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Journal articles on the topic 'Therapeutic Responses Against Diseases'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Das, Palamou, and Oishee Chakrabarti. "Mitochondrial DNA in innate immune responses against infectious diseases." Biochemical Society Transactions 48, no. 6 (2020): 2823–38. http://dx.doi.org/10.1042/bst20200687.

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Mitochondrial DNA (mtDNA) can initiate an innate immune response when mislocalized in a compartment other than the mitochondrial matrix. mtDNA plays significant roles in regulating mitochondrial dynamics as well as mitochondrial unfolded protein response (UPR). The mislocalized extra-mtDNA can elicit innate immune response via cGAS–STING (cyclic GMP-AMP synthase–stimulator of interferon genes) pathway, inducing the expression of the interferon-stimulated genes (ISGs). Also, cytosolic damaged mtDNA is cleared up by various pathways which are responsible for participating in the activation of in

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2

Schnitzer, Debra Jane, Mahendra Kumar Trivedi, Gopal Nayak, Alice Branton, and Dahryn Trivedi. "Investigation of Physicochemical, Spectral, and Thermal Properties of Sodium Selenate Treated with the Energy of Consciousness (The Trivedi Effect®)." American Journal of Life Sciences 5, no. 1 (2017): 27–37. https://doi.org/10.5281/zenodo.835625.

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Sodium selenate is used for the prevention and treatment of various disorders like cancer, diabetes, inflammation diseases, etc. The objective of the current study was to evaluate the effect of The Trivedi Effect®-Energy of Consciousness Healing Treatment (Biofield Energy Treatment) on physicochemical, spectral, and thermal properties of The Trivedi Effect®-Biofield Energy Treated sodium selenate using various analytical methods such as PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Sodium selenate was divided into two parts – one part was control without any treatment and anoth

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3

Olajiga, Olayinka, Andrés F. Holguin-Rocha, Meagan Rippee-Brooks, Megan Eppler, Shanice L. Harris, and Berlin Londono-Renteria. "Vertebrate Responses against Arthropod Salivary Proteins and Their Therapeutic Potential." Vaccines 9, no. 4 (2021): 347. http://dx.doi.org/10.3390/vaccines9040347.

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The saliva of hematophagous arthropods contains a group of active proteins to counteract host responses against injury and to facilitate the success of a bloodmeal. These salivary proteins have significant impacts on modulating pathogen transmission, immunogenicity expression, the establishment of infection, and even disease severity. Recent studies have shown that several salivary proteins are immunogenic and antibodies against them may block infection, thereby suggesting potential vaccine candidates. Here, we discuss the most relevant salivary proteins currently studied for their therapeutic

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4

Bouche, Gauthier, Liese Vandeborne, Pan Pantziarka, and An M. T. Van Nuffel. "Repurposing infectious diseases vaccines against cancer." Journal of Clinical Oncology 39, no. 15_suppl (2021): e14564-e14564. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e14564.

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e14564 Background: Vaccines used to prevent infection have long been known to stimulate immune responses to cancer as illustrated by the approval of the Bacillus Calmette–Guérin (BCG) vaccine to treat bladder cancer since the 1970s. The recent approval of immunotherapies has rejuvenated this research area with reports of anti-tumour responses with existing infectious diseases vaccines used as such, either alone or in combination with approved immune checkpoint inhibitors. This prompted us to review recent research activities using approved vaccines to treat cancer. Methods: PubMed and clinical

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Jung, Hi Eun, and Heung Kyu Lee. "Host Protective Immune Responses against Influenza A Virus Infection." Viruses 12, no. 5 (2020): 504. http://dx.doi.org/10.3390/v12050504.

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Influenza viruses cause infectious respiratory disease characterized by fever, myalgia, and congestion, ranging in severity from mild to life-threating. Although enormous efforts have aimed to prevent and treat influenza infections, seasonal and pandemic influenza outbreaks remain a major public health concern. This is largely because influenza viruses rapidly undergo genetic mutations that restrict the long-lasting efficacy of vaccine-induced immune responses and therapeutic regimens. In this review, we discuss the virological features of influenza A viruses and provide an overview of current

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Galindo-Izquierdo, María, and José Luis Pablos Alvarez. "Complement as a Therapeutic Target in Systemic Autoimmune Diseases." Cells 10, no. 1 (2021): 148. http://dx.doi.org/10.3390/cells10010148.

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The complement system (CS) includes more than 50 proteins and its main function is to recognize and protect against foreign or damaged molecular components. Other homeostatic functions of CS are the elimination of apoptotic debris, neurological development, and the control of adaptive immune responses. Pathological activation plays prominent roles in the pathogenesis of most autoimmune diseases such as systemic lupus erythematosus, antiphospholipid syndrome, rheumatoid arthritis, dermatomyositis, and ANCA-associated vasculitis. In this review, we will review the main rheumatologic autoimmune p

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D'Elia, Riccardo V., Kate Harrison, Petra C. Oyston, Roman A. Lukaszewski, and Graeme C. Clark. "Targeting the “Cytokine Storm” for Therapeutic Benefit." Clinical and Vaccine Immunology 20, no. 3 (2013): 319–27. http://dx.doi.org/10.1128/cvi.00636-12.

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ABSTRACTInflammation is the body's first line of defense against infection or injury, responding to challenges by activating innate and adaptive responses. Microbes have evolved a diverse range of strategies to avoid triggering inflammatory responses. However, some pathogens, such as the influenza virus and the Gram-negative bacteriumFrancisella tularensis, do trigger life-threatening “cytokine storms” in the host which can result in significant pathology and ultimately death. For these diseases, it has been proposed that downregulating inflammatory immune responses may improve outcome. We rev

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Salters, Stephen P., Mahendra Kumar Trivedi, Gopal Nayak, Alice Branton, and Dahryn Trivedi. "Investigation of Physicochemical, Spectral, and Thermal Properties of Sodium Selenate Treated with the Energy of Consciousness (The Trivedi Effect®)." American Journal of Life Sciences 5, no. 1 (2017): 27–37. https://doi.org/10.5281/zenodo.853132.

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Sodium selenate is used for the prevention and treatment of various disorders like cancer, diabetes, inflammation diseases, etc. The objective of the current study was to evaluate the effect of The Trivedi Effect®-Energy of Consciousness Healing Treatment (Biofield Energy Treatment) on physicochemical, spectral, and thermal properties of The Trivedi Effect®-Biofield Energy Treated sodium selenate using various analytical methods such as PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Sodium selenate was divided into two parts – one part was control without any treatment and anoth

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9

Sohrab, Sayed Sartaj, Sherif Aly El-Kafrawy, Zeenat Mirza, Mohammad Amjad Kamal, and Esam Ibraheem Azhar. "Design and Delivery of Therapeutic siRNAs: Application to MERS-Coronavirus." Current Pharmaceutical Design 24, no. 1 (2018): 62–77. http://dx.doi.org/10.2174/1381612823666171109112307.

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Background: The MERS-CoV is a novel human coronavirus causing respiratory syndrome since April 2012. The replication of MERS-CoV is mediated by ORF 1ab and viral gene activity can be modulated by RNAi approach. The inhibition of virus replication has been documented in cell culture against multiple viruses by RNAi approach. Currently, very few siRNA against MERS-CoV have been computationally designed and published. Methods: In this review, we have discussed the computational designing and delivery of potential siRNAs. Potential siRNA can be designed to silence a desired gene by considering man

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10

Jung, Hi Eun, and Heung Kyu Lee. "Current Understanding of the Innate Control of Toll-like Receptors in Response to SARS-CoV-2 Infection." Viruses 13, no. 11 (2021): 2132. http://dx.doi.org/10.3390/v13112132.

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The global coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection, threatens the entire world. It has affected every aspect of life and increased the burden on both healthcare and socioeconomic systems. Current studies have revealed that excessive inflammatory immune responses are responsible for the severity of COVID-19, which suggests that anti-inflammatory drugs may be promising therapeutic treatments. However, there are currently a limited number of approved therapeutics for COVID-19. Toll-like receptors (TLRs), which

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Mattson, Mark P., Tae Gen Son, and Simonetta Camandola. "Viewpoint: Mechanisms of Action and Therapeutic Potential of Neurohormetic Phytochemicals." Dose-Response 5, no. 3 (2007): dose—response.0. http://dx.doi.org/10.2203/dose-response.07-004.mattson.

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The nervous system is of fundamental importance in the adaptive (hormesis) responses of organisms to all types of stress, including environmental “toxins”. Phytochemicals present in vegetables and fruits are believed to reduce the risk of several major diseases including cardiovascular disease, cancers and neurodegenerative disorders. Although antioxidant properties have been suggested as the basis of health benefits of phytochemicals, emerging findings suggest a quite different mechanism of action. Many phytochemicals normally function as toxins that protect the plants against insects and oth

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Banesh, Sooram, and Vishal Trivedi. "Therapeutic Potentials of Scavenger Receptor CD36 Mediated Innate Immune Responses Against Infectious and Non-Infectious Diseases." Current Drug Discovery Technologies 17, no. 3 (2020): 299–317. http://dx.doi.org/10.2174/1570163816666190802153319.

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CD36 is a multifunctional glycoprotein, expressed in different types of cells and known to play a significant role in the pathophysiology of the host. The structural studies revealed that the scavenger receptor consists of short cytosolic domains, two transmembrane domains, and a large ectodomain. The ectodomain serves as a receptor for a diverse number of endogenous and exogenous ligands. The CD36-specific ligands are involved in regulating the immune response during infectious and non-infectious diseases in the host. The role of CD36 in regulating the innate immune response during Pneumonia,

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Hornung, Matthew Charles, Mahendra Kumar Trivedi, Gopal Nayak, Alice Branton, and Dahryn Trivedi. "Investigation of Physicochemical, Spectral, and Thermal Properties of Sodium Selenate Treated with the Energy of Consciousness (The Trivedi Effect®)." American Journal of Life Sciences 5, no. 1 (2017): 27–37. https://doi.org/10.5281/zenodo.844584.

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Sodium selenate is used for the prevention and treatment of various disorders like cancer, diabetes, inflammation diseases, etc. The objective of the current study was to evaluate the effect of The Trivedi Effect®-Energy of Consciousness Healing Treatment (Biofield Energy Treatment) on physicochemical, spectral, and thermal properties of The Trivedi Effect®-Biofield Energy Treated sodium selenate using various analytical methods such as PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Sodium selenate was divided into two parts – one part was control without any treatment and anoth

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Griffin, John Lawrence, Mahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi, and Gopal Nayak. "Effect of the Energy of Consciousness (The Trivedi Effect®) on Physicochemical, Thermal, Structural, and Behavioral Properties of Magnesium Gluconate." Chemical and Biomolecular Engineering 2, no. 2 (2017): 113–23. https://doi.org/10.5281/zenodo.884138.

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Magnesium gluconate is an organometallic pharmaceutical compound used for the prevention and treatment of hypomagnesemia. The objective of the current research work was to examine the influence of The Trivedi Effect®-Energy of Consciousness Healing Treatment (Biofield Energy Treatment) on magnesium gluconate for the alteration in the physicochemical, structural, thermal and behavioral properties using PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Magnesium gluconate was divided into two parts – one part was control without any Biofield Energy Treatment, while another part was t

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Vidhyalakshmi R, Rajaganapathy K, Kowsika M, and Pratheeba G. "The Transformative Potential of mRNA Vaccines in Revolutionizing Vaccine Development And Therapeutic Applications." Journal of Pharma Insights and Research 2, no. 3 (2024): 080–87. http://dx.doi.org/10.69613/vpxx7e92.

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Messenger RNA (mRNA) technology has emerged as a transformative force in the field of vaccine development and therapeutic applications, revolutionizing the landscape of modern medicine. This cutting-edge technology enables the rapid and flexible design of vaccines and therapeutics, unleashing a new era of personalized and targeted treatments. During the COVID-19 pandemic, mRNA vaccines demonstrated their immense potential by facilitating the swift development and deployment of highly effective vaccines against SARS-CoV-2, contributing significantly to the global response against the virus. Bey

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Cho, Minkyoung, and Hak Sun Yu. "Therapeutic potentials of Trichinella spiralis in immune disorders: From allergy to autoimmunity." Parasites, Hosts and Diseases 63, no. 2 (2025): 123–34. https://doi.org/10.3347/phd.24086.

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The incidence of immune system diseases is increasing globally, particularly in developed countries. The hygiene and old friend hypotheses suggest that the decreased incidence of helminth infections in these countries may underlie the rising prevalence of autoimmune, allergic, and inflammatory diseases. The preventive and therapeutic potential of Trichinella spiralis, a helminthic parasite, has been well demonstrated in animal models of immune dysregulation-mediated diseases. This review comprehensively analyze how T. spiralis modulates immune responses across a spectrum of immune dysregulatio

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Lee, Aileen Carol, Mahendra Kumar Trivedi, Gopal Nayak, Alice Branton, and Dahryn Trivedi. "Investigation of Physicochemical, Spectral, and Thermal Properties of Sodium Selenate Treated with the Energy of Consciousness (The Trivedi Effect®)." American Journal of Life Sciences 5, no. 1 (2017): 27–37. https://doi.org/10.5281/zenodo.823193.

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Sodium selenate is used for the prevention and treatment of various disorders like cancer, diabetes, inflammation diseases, etc. The objective of the current study was to evaluate the effect of The Trivedi Effect®-Energy of Consciousness Healing Treatment (Biofield Energy Treatment) on physicochemical, spectral, and thermal properties of The Trivedi Effect®-Biofield Energy Treated sodium selenate using various analytical methods such as PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Sodium selenate was divided into two parts – one part was control without any treatment and anoth

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18

La Manna, Sara, Concetta Di Natale, Daniele Florio, and Daniela Marasco. "Peptides as Therapeutic Agents for Inflammatory-Related Diseases." International Journal of Molecular Sciences 19, no. 9 (2018): 2714. http://dx.doi.org/10.3390/ijms19092714.

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Inflammation is a physiological mechanism used by organisms to defend themselves against infection, restoring homeostasis in damaged tissues. It represents the starting point of several chronic diseases such as asthma, skin disorders, cancer, cardiovascular syndrome, arthritis, and neurological diseases. An increasing number of studies highlight the over-expression of inflammatory molecules such as oxidants, cytokines, chemokines, matrix metalloproteinases, and transcription factors into damaged tissues. The treatment of inflammatory disorders is usually linked to the use of unspecific small m

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Hu, Wanbin, and Herman P. Spaink. "The Role of TLR2 in Infectious Diseases Caused by Mycobacteria: From Cell Biology to Therapeutic Target." Biology 11, no. 2 (2022): 246. http://dx.doi.org/10.3390/biology11020246.

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Innate immunity is considered the first line of defense against microbial invasion, and its dysregulation can increase the susceptibility of hosts to infections by invading pathogens. Host cells rely on pattern recognition receptors (PRRs) to recognize invading pathogens and initiate protective innate immune responses. Toll-like receptor 2 (TLR2) is believed to be among the most important Toll-like receptors for defense against mycobacterial infection. TLR2 has been reported to have very broad functions in infectious diseases and also in other diseases, such as chronic and acute inflammatory d

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Vallières, Cindy, Marie-Pierre Golinelli-Cohen, Olivier Guittet, Michel Lepoivre, Meng-Er Huang, and Laurence Vernis. "Redox-Based Strategies against Infections by Eukaryotic Pathogens." Genes 14, no. 4 (2023): 778. http://dx.doi.org/10.3390/genes14040778.

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Redox homeostasis is an equilibrium between reducing and oxidizing reactions within cells. It is an essential, dynamic process, which allows proper cellular reactions and regulates biological responses. Unbalanced redox homeostasis is the hallmark of many diseases, including cancer or inflammatory responses, and can eventually lead to cell death. Specifically, disrupting redox balance, essentially by increasing pro-oxidative molecules and favouring hyperoxidation, is a smart strategy to eliminate cells and has been used for cancer treatment, for example. Selectivity between cancer and normal c

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Fu, Hua-Wen, and Yu-Chang Lai. "The Role of Helicobacter pylori Neutrophil-Activating Protein in the Pathogenesis of H. pylori and Beyond: From a Virulence Factor to Therapeutic Targets and Therapeutic Agents." International Journal of Molecular Sciences 24, no. 1 (2022): 91. http://dx.doi.org/10.3390/ijms24010091.

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Helicobacter pylori neutrophil-activating protein (HP-NAP), a major virulence factor of H. pylori, plays a role in bacterial protection and host inflammation. HP-NAP activates a variety of innate immune cells, including neutrophils, monocytes, and mast cells, to induce their pro-oxidant and pro-inflammatory activities. This protein also induces T-helper type 1 (Th1) immune response and cytotoxic T lymphocyte (CTL) activity, supporting that HP-NAP is able to promote gastric inflammation by activation of adaptive immune responses. Thus, HP-NAP is a potential therapeutic target for the treatment

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Paudel, Pradeep, Su Hui Seong, Sangwook Wu, Suhyun Park, Hyun Ah Jung, and Jae Sue Choi. "Eckol as a Potential Therapeutic against Neurodegenerative Diseases Targeting Dopamine D3/D4 Receptors." Marine Drugs 17, no. 2 (2019): 108. http://dx.doi.org/10.3390/md17020108.

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The G protein-coupled receptor (GPCR) family of proteins comprises signaling proteins that mediate cellular responses to various hormones and neurotransmitters, and serves as a prime target for drug discovery. Towards our goal of discovering secondary metabolites from natural sources that can function as neuronal drugs, we evaluated the modulatory effect of eckol on various GPCRs via cell-based functional assays. In addition, we conducted in silico predictions to obtain molecular insights into the functional effects of eckol. Functional assays revealed that eckol had a concentration-dependent

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Rahman, MS, ML Hakim, UK Rima, MM Rahman, and NA Rumi. "Prevalence of diseases of pigeons and responses to treatment of bacterial disease." Bangladesh Veterinarian 37, no. 1-2 (2022): 21–26. http://dx.doi.org/10.3329/bvet.v37i1-2.59283.

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The prevalence of diseases of pigeon and response to treatment of bacterial disease were studied. One thousand pigeons were collected and examined to diagnose diseases following clinical history and signs, post-mortem lesions and laboratory examination. The overall prevalence of pigeon diseases was 21.9% (n = 219). Parasitic infestation was significantly (P<0.01) higher (30%) followed by bacterial (22.3%), viral (18.9%) nutritional and others (16.3%) and fungal (14.3%). Disease prevalence was higher in female than in male, and higher in birds of 2 to 6-months old than in older or younger bi

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Combadière, Beaujean, Chaudesaigues, and Vieillard. "Peptide-Based Vaccination for Antibody Responses Against HIV." Vaccines 7, no. 3 (2019): 105. http://dx.doi.org/10.3390/vaccines7030105.

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HIV-1 is responsible for a global pandemic of 35 million people and continues to spread at a rate of >2 million new infections/year. It is widely acknowledged that a protective vaccine would be the most effective means to reduce HIV-1 spread and ultimately eliminate the pandemic, whereas a therapeutic vaccine might help to mitigate the clinical course of the disease and to contribute to virus eradication strategies. However, despite more than 30 years of research, we do not have a vaccine capable of protecting against HIV-1 infection or impacting on disease progression. This, in part, denot

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Chow, Stephanie, Jonathan S. Berek, and Oliver Dorigo. "Development of Therapeutic Vaccines for Ovarian Cancer." Vaccines 8, no. 4 (2020): 657. http://dx.doi.org/10.3390/vaccines8040657.

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Ovarian cancer remains the deadliest of all gynecologic malignancies. Our expanding knowledge of ovarian cancer immunology has allowed the development of therapies that generate systemic anti-tumor immune responses. Current immunotherapeutic strategies include immune checkpoint blockade, cellular therapies, and cancer vaccines. Vaccine-based therapies are designed to induce both adaptive and innate immune responses directed against ovarian cancer associated antigens. Tumor-specific effector cells, in particular cytotoxic T cells, are activated to recognize and eliminate ovarian cancer cells. V

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Nur Husna, Siti Muhamad, Norasnieda Md Shukri, Noor Suryani Mohd Ashari, and Kah Keng Wong. "IL-4/IL-13 axis as therapeutic targets in allergic rhinitis and asthma." PeerJ 10 (May 30, 2022): e13444. http://dx.doi.org/10.7717/peerj.13444.

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Allergic rhinitis (AR) is a common disorder of the upper airway, while asthma is a disease affecting the lower airway and both diseases are usually comorbid. Interleukin (IL)-4 and IL-13 are critical cytokines in the induction of the pathogenic Th2 responses in AR and asthma. Targeting the IL-4/IL-13 axis at various levels of its signaling pathway has emerged as promising targeted therapy in both AR and asthma patient populations. In this review, we discuss the biological characteristics of IL-4 and IL-13, their signaling pathways, and therapeutic antibodies against each cytokine as well as th

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Lundstrom, Kenneth. "Self-Replicating Alphaviruses: From Pathogens to Therapeutic Agents." Viruses 16, no. 11 (2024): 1762. http://dx.doi.org/10.3390/v16111762.

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Alphaviruses are known for being model viruses for studying cellular functions related to viral infections but also for causing epidemics in different parts of the world. More recently, alphavirus-based expression systems have demonstrated efficacy as vaccines against infectious diseases and as therapeutic applications for different cancers. Point mutations in the non-structural alphaviral replicase genes have generated enhanced transgene expression and created temperature-sensitive expression vectors. The recently engineered trans-amplifying RNA system can provide higher translational efficie

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Kowalewicz-Kulbat, Magdalena, and Camille Locht. "Recombinant BCG to Enhance Its Immunomodulatory Activities." Vaccines 10, no. 5 (2022): 827. http://dx.doi.org/10.3390/vaccines10050827.

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The bacillus Calmette–Guérin (BCG) is an attenuated Mycobacterium bovis derivative that has been widely used as a live vaccine against tuberculosis for a century. In addition to its use as a tuberculosis vaccine, BCG has also been found to have utility in the prevention or treatment of unrelated diseases, including cancer. However, the protective and therapeutic efficacy of BCG against tuberculosis and other diseases is not perfect. For three decades, it has been possible to genetically modify BCG in an attempt to improve its efficacy. Various immune-modulatory molecules have been produced in

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Senapati, Sujata, Ross J. Darling, Kathleen A. Ross, Michael J. Wannemeuhler, Balaji Narasimhan, and Surya K. Mallapragada. "Self-assembling synthetic nanoadjuvant scaffolds cross-link B cell receptors and represent new platform technology for therapeutic antibody production." Science Advances 7, no. 32 (2021): eabj1691. http://dx.doi.org/10.1126/sciadv.abj1691.

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Host antibody responses are pivotal for providing protection against infectious agents. We have pioneered a new class of self-assembling micelles based on pentablock copolymers that enhance antibody responses while providing a low inflammatory environment compared to traditional adjuvants. This type of “just-right” immune response is critical in the rational design of vaccines for older adults. Here, we report on the mechanism of enhancement of antibody responses by pentablock copolymer micelles, which act as scaffolds for antigen presentation to B cells and cross-link B cell receptors, unlike

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Taghinezhad-S, Sedigheh, Amir Hossein Mohseni, Luis G. Bermúdez-Humarán, et al. "Probiotic-Based Vaccines May Provide Effective Protection against COVID-19 Acute Respiratory Disease." Vaccines 9, no. 5 (2021): 466. http://dx.doi.org/10.3390/vaccines9050466.

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Severe acute respiratory syndrome coronavirus 2 virus (SARS-CoV-2) infection, the causative agent of COVID-19, now represents the sixth Public Health Emergency of International Concern (PHEIC)—as declared by the World Health Organization (WHO) since 2009. Considering that SARS-CoV-2 is mainly transmitted via the mucosal route, a therapy administered by this same route may represent a desirable approach to fight SARS-CoV-2 infection. It is now widely accepted that genetically modified microorganisms, including probiotics, represent attractive vehicles for oral or nasal mucosal delivery of thera

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Severo, Juliana Soares, Alda Cássia Alves da Silva, Brenda Lois Barros dos Santos, et al. "Physical Exercise as a Therapeutic Approach in Gastrointestinal Diseases." Journal of Clinical Medicine 14, no. 5 (2025): 1708. https://doi.org/10.3390/jcm14051708.

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Background/Objectives: Physical exercise can have significant consequences for the gastrointestinal tract, which is why there have been studies into its influence on the treatment of conditions such as colorectal cancer, inflammatory bowel diseases (IBD), and irritable bowel syndrome (IBS), being that there is epidemiological evidence that exercise has a protective effect against colon cancer. This review aims to demonstrate the mechanisms of action of physical exercise in the gastrointestinal tract, as well as the benefits of exercise in diseases associated with the digestive system, in addit

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Lérias, Joana R., Georgia Paraschoudi, Inês Silva, et al. "Clinically Relevant Immune Responses against Cytomegalovirus: Implications for Precision Medicine." International Journal of Molecular Sciences 20, no. 8 (2019): 1986. http://dx.doi.org/10.3390/ijms20081986.

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Immune responses to human cytomegalovirus (CMV) can be used to assess immune fitness in an individual. Further to its clinical significance in posttransplantation settings, emerging clinical and translational studies provide examples of immune correlates of protection pertaining to anti-CMV immune responses in the context of cancer or infectious diseases, e.g., tuberculosis. In this viewpoint, we provide a brief overview about CMV-directed immune reactivity and immune fitness in a clinical context and incorporate some of our own findings obtained from peripheral blood or tumour-infiltrating ly

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Knolle, Percy A., Li-Rung Huang, Anna Kosinska, Dirk Wohlleber, and Ulrike Protzer. "Improving Therapeutic Vaccination against Hepatitis B—Insights from Preclinical Models of Immune Therapy against Persistent Hepatitis B Virus Infection." Vaccines 9, no. 11 (2021): 1333. http://dx.doi.org/10.3390/vaccines9111333.

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Chronic hepatitis B affects more than 250 million individuals worldwide, putting them at risk of developing liver cirrhosis and liver cancer. While antiviral immune responses are key to eliminating hepatitis B virus (HBV) infections, insufficient antiviral immunity characterized by failure to eliminate HBV-infected hepatocytes is associated with chronic hepatitis B. Prophylactic vaccination against hepatitis B successfully established protective immunity against infection with the hepatitis B virus and has been instrumental in controlling hepatitis B. However, prophylactic vaccination schemes

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Mieres-Castro, Daniel, Sunny Ahmar, Rubab Shabbir, and Freddy Mora-Poblete. "Antiviral Activities of Eucalyptus Essential Oils: Their Effectiveness as Therapeutic Targets against Human Viruses." Pharmaceuticals 14, no. 12 (2021): 1210. http://dx.doi.org/10.3390/ph14121210.

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Given the limited therapeutic management of infectious diseases caused by viruses, such as influenza and SARS-CoV-2, the medicinal use of essential oils obtained from Eucalyptus trees has emerged as an antiviral alternative, either as a complement to the treatment of symptoms caused by infection or to exert effects on possible pharmacological targets of viruses. This review gathers and discusses the main findings on the emerging role and effectiveness of Eucalyptus essential oil as an antiviral agent. Studies have shown that Eucalyptus essential oil and its major monoterpenes have enormous pot

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Salters, Stephen P., Mahendra Kumar Trivedi, Gopal Nayak, Alice Branton, and Dahryn Trivedi. "A Comprehensive Analytical Evaluation of the Trivedi Effect® - Energy of Consciousness Healing Treatment on the Physical, Structural, and Thermal Properties of Zinc Chloride." American Journal of Applied Chemistry 5, no. 1 (2017): 7–18. https://doi.org/10.5281/zenodo.853128.

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Zinc chloride has an importance in pharmaceutical and nutraceutical industries for the prevention and treatment of several diseases. The objective of the current study was to investigate the impact of The Trivedi Effect® – Energy of Consciousness Healing Treatment (Biofield Energy Treatment) on physical, structural, and thermal properties of zinc chloride using PXRD, PSD, FT-IR, UV-vis, TGA, and DSC analysis. Zinc chloride was divided into two parts – one part was control, while other part was treated with The Trivedi Effect® remotely by eighteen renowned Biofield Energy Healers and defined as

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Matsuzaka, Yasunari, and Ryu Yashiro. "Regulation of Extracellular Vesicle-Mediated Immune Responses against Antigen-Specific Presentation." Vaccines 10, no. 10 (2022): 1691. http://dx.doi.org/10.3390/vaccines10101691.

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Extracellular vesicles (EVs) produced by various immune cells, including B and T cells, macrophages, dendritic cells (DCs), natural killer (NK) cells, and mast cells, mediate intercellular communication and have attracted much attention owing to the novel delivery system of molecules in vivo. DCs are among the most active exosome-secreting cells of the immune system. EVs produced by cancer cells contain cancer antigens; therefore, the development of vaccine therapy that does not require the identification of cancer antigens using cancer-cell-derived EVs may have significant clinical implicatio

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Chauhan, Jitesh, Alex J. McCraw, Mano Nakamura, et al. "IgE Antibodies against Cancer: Efficacy and Safety." Antibodies 9, no. 4 (2020): 55. http://dx.doi.org/10.3390/antib9040055.

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Immunoglobulin E (IgE) antibodies are well known for their role in allergic diseases and for contributions to antiparasitic immune responses. Properties of this antibody class that mediate powerful effector functions may be redirected for the treatment of solid tumours. This has led to the rise of a new class of therapeutic antibodies to complement the armamentarium of approved tumour targeting antibodies, which to date are all IgG class. The perceived risk of type I hypersensitivity reactions following administration of IgE has necessitated particular consideration in the development of these

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Khan, Imran Ahmad, Musaddique Hussain, Nadia Hussain, Ali M. Alqahtani, and Taha Alqahtani. "Cardioprotective Effect of Rumex vesicarius Linn. Leaf Extract against Catecholamine-Induced Cardiotoxicity." Molecules 27, no. 11 (2022): 3383. http://dx.doi.org/10.3390/molecules27113383.

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Rumex vesicarius (L.) is a folklore medicinal herb that has been used for centuries to cure cardiovascular diseases. The present work was carefully designed to ascertain the pharmacological basis for R. vesicarius’s therapeutic efficacy in cardiovascular diseases, as well as the underlying mechanism. In the ex vivo investigation, the aqueous-methanolic leaf extract of R. vesicarius was shown to have endothelium-dependent vasorelaxant effects in rabbit aorta tissue preparations, and its hypotensive responses were quantified by pressure and force transducers coupled to the Power Lab Data Acquisi

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Lyly, Annina, Anu Laulajainen-Hongisto, Philippe Gevaert, Paula Kauppi, and Sanna Toppila-Salmi. "Monoclonal Antibodies and Airway Diseases." International Journal of Molecular Sciences 21, no. 24 (2020): 9477. http://dx.doi.org/10.3390/ijms21249477.

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Monoclonal antibodies, biologics, are a relatively new treatment option for severe chronic airway diseases, asthma, allergic rhinitis, and chronic rhinosinusitis (CRS). In this review, we focus on the physiological and pathomechanisms of monoclonal antibodies, and we present recent study results regarding their use as a therapeutic option against severe airway diseases. Airway mucosa acts as a relative barrier, modulating antigenic stimulation and responding to environmental pathogen exposure with a specific, self-limited response. In severe asthma and/or CRS, genome–environmental interactions

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Kayesh, Mohammad, Md Hashem, and Kyoko Tsukiyama-Kohara. "Toll-Like Receptor and Cytokine Responses to Infection with Endogenous and Exogenous Koala Retrovirus, and Vaccination as a Control Strategy." Current Issues in Molecular Biology 43, no. 1 (2021): 52–64. http://dx.doi.org/10.3390/cimb43010005.

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Koala populations are currently declining and under threat from koala retrovirus (KoRV) infection both in the wild and in captivity. KoRV is assumed to cause immunosuppression and neoplastic diseases, favoring chlamydiosis in koalas. Currently, 10 KoRV subtypes have been identified, including an endogenous subtype (KoRV-A) and nine exogenous subtypes (KoRV-B to KoRV-J). The host’s immune response acts as a safeguard against pathogens. Therefore, a proper understanding of the immune response mechanisms against infection is of great importance for the host’s survival, as well as for the developm

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Shapiro, Judith Marian, Mahendra Kumar Trivedi, Gopal Nayak, Alice Branton, and Dahryn Trivedi. "Investigation of Physicochemical, Spectral, and Thermal Properties of Sodium Selenate Treated with the Energy of Consciousness (The Trivedi Effect®)." American Journal of Life Sciences 5, no. 1 (2017): 27–37. https://doi.org/10.5281/zenodo.841068.

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Sodium selenate is used for the prevention and treatment of various disorders like cancer, diabetes, inflammation diseases, etc. The objective of the current study was to evaluate the effect of The Trivedi Effect®-Energy of Consciousness Healing Treatment (Biofield Energy Treatment) on physicochemical, spectral, and thermal properties of The Trivedi Effect®-Biofield Energy Treated sodium selenate using various analytical methods such as PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Sodium selenate was divided into two parts – one part was control without any treatment and anoth

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Zheng, Miao-Yan, and Lian-Zhong Luo. "The Role of IL-17A in Mediating Inflammatory Responses and Progression of Neurodegenerative Diseases." International Journal of Molecular Sciences 26, no. 6 (2025): 2505. https://doi.org/10.3390/ijms26062505.

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IL-17A has been implicated as a critical pro-inflammatory cytokine in the pathogenesis of autoimmune and neurodegenerative disorders. Emerging evidence indicates its capacity to activate microglial cells and astrocytes, subsequently inducing the production of inflammatory mediators that exacerbate neuronal injury and functional impairment. Clinical observations have revealed a demonstrated association between IL-17A concentrations and blood–brain barrier (BBB) dysfunction, creating a pathological feedback loop that amplifies neuro-inflammatory responses. Recent advances highlight the cytokine’

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Balke, Ina, and Andris Zeltins. "Recent Advances in the Use of Plant Virus-Like Particles as Vaccines." Viruses 12, no. 3 (2020): 270. http://dx.doi.org/10.3390/v12030270.

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Vaccination is one of the most effective public health interventions of the 20th century. All vaccines can be classified into different types, such as vaccines against infectious diseases, anticancer vaccines and vaccines against autoimmune diseases. In recent decades, recombinant technologies have enabled the design of experimental vaccines against a wide range of diseases using plant viruses and virus-like particles as central elements to stimulate protective and long-lasting immune responses. The analysis of recent publications shows that at least 97 experimental vaccines have been construc

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Rowe, Patricia M., Mahendra Kumar Trivedi, Gopal Nayak, Alice Branton, and Dahryn Trivedi. "Structural and Natural Isotopic Abundance Analysis of Magnesium Gluconate Treated with Energy of Consciousness (The Trivedi Effect®) Using LC-MS and NMR." Chemical and Biomolecular Engineering 2, no. 3 (2017): 124–34. https://doi.org/10.5281/zenodo.845252.

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The current research article was aimed to investigate the impact of The Trivedi Effect®- Energy of Consciousness Healing Treatment on the structural properties and isotopic abundance ratio (PM+1/PM and PM+2/PM) of magnesium gluconate using LC-MS and NMR spectroscopy. Magnesium gluconate was divided into two parts – one part was control, and another part was treated with The Trivedi Effect® remotely by eighteen renowned Biofield Energy Healers and defined as the Trivedi Effect® Treated sample. The liquid chromatogram of the control sample showed two peaks at Rt of 1.81 and 2.06 min, whereas the

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Henderson, Sally Jean, Mahendra Kumar Trivedi, Gopal Nayak, Alice Branton, and Dahryn Trivedi. "Structural and Natural Isotopic Abundance Analysis of Magnesium Gluconate Treated with Energy of Consciousness (The Trivedi Effect®) Using LC-MS and NMR." Chemical and Biomolecular Engineering 2, no. 3 (2017): 124–34. https://doi.org/10.5281/zenodo.846992.

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The current research article was aimed to investigate the impact of The Trivedi Effect®- Energy of Consciousness Healing Treatment on the structural properties and isotopic abundance ratio (PM+1/PM and PM+2/PM) of magnesium gluconate using LC-MS and NMR spectroscopy. Magnesium gluconate was divided into two parts – one part was control, and another part was treated with The Trivedi Effect® remotely by eighteen renowned Biofield Energy Healers and defined as the Trivedi Effect® Treated sample. The liquid chromatogram of the control sample showed two peaks at Rt of 1.81 and 2.06 min, whereas the

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Liu, Mengya, Tizong Miao, Su-ling Li, and Ping Wang. "Nano-antigen presenting cells for the development of therapeutic vaccines (53.2)." Journal of Immunology 186, no. 1_Supplement (2011): 53.2. http://dx.doi.org/10.4049/jimmunol.186.supp.53.2.

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Abstract Antigen presenting cells (APC) initiate immune responses against pathogens by presenting antigen and costimulatory signals to T lymphocytes. APCs loaded with antigens in vitro have been used as therapeutic vaccines to induce antiviral or tumour immune responses in chronic infectious diseases or cancer. However, the live APCs are unstable in vivo and cannot overcome the immune tolerance induced by persistent viral infection or tumour microenvironment. We have developed nano-sized APCs that are at the size of ~ 500nM and can present antigen, costimulatory molecules and bioengineered IL-

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Tang, Jianming, Mingzhu Li, Chao Zhao, et al. "Therapeutic DNA Vaccines against HPV-Related Malignancies: Promising Leads from Clinical Trials." Viruses 14, no. 2 (2022): 239. http://dx.doi.org/10.3390/v14020239.

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In 2014 and 2021, two nucleic-acid vaccine candidates named MAV E2 and VGX-3100 completed phase III clinical trials in Mexico and U.S., respectively, for patients with human papillomavirus (HPV)-related, high-grade squamous intraepithelial lesions (HSIL). These well-tolerated but still unlicensed vaccines encode distinct HPV antigens (E2 versus E6+E7) to elicit cell-mediated immune responses; their clinical efficacy, as measured by HSIL regression or cure, was modest when compared with placebo or surgery (conization), but both proved highly effective in clearing HPV infection, which should hel

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Stanfield, Brent A., Konstantin G. Kousoulas, Agustin Fernandez, and Edward Gershburg. "Rational Design of Live-Attenuated Vaccines against Herpes Simplex Viruses." Viruses 13, no. 8 (2021): 1637. http://dx.doi.org/10.3390/v13081637.

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Diseases caused by human herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) affect millions of people worldwide and range from fatal encephalitis in neonates and herpes keratitis to orofacial and genital herpes, among other manifestations. The viruses can be shed efficiently by asymptomatic carriers, causing increased rates of infection. Viral transmission occurs through direct contact of mucosal surfaces followed by initial replication of the incoming virus in skin tissues. Subsequently, the viruses infect sensory neurons in the trigeminal and lumbosacral dorsal root ganglia, where they are

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Santema, Wiebren, Victor Rutten, Ruud Segers, et al. "Postexposure Subunit Vaccination against Chronic Enteric Mycobacterial Infection in a Natural Host." Infection and Immunity 81, no. 6 (2013): 1990–95. http://dx.doi.org/10.1128/iai.01121-12.

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ABSTRACTThe control of chronic bacterial diseases with high prevalence in areas of endemicity would strongly benefit from availability of postexposure vaccines. The development of these vaccines against mycobacterial infections, such as (para)tuberculosis, is hampered by lack of experience in natural hosts. Paratuberculosis in cattle is both a mycobacterial disease of worldwide importance and a natural host model for mycobacterial infections in general. The present study showed beneficial effects of therapeutic heat shock protein 70 (Hsp70) vaccination in cattle with naturally acquired chronic

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Khatri, Vishal, Nikhil Chauhan, and Ramaswamy Kalyanasundaram. "Parasite Cystatin: Immunomodulatory Molecule with Therapeutic Activity against Immune Mediated Disorders." Pathogens 9, no. 6 (2020): 431. http://dx.doi.org/10.3390/pathogens9060431.

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The use of parasites or their products for treating chronic inflammation associated diseases (CIADs) has generated significant attention recently. Findings from basic and clinical research have provided valuable information on strengthening the notion that parasites’ molecules can be developed as biotherapeutic agents. Completion of the genome, secreotome, and proteome of the parasites has provided an excellent platform for screening and identifying several host immunomodulatory molecules from the parasites and evaluate their therapeutic potential for CIADs. One of the widely studied host immu

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