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Dissertations / Theses on the topic 'Therapeutic peptide'

Author: Grafiati

Published: 4 June 2021

Last updated: 16 February 2022

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1

Krysmann, Marta J. "Self-assembly of peptides and peptide based hybrids for therapeutic applications." Thesis, University of Reading, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558793.

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A rich gallery of novel systems based on the sequence KLVFF (namely KLVFF, FFKLVFF, AAKLVFF, AAKLVAA, βAβAKLVFF, KLVFF-PEG, FFKLVFF-PEG, AAKLVFF-PEG, AAKLVAA-PEG, FF-PEG, FFFF-PEG) was synthesized and characterized. For the first time structure-properties relationships of this class of materials were systematically explored, with emphasis on self-association properties in both bulk and solution. Such a comparative investigation, essentially absent from the literature, provides insights into the underlying mechanism of amyloid fibrogenesis, given that KL VFF has been identified as critical for

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2

Roberts, David John. "Peptide based conjugates for therapeutic delivery applications." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/peptide-based-conjugates-for-therapeutic-delivery-applications(76cee616-80bf-4b31-89d1-63f699573e78).html.

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The effect of peptide charge on the self-assembly and gelation behaviour of three octa-peptides: VEVKVEVK (VEK2), VKVKVEVK (VEK3) and VEVEVKVE (VEK1) has been investigated and characterised. The critical gelation concentration of each peptide was found to correlate with the charge modulus carried by the peptide and to be independent of the sign of the charge. Hydrogels formed were found to be transparent and stable when the peptide charge modulus is > 1. No differences in hydrogel structure or mechanical properties, as probed by TEM and SAXS and shear rheology, were found when the peptides wer

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3

Kilian, Gareth. "Development and testing of liposome encapsulated cyclic dipeptides." Thesis, Nelson Mandela Metropolitan University, 2011. http://hdl.handle.net/10948/1397.

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Cyclic dipeptides have been well characterized for their multitude of biological activities, including antimicrobial and anticancer activities. Cyclo(His-Gly) and cyclo(His-Ala) have also recently been shown to possess significant anticancer activity against a range of cell lines, despite the limitations of these two molecules with respect to their physicochemical properties. Low Log P results in poor cell permeability which can often be problematic for drugs with intracellular mechanisms of action. It can also results in poor biodistribution, and theoretical Log P values for cyclo(His-Gly) an

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4

Ngwa, Conelius. "Use of peptide nucleic acids as therapeutic agents." Thesis, Aston University, 2014. http://publications.aston.ac.uk/24385/.

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5

Qian, Yun. "Self-assembled Peptide Hydrogels for Therapeutic H2S Delivery." Diss., Virginia Tech, 2019. http://hdl.handle.net/10919/101094.

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Hydrogen sulfide (H2S) is a gasotransmitter that is produced endogenously and freely permeates cell membranes. It plays important roles in many physiological pathways, and by regulating these pathways, it provides many therapeutic effects. For example, H2S dilates vascular vessels, promotes angiogenesis, and protects cells from oxidative stress. Due to its therapeutic effects, H2S has been used as a potential treatment for diseases like diabetes, ischemia-reperfusion injuries, lung diseases, ulcers and edemas, among others. To apply H2S for therapeutic applications, two challenges need to be

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6

Parker, Alan. "Development of peptide-targeted gene delivery systems." Thesis, University of Birmingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273727.

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7

Tasdemiroglu, Yagmur. "Small Therapeutic Peptides: In vitro pharmacokinetics of alpha-carboxyl terminus 11 peptide in rat plasma." Thesis, Virginia Tech, 2021. http://hdl.handle.net/10919/103639.

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Cardiovascular diseases affect one third of the U.S. population and are the number one cause of death globally. Acute myocardial infarction is one of the most catastrophic cardiovascular diseases that permanently alters patient's lives. Small molecule drugs, surgery, medical devices and lifestyle changes are the current treatment methods that only address symptoms and fail to cure cardiovascular disorders. Small therapeutic peptides are emerging methods to treat diseases ranging from cancer to auto-immune disorders. Due to their nature, they are non-toxic, non-immunogenic, biocompatible and hi

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8

Barrios, Marrugo Kelly. "Therapeutic Peptide-Based Vaccination Strategies Against HPV-Induced Cancers." Scholar Commons, 2012. http://scholarcommons.usf.edu/etd/4283.

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There is an urgent need for the development of an effective therapeutic vaccine against cancer caused by human papilloma virus (HPV). We focused on HPV-induced malignancies because of their high worldwide prevalence (e.g., cervical carcinoma and head & neck cancer). A successful therapeutic vaccine could prevent the 250 000 deaths/year worldwide and the 2.25 billion dollars that are expended in related care in the US. We used an HPV-induced mouse cancer model to test vaccines composed of a CD8 T cell peptide epitope administered with potent adjuvants designed to generate vast numbers of high a

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9

Kwok, Hoi-shan, and 郭凱珊. "The comparison of biological properties of L- and D-enantiomeric antimicrobial peptides." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206507.

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Antibiotics have been used widely for the treatment of bacterial infections for over half a century. However, the emergence of resistance to antibiotics has aroused public health concern, leading to the development of antimicrobial peptides (AMPs) as potential alternative therapeutic agents against bacterial infections. AMPs are naturally found in many species and have important roles in our innate immune defense systems. AMPs are usually cationic amphipathic peptides with membrane destabilizing property. They have a relatively broad spectrum of antimicrobial activity and pathogens are less li

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10

Makhani, Kiran, and Kiran Makhani. "Mechanism of Action of ERBB Decoy Cancer Therapeutic Peptide SAH5." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/626139.

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Breast cancer is the most prevalent type of cancer and second leading cause of death in women. Among others, the triple negative breast cancer (TNBC) is the most invasive as it has the highest recurrence and death rates with no targeted therapeutic available thus far. Epidermal Growth Factor Receptor (EGFR) is one of the important targets as more than fifty percent of the TNBC overexpress it but all the therapies designed against it have failed to show significant results. The juxtamembrane domain of EGFR has been explored comparatively recently and has been used to design a decoy peptide with

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11

Park, Kwijun. "Therapeutic potential of atrial natriuretic peptide administration on peripheral arterial diseases." Kyoto University, 2008. http://hdl.handle.net/2433/135849.

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12

Kritzinger, André Louis. "The medicinal chemistry of cyclo (Ser-Ser) and cyclo (Ser-Tyr)." Thesis, Nelson Mandela Metropolitan University, 2007. http://hdl.handle.net/10948/537.

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Cyclic dipeptides are widely used as models for larger peptides because of their simplicity and limited conformational freedom. Some cyclic dipeptides have been shown to produce antiviral, antibiotic and anti-tumour activity (Milne et al., 1998). In this study the cyclic dipeptides, cyclo(Ser-Ser) and cyclo(Ser-Tyr), were synthesised from their corresponding linear precursors using a modified phenolinduced cyclisation procedure. The phenol-induced cyclisation procedure resulted in good yields and purity of the cyclic dipeptides. Quantitative analysis and evaluation of the physicochemical prope

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13

Riaz, Muhammad Kashif. "Peptide functionalized drug delivery system for an efficient lung cancer therapy." HKBU Institutional Repository, 2019. https://repository.hkbu.edu.hk/etd_oa/609.

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Lung cancer has a high incidence rate globally and the leading cause of cancer related mortalities. In 2018, lung cancer has been estimated to cause 1.76 million deaths worldwide (18.33% of total cancer mortalities). In Hong Kong lung cancer has been a leading cause of cancer related deaths, and in 2016 caused 3780 deaths (26.6% of total cancer mortalities). Non-small cell lung cancer (NSCLC) is the major (~85%) lung cancer type, and five-year survival rate for lung cancer has estimated to be 18%. Thus, an efficient lung cancer treatment with lesser adverse effects is need of the hour. In this

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14

Su, Hsin-Yuan. "Therapeutic Potential of EGFR Derived Peptides in Breast Cancer." Diss., The University of Arizona, 2013. http://hdl.handle.net/10150/293486.

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The epidermal growth factor receptor (EGFR) belongs to the erbB family of receptor tyrosine kinases which consists of four members (EGFR, ErbB2, ErbB3 and ErbB4). Upon ligand binding, the EGFR is capable of dimerization with other erbB receptors and propagates signals regulating a diverse array of cellular physiologies, including cell growth, migration and survival. Dysregulation of the EGFR is important for development and progression of different types of cancers, including breast cancer. Breast cancer is the second leading cause of cancer death in women. EGFR overexpression has been observ

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15

Konkel, Joanne Elizabeth. "Signals required for the induction of antigen-based therapeutic tolerance." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/3942.

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Despite the actions of central tolerance during thymic selection, it is clear that the peripheral T cell repertoire contains significant numbers of self-reactive T cells. The immune system needs to curtail the risk of autoimmune disease by controlling the activity of these self-reactive T cells. Various mechanisms are in place to achieve this control (peripheral tolerance). Activation of CD4+ T cells requires two signals; engagement of the T cell receptor (TCR) with an appropriate peptide:MHC complex (signal 1), and the aggregate effect of multiple signals generated following ligation of costi

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Lin, Kim-fung. "Evaluation of calcium/calmodulin kinase II as therapeutic target in beta-amyloid peptide neurotoxicity." Thesis, Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B3145253X.

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17

Aldughaim, Mohammed. "The use of a novel TIMP3 peptide to specifically target therapeutic drugs to tumours." Thesis, University of Sheffield, 2017. http://etheses.whiterose.ac.uk/19957/.

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18

Zhu, Maximillian. "Computational studies of the Alzheimer's amyloid-β peptide : from structural ensembles to therapeutic leads". Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608056.

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19

Yuan, Tifei, and 袁逖飞. "Self-assembling peptide nanofiber scaffold treatment to acutely injured olfactory bulb." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43816277.

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20

Grönwall, Caroline. "Affibody molecules for proteomic and therapeutic applications." Doctoral thesis, KTH, Molekylär Bioteknologi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4674.

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This thesis describes generation and characterization of Affibody molecules with future applications in proteomics research, protein structure determinations, therapeutic treatment of disease and medical imaging for in vivo diagnostics. Affibody molecules are engineered affinity proteins developed by combinatorial protein engineering from the 58-residue protein A-derived Z domain scaffold. Novel Affibody molecules targeting human proteins were selected from a combinatorial library using phage display technology. In the first two investigations, an Affibody molecule specifically targeting the h

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þráinsdóttir, Inga S. "Glucose abnormalities and heart failure : epidemiological and therapeutic aspects /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-389-2/.

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22

Askar, Basim Ali. "The therapeutic potential of vasoactive intestinal peptide (VIP) in the treatment of Gram-negative sepsis." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/32887/.

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Gram-negative bacteria are the most common cause of the sepsis and lipopolysaccharide (LPS) a major component of Gram-negative bacteria is known to be of major importance in the development of sepsis. Human infection with Salmonella, a Gram-negative bacterium, is associated with a number of cases of sepsis and is particularly important in childhood sepsis. During salmonellosis, monocytes and macrophages produce a number of different pro-inflammatory mediators such as TNF-α, IL-1α, IL-12, IL-18, IFN-γ, reactive nitrogen species and oxygen species. Although the production of these inflammatory m

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23

Allen, Stephanie D. "Therapeutic peptidomimetic strategies for costimulation blockade in multiple sclerosis and transplantation / conformational peptide vaccines of the HER-2/neu dimerization loop are effective in inhibiting mammary tumor growth in vivo." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1150479940.

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24

Tshanga, Siphokazi Sisanda. "Antibacterial activity of liposome encapsulated cyclo(TYR-PRO)." Thesis, Nelson Mandela Metropolitan University, 2011. http://hdl.handle.net/10948/1450.

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Cyclic dipeptides (CDPs) are amino acid-based compounds, some of which possess antibacterial activity. The encapsulation of certain drugs into liposomes has been found to improve their activity in terms of bioavailability and duration of action. Liposomes are small vesicles that are under investigation as drug carriers for the delivery of therapeutic agents. A number of liposome formulations are currently under clinical trial review, whilst some have already been approved for clinical use. The aim of this study was to optimize a liposomal cyclo(Tyr-Pro) formulation and to assess its antibacter

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25

Gawri, Rahul. "Link-N Peptide: a potential therapeutic agent for biological repair of early degenerated human intervertebral discs." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=121429.

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Chronic low back pain is a disease affecting a big portion of the population with 70% having at least one episode of low back during their lives. Intervertebral disc (IVD) degeneration is the most common cause of low back pain. It is associated with degradation and loss of proteoglycans, mainly aggrecan. Currently main treatment modalities offered for treating IVD degeneration are surgical and mainly target end stage disc disease. Medical therapies are being developed to treat and retard IVD degeneration and growth factor therapy is one such upcoming modality. Link protein is a component of IV

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Sharma, Arpeeta. "Therapeutic use of a mutant Caveolin-1 peptide to reduce atherosclerosis induced by hypercholesterolemia and diabetes." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/51549.

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Endothelial dysfunction is a well-established response to cardiovascular risk factors, such as hypercholesterolemia and diabetes, and is the critical first step of atherogenesis. Nitric oxide (NO), the key regulator of endothelial function, is greatly diminished in atherosclerotic disease settings resulting in augmented oxidative stress and endothelial activation, a process that involves upregulation of endothelial adhesion molecules and increased leukocyte-endothelial interactions, all of which are major steps in the pathogenesis of atherosclerosis. Pharmacological inhibition of endothelial n

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27

Lai, Sau-wan, and 賴秀芸. "Investigating beta-amyloid peptide neurotoxicity from neuronal apoptosis to endoplasmic reticulum collapse: translational research back to basic science research." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B41633702.

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28

Droctove, Laura. "Premières toxines Kunitz antagonistes du récepteur de type 2 à la vasopressine : étude pharmacodynamique et relations structure-activité." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS009/document.

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La mambaquarétine-1 (MQ-1), une toxine du mamba vert, est le tout premier peptide Kunitz à bloquer sélectivement l’activité du récepteur de type 2 à la vasopressine (V2R). Celui-ci contrôle la concentration finale des urines dans le rein. Impliqué dans plusieurs pathologies, son inhibition est actuellement considérée comme la meilleure stratégie thérapeutique dans le traitement de la polykystose rénale, une maladie génétique héréditaire. L’étude pharmacodynamique de MQ-1 sur des rats sains a confirmé son activité in vivo qui se traduit par un effet aquarétique dépendant de la dose. L’effet max

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29

Kao, Daniel Joseph. "Development of a synthetic peptide vaccine and antibody therapeutic for the prevention and treatment of Pseudomonas Aeruginosa infection /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2007.

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Thesis (Ph.D. in Pharmacology) -- University of Colorado Denver, 2007.<br>Typescript. Includes bibliographical references (leaves 203-212; 260-261). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;

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30

Cozens, Daniel. "The role of tetraspanins in bacterial adhesion to human cells and the therapeutic potential of their peptide fragments." Thesis, University of Sheffield, 2015. http://etheses.whiterose.ac.uk/13256/.

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Tetraspanins are a superfamily of eukaryotic membrane-bound proteins involved in a wide array of cellular processes, such as adhesion and migration. They do this by forming large extended networks on the surface of the cell, known as tetraspanin-enriched microdomains (TEMs), whereby they can act as membrane organisers to partner proteins, including integrins and components of the immune system. This ensures these proteins are in conformations that aid in their function. Many of these partner proteins are also the receptors to which bacteria can adhere, using adhesins. TEMs may cluster these re

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31

Arribat, Yoan. "Caractérisation de P42, région cruciale pour la fonction de la Huntingtine et peptide capable d’inhiber la toxicité associée à la Chorée de Huntington." Thesis, Montpellier 2, 2012. http://www.theses.fr/2012MON20140.

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La Maladie de Huntington (MH) reste à ce jour une pathologie neurodégénérative dévastatrice pour laquelle aucun traitement n'est disponible. L'agrégation de la Huntingtine Mutante (Htt PolyQ) joue un rôle majeur dans les processus pathologiques. Dans ce contexte, des études récentes ont démontré que la partie N-terminale de la Huntingtine Humaine (Htt wt) ou de son Homologue drosophile (dHtt) sont toutes deux capables de réduire l'agrégation et la toxicité de Htt PolyQ. En se basant sur cette observation, le travail de thèse décrit dans ce manuscrit a mis au point un découpage du fragment N-te

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32

Lemkul, Justin Alan. "Molecular Modeling of the Amyloid β-Peptide: Understanding the Mechanism of Alzheimer's Disease and the Potential for Therapeutic Intervention". Diss., Virginia Tech, 2012. http://hdl.handle.net/10919/77318.

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Alzheimer's disease is the leading cause of senile dementia in the elderly, and as life expectancy increases across the globe, incidence of the disease is continually increasing. Current estimates place the number of cases at 25-30 million worldwide, with more than 5.4 million of these occurring in the United States. While the exact cause of the disease remains a mystery, it has become clear that the amyloid β-peptide (Aβ) is central to disease pathogenesis. The aggregation and deposition of this peptide in the brain is known to give rise to the hallmark lesions associated with Alzheimer's dis

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33

Yang, Xiaotong, and 楊曉彤. "The anticancer mechanisms of polysaccharide peptide (PSP) derived fromthe Chinese medicinal fungus coriolus versicolor." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31246229.

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34

Xie, Haiyan. "The inhibitory activities of constituents of the three main categorites in ginkgo biloba towards amyloidi-ß peptide aggregation." HKBU Institutional Repository, 2014. https://repository.hkbu.edu.hk/etd_oa/68.

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The standard extract of Ginkgo biloba leaves (EGb761) is being clinically used in Europe for the treatment of impaired cerebral function in primary degenerative disorders such as Alzheimer disease (AD) and vascular dementia. The abnormal production and aggregation of amyloid β peptide (Aβ) and the deposition of fibrils in the brain is considered as key steps in the onset of AD. For this reason, the inhibition of Aβ aggregation and the destabilization of preformed fibrils have been identified as effective approaches for the prevention and treatment of AD. EGb761 mainly contains three categories

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35

Edwards, Danielle Nichele. "INTEGRIN α5β1 AS A NOVEL TARGET WITH THE SMALL PEPTIDE, ATN-161, IN THE TREATMENT OF ISCHEMIC STROKE". UKnowledge, 2019. https://uknowledge.uky.edu/neurobio_etds/21.

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Stroke is the 5th leading cause of death and the leading cause of disability in the United States, but there are only two available therapies, tissue plasminogen activator and endovascular thrombectomy. As both therapies focus on removal of the clot, the subsequent pathologic processes, i.e. inflammation, cerebrovascular breakdown, ATP depletion, etc. are left untreated, contributing to worsened patient outcome. Many clinical trials have unsuccessfully attempted to address these mechanisms. The blood-brain barrier (BBB), a system of non-fenestrated endothelial cells, extracellular matrix, and

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Faivre, Emilie. "The role of glucose-dependent insulinotropic peptide signalling in the normal brain and therapeutic effects in an Alzheimer's disease mouse model." Thesis, University of Ulster, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.588493.

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Alzheimer's disease (AD) is a neurodegenerative disease, characterized by cognitive impairments and occurrence of neuronal depositions of amyloid plaques. At present, no treatment for AD is known. A disturbance in insulin signaling and its receptor was recently highlighted in the brain of AD patients. In this study, the effect of glucose- dependent insulinotropic peptide (GIP) was investigated in the brain, as it is a potential candidate to activate a parallel signaling pathway to insulin. The lack of GIP receptor affects learning and memory in object recognition and Morris water maze tasks, s

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Shukeir, Nicholas. "Molecular mechanism(s) of prostate cancer progression : potential of therapeutic modalities." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=115853.

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Prostate cancer remains one of the most commonly diagnosed cancers in men and is a leading cause of cancer death. While great success has been achieved at curing early stage prostate cancer, limited success has been obtained when treating late-stage hormone independent prostate cancer. This is due to the increased propensity for skeletal and non-skeletal metastases. Thus development of novel effective therapeutic modalities against late stage prostate cancer is of critical importance.<br>Towards these objectives, I have focused my attention on the role of prostate secretory protein (PSP-94) wh

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Tam, Joseph. "Effect of Islet Neogenesis Associated Protein (INGAP) peptide on axonal regrowth in the peripheral sensory nervous system and its therapeutic implications for diabetic peripheral neuropathy." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103186.

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The majority of individuals with .long-term diabetes become afflicted with diabetic peripheral neuropathy (DPN), an often painful and debilitating secondary complication of the disease. Symptomatic treatments, which do not address the underlying nerve damage in diabetes, are currently the only therapeutic options for DPN, aside from rigorous control of blood glucose, which only occasionally reduces the incidence and severity of DPN. Given the progressive nature of disorder, and the failure of the classical neurotrophins in clinical trials for DPN, it is important to develop new therapeutics th

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Rossetto, Nicolas. "Optimisation de l'effet radiobiologique d'un traitement de radiothérapie interne vectorisée des tumeurs neuroendocrines." Thesis, Toulouse 3, 2017. http://www.theses.fr/2017TOU30223.

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Les médicaments radiopharmaceutiques ciblant les récepteurs peptidiques tels que les analogues de la somatostatine ont un réel potentiel et un fort intérêt pour à la fois le diagnostic et le traitement des tumeurs neuroendocrines (TNE) non-opérables, par radiothérapie interne vectorisée (RIV). La toxicité des traitements par radiopeptides analogues de la somatostatine limite leur développement clinique. Le développement de nouveaux peptides ciblant d'autres types de récepteurs tels que le ceux de la cholécystokinine (CCK) est une solution dont l'intérêt a été montré par les travaux de notre éq

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Santos, Tânia Raquel Martins dos. "Novel therapeutic strategies for the management of diabetic foot infections : the evaluation of selected antimicrobial peptides against clinically isolated bacterial pathogens." Doctoral thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2020. http://hdl.handle.net/10400.5/20150.

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Tese de Doutoramento em Ciências Veterinárias na Especialidade de Ciências Biológicas e Biomédicas<br>Diabetic foot infections (DFIs) are a frequent complication of Diabetes mellitus. These ulcers are prone to be colonized by Staphylococcus aureus and Pseudomonas aeruginosa, including multidrug resistant and biofilm-producing strains, possibly leading to DFI chronicity and amputation. New therapeutic strategies for DFI management are urgent and the antimicrobial peptides (AMPs) nisin and pexiganan are potential candidates. This project aimed to evaluate the activity of these AMPs, incorporated

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Gibson, Meghan E. "Examining the Role of Magnesium Ions in the Structural Stability of Ribosomal Subunits and An Investigation of a Novel Anticancer Therapeutic: Analyzing the Binding Affinity of a Stapled p53 Peptide Analog for Regulator MDM2." Thesis, Boston College, 2011. http://hdl.handle.net/2345/bc-ir:104431.

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Thesis advisor: Udayan Mohanty<br>Computational research can play a crucial component in the discovery of unique biochemical phenomena, from answering fundamental questions about molecular function and structure to the modeling of designed pharmaceuticals to cure many debilitating illnesses. Here computational methods are employed to examine the exquisite role that magnesium ions play in stabilizing ribosomal subunits responsible for protein translation and to analyze the potential of a proposed anticancer drug for a pathway that is impaired in the majority of human cancer cases<br>Thesis (BS)

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Ungurs, Michael J. "Molecular recognition of peptides : basis for design and delivery of peptide therapeutics." Thesis, Bangor University, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409465.

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Lopez, Aguilar Aime. "Peptides as therapeutics." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:d893e962-5cb9-4d50-bbe1-c5183418295c.

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Peptides have attracted increasing attention as therapeutics in recent years, at least partially as a consequence of the widespread acceptance of protein therapeutics; but also as possible solutions to problems such as short half-life and delivery of molecules, and as therapeutics in their own right. The current work presents three projects that involve applications of peptides in a therapeutic environment. The first project studies the use of ER retaining peptides and CPPs (Cell penetrating peptides) in enhancing the effective concentration of DNJ (1-deoxynojirimycin), an α-glucosidase inhibi

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Maherzi-Mechalikh, Chahrazed. "Optimisation des vaccins thérapeutiques induisant des réponses T CD8+ spécifiques d’antigènes tumoraux : étude de l’induction des lymphocytes T régulateurs après vaccination." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCB035.

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La détection de lymphocytes T (LT) CD8+ infiltrant les tumeurs (TIL), est généralement associée à un bon pronostic chez des patients atteints du cancer. A l’inverse, l'infiltration des tumeurs par des LT CD4+ régulateurs (Treg), est quant à elle, souvent corrélée à un mauvais pronostic. Plusieurs vaccins « thérapeutiques » capables d’induire des réponses T CD8+ spécifiques d’antigènes tumoraux ont été développés. Cependant, à ce jour, les résultats cliniques obtenus par ces vaccins restent décevants. Dans un premier travail, nous avons développé puis testé un vaccin thérapeutique composé de tr

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Gamper, Coralie. "Nanoparticules dérivées de virus de plante pour le traitement et l'imagerie du cancer." Thesis, Strasbourg, 2019. http://www.theses.fr/2019STRAJ038/document.

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Les possibilités de combinaison thérapeutiques offertes par les nanoparticules ont ouvert un nouveau champ d’investigation pour la recherche sur le cancer. Dans ce projet de recherche, des nanoparticules dérivées de la protéine de capside du virus de la mosaïque du tabac (TMV) ont été utilisées afin de transporter différents peptides thérapeutiques ciblant le récepteur neuropiline-1. Cette stratégie a permis de solubiliser un peptide fortement hydrophobe ayant préalablement démontré son efficacité anticancéreuse sur des lignées de cancer du sein humain et de glioblastome. Les résultats obtenus

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Jacob, Laurent. "Propriétés anti-angiogéniques et anti-migratoires de peptides transmembranaires ciblant le complexe neuropiline-1/plexine-A1 dans le glioblastome." Thesis, Strasbourg, 2013. http://www.theses.fr/2013STRAJ064/document.

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Ce travail poursuit l’exploration du potentiel thérapeutique de peptides antagonistes des domaines transmembranaires (TM) de récepteurs impliqués dans la croissance tumorale. J’ai montré l’effet anti-angiogénique de MTP-NRP1, un peptide ciblant le récepteur Neuropline-1 et confirmé sa capacité d’inhibition de prolifération, migration et de croissance d’une lignée de glioblastome (GBM) humain. J’ai ensuite démontré que le récepteur Plexine-A1 est corrélé à l’agressivité des gliomes et semble être un marqueur pronostique négatif de la survie des patients atteints de GBM. J’ai démontré le rôle du

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Seisel, Quentin. "Développement et vectorisation de peptides inhibiteurs du domaine PDZ de CAL pour le traitement de la mucoviscidose." Thesis, Montpellier, 2018. http://www.theses.fr/2018MONTT010/document.

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La mucoviscidose est une maladie génétique létale induite par des mutations du canal ionique CFTR, provoquant une perte de sa fonctionnalité au niveau des tissus épithéliaux de divers organes. Le poumon est particulièrement touché et devient sujet à des infections bactériennes chroniques. Dans le but de traiter la maladie, nous avons développé des « stabilisateurs » de la protéine CFTR : il s’agit de peptides inhibant l’interaction de la protéine CFTR avec le médiateur-clé de sa demi-vie à la membrane apicale des cellules épithéliales, la protéine CAL. En particulier, le peptide iCAL36 a démon

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Sattler, Maya R. "Developing Synthetic Peptide-Based Inhibitors of Human Growth Hormone Receptor." Ohio University Honors Tutorial College / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1524838355466962.

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Heal, Jonathan Richard. "Antisense peptides as potential therapeutic agents." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367576.

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Scotti, F. "Novel potential peptide therapeutics for tuberculosis therapy." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1544707/.

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Despite the existence of vaccinations, diagnostic tools and treatments, tuberculosis (TB) prevalence is increasing because of the circulation of people and misuse of antibiotics, giving rise to growing numbers of drug resistant strains of Mycobacterium tuberculosis. There is therefore a pressing need to look for new strategies against TB, in the hope of finding new drugs with novel mechanisms of anti-tubercular action or ways to potentiate the activity of already existing drugs and reduce treatment duration. This thesis explores the employment of peptides in anti-tuberculosis therapy. The proj

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