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Journal articles on the topic 'Therapeutic equivalency in drugs'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Wilner, Andrew N. "Therapeutic equivalency of generic antiepileptic drugs: results of a survey." Epilepsy & Behavior 5, no. 6 (2004): 995–98. http://dx.doi.org/10.1016/j.yebeh.2004.05.011.

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2

Rokita, Konrad, Grzegorz Cessak, Marta Dąbrowska, and Ewa Bałkowiec-Iskra. "Therapeutic equivalence of psychotropic drugs." Pharmacological Reports 67 (September 2015): 37. http://dx.doi.org/10.1016/j.pharep.2015.06.112.

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3

Schellekens, Huub, Ety Klinger, Stefan Mühlebach, Jean-Francois Brin, Gert Storm, and Daan J. A. Crommelin. "The therapeutic equivalence of complex drugs." Regulatory Toxicology and Pharmacology 59, no. 1 (2011): 176–83. http://dx.doi.org/10.1016/j.yrtph.2010.09.021.

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4

Verbeeck, R. K. "BIOEQUIVALENCE, THERAPEUTIC EQUIVALENCE AND GENERIC DRUGS." Acta Clinica Belgica 64, no. 5 (2009): 379–83. http://dx.doi.org/10.1179/acb.2009.063.

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5

Sakuma, A. "Evaluation of Clinical Equivalence of Therapeutic Drugs." Japanese Journal of Biometrics 15, no. 2 (1994): 73–74. http://dx.doi.org/10.5691/jjb.15.73.

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6

Rokita, K., E. Balkowiec-Iskra, and G. Cessak. "Bioequivalence and Therapeutic Equivalence of Psychotropic Drugs." European Psychiatry 30 (March 2015): 1594. http://dx.doi.org/10.1016/s0924-9338(15)31231-1.

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7

Cessak, Grzegorz, Konrad Rokita, and Ewa Bałkowiec-Iskra. "Bioequivalence and therapeutic equivalence of psychotropic drugs." Postępy Psychiatrii i Neurologii 24, no. 1 (2015): 8–17. http://dx.doi.org/10.1016/j.pin.2015.01.001.

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8

Santosh Kumar, Rada, and G. V. R. L. Soujanya. "Therapeutic Equivalence: A Connecting Link Between Test Drug and Reference Drug." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 829–31. http://dx.doi.org/10.22270/jddt.v9i4-s.3395.

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The concept of therapeutic equivalence is becoming increasingly important in today’s cost – conscious environment. Though an effective therapy already exists, but clinically equivalent therapy also becoming important. An improved toxicity profile better effects on symptoms and ease of administration may be important considerations. In these positive controls substantial effect is required to define equivalence. The goal is to prove that the new treatment is not inferior to standard, since providing that two treatments are equal is not possible. The superiority trials demonstrate the better eff

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9

Remport, Ádám, Dávid Dankó, Zsuzsa Gerlei, Krisztina Czebe, and István Kiss. "Special considerations in generic substitution of immunosuppressive drugs in transplantation." Orvosi Hetilap 153, no. 34 (2012): 1341–49. http://dx.doi.org/10.1556/oh.2012.29429.

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Long-term success in solid organ transplantation strongly depends on the optimal use of maintenance immunosuppressive treatment. Cyclosporin and tacrolimus are the most frequently administered immunosuppressants and they are designed to narrow therapeutic index drugs. The substitution of the branded formulation by their generic counterparts may lead to economic benefit only if equivalent clinical outcomes can be achieved. There is no published evidence to date on the guarantee of their long-term therapeutic equivalence and cases of therapeutic failures have been reported due to inadvertent dru

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10

Sankar, Raman, and Tracy A. Glauser. "Understanding Therapeutic Equivalence in Epilepsy." CNS Spectrums 15, no. 2 (2010): 112–23. http://dx.doi.org/10.1017/s1092852900027358.

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ABSTRACTThe issues surrounding generic drug substitution in patients with epilepsy are complex.The substitution of one formulation of an antiepileptic drug (AED) for another is controversial. Well-reasoned and defensible cases can be made both for and against such substitution. Although regulatory agencies require that generic and proprietary drugs have similar pharmacokinetic bioequivalence data, their therapeutic efficacy may not necessarily be identical. The paroxysmal nature of epilepsy, the narrow therapeutic index of some AEDs, the need to. individualize therapy to achieve seizure contro

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11

Johnston, Atholl. "Equivalence and interchangeability of narrow therapeutic index drugs in organ transplantation." European Journal of Hospital Pharmacy 20, no. 5 (2013): 302–7. http://dx.doi.org/10.1136/ejhpharm-2012-000258.

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12

Martsevich, S. Y., and S. Tolpygina. "Original drugs and their generics: a problem of choice." "Arterial’naya Gipertenziya" ("Arterial Hypertension") 15, no. 2 (2009): 209–13. http://dx.doi.org/10.18705/1607-419x-2009-15-2-209-213.

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The main distinctions of original and generic drugs are described, and the registration criteria of generics are given. The article considers the main causes of bioequivalence and therapeutic equivalence mismatch of original and generic medicines presenting several examples based on the results of clinical comparative studies, including Enalapril Maleate (comparison of original Renitec and generic Enam). The main approaches of planning the therapeutic equivalence comparative studies are offered.

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13

Gómez Sánchez-Lafuente, C. "11 Therapeutic Equivalences in Long-term Antipsychotics." CNS Spectrums 24, no. 1 (2019): 178–79. http://dx.doi.org/10.1017/s1092852919000075.

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AbstractStudy ObjectivesThe concept of dose equivalence is very useful when it comes to using drugs. In the case of antipsychotics, the first comparison was established by Davis in 1974, called the classical comparison method. Subsequently, other methods have appeared, such as the minimum effective dose method, the dose response method, the consensus among experts such as consensus method by Gardner, and the Daily Dose method of the World Health Organization. In 2016, Leucht et al performed the meta-analysis comparing the equivalence by the alternative methods of second-generation antipsychoti

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14

Dukhanin, A. S. "Correlation of reference and generic fluconazole-based drugs." Meditsinskiy sovet = Medical Council, no. 3 (April 17, 2020): 98–104. http://dx.doi.org/10.21518/2079-701x-2020-3-98-104.

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The article describes the basic rules for the selection of a systemic antifungal drug from the fluconazole-based preparations available on the Russian pharmaceutical market. Questions of interchangeability of generic and original drugs, research of equivalence (pharmaceutical, pharmacokinetic), possible methodological difficulties of its estimation are discussed. Data on comparative analysis of original and generic fluconazole drugs are presented. The algorithm of rational choice of a drug on an example of fluconazole is formulated, property of a drug to suppress selectively activity of fungi

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15

Romodanovsky, D. P. "Relevant Issues of Planning Bioequivalence Studies of Drugs with a Narrow Therapeutic Range." Bulletin of the Scientific Centre for Expert Evaluation of Medicinal Products 10, no. 3 (2020): 201–10. http://dx.doi.org/10.30895/1991-2919-2020-10-3-201-210.

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In order to be registered, generic drugs with a narrow therapeutic range have to undergo bioequivalence or therapeutic equivalence studies. In most cases, comparative pharmacokinetic studies and demonstration of bioequivalence between the test and the reference products are sufficient for this group of drugs. However, there is no established official definition in Russia for the group of drugs that are regarded as having a narrow therapeutic range. Evaluation of bioequivalence of such drugs has to be performed providing for narrower confidence intervals, which entails certain problems at the s

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16

Gagne, Joshua J., Jennifer M. Polinski, Wenlei Jiang, et al. "Outcomes Associated with Generic Drugs Approved Using Product-Specific Determinations of Therapeutic Equivalence." Drugs 77, no. 4 (2017): 427–33. http://dx.doi.org/10.1007/s40265-017-0696-2.

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17

Bae, Kyun-Seop, In-Jin Jang, and Sang-Goo Shin. "Regulatin and Management of Generic Drugs to Assure Therapeutic Equivalence in the United States." Journal of Korean Society for Clinical Pharmacology and Therapeutics 9, no. 1 (2001): 3. http://dx.doi.org/10.12793/jkscpt.2001.9.1.3.

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18

Gagne, Joshua J., Jennifer M. Polinski, Wenlei Jiang, et al. "Switch-backs associated with generic drugs approved using product-specific determinations of therapeutic equivalence." Pharmacoepidemiology and Drug Safety 25, no. 8 (2016): 944–52. http://dx.doi.org/10.1002/pds.4009.

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19

Arkhipov, V. V., E. A. Sokova, G. I. Gorodetskaya, O. A. Demidova, and T. V. Aleksandrova. "New Anticonvulsants: Interchangeability Issues and the Use of Generic Anticonvulsants in Clinical Practice." Bulletin of the Scientific Centre for Expert Evaluation of Medicinal Products 9, no. 2 (2019): 101–7. http://dx.doi.org/10.30895/1991-2919-2019-9-2-101-107.

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This article looks into interchangeability and therapeutic equivalence of innovator and generic anticonvulsants — the first-generation and new antiepileptic drugs (AEDs). The results of a number of clinical trials assessing therapeutic equivalence of generic AEDs support the opinion that these medicines could only be substituted provided an ultra-cautious approach is used, even if the case involves only one International Nonproprietary Name, including, but not limited to different dosage forms of one and the same product. The aim of the study was to analyse factors leading to incorrect assessm

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20

Paumgartten, Francisco José Roma, and Ana Cecilia Amado Xavier de Oliveira. "Nonbioequivalent prescription drug interchangeability, concerns on patient safety and drug market dynamics in Brazil." Ciência & Saúde Coletiva 22, no. 8 (2017): 2549–58. http://dx.doi.org/10.1590/1413-81232017228.04352017.

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Abstract Since the enforcement of Generics Act (1999), three types of pharmaceutically equivalent products are marketed in Brazil: innovative reference (REF), “similar” (S) and generic (G) drugs. The S (brand name) and G (generic name) borrow from REF (brand name) clinical data on safety and efficacy and dosage regimen. G (but not S) is bioequivalent to and interchangeable with REF. Starting in 2003, Brazilian Sanitary Surveillance Agency (Anvisa) has required data on relative bioavailability tests (with REF) to approve (or renew registration of) S drugs. In 2014, Anvisa extended interchangeab

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21

Larina, Vera N. "Complex therapy of a multimorbid patient: focus on the reproducible drugs." Consilium Medicum 23, no. 6 (2021): 498–503. http://dx.doi.org/10.26442/20751753.2021.6.200922.

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Chronic noncommunicable diseases are associated with high mortality and high costs of medical care, and therefore require safe, effective and affordable therapy. When choosing a generic drug, a doctor may be guided by the assumption that the bioequivalence of medicinal substances is an indirect confirmation of their therapeutic efficacy. Absolute confidence in the same efficacy of original and generic drugs can only emerge after welldesigned studies comparing therapeutic equivalence. The results of the Russian multicenter, open, randomized KARDIOKANON study, the purpose of which was to compare

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22

Gagne, Joshua J., Jennifer M. Polinski, Wenlei Jiang, et al. "Correction to: Outcomes Associated with Generic Drugs Approved Using Product-Specific Determinations of Therapeutic Equivalence." Drugs 78, no. 4 (2018): 523–24. http://dx.doi.org/10.1007/s40265-018-0890-x.

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23

Dutt, Manisha, and G. K. Khuller. "Therapeutic Efficacy of Poly(dl-Lactide-Co-Glycolide)-Encapsulated Antitubercular Drugs against Mycobacterium tuberculosis Infection Induced in Mice." Antimicrobial Agents and Chemotherapy 45, no. 1 (2001): 363–66. http://dx.doi.org/10.1128/aac.45.1.363-366.2001.

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ABSTRACT Poly(dl-lactide-co-glycolide) (PLG) microparticles were developed as carriers for isoniazid and rifampin in order to improve compliance of tuberculous chemotherapy. Antitubercular drugs encapsulated in PLG polymers and injected in a single dose subcutaneously resulted in a sustained release (up to 6 weeks) of drugs in various organs of mice. Further, Mycobacterium tuberculosis H37Rv-infected animals given a single shot of chemotherapy in PLG microparticles exhibited a better or equivalent clearance of CFU in various organs compared to those given a daily administration of free drugs.

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24

Gomes Freitas, Carolina, Michael Walsh, Enia Lucia Coutinho, Angelo Amato Vincenzo de Paola, and Álvaro Nagib Atallah. "Examining therapeutic equivalence between branded and generic warfarin in Brazil: The WARFA crossover randomized controlled trial." PLOS ONE 16, no. 4 (2021): e0248567. http://dx.doi.org/10.1371/journal.pone.0248567.

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Objectives To determine whether the generic and branded warfarins used as anticoagulants in Brazil are therapeutic equivalents based on their international normalized ratio (INR) results. Methods This crossover randomized controlled trial had four periods. We used the branded Marevan and two generic versions of warfarin sodium tablets, manufactured by União Química and Teuto laboratories, all purchased from retail drugstores. Eligible participants were outpatients from an anticoagulation clinic at a university hospital in São Paulo, Brazil. They had atrial fibrillation or flutter and had been

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25

Sun, Zhuo, Ji Jiang, and Xia Chen. "Evaluation of Therapeutic Equivalence for the Follow-On Version of Intravenously Administered Non-Biological Complex Drugs." Clinical Pharmacokinetics 59, no. 8 (2020): 995–1004. http://dx.doi.org/10.1007/s40262-020-00889-9.

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26

Malhotra, Sameer, Adam D. Cheriff, J. Travis Gossey, Curtis L. Cole, Rainu Kaushal, and Jessica S. Ancker. "Effects of an e-Prescribing interface redesign on rates of generic drug prescribing: exploiting default options." Journal of the American Medical Informatics Association 23, no. 5 (2016): 891–98. http://dx.doi.org/10.1093/jamia/ocv192.

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Abstract Objective Increasing the use of generic medications could help control medical costs. However, educational interventions have limited impact on prescriber behavior, and e-prescribing alerts are associated with high override rates and alert fatigue. Our objective was to evaluate the effect of a less intrusive intervention, a redesign of an e-prescribing interface that provides default options intended to “nudge” prescribers towards prescribing generic drugs. Methods This retrospective cohort study in an academic ambulatory multispecialty practice assessed the effects of customizing an

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27

Tu, Dongsheng. "A Comparative Study of Some Statistical Procedures in Establishing Therapeutic Equivalence of Nonsystemic Drugs with Binary Endpoints." Drug Information Journal 31, no. 4 (1997): 1291–300. http://dx.doi.org/10.1177/009286159703100428.

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28

Lahrtz, Fritz. "How to Successfully Patent Therapeutic Antibodies." Journal of Biomolecular Screening 20, no. 4 (2015): 484–91. http://dx.doi.org/10.1177/1087057114567457.

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Therapeutic antibodies have become an established class of drugs for the treatment of a variety of diseases, especially cancer and autoimmune/inflammatory disorders, and a sufficient patent protection is a prerequisite for their successful commercialization. As monoclonal antibodies and their therapeutic potential have been well known for decades, the mere production of yet another therapeutic antibody is in many jurisdictions not considered a patentable invention. In contrast, antibodies with novel structural features and/or improved properties may be patentable. When drafting the claims, car

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Marshall, Tessa, Hok Lim, and Phyllis Lau. "Patient views of therapeutic interchange of ACE inhibitors in Australian primary care: a qualitative study." BMJ Open 11, no. 7 (2021): e044806. http://dx.doi.org/10.1136/bmjopen-2020-044806.

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ObjectivesIn Australia, therapeutic interchange of angiotensin-converting enzyme (ACE) inhibitors could generate savings for patients and the Pharmaceutical Benefits Scheme (PBS). The PBS subsidises nine drugs in the ACE inhibitor class. These drugs are therapeutically equivalent, but the price varies between each drug. Patients are key players in successful therapeutic interchange programmes, but little is known about their views. This study aims to explore patient views of therapeutic interchange of ACE inhibitors in Australian primary care.DesignQualitative exploratory research study using

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30

Spasovski, Goce. "Generic Drugs – Decreasing Costs and Room for Increased Number of Kidney Transplantations." PRILOZI 36, no. 2 (2015): 133–38. http://dx.doi.org/10.1515/prilozi-2015-0061.

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Abstract Kidney transplantation is the best treatment option in comparison to dialysis, although patients are obliged to receive life-long medical treatment with immunosuppressive drugs (ISDs) for prevention of the graft rejection. Such immunosuppressive treatment may be costly and associated with multiple adverse effects. Since costs are viewed as one of the major constraints for the increasing number of transplantation, the use of generic ISDs may decrease the overall cost of transplantation and raise the possibility for its further development. An ideal ISD should have the security margin b

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Khodzhaev, N. S., and A. V. Starostina. "To the question about rational choice between original and generic drugs: arguments to use the first." Russian Ophthalmological Journal 12, no. 2 (2019): 106–11. http://dx.doi.org/10.21516/2072-0076-2019-12-2-106-111.

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Issues of safety and efficacy of drugs attracts much attention worldwide. The growing use of generics and the lack of stringent requirements to research focused on their biological and therapeutic equivalence are causing concern of ophthalmologists. The literary review presents hypotensive properties and physical characteristics of the major original and generic hypotensive eye drops.

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Blier, Pierre. "Generic Substitution for Psychotropic Drugs." CNS Spectrums 14, no. 9 (2009): 1–7. http://dx.doi.org/10.1017/s1092852900024706.

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Most antidepressants and other psychotropics in clinical use are available as generic formulations (Table). The availability of lower-priced, generic drugs can benefit patients and third-party payers, but it should not be assumed that all generic drugs are equally beneficial. There are numerous reports in the literature of unexpected and untoward consequences that occur when a generic drug is substituted for the original brand-name drug. A previously stable clinical response may suddenly deteriorate, or the patient may experience new or more severe adverse events (AEs). The United States Food

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Eandi, Mario, and Carlo Della Pepa. "I farmaci “generici” in Italia: opportunità di ricerca e sviluppo di prodotti di qualità a prezzi competitivi." Farmeconomia. Health economics and therapeutic pathways 4, no. 2 (2003): 65–76. http://dx.doi.org/10.7175/fe.v4i2.770.

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Every drug whose copyright coverage has expired can be manufactured by a pharmaceutical company other than the one that developed it, giving rise to the market of the so-called generic drugs. It can be distinguished among two types of generic drugs: branded and unbranded, according to the choice of the manufacturer to assign it a fantasy name or to sell it with the name of the active principle, followed by the company’s name. In order to be accepted for marketing, every new drug has to pass the registration procedures of the Italian Ministry of Health, which are simplified for generics, as it’

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González, Claudia Patricia Vacca, James F. Fitzgerald, and Joan Rovira. "Generics in Latin America: Trends and Regulation." Journal of Generic Medicines: The Business Journal for the Generic Medicines Sector 6, no. 1 (2008): 43–56. http://dx.doi.org/10.1057/jgm.2008.32.

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The purpose of this study was to establish regulatory trends related to competing drugs in several Latin American and Caribbean countries and to review regulations and national policies on generic drugs in these countries. Furthermore, information on the incentives to register and produce competing drugs, the promotion of international non-proprietary name (INN) use, the regulation of bioequivalence studies and the substitution of drugs prescribed by lower price alternatives to the public was also obtained. The results showed three regulatory categories: those countries that favour financing o

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Morosyuk, Svetlana, Julie Berube, Robert Christenson, et al. "A Multicenter Evaluation of a Nongel Mechanical Separator Plasma Blood Collection Tube for Testing of Selected Therapeutic Drugs." Journal of Applied Laboratory Medicine 5, no. 4 (2020): 671–85. http://dx.doi.org/10.1093/jalm/jfaa033.

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Abstract Background Some therapeutic drugs are unstable during sample storage in gel tubes. BD Vacutainer® Barricor™ Plasma Blood Collection Tube with nongel separator was compared with plasma gel tubes, BD Vacutainer PST™, PST II, and BD Vacutainer Serum Tube for acetaminophen, salicylate, digoxin, carbamazepine, phenytoin, valproic acid, and vancomycin during sample storage for up to 7 days. Methods Seven hospital sites enrolled 705 participants who were taking at least one selected drug. The study tubes were collected and tested at initial time (0 h), after 48 h of storage at room temperatu

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Cheng, Hongwei, Paul W. Clarkson, Dongxia Gao, Marina Pacheco, Yuzhuo Wang, and Torsten O. Nielsen. "Therapeutic Antibodies Targeting CSF1 Impede Macrophage Recruitment in a Xenograft Model of Tenosynovial Giant Cell Tumor." Sarcoma 2010 (2010): 1–7. http://dx.doi.org/10.1155/2010/174528.

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Tenosynovial giant cell tumor is a neoplastic disease of joints that can cause severe morbidity. Recurrences are common following local therapy, and no effective medical therapy currently exists. Recent work has demonstrated that all cases overexpress macrophage colony-stimulating factor (CSF1), usually as a consequence of an activating gene translocation, resulting in an influx of macrophages that form the bulk of the tumor. New anti-CSF1 drugs have been developed; however there are no preclinical models suitable for evaluation of drug benefits in this disease. In this paper, we describe a no

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Möller, HJ. "Therapeutic strategies in atypical depression. A German perspective." European Psychiatry 8, no. 5 (1993): 273–76. http://dx.doi.org/10.1017/s0924933800000341.

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SummaryIn Germany a major distinction is made between endogenous and neurotic depression. While traditionally neurotic depression was seen as being amenable only to psychotherapy, there is an increasing tendency to treat neurotic patients presenting the full depressive syndrome with antidepressant drugs. Those psychiatrists who are aware of the concept of atypical depression in the stricter sense (anxiety-depression, depression with reversed somatic symptoms, etc) tend to treat these patients with monoamine oxidase inhibitors. The diagnosis of “dysthymia”, Possibly equivalent to “neurotic depr

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di Punzio, Giulia, Maria Antonietta Di Noia, Agnès Delahodde, et al. "A Yeast-Based Screening Unravels Potential Therapeutic Molecules for Mitochondrial Diseases Associated with Dominant ANT1 Mutations." International Journal of Molecular Sciences 22, no. 9 (2021): 4461. http://dx.doi.org/10.3390/ijms22094461.

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Mitochondrial diseases result from inherited or spontaneous mutations in mitochondrial or nuclear DNA, leading to an impairment of the oxidative phosphorylation responsible for the synthesis of ATP. To date, there are no effective pharmacological therapies for these pathologies. We performed a yeast-based screening to search for therapeutic drugs to be used for treating mitochondrial diseases associated with dominant mutations in the nuclear ANT1 gene, which encodes for the mitochondrial ADP/ATP carrier. Dominant ANT1 mutations are involved in several degenerative mitochondrial pathologies cha

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Messori, Andrea, Valeria Fadda, and Sabrina Trippoli. "‘Therapeutic Alternatives’: Procurement Rules for Drugs with Same Indication but without Equivalence Certification Released According to the Balduzzi Law." Global & Regional Health Technology Assessment: Italian; Northern Europe and Spanish 2, no. 3 (2015): GRHTA.5000202. http://dx.doi.org/10.5301/grhta.5000202.

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Doering, Paul L., Wayne L. Russell, William C. McCormick, and Deborah L. Klapp. "Therapeutic Substitution in the Health Maintenance Organization Outpatient Environment." Drug Intelligence & Clinical Pharmacy 22, no. 2 (1988): 125–30. http://dx.doi.org/10.1177/106002808802200204.

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Health maintenance organizations (HMO) are growing in number as a cost-effective way of providing health care. In some, stringent formulary management policies including programs authorizing therapeutic substitution are practiced. Under this concept a drug that has been previously determined to be therapeutically equivalent to a second drug, even though it is not chemically equivalent to the prescribed drug, is automatically dispensed without contacting the prescriber. This study was undertaken to learn the extent and conditions under which therapeutic substitution is being practiced in the HM

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Detsky, Allan S. "Establishing Therapeutic Equivalency." Archives of Internal Medicine 146, no. 5 (1986): 861. http://dx.doi.org/10.1001/archinte.1986.00360170057006.

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Chesi, Marta, Victoria Garbitt, and P. Leif Bergsagel. "Identification of Novel Therapeutic Targets in the Clinically Predictive Vk*MYC Mouse Model of Multiple Myeloma." Blood 124, no. 21 (2014): 415. http://dx.doi.org/10.1182/blood.v124.21.415.415.

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Abstract A genetic rearrangement of the MYC locus, resulting in dysregulated expression of MYC, is the most common mutation in human multiple myeloma (MM). The genetically engineered Vk*MYC mouse model is based on dysregulation of MYC, and has been extensively validated as a clinically and biologically faithful model of untreated MM. We previously reported 9 drugs or classes of drugs (DNA alkylators, glucocorticoids, proteasome inhibitors, IMiDs, nab-paclitaxel, histone deacetylase inhibitors, TACI-Ig, perifosine and SNS-032, a CDK2,7,9 inhibitor) with more than 20% partial response (PR) rate

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Deprez, Valentine, Laure Le Monnier, Jean-Marc Sobhy-Danial, et al. "Therapeutic Maintenance of Baricitinib and Tofacitinib in Real Life." Journal of Clinical Medicine 9, no. 10 (2020): 3319. http://dx.doi.org/10.3390/jcm9103319.

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Background: Janus kinase inhibitors (JAKis) represent a new alternative to treat rheumatoid arthritis (RA). The objective of this study was to evaluate the effectiveness, tolerance profile, and maintenance of these treatments (tofacitinib and baricitinib) in real life. Methods: All patients in the rheumatology department of Amiens University Hospital treated by JAKis for RA were included from 1 October 2017 to 20 May 2020. Clinical and biological data were provided retrospectively in this observational and single-center study. We aimed to study the JAKi maintenance rate at 12 months and their

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Langer, Florian, Emmanuel J. Favaloro, and Giuseppe Lippi. "Direct Oral Anticoagulants for Disseminated Intravascular Coagulation: An Alliterative Wordplay or Potentially Valuable Therapeutic Interventions?" Seminars in Thrombosis and Hemostasis 46, no. 04 (2019): 457–64. http://dx.doi.org/10.1055/s-0039-3402478.

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AbstractDisseminated intravascular coagulation (DIC) is a relatively rare but life-threatening condition, the outcome of which depends largely on timely and accurate therapeutic management. Inhibiting the activation of blood coagulation is an effective option for limiting the burden of diffuse intravascular thrombosis for attenuating consumption of clotting factors and platelets and ultimately preventing massive bleeding. Direct oral anticoagulants (DOACs) are a relatively new generation of drugs that specifically inhibit activated factors II (thrombin) and X, thus providing effective anticoag

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Chee, D., R. Nice, B. Hamilton, et al. "P181 Patient-led remote intracapillary pharmacokinetic sampling (fingerPRICKS) for therapeutic drug monitoring in patients with Inflammatory Bowel Disease." Journal of Crohn's and Colitis 15, Supplement_1 (2021): S252. http://dx.doi.org/10.1093/ecco-jcc/jjab076.308.

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Abstract Background Because of COVID-19 public health restrictions, telemedicine has replaced conventional outpatient follow up for most patients with chronic immune-mediated inflammatory disorders treated with biologic drugs. Innovative solutions to facilitate remote therapeutic drug monitoring are therefore required. Low-volume intracapillary blood sampling can be undertaken by patients at home and samples returned by post to central laboratories. Methods We sought to report the effect of the COVID-19 pandemic on requests for therapeutic drug monitoring and the equivalence, acceptability and

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Lacoeuille, Franck, Emmanuel Garcion, Jean-Pierre Benoit, and Alf Lamprecht. "Lipid Nanocapsules for Intracellular Drug Delivery of Anticancer Drugs." Journal of Nanoscience and Nanotechnology 7, no. 12 (2007): 4612–17. http://dx.doi.org/10.1166/jnn.2007.18114.

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As non-phagocytic eukaryotic cells can internalize particles <1 μm in size, small size (25 to 110 nm) lipid nanocapsules (LNC) are proposed for the intracellular drug delivery of anticancer drugs to cancer cells. LNC ofdifferent diameters were loaded with etoposide or paclitaxel and subsequently tested for drug release kinetics and their efficiency to reduce cancer cell growth in cell culture. Relative high drug loads could be achieved and sustained drug release can be provided over a period ofseveral days (etoposide) up to a few weeks (paclitaxel). While particle size exhibited only minor

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Moraes, Carolina B., Karen L. White, Stéphanie Braillard, et al. "Enantiomers of Nifurtimox Do Not Exhibit Stereoselective Anti-Trypanosoma cruzi Activity, Toxicity, or Pharmacokinetic Properties." Antimicrobial Agents and Chemotherapy 59, no. 6 (2015): 3645–47. http://dx.doi.org/10.1128/aac.05139-14.

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ABSTRACTWith the aim of improving the available drugs for the treatment of Chagas disease, individual enantiomers of nifurtimox were characterized. The results indicate that the enantiomers are equivalent in theirin vitroactivity against a panel ofTrypanosoma cruzistrains;in vivoefficacy in a murine model of Chagas disease;in vitrotoxicity and absorption, distribution, metabolism, and excretion characteristics; andin vivopharmacokinetic properties. There is unlikely to be any therapeutic benefit of an individual nifurtimox enantiomer over the racemic mixture.

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Perry, Martin, Azhar Abdullah, Marina Frleta, Jonathan MacDonald, and Andrew McGucken. "The potential value of blood monitoring of biologic drugs used in the treatment of rheumatoid arthritis." Therapeutic Advances in Musculoskeletal Disease 12 (January 2020): 1759720X2090485. http://dx.doi.org/10.1177/1759720x20904850.

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The advent of biological therapies has been a major therapeutic advance in rheumatology. Many patients now enjoy improved quality of life through better disease control. The number of therapies continues to grow both within drug class (including biosimilar drugs) and via new mechanisms. For the first time, nonbiological drugs such as small-molecule inhibitors (Janus kinase inhibitors) have shown clinical equivalence. However, clinical unmet need remains with up to a third of patients commenced on a biologic therapy having minimal or no response: (a) Generally, the first biologic used secures t

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Amigó, Salvador, Joan C Micó, and Antonio Caselles. "LEARNING TO BE A PSYCHOSTIMULANTS ADDICT WITH SELF-REGULATION THERAPY." Revista Internacional de Sistemas 22, no. 1 (2018): 13. http://dx.doi.org/10.7203/ris.22.1.11486.

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This article presents the results of a single-case experiment of alternative treatments in which a participant applied the Self-Regulation Therapy (SRT) to reproduce the effects of a stimulant drug, methylphenidate, and a sedative, alcohol. The SRT is a learning procedure based on classic conditioning and suggestion that reproduces the effect of drugs by remembering the effects they have. The participant reproduced the effects of both drugs during ten sessions held on 5 consecutive days. To record effects, adjective scales were used that measured Drug effect, High, Rush, Energy, Tension and th

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Danilenko, A. A., S. V. Shakhtarina, and N. A. Falaleeva. "MODERN APPROACHES TO TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA." Siberian journal of oncology 19, no. 6 (2020): 106–18. http://dx.doi.org/10.21294/1814-4861-2020-19-6-106-118.

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Purpose of the study: to systematize published data on the effectiveness of drugs used to treat patientswith chronic lymphocytic leukemia.Material and Methods. A literature search was conducted using Medline, Pubmed databases. 93 publications were selected to write this review.Results. General information about chronic lymphocytic leukemia (biological features, criteria for establishing diagnosis, staging, criteria for evaluating antitumor therapy response) was presented. The focus was made on antitumor drugs used as monotherapy and in combination with other anti-cancer agents. The use of drug

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