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Journal articles on the topic 'Therapeutic phlebotomy'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Cook, Lynda S. "Therapeutic Phlebotomy." Journal of Infusion Nursing 33, no. 2 (2010): 81–88. http://dx.doi.org/10.1097/nan.0b013e3181d00010.

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2

Zubair, Abba. "Therapeutic phlebotomy." Clinical Liver Disease 4, no. 5 (2014): 102–6. http://dx.doi.org/10.1002/cld.408.

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Ahmad, Dr Sharique, Dr Shriya Arora, and Dr Tanish Baqar. "Therapeutic Phlebotomy Revisited: A Review." Saudi Journal of Medicine 8, no. 04 (2023): 152–58. http://dx.doi.org/10.36348/sjm.2023.v08i04.004.

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Therapeutic phlebotomy is the removal of red blood cells or serum iron from the blood. It is one of the preferred treatments for blood disorders. In ancient times this process was known as bloodletting. Generalized method included were venesection and arteriotomy and systemic methods included were cupping and by leeches. It stimulates bone marrow stem cells to generate new red blood cells (RBCs). Iron for hemoglobin synthesis is taken from the body thus reducing serum iron. Different indications of therapeutic phlebotomy include Polycythemia Vera, Hemochromatosis, Porphyria cutanea tarda, Sick

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Wenk, R. E., and M. K. Brewer. "Simple, Nontraumatic Therapeutic Phlebotomy." Transfusion 15, no. 4 (2003): 380. http://dx.doi.org/10.1046/j.1537-2995.1975.15476034564.x.

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Newham, Benjamin JC, and Rahul Khanna. "The effect of therapeutic phlebotomy for hemochromatosis on non-suicidal self-injury: A case report." International Journal of Psychiatry in Medicine 54, no. 1 (2018): 74–79. http://dx.doi.org/10.1177/0091217418791451.

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Background Self-phlebotomy has been described as a form of non-suicidal self-injury. However, a relationship between non-suicidal self-injury and therapeutic phlebotomy for hemochromatosis has not previously been described. Case presentation: We present a case of a 52-year-old man in whom the frequency of his therapeutic phlebotomy and non-suicidal self-injury were inversely linked, leading to adverse outcomes when his phlebotomy was suspended. Conclusions This is the first report describing the relationship between non-suicidal self-injury and therapeutic phlebotomy. This case highlights the

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6

Wright, Salena M., and Jean Finical. "Beyond Leeches Therapeutic Phlebotomy Today." American Journal of Nursing 100, no. 7 (2000): 55. http://dx.doi.org/10.2307/3521760.

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Oh, Ki Young, and Kyung hee Kim. "Clinical applications of therapeutic phlebotomy." Journal of Blood Medicine Volume 7 (July 2016): 139–44. http://dx.doi.org/10.2147/jbm.s108479.

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Antle, Emily (Amy). "Who Needs a Therapeutic Phlebotomy?" Clinical Journal of Oncology Nursing 14, no. 6 (2010): 694–96. http://dx.doi.org/10.1188/10.cjon.694-696.

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9

Machhi, Rushad, Ashley M. Cunningham, Kenneth Hennrick, Karen A. Schaser, Eliot C. Williams, and William Nicholas Rose. "Unexplained Hematocrit Increase after Therapeutic Phlebotomy in a Patient with Marked Erythrocytosis." Case Reports in Hematology 2022 (August 11, 2022): 1–3. http://dx.doi.org/10.1155/2022/5018388.

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We report a patient with hereditary erythrocytosis who underwent a therapeutic phlebotomy and had a post-phlebotomy hematocrit that was higher than the pre-phlebotomy hematocrit. We could not discern a reason for this hematocrit increase after phlebotomy. Instead of performing another phlebotomy, we performed an automated red cell depletion via an apheresis instrument. This procedure is essentially a red cell exchange, but 5% albumin is used as the replacement fluid instead of red blood cells. The patient’s hematocrit decreased from 80% to 39% after three consecutive daily red cell depletion p

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Kumar, Madhan Srinivasan, Sumukh Arun Kumar, Rahul Mishra, et al. "Self-Sustainability with Therapeutic Phlebotomy, a Solution to the National Blood Crisis?" Blood 142, Supplement 1 (2023): 5051. http://dx.doi.org/10.1182/blood-2023-187612.

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CONCLUSION Hereditary hemochromatosis (HH) is a genetic condition associated with iron overload in the human body. The mainstay of treatment remains therapeutic phlebotomy. On August 1st, 2022, the American Red Cross approved using blood obtained from therapeutic phlebotomy for transfusion. While normal individuals can donate blood only as often as once in 56 days, individuals with HH can have phlebotomy as often as once weekly. Utilizing the blood collected from these patients could be a significant resource to mitigate the shortage of blood needed for transfusion. We aimed to quantify the nu

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11

Gupta, Sonal Suresh, Shweta Wasudeo Dhote, Shubhangi Lad, and Damayanti Radhashyam Dey. "A Study of Indications, Clinical Applications, and Effects of Therapeutic Phlebotomy at a Tertiary Care Hospital Navi Mumbai." Global Journal of Transfusion Medicine 9, no. 2 (2024): 126–29. http://dx.doi.org/10.4103/gjtm.gjtm_18_24.

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ABSTRACT Background and Objectives: The removal of blood from the body is known as phlebotomy, venesection, or bloodletting. Therapeutic phlebotomy is the preferred treatment for blood disorders where removing red blood cells or serum iron is the most effective way to manage symptoms and complications. In current medical practice, therapeutic phlebotomy is a clinically-supervised intervention for diseases such as polycythemia vera, hemochromatosis, porphyria cutanea tarda, nonalcoholic fatty liver disease, and sickle cell crisis. The aim of this study was to analyze the indications for therape

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Draviam, Anna, and Esther Soundar. "Anemia in Patients Undergoing Therapeutic Phlebotomy for Polycythemia Secondary to COPD and OSA." Blood 144, Supplement 1 (2024): 5607. https://doi.org/10.1182/blood-2024-210420.

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Background: Therapeutic phlebotomy is performed to relieve symptoms of secondary polycythemia in chronic hypoxic lung diseases such as chronic obstructive pulmonary disorder (COPD) and obstructive sleep apnea (OSA). Excessive phlebotomy may cause iron deficiency anemia, leading to hypoxemia and resulting in vicious cycle of further erythropoiesis and hyper viscosity. Also, anemia of chronic disease is prevalent both in COPD and OSA patients due to the underlying systemic inflammation. Our aim is to find if adult patients develop anemia while undergoing prolonged therapeutic phlebotomy treatmen

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Noreen, Nosheena, Syeda Wajeeha Jalil, Rabeea Irfan, and Farah Hanif. "Analysis of Therapeutic Phlebotomy in Patients of Polycythemia: A Single Center Study." Journal of Islamabad Medical & Dental College 12, no. 3 (2023): 199–203. http://dx.doi.org/10.35787/jimdc.v12i3.955.

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Introduction: Polycythemia is increased red cell mass according to age and sex of the individual. It could be primary (Polycythemia Vera), or secondary, due to chronic hypoxia or increased erythropoietic drive. Polycythemia is managed with therapeutic phlebotomy along with treating the underlying cause if determined. Phlebotomy of one unit whole blood should result in fall of Hb of at least 1g/dl. This study was conducted to see the effect of phlebotomy on fall in Hb level.Different parameters which can affect Hb levels in polycythemia patients, like age, JAK-2 mutation status and underlying c

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Panigrahi, Rashmita, Samarendra Satpathy, Manu Mangat Marandi, and Sabita Palai. "Impact of therapeutic phlebotomy on haematological parameters of patients and their clinical outcome." Panacea Journal of Medical Sciences 15, no. 1 (2025): 214–19. https://doi.org/10.18231/pjms.v.15.i.1.214-219.

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Background: Phlebotomy, also known as bloodletting or venesection, is a major therapeutic procedure. Currently, there are three main indications for therapeutic phlebotomy i.e., haemochromatosis, polycythaemia vera (PV) and porphyria cutanea tarda (PCT) along with sickle cell disease, some cases of secondary polycythaemia like post renal transplant patient and cyanotic heart disease and hypoxic conditions like chronic lung disease. Aims and Objective: To evaluate the effect of therapeutic phlebotomy on haematological parameters and also its role in clinical outcome. Materials and Methods: The

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Peedin, Alexis R., and Julie Katz Karp. "How do I…perform therapeutic phlebotomy?" Transfusion 61, no. 3 (2021): 673–77. http://dx.doi.org/10.1111/trf.16308.

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Van Buren, Nancy L., Anita J. Hove, Tracy A. French, and Jed B. Gorlin. "Therapeutic Phlebotomy for Testosterone-Induced Polycythemia." American Journal of Clinical Pathology 154, no. 1 (2020): 33–37. http://dx.doi.org/10.1093/ajcp/aqaa019.

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Abstract Objectives To evaluate therapeutic phlebotomy (TP) requests for testosterone replacement therapy (TRT) and to highlight the impact to a blood center (BC) or service that provides TP for individuals on TRT. Methods Review of TP requests for individuals on TRT at our BC over a 3-year period from 2014 through 2016, as well as the total number of TP collections. Results Total TPs during 2014, 2015, and 2016 were 475, 500, and 569, respectively. Annual TP collections for patients on TRT were 193, 212, and 239, respectively. TRT patients with TP orders increased 71.4% during this period. Af

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Aygun, Banu, Nicole A. Mortier, Karen Kesler, et al. "Therapeutic Phlebotomy in Children with Sickle Cell Anemia, Stroke, and Iron Overload: The SWiTCH Experience." Blood 118, no. 21 (2011): 1044. http://dx.doi.org/10.1182/blood.v118.21.1044.1044.

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Abstract Abstract 1044 Background: Stroke With Transfusions Changing to Hydroxyurea (SWiTCH Clinical Trials.gov NCT00122980), an NHLBI-sponsored Phase III multicenter trial, compared chronic blood transfusions/chelation to hydroxyurea/phlebotomy for the reduction of recurrent stroke and improvement in iron overload management in children with sickle cell anemia (SCA) and history of overt stroke. To date, however, phlebotomy to manage iron overload has not been commonly performed in children, especially those with SCA. Objective: To describe the experience with SWiTCH phlebotomy procedures, inc

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PARKER, DONNA M., PHYLLIS C. DEEL, and SANDRA S. ARNER. "IRON OUT THE DETAILS OF THERAPEUTIC PHLEBOTOMY." Nursing 34, no. 2 (2004): 46–47. http://dx.doi.org/10.1097/00152193-200402000-00046.

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Aygun, Banu, Nicole Mortier, Zora R. Rogers, et al. "Iron Unloading By Therapeutic Phlebotomy in Previously Transfused Children with Sickle Cell Anemia: The Twitch Experience." Blood 128, no. 22 (2016): 1018. http://dx.doi.org/10.1182/blood.v128.22.1018.1018.

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Abstract Background: TCD With Transfusions Changing to Hydroxyurea (TWiTCH, ClinicalTrials.gov NCT01425307), an NHLBI-sponsored Phase III multicenter trial, compared transfusions to hydroxyurea for maintaining TCD velocities in children with sickle cell anemia who previously received transfusions for abnormal TCD velocities. Iron overload was treated with serial phlebotomy in children randomized to hydroxyurea. At the first scheduled interim analysis, non-inferiority of hydroxyurea was demonstrated and the study was terminated prematurely. Methods: Participants randomized to hydroxyurea receiv

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Casu, Carla, Alison Liu, Gianluca De Rosa, et al. "Tmprss6-ASO as a tool for the treatment of Polycythemia Vera mice." PLOS ONE 16, no. 12 (2021): e0251995. http://dx.doi.org/10.1371/journal.pone.0251995.

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Polycythemia Vera (PV) is a chronic myeloproliferative neoplasm resulting from an acquired driver mutation in the JAK2 gene of hematopoietic stem and progenitor cells resulting in the overproduction of mature erythrocytes and abnormally high hematocrit, in turn leading to thromboembolic complications. Therapeutic phlebotomy is the most common treatment to reduce the hematocrit levels and consequently decrease thromboembolic risk. Here we demonstrate that, by using the iron restrictive properties of the antisense oligonucleotides against Tmprss6 mRNA, we can increase hepcidin to achieve effects

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Thungthong, Pravinwan, Supat Chamnanchanunt, Tawatchai Suwanban, Chajchawan Nakhakes, and Kunapa Iam-arunthai. "Janus kinase 2 negative polycythemia vera." Asian Biomedicine 9, no. 5 (2017): 697–700. http://dx.doi.org/10.5372/1905-7415.0905.443.

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Abstract Background A Janus kinase 2 (JAK2) mutation polycythemia vera (PV) is a common manifestation of stem cell disorder. However, available data on the clinical and treatment response of JAK2-negative PV patients are limited. Objectives We report the case and clinical course of a patient with PV and left hemiparesis who was JAK2V617-negative. Methods We conducted a literature review and compared our patient with previously published reports of JAK2-negative patients with P V. Results Our patient presented with hemiparesis without a previous history of hematological disease. He was diagnose

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Kawamura, Itta, Genzou Takemura, Hiromitsu Kanamori, et al. "Repeated phlebotomy augments angiogenesis to improve blood flow in murine ischemic legs." American Journal of Physiology-Heart and Circulatory Physiology 299, no. 2 (2010): H372—H378. http://dx.doi.org/10.1152/ajpheart.00035.2010.

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Anemia may accelerate angiogenesis in ischemic organs through its ability to augment tissue hypoxia-induced generation of several known angiogenic factors and to increase erythropoietin levels, which are also potently angiogenic. We examined the effect of controlled phlebotomy (bloodletting) on blood flow in a mouse ischemic leg model. We ligated the right femoral artery of BALB/c mice. In the phlebotomy group, 200 μl of blood were drawn from the tail vein once a week. After 4 wk, blood flow in the ischemic leg was significantly better in the phlebotomy group (flow ratio of the ischemic to non

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Ginzburg, Yelena, Kamini Kirubamoorthy, Sinari Salleh, et al. "Rusfertide (PTG-300) Induction Therapy Rapidly Achieves Hematocrit Control in Polycythemia Vera Patients without the Need for Therapeutic Phlebotomy." Blood 138, Supplement 1 (2021): 390. http://dx.doi.org/10.1182/blood-2021-149205.

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Abstract Background. Polycythemia (PV) patients with hematocrit above 45% are at increased risk of thrombotic complications and are treated with phlebotomy and/or cytoreductive therapy to reach a hematocrit target below 45%. Rusfertide (PTG-300) is a peptidic mimetic of hepcidin that is being developed for treatment of polycythemia vera (PV). A Phase 2 trial has indicated that rusfertide is effective at reducing the number of phlebotomies and maintaining hematocrit below 45% without phlebotomy in PV patients who are either high-risk or low-risk, patients treated with cytoreductive therapy (hyd

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Podoltsev, Nikolai A., Mengxin Zhu, Amer M. Zeidan, et al. "The impact of phlebotomy and hydroxyurea on survival and risk of thrombosis among older patients with polycythemia vera." Blood Advances 2, no. 20 (2018): 2681–90. http://dx.doi.org/10.1182/bloodadvances.2018021436.

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Abstract Current guidelines recommend therapeutic phlebotomy for all polycythemia vera (PV) patients and additional cytoreductive therapy (eg, hydroxyurea [HU]) for high-risk PV patients. Little is known about the impact of these therapies in the real-world setting. We conducted a retrospective cohort study of older adults diagnosed with PV from 2007 to 2013 using the linked Surveillance, Epidemiology, and End Results–Medicare database. Multivariable Cox proportional hazards models were used to assess the effect of phlebotomy and HU on overall survival (OS) and the occurrence of thrombotic eve

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Barton, James C., and Sylvia S. Bottomley. "Iron deficiency due to excessive therapeutic phlebotomy in hemochromatosis." American Journal of Hematology 65, no. 3 (2000): 223–26. http://dx.doi.org/10.1002/1096-8652(200011)65:3<223::aid-ajh8>3.0.co;2-9.

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Bernard, D. W., R. L. Bowman, F. A. Grimm, B. A. Wolf, M. B. Simson, and L. M. Shaw. "Nighttime dosing assures postdistribution sampling for therapeutic drug monitoring of digoxin." Clinical Chemistry 42, no. 1 (1996): 45–49. http://dx.doi.org/10.1093/clinchem/42.1.45.

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Abstract To study the appropriateness of phlebotomy for digoxin therapeutic drug monitoring (TDM) in outpatients, we conducted a retrospective chart review, a computer search of all previous TDM testing, and a questionnaire of all outpatients (n = 86) who had serum digoxin determinations between April 10 and April 28, 1992 (585 tests). In patients who took digoxin at the same time daily (40 patients, 300 tests), 52% of tests were performed on inappropriate samples drawn within 6 h of the last dose. No patient who took digoxin after 1700 had inappropriate tests. Phlebotomy for serum digoxin det

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Das, Soumya, Mohandoss Murugesan, and Shamee Shastry. "Effect of therapeutic phlebotomy on plasma volume in polycythemia patients." Global Journal of Transfusion Medicine 3, no. 2 (2018): 117. http://dx.doi.org/10.4103/gjtm.gjtm_27_18.

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Poh-Fitzpatrick, Maureen B., Paul J. Honig, Haewon C. Kim, and Shigeru Sassa. "Childhood-onset familial porphyria cutanea tarda: Effects of therapeutic phlebotomy." Journal of the American Academy of Dermatology 27, no. 5 (1992): 896–900. http://dx.doi.org/10.1016/0190-9622(92)70277-m.

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IJABR. "Exploring Therapeutic Phlebotomy (FASD) in the light of Ilmul Amraz (Unani Pathological Perspective)." International Journal of Advanced Biotechnology and Research 15, no. 3 (2024): 1–7. https://doi.org/10.5281/zenodo.12790036.

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<strong>Abstract</strong> Theories and philosophies of Unani medicine are based on the humoral theory postulated by Hippocrates 3000 yrs back.It is based on the concept of equilibrium and balance of natural body humours (blood, bile, black bile and phlegm). The imbalance in the quality and quantity of these humours leads to diseases whereas restoration of this balance maintains health of a person.  Its treatment is a culmination of different regimens. Regimenal therapy is one of them. It is among the non-medicinal procedures that are used for health promotion in Unani system of medicine.

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Malas, Abdullah, Shams Bufalino, Christie Hancock, and Jacob D. Bitran. "Idiopathic Erythrocytosis: Vascular Complications." Blood 138, Supplement 1 (2021): 4146. http://dx.doi.org/10.1182/blood-2021-148870.

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Abstract Idiopathic Erythrocytosis (IE) is a diagnosis of exclusion once primary and secondary causes have been eliminated; yet IE remains an enigmatic disorder. Published series from decades ago (Modan & Modan J. Hematol [1968] 14:375; Pearson & Wetherly-Mein, Clin.Lab Hematol. [1974] 1:189) have reported high rates of vascular complications (46%) and advise phlebotomy to keep the hematocrit to less than 45%. A More recent series (McMullin B.J. Hematol. [2005] 130:174) advise no need for phlebotomy in patients with no co-morbidities such as vascular disease, diabetes, or hypertension.

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Kanchana, Thirumalesh P., Vivek Kaul, Santiago J. Munoz, and Kenneth D. Rothstein. "Some patients with hereditary hemochromatosis do not require chronic therapeutic phlebotomy." Gastroenterology 120, no. 5 (2001): A566. http://dx.doi.org/10.1016/s0016-5085(08)82812-0.

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KANCHANA, T., V. KAUL, S. MUNOZ, and K. ROTHSTEIN. "Some patients with hereditary hemochromatosis do not require chronic therapeutic phlebotomy." Gastroenterology 120, no. 5 (2001): A566. http://dx.doi.org/10.1016/s0016-5085(01)82812-2.

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KÓSZÓ, FERENC, MÁRTA MORVAY, ATTILA DOBOZY, and KRISZTINA BODA. "Erythrocyte uroporphyrinogen decarboxylase activity and therapeutic phlebotomy in porphyria cutanea tarda." Journal of Porphyrins and Phthalocyanines 04, no. 08 (2000): 736–38. http://dx.doi.org/10.1002/1099-1409(200012)4:8<736::aid-jpp289>3.0.co;2-j.

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On the basis of the uroporphyrinogen decarboxylase ( UD ) activity in the erythrocytes, and the family history of the disease, different types of porphyria cutanea tarda ( PCT ) can be distinguished. In some cases, however, the distinction may involve some uncertainty (overlapping of subgroups). The question arises of whether the current erythrocyte UD activities in the different types of PCT are determined merely genetically. The erythrocyte UD activities in 72 unrelated patients with different forms of PCT (62 with type I PCT and 10 with type II PCT ), in different stages of the disease, wer

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Lima-Oliveira, Gabriel, Giuseppe Lippi, Gian Luca Salvagno, Geraldo Picheth, and Gian Cesare Guidi. "Laboratory Diagnostics and Quality of Blood Collection / Laboratorijska Dijagnostika I Kvalitet Uzimanja Uzoraka Krvi." Journal of Medical Biochemistry 34, no. 3 (2015): 288–94. http://dx.doi.org/10.2478/jomb-2014-0043.

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SummaryDiagnostic blood samples collected by phlebotomy are the most common type of biological specimens drawn and sent to laboratory medicine facilities for being analyzed, thus supporting caring physicians in patient diagnosis, follow-up and/or therapeutic monitoring. Phlebotomy, a relatively invasive medical procedure, is indeed critical for the downstream procedures accomplished either in the analytical phase made in the laboratory or in the interpretive process done by the physicians. Diagnosis, management, treatment of patients and ultimately patient safety itself can be compromised by p

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Hammons, Lindsay, Lesley Wu, Douglas Tremblay, Lukas Ronner, and Yelena Ginzburg. "Phlebotomy requirements are lower in polycythemia vera patients with low ferritin stores." Journal of Clinical Oncology 38, no. 15_suppl (2020): e19537-e19537. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e19537.

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e19537 Background: Polycythemia vera (PV) is a myeloid neoplasm of clonal red cell proliferation. Most PV patients are iron deficient at diagnosis, prior to the onset of therapeutic phlebotomy, the mainstay of treatment. More recent studies have also suggested that aberrant iron homeostasis contributes to persistently elevated hematocrit in iron deficient PV patients. In healthy individuals, iron deficiency leads to anemia such that the co-occurrence of polycythemia and iron deficiency in PV is pathological. The purpose of our study is to investigate whether iron deficiency, as defined by seru

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Al-Rahal, NidalKarim, and FatmaAbd AlHamza. "THERAPEUTIC ERYTHROCYTAPHERESIS VERSUS TRADITIONAL PHLEBOTOMY IN THE TREATMENT OF PATIENTS WITH ERYTHROCYTOSIS." International Journal of Advanced Research 4, no. 8 (2016): 509–15. http://dx.doi.org/10.21474/ijar01/1241.

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Bose, Neeta, and Hitendra Kanzariya. "Role of therapeutic apheresis and phlebotomy techniques in anaesthesia and critical care." Indian Journal of Anaesthesia 58, no. 5 (2014): 672. http://dx.doi.org/10.4103/0019-5049.144685.

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38

Ali, Asad, Hammad Zafar, Sameer Parakash, et al. "S3390 Trends in Therapeutic Phlebotomy Among Patients With Hereditary Hemochromatosis in Iowa." American Journal of Gastroenterology 116, no. 1 (2021): S1394. http://dx.doi.org/10.14309/01.ajg.0000787092.71584.86.

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Adams, Paul C. "Editorial: therapeutic phlebotomy for iron overload—start with a diagnosis before bleeding." Alimentary Pharmacology & Therapeutics 55, no. 6 (2022): 748–49. http://dx.doi.org/10.1111/apt.16780.

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Mitsuyoshi, Hironori, Kohichiroh Yasui, Kanji Yamaguchi, Masahito Minami, Takeshi Okanoue, and Yoshito Itoh. "Pathogenic Role of Iron Deposition in Reticuloendothelial Cells during the Development of Chronic Hepatitis C." International Journal of Hepatology 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/686420.

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Aim. Chronic hepatitis C (CHepC) is frequently associated with hepatic iron overload, yet mechanisms underlying iron-induced liver injury have not been elucidated. We examined the significance of iron deposition in hepatocytes (HC) and reticuloendothelial cells (REC) in CHepC.Methods. Stainable hepatic iron was scored according to the iron deposition pattern in 373 patients. The levels of serum soluble TNF-αreceptor (sTNFR2) and hepatic hepcidin mRNA and the efficacy of phlebotomy were compared among patients with different iron deposition patterns.Results. Serum transaminase levels and hepati

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IJABR. "fdgdgbfv." International Journal of Advanced Biotechnology and Research 15, no. 3 (2024): 1–7. https://doi.org/10.5281/zenodo.12790030.

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<strong>Abstract</strong> Theories and philosophies of Unani medicine are based on the humoral theory postulated by Hippocrates 3000 yrs back.It is based on the concept of equilibrium and balance of natural body humours (blood, bile, black bile and phlegm). The imbalance in the quality and quantity of these humours leads to diseases whereas restoration of this balance maintains health of a person.  Its treatment is a culmination of different regimens. Regimenal therapy is one of them. It is among the non-medicinal procedures that are used for health promotion in Unani system of medicine.

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42

Solanki, Tapan, Sachin Rohani, and Vinayak Joshi. "AYURVEDA APPROACH IN THE MANAGEMENT OF HYPERTROPHIC LICHEN PLANUS – A CASE REPORT." International Ayurvedic Medical Journal 11, no. 11 (2023): 2938–43. http://dx.doi.org/10.46607/iamj4411112023.

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Lichen planus is a dermatological condition with challenging symptoms. Conventional treatments often have limitations. This case report explores the successful Ayurvedic management of hypertrophic lichen planus in a 19- year-old male patient. The treatment involved Purgation (Virechana), oral Ayurvedic medicines, and therapeutic phlebotomy (Raktamokshana). The patient experienced significant relief from symptoms, illustrating the potential of Ayurveda in addressing complex dermatological conditions.

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Crodel, Carl C., Kathleen Jentsch-Ulrich, Lutz Jacobasch, et al. "Cytoreductive Treatment in 'Real Life' - Interim-Analysis of 434 Polycythemia Vera Patients in Germany." Blood 134, Supplement_1 (2019): 1672. http://dx.doi.org/10.1182/blood-2019-122681.

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Treatment recommendations for cytoreductive treatment of patients with polycythemia vera (PV) are well established. However, the clinical use and limitation of phlebotomies remain a matter of current debate (Barbui et al, Leukemia, 32; Heidel et al, Leukemia, 32). While multicenter trials investigating therapeutic strategies for PV have been conducted at specialized academic centers, the majority of patients is treated in an outpatient (ambulatory) setting. The aim of this study is to evaluate the 'real live' situation especially in regard to the use of phlebotomy and cytoreductive therapy in

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Noritake, Hidenao, Yoshimasa Kobayashi, Yukimasa Ooba, et al. "Improved Serum Alpha-Fetoprotein Levels after Iron Reduction Therapy in HCV Patients." ISRN Hepatology 2014 (February 10, 2014): 1–7. http://dx.doi.org/10.1155/2014/875140.

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Background and Aims. To examine the changes in serum alpha-fetoprotein (AFP) levels after iron reduction by therapeutic phlebotomy in chronic hepatitis C patients. Methods. This retrospective study included 26 chronic hepatitis C patients. The patients were developed iron depletion by repeated therapeutic phlebotomies. Results. Iron reduction therapy significantly reduced the median level of serum AFP from 13 to 7 ng/mL, ALT from 96 to 50 IU/L, gamma-glutamyl transpeptidase (GGT) from 55 to 28 IU/L, and ferritin from 191 to 10 ng/mL (P<0.001 for each). The rate of decline in the AFP level c

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Teofili, Luciana, Caterina Giovanna Valentini, Elena Rossi, and Valerio De Stefano. "Indications and use of therapeutic phlebotomy in polycythemia vera: which role for erythrocytapheresis?" Leukemia 33, no. 1 (2018): 279–81. http://dx.doi.org/10.1038/s41375-018-0304-9.

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D’Onofrio, M., A. Testa, F. Varricchio, et al. "Therapeutic erythrocytapheresis is more effective than conventional phlebotomy in patients with polycythemia vera." Transfusion and Apheresis Science 50 (May 2014): S13. http://dx.doi.org/10.1016/s1473-0502(14)50028-6.

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IJABR. "Exploring Therapeutic Phlebotomy (FASD) in the light of Ilmul Amraz (Unani Pathological Perspective)." j, no. 3 (July 20, 2024): 4. https://doi.org/10.5281/zenodo.12787889.

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Schwalier, Erik, Michael Osswald, and Andrea Laws. "Erythropoietin-Assisted Phlebotomy in Stem Cell Transplant Patients with Iron Overload." Blood 114, no. 22 (2009): 4296. http://dx.doi.org/10.1182/blood.v114.22.4296.4296.

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Abstract Abstract 4296 Background Stem cell transplantation is a potential curative treatment for hematologic malignancies. This treatment often requires repeated packed red blood cell (PRBC) transfusion requirements raising the risk of secondary hemochromatosis with each successive unit transfused. Erythropoietin-assisted phlebotomy is a potential treatment to alleviate iron overload in transfusion-dependent patients. Methods We carried out a retrospective review from 2000 to 2008 of records of both allogeneic and autologous stem cell transplant recipients treated at San Antonio Military Medi

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Lima, Tadeu Gonçalves de, Fernanda Luna Neri Benevides, Flávio Lima Esmeraldo Filho, et al. "Treatment of iron overload syndrome: a general review." Revista da Associação Médica Brasileira 65, no. 9 (2019): 1216–22. http://dx.doi.org/10.1590/1806-9282.65.9.1216.

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SUMMARY INTRODUCTION Iron overload is a broad syndrome with a large spectrum of causative etiologies that lead to iron deposition. When iron exceeds defenses, it causes oxidative damage and tissular disfunction. Treatment may prevent organ dysfunction, leading to greater life expectancy. METHODS Literature from the last five years was reviewed through the use of the PubMed database in search of treatment strategies. DISCUSSION Different pharmacological and non-pharmacological strategies are available for the treatment of iron overload and must be used according to etiology and patient complian

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Dogra, Ashu. "Role of therapeutic phlebotomy in management of case of porphyria cutanea tarda (PCT) admitted in tertiary care hospital Vadodara." Hematology & Transfusion International Journal 8, no. 1 (2020): 4–6. http://dx.doi.org/10.15406/htij.2020.08.00212.

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Porphyria cutanea tarda is the most frequent type of Porphyria worldwide & presents with skin symptoms mainly. Porphyrias can affect peripheral, autonomic and central nervous system. In Porphyria conditions there is accumulation of heme precursors 5 Aminolevulinic acid, Porphobilinogen and porphyrins which are associated with characteristic clinical feature with acute neurovisceral attacks and skin lesions. This case report summarizes Case of PCT that was successfully managed with Therapeutic Phlebotomy.

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