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Journal articles on the topic 'Therapeutic peptide'

Author: Grafiati

Published: 4 June 2021

Last updated: 16 February 2022

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1

Preet, Payal. "PEPTIDES: A NEW THERAPEUTIC APPROACH." International Journal of Current Pharmaceutical Research 10, no. 2 (2018): 29. http://dx.doi.org/10.22159/ijcpr.2018v10i2.25887.

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Peptide therapeutics have played a notable role in medical practice since the advent of insulin therapy in the 1920s. Over 60 peptide drugs are approved in the United States and other major markets, and peptides continue to enter clinical development at a steady pace. Peptide drug discovery has diversified beyond its traditional focus on endogenous human peptides to include a broader range of structures identified from other natural sources or through medicinal chemistry efforts. Peptides are recognized for being highly selective and efficacious and, at the same time, relatively safe and well

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Fujita, Motomichi, Manabu Sasada, Takuya Iyoda, Satoshi Osada, Hiroaki Kodama, and Fumio Fukai. "Biofunctional Peptide FNIII14: Therapeutic Potential." Encyclopedia 1, no. 2 (2021): 350–59. http://dx.doi.org/10.3390/encyclopedia1020029.

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Biofunctional peptide FNIII14, which is derived from the 14th fibronectin (FN) type III-like (FN-III) repeat of FN molecule, is capable of inhibiting cell adhesion to the extracellular matrix (ECM). This functional site is usually buried within the molecular structure of FN, but can be exposed by conformational changes and proteolytic cleavage. Peptide FNIII14 can induce a conformational change in β1-integrin from the active to the inactive form, causing functional inactivation. Based on this anti-adhesive activity, peptide FNIII14 exhibits therapeutic potential for several diseases such as me

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Zhang, Yu P., and Quan Zou. "PPTPP: a novel therapeutic peptide prediction method using physicochemical property encoding and adaptive feature representation learning." Bioinformatics 36, no. 13 (2020): 3982–87. http://dx.doi.org/10.1093/bioinformatics/btaa275.

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Abstract Motivation Peptide is a promising candidate for therapeutic and diagnostic development due to its great physiological versatility and structural simplicity. Thus, identifying therapeutic peptides and investigating their properties are fundamentally important. As an inexpensive and fast approach, machine learning-based predictors have shown their strength in therapeutic peptide identification due to excellences in massive data processing. To date, no reported therapeutic peptide predictor can perform high-quality generic prediction and informative physicochemical properties (IPPs) iden

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Karwal, Preeti, Ishwar Dutt Vats, Niharika Sinha, Anchal Singhal, Teena Sehgal, and Pratibha Kumari. "Therapeutic Applications of Peptides against Zika Virus: A Review." Current Medicinal Chemistry 27, no. 23 (2020): 3906–23. http://dx.doi.org/10.2174/0929867326666190111115132.

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Zika Virus (ZIKV) belongs to the class of flavivirus that can be transmitted by Aedes mosquitoes. The number of Zika virus caused cases of acute infections, neurological disorders and congenital microcephaly are rapidly growing and therefore, in 2016, the World Health Organization declared a global “Public Health Emergency of International Concern”. Anti-ZIKV therapeutic and vaccine development strategies are growing worldwide in recent years, however, no specific and safe treatment is available till date to save the human life. Currently, development of peptide therapeutics against ZIKV has a

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Brockhoff, Warnholtz, and Münzel. "Atrial natriuretic peptides – diagnostic and therapeutic potential." Therapeutische Umschau 57, no. 5 (2000): 305–12. http://dx.doi.org/10.1024/0040-5930.57.5.305.

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Die Familie der natriuretischen Peptide besteht aus insgesamt drei Peptiden, die große Übereinstimmung in Bezug auf die Aminosäuresequenzen und eine Schleife in ihrer Struktur besitzen. Das Atriale Natriuretische Peptid (ANP) und das Brain Natriuretische Peptid (BNP) wirken diuretisch, natriuretisch und vasodilatierend und besitzen wichtige antagonisierende Wirkungen in Bezug auf das Renin-Angiotensin-System. Das CNP hingegen ist weit weniger gut charakterisiert und besitzt im Gegensatz zu ANP und BNP nur vasodilatierende und keine diuretischen Eigenschaften. Die Plasmaspiegel von ANP und BNP

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Oyston, P. C. F., M. A. Fox, S. J. Richards, and G. C. Clark. "Novel peptide therapeutics for treatment of infections." Journal of Medical Microbiology 58, no. 8 (2009): 977–87. http://dx.doi.org/10.1099/jmm.0.011122-0.

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As antibiotic resistance increases worldwide, there is an increasing pressure to develop novel classes of antimicrobial compounds to fight infectious disease. Peptide therapeutics represent a novel class of therapeutic agents. Some, such as cationic antimicrobial peptides and peptidoglycan recognition proteins, have been identified from studies of innate immune effector mechanisms, while others are completely novel compounds generated in biological systems. Currently, only selected cationic antimicrobial peptides have been licensed, and only for topical applications. However, research using ne

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7

Smith, Josiah D., Leah N. Cardwell, David Porciani, et al. "Therapeutic peptide delivery via aptamer-displaying, disulfide-linked peptide amphiphile micelles." Molecular Systems Design & Engineering 5, no. 1 (2020): 269–83. http://dx.doi.org/10.1039/c9me00092e.

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8

Schwardt, Oliver, Christina Lamers, Clément Bechtler, and Daniel Ricklin. "Therapeutic Peptides as Emerging Options to Restore Misguided Host Defence and Homeostasis: From Teaching to Concept to Clinic." CHIMIA International Journal for Chemistry 75, no. 6 (2021): 495–99. http://dx.doi.org/10.2533/chimia.2021.495.

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Among the many molecular entities suitable for therapeutic use, peptides have emerged as a particularly attractive option for academic drug discovery and development. Their modular structure and extendibility, the availability of powerful and affordable screening platforms, and the relative ease-of-synthesis render therapeutic peptides highly approachable for teaching and research alike. With a strong focus on the therapeutic modulation of host defence pathways, including the complement and renin-angiotensin systems, the Molecular Pharmacy group at the University of Basel strongly relies on pe

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Parthasarathy, Anutthaman, Sasikala K. Anandamma, and Karunakaran A. Kalesh. "The Medicinal Chemistry of Therapeutic Peptides: Recent Developments in Synthesis and Design Optimizations." Current Medicinal Chemistry 26, no. 13 (2019): 2330–55. http://dx.doi.org/10.2174/0929867324666171012103559.

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Peptide therapeutics has made tremendous progress in the past decade. Many of the inherent weaknesses of peptides which hampered their development as therapeutics are now more or less effectively tackled with recent scientific and technological advancements in integrated drug discovery settings. These include recent developments in synthetic organic chemistry, high-throughput recombinant production strategies, highresolution analytical methods, high-throughput screening options, ingenious drug delivery strategies and novel formulation preparations. Here, we will briefly describe the key method

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Gopinatth, Varun, Rufa L. Mendez, Elaine Ballinger, and Jung Yeon Kwon. "Therapeutic Potential of Tuna Backbone Peptide and Its Analogs: An In Vitro and In Silico Study." Molecules 26, no. 7 (2021): 2064. http://dx.doi.org/10.3390/molecules26072064.

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Tuna backbone peptide (TBP) has been reported to exert potent inhibitory activity against lipid peroxidation in vitro. Since this bears relevant physiological implications, this study was undertaken to assess the impact of peptide modifications on its bioactivity and other therapeutic potential using in vitro and in silico approach. Some TBP analogs, despite lower purity than the parent peptide, exerted promising antioxidant activities in vitro demonstrated by ABTS radical scavenging assay and cellular antioxidant activity assay. In silico digestion of the peptides resulted in the generation o

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Wei, Leyi, Chen Zhou, Ran Su, and Quan Zou. "PEPred-Suite: improved and robust prediction of therapeutic peptides using adaptive feature representation learning." Bioinformatics 35, no. 21 (2019): 4272–80. http://dx.doi.org/10.1093/bioinformatics/btz246.

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Abstract Motivation Prediction of therapeutic peptides is critical for the discovery of novel and efficient peptide-based therapeutics. Computational methods, especially machine learning based methods, have been developed for addressing this need. However, most of existing methods are peptide-specific; currently, there is no generic predictor for multiple peptide types. Moreover, it is still challenging to extract informative feature representations from the perspective of primary sequences. Results In this study, we have developed PEPred-Suite, a bioinformatics tool for the generic prediction

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Mäde, Veronika, Sylvia Els-Heindl, and Annette G. Beck-Sickinger. "Automated solid-phase peptide synthesis to obtain therapeutic peptides." Beilstein Journal of Organic Chemistry 10 (May 22, 2014): 1197–212. http://dx.doi.org/10.3762/bjoc.10.118.

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The great versatility and the inherent high affinities of peptides for their respective targets have led to tremendous progress for therapeutic applications in the last years. In order to increase the drugability of these frequently unstable and rapidly cleared molecules, chemical modifications are of great interest. Automated solid-phase peptide synthesis (SPPS) offers a suitable technology to produce chemically engineered peptides. This review concentrates on the application of SPPS by Fmoc/t-Bu protecting-group strategy, which is most commonly used. Critical issues and suggestions for the s

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Kristensen, M., C. Foged, J. Berthelsen, and H. Mørck Nielsen. "Peptide-enhanced oral delivery of therapeutic peptides and proteins." Journal of Drug Delivery Science and Technology 23, no. 4 (2013): 365–73. http://dx.doi.org/10.1016/s1773-2247(13)50053-0.

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14

Bak, Mijeong, Junyong Park, Kiyoon Min, et al. "Recombinant Peptide Production Platform Coupled with Site-Specific Albumin Conjugation Enables a Convenient Production of Long-Acting Therapeutic Peptide." Pharmaceutics 12, no. 4 (2020): 364. http://dx.doi.org/10.3390/pharmaceutics12040364.

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The number of therapeutic peptides for human treatment is growing rapidly. However, their development faces two major issues: the poor yield of large peptides from conventional solid-phase synthesis, and the intrinsically short serum half-life of peptides. To address these issues, we investigated a platform for the production of a recombinant therapeutic peptide with an extended serum half-life involving the site-specific conjugation of human serum albumin (HSA). HSA has an exceptionally long serum half-life and can be used to extend the serum half-lives of therapeutic proteins and peptides. W

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15

Zhang, Xian-Yang, Lisa To, Jakob Reiser, Charles S. Hemenway, Michel W. Sadelain, and Vincent F. La Russa. "Strategies for Therapeutic Peptide Delivery by Mesenchymal Stem Cells." Blood 112, no. 11 (2008): 863. http://dx.doi.org/10.1182/blood.v112.11.863.863.

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Abstract More than 50% of infants with ALL have leukemic blast cells that contain MLL fusion genes with reciprocal translocation t(4;11)(q21;q23). We have shown that AF4 and AF9 form a stable protein complex in the nucleus and that the mutual interaction domains of the two proteins are present within MLL fusion proteins (Erfurth et al., 2004). Mapping of the protein interaction domains reveals that a small, highly conserved portion of the AF4 molecule is necessary and sufficient to bind AF9. To test the significance of the AF4-AF9 protein interaction, we developed small synthetic peptides capa

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Zhang, Yuqi, and Michel F. Sanner. "AutoDock CrankPep: combining folding and docking to predict protein–peptide complexes." Bioinformatics 35, no. 24 (2019): 5121–27. http://dx.doi.org/10.1093/bioinformatics/btz459.

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Abstract Motivation Protein–peptide interactions mediate a wide variety of cellular and biological functions. Methods for predicting these interactions have garnered a lot of interest over the past few years, as witnessed by the rapidly growing number of peptide-based therapeutic molecules currently in clinical trials. The size and flexibility of peptides has shown to be challenging for existing automated docking software programs. Results Here we present AutoDock CrankPep or ADCP in short, a novel approach to dock flexible peptides into rigid receptors. ADCP folds a peptide in the potential f

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Li, Wenyi, John D. Wade, Eric Reynolds, and Neil M. O'Brien-Simpson. "Chemical Modification of Cellulose Membranes for SPOT Synthesis." Australian Journal of Chemistry 73, no. 3 (2020): 78. http://dx.doi.org/10.1071/ch19335.

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Since the development of solid-phase peptide synthesis in the 1960s, many laboratories have modified the technology for the production of peptide arrays to facilitate the discovery of novel peptide mimetics and therapeutics. One of these, known as SPOT synthesis, enables parallel peptide synthesis on cellulose paper sheets and has several advantages over other peptide arrays methods. Today, the SPOT technique remains one of the most frequently used methods for synthesis and screening of peptides on arrays. Although polypropylene and glass can be used for the preparation of peptide arrays, the

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de Coupade, Catherine, Antonio Fittipaldi, Vanessa Chagnas, et al. "Novel human-derived cell-penetrating peptides for specific subcellular delivery of therapeutic biomolecules." Biochemical Journal 390, no. 2 (2005): 407–18. http://dx.doi.org/10.1042/bj20050401.

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Short peptide sequences that are able to transport molecules across the cell membrane have been developed as tools for intracellular delivery of therapeutic molecules. This work describes a novel family of cell-penetrating peptides named Vectocell® peptides [also termed DPVs (Diatos peptide vectors)]. These peptides, originating from human heparin binding proteins and/or anti-DNA antibodies, once conjugated to a therapeutic molecule, can deliver the molecule to either the cytoplasm or the nucleus of mammalian cells. Vectocell® peptides can drive intracellular delivery of molecules of varying m

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Chan, Lai Y., Sunithi Gunasekera, Sonia T. Henriques, et al. "Engineering pro-angiogenic peptides using stable, disulfide-rich cyclic scaffolds." Blood 118, no. 25 (2011): 6709–17. http://dx.doi.org/10.1182/blood-2011-06-359141.

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Abstract Fragments from the extracellular matrix proteins laminin and osteopontin and a sequence from VEGF have potent proangiogenic activity despite their small size (< 10 residues). However, these linear peptides have limited potential as drug candidates for therapeutic angiogenesis because of their poor stability. In the present study, we show that the therapeutic potential of these peptides can be significantly improved by “grafting” them into cyclic peptide scaffolds. Momordica cochinchinensis trypsin inhibitor-II (MCoTI-II) and sunflower trypsin inhibitor-1 (SFTI-1), naturally occurri

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Smolarczyk, Ryszard, Tomasz Cichoń, Klaudyna Graja, Joanna Hucz, Aleksander Sochanik, and Stanisław Szala. "Antitumor effect of RGD-4C-GG-D(KLAKLAK)2 peptide in mouse B16(F10) melanoma model." Acta Biochimica Polonica 53, no. 4 (2006): 801–5. http://dx.doi.org/10.18388/abp.2006_3309.

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Vasculature targeting agents have been tested as cancer therapeutics for the past few years. Such therapy could be accomplished using, for example, bifunctional (two-domain) peptides. RGD-4C-GG-D(KLAKLAK)2, a peptide designed by Ellerby and coworkers (1999) (full sequence: ACDCRGDCFCGGKLAKLAKKLAKLAK), binds selectively to alphaVbeta3 integrin receptors expressed in tumor neovasculature and, after internalization, effectively induces apoptosis of endothelial cells. The aim of this study was to examine if RGD-4C-GG-D(KLAKLAK)2 would efficiently target cells, among them B16(F10), that overexpress

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Park, Dongkook, Xiaowen Hou, Jonathan V. Sweedler, and Paul H. Taghert. "Therapeutic peptide production in Drosophila." Peptides 36, no. 2 (2012): 251–56. http://dx.doi.org/10.1016/j.peptides.2012.05.003.

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22

Nielsen, Carsten Uhd, Birger Brodin, Flemming Steen Jørgensen, Sven Frokjaer, and Bente Steffansen. "Human peptide transporters: therapeutic applications." Expert Opinion on Therapeutic Patents 12, no. 9 (2002): 1329–50. http://dx.doi.org/10.1517/13543776.12.9.1329.

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Jia, Boyan, Yiming Wang, Ying Zhang, et al. "High Cell Selectivity and Bactericidal Mechanism of Symmetric Peptides Centered on d-Pro–Gly Pairs." International Journal of Molecular Sciences 21, no. 3 (2020): 1140. http://dx.doi.org/10.3390/ijms21031140.

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Antimicrobial peptides (AMPs) have a unique action mechanism that can help to solve global problems in antibiotic resistance. However, their low therapeutic index and poor stability seriously hamper their development as therapeutic agents. In order to overcome these problems, we designed peptides based on the sequence template XXRXXRRzzRRXXRXX-NH2, where X represents a hydrophobic amino acid like Phe (F), Ile (I), and Leu (L), while zz represents Gly–Gly (GG) or d-Pro–Gly (pG). Showing effective antimicrobial activity against Gram-negative bacteria and low toxicity, designed peptides had a ten

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Palermo, Christine M., William C. Wimley, and Charles S. Hemenway. "Enhancing the Therapeutic Potential of an Anti-Leukemic Peptide." Blood 106, no. 11 (2005): 245. http://dx.doi.org/10.1182/blood.v106.11.245.245.

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Abstract Despite ongoing success in the treatment of childhood acute lymphoblastic leukemia (ALL), patients harboring translocations involving the genetic locus 11q23 continue to have a poor prognosis. The majority of 11q23 translocations result in the formation of a functional fusion protein consisting of the N-terminus of MLL fused to the C-terminal portion of one of more than 30 fusion partners. This translocation results in a functional chimeric protein critical for leukemogenesis. Recently, our lab has identified an interaction between two common MLL fusion partners, AF4 and AF9. Through

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Wu, Qihui, Hanzhong Ke, Dongli Li, Qi Wang, Jiansong Fang, and Jingwei Zhou. "Recent Progress in Machine Learning-based Prediction of Peptide Activity for Drug Discovery." Current Topics in Medicinal Chemistry 19, no. 1 (2019): 4–16. http://dx.doi.org/10.2174/1568026619666190122151634.

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Over the past decades, peptide as a therapeutic candidate has received increasing attention in drug discovery, especially for antimicrobial peptides (AMPs), anticancer peptides (ACPs) and antiinflammatory peptides (AIPs). It is considered that the peptides can regulate various complex diseases which are previously untouchable. In recent years, the critical problem of antimicrobial resistance drives the pharmaceutical industry to look for new therapeutic agents. Compared to organic small drugs, peptide- based therapy exhibits high specificity and minimal toxicity. Thus, peptides are widely recr

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Boisguérin, Prisca, Karidia Konate, Emilie Josse, Eric Vivès, and Sébastien Deshayes. "Peptide-Based Nanoparticles for Therapeutic Nucleic Acid Delivery." Biomedicines 9, no. 5 (2021): 583. http://dx.doi.org/10.3390/biomedicines9050583.

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Gene therapy offers the possibility to skip, repair, or silence faulty genes or to stimulate the immune system to fight against disease by delivering therapeutic nucleic acids (NAs) to a patient. Compared to other drugs or protein treatments, NA-based therapies have the advantage of being a more universal approach to designing therapies because of the versatility of NA design. NAs (siRNA, pDNA, or mRNA) have great potential for therapeutic applications for an immense number of indications. However, the delivery of these exogenous NAs is still challenging and requires a specific delivery system

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Wolska, Anna, Mart Reimund, Denis O. Sviridov, Marcelo J. Amar, and Alan T. Remaley. "Apolipoprotein Mimetic Peptides: Potential New Therapies for Cardiovascular Diseases." Cells 10, no. 3 (2021): 597. http://dx.doi.org/10.3390/cells10030597.

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Since the seminal breakthrough of treating diabetic patients with insulin in the 1920s, there has been great interest in developing other proteins and their peptide mimetics as therapies for a wide variety of other medical disorders. Currently, there are at least 60 different peptides that have been approved for human use and over 150 peptides that are in various stages of clinical development. Peptides mimetic of the major proteins on lipoproteins, namely apolipoproteins, have also been developed first as tools for understanding apolipoprotein structure and more recently as potential therapeu

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Khaldi, Nora. "Bioinformatics approaches for identifying new therapeutic bioactive peptides in food." Functional Foods in Health and Disease 2, no. 10 (2012): 325. http://dx.doi.org/10.31989/ffhd.v2i10.80.

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The traditional methods for mining foods for bioactive peptides are tedious and long. Similar to the drug industry, the length of time to identify and deliver a commercial health ingredient that reduces disease symptoms can take anything between 5 to 10 years. Reducing this time and effort is crucial in order to create new commercially viable products with clear and important health benefits. In the past few years, bioinformatics, the science that brings together fast computational biology, and efficient genome mining, is appearing as the long awaited solution to this problem. By quickly minin

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Hu, Zhenhua, Sara Nizzero, Shreya Goel, et al. "Molecular targeting of FATP4 transporter for oral delivery of therapeutic peptide." Science Advances 6, no. 14 (2020): eaba0145. http://dx.doi.org/10.1126/sciadv.aba0145.

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Low oral bioavailability of peptide drugs has limited their application to parenteral administration, which suffers from poor patient compliance. Here, we show that molecular targeting of the FATP4 transporter is an effective approach to specifically transport long-chain fatty acid (LCFA)–conjugated peptides across the enterocytic membrane and, thus, enables oral delivery of drug peptides. We packaged LCFA-conjugated exendin-4 (LCFA-Ex4) into liposomes and coated with chitosan nanoparticles to form an orally deliverable Ex4 (OraEx4). OraEx4 protected LCFA-Ex4 from damage by the gastric fluid a

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Abdalla, Muna, and Lyndy McGaw. "Natural Cyclic Peptides as an Attractive Modality for Therapeutics: A Mini Review." Molecules 23, no. 8 (2018): 2080. http://dx.doi.org/10.3390/molecules23082080.

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Peptides are important biomolecules which facilitate the understanding of complex biological processes, which in turn could be serendipitous biological targets for future drugs. They are classified as a unique therapeutic niche and will play an important role as fascinating agents in the pharmaceutical landscape. Until now, more than 40 cyclic peptide drugs are currently in the market, and approximately one new cyclopeptide drug enters the market annually on average. Interestingly, the majority of clinically approved cyclic peptides are derived from natural sources, such as peptide antibiotics

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Ciociola, Tecla, Thelma A. Pertinhez, Laura Giovati, et al. "Dissecting the Structure-Function Relationship of a Fungicidal Peptide Derived from the Constant Region of Human Immunoglobulins." Antimicrobial Agents and Chemotherapy 60, no. 4 (2016): 2435–42. http://dx.doi.org/10.1128/aac.01753-15.

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ABSTRACTSynthetic peptides encompassing sequences related to the complementarity-determining regions of antibodies or derived from their constant region (Fc peptides) were proven to exert differential antimicrobial, antiviral, antitumor, and/or immunomodulatory activitiesin vitroand/orin vivo, regardless of the specificity and isotype of the parental antibody. Alanine substitution derivatives of these peptides exhibited unaltered, increased, or decreased candidacidal activitiesin vitro. The bioactive IgG-derived Fc N10K peptide (NQVSLTCLVK) spontaneously self-assembles, a feature previously re

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Kasetty, Gopinath, Praveen Papareddy, Martina Kalle, et al. "Structure-Activity Studies and Therapeutic Potential of Host Defense Peptides of Human Thrombin." Antimicrobial Agents and Chemotherapy 55, no. 6 (2011): 2880–90. http://dx.doi.org/10.1128/aac.01515-10.

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ABSTRACTPeptides of the C-terminal region of human thrombin are released upon proteolysis and identified in human wounds. In this study, we wanted to investigate minimal determinants, as well as structural features, governing the antimicrobial and immunomodulating activity of this peptide region. Sequential amino acid deletions of the peptide GKYGFYTHVFRLKKWIQKVIDQFGE (GKY25), as well as substitutions at strategic and structurally relevant positions, were followed by analyses of antimicrobial activity against the Gram-negative bacteriaEscherichia coliandPseudomonas aeruginosa, the Gram-positiv

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Marsh, Spencer R., Zachary J. Williams, Kevin J. Pridham, and Robert G. Gourdie. "Peptidic Connexin43 Therapeutics in Cardiac Reparative Medicine." Journal of Cardiovascular Development and Disease 8, no. 5 (2021): 52. http://dx.doi.org/10.3390/jcdd8050052.

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Connexin (Cx43)-formed channels have been linked to cardiac arrhythmias and diseases of the heart associated with myocardial tissue loss and fibrosis. These pathologies include ischemic heart disease, ischemia-reperfusion injury, heart failure, hypertrophic cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, and Duchenne muscular dystrophy. A number of Cx43 mimetic peptides have been reported as therapeutic candidates for targeting disease processes linked to Cx43, including some that have advanced to clinical testing in humans. These peptides include Cx43 sequences based on the e

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Havasi, Andrea, Weining Lu, Herbert T. Cohen, et al. "Blocking peptides and molecular mimicry as treatment for kidney disease." American Journal of Physiology-Renal Physiology 312, no. 6 (2017): F1016—F1025. http://dx.doi.org/10.1152/ajprenal.00601.2015.

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Protein mimotopes, or blocking peptides, are small therapeutic peptides that prevent protein-protein interactions by selectively mimicking a native binding domain. Inexpensive technology facilitates straightforward design and production of blocking peptides in sufficient quantities to allow preventive and therapeutic trials in both in vitro and in vivo experimental disease models. The kidney is an ideal peptide target, since small molecules undergo rapid filtration and efficient bulk absorption by tubular epithelial cells. Because the half-life of peptides is markedly prolonged in the kidneys

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Fialho, Arsenio M., Prabhakar Salunkhe, Sunil Manna, Sidharth Mahali, and Ananda M. Chakrabarty. "Glioblastoma Multiforme: Novel Therapeutic Approaches." ISRN Neurology 2012 (February 8, 2012): 1–10. http://dx.doi.org/10.5402/2012/642345.

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The current therapy for glioblastoma multiforme involves total surgical resection followed by combination of radiation therapy and temozolomide. Unfortunately, the efficacy for such current therapy is limited, and newer approaches are sorely needed to treat this deadly disease. We have recently described the isolation of bacterial proteins and peptides with anticancer activity. In phase I human clinical trials, one such peptide, p28, derived from a bacterial protein azurin, showed partial and complete regression of tumors in several patients among 15 advanced-stage cancer patients with refract

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Jenssen, Håvard, Pamela Hamill, and Robert E. W. Hancock. "Peptide Antimicrobial Agents." Clinical Microbiology Reviews 19, no. 3 (2006): 491–511. http://dx.doi.org/10.1128/cmr.00056-05.

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SUMMARY Antimicrobial host defense peptides are produced by all complex organisms as well as some microbes and have diverse and complex antimicrobial activities. Collectively these peptides demonstrate a broad range of antiviral and antibacterial activities and modes of action, and it is important to distinguish between direct microbicidal and indirect activities against such pathogens. The structural requirements of peptides for antiviral and antibacterial activities are evaluated in light of the diverse set of primary and secondary structures described for host defense peptides. Peptides wit

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Racheva, M., O. Romero, K. K. Julich-Gruner, A. S. Ulrich, C. Wischke, and A. Lendlein. "Purity of mushroom tyrosinase as a biocatalyst for biomaterial synthesis affects the stability of therapeutic peptides." MRS Proceedings 1718 (2015): 85–90. http://dx.doi.org/10.1557/opl.2015.260.

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ABSTRACTThe formation of injectable implants in the presence of cells or solutes has previously been conceptualized to be based on the selectivity of bioorthogonal chemical reactions. As an alternative approach, hydrogel network synthesis by enzymatic reactions with a typically high inherent substrate specificity and low toxicity have been repeatedly proposed, e.g. using commercial mushroom tyrosinase (MTyr), which specifically catalyzes phenol oxidation. In this study, it should be explored whether MTyr is compatible with therapeutic peptides that may be delivered from such hydrogels in the f

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Boparai, Jaspreet Kaur, and Pushpender Kumar Sharma. "Mini Review on Antimicrobial Peptides, Sources, Mechanism and Recent Applications." Protein & Peptide Letters 27, no. 1 (2019): 4–16. http://dx.doi.org/10.2174/0929866526666190822165812.

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Antimicrobial peptides in recent years have gained increased interest among scientists, health professionals and the pharmaceutical companies owing to their therapeutic potential. These are low molecular weight proteins with broad range antimicrobial and immuno modulatory activities against infectious bacteria (Gram positive and Gram negative), viruses and fungi. Inability of micro-organisms to develop resistance against most of the antimicrobial peptide has made them as an efficient product which can greatly impact the new era of antimicrobials. In addition to this these peptides also demonst

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Moradi, Shayli Varasteh, Waleed M. Hussein, Pegah Varamini, Pavla Simerska, and Istvan Toth. "Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides." Chemical Science 7, no. 4 (2016): 2492–500. http://dx.doi.org/10.1039/c5sc04392a.

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Neelov, Igor, Valerii Bezrodnyi, Anna Marchenko, Emil Fatullaev, and Sofia Miktaniuk. "Computer simulation of complex of lysine dendrigraft with molecules of therapeutic KED peptide." ITM Web of Conferences 24 (2019): 02008. http://dx.doi.org/10.1051/itmconf/20192402008.

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Lysine dendrimers and dendrigrafts are often used in biomedicine for drug and gene delivery to different target organs or cells. In present paper the possibility of complex formation by lysine dendrigraft and 16 molecules of therapeutic KED peptide was investigated using molecular dynamics simulation method. A system containing of one dendrigraftt and 16 KED peptides in water were studied. It was shown that stable complex consisting of the dendrigraft and the peptide molecules formed and structure of this complex was studied. Similar complexes could be used in future for delivery of other ther

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Xiao, Yu-Feng, Meng-Meng Jie, Bo-Sheng Li, et al. "Peptide-Based Treatment: A Promising Cancer Therapy." Journal of Immunology Research 2015 (2015): 1–13. http://dx.doi.org/10.1155/2015/761820.

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Many new therapies are currently being used to treat cancer. Among these new methods, chemotherapy based on peptides has been of great interest due to the unique advantages of peptides, such as a low molecular weight, the ability to specifically target tumor cells, and low toxicity in normal tissues. In treating cancer, peptide-based chemotherapy can be mainly divided into three types, peptide-alone therapy, peptide vaccines, and peptide-conjugated nanomaterials. Peptide-alone therapy may specifically enhance the immune system’s response to kill tumor cells. Peptide-based vaccines have been us

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Pasut, G., A. Guiotto, and FM Veronese. "Protein, peptide and non-peptide drug PEGylation for therapeutic application." Expert Opinion on Therapeutic Patents 14, no. 6 (2004): 859–94. http://dx.doi.org/10.1517/13543776.14.6.859.

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Mustafa, Sabeena, Hanan Balkhy, and Musa Gabere. "Peptide-Protein Interaction Studies of Antimicrobial Peptides Targeting Middle East Respiratory Syndrome Coronavirus Spike Protein: An In Silico Approach." Advances in Bioinformatics 2019 (July 1, 2019): 1–16. http://dx.doi.org/10.1155/2019/6815105.

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There is no effective therapeutic or vaccine for Middle East Respiratory Syndrome and this study attempts to find therapy using peptide by establishing a basis for the peptide-protein interactions through in silico docking studies for the spike protein of MERS-CoV. The antimicrobial peptides (AMPs) were retrieved from the antimicrobial peptide database (APD3) and shortlisted based on certain important physicochemical properties. The binding mode of the shortlisted peptides was measured based on the number of clusters which forms in a protein-peptide docking using Piper. As a result, we identif

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Magen, Iddo, and Illana Gozes. "Davunetide: Peptide Therapeutic in Neurological Disorders." Current Medicinal Chemistry 21, no. 23 (2014): 2591–98. http://dx.doi.org/10.2174/0929867321666140217124945.

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Durao, Joana, and Luis Gales. "Peptide Self-Assembly for Therapeutic Applications." Current Organic Chemistry 19, no. 19 (2015): 1874–81. http://dx.doi.org/10.2174/1385272819666150608220036.

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Nielsen, Peter E. "Peptide nucleic acids as therapeutic agents." Current Opinion in Structural Biology 9, no. 3 (1999): 353–57. http://dx.doi.org/10.1016/s0959-440x(99)80047-5.

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Amiel, StephanieA. "Glucagon-like peptide: a therapeutic glimmer." Lancet 343, no. 8888 (1994): 4–5. http://dx.doi.org/10.1016/s0140-6736(94)90869-9.

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Kliger, Yossef. "Computational approaches to therapeutic peptide discovery." Biopolymers 94, no. 6 (2010): 701–10. http://dx.doi.org/10.1002/bip.21458.

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Venugopalan, C. S., and N. A. O'Malley. "Vasoactive intestinal peptide: A therapeutic agent?" Drugs of the Future 12, no. 10 (1987): 977. http://dx.doi.org/10.1358/dof.1987.012.10.105653.

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Ronspeck, Wolfgang, Roland Brinckmann, Ralf Egner, et al. "Peptide Based Adsorbers for Therapeutic Immunoadsorption." Therapeutic Apheresis and Dialysis 7, no. 1 (2003): 91–97. http://dx.doi.org/10.1046/j.1526-0968.2003.00017.x.

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