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Journal articles on the topic 'Therapeutic Responses against Inflammatory Diseases'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

La Manna, Sara, Concetta Di Natale, Daniele Florio, and Daniela Marasco. "Peptides as Therapeutic Agents for Inflammatory-Related Diseases." International Journal of Molecular Sciences 19, no. 9 (2018): 2714. http://dx.doi.org/10.3390/ijms19092714.

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Inflammation is a physiological mechanism used by organisms to defend themselves against infection, restoring homeostasis in damaged tissues. It represents the starting point of several chronic diseases such as asthma, skin disorders, cancer, cardiovascular syndrome, arthritis, and neurological diseases. An increasing number of studies highlight the over-expression of inflammatory molecules such as oxidants, cytokines, chemokines, matrix metalloproteinases, and transcription factors into damaged tissues. The treatment of inflammatory disorders is usually linked to the use of unspecific small m

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D'Elia, Riccardo V., Kate Harrison, Petra C. Oyston, Roman A. Lukaszewski, and Graeme C. Clark. "Targeting the “Cytokine Storm” for Therapeutic Benefit." Clinical and Vaccine Immunology 20, no. 3 (2013): 319–27. http://dx.doi.org/10.1128/cvi.00636-12.

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ABSTRACTInflammation is the body's first line of defense against infection or injury, responding to challenges by activating innate and adaptive responses. Microbes have evolved a diverse range of strategies to avoid triggering inflammatory responses. However, some pathogens, such as the influenza virus and the Gram-negative bacteriumFrancisella tularensis, do trigger life-threatening “cytokine storms” in the host which can result in significant pathology and ultimately death. For these diseases, it has been proposed that downregulating inflammatory immune responses may improve outcome. We rev

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Cho, Minkyoung, and Hak Sun Yu. "Therapeutic potentials of Trichinella spiralis in immune disorders: From allergy to autoimmunity." Parasites, Hosts and Diseases 63, no. 2 (2025): 123–34. https://doi.org/10.3347/phd.24086.

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The incidence of immune system diseases is increasing globally, particularly in developed countries. The hygiene and old friend hypotheses suggest that the decreased incidence of helminth infections in these countries may underlie the rising prevalence of autoimmune, allergic, and inflammatory diseases. The preventive and therapeutic potential of Trichinella spiralis, a helminthic parasite, has been well demonstrated in animal models of immune dysregulation-mediated diseases. This review comprehensively analyze how T. spiralis modulates immune responses across a spectrum of immune dysregulatio

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Das, Palamou, and Oishee Chakrabarti. "Mitochondrial DNA in innate immune responses against infectious diseases." Biochemical Society Transactions 48, no. 6 (2020): 2823–38. http://dx.doi.org/10.1042/bst20200687.

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Mitochondrial DNA (mtDNA) can initiate an innate immune response when mislocalized in a compartment other than the mitochondrial matrix. mtDNA plays significant roles in regulating mitochondrial dynamics as well as mitochondrial unfolded protein response (UPR). The mislocalized extra-mtDNA can elicit innate immune response via cGAS–STING (cyclic GMP-AMP synthase–stimulator of interferon genes) pathway, inducing the expression of the interferon-stimulated genes (ISGs). Also, cytosolic damaged mtDNA is cleared up by various pathways which are responsible for participating in the activation of in

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Jung, Hi Eun, and Heung Kyu Lee. "Current Understanding of the Innate Control of Toll-like Receptors in Response to SARS-CoV-2 Infection." Viruses 13, no. 11 (2021): 2132. http://dx.doi.org/10.3390/v13112132.

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The global coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection, threatens the entire world. It has affected every aspect of life and increased the burden on both healthcare and socioeconomic systems. Current studies have revealed that excessive inflammatory immune responses are responsible for the severity of COVID-19, which suggests that anti-inflammatory drugs may be promising therapeutic treatments. However, there are currently a limited number of approved therapeutics for COVID-19. Toll-like receptors (TLRs), which

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Rashwan, Hager K., Shahenda Mahgoub, Nermeen Z. Abuelezz, and Hatem K. Amin. "Black Cumin Seed (Nigella sativa) in Inflammatory Disorders: Therapeutic Potential and Promising Molecular Mechanisms." Drugs and Drug Candidates 2, no. 2 (2023): 516–37. http://dx.doi.org/10.3390/ddc2020027.

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Inflammation is an essential defense mechanism against harmful stimuli. However, uncontrolled inflammatory mechanisms culminate in disturbed responses that contribute to multiple serious diseases. Besides common synthetic drugs, there is a growing interest in optimizing the use of natural products as therapeutic or protective supplements against inflammatory disorders. Black cumin seed (BCS), or Nigella sativa (Family Ranunculaceae), is widely used as a health-supportive herb in the Middle East, Far East and West Asia. BCS is a rich source of phytochemicals, and studies have reported its promi

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Zheng, Miao-Yan, and Lian-Zhong Luo. "The Role of IL-17A in Mediating Inflammatory Responses and Progression of Neurodegenerative Diseases." International Journal of Molecular Sciences 26, no. 6 (2025): 2505. https://doi.org/10.3390/ijms26062505.

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IL-17A has been implicated as a critical pro-inflammatory cytokine in the pathogenesis of autoimmune and neurodegenerative disorders. Emerging evidence indicates its capacity to activate microglial cells and astrocytes, subsequently inducing the production of inflammatory mediators that exacerbate neuronal injury and functional impairment. Clinical observations have revealed a demonstrated association between IL-17A concentrations and blood–brain barrier (BBB) dysfunction, creating a pathological feedback loop that amplifies neuro-inflammatory responses. Recent advances highlight the cytokine’

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Rafe, Tanzir, Parvez Ahmed Shawon, Liyad Salem, et al. "Preventive Role of Resveratrol Against Inflammatory Cytokines and Related Diseases." Current Pharmaceutical Design 25, no. 12 (2019): 1345–71. http://dx.doi.org/10.2174/1381612825666190410153307.

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Background:Immunity is the ultimate barrier between foreign stimuli and a host cell. Unwanted immune responses can threaten the host cells and may eventually damage a vital organ. Overproduction of inflammatory cytokines may also lead to autoimmune diseases. Inflammatory cells and pro-inflammatory cytokines can eventually progress to renal, cardiac, brain, hepatic, pancreatic and ocular inflammation that can result in severe damage in the long run. Evidence also suggests that inflammation may lead to atherosclerosis, Alzheimer’s, hypertension, stroke, cysts and cancers.Methods:This study was d

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Yi, Young-Su. "Functional Role of Milk Fat Globule-Epidermal Growth Factor VIII in Macrophage-Mediated Inflammatory Responses and Inflammatory/Autoimmune Diseases." Mediators of Inflammation 2016 (2016): 1–12. http://dx.doi.org/10.1155/2016/5628486.

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Inflammation involves a series of complex biological processes mediated by innate immunity for host defense against pathogen infection. Chronic inflammation is considered to be one of the major causes of serious diseases, including a number of autoimmune/inflammatory diseases, cancers, cardiovascular diseases, and neurological diseases. Milk fat globule-epidermal growth factor 8 (MFG-E8) is a secreted protein found in vertebrates and was initially discovered as a critical component of the milk fat globule. Previously, a number of studies have reported that MFG-E8 contributes to various biologi

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Das, Kaushik, Subhojit Paul, Tanmoy Mukherjee, et al. "Beyond Macromolecules: Extracellular Vesicles as Regulators of Inflammatory Diseases." Cells 12, no. 15 (2023): 1963. http://dx.doi.org/10.3390/cells12151963.

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Inflammation is the defense mechanism of the immune system against harmful stimuli such as pathogens, toxic compounds, damaged cells, radiation, etc., and is characterized by tissue redness, swelling, heat generation, pain, and loss of tissue functions. Inflammation is essential in the recruitment of immune cells at the site of infection, which not only aids in the elimination of the cause, but also initiates the healing process. However, prolonged inflammation often brings about several chronic inflammatory disorders; hence, a balance between the pro- and anti-inflammatory responses is essent

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Yi, Young-Su. "Regulatory Roles of Flavonoids in Caspase-11 Non-Canonical Inflammasome-Mediated Inflammatory Responses and Diseases." International Journal of Molecular Sciences 24, no. 12 (2023): 10402. http://dx.doi.org/10.3390/ijms241210402.

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Inflammasomes are multiprotein complexes that activate inflammatory responses by inducing pyroptosis and secretion of pro-inflammatory cytokines. Along with many previous studies on inflammatory responses and diseases induced by canonical inflammasomes, an increasing number of studies have demonstrated that non-canonical inflammasomes, such as mouse caspase-11 and human caspase-4 inflammasomes, are emerging key players in inflammatory responses and various diseases. Flavonoids are natural bioactive compounds found in plants, fruits, vegetables, and teas and have pharmacological properties in a

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Schnitzer, Debra Jane, Mahendra Kumar Trivedi, Gopal Nayak, Alice Branton, and Dahryn Trivedi. "Investigation of Physicochemical, Spectral, and Thermal Properties of Sodium Selenate Treated with the Energy of Consciousness (The Trivedi Effect®)." American Journal of Life Sciences 5, no. 1 (2017): 27–37. https://doi.org/10.5281/zenodo.835625.

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Sodium selenate is used for the prevention and treatment of various disorders like cancer, diabetes, inflammation diseases, etc. The objective of the current study was to evaluate the effect of The Trivedi Effect®-Energy of Consciousness Healing Treatment (Biofield Energy Treatment) on physicochemical, spectral, and thermal properties of The Trivedi Effect®-Biofield Energy Treated sodium selenate using various analytical methods such as PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Sodium selenate was divided into two parts – one part was control without any treatment and anoth

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Hwang, Youn-Hwan, Hyun-Kyung Song, Ami Lee, Hyunil Ha, and Taesoo Kim. "Laminaria japonica Suppresses the Atopic Dermatitis-Like Responses in NC/Nga Mice and Inflamed HaCaT Keratinocytes via the Downregulation of STAT1." Nutrients 12, no. 11 (2020): 3238. http://dx.doi.org/10.3390/nu12113238.

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Atopic dermatitis (AD) is a skin allergy accompanied by acute and chronic dermal inflammation. In traditional oriental medicine, Laminaria japonica has been used to treat various diseases, including inflammatory diseases. Therefore, to determine the therapeutic potential of L. japonica against AD, we investigated the inhibitory effects of L. japonica water extract (LJWE) on the inflammatory mediators and AD-like skin lesions. We determined the cell viability of LJWE-treated HaCaT cells using the cell counting kit-8 assay and the levels of inflammatory cytokines using cytometric bead array kits

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Fu, Hua-Wen, and Yu-Chang Lai. "The Role of Helicobacter pylori Neutrophil-Activating Protein in the Pathogenesis of H. pylori and Beyond: From a Virulence Factor to Therapeutic Targets and Therapeutic Agents." International Journal of Molecular Sciences 24, no. 1 (2022): 91. http://dx.doi.org/10.3390/ijms24010091.

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Helicobacter pylori neutrophil-activating protein (HP-NAP), a major virulence factor of H. pylori, plays a role in bacterial protection and host inflammation. HP-NAP activates a variety of innate immune cells, including neutrophils, monocytes, and mast cells, to induce their pro-oxidant and pro-inflammatory activities. This protein also induces T-helper type 1 (Th1) immune response and cytotoxic T lymphocyte (CTL) activity, supporting that HP-NAP is able to promote gastric inflammation by activation of adaptive immune responses. Thus, HP-NAP is a potential therapeutic target for the treatment

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Choi, Yumin, Young-Lai Cho, Sujeong Park та ін. "Anti-Inflammatory Effects of Idebenone Attenuate LPS-Induced Systemic Inflammatory Diseases by Suppressing NF-κB Activation". Antioxidants 13, № 2 (2024): 151. http://dx.doi.org/10.3390/antiox13020151.

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Inflammation is a natural protective process through which the immune system responds to injury, infection, or irritation. However, hyperinflammation or long-term inflammatory responses can cause various inflammatory diseases. Although idebenone was initially developed for the treatment of cognitive impairment and dementia, it is currently used to treat various diseases. However, its anti-inflammatory effects and regulatory functions in inflammatory diseases are yet to be elucidated. Therefore, this study aimed to investigate the anti-inflammatory effects of idebenone in cecal ligation punctur

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Mieres-Castro, Daniel, Sunny Ahmar, Rubab Shabbir, and Freddy Mora-Poblete. "Antiviral Activities of Eucalyptus Essential Oils: Their Effectiveness as Therapeutic Targets against Human Viruses." Pharmaceuticals 14, no. 12 (2021): 1210. http://dx.doi.org/10.3390/ph14121210.

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Given the limited therapeutic management of infectious diseases caused by viruses, such as influenza and SARS-CoV-2, the medicinal use of essential oils obtained from Eucalyptus trees has emerged as an antiviral alternative, either as a complement to the treatment of symptoms caused by infection or to exert effects on possible pharmacological targets of viruses. This review gathers and discusses the main findings on the emerging role and effectiveness of Eucalyptus essential oil as an antiviral agent. Studies have shown that Eucalyptus essential oil and its major monoterpenes have enormous pot

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Papathanasiou, E., P. Conti, F. Carinci, D. Lauritano, and T. C. Theoharides. "IL-1 Superfamily Members and Periodontal Diseases." Journal of Dental Research 99, no. 13 (2020): 1425–34. http://dx.doi.org/10.1177/0022034520945209.

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Periodontitis is a complex, multifactorial chronic disease involving continuous interactions among bacteria, host immune/inflammatory responses, and modifying genetic and environmental factors. More than any other cytokine family, the interleukin (IL)–1 family includes key signaling molecules that trigger and perpetuate periodontal inflammation. Over the years, the IL-1 family expanded to include 11 members of cytokines, some with agonist activity (IL-1α, IL-1β, IL-18, IL-33, IL-36α, IL-36β, and IL-36γ), receptor antagonists (IL-1Ra, IL-36Ra), and 2 anti-inflammatory cytokines (IL-37, IL-38).

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Avola, Rosanna, Alessandro Giuseppe Furnari, Adriana Carol Eleonora Graziano, Alessandra Russo, and Venera Cardile. "Management of the Brain: Essential Oils as Promising Neuroinflammation Modulator in Neurodegenerative Diseases." Antioxidants 13, no. 2 (2024): 178. http://dx.doi.org/10.3390/antiox13020178.

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Neuroinflammation, a pivotal factor in the pathogenesis of various brain disorders, including neurodegenerative diseases, has become a focal point for therapeutic exploration. This review highlights neuroinflammatory mechanisms that hallmark neurodegenerative diseases and the potential benefits of essential oils in counteracting neuroinflammation and oxidative stress, thereby offering a novel strategy for managing and mitigating the impact of various brain disorders. Essential oils, derived from aromatic plants, have emerged as versatile compounds with a myriad of health benefits. Essential oi

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Park, Ji Seok, and Gail A. M. Cresci. "Dysfunctional intestinal microvascular endothelial cells: Insights and therapeutic implications in gastrointestinal inflammation." Immunometabolism 6, no. 2 (2024): e00043. http://dx.doi.org/10.1097/in9.0000000000000043.

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The intestinal microvascular endothelium plays a crucial role in orchestrating host responses to inflammation within the gastrointestinal tract. This review delves into the unique aspects of intestinal microvascular endothelial cells, distinct from those of larger vessels, in mediating leukocyte recruitment, maintaining barrier integrity, and regulating angiogenesis during inflammation. Specifically, their role in the pathogenesis of inflammatory bowel diseases, where dysregulated endothelial functions contribute to the disease progression, is reviewed. Furthermore, this review discusses the i

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Vallières, Cindy, Marie-Pierre Golinelli-Cohen, Olivier Guittet, Michel Lepoivre, Meng-Er Huang, and Laurence Vernis. "Redox-Based Strategies against Infections by Eukaryotic Pathogens." Genes 14, no. 4 (2023): 778. http://dx.doi.org/10.3390/genes14040778.

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Redox homeostasis is an equilibrium between reducing and oxidizing reactions within cells. It is an essential, dynamic process, which allows proper cellular reactions and regulates biological responses. Unbalanced redox homeostasis is the hallmark of many diseases, including cancer or inflammatory responses, and can eventually lead to cell death. Specifically, disrupting redox balance, essentially by increasing pro-oxidative molecules and favouring hyperoxidation, is a smart strategy to eliminate cells and has been used for cancer treatment, for example. Selectivity between cancer and normal c

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Salters, Stephen P., Mahendra Kumar Trivedi, Gopal Nayak, Alice Branton, and Dahryn Trivedi. "Investigation of Physicochemical, Spectral, and Thermal Properties of Sodium Selenate Treated with the Energy of Consciousness (The Trivedi Effect®)." American Journal of Life Sciences 5, no. 1 (2017): 27–37. https://doi.org/10.5281/zenodo.853132.

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Sodium selenate is used for the prevention and treatment of various disorders like cancer, diabetes, inflammation diseases, etc. The objective of the current study was to evaluate the effect of The Trivedi Effect®-Energy of Consciousness Healing Treatment (Biofield Energy Treatment) on physicochemical, spectral, and thermal properties of The Trivedi Effect®-Biofield Energy Treated sodium selenate using various analytical methods such as PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Sodium selenate was divided into two parts – one part was control without any treatment and anoth

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Hu, Wanbin, and Herman P. Spaink. "The Role of TLR2 in Infectious Diseases Caused by Mycobacteria: From Cell Biology to Therapeutic Target." Biology 11, no. 2 (2022): 246. http://dx.doi.org/10.3390/biology11020246.

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Innate immunity is considered the first line of defense against microbial invasion, and its dysregulation can increase the susceptibility of hosts to infections by invading pathogens. Host cells rely on pattern recognition receptors (PRRs) to recognize invading pathogens and initiate protective innate immune responses. Toll-like receptor 2 (TLR2) is believed to be among the most important Toll-like receptors for defense against mycobacterial infection. TLR2 has been reported to have very broad functions in infectious diseases and also in other diseases, such as chronic and acute inflammatory d

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Fiyouzi, Tara, Hector F. Pelaez-Prestel, Raquel Reyes-Manzanas, Esther M. Lafuente, and Pedro A. Reche. "Enhancing Regulatory T Cells to Treat Inflammatory and Autoimmune Diseases." International Journal of Molecular Sciences 24, no. 9 (2023): 7797. http://dx.doi.org/10.3390/ijms24097797.

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Regulatory T cells (Tregs) control immune responses and are essential to maintain immune homeostasis and self-tolerance. Hence, it is no coincidence that autoimmune and chronic inflammatory disorders are associated with defects in Tregs. These diseases have currently no cure and are treated with palliative drugs such as immunosuppressant and immunomodulatory agents. Thereby, there is a great interest in developing medical interventions against these diseases based on enhancing Treg cell function and numbers. Here, we give an overview of Treg cell ontogeny and function, paying particular attent

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Hadjadj, Jerome, Delphine Planas, Amani Ouedrani, et al. "Immunogenicity of BNT162b2 vaccine against the Alpha and Delta variants in immunocompromised patients with systemic inflammatory diseases." Annals of the Rheumatic Diseases 81, no. 5 (2022): 720–28. http://dx.doi.org/10.1136/annrheumdis-2021-221508.

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ObjectivesThe emergence of strains of SARS-CoV-2 exhibiting increase viral fitness and immune escape potential, such as the Delta variant (B.1.617.2), raises concerns in immunocompromised patients. We aimed to evaluate seroconversion, cross-neutralisation and T-cell responses induced by BNT162b2 in immunocompromised patients with systemic inflammatory diseases.MethodsProspective monocentric study including patients with systemic inflammatory diseases and healthcare immunocompetent workers as controls. Primary endpoints were anti-spike antibodies levels and cross-neutralisation of Alpha and Del

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Pawar, Alka. "Exploring the Therapeutic Promise of Melittin: Anti-Inflammatory and Anti-Cancer Applications of Bee Venom." Journal of Internal Medicine and Pharmacology (JIMP) 1, no. 04 (2024): 01–09. https://doi.org/10.61920/jimp.v1i04.34.

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Bee venom, a complex mixture of bioactive components, has garnered attention for its therapeutic properties, with melittin identified as its primary active component. This review highlights the potential of melittin in treating inflammation and cancer, two major health challenges. Inflammatory diseases, characterized by dysregulated immune responses, benefit from melittin's anti-inflammatory effects, including the inhibition of pro-inflammatory cytokines and activation of anti-inflammatory signaling pathways. Both preclinical and clinical studies have demonstrated melittin's ability to reduce

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Sivamaruthi, Bhagavathi Sundaram, Subramanian Thangaleela, Periyanaina Kesika, Natarajan Suganthy, and Chaiyavat Chaiyasut. "Mesoporous Silica-Based Nanoplatforms Are Theranostic Agents for the Treatment of Inflammatory Disorders." Pharmaceutics 15, no. 2 (2023): 439. http://dx.doi.org/10.3390/pharmaceutics15020439.

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Complete recovery from infection, sepsis, injury, or trauma requires a vigorous response called inflammation. Inflammatory responses are essential in balancing tissue homeostasis to protect the tissue or resolve harmful stimuli and initiate the healing process. Identifying pathologically important inflammatory stimuli is important for a better understanding of the immune pathways, mechanisms of inflammatory diseases and organ dysfunctions, and inflammatory biomarkers and for developing therapeutic targets for inflammatory diseases. Nanoparticles are an efficient medical tool for diagnosing, pr

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Youngblood, Bradford A., John Leung, Rustom Falahati, et al. "Discovery, Function, and Therapeutic Targeting of Siglec-8." Cells 10, no. 1 (2020): 19. http://dx.doi.org/10.3390/cells10010019.

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Siglecs (sialic acid-binding immunoglobulin-like lectins) are single-pass cell surface receptors that have inhibitory activities on immune cells. Among these, Siglec-8 is a CD33-related family member selectively expressed on human mast cells and eosinophils, and at low levels on basophils. These cells can participate in inflammatory responses by releasing mediators that attract or activate other cells, contributing to the pathogenesis of allergic and non-allergic diseases. Since its discovery in 2000, initial in vitro studies have found that the engagement of Siglec-8 with a monoclonal antibod

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Lee, Aileen Carol, Mahendra Kumar Trivedi, Gopal Nayak, Alice Branton, and Dahryn Trivedi. "Investigation of Physicochemical, Spectral, and Thermal Properties of Sodium Selenate Treated with the Energy of Consciousness (The Trivedi Effect®)." American Journal of Life Sciences 5, no. 1 (2017): 27–37. https://doi.org/10.5281/zenodo.823193.

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Sodium selenate is used for the prevention and treatment of various disorders like cancer, diabetes, inflammation diseases, etc. The objective of the current study was to evaluate the effect of The Trivedi Effect®-Energy of Consciousness Healing Treatment (Biofield Energy Treatment) on physicochemical, spectral, and thermal properties of The Trivedi Effect®-Biofield Energy Treated sodium selenate using various analytical methods such as PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Sodium selenate was divided into two parts – one part was control without any treatment and anoth

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Bigot, Jeanne, Manon Ruffin, Juliette Guitard, et al. "Effect of Flagellin Pre-Exposure on the Inflammatory and Antifungal Response of Bronchial Epithelial Cells to Fungal Pathogens." Journal of Fungi 8, no. 12 (2022): 1268. http://dx.doi.org/10.3390/jof8121268.

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Bronchial epithelial cells (BEC) play a crucial role in innate immunity against inhaled fungi. Indeed, in response to microorganisms, BEC synthesize proinflammatory cytokines involved in the recruitment of neutrophils. We have recently shown that BEC exert antifungal activity against Aspergillus fumigatus by inhibiting filament growth. In the present study, we first analyzed the inflammatory and antifungal responses of BEC infected by several fungal species such as Aspergillus spp., Scedosporium apiospermum and Candida albicans, which are frequently isolated from the sputum of people with chro

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Lee, In-Chul, and Jong-Sup Bae. "Suppressive Effects of Sulforaphane on TGFBIp-mediated Sepsis." Natural Product Communications 12, no. 10 (2017): 1934578X1701201. http://dx.doi.org/10.1177/1934578x1701201026.

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Sulforaphane (SFN) is produced when the enzyme myrosinase transforms glucoraphanin upon damage to the plant such as from chewing and effective in preventing carcinogenesis, diabetes, and inflammatory responses. Transforming growth factor β-induced protein (TGFBIp) is an extracellular matrix protein whose expression in several cell types is greatly increased by TGF-β. TGFBIp is released by human umbilical vein endothelial cells (HUVECs) and functions as a mediator of experimental sepsis. We hypothesized that SFN could reduce TGFBIp-mediated severe inflammatory responses in human endothelial cel

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Nerkar, Amit G., and Rushikesh P. Nagarkar. "Ethnopharmacological review of anticancer activity of vinca and turmeric." Current Trends in Pharmacy and Pharmaceutical Chemistry 5, no. 3 (2023): 88–93. http://dx.doi.org/10.18231/j.ctppc.2023.020.

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Natural products with immunomodulatory effects are widely used in the treatment of many diseases, including autoimmune diseases, as well as cancer and inflammatory diseases. They have attracted great interest as therapeutic agents in recent decades because they offer inexpensive and less toxic products than synthetic chemotherapy agents. Immunomodulators are substances that have the ability to improve or suppress the host's defense response, which can be used for prevention and in combination with other treatments. The anticancer effects of these immunomodulators result from their anti-inflamm

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Senapati, Sujata, Ross J. Darling, Kathleen A. Ross, Michael J. Wannemeuhler, Balaji Narasimhan, and Surya K. Mallapragada. "Self-assembling synthetic nanoadjuvant scaffolds cross-link B cell receptors and represent new platform technology for therapeutic antibody production." Science Advances 7, no. 32 (2021): eabj1691. http://dx.doi.org/10.1126/sciadv.abj1691.

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Host antibody responses are pivotal for providing protection against infectious agents. We have pioneered a new class of self-assembling micelles based on pentablock copolymers that enhance antibody responses while providing a low inflammatory environment compared to traditional adjuvants. This type of “just-right” immune response is critical in the rational design of vaccines for older adults. Here, we report on the mechanism of enhancement of antibody responses by pentablock copolymer micelles, which act as scaffolds for antigen presentation to B cells and cross-link B cell receptors, unlike

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Yang, Ge, Pin Wan, Yaru Zhang, et al. "Innate Immunity, Inflammation, and Intervention in HBV Infection." Viruses 14, no. 10 (2022): 2275. http://dx.doi.org/10.3390/v14102275.

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Hepatitis B virus (HBV) infection is still one of the most dangerous viral illnesses. HBV infects around 257 million individuals worldwide. Hepatitis B in many individuals ultimately develops hepatocellular carcinoma (HCC), which is the sixth most common cancer and the third leading cause of cancer-related deaths worldwide. The innate immunity acts as the first line of defense against HBV infection through activating antiviral genes. Along with the immune responses, pro-inflammatory cytokines are triggered to enhance the antiviral responses, but this may result in acute or chronic liver inflam

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Lee, Eun-Gyeong, Sung-Kun Yim, Sang-Min Kang, et al. "Phlorofucofuroeckol-A: A Natural Compound with Potential to Attenuate Inflammatory Diseases Caused by Airborne Fine Dust." Medicina 61, no. 1 (2025): 165. https://doi.org/10.3390/medicina61010165.

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Background and Objectives: Persistent exposure to airborne fine dust (FD) particles contributing to air pollution has been linked to various human health issues, including respiratory inflammation, allergies, and skin diseases. We aimed to identify potential seaweed anti-inflammatory bioactive reagents and determine their effects on systemic inflammatory responses induced by FD particles. Materials and Methods: While exploring anti-inflammatory bioactive reagents, we purified compounds with potential anti-inflammatory effects from the seaweed extracts of Ecklonia cava, Ecklonia stolonifera, an

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Patra, VijayKumar, Irène Gallais Sérézal, and Peter Wolf. "Potential of Skin Microbiome, Pro- and/or Pre-Biotics to Affect Local Cutaneous Responses to UV Exposure." Nutrients 12, no. 6 (2020): 1795. http://dx.doi.org/10.3390/nu12061795.

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The human skin hosts innumerable microorganisms and maintains homeostasis with the local immune system despite the challenges offered by environmental factors such as ultraviolet radiation (UVR). UVR causes cutaneous alterations such as acute (i.e., sunburn) and chronic inflammation, tanning, photoaging, skin cancer, and immune modulation. Phototherapy on the other hand is widely used to treat inflammatory skin diseases such as psoriasis, atopic dermatitis, polymorphic light eruption and graft-versus-host disease (GvHD), as well as neoplastic skin diseases such as cutaneous T cell lymphoma, am

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Hornung, Matthew Charles, Mahendra Kumar Trivedi, Gopal Nayak, Alice Branton, and Dahryn Trivedi. "Investigation of Physicochemical, Spectral, and Thermal Properties of Sodium Selenate Treated with the Energy of Consciousness (The Trivedi Effect®)." American Journal of Life Sciences 5, no. 1 (2017): 27–37. https://doi.org/10.5281/zenodo.844584.

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Sodium selenate is used for the prevention and treatment of various disorders like cancer, diabetes, inflammation diseases, etc. The objective of the current study was to evaluate the effect of The Trivedi Effect®-Energy of Consciousness Healing Treatment (Biofield Energy Treatment) on physicochemical, spectral, and thermal properties of The Trivedi Effect®-Biofield Energy Treated sodium selenate using various analytical methods such as PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Sodium selenate was divided into two parts – one part was control without any treatment and anoth

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Wang, Yaru, Bailing Wei, Mingyang Leng, et al. "Fraxin Alleviates Atherosclerosis by Inhibiting Oxidative Stress and Inflammatory Responses via the TLR4/PI3K/Akt Pathway." Current Issues in Molecular Biology 47, no. 5 (2025): 308. https://doi.org/10.3390/cimb47050308.

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Fraxin is a bioactive compound derived from Cortex Fraxini. It is known for its diverse biological activities and numerous benefits, including anti-inflammatory, antioxidant, analgesic, antimicrobial, antiviral, and immunomodulatory effects. Despite growing interest in natural compounds for cardiovascular diseases Fraxin’s atheroprotective properties and molecular targets have not yet been fully elucidated. To address this gap, our research employed an integrated approach combining network pharmacology, molecular docking simulations, and in vitro biological validation to systematically unravel

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Jang, Young Jin, Jae Hwan Kim, and Sanguine Byun. "Modulation of Autophagy for Controlling Immunity." Cells 8, no. 2 (2019): 138. http://dx.doi.org/10.3390/cells8020138.

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Autophagy is an essential process that maintains physiological homeostasis by promoting the transfer of cytoplasmic constituents to autophagolysosomes for degradation. In immune cells, the autophagy pathway plays an additional role in facilitating proper immunological functions. Specifically, the autophagy pathway can participate in controlling key steps in innate and adaptive immunity. Accordingly, alterations in autophagy have been linked to inflammatory diseases and defective immune responses against pathogens. In this review, we discuss the various roles of autophagy signaling in coordinat

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Lambiase, Alessandro, Alessandra Micera, Marta Sacchetti, Flavio Mantelli, and Stefano Bonini. "Toll-like receptors in ocular surface diseases: overview and new findings." Clinical Science 120, no. 10 (2011): 441–50. http://dx.doi.org/10.1042/cs20100425.

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The ocular surface is the first line of defence in the eye against environmental microbes. The ocular innate immune system consists of a combination of anatomical, mechanical and immunological defence mechanisms. TLRs (Toll-like receptors), widely expressed by the ocular surface, are able to recognize microbial pathogens and to trigger the earliest immune response leading to inflammation. Increasing evidence highlights the crucial role of TLRs in regulating innate immune responses during ocular surface infective and non-infective inflammatory conditions. In addition, recent observations have s

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Alanazi, Hamad H., Abdelbaset Mohamed Elasbali, Maged K. Alanazi, and Eman Fawzy El Azab. "Medicinal Herbs: Promising Immunomodulators for the Treatment of Infectious Diseases." Molecules 28, no. 24 (2023): 8045. http://dx.doi.org/10.3390/molecules28248045.

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Humans are constantly at high risk of emerging pandemics caused by viral and bacterial infections. The emergence of new pandemics is mainly caused by evolved viruses and bacteria that are highly resistant to existing medications. The rapid evolution of infectious agents demands the urgent investigation of new therapeutic strategies to prevent and treat these infections at an early stage. One of these therapeutic strategies includes the use of medicinal herbs for their antibacterial and antiviral properties. The use of herbal medicines as remedies is very ancient and has been employed for centu

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Khan, Imran Ahmad, Musaddique Hussain, Nadia Hussain, Ali M. Alqahtani, and Taha Alqahtani. "Cardioprotective Effect of Rumex vesicarius Linn. Leaf Extract against Catecholamine-Induced Cardiotoxicity." Molecules 27, no. 11 (2022): 3383. http://dx.doi.org/10.3390/molecules27113383.

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Rumex vesicarius (L.) is a folklore medicinal herb that has been used for centuries to cure cardiovascular diseases. The present work was carefully designed to ascertain the pharmacological basis for R. vesicarius’s therapeutic efficacy in cardiovascular diseases, as well as the underlying mechanism. In the ex vivo investigation, the aqueous-methanolic leaf extract of R. vesicarius was shown to have endothelium-dependent vasorelaxant effects in rabbit aorta tissue preparations, and its hypotensive responses were quantified by pressure and force transducers coupled to the Power Lab Data Acquisi

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Lyly, Annina, Anu Laulajainen-Hongisto, Philippe Gevaert, Paula Kauppi, and Sanna Toppila-Salmi. "Monoclonal Antibodies and Airway Diseases." International Journal of Molecular Sciences 21, no. 24 (2020): 9477. http://dx.doi.org/10.3390/ijms21249477.

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Monoclonal antibodies, biologics, are a relatively new treatment option for severe chronic airway diseases, asthma, allergic rhinitis, and chronic rhinosinusitis (CRS). In this review, we focus on the physiological and pathomechanisms of monoclonal antibodies, and we present recent study results regarding their use as a therapeutic option against severe airway diseases. Airway mucosa acts as a relative barrier, modulating antigenic stimulation and responding to environmental pathogen exposure with a specific, self-limited response. In severe asthma and/or CRS, genome–environmental interactions

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Khatri, Vishal, Nikhil Chauhan, and Ramaswamy Kalyanasundaram. "Parasite Cystatin: Immunomodulatory Molecule with Therapeutic Activity against Immune Mediated Disorders." Pathogens 9, no. 6 (2020): 431. http://dx.doi.org/10.3390/pathogens9060431.

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The use of parasites or their products for treating chronic inflammation associated diseases (CIADs) has generated significant attention recently. Findings from basic and clinical research have provided valuable information on strengthening the notion that parasites’ molecules can be developed as biotherapeutic agents. Completion of the genome, secreotome, and proteome of the parasites has provided an excellent platform for screening and identifying several host immunomodulatory molecules from the parasites and evaluate their therapeutic potential for CIADs. One of the widely studied host immu

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Griffin, John Lawrence, Mahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi, and Gopal Nayak. "Effect of the Energy of Consciousness (The Trivedi Effect®) on Physicochemical, Thermal, Structural, and Behavioral Properties of Magnesium Gluconate." Chemical and Biomolecular Engineering 2, no. 2 (2017): 113–23. https://doi.org/10.5281/zenodo.884138.

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Magnesium gluconate is an organometallic pharmaceutical compound used for the prevention and treatment of hypomagnesemia. The objective of the current research work was to examine the influence of The Trivedi Effect®-Energy of Consciousness Healing Treatment (Biofield Energy Treatment) on magnesium gluconate for the alteration in the physicochemical, structural, thermal and behavioral properties using PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Magnesium gluconate was divided into two parts – one part was control without any Biofield Energy Treatment, while another part was t

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Severo, Juliana Soares, Alda Cássia Alves da Silva, Brenda Lois Barros dos Santos, et al. "Physical Exercise as a Therapeutic Approach in Gastrointestinal Diseases." Journal of Clinical Medicine 14, no. 5 (2025): 1708. https://doi.org/10.3390/jcm14051708.

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Background/Objectives: Physical exercise can have significant consequences for the gastrointestinal tract, which is why there have been studies into its influence on the treatment of conditions such as colorectal cancer, inflammatory bowel diseases (IBD), and irritable bowel syndrome (IBS), being that there is epidemiological evidence that exercise has a protective effect against colon cancer. This review aims to demonstrate the mechanisms of action of physical exercise in the gastrointestinal tract, as well as the benefits of exercise in diseases associated with the digestive system, in addit

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Rashid, Mudasir, Rumaisa Rashid, Sabtain Saroya, Mrinalini Deverapalli, Hassan Brim, and Hassan Ashktorab. "Saffron as a Promising Therapy for Inflammatory Bowel Disease." Nutrients 16, no. 14 (2024): 2353. http://dx.doi.org/10.3390/nu16142353.

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Inflammatory bowel disease (IBD) is a chronic inflammatory illness of the gastrointestinal tract (GI), characterized by recurrent episodes of inflammation and tissue destruction. It affects an increasing number of individuals worldwide who suffer from Crohn’s disease (CD) or ulcerative colitis (UC). Despite substantial advances in understanding the underlying causes of IBD, the available treatments remain restricted and are sometimes accompanied by severe consequences. Consequently, there is an urgent need to study alternate therapeutic options. This review assesses the present drugs, identifi

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Barreto de Albuquerque, Juliana, Christoph Mueller, and Bilgi Gungor. "Tissue-Resident T Cells in Chronic Relapsing–Remitting Intestinal Disorders." Cells 10, no. 8 (2021): 1882. http://dx.doi.org/10.3390/cells10081882.

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Tissue-resident memory T (TRM) cells critically contribute to the rapid immunoprotection and efficient immunosurveillance against pathogens, particularly in barrier tissues, but also during anti-tumor responses. However, the involvement of TRM cells also in the induction and exacerbation of immunopathologies, notably in chronically relapsing auto-inflammatory disorders, is becoming increasingly recognized as a critical factor. Thus, TRM cells may also represent an attractive target in the management of chronic (auto-) inflammatory disorders, including multiple sclerosis, rheumatoid arthritis,

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Wang, YL, Y. Zhang, T. Liu, and J. Cui. "3,5-Dimethoxy-4-hydroxy myricanol attenuated oxidative stress-induced toxicity on cardiomyoblast cells." Human & Experimental Toxicology 40, no. 9 (2021): 1485–95. http://dx.doi.org/10.1177/0960327121997977.

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Myocardial ischemia is the main reason for ischemic heart diseases. Antioxidant treatment is considered as a possible approach to prevent myocardial ischemia injury, because oxidative stress is a key factor triggering it. This study was to investigate the protective effects of 3,5-dimethoxy-4-hydroxy myricanol (DHM) against oxidative stress-induced cytotoxicity on H9c2 cells and further explore its mechanisms. The oxidative stress and inflammatory response markers were detected by H2DCFDA fluorescent measurement, enzyme-linked immunosorbent assay (ELISA), real-time PCR and Western blot. Result

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Khan, Abdul Waheed, Mariya Farooq, Moon-Jung Hwang, Muhammad Haseeb, and Sangdun Choi. "Autoimmune Neuroinflammatory Diseases: Role of Interleukins." International Journal of Molecular Sciences 24, no. 9 (2023): 7960. http://dx.doi.org/10.3390/ijms24097960.

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Autoimmune neuroinflammatory diseases are a group of disorders resulting from abnormal immune responses in the nervous system, causing inflammation and tissue damage. The interleukin (IL) family of cytokines, especially IL-1, IL-6, and IL-17, plays a critical role in the pathogenesis of these diseases. IL-1 is involved in the activation of immune cells, production of pro-inflammatory cytokines, and promotion of blood-brain barrier breakdown. IL-6 is essential for the differentiation of T cells into Th17 cells and has been implicated in the initiation and progression of neuroinflammation. IL-17

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Kammerl, Ilona E., and Silke Meiners. "Proteasome function shapes innate and adaptive immune responses." American Journal of Physiology-Lung Cellular and Molecular Physiology 311, no. 2 (2016): L328—L336. http://dx.doi.org/10.1152/ajplung.00156.2016.

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The proteasome system degrades more than 80% of intracellular proteins into small peptides. Accordingly, the proteasome is involved in many essential cellular functions, such as protein quality control, transcription, immune responses, cell signaling, and apoptosis. Moreover, degradation products are loaded onto major histocompatibility class I molecules to communicate the intracellular protein composition to the immune system. The standard 20S proteasome core complex contains three distinct catalytic active sites that are exchanged upon stimulation with inflammatory cytokines to form the so-c

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