Log in

Relevant bibliographies by topics / Therapeutic Response against Diabetes Mellitus / Journal articles

To see the other types of publications on this topic, follow the link: Therapeutic Response against Diabetes Mellitus.

Journal articles on the topic 'Therapeutic Response against Diabetes Mellitus'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Therapeutic Response against Diabetes Mellitus.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Riya, Raj Nivedita chatterjee Sandhya Verma Chandra Shekhar Mishra. "Exploring Diabetes: Types, History, Prevelance and Role of Medicinal Plants in Management." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 1569–82. https://doi.org/10.5281/zenodo.15381436.

Full text

Abstract:

Diabetes is a chronic metabolic disorder characterized by elevated blood sugar levels, resulting from either insufficient insulin production or poor cellular response to insulin. This condition is classified into two main types: Type 1 diabetes, where the body fails to produce insulin, and Type 2 diabetes, where the body becomes resistant to insulin. The increasing prevalence of diabetes globally has prompted the exploration of alternative therapeutic approaches, particularly the use of medicinal plants. Several plant species have shown significant antidiabetic activities through mechanisms su

APA, Harvard, Vancouver, ISO, and other styles

2

Ren, Yuanyuan, Zhuozhuo Li, Wenqing Li, et al. "Arginase: Biological and Therapeutic Implications in Diabetes Mellitus and Its Complications." Oxidative Medicine and Cellular Longevity 2022 (October 26, 2022): 1–20. http://dx.doi.org/10.1155/2022/2419412.

Full text

Abstract:

Arginase is a ubiquitous enzyme in the urea cycle (UC) that hydrolyzes L-arginine to urea and L-ornithine. Two mammalian arginase isoforms, arginase1 (ARG1) and arginase2 (ARG2), play a vital role in the regulation of β-cell functions, insulin resistance (IR), and vascular complications via modulating L-arginine metabolism, nitric oxide (NO) production, and inflammatory responses as well as oxidative stress. Basic and clinical studies reveal that abnormal alterations of arginase expression and activity are strongly associated with the onset and development of diabetes mellitus (DM) and its com

APA, Harvard, Vancouver, ISO, and other styles

3

Puddu, Alessandra, Roberta Sanguineti, François Mach, Franco Dallegri, Giorgio Luciano Viviani, and Fabrizio Montecucco. "Update on the Protective Molecular Pathways Improving Pancreatic Beta-Cell Dysfunction." Mediators of Inflammation 2013 (2013): 1–14. http://dx.doi.org/10.1155/2013/750540.

Full text

Abstract:

The primary function of pancreatic beta-cells is to produce and release insulin in response to increment in extracellular glucose concentrations, thus maintaining glucose homeostasis. Deficient beta-cell function can have profound metabolic consequences, leading to the development of hyperglycemia and, ultimately, diabetes mellitus. Therefore, strategies targeting the maintenance of the normal function and protecting pancreatic beta-cells from injury or death might be crucial in the treatment of diabetes. This narrative review will update evidence from the recently identified molecular regulat

APA, Harvard, Vancouver, ISO, and other styles

4

Lanka, Goverdhan, Revanth Bathula, Manan Bhargavi, and Sarita Rajender Potlapally. "Homology modeling and molecular docking studies for the identification of novel potential therapeutics against human PHD3 as a drug target for type 2 diabetes mellitus." Journal of Drug Delivery and Therapeutics 9, no. 4 (2019): 265–73. http://dx.doi.org/10.22270/jddt.v9i4.3039.

Full text

Abstract:

PHD3 (Prolyl Hydroxylating Domain) 3 protein contains the HRE (Hypoxia Response Element) and plays an important role in regulating HIF subunits. The hydroxylating ability of PHD3 of HIF subunits makes PHD3 is a prominent therapeutic target to control type 2 diabetes mellitus. The structure based approach is used to design novel molecular entities against PHD3 protein. In this present work, a 3D homology model of PHD3 was generated by MODELLER9.9 as the experimental structure of PHD3 is not reported in the protein database. The 3d structural model of PHD3 refined through energy minimization in

APA, Harvard, Vancouver, ISO, and other styles

5

Tebulo, Kintuza Lumwako. "Therapeutic Potential of Citrus Flavonoids in Metabolic Inflammation and Insulin Resistance." Research Output Journal of Engineering and Scientific Research 4, no. 3 (2025): 23–29. https://doi.org/10.59298/rojesr/2025/4.3.2329.

Full text

Abstract:

Metabolic inflammation, or meta-inflammation, is a low-grade chronic inflammatory state associated with metabolic disorders such as obesity, type 2 diabetes mellitus (T2DM), and insulin resistance (IR). Recent evidence highlights the role of bioactive compounds, particularly citrus flavonoids, in modulating metabolic pathways and inflammatory responses. Citrus flavonoids, such as hesperidin, naringenin, nobiletin, and tangeretin, exhibit diverse biological properties including antioxidant, anti-inflammatory, and insulin-sensitizing effects. This review consolidates current findings on the mole

APA, Harvard, Vancouver, ISO, and other styles

6

Sharma, Naveen, Eun-Joo Shin, Nam Hun Kim, et al. "Far-infrared Ray-mediated Antioxidant Potentials are Important for Attenuating Psychotoxic Disorders." Current Neuropharmacology 17, no. 10 (2019): 990–1002. http://dx.doi.org/10.2174/1570159x17666190228114318.

Full text

Abstract:

Far-infrared ray (FIR) is an electromagnetic wave that produces various health benefits against pathophysiological conditions, such as diabetes mellitus, renocardiovascular disorders, stress, and depression etc. However, the therapeutic application on the FIR-mediated protective potentials remains to be further extended. To achieve better understanding on FIR-mediated therapeutic potentials, we summarized additional findings in the present study that exposure to FIR ameliorates stressful condition, memory impairments, drug dependence, and mitochondrial dysfunction in the central nervous system

APA, Harvard, Vancouver, ISO, and other styles

7

Fang, Zhao-hui, Xian-chun Duan, Jin-dong Zhao, Yuan-jie Wu, and Meng-meng Liu. "Novel Polysaccharide H-1-2 from Pseudostellaria Heterophylla Alleviates Type 2 Diabetes Mellitus." Cellular Physiology and Biochemistry 49, no. 3 (2018): 1037–47. http://dx.doi.org/10.1159/000493284.

Full text

Abstract:

Background/Aims: To investigate the potential therapeutic effect of novel polysaccharide H-1-2 from pseudostellaria heterophylla against type 2 Diabetes Mellitus (T2DM) and elucidate the underling molecular mechanisms. Methods: Relative expression of HIF1α and Sirt1 in T2DM patients was determined via real-time PCR. The direct binding of HIF1α on Sirt1 promoter was validated by ChIP assay. The inhibitory regulation of Sirt1 by HIF1α was analyzed using luciferase reporter assay. The endogenous protein of HIF1α and Sirt1 in response to H-1-2 treatment was quantified by western blotting. The bloo

APA, Harvard, Vancouver, ISO, and other styles

8

Yang, Xiumei, Cuilian Yang, Wenjing Lu, and Xiumei Yang. "Visnagin Attenuates Gestational Diabetes Mellitus in Streptozotocin-induced Diabetic Pregnant Rats via Regulating Dyslipidemia, Oxidative Stress, and Inflammatory Response." Pharmacognosy Magazine 19, no. 1 (2022): 31–40. http://dx.doi.org/10.1177/09731296221137440.

Full text

Abstract:

Background: Gestational diabetes mellitus (GDM) is a condition of glucose intolerance and insulin resistance only diagnosed during pregnancy. GDM has exhibited several adverse effects on both mother and offspring. The current research focuses on discovering visnagin’s beneficial properties against the streptozotocin (STZ)-induced GDM in rats via alleviating the inflammation and oxidative stress. Materials and Methods: GDM was caused in the pregnant rats by the administration of 25 mg/kg of STZ by the intraperitoneal route and then treated with 20 mg/kg of visnagin for 20 consecutive days. The

APA, Harvard, Vancouver, ISO, and other styles

9

Abbas, Ghulam, Quazi M. I. Haq, Ahmad Hamaed, Mohammed Al-Sibani, and Hidayat Hussain. "Glucagon and Glucagon-like Peptide-1 Receptors: Promising Therapeutic Targets for an Effective Management of Diabetes Mellitus." Current Pharmaceutical Design 26, no. 4 (2020): 501–8. http://dx.doi.org/10.2174/1381612826666200131143231.

Full text

Abstract:

: G-protein-coupled receptors (GPCRs) are membrane-bound proteins, which are responsible for the detection of extracellular stimuli and the origination of intracellular responses. Both glucagon and glucagon-like peptide-1 (GLP-1) receptors belong to G protein-coupled receptor (GPCR) superfamily. Along with insulin, glucagon and GLP-1 are critical hormones for maintaining normal serum glucose within the human body. Glucagon generally plays its role in the liver through cyclic adenosine monophosphate (cAMP), where it compensates for the action of insulin. GLP-1 is secreted by the L-cells of the

APA, Harvard, Vancouver, ISO, and other styles

10

Tripathi, Deepak, Rajesh Kumar Radhakrishnan, Ramya Sivangala Thandi, et al. "IL-22 reduces the mortality of type 2 diabetes mellitus (T2DM) mice infected with Mycobacterium tuberculosis." Journal of Immunology 202, no. 1_Supplement (2019): 181.19. http://dx.doi.org/10.4049/jimmunol.202.supp.181.19.

Full text

Abstract:

Abstract IL-22 play an important role in protective immune responses against bacterial infections including Mtb and maintains homeostasis by regulating excess inflammation. IL-22 can also regulate glucose homeostasis, suggesting IL-22 pathway as a novel target for therapeutic intervention. Previously, we developed a mouse model of type 2 diabetes mellitus (T2DM) and found that pathological immune response enhances mortality of Mycobacterium tuberculosis (Mtb) infected T2DM mice. In the current study, we determined the role of IL-22 during Mtb infection in T2DM mice. We found innate lymphoid 3

APA, Harvard, Vancouver, ISO, and other styles

11

Rowe, Patricia M., Mahendra Kumar Trivedi, Gopal Nayak, Alice Branton, and Dahryn Trivedi. "Structural and Natural Isotopic Abundance Analysis of Magnesium Gluconate Treated with Energy of Consciousness (The Trivedi Effect®) Using LC-MS and NMR." Chemical and Biomolecular Engineering 2, no. 3 (2017): 124–34. https://doi.org/10.5281/zenodo.845252.

Full text

Abstract:

The current research article was aimed to investigate the impact of The Trivedi Effect®- Energy of Consciousness Healing Treatment on the structural properties and isotopic abundance ratio (PM+1/PM and PM+2/PM) of magnesium gluconate using LC-MS and NMR spectroscopy. Magnesium gluconate was divided into two parts – one part was control, and another part was treated with The Trivedi Effect® remotely by eighteen renowned Biofield Energy Healers and defined as the Trivedi Effect® Treated sample. The liquid chromatogram of the control sample showed two peaks at Rt of 1.81 and 2.06 min, whereas the

APA, Harvard, Vancouver, ISO, and other styles

12

Henderson, Sally Jean, Mahendra Kumar Trivedi, Gopal Nayak, Alice Branton, and Dahryn Trivedi. "Structural and Natural Isotopic Abundance Analysis of Magnesium Gluconate Treated with Energy of Consciousness (The Trivedi Effect®) Using LC-MS and NMR." Chemical and Biomolecular Engineering 2, no. 3 (2017): 124–34. https://doi.org/10.5281/zenodo.846992.

Full text

Abstract:

The current research article was aimed to investigate the impact of The Trivedi Effect®- Energy of Consciousness Healing Treatment on the structural properties and isotopic abundance ratio (PM+1/PM and PM+2/PM) of magnesium gluconate using LC-MS and NMR spectroscopy. Magnesium gluconate was divided into two parts – one part was control, and another part was treated with The Trivedi Effect® remotely by eighteen renowned Biofield Energy Healers and defined as the Trivedi Effect® Treated sample. The liquid chromatogram of the control sample showed two peaks at Rt of 1.81 and 2.06 min, whereas the

APA, Harvard, Vancouver, ISO, and other styles

13

Lee, Younghay, Sun-Hye Shin, Kyung-Ah Cho, et al. "Administration of Tonsil-Derived Mesenchymal Stem Cells Improves Glucose Tolerance in High Fat Diet-Induced Diabetic Mice via Insulin-Like Growth Factor-Binding Protein 5-Mediated Endoplasmic Reticulum Stress Modulation." Cells 8, no. 4 (2019): 368. http://dx.doi.org/10.3390/cells8040368.

Full text

Abstract:

Type 2 diabetes mellitus (T2DM) is a prevalent chronic metabolic disorder accompanied by high blood glucose, insulin resistance, and relative insulin deficiency. Endoplasmic reticulum (ER) stress induced by high glucose and free fatty acids has been suggested as one of the main causes of β-cell dysfunction and death in T2DM. Stem cell-derived insulin-secreting cells were recently suggested as a novel therapy for diabetes. In the present study, we demonstrate the therapeutic potential of tonsil-derived mesenchymal stem cells (TMSCs) to treat high-fat diet (HFD)-induced T2DM. To explore whether

APA, Harvard, Vancouver, ISO, and other styles

14

Abu-Khudir, Rasha, Gehan M. Badr, Heba Ibrahim Abd El-Moaty, et al. "Garden Cress Seed Oil Abrogates Testicular Oxidative Injury and NF-kB-Mediated Inflammation in Diabetic Mice." International Journal of Molecular Sciences 24, no. 20 (2023): 15478. http://dx.doi.org/10.3390/ijms242015478.

Full text

Abstract:

Diabetes mellitus is a metabolic disorder associated with various complications encompassing male reproductive dysfunction. The present study aimed to investigate the therapeutic potential of biologically active Lepidium sativum seed oil (LSO) against the testicular dysfunction associated with streptozotocin (STZ)-induced diabetes. Male adults (n = 24) were divided into four groups: control, LSO-administered, diabetic (D), and LSO-treated diabetic (D+LSO) groups. LSO was extracted from L. sativum seeds, and its chemical composition was determined using GC-MS. Serum testosterone levels, testicu

APA, Harvard, Vancouver, ISO, and other styles

15

Sun, Hai-Jian, Dan Chen, Pei-Yao Wang та ін. "Salusin-β Is Involved in Diabetes Mellitus-Induced Endothelial Dysfunction via Degradation of Peroxisome Proliferator-Activated Receptor Gamma". Oxidative Medicine and Cellular Longevity 2017 (2017): 1–14. http://dx.doi.org/10.1155/2017/6905217.

Full text

Abstract:

The pathophysiological mechanisms for vascular lesions in diabetes mellitus (DM) are complex, among which endothelial dysfunction plays a vital role. Therapeutic target against endothelial injury may provide critical venues for treatment of diabetic vascular diseases. We recently identified that salusin-β contributed to high glucose-induced endothelial cell apoptosis. However, the roles of salusin-β in DM-induced endothelial dysfunction remain largely elusive. Male C57BL/6J mice were used to induce type 2 diabetes mellitus (T2DM) model. Human umbilical vein endothelial cells (HUVECs) were cult

APA, Harvard, Vancouver, ISO, and other styles

16

Montaño, Dolly E., and Kerstin Voigt. "Host Immune Defense upon Fungal Infections with Mucorales: Pathogen-Immune Cell Interactions as Drivers of Inflammatory Responses." Journal of Fungi 6, no. 3 (2020): 173. http://dx.doi.org/10.3390/jof6030173.

Full text

Abstract:

During the last few decades, mucormycosis has emerged as one of the most common fungal infections, following candidiasis and aspergillosis. The fungal order responsible for causing mucormycosis is the Mucorales. The main hallmarks of this infection include the invasion of blood vessels, infarction, thrombosis, and tissue necrosis, which are exhibited at the latest stages of the infection. Therefore, the diagnosis is often delayed, and the rapid progression of the infection severely endangers the life of people suffering from diabetes mellitus, hematological malignancies, or organ transplantati

APA, Harvard, Vancouver, ISO, and other styles

17

Ianuà, Eleonora, Mario Caldarelli, Giuseppe De Matteis, Rossella Cianci, and Giovanni Gambassi. "Hematological Complications in a COVID-19 Patient: A Case Report." Diseases 12, no. 1 (2023): 5. http://dx.doi.org/10.3390/diseases12010005.

Full text

Abstract:

Hemophilia A is a hemorrhagic disorder caused by insufficient or inadequate coagulation factor VIII activity. Two different forms are described: congenital, hereditary X-linked, and acquired. Acquired hemophilia A (AHA) is a rare condition and it is defined by the production of autoantibodies neutralizing factor VIII, known as inhibitors. We report the case of a 72-year-old man with a clinical diagnosis of AHA after SARS-CoV-2 infection, which has been described in association with several hematological complications. SARS-CoV-2 infection could represent the immunological trigger for the devel

APA, Harvard, Vancouver, ISO, and other styles

18

Ji, Lijun, Shuaijie Lou, Yi Fang, et al. "Patchouli Alcohol Protects the Heart against Diabetes-Related Cardiomyopathy through the JAK2/STAT3 Signaling Pathway." Pharmaceuticals 17, no. 5 (2024): 631. http://dx.doi.org/10.3390/ph17050631.

Full text

Abstract:

Diabetic cardiomyopathy (DCM) represents a common pathological state brought about by diabetes mellitus (DM). Patchouli alcohol (PatA) is known for its diverse advantageous effects, notably its anti-inflammatory properties and protective role against metabolic disorders. Despite this, the influence of PatA on DCM remains relatively unexplored. To explore the effect of PatA on diabetes-induced cardiac injury and dysfunction in mice, streptozotocin (STZ) was used to mimic type 1 diabetes in mice. Serological markers and echocardiography show that PatA treatment protects the heart against cardiom

APA, Harvard, Vancouver, ISO, and other styles

19

Miller, Brandi, Rabina Mainali, Ravinder Nagpal, and Hariom Yadav. "A Newly Developed Synbiotic Yogurt Prevents Diabetes by Improving the Microbiome–Intestine–Pancreas Axis." International Journal of Molecular Sciences 22, no. 4 (2021): 1647. http://dx.doi.org/10.3390/ijms22041647.

Full text

Abstract:

The prevalence of type 2 diabetes mellitus (T2D) is increasing worldwide, and there are no long-term preventive strategies to stop this growth. Emerging research shows that perturbations in the gut microbiome significantly contribute to the development of T2D, while microbiome modulators may be beneficial for T2D prevention. However, microbiome modulators that are effective, safe, affordable, and able to be administered daily are not yet available. Based on our previous pro- and prebiotic studies, we developed a novel synbiotic yogurt comprised of human-origin probiotics and plant-based prebio

APA, Harvard, Vancouver, ISO, and other styles

20

Gerber, Gary Richard, Mahendra Kumar Trivedi, Gopal Nayak, Alice Branton, and Dahryn Trivedi. "Structural and Natural Isotopic Abundance Analysis of Magnesium Gluconate Treated with Energy of Consciousness (The Trivedi Effect®) Using LC-MS and NMR." Chemical and Biomolecular Engineering 2, no. 3 (2017): 124–34. https://doi.org/10.5281/zenodo.839089.

Full text

Abstract:

The current research article was aimed to investigate the impact of The Trivedi Effect®- Energy of Consciousness Healing Treatment on the structural properties and isotopic abundance ratio (PM+1/PM and PM+2/PM) of magnesium gluconate using LC-MS and NMR spectroscopy. Magnesium gluconate was divided into two parts – one part was control, and another part was treated with The Trivedi Effect® remotely by eighteen renowned Biofield Energy Healers and defined as the Trivedi Effect® Treated sample. The liquid chromatogram of the control sample showed two peaks at Rt of 1.81 and 2.06 min, whereas the

APA, Harvard, Vancouver, ISO, and other styles

21

Usman, Faisal, Hamid Saeed Shah, Sumera Zaib та ін. "Fabrication and Biological Assessment of Antidiabetic α-Mangostin Loaded Nanosponges: In Vitro, In Vivo, and In Silico Studies". Molecules 26, № 21 (2021): 6633. http://dx.doi.org/10.3390/molecules26216633.

Full text

Abstract:

Type 2 diabetes mellitus has been a major health issue with increasing morbidity and mortality due to macrovascular and microvascular complications. The urgent need for improved methods to control hyperglycemic complications reiterates the development of innovative preventive and therapeutic treatment strategies. In this perspective, xanthone compounds in the pericarp of the mangosteen fruit, especially α-mangostin (MGN), have been recognized to restore damaged pancreatic β-cells for optimal insulin release. Therefore, taking advantage of the robust use of nanotechnology for targeted drug deli

APA, Harvard, Vancouver, ISO, and other styles

22

Harford, Karen A., Clare M. Reynolds, Fiona C. McGillicuddy, and Helen M. Roche. "Fats, inflammation and insulin resistance: insights to the role of macrophage and T-cell accumulation in adipose tissue." Proceedings of the Nutrition Society 70, no. 4 (2011): 408–17. http://dx.doi.org/10.1017/s0029665111000565.

Full text

Abstract:

High-fat diet-induced obesity is associated with a chronic state of low-grade inflammation, which pre-disposes to insulin resistance (IR), which can subsequently lead to type 2 diabetes mellitus. Macrophages represent a heterogeneous population of cells that are instrumental in initiating the innate immune response. Recent studies have shown that macrophages are key mediators of obesity-induced IR, with a progressive infiltration of macrophages into obese adipose tissue. These adipose tissue macrophages are referred to as classically activated (M1) macrophages. They release cytokines such as I

APA, Harvard, Vancouver, ISO, and other styles

23

Goncharov, A. G., V. V. Shupletsova, N. M. Todosenko, E. A. Goncharova та L. S. Litvinova. "Production of growth factors, pro – and anti-inflammatory cytokines by postnatal MMSCs from various tissue sources during in vitro co-cultivation with immunoisolated pancreatic β-cells". Russian Journal of Immunology 24, № 4 (2021): 477–82. http://dx.doi.org/10.46235/1028-7221-1058-pog.

Full text

Abstract:

The article presents the results of evaluating growth factors, pro – and anti-inflammatory cytokine production by multipotent mesenchymal stem cell cultures under the conditions of co-cultivation with immuno-isolated beta-cells of the pancreas. β-cell transplantation is a minimally invasive therapeutic approach (compared to transplantation of entire pancreas), and it provides better metabolic control with respect to insulin administration. However, when transplanting β-cells, there is always a risk of immune rejection of the grafted cells. It is generally recognized that encapsulation is an ef

APA, Harvard, Vancouver, ISO, and other styles

24

Mann, Gagandeep, Michael C. Riddell, and Olasunkanmi A. J. Adegoke. "Effects of Acute Muscle Contraction on the Key Molecules in Insulin and Akt Signaling in Skeletal Muscle in Health and in Insulin Resistant States." Diabetology 3, no. 3 (2022): 423–46. http://dx.doi.org/10.3390/diabetology3030032.

Full text

Abstract:

Insulin signaling plays a key role in glucose uptake, glycogen synthesis, and protein and lipid synthesis. In insulin-resistant states like obesity and type 2 diabetes mellitus, these processes are dysregulated. Regular physical exercise is a potential therapeutic strategy against insulin resistance, as an acute bout of exercise increases glucose disposal during the activity and for hours into recovery. Chronic exercise increases the activation of proteins involved in insulin signaling and increases glucose transport, even in insulin resistant states. Here, we will focus on the effect of acute

APA, Harvard, Vancouver, ISO, and other styles

25

Grey, Shane T., Maria B. Arvelo, Wendy Hasenkamp, Fritz H. Bach та Christiane Ferran. "A20 Inhibits Cytokine-Induced Apoptosis and Nuclear Factor κB–Dependent Gene Activation in Islets". Journal of Experimental Medicine 190, № 8 (1999): 1135–46. http://dx.doi.org/10.1084/jem.190.8.1135.

Full text

Abstract:

Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease resulting from apoptotic destruction of β cells in the islets of Langerhans. Low expression of antioxidants and a predilection to produce nitric oxide (NO) have been shown to underscore β cell apoptosis. With this perspective in mind, we questioned whether β cells could mount an induced protective response to inflammation. Here we show that human and rat islets can be induced to rapidly express the antiapoptotic gene A20 after interleukin (IL)-1β activation. Overexpression of A20 by means of adenovirus-mediated gene transfer p

APA, Harvard, Vancouver, ISO, and other styles

26

Chhabra, Kavaljit H., Huijing Xia, Kim Brint Pedersen, Robert C. Speth, and Eric Lazartigues. "Pancreatic angiotensin-converting enzyme 2 improves glycemia in angiotensin II-infused mice." American Journal of Physiology-Endocrinology and Metabolism 304, no. 8 (2013): E874—E884. http://dx.doi.org/10.1152/ajpendo.00490.2012.

Full text

Abstract:

An overactive renin-angiotensin system (RAS) is known to contribute to type 2 diabetes mellitus (T2DM). Although ACE2 overexpression has been shown to be protective against the overactive RAS, a role for pancreatic ACE2, particularly in the islets of Langerhans, in regulating glycemia in response to elevated angiotensin II (Ang II) levels remains to be elucidated. This study examined the role of endogenous pancreatic ACE2 and the impact of elevated Ang II levels on the enzyme's ability to alleviate hyperglycemia in an Ang II infusion mouse model. Male C57bl/6J mice were infused with Ang II or

APA, Harvard, Vancouver, ISO, and other styles

27

Zhang, Jiahui, Fnu Anshul, Joshua D. Breidenbach, Jing Liu, and James Shaffner. "NRF2: A potential target for the treatment of diabetic nephropathy." Diabetic Nephropathy 1, no. 1 (2021): 27–32. http://dx.doi.org/10.2478/dine-2021-0006.

Full text

Abstract:

Abstract One of the major complications of diabetes mellitus is diabetic nephropathy (DN), the pathogenesis of which is primarily driven by oxidative stress. As a major regulator of antioxidant responses, the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) has recently attracted much interest. NRF2 is a primary defense mechanism against the cytotoxic effects of oxidative stress, involving heterogeneous detoxification, the production of antioxidants and anti-inflammatory molecules, DNA repair, nuclear chaperones, and proteasome systems. A myriad of studies in pre-clinica

APA, Harvard, Vancouver, ISO, and other styles

28

Bruhn, Kevin, Paul Pantapalangkoor, Travis Nielsen, et al. "Diabetes exacerbates infection severity due to hyperinflammation rather than neutrophil defects (INM7P.425)." Journal of Immunology 192, no. 1_Supplement (2014): 123.3. http://dx.doi.org/10.4049/jimmunol.192.supp.123.3.

Full text

Abstract:

Abstract Patients with diabetes mellitus are at increased risk of dying from Gram negative bacterial infections. This excess mortality is often attributed to immune suppression, including neutrophil dysfunction. However, diabetic hosts also exhibit increased inflammatory responses to LPS. Here we show that lethal infections with Acinetobacter baumannii in diabetic mice are driven by LPS interactions with TLR4, as opposed to neutrophil defects. Mice made diabetic either by streptozotocin (Type 1) or diet induced obesity (Type 2) were hypersusceptible to lethality from A. baumannii bacteremia, w

APA, Harvard, Vancouver, ISO, and other styles

29

Bernardi, Stella, Giorgio Zauli, Christos Tikellis, et al. "TNF-related apoptosis-inducing ligand significantly attenuates metabolic abnormalities in high-fat-fed mice reducing adiposity and systemic inflammation." Clinical Science 123, no. 9 (2012): 547–55. http://dx.doi.org/10.1042/cs20120176.

Full text

Abstract:

TRAIL [TNF (tumour necrosis factor)-related apoptosis-inducing ligand] has recently been shown to ameliorate the natural history of DM (diabetes mellitus). It has not been determined yet whether systemic TRAIL delivery would prevent the metabolic abnormalities due to an HFD [HF (high-fat) diet]. For this purpose, 27 male C57bl6 mice aged 8 weeks were randomly fed on a standard diet, HFD or HFD+TRAIL for 12 weeks. TRAIL was delivered weekly by intraperitoneal injection. Body composition was evaluated; indirect calorimetry studies, GTT (glucose tolerance test) and ITT (insulin tolerance test) we

APA, Harvard, Vancouver, ISO, and other styles

30

Ku, Cheol Ryong, Kyong Yeun Jung, Chang Ho Ahn, et al. "COVID-19 Vaccination for Endocrine Patients: A Position Statement from the Korean Endocrine Society." Endocrinology and Metabolism 36, no. 4 (2021): 757–65. http://dx.doi.org/10.3803/enm.2021.404.

Full text

Abstract:

Since the first outbreak of coronavirus disease 2019 (COVID-19), ongoing efforts have been made to discover an efficacious vaccine against COVID-19 to combat the pandemic. In most countries, both mRNA and DNA vaccines have been administered, and their side effects have also been reported. The clinical course of COVID-19 and the effects of vaccination against COVID-19 are both influenced by patients’ health status and involve a systemic physiological response. In view of the systemic function of endocrine hormones, endocrine disorders themselves and the therapeutics used to treat them can influ

APA, Harvard, Vancouver, ISO, and other styles

31

Srivastava, Prakhar, and Karthikeyan Sivashanmugam. "Combinatorial Drug Therapy for Controlling Pseudomonas aeruginosa and Its Association With Chronic Condition of Diabetic Foot Ulcer." International Journal of Lower Extremity Wounds 19, no. 1 (2019): 7–20. http://dx.doi.org/10.1177/1534734619873785.

Full text

Abstract:

Diabetic foot ulcer (DFU) is a major complication of diabetes mellitus, major observations of DFU cases have reported on amputation of foot region, and microbial bioburden during DFU is a major cause that affects healing of the wound regions. Pathogenic microbes are routinely isolated from these wound regions, especially Staphylococcus, Pseudomonas, Klebsiella, and Escherichia coli have been reported, whereas higher prevalence of Pseudomonas species during chronic condition in the deeper part of the wound, when left untreated, leads to gangrene. Multiple drug-resistant Pseudomonas strains are

APA, Harvard, Vancouver, ISO, and other styles

32

Gharbi, Jawhar, Ikbel Hadj Hassine, Mouna Hassine, et al. "Viral Protein VP1 Virus-like Particles (VLP) of CVB4 Induces Protective Immunity against Lethal Challenges with Diabetogenic E2 and Wild Type JBV Strains in Mice Model." Viruses 15, no. 4 (2023): 878. http://dx.doi.org/10.3390/v15040878.

Full text

Abstract:

Several epidemiological studies demonstrated that coxsackievirus B4 (CVB4) causes viral pancreatitis and can ultimately result in type 1 diabetes mellitus (T1D). Prevention of CVB4 infection is therefore highly desirable. There is currently no vaccine or antiviral therapeutic reagent in clinical use. VLP are structurally similar to native virus particles and therefore are far better immunogens than any other subunit vaccines. Many studies have shown the potential of capsid protein VP1 on providing protective effects from different viral strains. In this study, we contributed towards the develo

APA, Harvard, Vancouver, ISO, and other styles

33

Yoshino, Satoshi, Emi Ishida, Kazuhiko Horiguchi, et al. "Mixed-Lineage Leukaemia Gene Regulates Glucose-Sensitive Gene Expression and Insulin Secretion in Pancreatic Beta Cells." International Journal of Molecular Sciences 25, no. 9 (2024): 4704. http://dx.doi.org/10.3390/ijms25094704.

Full text

Abstract:

The escalating prevalence of diabetes mellitus underscores the need for a comprehensive understanding of pancreatic beta cell function. Interest in glucose effectiveness has prompted the exploration of novel regulatory factors. The myeloid/lymphoid or mixed-lineage leukaemia gene (MLL) is widely recognised for its role in leukemogenesis and nuclear regulatory mechanisms through its histone methyltransferase activity in active chromatin. However, its function within pancreatic endocrine tissues remains elusive. Herein, we unveil a novel role of MLL in glucose metabolism and insulin secretion. M

APA, Harvard, Vancouver, ISO, and other styles

34

Lotfy, Mohamed, Abdallah Khalaf, Faisal AlBarghouthy, et al. "Effects of Conocarpus lancifolius and crocin on superoxide dismutase and protein kinase B genes and protein expressions in diabetic rats." PLOS One 20, no. 6 (2025): e0326676. https://doi.org/10.1371/journal.pone.0326676.

Full text

Abstract:

Background Diabetes mellitus, characterized by chronic hyperglycemia, is a global health challenge. Effective management strategies often focus on improving insulin sensitivity and enhancing antioxidant defenses to mitigate diabetes-related complications. This study explored the therapeutic potential of Conocarpus lancifolius (Co) and crocin in modulating insulin signaling and antioxidant gene expression in diabetic rats. Methods Male Wistar rats were rendered diabetic via alloxan injection and treated orally with C. lancifolius and crocin. Control groups included normal healthy control and un

APA, Harvard, Vancouver, ISO, and other styles

35

Sweas, Kathryn Regina, Mahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi, and Gopal Nayak. "Evaluation of the Impact of the Trivedi Effect® -Energy of Consciousness on the Structure and Isotopic Abundance Ratio of Magnesium Gluconate Using LC-MS and NMR Spectroscopy." American Journal of Biomedical and Life Sciences 5, no. 1 (2017): 6–15. https://doi.org/10.5281/zenodo.835341.

Full text

Abstract:

Magnesium gluconate is a classical pharmaceutical/nutraceutical compound used as a magnesium ion source for the prevention and treatment of hypomagnesemia. The present study was aimed to investigate the effect of The Trivedi Effect® - Energy of Consciousness Healing Treatment (Biofield Energy Healing Treatment) on magnesium gluconate for the change in the structural properties and isotopic abundance ratio (PM+1/PM and PM+2/PM) using LC-MS and NMR spectroscopy. Magnesium gluconate was divided into two parts – one part was control, and another part was treated with The Trivedi Effect® - Biofield

APA, Harvard, Vancouver, ISO, and other styles

36

Ku, Sae-Kwang, and Jong-Sup Bae. "Vicenin-2 and scolymoside inhibit high-glucose-induced vascular inflammation in vitro and in vivo." Canadian Journal of Physiology and Pharmacology 94, no. 3 (2016): 287–95. http://dx.doi.org/10.1139/cjpp-2015-0215.

Full text

Abstract:

The vascular inflammatory process has been suggested to play a key role in the initiation and progression of atherosclerosis, a major complication of diabetes mellitus. Thus, in this study, we attempted to determine whether 2 structurally related flavonoids found in Cyclopia subternata, vicenin-2 and scolymoside, can suppress high-glucose (HG)-induced vascular inflammatory processes in human umbilical vein endothelial cells (HUVECs) and mice. The effects of vicenin-2 and scolymoside on HG-induced vascular inflammation were determined by measuring vascular permeability, leukocyte adhesion and m

APA, Harvard, Vancouver, ISO, and other styles

37

Almutairi, Saeedah Musaed. "Metabolic Impairment of Natural Killer Cells in Type 2 Diabetes (T2D) Individuals: A Double-Edged Sword Elevating Susceptibility to Infections and Cancer." Biosciences Biotechnology Research Asia 21, no. 2 (2024): 633–44. http://dx.doi.org/10.13005/bbra/3252.

Full text

Abstract:

ABSTRACT: Glucose metabolism disturbances, such as the intricate realm of type 2 diabetes mellitus (T2DM), cast a captivating spell on the biological landscape of natural killer cells (NK cells). However, the scientific tapestry depicting the abundance and functionality of NK cells in T2DM remains an enigma, with studies yielding inconsistent findings. Some reports have unveiled a decline in peripheral NK cell numbers among T2DM patients compared to their healthy counterparts 1, while others have painted a different picture, suggesting similar levels of NK cells between T2DM patients and contr

APA, Harvard, Vancouver, ISO, and other styles

38

Griffin, John Lawrence, Mahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi, and Gopal Nayak. "Evaluation of the Impact of the Trivedi Effect® -Energy of Consciousness on the Structure and Isotopic Abundance Ratio of Magnesium Gluconate Using LC-MS and NMR Spectroscopy." American Journal of Biomedical and Life Sciences 5, no. 1 (2017): 6–15. https://doi.org/10.5281/zenodo.884142.

Full text

Abstract:

Magnesium gluconate is a classical pharmaceutical/nutraceutical compound used as a magnesium ion source for the prevention and treatment of hypomagnesemia. The present study was aimed to investigate the effect of The Trivedi Effect® - Energy of Consciousness Healing Treatment (Biofield Energy Healing Treatment) on magnesium gluconate for the change in the structural properties and isotopic abundance ratio (PM+1/PM and PM+2/PM) using LC-MS and NMR spectroscopy. Magnesium gluconate was divided into two parts – one part was control, and another part was treated with The Trivedi Effect® - Biofield

APA, Harvard, Vancouver, ISO, and other styles

39

Weigand, Tim, Florian Colbatzky, Tilman Pfeffer, et al. "A Global Cndp1-Knock-Out Selectively Increases Renal Carnosine and Anserine Concentrations in an Age- and Gender-Specific Manner in Mice." International Journal of Molecular Sciences 21, no. 14 (2020): 4887. http://dx.doi.org/10.3390/ijms21144887.

Full text

Abstract:

Carnosinase 1 (CN1) is encoded by the Cndp1 gene and degrades carnosine and anserine, two natural histidine-containing dipeptides. In vitro and in vivo studies suggest carnosine- and anserine-mediated protection against long-term sequelae of reactive metabolites accumulating, e.g., in diabetes mellitus. We have characterized the metabolic impact of CN1 in 11- and 55-week-old Cndp1-knockout (Cndp1-KO) mice and litter-matched wildtypes (WT). In Cndp1-KO mice, renal carnosine and anserine concentrations were gender-specifically increased 2- to 9-fold, respectively in the kidney and both most abun

APA, Harvard, Vancouver, ISO, and other styles

40

Zina, Rafaela, Eva Cunha, Isa Serrano, Elisabete Silva, Luís Tavares, and Manuela Oliveira. "Nisin Z Potential for the Control of Diabetic Foot Infections Promoted by Pseudomonas aeruginosa Persisters." Antibiotics 12, no. 5 (2023): 794. http://dx.doi.org/10.3390/antibiotics12050794.

Full text

Abstract:

Diabetic foot ulcers (DFU) are a major complication of diabetes mellitus and a public health concern worldwide. The ability of P. aeruginosa to form biofilms is a key factor responsible for the chronicity of diabetic foot infections (DFIs) and frequently associated with the presence of persister cells. These are a subpopulation of phenotypic variants highly tolerant to antibiotics for which new therapeutic alternatives are urgently needed, such as those based on antimicrobial peptides. This study aimed to evaluate the inhibitory effect of nisin Z on P. aeruginosa DFI persisters. To induce the

APA, Harvard, Vancouver, ISO, and other styles

41

Yang, Jia, Yang Liu, Minghui Wang, et al. "Repair Effect of Umbilical Cord Mesenchymal Stem Cells Embedded in Hydrogel on Mouse Insulinoma 6 Cells Injured by Streptozotocin." Polymers 16, no. 13 (2024): 1845. http://dx.doi.org/10.3390/polym16131845.

Full text

Abstract:

Umbilical cord mesenchymal stem cells (UC-MSCs) possess the capabilities of differentiation and immune modulation, which endow them with therapeutic potential in the treatment of type 2 diabetes mellitus (T2DM). In this study, to investigate the repair mechanism of UC-MSCs in hydrogel on pancreatic β-cells in diabetes, mouse insulinoma 6 (MIN-6) cells damaged by streptozotocin (STZ) in vitro were used in co-culture with UC-MSCs in hydrogel (UC-MSCs + hydrogel). It was found that UC-MSCs + hydrogel had a significant repair effect on injured MIN-6 cells, which was better than the use of UC-MSCs

APA, Harvard, Vancouver, ISO, and other styles

42

Stromsnas, Johanna Catharina, and Mahendra Kumar Trivedi. "Structural and Natural Isotopic Abundance Analysis of Magnesium Gluconate Treated with Energy of Consciousness (The Trivedi Effect®) Using LC-MS and NMR." Chemical and Biomolecular Engineering 2, no. 3 (2017): 124–34. https://doi.org/10.5281/zenodo.840626.

Full text

Abstract:

The current research article was aimed to investigate the impact of The Trivedi Effect®- Energy of Consciousness Healing Treatment on the structural properties and isotopic abundance ratio (PM+1/PM and PM+2/PM) of magnesium gluconate using LC-MS and NMR spectroscopy. Magnesium gluconate was divided into two parts – one part was control, and another part was treated with The Trivedi Effect® remotely by eighteen renowned Biofield Energy Healers and defined as the Trivedi Effect® Treated sample. The liquid chromatogram of the control sample showed two peaks at Rt of 1.81 and 2.06 min, whereas the

APA, Harvard, Vancouver, ISO, and other styles

43

Rahman, Md Mominur, Md Saidur Rahaman, Md Rezaul Islam, et al. "Role of Phenolic Compounds in Human Disease: Current Knowledge and Future Prospects." Molecules 27, no. 1 (2021): 233. http://dx.doi.org/10.3390/molecules27010233.

Full text

Abstract:

Inflammation is a natural protective mechanism that occurs when the body’s tissue homeostatic mechanisms are disrupted by biotic, physical, or chemical agents. The immune response generates pro-inflammatory mediators, but excessive output, such as chronic inflammation, contributes to many persistent diseases. Some phenolic compounds work in tandem with nonsteroidal anti-inflammatory drugs (NSAIDs) to inhibit pro-inflammatory mediators’ activity or gene expression, including cyclooxygenase (COX). Various phenolic compounds can also act on transcription factors, such as nuclear factor-κB (NF-κB)

APA, Harvard, Vancouver, ISO, and other styles

44

Foty, Joseph Michael, Mahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi, and Gopal Nayak. "Evaluation of the Impact of the Trivedi Effect® -Energy of Consciousness on the Structure and Isotopic Abundance Ratio of Magnesium Gluconate Using LC-MS and NMR Spectroscopy." American Journal of Biomedical and Life Sciences 5, no. 1 (2017): 6–15. https://doi.org/10.5281/zenodo.883580.

Full text

Abstract:

Magnesium gluconate is a classical pharmaceutical/nutraceutical compound used as a magnesium ion source for the prevention and treatment of hypomagnesemia. The present study was aimed to investigate the effect of The Trivedi Effect® - Energy of Consciousness Healing Treatment (Biofield Energy Healing Treatment) on magnesium gluconate for the change in the structural properties and isotopic abundance ratio (PM+1/PM and PM+2/PM) using LC-MS and NMR spectroscopy. Magnesium gluconate was divided into two parts – one part was control, and another part was treated with The Trivedi Effect® - Biofield

APA, Harvard, Vancouver, ISO, and other styles

45

Holmlund, Shirley Theresa, Mahendra Kumar Trivedi, Gopal Nayak, Alice Branton, and Dahryn Trivedi. "Structural and Natural Isotopic Abundance Analysis of Magnesium Gluconate Treated with Energy of Consciousness (The Trivedi Effect®) Using LC-MS and NMR." Chemical and Biomolecular Engineering 2, no. 3 (2017): 124–34. https://doi.org/10.5281/zenodo.852255.

Full text

Abstract:

The current research article was aimed to investigate the impact of The Trivedi Effect®- Energy of Consciousness Healing Treatment on the structural properties and isotopic abundance ratio (PM+1/PM and PM+2/PM) of magnesium gluconate using LC-MS and NMR spectroscopy. Magnesium gluconate was divided into two parts – one part was control, and another part was treated with The Trivedi Effect® remotely by eighteen renowned Biofield Energy Healers and defined as the Trivedi Effect® Treated sample. The liquid chromatogram of the control sample showed two peaks at Rt of 1.81 and 2.06 min, whereas the

APA, Harvard, Vancouver, ISO, and other styles

46

Muskatel, Rakefet Sidlik, Bar Nathansohn-Levi, Esther BACHAR Lustig, and Yair Reisner. "Towards Safer Allogeneic HSCT in Autoimmunity: Proof of Concept in Diabetes-Prone Mice." Blood 134, Supplement_1 (2019): 3212. http://dx.doi.org/10.1182/blood-2019-124905.

Full text

Abstract:

R.S.K and B.N.L contributed equally to this study. The induction of tolerance towards pancreas autoantigens is a promising approach in the treatment of type 1 diabetes mellitus (T1DM). This goal can be partially attained by immuno-ablation followed by autologous HSCT which mitigates the immune reaction leading to diabetes, at least temporarily, if performed soon after diagnosis. However, most T1DM patients transplanted with autologous HSCT eventually relapse (E Snarski et al., Bone marrow Transplantation; 2016; 51, 398-402). Thus, developing methodologies for allogeneic HSCT, to provide a dura

APA, Harvard, Vancouver, ISO, and other styles

47

Paul, Sudip Kumar, Masamitsu Sone, Hisaya Kato, et al. "Disease Model of Atherosclerosis Using Werner Syndrome Patient-Derived Induced Pluripotent Stem Cells Reveals Excessive Inflammatory Response Against Ox-LDL." Blood 134, Supplement_1 (2019): 3615. http://dx.doi.org/10.1182/blood-2019-123919.

Full text

Abstract:

Atherosclerosis is a major cause of various fatal diseases, such as myocardial infarction, stroke, and ischemic heart failure worldwide. The risk factors of atherosclerosis are well known, including hypertension, diabetes mellitus, dyslipidemia, smoking and obesity. Growing evidence also suggests that aging is the strongest determinant of stroke, which is less common before 40 years old (Soler and Ruiz 2010). Werner syndrome (WS) is a rare human inherited disorder characterized by the appearance of premature aging followed by early onset of aging-associated diseases including atherosclerosis.

APA, Harvard, Vancouver, ISO, and other styles

48

Dilworth, Lowell, Dewayne Stennett, and Felix Omoruyi. "Cellular and Molecular Activities of IP6 in Disease Prevention and Therapy." Biomolecules 13, no. 6 (2023): 972. http://dx.doi.org/10.3390/biom13060972.

Full text

Abstract:

IP6 (phytic acid) is a naturally occurring compound in plant seeds and grains. It is a poly-phosphorylated inositol derivative that has been shown to exhibit many biological activities that accrue benefits in health and diseases (cancer, diabetes, renal lithiasis, cardiovascular diseases, etc.). IP6 has been shown to have several cellular and molecular activities associated with its potential role in disease prevention. These activities include anti-oxidant properties, chelation of metal ions, inhibition of inflammation, modulation of cell signaling pathways, and modulation of the activities o

APA, Harvard, Vancouver, ISO, and other styles

49

Sucker, Christoph, Rainer B. Zotz, Rudiger E. Scharf, and Andrea Gerhardt. "Acquired Hemophilia: Single Center Experience with a Standardized Approach." Blood 106, no. 11 (2005): 4059. http://dx.doi.org/10.1182/blood.v106.11.4059.4059.

Full text

Abstract:

Abstract Background: Acquired hemophilia is a rare, often life-threatening, bleeding diathesis caused by autoantibodies, most commonly directed against factor VIII:C. Several clinical studies have reported mortality rates of 16–22 % for affected patients depending on age, inhibitor titre levels, and individual response to treatment. Patients in whom the inhibitor could not be eliminated had a mortality rate of 42 %, providing a strong argument for the necessity of rapid and long-term inhibitor elimination as part of the therapeutic concept. To date, no general consensus exists on the best ther

APA, Harvard, Vancouver, ISO, and other styles

50

Pujala, Shivakrishna, and Mamidala Estari. "Exploring the multi-targeted therapeutic potential of Benzoquinoline in diabetes: A molecular docking study with key enzymes." Eur. Chem. Bull 12, no. 06 (2023): 4753–64. https://doi.org/10.5281/zenodo.8037647.

Full text

Abstract:

<strong>ABSTRACT</strong> Diabetes mellitus is a chronic metabolic disorder affecting millions of people worldwide. Developing effective therapeutic interventions for diabetes requires a comprehensive understanding of the molecular interactions between potential drug candidates and key enzymes involved in the disease pathways. In this study, we investigated the multi-targeted therapeutic potential of Benzoquinoline, a promising small molecule, in diabetes treatment. Using molecular docking simulations, we explored the binding interactions of Benzoquinoline with key enzymes implicated in diabet

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!