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Dissertations / Theses on the topic 'Therapeutic and preventive complex'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Kotelban, A. V. "Microbiological assessment of a complex of therapeutic-preventive measures concerning chronic catarrhal gingivitis in children against diabetes mellitus." Thesis, БДМУ, 2020. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/17827.

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2

Potter, Kathleen. "The effects of long-term homocysteine-lowering treatment with folic acid, vitamin B6 and Vitamin B12 on vascular structure and function in stroke." University of Western Australia. School of Medicine and Pharmacology, 2009. http://theses.library.uwa.edu.au/adt-WU2010.0020.

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[Truncated abstract] An elevated total plasma homocysteine concentration (tHcy) is associated with an increased risk of myocardial infarction and ischemic stroke. Folic acid, vitamin B6 and B12 supplements significantly reduce tHcy even in people who are not overtly vitamin deficient. If homocysteine is a causal risk factor for atherothrombotic events, treatment with B-vitamins might prove a simple and cost-effective means to reduce cardiovascular risk. However, it remains unclear whether elevated tHcy causes atherosclerosis or is simply a risk marker. To prove that homocysteine is a modifiabl

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3

Ferreira, Rita Marisa Nogueira. "Preventive and therapeutic strategies for pulmonary arterial hypertension." Doctoral thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/22467.

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Doutoramento em Bioquímica<br>A hipertensão arterial pulmonar (HAP) é uma doença grave, caracterizada por remodelação progressiva da vasculatura pulmonar, frequentemente culminando em insuficiência do ventrículo direito (VD) e morte prematura. Apesar do progresso que tem sido feito nos últimos anos em termos de opções de tratamento, a HAP permanece uma doença incurável, com um mau prognóstico e uma elevada taxa de mortalidade. No presente trabalho, pretendeu-se explorar o potencial de diferentes abordagens preventivas e terapêuticas na HAP experimental. Para isso, três estudos experimentais fo

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4

Long, Elisa Frances. "Economic analysis of preventive and therapeutic HIV interventions /." May be available electronically:, 2008. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.

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5

Wang, Ning Michael, and 王宁. "The preventive and curative potential of berberine and coptis on humanhepatocellular carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48079637.

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Hepatocellular carcinoma (HCC) is the primary cancer of liver. It is the fifth common malignant tumor in men while seventh common in women. Aetiology of HCC is complex; however, it is now believed that sustained chronic liver injury and fibrosis are critically involved in the development of HCC. Prevention and treatment of HCC is far from desirable and prognosis remains poor. Coptis is a Chinese herbal Medicine which has been used for more than thousands years for clearing heats, dampness and toxics. Recently, studies from our group reported the hepatoprotective effect of Coptis and its ma

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Cheng, Ka-wing, and 鄭家榮. "Preventive potential and mechanism of dietary phenolics on the formation of mutagenic heterocyclic amines." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B4284177X.

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The Best PhD Thesis in the Faculties of Dentistry, Engineering, Medicine and Science (University of Hong Kong), Li Ka Shing Prize,2008-2009<br>published_or_final_version<br>Biological Sciences<br>Doctoral<br>Doctor of Philosophy

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7

Saxena, Sarah. "Preventive and therapeutic physio-pathological aspects of peri-operative neurocognitive disorders." Electronic Thesis or Diss., Université de Lille (2022-....), 2022. http://www.theses.fr/2022ULILS034.

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Les troubles neurocognitifs représentent une complication post-opératoire majeure dont l'étiologie est restée longtemps spéculative. Ce n'est que récemment qu'une cascade inflammatoire, menant à l'activation des microglies, a été identifiée et proposée. Dans ce travail, nous avons voulu éclaircir ces mécanismes responsables des troubles cognitifs post-opératoires selon les deux versants, clinique (patients humains) et pré-clinique (modèles murins) qui nous étaient accessibles.Dans l'étude clinique, l'influence des habitudes de vie sur la prévalence des troubles neurocognitifs péri-opératoires

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8

Copeland, Lauren. "Understanding the therapeutic process : mechanisms of motivational interviewing in weight loss maintenance." Thesis, Cardiff University, 2015. http://orca.cf.ac.uk/73303/.

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Background Nearly a quarter of UK adults are obese representing a significant public health problem. Motivational interviewing (MI) may be effective in helping people to lose weight. Planning could be a mechanism of action which is related to outcome. The aim is to define the types of planning talk used by clients during an MI session and examine their relation to weight loss maintenance (WLM) outcomes. Also to examine the skills the therapist used prior to a client talking about planning. Methods To define planning talk a literature review was conducted and an expert group listened to recorde

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9

McAleer, Eileen. "A phenomenological exploration of therapeutic experiences of the transpersonal." Thesis, Liverpool John Moores University, 2008. http://researchonline.ljmu.ac.uk/5864/.

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10

West, Jennifer Inge. "Moving to Heal: Women's Experiences of Therapeutic Yoga after Complex Trauma." Thesis, Boston College, 2011. http://hdl.handle.net/2345/2460.

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Thesis advisor: Belle Liang<br>The study of treatments for complex posttraumatic stress disorder (CPTSD), especially in cases of chronic childhood abuse, has revealed that traditional trauma treatments often lack success due to the complexity of symptom presentation. CPTSD often manifests as a lack of integration between the self and the body. While certain coping strategies used by survivors during the trauma experiences, such as dissociation, may be adaptive in the short-term, prolonged use posttrauma comes at a cost--resulting in a loss of awareness of one's emotional and physical being in

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11

Ourri, Benjamin. "Complex molecular architectures for the recognition of therapeutic bio(macro)molecules." Thesis, Lyon, 2020. http://www.theses.fr/2020LYSE1001/document.

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La reconnaissance de biomolécules dans des milieux biologiques complexes est un réel défi pour les chimistes et les biologistes, associé à des enjeux médicaux majeurs. Face à cette problématique, le chimiste peut choisir d’utiliser des molécules désignées par ses soins, ou encore de sélectionner et d’utiliser directement des structures commerciales ou naturelles. Suivant cette dernière approche, les dendrigrafts de lysines (DGL) ont montré une neutralisation des héparines de différentes tailles supérieures à l’action de la protamine, le seul médicament autorisé en cas de surdosage de l’anticoa

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12

Eyre, Robert W. "Complex statistical modelling of socio-economic variables in public health." Thesis, University of Warwick, 2018. http://wrap.warwick.ac.uk/106563/.

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The statistical inference of socio-economic variables in public health is key to the design of interventions to address the many health inequalities that exist across the world. However, such inferences are achieved commonly using a small standardised library of statistical methods. Meanwhile other fields such as computer science and systems biology have seen the development of many new methods allowing for more varied and useful analyses. Here we present analyses in three important contextual areas of socio-economic variables in public health, bringing in modern and sophisticated methods in o

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13

Manning, Vivien. "A qualitative study of self-perception in the context of complex post traumatic stress disorder and the helping relationship." Thesis, University of Essex, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268703.

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14

Manning, Moriah Nessia. "An Exploitation of Art in the Treatment of Complex Trauma and the Therapeutic Relationship." Digital Commons at Loyola Marymount University and Loyola Law School, 2012. https://digitalcommons.lmu.edu/etd/112.

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This research investigates the therapeutic relationship in the treatment process of complex trauma with children under the age of five. The researcher was the subject of the research, based on her experiences in a practicum placement that was focused on early intervention for young children. This research was an art-based inquiry, and the majority of data was gathered from the researcher’s engagement in the art making processes in response, reflection and observation of the therapeutic relationship. Three different perspectives of data where analyzed for themes in order to aid the researcher i

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Liang, Ning. "Regulation of YAP by mTOR and autophagy reveals a therapeutic target of Tuberous Sclerosis Complex." Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05T055/document.

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La sclérose tubéreuse complexe (TSC) est une maladie génétique caractérisée par une croissance des hamartomes dans différents organes y compris le cerveau, les reins, les poumons, la peau et le cœur. Ces lésions sont des sources de morbidité et de mortalité chez les patients TSC, car ils peuvent provoquerl’ épilepsie, l’autisme, le retard de développement et l’insuffisance rénale et pulmonaire. Les causes connues de TSC sont la perte de la fonction et les mutations des gènes TSC1 et TSC2. La majorité des lésions TSC contient plusieurs types cellulaires de la lignée mésenchymateuse, comme dans

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16

Mulder-Van, Staden Sune. "Diode laser as an additional therapeutic measure in reducing red complex bacteria in chronic periodontitis." University of the Western Cape, 2016. http://hdl.handle.net/11394/5609.

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Magister Chirurgiae Dentium - MChD<br>This mini-thesis assessed whether a diode laser with a wavelength of 810 ± 10nm can be utilized as an adjunct to conventional management (i.e. scaling, root planing and polishing) of chronic periodontitis during initial phase therapy. Ethical approval and study registration (Reg no: 14/9/6) was finalized prior to commencement of the study. A split mouth randomised control trial was performed on 25 participants (who presented at the Oral Medicine and Periodontology Department of the University of the Western Cape) diagnosed with active, chronic periodontiti

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17

Ward, Nathan Patrick. "Therapeutic Modulation of Cancer Metabolism with Dichloroacetate and Metformin." Scholar Commons, 2017. http://scholarcommons.usf.edu/etd/6778.

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The robust glycolytic metabolism of glioblastoma multiforme (GBM) has proven them susceptible to increases in oxidative metabolism induced by the pyruvate mimetic dichloroacetate (DCA). Recent reports demonstrate that the anti-diabetic drug metformin enhances the damaging oxidative stress associated with DCA treatment in cancer cells. We sought to elucidate the role of metformin’s reported activity as a mitochondrial complex I inhibitor in the enhancement of DCA cytotoxicity in the VM-M3 model of GBM. We demonstrated that metformin potentiated DCA-induced superoxide production and that this wa

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18

Penney, Claire Philippa. "'Creative risk' : an IPA study of psychologist's experiences of, and perspectives about, working with substance misusers with histories of complex trauma." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/9945.

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Background: A history of complex trauma alters basic self-structure, attachment system and core areas of interpersonal functioning and relationships. There is increasing recognition of the high proportions of complex trauma histories within substance misusers and limited research into the sequelae of complex trauma, particularly in relation to comorbid complex trauma and substance misuse. There is a distinct lack of adequate theory and guidelines for treatment. Research Aim: to explore psychologist’s experiences of and perspectives about their work with substance misusers with a history of com

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19

Jones, Greg Gordon. "The SHOC2 phosphatase complex as a therapeutic target for ERK pathway inhibition in RAS-driven tumors." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10060157/.

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Targeted inhibition of the ERK-MAPK pathway, upregulated in the majority of human cancers, has been hindered in the clinic by drug resistance and on-target toxicity. The MRAS-SHOC2-PP1 complex plays a key, but underexplored role in RAF-ERK pathway activation, by dephosphorylating a critical inhibitory site on RAF-kinases. In this body of work we present a preferential requirement for the SHOC2-phosphatase complex, specifically for Receptor Tyrosine Kinase (RTK), and anchorage-independent (tumorigenic) growth stimulated ERK-activation. We highlight that this context-dependent signalling bias ha

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20

Errico, Mary J. "The Cyclodextrin-Perfluorinated Surfactant Host-Guest Complex: Fundamental Studies for Potential Environmental Remediation and Therapeutic Applications." FIU Digital Commons, 2018. https://digitalcommons.fiu.edu/etd/3758.

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Perfluoroalkyl substances (PFASs) are contaminants of emerging concern, and have been detected in drinking water, wildlife, humans, and the environment. Cyclodextrins (CDs), cyclic sugars composed of glucose monomers, are proposed as a potential remediation strategy. CDs can form host-guest complexes with hydrophobic molecules; this complexation could be capitalized on for PFAS removal and sequestration. These dissertation projects aim to study the fundamental host-guest interactions between a variety of PFASs and CDs for eventual applications in environmental and biological remediation. 1D an

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21

Saab-Estephan, Marie-Belle. "Rheology and photonics of complex biological systems." Thesis, Montpellier 2, 2010. http://www.theses.fr/2010MON20043.

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La rhéologie et la photonique de divers systèmes biologiques complexes allant des protéines jusqu'aux bactéries et cellules ont été étudiées dans cette thèse. Ces travaux se basent sur deux grands thèmes, où le premier traite la modification des surfaces solides avec des molécules biologiques tandis que le second se concentre sur l'étude des effets des différentes drogues sur des cellules malignes, et non malignes par des techniques microscopiques complémentaires. Dans ce travail, des matrices orientées de films de polyélectrolytes/membrane pourpre ont été produites et étudiées en fonction de

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22

NEGRAO, JOSE A. de S. "Efeitos do Er:YAG laser na cirurgia periapical microscopia eletronica de varredura." reponame:Repositório Institucional do IPEN, 2001. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10927.

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Made available in DSpace on 2014-10-09T12:45:40Z (GMT). No. of bitstreams: 0<br>Made available in DSpace on 2014-10-09T14:08:26Z (GMT). No. of bitstreams: 1 07608.pdf: 2806838 bytes, checksum: c87c4e84bff5fffef152012c504c6fe7 (MD5)<br>Dissertacao (Mestrado Profissionalizante em Lasers em Odontologia<br>IPEN/D-MPLO<br>Instituto de Pesquisas Energeticas e Nucleares, IPEN/CNEN-SP; Faculdade de Odontologia, Universidade de Sao Paulo

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Albtoush, Nansy. "Inhibiting the Function of TSG-6 in Inflammatory Models as a Possible Therapeutic Intervention." Cleveland State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=csu1544060182841309.

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24

Mizutani, Hoshito. "Immediate and Short-Term Effects of Kinesio® Taping on Lower Trunk Range of Motion in Division I Athletes." PDXScholar, 2016. https://pdxscholar.library.pdx.edu/open_access_etds/3377.

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Low back pain (LBP) is a common health problem that contributes to the high cost of health care. Improvement in trunk range of motion has been considered to be an important factor in ameliorating the symptoms of LBP. Kinesio® taping is a prominent therapeutic modality commonly used in the variety of populations for treating musculoskeletal conditions. However, previous research on the efficacy of Kinesio® taping for LBP is limited. The purpose of this study was to investigate the immediate and short-term effects of Kinesio® taping with the muscle inhibition technique on active trunk flexion ra

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25

Raju, Ravikiran. "Where Proteins Go to Die: Elucidating the Physiological and Therapeutic Significance of the Clp Protease Complex in Mycobacterium Tuberculosis." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10501.

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Microbiologists have long focused on transcription as a main source of physiological regulation in bacterial adaptation. However, the time scale on which certain cellular responses must be coordinated dictates that a more rapid system be in place to deal with sudden environmental stresses. In eukaryotes, understanding the proteasome and ubiquitin-tagging has led to an appreciation for protein turnover as a mechanism for rapid adaptation. Like eukaryotes, bacteria possess several proteolytic complexes that degrade proteins into smaller polypeptides and amino acids. These enzymes were discovered

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Thompson, Nicolyn. "Complex immunophenotyping stratifies patients with primary and secondary Sjögren's syndrome into distinct clinically relevant groups with potential therapeutic implications." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10056217/.

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Sjögren’s syndrome (SS) and systemic lupus erythematosus (SLE) are distinct autoimmune rheumatic diseases (ARD) characterised by shared clinical features and immune abnormalities. A proportion of 15-20% of patients with SLE also have features of SS, manifesting as an overlap ARD called secondary SS associated with SLE (SS/SLE). Both SLE and SS are B cell driven diseases, with a recognised female predominance. SS is characterised by distinctive chronic inflammatory process leading to destruction of the exocrine glands orchestrated by T and B lymphocytes, dendritic cells (DCs), macrophages and

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27

Sun, Yong. "Reliability prediction of complex repairable systems : an engineering approach." Queensland University of Technology, 2006. http://eprints.qut.edu.au/16273/.

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This research has developed several models and methodologies with the aim of improving the accuracy and applicability of reliability predictions for complex repairable systems. A repairable system is usually defined as one that will be repaired to recover its functions after each failure. Physical assets such as machines, buildings, vehicles are often repairable. Optimal maintenance strategies require the prediction of the reliability of complex repairable systems accurately. Numerous models and methods have been developed for predicting system reliability. After an extensive literature review

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Manfroni, Antje. "An exploration of the role of the therapeutic relationship in the treatment of complex trauma : a psychodynamic-phenomenological case study." Thesis, Stellenbosch : Stellenbosch University, 2007. http://hdl.handle.net/10019.1/20447.

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Thesis (MA)--University of Stellenbosch, 2008.<br>ENGLISH ABSTRACT: Sometimes it is not entirely clear why certain clients improve. Critical clinical ingredients which may have led to this improvement or recovery are hard to identify and describe and decisions about therapeutic interventions often appear to be intuitive rather than following a strict modus operandi. This is true particularly if refractory or chronic cases start to improve and maintain this improvement. Refractory and chronic cases are the norm amongst clients suffering from complex, chronic trauma, also termed complex PT

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Sun, Yong. "Reliability prediction of complex repairable systems : an engineering approach." Thesis, Queensland University of Technology, 2006. https://eprints.qut.edu.au/16273/1/Yong_Sun_Thesis.pdf.

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This research has developed several models and methodologies with the aim of improving the accuracy and applicability of reliability predictions for complex repairable systems. A repairable system is usually defined as one that will be repaired to recover its functions after each failure. Physical assets such as machines, buildings, vehicles are often repairable. Optimal maintenance strategies require the prediction of the reliability of complex repairable systems accurately. Numerous models and methods have been developed for predicting system reliability. After an extensive literature review

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30

Kanthabalan, Ana Abhiramy. "The evaluation of a novel imaging-based complex diagnostic and therapeutic pathway intervention for men who fail radiotherapy for prostate cancer." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10057034/.

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Background: One-third of men may experience biochemical failure by 8 years following radical radiotherapy for prostate cancer. Focal salvage therapy (FST) may offer further curative treatment. Before FST, distant disease must be ruled-out and intra-prostatic disease must be accurately detected and characterised. Aim: The aim of this thesis was to evaluate novel diagnostic and staging techniques and outcomes of focal salvage treatments for radiorecurrent prostate cancer. Methods: Both retrospective and prospective data will be presented. A retrospective analysis was conducted to compare a) Bone

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31

Sirimanne, Chand Rekha. "The evolving relevance and the therapeutic value of the ethico-psychological perspective of the mind-body complex and meditation in Theravāda Buddhism." Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/23260.

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This research investigates the evolving relevance of Buddhism in the contemporary West and the full potential of the therapeutic value of the ethico-psychological perspective of the mind-body complex and meditation in Theravāda Buddhism. This influence encompasses its ethics, psychology and philosophy, and has given rise to a vibrant socially engaged Buddhism with its roots in traditional Buddhist societies but with a distinct Western character. Buddhism offering a different psychological, ethical, phenomenological perspective and a soteriology and the West its scholarship and analytical appro

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Alexandrou, Estella. "The therapeutic effect of LIF in EAE-associated axonal injury." Connect to thesis, 2009. http://repository.unimelb.edu.au/10187/5514.

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Axonal degeneration is a major pathological feature of the central nervous system (CNS) inflammatory demyelinating disease multiple sclerosis (MS). This axonal degeneration has major consequences, as functional axonal regeneration in the CNS is largely absent. Cumulative axonal degeneration is the likely cause of the majority of progressive MS-related disability, and therefore, the need for novel neuroprotective therapies for MS exists. Experimental autoimmune encephalomyelitis (EAE), an animal model of MS pathology, also produces axonal injury. In particular, the optic nerve and spinal cord

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Buckley, Deirdre Maria. "Exploration of the changing relationship with shame and guilt for survivors of complex trauma whilst accessing therapy : a research portfolio." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/26046.

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Aims: The experience of abuse in childhood can lead to psychological distress later in life. In particular the impact of trauma on the development of the self can render survivors more vulnerable to chronic feelings of shame and guilt. The aims of this research portfolio are twofold. First, a systematic review examines the impact of therapeutic interventions on depression outcomes for survivors of Childhood Sexual Abuse. Second, a research study explores experiences of shame and guilt for this population. More specifically, the study examines those factors in the therapeutic process which surv

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Calao, Miriam. "Role of IkB kinase (IKK) complex post-translational modifications in NF-kB signaling and therapeutic applications for the treatment of HIV-1 infection." Doctoral thesis, Universite Libre de Bruxelles, 2009. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210318.

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Les facteurs de transcription de la famille Rel/NF-κB régulent l’expression d’un grand nombre de gènes impliqués dans les réponses immunitaires et inflammatoires ainsi que dans la régulation de la prolifération et de la survie cellulaire. Le caractère transitoire de l’activation de NF-κB est donc crucial pour poterger les cellules de l’autoxicité due à une trop forte expression des gènes cibles de ce facteur de transcription. Dans le cadre de notre thèse de doctorat, nous avons étudié les mécanismes moléculaires régulant la cinétique d’activation de NF-κB, en accordant une attention toute part

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Liman, Suryamin, and 陳明正. "Ketamine on chronic post-ischemia pain (CPIP) model of complex regional pain syndrome (CRPS) type I in Sprague-Dawley (SD) rats." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B45989448.

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Haraszti, Reka A. "Engineered Exosomes for Delivery of Therapeutic siRNAs to Neurons." eScholarship@UMMS, 2018. https://escholarship.umassmed.edu/gsbs_diss/971.

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Extracellular vesicles (EVs), exosomes and microvesicles, transfer endogenous RNAs between neurons over short and long distances. We have explored EVs for siRNA delivery to brain. (1) We optimized siRNA chemical modifications and siRNA conjugation to lipids for EV-mediated delivery. (2) We developed a GMP-compatible, scalable method to manufacture active EVs in bulk. (3) We characterized lipid and protein content of EVs in detail. (4) We established how protein and lipid composition relates to siRNA delivering activity of EVs, and we reverse engineered natural exosomes (small EVs) into artific

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Dharmalingam, Backialakshmi [Verfasser]. "Immune mediated disturbances of bone, connective tissue and vascular metabolism in Complex Regional Pain Syndrome (CRPS) : a new pathogenic mechanism of therapeutic relevance / Backialakshmi Dharmalingam." Gießen : Universitätsbibliothek, 2015. http://d-nb.info/1076980287/34.

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RIZZA, SALVATORE. "Nitrosative stress due to GSNOR deficiency induces agingrelated mitochondrial impairment and enhances vulnerability to mitochondrial complex II-targeting drugs: a potential therapeutic approach for HCC." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2012. http://hdl.handle.net/2108/202225.

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The denitrosylating enzyme GSNOR profoundly impact s on cellular signal transduction by controlling cellular concentrations of protein-SNOs. Excessive S-nitrosylation is a well-documented phenomenon known as nitrosative stress, which increases during age. In this phD thesis we provide evidence that GSNOR physiologically may undergo epigenetic silencing during aging probably due to DNA methylation of its promoter, carried out by TET proteins. It is plausible to speculate, therefore, that nitrosative stress occurring upon GSNOR deficiency, could compromise mitochondrial function, resembling, in

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Styslinger, Thomas James. "The Development and Application of Novel Methods for the Chemical Glycosylation of Therapeutic Proteins & A Chemical Approach to Understanding Glycosyltransferases and Their Application in the Synthesis of Complex Carbohydrates." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1313009079.

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Aguilera, Katrina. "A grounded theory study of time-limited therapy for complex trauma : how NHS psychologists manage the challenge of working with developmentally traumatised clients within a time-limited therapeutic frame." Thesis, London Metropolitan University, 2018. http://repository.londonmet.ac.uk/2623/.

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Psychological research in the field of childhood trauma indicates that the earlier the age of onset and the more severe the traumatisation in terms of intensity, duration and repetition, the more extensively impaired individuals become. In such cases long-term, phase-oriented treatment is recommended. Over the last decade, the NHS has undergone significant changes in the delivery of psychological therapies. There has been a substantial rise in the use of evidence-based practice and time-limited psychological treatment has become a focal point in the delivery of clinical interventions within co

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Milone, Lisa J. "Therapist Attachment and Meaning-Making in Adolescent Residential Treatment." Antioch University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=antioch1576277906453219.

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Dzama, Margarita [Verfasser]. "Combined targeting of the Menin-MLL chromatin regulatory complex and the FLT3 tyrosine kinase as a novel therapeutic approach against NPM1mut and MLL-r leukemia with concurrent FLT3 mutation / Margarita Dzama." Mainz : Universitätsbibliothek der Johannes Gutenberg-Universität Mainz, 2021. http://d-nb.info/1234148587/34.

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Mina, Kym Deanne. "Measurement of fish consumption in population-based studies of cancer." University of Western Australia. School of Population Health, 2007. http://theses.library.uwa.edu.au/adt-WU2007.0093.

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[Truncated abstract] The role of fish consumption and omega-3 polyunsaturated fatty acids (PUFAs) in the prevention of disease has been the subject of much investigation in recent years. A clue that these factors might be of importance was the observation that populations consuming high levels of marine omega-3 PUFAs had lower rates of morbidity and mortality from cardiovascular disease. From there, research in this area has expanded to include a range of chronic diseases and their prevention. An area of particular interest is the role of fish consumption in the prevention of various cancers.

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Moreira, Samuel Thadeu GÃes. "AnÃlise da eficiÃncia tÃcnica da estratÃgia competitiva de uma clÃnica de medicina do trabalho no Estado do CearÃ." Universidade Federal do CearÃ, 2014. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=12923.

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nÃo hÃ<br>A SaÃde Ã um importante fator para o desenvolvimento e bem-estar de uma sociedade. Na construÃÃo de um modelo de saÃde ideal, deve-se investir muito em medidas que visem Ã prÃtica da Medicina Preventiva. A Medicina Ocupacional Ã um dos setores da Medicina Preventiva que mais vem apresentando crescimento, com o advento de leis trabalhistas mais rigorosas que buscam, acima de tudo, prezar pela saÃde e seguranÃa dos trabalhadores. Com esse crescimento, a competitividade no mercado de instituiÃÃes privadas de SeguranÃa e Medicina do Trabalho passou a exigir mais controle e eficiÃncia den

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Leman, Géraldine. "Régulation de la fonction mitochondriale par le rapport NADH/NAD+ : le rôle clef du complexe I." Thesis, Angers, 2014. http://www.theses.fr/2014ANGE0016/document.

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Le NAD+ apparaît comme un régulateur majeur du fonctionnement mitochondrial. En effet, ce cofacteur régule non seulement l’activité de nombreuses enzymes impliqués dans le métabolisme énergétique (enzymes de la β-oxydation des acides gras, du cycle de Krebs) mais joue également un rôle dans la production d’espèces réactives de l’oxygène (ROS). Le NAD+ est aussi le cofacteur des sirtuines, des enzymes déacétylases régulatrices notamment du métabolisme mitochondrial. De plus, la mitochondrie est l’organite au sein duquel la concentration en NAD+ est la plus élevée (jusqu’à 70% du NAD cellulaire)

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Soares, Lúcia Pinho. "A eficácia terapêutica da fisioterapia no linfedema pós cirurgia de cancro da mama: uma revisão bibliográfica." Bachelor's thesis, [s.n.], 2016. http://hdl.handle.net/10284/5693.

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Projeto de Graduação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Licenciada em Fisioterapia<br>Introdução: Alguma controvérsia existe no que respeita à validação das diversas técnicas utilizadas no tratamento de doentes com cancro da mama submetidos a cirurgia. Objetivo: Analisar o efeito das diversas técnicas terapêuticas utilizadas em Fisioterapia no Linfedema do membro superior, decorrente da cirurgia mamária por carcinoma. Metodologia: A pesquisa foi realizada nas bases de dados Pubmed e PEDro, datadas entre 2006 e 2016, sendo os artigos cl

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Saling, Salomé. "Activité physique adaptée, éducation thérapeutique du patient et approche socio-écologique de la santé du patient insuffisant rénal chronique : impacts systémiques sur les dynamiques identitaires des personnes atteintes de la maladie." Thesis, Strasbourg, 2019. http://www.theses.fr/2019STRAG011/document.

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L’insuffisance rénale chronique (IRC) est une pathologie entraînant des complications sur la santé. Au stade terminal, le patient doit avoir recours à un traitement curatif. La qualité de vie s’en retrouve altérée et l’identité de la personne en est malmenée. L’activité physique adaptée (APA), ancrée dans un programme d’éducation thérapeutique du patient, va octroyer de nouveaux rôles. Nous nous intéressons à 10 patients IRC qui bénéficient d’un programme d’APA durant 6 mois. La pensée systémique de la santé nous permet d’évaluer les effets de cette prise en charge globale sur les dynamiques i

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Bretones, Santamarina Jorge. "Integrated multiomic analysis, synthetic lethality inference and network pharmacology to identify SWI/SNF subunit-specific pathway alterations and targetable vulnerabilities." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASL049.

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De nos jours, la communauté scientifique s'accorde sur la nécessité de diagnostics et de thérapies personnalisés pour les patients atteints de cancer, conçus par des études translationnelles combinant approches expérimentales et statistiques. Les défis actuels incluent la validation de modèles expérimentaux précliniques et leur profilage multi-omiques, ainsi que la conception de méthodes bioinformatiques et mathématiques dédiées pour identifier les combinaisons de médicaments optimales pour chaque patient.Cette thèse a visé à concevoir de telles approches statistiques pour analyser différents

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Fu, Sue-Chin, and 傅書琴. "Preventive and therapeutic effects of vanillin for inflammatory bowel disease in mice." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/18330515027191244429.

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碩士<br>中國醫藥大學<br>醫學研究所碩士班<br>94<br>The inflammatory bowel diseases (IBD) is recognized as an important gastrointestinal diseases in children and adults. Pathogenesis of IBD is ambiguous. The expressions of proinflammatory cytokine genes, including interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, IL-4 and interferon (IFN)-γ, might be involved in the pathogenesis of IBD. Since the expression of cytokine gene is mainly regulated by the transcription factor nuclear factor-κB (NF-κB), the NF-κB might be the target for the development of anti-IBD drugs. Vanillin is a widely used flavor compo

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Kant, Rajni, and 康竣磊. "Identification of small molecules/natural compounds for therapeutic/preventive uses in liver cancer." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/2wnyeg.

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