique. For the analysis of the output from the in-vitro tests (and further in-vivo tests) a new, fast, sensitive high performance liquid chromatographic (HPLC) method was developed and validated for the determination of theophylline and other related derivatives in aqueous and urine samples using new packing materials (monolithic columns). These columns achieve efficient separation under lower backpressure and shorter time comparing to other

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50

Mohamed, Noha Nahedj Atia. "Pharmaceutical analysis and in-vitro aerodynamic characterisation of inhaled theophylline formulations containing drug particles prepared by supercritical fluid processing : chromatographic, spectroscopic, and thermal analysis of micron-sized theophylline particles prepared by supercritical fluid technology and in-vitro evaluation of their performance as inhaled dry powder formulations." Thesis, University of Bradford, 2009. http://hdl.handle.net/10454/4297.

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The aim of this work is to study the in-vitro aerodynamic performance of a new inhaled theophylline formulation prepared by supercritical fluids technique. For the analysis of the output from the in-vitro tests (and further in-vivo tests) a new, fast, sensitive high performance liquid chromatographic (HPLC) method was developed and validated for the determination of theophylline and other related derivatives in aqueous and urine samples using new packing materials (monolithic columns). These columns achieve efficient separation under lower backpressure and shorter time comparing to other tradi

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