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Journal articles on the topic 'Theophylline'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Tatsis, G., J. Danos, M. Gaga, D. Pantelakis, M. Veslemes, and J. Jordanoglou. "A Single-Blind Crossover Study of Two Different Slow Release Theophylline Preparations." Journal of International Medical Research 16, no. 6 (1988): 452–58. http://dx.doi.org/10.1177/030006058801600607.

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In a single-blind crossover study, two slow release theophylline preparations were evaluated in 18 patients with chronic bronchitis or asthma without cardiac, renal or liver disease. After randomization into two groups, patients were treated, in a crossover study design, with 600 mg choline theophyllinate or 300 mg anhydrous theophylline administered orally every 12 h for 7 days. A 2-day washout period separated the two periods of treatment evaluation. Blood samples in which plasma theophylline concentration was to be measured were taken at 7.30 a.m., 2.00 p.m. and 7.30 p.m. during the last 5

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2

Ali, Tasneem Basheer, Huda Yousef Almomani, Fatima Mahmoud Al-Tarawneh, Maysa Waddah Alwadi, and Ahmad Shaher Suliman. "Physicians' Knowledge of Theophylline Use: A Cross-Sectional Study from Jordan." Jordan Journal of Pharmaceutical Sciences 16, no. 4 (2023): 857–70. http://dx.doi.org/10.35516/jjps.v16i4.1789.

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Objective: This cross-sectional study aims to assess physicians' knowledge regarding theophylline drug and other related characteristics in Jordan. Materials and Method: The study was conducted prospectively among physicians in Jordan. Physicians were interviewed using an online questionnaire consisting of two sections. The first section included demographics and other relevant characteristics, while the second section comprised questions about theophylline drug. Results: A total of 385 participants completed the questionnaire. The majority of participants knew that theophylline is used in cli

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3

Malamatari, Maria. "Inhaled theophylline: old drug new tricks?" International Journal of Basic & Clinical Pharmacology 13, no. 1 (2023): 174–80. http://dx.doi.org/10.18203/2319-2003.ijbcp20233912.

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Theophylline and aminophylline (i.e., the soluble complex of theophylline with ethylenediamine) have been used in the treatment of respiratory diseases such as asthma and chronic obstructive pulmonary disease for more than 90 years. Theophylline’s narrow therapeutic index and side effects, as well as the discovery of more potent and safer bronchodilators, made it to fall out of favour with healthcare professionals and patients. New scientific knowledge on the molecular mechanism of action of theophylline, along with increasing clinical evidence suggest that theophylline should be exploited as

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4

Boner, A. L., G. De Stefano, G. Vallone, M. Plebani, and P. Ventura. "Absolute and Relative Bioavailability of a Slow Release Theophylline Preparation in Asthmatic Children." Journal of International Medical Research 15, no. 5 (1987): 282–92. http://dx.doi.org/10.1177/030006058701500504.

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This study was carried out on 14 asthmatic childen aged 7–13 years. They all received three preparations (aminophylline by intravenous infusion, lysine theophyllinate orally in solution and slow release theophylline orally as capsules) in a single dose of 100 mg active ingredient in a crossover design. Plasma theophylline concentrations, determined by a fluorescent polarization immunoassay, were evaluated both by compartmental and non-compartmental analysis. After administration of slow release theophylline, its maximum plasma concentration and the time needed to reach this were (± SD) 3.19 ±

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5

BRODWALL, ERLING K. "The Resorption of Theophyllamine (Theophylline Ethylenediamine)." Acta Medica Scandinavica 146, no. 2 (2009): 123–26. http://dx.doi.org/10.1111/j.0954-6820.1953.tb10222.x.

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6

Nolte, Matthias, Ingo Pantenburg, and Gerd Meyer. "Konkurrierende Liganden: Theophyllin als nicht- und stark koordinierender Ligand in Quecksilber(II)-Komplexen / Competing Ligands: Theophylline as Non- and Strongly Coordinating Ligand in Mercury(II) Complexes." Zeitschrift für Naturforschung B 61, no. 6 (2006): 758–65. http://dx.doi.org/10.1515/znb-2006-0617.

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[{Hg(CF3)2}(ThpH)(H2O)](H2O) (1), [{Hg4(Thp)4}(ClO4)4(H2O)8](H2O)4 (2), [{Hg(ThpH)2} (NO3)](NO3) (3) and {Hg(Thp)Cl}(H2O) (4) (ThpH = theophylline, C7H8N4O2) have been synthesized by slow evaporation of aqueous solutions of the mercuric salts Hg(CF3)2, Hg(ClO4)2, Hg(NO3)2, or HgCl2 and theophylline. Their crystal structures were determined on the basis of single crystal X-ray data. The coordination polymers 1 and 2 crystallize with triclinic symmetry, P1̅ (no. 2), with a = 468.8(2), b = 1256.4(5), c = 1445.5(6) pm, α = 67.15(3), β = 89.21(3), γ = 89.40(3)° and a = 833.6(1), b = 1862.7(2), c =

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7

Wang, L. C., S. F. Man, and A. N. Belcastro. "Metabolic and hormonal responses in theophylline-increased cold resistance in males." Journal of Applied Physiology 63, no. 2 (1987): 589–96. http://dx.doi.org/10.1152/jappl.1987.63.2.589.

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The effects of theophylline (a phosphodiesterase inhibitor-adenosine receptor antagonist) and substrate feeding (Ensure, 250 kcal/235 ml) on cold resistance were studied in seminude males undertaking submaximal (50% maximum O2 consumption), intermittent (34% of total time) exercise in the cold (-5 to 15 degrees C, individually adjusted) for 3 h. Each subject (n = 7) served as his own control and was tested on a weekly schedule. Under control treatment, rectal temperature (Tre) decreased by 0.9 degrees C to approximately 36.2 degrees C after cold exposure, whereas under theophylline and Ensure,

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8

Szarłowicz, Jakub, Michał Mazur, Dorota Waz, et al. "Theophylline Revisited. Mechanisms, Challenges, and New Horizons." Quality in Sport 37 (January 2, 2025): 57009. https://doi.org/10.12775/qs.2025.37.57009.

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Introduction and Purpose Theophylline, used for over a century in asthma and COPD treatment, provides anti-inflammatory and bronchodilatory effects via phosphodiesterase inhibition and adenosine receptor antagonism. This review examines its mechanisms, clinical uses, and emerging applications. Materials and Methods A detailed analysis of 23 peer-reviewed studies from scientific databases, including PubMed, focused on theophylline’s pharmacokinetics, pharmacodynamics, clinical safety, and novel applications in areas such as immunomodulation, metabolic disorders, and regenerative medicine. Resul

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9

Jeong, Chan Su, Soon Chul Hwang, Daniel W. Jones, Hwan Sun Ryu, Kieho Sohn, and Charles D. Sands. "Theophylline Disposition in Korean Patients with Congestive Heart Failure." Annals of Pharmacotherapy 28, no. 3 (1994): 396–401. http://dx.doi.org/10.1177/106002809402800319.

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OBJECTIVE: This study proposed to determine the systemic disposition on of theophyllinein Korean adult patients during decompensated congestive heart failure compared with disposition after recovery. DESIGN: An experimental, prospective, self-controlled, non randomized design was used. SETTING: The study was performed in a general communityhospital located in Pusan, Korea. PATIENTS: Eight nonsmoking elderly Korean patients with decompensated congestive heart failure presenting to the emergency department were included in the study. Consecutive patients who met entrance criteria were selected.

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10

Spinler, Sarah A., Arnold Gammaitoni, Scott L. Charland, and Jodie Hurwitz. "Propafenone‐Theophylline Interaction." Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 13, no. 1 (1993): 68–71. http://dx.doi.org/10.1002/j.1875-9114.1993.tb02692.x.

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A 63‐year‐old man with ventricular tachycardia (VT) refractory to drug therapy was admitted for surgical ablation of the VT with coronary artery bypass graft surgery. He developed increased theophylline concentrations with decreased calculated theophylline clearance after propafenone therapy for recurrent VT was initiated. Within 1 day after the addition of propafenone 150 mg every 8 hours to a drug regimen that included theophylline sustained‐release tablets 300 mg every 12 hours, the patient demonstrated increased theophylline serum concentrations and decreased calculated theophylline cleara

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11

Torrent, Josep, Iñaki Izquierdo, Ricardo Cabezas, and Francesc Jané. "Theophylline-Isoniazid Interaction." DICP 23, no. 2 (1989): 143–45. http://dx.doi.org/10.1177/106002808902300208.

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Drugs influencing hepatic microsomal enzyme systems, such as isoniazid, may affect the elimination pattern of theophylline. The case reported here refers to an adult female patient with a history of chronic asthma and intestinal tuberculosis who, during isoniazid therapy, presented with theophylline plasma concentrations above the therapeutic range and developed toxic symptoms. The initial episode of theophylline toxicity occurred after one month of coadministering isoniazid 300 mg/d and theophylline 350 mg bid. The theophylline plasma concentration during this episode was 24.1 μg/mL and was a

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12

Ahsan, Ullah, Umair Muhammad, Usama Muhammad, et al. "Landscaping of Entire Range of Non-covalent interactions in Theophylline monohydrate and anhydrous Theophylline through Hirshfeld surface analysis." Global Scientific and Academic Research Journal of Multidisciplinary Studies 3, no. 12 (2024): 198–207. https://doi.org/10.5281/zenodo.14582360.

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<em>Theophylline monohydrate and polymorphs of anhydrous theophylline are being compared. Crystallographic data was obtained using the Cambridge structural data source. In this investigation, 1,3-Dimethyl-3,7-dihydro-1H-purine-2,6-dione monohydrate (Ref-code: THEOPH) and 1,3-Dimethyl-3,7-dihydro-1H-purine-2,6-dione (Ref-code: BAPLOT) are chosen. Hirshfeld surface tools were used to visualize the different types of intermolecular interactions throughout the crystal range of theophylline monohydrate and polymorphs of anhydrous theophylline. The fundamental distinction between theophylline m

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13

Hagley, Michael T., Sheldon M. Traeger, and Hugh Schuckman. "Pronounced Metabolic Response to Modest Theophylline Overdose." Annals of Pharmacotherapy 28, no. 2 (1994): 195–96. http://dx.doi.org/10.1177/106002809402800207.

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OBJECTIVE: To describe a patient who developed significant metabolic abnormalities in response to a low-level theophylline ingestion. CASE SUMMARY: An 18-year-old man was examined after ingesting theophylline 3 g in a suicide attempt. Although his peak theophylline concentration was 157 μmol/L (28.2 μg/mL), it was associated with significant leukocytosis, hypokalemia, hypomagnesemia, hypophosphatemia, hyperglycemia, and lactic acidosis. These abnormalities have been previously associated with theophylline intoxication, but only in conjunction with much higher peak concentrations of theophyllin

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14

Matuschka, Paul R., and Richard S. Vissing. "Clinafloxacin-Theophylline Drug Interaction." Annals of Pharmacotherapy 29, no. 4 (1995): 378–80. http://dx.doi.org/10.1177/106002809502900407.

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Objective: To report an apparent pharmacokinetic interaction between clinafloxacin and theophylline in a patient with chronic obstructive pulmonary disease (COPD). Case Summary: A patient with a history of COPD was admitted for a fracture of the right femoral neck. Admission medications included extended-release theophylline 400 mg bid. The initial serum theophylline concentration was 81.03 µmol/L (normal 55—110). A subsequent concentration was subtherapeutic (46.62 µmol/L) and the theophylline dosage was increased to 300 mg tid. Therapeutic steady-state concentrations were achieved. The patie

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15

Rees, Sharon. "THEOPHYLLINE." Journal of Prescribing Practice 3, no. 2 (2021): 52. http://dx.doi.org/10.12968/jprp.2021.3.2.52.

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16

&NA;. "Theophylline." Reactions Weekly &NA;, no. 728 (1998): 12. http://dx.doi.org/10.2165/00128415-199807280-00041.

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17

&NA;. "Theophylline." Reactions Weekly &NA;, no. 1167 (2007): 26. http://dx.doi.org/10.2165/00128415-200711670-00078.

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18

&NA;. "Theophylline." Reactions Weekly &NA;, no. 1152 (2007): 25–26. http://dx.doi.org/10.2165/00128415-200711520-00078.

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19

&NA;. "Theophylline." Reactions Weekly &NA;, no. 1371 (2011): 35–36. http://dx.doi.org/10.2165/00128415-201113710-00130.

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20

&NA;. "Theophylline." Reactions Weekly &NA;, no. 533 (1995): 11. http://dx.doi.org/10.2165/00128415-199505330-00042.

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21

&NA;. "Theophylline." Reactions Weekly &NA;, no. 544 (1995): 12. http://dx.doi.org/10.2165/00128415-199505440-00035.

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22

Napier‐Flood, Fiona E., and Brian R. Creese. "Theophylline." Medical Journal of Australia 162, no. 10 (1995): 548–50. http://dx.doi.org/10.5694/j.1326-5377.1995.tb138519.x.

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23

&NA;. "Theophylline." Reactions Weekly &NA;, no. 433 (1993): 11. http://dx.doi.org/10.2165/00128415-199304330-00048.

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24

&NA;. "Theophylline." Reactions Weekly &NA;, no. 446 (1993): 12. http://dx.doi.org/10.2165/00128415-199304460-00053.

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25

&NA;. "Theophylline." Reactions Weekly &NA;, no. 452 (1993): 11. http://dx.doi.org/10.2165/00128415-199304520-00051.

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26

&NA;. "Theophylline." Reactions Weekly &NA;, no. 458 (1993): 11. http://dx.doi.org/10.2165/00128415-199304580-00057.

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27

Barnes, Peter J. "Theophylline." Pharmaceuticals 3, no. 3 (2010): 725–47. http://dx.doi.org/10.3390/ph3030725.

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28

&NA;. "Theophylline." Reactions Weekly &NA;, no. 621 (1996): 12. http://dx.doi.org/10.2165/00128415-199606210-00041.

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29

&NA;. "Theophylline." Reactions Weekly &NA;, no. 627 (1996): 12. http://dx.doi.org/10.2165/00128415-199606270-00036.

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30

Weinberger, Miles M. "Theophylline." Immunology and Allergy Clinics of North America 10, no. 3 (1990): 559–76. http://dx.doi.org/10.1016/s0889-8561(22)00295-8.

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31

Milgrom, Henry. "THEOPHYLLINE." Immunology and Allergy Clinics of North America 13, no. 4 (1993): 819–38. http://dx.doi.org/10.1016/s0889-8561(22)00662-2.

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32

&NA;. "Theophylline." Reactions Weekly &NA;, no. 791 (2000): 12. http://dx.doi.org/10.2165/00128415-200007910-00029.

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33

&NA;. "Theophylline." Reactions Weekly &NA;, no. 369 (1991): 11. http://dx.doi.org/10.2165/00128415-199103690-00060.

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34

&NA;. "Theophylline." Reactions Weekly &NA;, no. 371 (1991): 12. http://dx.doi.org/10.2165/00128415-199103710-00061.

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35

&NA;. "Theophylline." Reactions Weekly &NA;, no. 374 (1991): 8. http://dx.doi.org/10.2165/00128415-199103740-00042.

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36

&NA;. "Theophylline." Reactions Weekly &NA;, no. 380 (1991): 8. http://dx.doi.org/10.2165/00128415-199103800-00041.

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37

&NA;. "Theophylline." Reactions Weekly &NA;, no. 384 (1992): 12. http://dx.doi.org/10.2165/00128415-199203840-00065.

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38

&NA;. "Theophylline." Reactions Weekly &NA;, no. 403 (1992): 8. http://dx.doi.org/10.2165/00128415-199204030-00034.

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39

&NA;. "Theophylline." Reactions Weekly &NA;, no. 1199 (2008): 44. http://dx.doi.org/10.2165/00128415-200811990-00134.

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40

&NA;. "Theophylline." Reactions Weekly &NA;, no. 1214 (2008): 29. http://dx.doi.org/10.2165/00128415-200812140-00084.

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41

Markham, Anthony, and Diana Faulds. "Theophylline." Drugs 56, no. 6 (1998): 1081–91. http://dx.doi.org/10.2165/00003495-199856060-00018.

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42

&NA;. "Theophylline." Reactions Weekly &NA;, no. 915 (2002): 12. http://dx.doi.org/10.2165/00128415-200209150-00040.

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43

&NA;. "Theophylline." Reactions Weekly &NA;, no. 296 (1990): 7. http://dx.doi.org/10.2165/00128415-199002960-00032.

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44

&NA;. "Theophylline." Reactions Weekly &NA;, no. 307 (1990): 7. http://dx.doi.org/10.2165/00128415-199003070-00034.

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45

&NA;. "Theophylline." Reactions Weekly &NA;, no. 313 (1990): 8. http://dx.doi.org/10.2165/00128415-199003130-00042.

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46

&NA;. "Theophylline." Reactions Weekly &NA;, no. 328 (1990): 11. http://dx.doi.org/10.2165/00128415-199003280-00059.

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47

&NA;. "Theophylline." Reactions Weekly &NA;, no. 341 (1991): 11. http://dx.doi.org/10.2165/00128415-199103410-00067.

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48

&NA;. "Theophylline." Reactions Weekly &NA;, no. 347 (1991): 7. http://dx.doi.org/10.2165/00128415-199103470-00033.

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49

&NA;. "Theophylline." Reactions Weekly &NA;, no. 356 (1991): 8. http://dx.doi.org/10.2165/00128415-199103560-00037.

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50

&NA;. "Theophylline." Reactions Weekly &NA;, no. 359 (1991): 8. http://dx.doi.org/10.2165/00128415-199103590-00042.

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