Log in

Relevant bibliographies by topics / Therapeutic equivalency in drugs / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Therapeutic equivalency in drugs.

Dissertations / Theses on the topic 'Therapeutic equivalency in drugs'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Therapeutic equivalency in drugs.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Parfitt, Natalie Rae. "Investigations of the assessment of bioequivalence of topical clotrimazole products using a dermatopharmacokinetic approach." Thesis, Rhodes University, 2010. http://hdl.handle.net/10962/d1007659.

Full text

Abstract:

The specialised nature of the stratum corneum makes it an efficient barrier to foreign substances, including drug molecules. Therefore, cutaneous drug absorption is a slow and complex process of which stratum corneum penetration is the rate limiting step. The rate and extent of stratum corneum penetration by a drug compound depends greatly on the presence of penetration enhancing/retarding excipients and therefore the clinical outcomes of a product rely greatly on the components and quality of the formulation. Hence, establishing bioequivalence between topical products is crucial to ensure tha

APA, Harvard, Vancouver, ISO, and other styles

2

Petrellis, Maria Carla. "Estudo de bioequivalencia de duas formulações de comprimidos de pantoprazol em voluntarios sadios de ambos os sexos." [s.n.], 2004. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309504.

Full text

Abstract:

Orientador: Gilberto de Nucci<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-04T02:37:59Z (GMT). No. of bitstreams: 1 Petrellis_MariaCarla_M.pdf: 11345531 bytes, checksum: ffdc235c08929ac07ceecf4c90887171 (MD5) Previous issue date: 2004<br>Resumo: A tese de doutoramento intitulada "A questão da passividade na melancolia: paradigma de Hamlef' trata de alguns o questionamentos clínicos sobre a ação da passividade e, conseqüente impacto sobre a relação analítica, num caso de melancolia. Sua descrição teórica é

APA, Harvard, Vancouver, ISO, and other styles

3

Mendes, Gustavo Duarte. "Planejamento e avaliação de estudos de biodisponibilidade relativa para medicamentos genericos." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309503.

Full text

Abstract:

Orientador: Gilberto De Nucci<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-08T21:47:39Z (GMT). No. of bitstreams: 1 Mendes_GustavoDuarte_D.pdf: 4560955 bytes, checksum: 46a77f9c7609d08ca99e21f6b7003536 (MD5) Previous issue date: 2007<br>Resumo: Os estudos de biodisponibilidade/bioequivalência foram iniciados no Brasil em 1989 e o processo de regulamentação do setor foi iniciado em 1999 pela promulgação da lei de genéricos. A regulamentação do setor tem propiciado grande aumento na qualidade de fabricação dos me

APA, Harvard, Vancouver, ISO, and other styles

4

Muñoz, Gutiérrez Joel Alejandro. "Bioequivalencia promedio escalada." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/456804.

Full text

Abstract:

La agencia europea del medicamento, EMA, y la estadounidense FDA, propusieron límites de bioequivalencia (BE) “escalada” para facilitar la declaración BE de genéricos de drogas de alta variabilidad (HVD). La determinación de la BE para una (HVD) fue una cuestión ampliamente debatida en los años finales del siglo XX y la primera década del siglo XXI (p.e. Shah et al. 1996, Tothfalusi et al, 2001, Tothfalusi et al. 2003). A principios de la presente década, tanto la EMA como la FDA presentaron regulaciones, que se basan en criterios escalados, sobre HVD

APA, Harvard, Vancouver, ISO, and other styles

5

Garcia, Monclús Silvia. "EPHA2 com a diana terapèutica pel sarcoma d'Ewing." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/456480.

Full text

Abstract:

El sarcoma d’Ewing (SE) és el segon tumor ossi més freqüent en nens i adults joves, i presenta una incidència d’un màxim de 5 casos per milió en adolescents. Una de les característiques principals del SE és la seva gran capacitat metastàtica, aproximadament un 30 % dels casos en el moment del diagnòstic. Aquest fet és especialment greu ja que fa caure la taxa de supervivència fins a un 20 %. A nivell molecular, el SE es caracteritza per la presència d’una translocació cromosòmica que, en la majoria dels casos, dóna com a resultat la proteïna de fusió EWS/FLI1. La proteïna de fusió actua com

APA, Harvard, Vancouver, ISO, and other styles

6

Khin, Myo Oo Korbtham Sathirakul. "Bioequivalence study of pioglitazone tablets in Thai healthy volunteers /." Abstract, 2007. http://mulinet3.li.mahidol.ac.th/thesis/2550/cd401/4837398.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Au, Wai Ling. "Investigations of the bioavailability/bioequivalence of topical corticosteroid formulations containing clobetasol propionate using the human skin blanching assay, tape stripping and microdialysis." Thesis, Rhodes University, 2010. http://hdl.handle.net/10962/d1003221.

Full text

Abstract:

Currently, clinical trials in patients are required by most regulatory authorities for the assessment of bioequivalence of topical products where the drug is not intended for systemic absorption. Hence there is a dire need for suitable methods for the assessment of bioavailability and bioequivalence of such products since clinical safety and efficacy studies are expensive, time-consuming and require very large numbers of patients. Except for topical corticosteroid products where the human skin blanching assay/vasoconstrictor assay has been approved by the US FDA for bioequivalence assessment o

APA, Harvard, Vancouver, ISO, and other styles

8

Modolo, Fabiana Duarte Mendes e. 1973. "Estudo de biodisponibilidade comparativa de uma formulação teste (Lipless [ciprofibrato] - comprimido - 100 mg; Biolab Sanus Farmacêutica Ltda.) versus uma formulação referência (Oroxadin [ciprofibrato] comprimido - 100 mg; Sanofi-Aventis) em voluntários sadios de ambos os sexos." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309463.

Full text

Abstract:

Orientador: Gilberto de Nucci<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-21T11:09:12Z (GMT). No. of bitstreams: 1 Modolo_FabianaDuarteMendese_D.pdf: 4445677 bytes, checksum: 5d3f6fadf0884c24742741c6059792dc (MD5) Previous issue date: 2012<br>Resumo: Método rápido, sensível e específico foi desenvolvido para quantificar ciprofibrato no plasma humano, utilizando bezafibrato como padrão interno (SI). O analito e o padrão interno foram extraídos do plasma, por extração líquido-líquido, usando um solvente orgânico

APA, Harvard, Vancouver, ISO, and other styles

9

Pereira, Heliana Martins. "Etapa bioanalítica de estudos de BD/BE: um novo olhar da garantia da qualidade em busca da qualidade total." reponame:Repositório Institucional da FIOCRUZ, 2014. https://www.arca.fiocruz.br/handle/icict/9944.

Full text

Abstract:

Submitted by Alexandre Sousa (alexandre.sousa@incqs.fiocruz.br) on 2015-04-10T11:28:22Z No. of bitstreams: 1 Tese_Heliana.pdf: 5204865 bytes, checksum: 96e0c7d76a906d0b86274058a747043a (MD5)<br>Approved for entry into archive by Alexandre Sousa (alexandre.sousa@incqs.fiocruz.br) on 2015-04-10T11:29:14Z (GMT) No. of bitstreams: 1 Tese_Heliana.pdf: 5204865 bytes, checksum: 96e0c7d76a906d0b86274058a747043a (MD5)<br>Approved for entry into archive by Alexandre Sousa (alexandre.sousa@incqs.fiocruz.br) on 2015-04-10T11:30:15Z (GMT) No. of bitstreams: 1 Tese_Heliana.pdf: 5204865 bytes, checksum:

APA, Harvard, Vancouver, ISO, and other styles

10

Tettey-Amlalo, Ralph Nii Okai. "Application of dermal microdialysis and tape stripping methods to determine the bioavailability and/or bioequivalence of topical ketoprofen formulations." Thesis, Rhodes University, 2008. http://hdl.handle.net/10962/d1003274.

Full text

Abstract:

The widespread acceptance of topical formulations intended for local and/or regional activity has prompted renewed interest in developing a model to determine the bioavailability of drugs in order to establish bioequivalence as a means of evaluating formulation performance of multisource products and also for use during formulation development. Current in vivo techniques such as blister suction and skin biopsy amongst others used to determine the bioavailability and/or bioequivalence of topical formulations are either too invasive to generate appropriate concentration-time profiles or require

APA, Harvard, Vancouver, ISO, and other styles

11

Romano, Patrícia. "Avaliação de risco informatizado e prevenção primária na assistência à saúde das mulheres da cidade de São Paulo." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-31052007-163435/.

Full text

Abstract:

Introdução: O Programa Global de Avaliação de Risco Informatizado - PAISM, através de um questionário com 91 perguntas, permite prever o risco de 9 grupos importantes de doenças, que afetam as mulheres. O Programa examinou 15.538 mulheres determinando o risco para: câncer de mama, endométrio, colo de útero, ovário e pulmão; osteoporose; endometriose; DST/AIDS e dislipidemias e foram classificadas em baixo, médio e alto risco para estas doenças. Baseado no risco de avaliação, o programa ofereceu para as mulheres conselho individualizado com relação a hábitos e comportamentos. Objetivos: Avaliar

APA, Harvard, Vancouver, ISO, and other styles

12

Walker, Teneille. "Therapeutic Drugs in Cancer." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1722.

Full text

Abstract:

The first study examined the interaction between low doses of the multi-kinase inhibitor sorafenib and the histone deacetylase inhibitor vorinostat in colon cancer cells. Sorafenib and vorinostat synergized to kill HCT116 and SW480 cells. In SW480 cells, sorafenib+vorinostat toxicity correlated with CD95 activation and CD95-stimulated autophagy. Drug lethality in SW480 cells was blocked by knock down of CD95. In SW620 cells that are patient matched to SW480 cells, sorafenib+vorinostat toxicity was significantly reduced that correlated with a lack of CD95 activation and lower expression of cer

APA, Harvard, Vancouver, ISO, and other styles

13

Martin, Aditi Pandya. "Therapeutic drugs in cancer and resistance." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1717.

Full text

Abstract:

We investigated the mechanism of toxicity and resistance development of small molecule tyrosine kinase inhibitor lapatinib in HCT 116 colon cancer cells. Lapatinib mediated cell death in HCT 116 cells was caspase independent and involved cytosolic release of apoptosis inducing factor. Treatment of HCT 116 cells with 10µM Lapatinib lead to the outgrowth of lapatinib resistant HCT 116 cells. Our studies show that alterations in the expression and activation of Bcl-2 family proteins allow lapatinib resistant HCT 116 cells to resist cytotoxic effects of lapatinib as well as of other commonly used

APA, Harvard, Vancouver, ISO, and other styles

14

Rocha, Marina Becker Sales. "InfluÃncia da AlimentaÃÃo na Biodisponibilidade da Venlafaxina Administrada em CÃpsulas de LiberaÃÃo Prolongada." Universidade Federal do CearÃ, 2012. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=9764.

Full text

Abstract:

Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>O sucesso do tratamento terapÃutico depende da biodisponibilidade do fÃrmaco, que pode ser afetada pela presenÃa de alimentos. Este estudo teve como objetivo avaliar a influÃncia da alimentaÃÃo na biodisponibilidade de duas formulaÃÃes de venlafaxina, administrada em cÃpsulas de liberaÃÃo prolongada em voluntÃrios sadios. Tratou-se de um estudo clÃnico, aberto, randomizado, cruzado, quatro perÃodos, duas sequÃncias, nos quais voluntÃrios sadios de ambos os sexos receberam 01 cÃpsula de venlafaxina 75mg de liberaÃÃo prolongada da

APA, Harvard, Vancouver, ISO, and other styles

15

Lima, Marinus de Moraes. "ImportÃncia ClÃnica de um Estudo de BioequivalÃncia entre duas FormulaÃÃes de Diclofenaco SÃdico de LiberaÃÃo Prolongada." Universidade Federal do CearÃ, 2013. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=11370.

Full text

Abstract:

CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>O diclofenaco sÃdico Ã um fÃrmaco anti-inflamatÃrio nÃo esteroidal, que exerce seus efeitos por meio da inibiÃÃo da cicloxigenase e modulaÃÃo do Ãcido araquidÃnico; apresenta propriedades analgÃsicas, sendo utilizado para tratamento sintomÃtico de dores, principalmente relacionadas Ã inflamaÃÃo. Ã um fÃrmaco de amplo uso e de fÃcil acesso para o usuÃrio. Um estudo de bioequivalÃncia refere-se Ã comparaÃÃo estatÃstica das principais medidas farmacocinÃticas observadas no experimento, relativas aos produtos a serem testados. Este est

APA, Harvard, Vancouver, ISO, and other styles

16

Fathalla, Salem Mehdi. "Cardiotoxic effects of antipsychotic drugs in therapeutic doses and in overdose." Thesis, University of Newcastle upon Tyne, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.547996.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Oliveira, Sandro Evanir de. "Estudo de bioequivalencia entre duas formulações de oxcarbazepina de 600mg em voluntarios sadios de ambos os sexos." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309508.

Full text

Abstract:

Orientador: Gilberto de Nucci<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-07T11:23:53Z (GMT). No. of bitstreams: 1 Oliveira_SandroEvanirde_M.pdf: 4367932 bytes, checksum: 012ece8285397b7b316af94bf4aea91f (MD5) Previous issue date: 2006<br>Resumo: O presente trabalho tem por objetivo comparar a biodisponibilidade de duas formulações de oxcarbazepina em comprimidos de 600mg, produzidas pelo Laboratório Cristália Produtos Químicos Farmacêuticos Ltda, formulação teste, com a formulação de referência Trileptal

APA, Harvard, Vancouver, ISO, and other styles

18

Moreira, Roberto Fernandes 1979. "Determinação do perfil farmacocinético de medicamentos contendo fármacos de ação central." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311494.

Full text

Abstract:

Orientador: Ney Carter do Carmo Borges<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-26T15:34:25Z (GMT). No. of bitstreams: 1 Moreira_RobertoFernandes_D.pdf: 2940817 bytes, checksum: 525d43271d9ecc3f57856c7a4f024a5d (MD5) Previous issue date: 2014<br>Resumo: Na última década, a evolução dos aspectos técnicos da regulamentação brasileira na área de medicamentos, tendo como base princípios científicos, é inquestionável. A implantação das legislações contribuiu para o aprimoramento da fabricação e garantia de qualid

APA, Harvard, Vancouver, ISO, and other styles

19

Ikhmais, Balqis. "The role of NQO2 in tumour growth and response to therapeutic drugs." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-nqo2-in-tumour-growth-and-response-to-therapeutic-drugs(01ea58b0-c375-43c2-8074-3e0a7034bb21).html.

Full text

Abstract:

NRH quinone oxidoreductase 2 (NQO2) is regarded as a mammalian Phase I detoxifying enzyme responsible for reducing quinones to hydroquinones. NQO2 is highly expressed in different types of cancer such as breast and prostate cancer suggesting its participatory role in the progression of these diseases. A potential reason for this is that NQO2 has the ability to modulate the stability of cyclin D1 and activity of NF-ÃÂoB and it has been shown that inhibition of NQO2, either genetically or pharmacologically, can alter the pattern of proliferation of cancer cells. However, the biological roles

APA, Harvard, Vancouver, ISO, and other styles

20

Hyatt, Alexander James Thompson. "Fibrin gel as a delivery system for drugs, therapeutic proteins, and cells." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609541.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Lee, Todd Allen. "Comparison of the cost-effectiveness of triamicinolone acetonide (azmacort HFA) and fluticasone propionate (flovent) in adult asthmatics in randomized controlled equivalence trial /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/7956.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Lyu, Quanxia. "Therapeutic potential of nucleic acid aptamers against sclerostin in the treatment of osteoporosis." HKBU Institutional Repository, 2017. https://repository.hkbu.edu.hk/etd_oa/431.

Full text

Abstract:

Osteoporosis is a skeletal disease characterized with poor bone quality and low bone mineral density. The pathogenesis of osteoporosis is the imbalance of bone resorption and bone formation. Two strategies can be employed to cure osteoporosis. One is to inhibit bone resorption and the other is to stimulate bone formation. Currently, therapeutic drugs approved by FDA are mainly antiresorptive agents. Till now, there is only one bone anabolic agent approved. Obviously, more efforts should be poured into the development of bone anabolic agents. Sclerostin is a key negative regulator of osteoblast

APA, Harvard, Vancouver, ISO, and other styles

23

Sanders, Gillian. "Therapeutic interventions in the management of hypertension : clinical studies in individuals and the community." Thesis, University of Newcastle Upon Tyne, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.329166.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Gerrard, Stephen Edmund. "A novel infant therapeutic delivery system for drugs, nutrients and anti-viral agents." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648462.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Millette, Andrew. "The Impact of Drug Development News on Pharmaceutical Stock Returns: An Analysis by Therapeutic Class." Thesis, Boston College, 2015. http://hdl.handle.net/2345/bc-ir:104305.

Full text

Abstract:

Thesis advisor: Tracy Regan<br>This study analyzes the response of pharmaceutical firms’ stock prices to the release of information regarding successful Phase III clinical studies and final FDA marketing approval. I employ an event study methodology to show that positive abnormal returns occur at these drug development stages, and that larger abnormal returns occur over a three-day window surrounding a sample of successful Phase III trial announcements in comparison to a sample of FDA approval announcements. To my knowledge, all previous literature of this kind has compared a random sample of

APA, Harvard, Vancouver, ISO, and other styles

26

Archibald, Timothy L., Derek Edward Murrell, and Stacy D. Brown. "Chromatographic Methods in Hiv Medicine: Application to Therapeutic Drug Monitoring." Digital Commons @ East Tennessee State University, 2018. https://doi.org/10.1002/bmc.4170.

Full text

Abstract:

HIV antiretroviral therapy spans several different drug classes, meant to combat various aspects of viral infection and replication. Many authors have argued the benefits of therapeutic drug monitoring (TDM) for the HIV patient including compliance assurance and assessment of appropriate drug concentrations; however, the array of drug chemistries and combinations makes TDM an arduous task. HPLC-UV and LC-MS/MS are both frequent instruments for the quantification of HIV drugs in biological matrices with investigators striving to balance sensitivity and affordability. Plasma, the dominant matrix

APA, Harvard, Vancouver, ISO, and other styles

27

Goswami, Ashwini. "DEVELOPMENT OF PPAR-γ RECEPTOR AGONISTS AS THERAPEUTIC AGENTS FOR DIABETES". VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1881.

Full text

Abstract:

The peroxisome proliferator-activated receptors (PPARs) are the transcriptional regulators of glucose, lipids and cholesterol metabolisms. It has been established that PPAR-γ is the receptor for thiazolidinediones (TZDs) class of type II anti-diabetic drugs. These compounds act as agonists of PPAR-γ. They may delay the development of type II diabetes in individuals at high risk of developing the condition, and have been shown to have potentially beneficial effects on cardiovascular risk factors. PPAR-γ receptor activation by TZDs improves insulin sensitivity by promoting fatty acid uptake into

APA, Harvard, Vancouver, ISO, and other styles

28

Meyer, Eric. "Comparative bioavailability and ranking of topical corticosteroid formulations." Thesis, Rhodes University, 1985. http://hdl.handle.net/10962/d1001471.

Full text

Abstract:

Numerous experiments in recent years have indicated differences in the bioavailability of corticosteroids from seemingly identical topical dosage forms. The human blanching assay was utilized in this study to assess the comparative blanching activities of various locally manufactured proprietary corticosteroid preparations. The first experiment was performed to assess the relative blanching activities of six semi - solid preparations containing the same concentration of betamethasone 17-valerate. The preparations used were Betnovate cream and ointment, Persivate cream and ointment and Celestod

APA, Harvard, Vancouver, ISO, and other styles

29

Öhman, Daniel. "Bioanalytical development for application in therapeutic drug monitoring : focus on drugs used in psychiatry /." Linköping : Univ, 2003. http://www.bibl.liu.se/liupubl/disp/disp2003/med775s.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Aldughaim, Mohammed. "The use of a novel TIMP3 peptide to specifically target therapeutic drugs to tumours." Thesis, University of Sheffield, 2017. http://etheses.whiterose.ac.uk/19957/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Verenich, Svetlana. "ROLE OF OXIDATIVE REACTIVE SPECIES AND ANTIOXIDANTS IN METABOLISM AND TRANSPORT OF THERAPEUTIC DRUGS." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/96.

Full text

Abstract:

Oxidative stress (OS) is a frequent complication of various disease conditions such as Alzheimer’s and Parkinson’s disease, atherosclerosis, preeclampsia, rheumatoid arthritis, diabetes including gestational diabetes, etc. OS is defined as an imbalance between the production of reactive species and the ability of an organism to detoxify the reactive intermediates and repair the damage. As a result of OS, the excess of reactive species such as oxygen superoxide (O2-), hydroxyl radical (OH), peroxynitrite (ONOO−), 4-hydroxynonenal (4HNE), etc., have a tendency to react with nearby proteins/nuc

APA, Harvard, Vancouver, ISO, and other styles

32

Komperlla, Mahesh Kumar. "The formulation and evaluation of rapid release tablets manufactured from Artemisia Afra plant material." Thesis, University of the Western Cape, 2004. http://etd.uwc.ac.za/index.php?module=etd&amp.

Full text

Abstract:

<p>Infusions, decoctions, alcoholic preparations and other dosage forms of Artemisia afra are frequently used in South African traditional medicine. Generally when these preparations are made without applying good manufacturing practices they do not meet microbial quality control standards, safety and toxicity criteria and encourage poor patients compliance. To overcome the aforementioned disadvantages of traditional dosage forms a sold dosage form, i.e. a table might be recommended. The first objective of this study was to formulate and manufacture a rapid release tablet dosage of Artemisia a

APA, Harvard, Vancouver, ISO, and other styles

33

Jones, Alison. "Modulation of the therapeutic index of chemotherapy and radiotherapy by cytotoxic drugs and biological agents." Thesis, University of Bristol, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299808.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Garrett, Ian Ross. "Studies of the effect of metal containing drugs on acute and chronic inflammation /." Title page, table of contents and summary only, 1986. http://web4.library.adelaide.edu.au/theses/09PH/09phg2386.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Pathy, Kala. "Bioavailability problems in clinical neuropharmacology with special reference to (1) generic phenytoin and (2) madopar HBS." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1994. http://hub.hku.hk/bib/B31214551.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Bethune, Claudette R. "The role of drug-lipid interactions in biodistribution and therapeutic effects for drugs incorporated into liposomes /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/7954.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Miller, Mark Russell. "The mechanism of action and therapeutic potential of S-nitrosothiols as novel nitric oxide donor drugs." Thesis, University of Edinburgh, 2003. http://hdl.handle.net/1842/24981.

Full text

Abstract:

Recently, two novel S-nitrosothiols, N-(S-nitroso-<i>N</i>-acetylpenicillamine)-2-amino-2-deoxy-1,3,4,6,tetra-<i>O</i>-acetyl-β-D-glucopyranose (RIG200) and S-nitroso-<i>N</i>-valerylpenicillamine (SNVP), have been described to have selectivity for endothelium-denuded blood vessels. Therefore, they are particularly appealing in the treatment of conditions where the vascular endothelium is damaged. This thesis describes experiments which further elucidate the mechanism of action and therapeutic of these novel S-nitrosothiols, by comparison to conventional NO donors. The key findings were that

APA, Harvard, Vancouver, ISO, and other styles

38

Leslie, Kristofer David. "The interaction of sequence-specific ligands with the nucleosome." Thesis, University of Southampton, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367975.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

Bylda, Caroline [Verfasser], and Dietrich A. [Akademischer Betreuer] Volmer. "Development of mass spectrometric methods for the quantitation of drugs of abuse and therapeutic drugs (DAT/TDM) in clinical samples / Caroline Bylda. Betreuer: Dietrich A. Volmer." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2015. http://d-nb.info/1074404580/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Dahm, Georges. "Metallocarbenes for therapeutic applications." Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAE037.

Full text

Abstract:

Les complexes métalliques des carbènes N-hétérocycliques (NHC) présentent un grand potentiel comme anticancéreux. En particulier, des études in vitro ont confirmés une cytotoxicité supérieure au cisplatine. Dans ce travail, nous avons introduit de la diversité moléculaire à de nouveaux complexes NHC-Pt par coordination de différents ligands NHC. Une deuxième stratégie, la post-fonctionnalisation de complexes de Pt a été étudié par : a) formation d’oxime, notamment avec une urée ciblant le PSMA, b) échange de ligand avec des polyamines hydrosolubles (PEI) ou des pnictogènes (phosphines, arsines

APA, Harvard, Vancouver, ISO, and other styles

41

Du, Plessis-Stoman Debbie. "A combination of platinum anticancer drugs and mangiferin causes increased efficacy in cancer cell lines." Thesis, Nelson Mandela Metropolitan University, 2010. http://hdl.handle.net/10948/d1016160.

Full text

Abstract:

This thesis mainly deals with some biochemical aspects regarding the efficacy of novel platinum anticancer compounds alone and in combination with mangiferin, as part of a broader study in which both chemistry and biochemistry are involved. Various novel diamine and N-S donor chelate compounds of platinum II and IV have been developed in which factors such as stereochemistry, ligand exchange rate and biocompatibility were considered as additional parameters. In the first order testing, each of these compounds was tested with reference to their “killing” potential by comparing their rate of kil

APA, Harvard, Vancouver, ISO, and other styles

42

Hung, Yik-fong Caroline, and 洪益芳. "A survey of albumin use by surgeons and ICU doctors in Hong Kong public hospitals." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B45010055.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Kalra, Jessica. "Integrin Linked Kinase as a therapeutic target for treating breast cancer : the value of using multiple endpoints to assess therapeutic effects of targeted drugs and drug combinations." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/27023.

Full text

Abstract:

Substantial preclinical evidence indicates that inhibition of Integrin Linked-Kinase (ILK) correlates with cytotoxic/cytostatic cellular effects, delayed tumour growth in animal models of cancer and inhibition of angiogenesis. It is increasingly evident that optimal therapeutic benefits obtained using ILK targeting strategies will only be achieved in combination settings. For this reason the therapeutic potential of the ILK small molecule inhibitor, QLT0267, alone or in combination with chemotherapies commonly used to treat breast cancer patients was investigated. The results suggested that th

APA, Harvard, Vancouver, ISO, and other styles

44

Chew, Angela Christine. "The anti-proliferative effects of thiazolidinediones and non-steriodal anti-inflammatory drugs on androgen-independent prostate cancer." University of Western Australia. School of Medicine and Pharmacology, 2009. http://theses.library.uwa.edu.au/adt-WU2009.0200.

Full text

Abstract:

[Truncated abstract] In recent years a better understanding of the biology of PPAR , a nuclear transcription factor, has emerged, leading to a resurgence in targeting PPAR for chemotherapy. The family of synthetic PPAR agonists, the thiazolidinediones (TZDs), and non-steroidal anti-inflammatory drugs (NSAIDs) have been implicated in the inhibition of cell proliferation, apoptosis and cell cycle arrest of androgen-sensitive (LNCaP) and androgen-independent (PC-3 and DU145) prostate cancer cells generating much interest in their use for potential curative cancer therapies. In light of the pote

APA, Harvard, Vancouver, ISO, and other styles

45

Tam, Chun-wai, and 談振偉. "Combating prostate diseases with ethnobotanical drugs: inhibition of prostate cancer cell proliferation by SawPalmetto (Serenoa repens) extracts." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B29188969.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Belotto, Karisa Cristina Rodrigues. "Comparação da bioequivalência de duas formulações da risperidona." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/5/5142/tde-08062010-152653/.

Full text

Abstract:

Desde 1964, o Brasil tem lançado programas de políticas públicas para melhorar o acesso da população aos medicamentos considerados essenciais. Em 1999, com a criação da Agência Nacional de Vigilância Sanitária e a introdução dos medicamentos genéricos no mercado brasileiro, o Brasil passou a ter três classes de medicamentos disponíveis no mercado farmacêutico: referência, similar e genérico. O objetivo deste estudo foi avaliar a bioequivalência e intercambialidade entre dois antipsicóticos (referência e similar) utilizados pelo Instituto de Psiquiatria do Hospital das Clínicas da Universidade

APA, Harvard, Vancouver, ISO, and other styles

47

Herbert, Natasha. "Individuals Who Sell Drugs Placed in Treatment: The Perspective of Their Counselors." ScholarWorks, 2019. https://scholarworks.waldenu.edu/dissertations/6333.

Full text

Abstract:

Individuals who sell drugs are often mandated by legal forces to substance abuse treatment because of their criminal offenses and the belief they may have a drug problem. Previous researchers have noted this population may be disruptive in the treatment process, but it has not been explored in depth. The purpose of this phenomenological study was to learn the lived experiences of counselors who work with individuals who report a primary problem of selling drugs, not substance abuse, who are mandated to a substance abuse treatment program. Thirteen semi structured interviews were conducted with

APA, Harvard, Vancouver, ISO, and other styles

48

Kwok, Hoi-shan, and 郭凱珊. "The comparison of biological properties of L- and D-enantiomeric antimicrobial peptides." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206507.

Full text

Abstract:

Antibiotics have been used widely for the treatment of bacterial infections for over half a century. However, the emergence of resistance to antibiotics has aroused public health concern, leading to the development of antimicrobial peptides (AMPs) as potential alternative therapeutic agents against bacterial infections. AMPs are naturally found in many species and have important roles in our innate immune defense systems. AMPs are usually cationic amphipathic peptides with membrane destabilizing property. They have a relatively broad spectrum of antimicrobial activity and pathogens are less li

APA, Harvard, Vancouver, ISO, and other styles

49

Chaibva, Faith Anesu. "Development and assessment of an oxytocin parenteral dosage form prepared using pluronic ® F127." Thesis, Rhodes University, 2007. http://hdl.handle.net/10962/d1003225.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Kritzinger, André Louis. "The medicinal chemistry of cyclo (Ser-Ser) and cyclo (Ser-Tyr)." Thesis, Nelson Mandela Metropolitan University, 2007. http://hdl.handle.net/10948/537.

Full text

Abstract:

Cyclic dipeptides are widely used as models for larger peptides because of their simplicity and limited conformational freedom. Some cyclic dipeptides have been shown to produce antiviral, antibiotic and anti-tumour activity (Milne et al., 1998). In this study the cyclic dipeptides, cyclo(Ser-Ser) and cyclo(Ser-Tyr), were synthesised from their corresponding linear precursors using a modified phenolinduced cyclisation procedure. The phenol-induced cyclisation procedure resulted in good yields and purity of the cyclic dipeptides. Quantitative analysis and evaluation of the physicochemical prope

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!