Academic literature on the topic 'Therapeutic equivalency in drugs'

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Journal articles on the topic "Therapeutic equivalency in drugs"

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Wilner, Andrew N. "Therapeutic equivalency of generic antiepileptic drugs: results of a survey." Epilepsy & Behavior 5, no. 6 (2004): 995–98. http://dx.doi.org/10.1016/j.yebeh.2004.05.011.

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Rokita, Konrad, Grzegorz Cessak, Marta Dąbrowska, and Ewa Bałkowiec-Iskra. "Therapeutic equivalence of psychotropic drugs." Pharmacological Reports 67 (September 2015): 37. http://dx.doi.org/10.1016/j.pharep.2015.06.112.

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Schellekens, Huub, Ety Klinger, Stefan Mühlebach, Jean-Francois Brin, Gert Storm, and Daan J. A. Crommelin. "The therapeutic equivalence of complex drugs." Regulatory Toxicology and Pharmacology 59, no. 1 (2011): 176–83. http://dx.doi.org/10.1016/j.yrtph.2010.09.021.

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Verbeeck, R. K. "BIOEQUIVALENCE, THERAPEUTIC EQUIVALENCE AND GENERIC DRUGS." Acta Clinica Belgica 64, no. 5 (2009): 379–83. http://dx.doi.org/10.1179/acb.2009.063.

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Sakuma, A. "Evaluation of Clinical Equivalence of Therapeutic Drugs." Japanese Journal of Biometrics 15, no. 2 (1994): 73–74. http://dx.doi.org/10.5691/jjb.15.73.

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Rokita, K., E. Balkowiec-Iskra, and G. Cessak. "Bioequivalence and Therapeutic Equivalence of Psychotropic Drugs." European Psychiatry 30 (March 2015): 1594. http://dx.doi.org/10.1016/s0924-9338(15)31231-1.

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Cessak, Grzegorz, Konrad Rokita, and Ewa Bałkowiec-Iskra. "Bioequivalence and therapeutic equivalence of psychotropic drugs." Postępy Psychiatrii i Neurologii 24, no. 1 (2015): 8–17. http://dx.doi.org/10.1016/j.pin.2015.01.001.

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Santosh Kumar, Rada, and G. V. R. L. Soujanya. "Therapeutic Equivalence: A Connecting Link Between Test Drug and Reference Drug." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 829–31. http://dx.doi.org/10.22270/jddt.v9i4-s.3395.

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The concept of therapeutic equivalence is becoming increasingly important in today’s cost – conscious environment. Though an effective therapy already exists, but clinically equivalent therapy also becoming important. An improved toxicity profile better effects on symptoms and ease of administration may be important considerations. In these positive controls substantial effect is required to define equivalence. The goal is to prove that the new treatment is not inferior to standard, since providing that two treatments are equal is not possible. The superiority trials demonstrate the better eff
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Remport, Ádám, Dávid Dankó, Zsuzsa Gerlei, Krisztina Czebe, and István Kiss. "Special considerations in generic substitution of immunosuppressive drugs in transplantation." Orvosi Hetilap 153, no. 34 (2012): 1341–49. http://dx.doi.org/10.1556/oh.2012.29429.

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Long-term success in solid organ transplantation strongly depends on the optimal use of maintenance immunosuppressive treatment. Cyclosporin and tacrolimus are the most frequently administered immunosuppressants and they are designed to narrow therapeutic index drugs. The substitution of the branded formulation by their generic counterparts may lead to economic benefit only if equivalent clinical outcomes can be achieved. There is no published evidence to date on the guarantee of their long-term therapeutic equivalence and cases of therapeutic failures have been reported due to inadvertent dru
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Sankar, Raman, and Tracy A. Glauser. "Understanding Therapeutic Equivalence in Epilepsy." CNS Spectrums 15, no. 2 (2010): 112–23. http://dx.doi.org/10.1017/s1092852900027358.

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ABSTRACTThe issues surrounding generic drug substitution in patients with epilepsy are complex.The substitution of one formulation of an antiepileptic drug (AED) for another is controversial. Well-reasoned and defensible cases can be made both for and against such substitution. Although regulatory agencies require that generic and proprietary drugs have similar pharmacokinetic bioequivalence data, their therapeutic efficacy may not necessarily be identical. The paroxysmal nature of epilepsy, the narrow therapeutic index of some AEDs, the need to. individualize therapy to achieve seizure contro
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Dissertations / Theses on the topic "Therapeutic equivalency in drugs"

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Parfitt, Natalie Rae. "Investigations of the assessment of bioequivalence of topical clotrimazole products using a dermatopharmacokinetic approach." Thesis, Rhodes University, 2010. http://hdl.handle.net/10962/d1007659.

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The specialised nature of the stratum corneum makes it an efficient barrier to foreign substances, including drug molecules. Therefore, cutaneous drug absorption is a slow and complex process of which stratum corneum penetration is the rate limiting step. The rate and extent of stratum corneum penetration by a drug compound depends greatly on the presence of penetration enhancing/retarding excipients and therefore the clinical outcomes of a product rely greatly on the components and quality of the formulation. Hence, establishing bioequivalence between topical products is crucial to ensure tha
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Petrellis, Maria Carla. "Estudo de bioequivalencia de duas formulações de comprimidos de pantoprazol em voluntarios sadios de ambos os sexos." [s.n.], 2004. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309504.

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Orientador: Gilberto de Nucci<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-04T02:37:59Z (GMT). No. of bitstreams: 1 Petrellis_MariaCarla_M.pdf: 11345531 bytes, checksum: ffdc235c08929ac07ceecf4c90887171 (MD5) Previous issue date: 2004<br>Resumo: A tese de doutoramento intitulada "A questão da passividade na melancolia: paradigma de Hamlef' trata de alguns o questionamentos clínicos sobre a ação da passividade e, conseqüente impacto sobre a relação analítica, num caso de melancolia. Sua descrição teórica é
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Mendes, Gustavo Duarte. "Planejamento e avaliação de estudos de biodisponibilidade relativa para medicamentos genericos." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309503.

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Orientador: Gilberto De Nucci<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-08T21:47:39Z (GMT). No. of bitstreams: 1 Mendes_GustavoDuarte_D.pdf: 4560955 bytes, checksum: 46a77f9c7609d08ca99e21f6b7003536 (MD5) Previous issue date: 2007<br>Resumo: Os estudos de biodisponibilidade/bioequivalência foram iniciados no Brasil em 1989 e o processo de regulamentação do setor foi iniciado em 1999 pela promulgação da lei de genéricos. A regulamentação do setor tem propiciado grande aumento na qualidade de fabricação dos me
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Muñoz, Gutiérrez Joel Alejandro. "Bioequivalencia promedio escalada." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/456804.

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La agencia europea del medicamento, EMA, y la estadounidense FDA, propusieron límites de bioequivalencia (BE) “escalada” para facilitar la declaración BE de genéricos de drogas de alta variabilidad (HVD). La determinación de la BE para una (HVD) fue una cuestión ampliamente debatida en los años finales del siglo XX y la primera década del siglo XXI (p.e. Shah et al. 1996, Tothfalusi et al, 2001, Tothfalusi et al. 2003). A principios de la presente década, tanto la EMA como la FDA presentaron regulaciones, que se basan en criterios escalados, sobre HVD
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Garcia, Monclús Silvia. "EPHA2 com a diana terapèutica pel sarcoma d'Ewing." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/456480.

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El sarcoma d’Ewing (SE) és el segon tumor ossi més freqüent en nens i adults joves, i presenta una incidència d’un màxim de 5 casos per milió en adolescents. Una de les característiques principals del SE és la seva gran capacitat metastàtica, aproximadament un 30 % dels casos en el moment del diagnòstic. Aquest fet és especialment greu ja que fa caure la taxa de supervivència fins a un 20 %. A nivell molecular, el SE es caracteritza per la presència d’una translocació cromosòmica que, en la majoria dels casos, dóna com a resultat la proteïna de fusió EWS/FLI1. La proteïna de fusió actua com
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Khin, Myo Oo Korbtham Sathirakul. "Bioequivalence study of pioglitazone tablets in Thai healthy volunteers /." Abstract, 2007. http://mulinet3.li.mahidol.ac.th/thesis/2550/cd401/4837398.pdf.

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Au, Wai Ling. "Investigations of the bioavailability/bioequivalence of topical corticosteroid formulations containing clobetasol propionate using the human skin blanching assay, tape stripping and microdialysis." Thesis, Rhodes University, 2010. http://hdl.handle.net/10962/d1003221.

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Currently, clinical trials in patients are required by most regulatory authorities for the assessment of bioequivalence of topical products where the drug is not intended for systemic absorption. Hence there is a dire need for suitable methods for the assessment of bioavailability and bioequivalence of such products since clinical safety and efficacy studies are expensive, time-consuming and require very large numbers of patients. Except for topical corticosteroid products where the human skin blanching assay/vasoconstrictor assay has been approved by the US FDA for bioequivalence assessment o
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Modolo, Fabiana Duarte Mendes e. 1973. "Estudo de biodisponibilidade comparativa de uma formulação teste (Lipless [ciprofibrato] - comprimido - 100 mg; Biolab Sanus Farmacêutica Ltda.) versus uma formulação referência (Oroxadin [ciprofibrato] comprimido - 100 mg; Sanofi-Aventis) em voluntários sadios de ambos os sexos." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309463.

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Orientador: Gilberto de Nucci<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-21T11:09:12Z (GMT). No. of bitstreams: 1 Modolo_FabianaDuarteMendese_D.pdf: 4445677 bytes, checksum: 5d3f6fadf0884c24742741c6059792dc (MD5) Previous issue date: 2012<br>Resumo: Método rápido, sensível e específico foi desenvolvido para quantificar ciprofibrato no plasma humano, utilizando bezafibrato como padrão interno (SI). O analito e o padrão interno foram extraídos do plasma, por extração líquido-líquido, usando um solvente orgânico
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Pereira, Heliana Martins. "Etapa bioanalítica de estudos de BD/BE: um novo olhar da garantia da qualidade em busca da qualidade total." reponame:Repositório Institucional da FIOCRUZ, 2014. https://www.arca.fiocruz.br/handle/icict/9944.

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Submitted by Alexandre Sousa (alexandre.sousa@incqs.fiocruz.br) on 2015-04-10T11:28:22Z No. of bitstreams: 1 Tese_Heliana.pdf: 5204865 bytes, checksum: 96e0c7d76a906d0b86274058a747043a (MD5)<br>Approved for entry into archive by Alexandre Sousa (alexandre.sousa@incqs.fiocruz.br) on 2015-04-10T11:29:14Z (GMT) No. of bitstreams: 1 Tese_Heliana.pdf: 5204865 bytes, checksum: 96e0c7d76a906d0b86274058a747043a (MD5)<br>Approved for entry into archive by Alexandre Sousa (alexandre.sousa@incqs.fiocruz.br) on 2015-04-10T11:30:15Z (GMT) No. of bitstreams: 1 Tese_Heliana.pdf: 5204865 bytes, checksum:
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Tettey-Amlalo, Ralph Nii Okai. "Application of dermal microdialysis and tape stripping methods to determine the bioavailability and/or bioequivalence of topical ketoprofen formulations." Thesis, Rhodes University, 2008. http://hdl.handle.net/10962/d1003274.

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The widespread acceptance of topical formulations intended for local and/or regional activity has prompted renewed interest in developing a model to determine the bioavailability of drugs in order to establish bioequivalence as a means of evaluating formulation performance of multisource products and also for use during formulation development. Current in vivo techniques such as blister suction and skin biopsy amongst others used to determine the bioavailability and/or bioequivalence of topical formulations are either too invasive to generate appropriate concentration-time profiles or require
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Books on the topic "Therapeutic equivalency in drugs"

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The essential guide to generic drugs. Harper & Row, 1986.

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Virginia. General Assembly. Joint Commission on Health Care. Therapeutic interchange of chemically dissimilar drugs study pursuant to HJR 734: Report of the Joint Commission on Health Care to the Governor and the General Assembly of Virginia. Commonwealth of Virginia, 2000.

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Stauffer, Samuel. Drug comparison handbook. Skidmore-Roth Pub., 1993.

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Shargel, Leon, and Isadore Kanfer. Generic drug product development: Specialty dosage forms. Informa Healthcare USA, 2010.

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Yong, Chʻŏl-sun. Pi kyŏngguyong cheje ŭi saengmurhakchŏk tongdŭngsŏng hwakpo pangan e taehan yŏnʼgu =: Investigation for establishment of guidelines to assure bioequivalence of nonoral dosage forms. Sikpʻum Ŭiyakpʻum Anjŏnchʻŏng, 2007.

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FIP, Bio-International '96 (1996 Tokyo Japan). Bioavailability, bioequivalence and pharmacokinetic studies: FIP Bio-International '96 : International Conference of F.I.P. "Bio-International '96", Tokyo, Japan, April 22-24, 1996. Business Center for Academic Societies Japan, 1996.

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Robert, Reilly. Drug comparison handbook. 2nd ed. Skidmore-Roth Pub., 1995.

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Drug comparison handbook. 3rd ed. Skidmore-Roth Pub., 1998.

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Yu, L. X., and Bing V. Li. FDA bioequivalence standards. AAPS Press/Springer, 2014.

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1951-, Jones Byron, ed. Bioequivalence and statistics in clinical pharmacology. Chapman & Hall/CRC, 2006.

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Book chapters on the topic "Therapeutic equivalency in drugs"

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Pennington, C. R. "Drugs and Nutrition." In Therapeutic Nutrition. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4899-7108-1_9.

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Levine, Barry S. "Miscellaneous Therapeutic Drugs." In Principles of Forensic Toxicology. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-42917-1_29.

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Grundy, S. M. "Metabolic Syndrome: Therapeutic Considerations." In Atherosclerosis: Diet and Drugs. Springer Berlin Heidelberg, 2005. http://dx.doi.org/10.1007/3-540-27661-0_3.

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Wiltenburg, Victor Distefano, Dianne da Rocha Prado, and Fúlvio Rieli Mendes. "Therapeutic Use of Hallucinogens." In Drugs and Human Behavior. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-62855-0_35.

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Johnstone, Frank D., and David C. Howe. "Therapeutic Drugs, Recreational Drugs and Lifestyle Factors." In Intrauterine Growth Restriction. Springer London, 2000. http://dx.doi.org/10.1007/978-1-4471-0735-4_4.

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Hoare, Anilei, Philip D. Marsh, and Patricia I. Diaz. "Ecological Therapeutic Opportunities for Oral Diseases." In Bugs as Drugs. ASM Press, 2018. http://dx.doi.org/10.1128/9781555819705.ch10.

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Landry, Brian P., and Jeffrey J. Tabor. "Engineering Diagnostic and Therapeutic Gut Bacteria." In Bugs as Drugs. ASM Press, 2018. http://dx.doi.org/10.1128/9781555819705.ch14.

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Reid, Gregor. "Therapeutic Opportunities in the Vaginal Microbiome." In Bugs as Drugs. ASM Press, 2018. http://dx.doi.org/10.1128/9781555819705.ch6.

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Saxena, Pramod R., David E. Clarke, Anthony P. D. W. Ford, et al. "Therapeutic Possibilities with Serotonergic Drugs." In Pharmacological Sciences: Perspectives for Research and Therapy in the Late 1990s. Birkhäuser Basel, 1995. http://dx.doi.org/10.1007/978-3-0348-7218-8_23.

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Wheless, James W. "Therapeutic Efficacy of Antiepileptic Drugs." In Epilepsy in Children and Adolescents. John Wiley & Sons, Ltd, 2012. http://dx.doi.org/10.1002/9781119998600.ch10.

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Conference papers on the topic "Therapeutic equivalency in drugs"

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Danesh, B. J. Z., A. R. Saniabadi, R. I. Russell, G. D. O. Lowe, and C. D. Forbes. "COMPARISON OF THE EFFECT OF ASPIRIN (ASA) AND CHOLINE MAGNESIUM TRISALICYLATE (CMT) ON PLATELET AGGREGATION IN WHOLE BLOOD EX-VIVO." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644866.

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Suppression of platelet aggregation by ASA limits the therapeutic use of this drug as an analgesic in patients with bleeding tendencies. CMT is a non-acetylated salicylate derivative with analgesic and anti-inflammatory effect similar to that of ASA. We compared platelet aggregation in human whole blood ex-vivo, three hours after ingestion of ASA and. CMT. Using a whole blood platelet counter, platelet aggregation was quantified by measuring the fall in the number of single platelets at peak aggregation in response to collagen (lμg/ml) arachidonic acid (AA, 0.5 mM) as well as spontaneous aggre
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Chen, Kok Hao, and Jong Hyun Choi. "Nanoparticle-Aptamer: An Effective Growth Inhibitor for Human Cancer Cells." In ASME 2009 International Mechanical Engineering Congress and Exposition. ASMEDC, 2009. http://dx.doi.org/10.1115/imece2009-11966.

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Semiconductor nanocrystals have unique optical properties due to quantum confinement effects, and a variety of promising approaches have been devised to interface the nanomaterials with biomolecules for bioimaging and therapeutic applications. Such bio-interface can be facilitated via a DNA template for nanoparticles as oligonucleotides can mediate the aqueous-phase nucleation and capping of semiconductor nanocrystals.[1,2] Here, we report a novel scheme of synthesizing fluorescent nanocrystal quantum dots (NQDs) using DNA aptamers and the use of this biotic/abiotic nanoparticle system for gro
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Martin, Diana I., Elena N. Manaila, Mihaela I. Moisescu, et al. "Radiation Interaction with Therapeutic Drugs and Cell Membranes." In SIXTH INTERNATIONAL CONFERENCE OF THE BALKAN PHYSICAL UNION. AIP, 2007. http://dx.doi.org/10.1063/1.2733557.

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Endres, K., and E. Haen. "Importance of antihypertensive drugs in psychiatry." In XIIIth Symposium of the Task Force Therapeutic Drug Monitoring of the AGNP. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1649529.

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Hart, XM, G. Gründer, and C. Hiemke. "10 How valid are therapeutic reference ranges for psychotropic drugs?" In XIVth Symposium of the Task Force Therapeutic Drug Monitoring of the AGNP. © Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0040-1710118.

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Lipecki, Y., and E. Haen. "TDM of antiepileptic drugs in psychiatric patients." In XIIIth Symposium of the Task Force Therapeutic Drug Monitoring of the AGNP. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1649537.

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Prawiradiredja, Sanhari, Iwan Prasetyo, and R. Jusnita. "Internal and External Rehabilitation Process of East Java Drugs Therapy Houses in Therapeutic Communication for Drugs Addicts." In Proceedings of the 4th International Conference on Indonesian Social and Political Enquiries, ICISPE 2019, 21-22 October 2019, Semarang, Central Java, Indonesia. EAI, 2020. http://dx.doi.org/10.4108/eai.21-10-2019.2294431.

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Limpaiboon, Temduang, and Ruethairat Sriraksa. "Abstract 1004: Histone deacetylase inhibitors: Potential epigenetic therapeutic drugs for cholangiocarcinoma." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-1004.

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Goueli, Said A., and Kevin Hsiao. "Abstract 1162: Monitoring COVID-19 RNA methyltransferases activities for developing therapeutic drugs." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-1162.

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Hadjisavvas, V., K. Ioannides, C. Damianou, Yoichiro Matsumoto, Lawrence A. Crum, and Gail Reinette ter Haar. "Application of MR-guided focused pulsed ultrasound for destroying clots in vitro using thrombolytic drugs." In 10TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND (ISTU 2010). AIP, 2011. http://dx.doi.org/10.1063/1.3607893.

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Reports on the topic "Therapeutic equivalency in drugs"

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Bhushan, Arya, and Anuradha Vummenthala. Promising Investigational Therapeutic Drugs for the Treatment of COVID-19: A Review. Journal of Young Investigators, 2021. http://dx.doi.org/10.22186/jyi.37.1.1-7.

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Bhushan, Arya, and Anuradha Vummenthala. Promising Investigational Therapeutic Drugs for the Treatment of COVID-19: A Review. Journal of Young Investigators, 2021. http://dx.doi.org/10.22186/jyi.39.1.1-7.

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ARIZONA STATE UNIV TEMPE CANCER RESEARCH INST. Discovery and Development of Therapeutic Drugs Against Lethal Human RNA Viruses: A Multidisciplinary Assault. Defense Technical Information Center, 1992. http://dx.doi.org/10.21236/ada251561.

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Pettit, George R. Discovery and Development of Therapeutic Drugs against Lethal Human RNA Viruses: a Multidisciplinary Assault. Defense Technical Information Center, 1991. http://dx.doi.org/10.21236/ada239742.

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Pettit, George R. Discovery and Development of Therapeutic Drugs against Lethal Human RNA- Viruses: A Multidisciplinary Assault. Defense Technical Information Center, 1990. http://dx.doi.org/10.21236/ada219393.

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Roh, Meejeon. Therapeutic Value of PLK1 Knockdown in Combination with Prostate Cancer Drugs in PIM-1 Overexpressing Prostate Cancer Cells. Defense Technical Information Center, 2014. http://dx.doi.org/10.21236/ada613551.

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Roh, Meejeon. Therapeutic Value of PLK1 Knockdown in Combination with Prostate Cancer Drugs in PIM-1 Overexpressing Prostate Cancer Cells. Defense Technical Information Center, 2013. http://dx.doi.org/10.21236/ada582132.

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Yang, Nannan, Qiaoyan Wu, Faren Xu, and Xiaopeng Zhang. Comparisons of therapeutic safety of seven oral antimuscarinic drugs in patients with overactive bladder: A network meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2021. http://dx.doi.org/10.37766/inplasy2021.7.0095.

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Coelho Resende, Noelle, Renata Weber, Jardel Fischer Loeck, et al. Working Paper Series: Therapeutic Communities in Brazil. Edited by Taniele Rui and Fiore Mauricio. Drugs, Security and Democracy Program, Social Science Research Council, 2021. http://dx.doi.org/10.35650/ssrc.2081.d.2021.

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Spread across Brazil and attaining an unparalleled political force, therapeutic communities are as inescapable in the debate on drug policy as they are complex to define. Although they are not a Brazilian creation, they have been operating in that country for decades, and their dissemination intensified in the 1990s. In 2011, they were officially incorporated into Brazil's Psychosocial Care Network (Rede de Atenção Psicossocial, or RAPS). Since then, therapeutic communities have been at the center of public debates about their regulation; about how they should—or even if they should—be a part
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Han, Lizhu, Yunlan Wang, Kunxia Hu, Zhishu Tang, and Xiao Song. The therapeutic efficacy of Huashi Baidu Formula combined with antiviral drugs in the treatment of COVID-19: A protocol for systematic review and meta analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2020. http://dx.doi.org/10.37766/inplasy2020.8.0098.

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