Relevant bibliographies by topics / Therapeutic target identification

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Therapeutic target identification'

Author: Grafiati
Published: 16 November 2024
Last updated: 25 July 2025

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Journal articles on the topic "Therapeutic target identification"

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Koscielny, Gautier, Peter An, Denise Carvalho-Silva, et al. "Open Targets: a platform for therapeutic target identification and validation." Nucleic Acids Research 45, no. D1 (2016): D985—D994. http://dx.doi.org/10.1093/nar/gkw1055.

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Bajorath, Jürgen. "Identification and validation of therapeutic target proteins." TARGETS 1, no. 2 (2002): 45–46. http://dx.doi.org/10.1016/s1477-3627(02)02194-3.

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Hassan, Md Imtaiyaz. "Multi-omics approaches to therapeutic target identification." Briefings in Functional Genomics 22, no. 2 (2023): 75. http://dx.doi.org/10.1093/bfgp/elac058.

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Liao, Jianbo, Qinyu Wang, Fengxu Wu, and Zunnan Huang. "In Silico Methods for Identification of Potential Active Sites of Therapeutic Targets." Molecules 27, no. 20 (2022): 7103. http://dx.doi.org/10.3390/molecules27207103.

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Target identification is an important step in drug discovery, and computer-aided drug target identification methods are attracting more attention compared with traditional drug target identification methods, which are time-consuming and costly. Computer-aided drug target identification methods can greatly reduce the searching scope of experimental targets and associated costs by identifying the diseases-related targets and their binding sites and evaluating the druggability of the predicted active sites for clinical trials. In this review, we introduce the principles of computer-based active s
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Keerthana N and Koteeswaran K. "Target identification and validation in research." World Journal of Biology Pharmacy and Health Sciences 17, no. 3 (2024): 107–17. http://dx.doi.org/10.30574/wjbphs.2024.17.3.0116.

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Target identification is a critical step in biomedical research because it lays the groundwork for the development of new therapies and drugs. Genetic research, including genome-wide association studies (GWAS), genomic sequencing, functional genomics, and data integration, is crucial for understanding disease genetics and potential treatment targets. Transcriptomics and proteomics give data on gene and protein expression, making it easier to identify targets in dysregulated diseases. Target identification is essential for drug discovery, precision medicine, lowering medication attrition, incre
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Keerthana, N., and K. Koteeswaran. "Target identification and validation in research." World Journal of Biology Pharmacy and Health Sciences 17, no. 3 (2024): 107–17. https://doi.org/10.5281/zenodo.11351494.

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Target identification is a critical step in biomedical research because it lays the groundwork for the development of new therapies and drugs. Genetic research, including genome-wide association studies (GWAS), genomic sequencing, functional genomics, and data integration, is crucial for understanding disease genetics and potential treatment targets. Transcriptomics and proteomics give data on gene and protein expression, making it easier to identify targets in dysregulated diseases. Target identification is essential for drug discovery, precision medicine, lowering medication attrition, incre
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Zou, Mingjie, Haiyuan Zhou, Letian Gu, Jingzi Zhang, and Lei Fang. "Therapeutic Target Identification and Drug Discovery Driven by Chemical Proteomics." Biology 13, no. 8 (2024): 555. http://dx.doi.org/10.3390/biology13080555.

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Throughout the human lifespan, from conception to the end of life, small molecules have an intrinsic relationship with numerous physiological processes. The investigation into small-molecule targets holds significant implications for pharmacological discovery. The determination of the action sites of small molecules provide clarity into the pharmacodynamics and toxicological mechanisms of small-molecule drugs, assisting in the elucidation of drug off-target effects and resistance mechanisms. Consequently, innovative methods to study small-molecule targets have proliferated in recent years, wit
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Hu, Yang, Yinteng Wu, Fu Gan, et al. "Identification of Potential Therapeutic Target Genes in Osteoarthritis." Evidence-Based Complementary and Alternative Medicine 2022 (August 13, 2022): 1–15. http://dx.doi.org/10.1155/2022/8027987.

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Objective. Osteoarthritis (OA), also known as joint failure, is characterized by joint pain and, in severe cases, can lead to loss of joint function in patients. Immune-related genes and immune cell infiltration play a crucial role in OA development. We used bioinformatics approaches to detect potential diagnostic markers and available drugs for OA while initially exploring the immune mechanisms of OA. Methods. The training set GSE55235 and validation set GSE51588 and GSE55457 were obtained from the Gene Expression Omnibus (GEO) database and differentially expressed genes (DEGs) were identifie
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Frühwald, M. C., and C. Plass. "Metastatic medulloblastoma—therapeutic success through molecular target identification?" Pharmacogenomics Journal 2, no. 1 (2002): 7–10. http://dx.doi.org/10.1038/sj.tpj.6500077.

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Traa, Annika, Emily Machiela, Paige D. Rudich, Sonja K. Soo, Megan M. Senchuk, and Jeremy M. Van Raamsdonk. "Identification of Novel Therapeutic Targets for Polyglutamine Diseases That Target Mitochondrial Fragmentation." International Journal of Molecular Sciences 22, no. 24 (2021): 13447. http://dx.doi.org/10.3390/ijms222413447.

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Huntington’s disease (HD) is one of at least nine polyglutamine diseases caused by a trinucleotide CAG repeat expansion, all of which lead to age-onset neurodegeneration. Mitochondrial dynamics and function are disrupted in HD and other polyglutamine diseases. While multiple studies have found beneficial effects from decreasing mitochondrial fragmentation in HD models by disrupting the mitochondrial fission protein DRP1, disrupting DRP1 can also have detrimental consequences in wild-type animals and HD models. In this work, we examine the effect of decreasing mitochondrial fragmentation in a n
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Dissertations / Theses on the topic "Therapeutic target identification"

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Park, Jong Kook. "Target Identification, Therapeutic Application and Maturation Mechanism of microRNAs." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1331096696.

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Cheung, Chi-ho, and 張志豪. "Identification of CD47 as a novel therapeutic target for hepatocellular carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46945374.

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Hendley, Rhiannon. "Identification of Lyn kinase as a therapeutic target for tamoxifen resistant breast cancer." Thesis, Cardiff University, 2012. http://orca.cf.ac.uk/31462/.

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Tamoxifen has made a significant contribution in decreasing breast cancer related deaths for over 30 years and until recently was the gold standard for treatment of ER positive breast cancer (Fisher et al, 1998). Resistance to tamoxifen is however a considerable issue with cells utilising a number of molecular mechanisms to bypass the growth inhibition caused by blocking ER activity. This move towards an anti-hormone resistant state from an antihormone responsive state is associated with the transition to a much more aggressive phenotype including increased proliferation and also invasiveness.
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Paudel, Nirmala. "Computational analysis of biochemical networks for drug target identification and therapeutic intervention design." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/90152.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2014.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 96-104).<br>Identification of effective drug targets to intervene, either as single agent therapy or in combination, is a critical question in drug development. As complexity of disease like cancer is revealed, it has become clear that a holistic network approach is needed to identify drug targets that are specially positioned to provide desired leverage on disease phenotypes. In this thesis we develop a comput
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BENINI, MONICA. "Identification of the frataxin-specific E3 ligase as a potential therapeutic target for Friedreich’s Ataxia." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2015. http://hdl.handle.net/2108/203003.

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Friedreich’s ataxia (FRDA) is a rare debilitating, life-shortening, autosomal recessive inherited disease that leads to progressive damage to the nervous system. Onset is usually around the puberty and patients develop a progressive loss of motor coordination, inability to walk, slurred speech, and a cardiac hypertrophy that often leads to premature death. The particular genetic mutation – expansion of an intronic GAA triplet repeat in the FXN gene – leads to reduced expression of the mitochondrial protein frataxin involved in iron-sulfur cluster biogenesis. The subsequent frataxin insufficien
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TRICARICO, PAOLA MAURA. "Mevalonate Kinase Deficiency: identification of new therapeutic target, in vitro and in vivo pathogenic study." Doctoral thesis, Università degli Studi di Trieste, 2016. http://hdl.handle.net/11368/2908002.

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Il Difetto di Mevalonato Chinasi (MKD) è una malattia rara autoinfiammatoria autosomica recessiva, causata da mutazioni nel gene MVK che codifica per mevalonato chinasi (MK), enzima chiave della via del mevalonato. Questa via è importante per la produzione di colesterolo, ed anche geranilgeranil pirofosfato e farnesil pirofosfato essenziali per la prenilazione delle proteine. MKD ha fenotipi clinici eterogenei, infatti, si va da una forma lieve, la sindrome iper-IgD (HIDS), ad una forma più grave, la Mevalonica Aciduria (MA). HIDS è caratterizzata da sintomi eterogenei che comprendono febbri r
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Hoppe, Stephanie [Verfasser], and Martin [Akademischer Betreuer] Müller. "Identification of target T cell epitopes for a therapeutic HPV16 vaccine / Stephanie Hoppe ; Betreuer: Martin Müller." Heidelberg : Universitätsbibliothek Heidelberg, 2019. http://d-nb.info/1177043491/34.

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Slim, Lotfi. "Detection of epistasis in genome wide association studies with machine learning methods for therapeutic target identification." Thesis, Université Paris sciences et lettres, 2020. https://pastel.archives-ouvertes.fr/tel-02895919.

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En offrant une image sans précédent du génome humain, les études d'association pangénomiques (GWAS) expliqueraient pleinement le contexte génétique des maladies complexes. A ce jour, les résultats ont été pour le moins mitigés. Cela peut être partiellement attribué à la méthodologie statistique adoptée, qui ne prend pas souvent en compte l'interaction entre les variants génétiques, ou l'épistasie. La détection d'épistasie à travers des modèles statistiques présente plusieurs défis pour lesquels nous développons dans cette thèse une paire d'outils adéquats. Le premier outil, epiGWAS, utilise l'
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Maule, Francesca. "Identification of Annexin 2A as a fundamental mediator of glioblastoma cell dissemination and potential therapeutic target." Doctoral thesis, Università degli studi di Padova, 2017. http://hdl.handle.net/11577/3422285.

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Glioblastoma multiforme (GBM) is the most devastating tumor of the brain, characterized by an almost inevitable tendency to recur after intensive treatments and a fatal prognosis. Indeed, despite recent technical improvements in GBM surgery, the complete eradication of cancer cell disseminated outside the tumor mass still remains a crucial issue for glioma patients management. In my PhD project, we identified Annexin 2A (ANXA2) as an important intracellular cytoskeletal protein expressed also on the surface of various types of cancer cells. Initially, we show that ANXA2 is over-expressed in IV
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Cole, Clare Louise. "Identification of OATP1B3 as a potential therapeutic target in Recessive Dystrophic Epidermolysis Bullosa Associated Squamous Cell Carcinoma." Thesis, University of Dundee, 2011. https://discovery.dundee.ac.uk/en/studentTheses/20729995-be96-4f29-80b8-53da131c6fd8.

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Epidermolysis Bullosa encompasses a group of inherited heterogeneous diseases involving trauma induced blistering of the skin. Recessive Dystrophic Epidermolysis Bullosa (RDEB) is one of the most debilitating variants of the disease and patients are predisposed to developing aggressive cutaneous Squamous Cell Carcinoma (SCC). Unlike SCC in the general population, the primary cause of RDEB associated SCC is not UV-radiation. SCC in RDEB patients has poor prognosis due to a high frequency of recurrence and metastasis. 70% of all severe generalized RDEB patients die from SCC by the age of 45, com
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Books on the topic "Therapeutic target identification"

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Hallczuk, Howard. Therapeutic Target Identification : Validation and Drug Discovery for Traumatic Brain Injury: Mild Traumatic Brain Injury. Independently Published, 2021.

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Popescu, Bogdan Florin Gh, Yong Guo, and Claudia Francesca Lucchinetti. Multiple Sclerosis: Pathology. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0081.

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The pathology of MS consists of areas of focal demyelination, known as plaques or lesions, characterized by inflammation, gliosis, and relative axonal preservation. Recent neuropathological studies have established that white matter lesions are heterogenous with respect to the targets of injury and mechanisms of demyelination, highlighting the need for the identification of surrogate clinical and/or paraclinical markers that would correlate with immunopatterns in the general MS population and for the design of novel therapeutic strategies specifically tailored to each immunopattern. Recent neu
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Drouin-Ouellet, Janelle, and Roger A. Barker. Disease-Modifying Therapies in Neurodegenerative Disorders. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190233563.003.0016.

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The recent identification of the genetic basis of many neurodegenerative disorders (NDDs), coupled with a greater understanding of their pathophysiology, has enabled better therapeutic strategies to be identified and tried. This includes approaches that target critical specific nodes in the disease pathways, for example, agents that modulate levels of mutant huntingtin in Huntington’s disease. In addition to these highly specific targeted therapies, there is also a growing realization that more generic lifestyle therapies influencing whole brain health may also have merit in treating these con
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Lazarov, Amit, Adva Segal, and Yair Bar-Haim. Cognitive Training and Technology in the Treatment of Children and Adolescents. Edited by Thomas H. Ollendick, Susan W. White, and Bradley A. White. Oxford University Press, 2018. http://dx.doi.org/10.1093/oxfordhb/9780190634841.013.47.

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Cognitive training approaches in the treatment of pediatric psychopathology rely on the identification of specific aberrant cognitive processes that could be targeted for rectification via training. Such processes include threat-related attention and interpretation, working memory, and emotion recognition, among others. A selective review is given of mental processes that have been identified as potential targets for psychological treatment and the technologies that could be harnessed for such therapeutic targeting. Implementation of cognitive training procedures in the treatment of children,
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Modern CNS Drug Discovery : Novel Therapeutics for Psychiatric and Neurological Diseases: From Target Identification to Regulatory Approval. Springer International Publishing AG, 2024.

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Hwang, Young-Hwan, and York Pei. Autosomal dominant polycystic kidney disease management. Edited by Neil Turner. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0309_update_001.

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Management of patients with autosomal dominant polycystic kidney disease (ADPKD) currently comprises non-specific measures including promotion of healthy lifestyle, optimization of blood pressure control, and modification of cardiovascular risk factors. A high water intake of 3–4 L per day in patients with glomerular filtration rate greater than 30 mL/min/1.73 m2 may decrease the risk of kidney stones, but its potential benefit in reducing renal cyst growth is presently unproven. Maintenance of a target blood pressure of 130/80 mmHg is recommended by expert clinical guidelines though this is u
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Beyer, Chad E., and Stephen M. Stahl, eds. Next Generation Antidepressants. Cambridge University Press, 2010. http://dx.doi.org/10.1017/9780511778414.

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The World Health Organization defines depression as a primary contributor to the global burden of disease and predicts it will become the second leading cause of death by 2020. The need to develop effective therapies has never been so pressing. Current antidepressant drugs have several limitations. This 2010 book looks at the future of mood-disorder research, covering the identification of new therapeutic targets, establishing new preclinical models, new medicinal chemistry opportunities, and fostering greater understanding of genetic influences. These strategies are likely to help build a bet
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Book chapters on the topic "Therapeutic target identification"

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Zhou, Yu, and James D. Marks. "Identification of Target and Function Specific Antibodies for Effective Drug Delivery." In Therapeutic Antibodies. Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-554-1_7.

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Vinci, Maria, Carol Box, Miriam Zimmermann, and Suzanne A. Eccles. "Tumor Spheroid-Based Migration Assays for Evaluation of Therapeutic Agents." In Target Identification and Validation in Drug Discovery. Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-311-4_16.

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Spaceinvaders, Karen. "Please Mind the Gap." In continent. Year 1. punctum books, 2012. https://doi.org/10.21983/p3.0016.1.13.

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Please scan the qrcode to access the mp3 files of deep brain recordings of individual brain cells, the smallest unit of the brain, in a whole, intact liv-ing brain. Each brain region’s cells possess an electrical signature. During recordings electrical signals are transformed into sound to facilitate auditory identification of cells during a process called “mapping.” Mapping is an important step in successfully identifying and localizing the appropriate target site in the brain for an experimental therapeutic proce-dure called deep brain stimulation which has been used for patients with moveme
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Cheung, Atwood K., and Feng Cong. "Finding a Needle in a Haystack. Identification of Tankyrase, a Novel Therapeutic Target of the Wnt Pathway Using Chemical Genetics." In Concepts and Case Studies in Chemical Biology. Wiley-VCH Verlag GmbH & Co. KGaA, 2014. http://dx.doi.org/10.1002/9783527687503.ch17.

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Garg, Aakriti, Ruchika Sharma, Santanu Kaity, and Anoop Kumar. "Identification of Bioactive Lipid Drug Targets by Computational Techniques." In Therapeutic Platform of Bioactive Lipids. Apple Academic Press, 2023. http://dx.doi.org/10.1201/9781003301608-10.

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Watson, Geoffrey Alan, Kirsty Taylor, and Lillian L. Siu. "Innovation and Advances in Precision Medicine in Head and Neck Cancer." In Critical Issues in Head and Neck Oncology. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-63234-2_24.

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AbstractThe clinical utility of precision medicine through molecular characterization of tumors has been demonstrated in some malignancies, especially in cases where oncogenic driver alterations are identified. Next generation sequencing data from thousands of patients with head and neck cancers have provided vast amounts of information about the genomic landscape of this disease. Thus far, only a limited number of genomic alterations have been druggable, such as NTRK gene rearrangements in salivary gland cancers (mainly mammary analogue secretory carcinoma), NOTCH mutations in adenoid cystic
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Calabretta, Raffaella, and Marcus Hacker. "Cardiotoxicity of Targeted Therapies: Imaging of Heart Does Matter." In Beyond Becquerel and Biology to Precision Radiomolecular Oncology: Festschrift in Honor of Richard P. Baum. Springer International Publishing, 2024. http://dx.doi.org/10.1007/978-3-031-33533-4_12.

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AbstractMolecular targeted therapies are characterized by blocking essential biochemical pathways or mutant proteins that are required for cancer cell growth and survival. Targeted cancer therapeutics are amongst the major treatment options for cancer today. These treatments are more selective for cancer cells and improve the quality of life for cancer patients undergoing therapy. Nevertheless, cardiotoxicity is a frequent side effect in targeted therapies, frequently described as myocardial dysfunction and heart failure. Cardiotoxicity includes also any subsequent functional or structural hea
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Ng, Esther Feng Ying, and Franz Meitinger. "Genetic Engineering and Screening Using Base Editing and Inducible Gene Knockout." In Methods in Molecular Biology. Springer US, 2024. https://doi.org/10.1007/978-1-0716-4224-5_12.

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AbstractGenetic engineering and screening in human cells are powerful techniques for the precise and comprehensive identification and analysis of gene and protein domain functions. Genome-wide knockout screens have been extensively utilized to discover essential genes, tumor suppressors, and genes that regulate responses to various chemicals, including antimitotic and therapeutic drugs. The advent of base editors, which facilitate the targeted mutation of single amino acids, has advanced the identification of critical and functional domains or motifs. In this context, we outline methods for cr
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Singh, Ankita, Shafaque Zahra, Simran Arora, Fiza Hamid, and Shailesh Kumar. "In Silico Identification of tRNA Fragments, Novel Candidates for Cancer Biomarkers, and Therapeutic Targets." In Methods in Molecular Biology. Springer US, 2024. http://dx.doi.org/10.1007/978-1-0716-3886-6_21.

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Mathie, Alistair, Samuel R. Bourne, Rachel Forfar, Walter E. Perfect, and Emma L. Veale. "The Contribution of Genetic Sequencing Information to the Identification and Functional Characterization of Two-Pore Domain Potassium (K2P) Channels as Viable Therapeutic Targets." In Ion Channels as Targets in Drug Discovery. Springer International Publishing, 2024. http://dx.doi.org/10.1007/978-3-031-52197-3_6.

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Conference papers on the topic "Therapeutic target identification"

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Devina, Kezia Elian, Dono Indarto, and Tri Nugraha Susilawati. "Identification of Quercetin and Chrysin in Banana Peel Extract Using High Performance Liquid Chromatography and Liquid Chromatography Mass Spectrometer for Obesity Treatment." In 8th International Conference on Advanced Material for Better Future. Trans Tech Publications Ltd, 2025. https://doi.org/10.4028/p-6iz2xi.

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Pancreatic lipase plays an important role in converting triglyceride into long-chain fatty acids and glycerol, then becomes a therapeutic target for obesity treatment. Quercetin and chrysin are able to inhibit pancreatic lipase, which is potentially developed for obesity treatment. This study aimed to identify quercetin and chrysin derived from the methanol extract of raja and kepok banana peels using High Performance Liquid Chromatography (HPLC) and Liquid Chromatography Mass Spectrometer (LC-MS) for the development of obesity treatment. Raja and kepok banana peels were purchased from a fruit
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Loscalzo, Joseph. "Network Approach to Drug Target Identification and Drug Combinations: Implications for cGMP-based Therapeutics." In cGMP: Generators, Effectors and Therapeutic Implications. ScienceOpen, 2024. http://dx.doi.org/10.14293/cgmp.24000049.v1.

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Enfield, Katey S. S., Erin A. Marshall, Christine Anderson, et al. "Abstract A26: Identification of a novel therapeutic target in lung adenocarcinoma." In Abstracts: Fifth AACR-IASLC International Joint Conference: Lung Cancer Translational Science from the Bench to the Clinic; January 8-11, 2018; San Diego, CA. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1557-3265.aacriaslc18-a26.

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Chengzhang, Li, and Xu Jiucheng. "Identification of Potentially Therapeutic Target Genes in Ovarian Cancer via Bioinformatic Approach." In 2021 IEEE 9th International Conference on Bioinformatics and Computational Biology (ICBCB). IEEE, 2021. http://dx.doi.org/10.1109/icbcb52223.2021.9459203.

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Tomioka, Y., Y. Hagihara, K. Tanigawa, et al. "Identification of Therapeutic Target Molecules for Lung Adenocarcinoma Based on MicroRNA Analysis." In American Thoracic Society 2024 International Conference, May 17-22, 2024 - San Diego, CA. American Thoracic Society, 2024. http://dx.doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a4941.

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T, Suresh, S. Kaliappan, H. Mohammed Ali, and Bura Vijay Kumar. "AI - Driven Drug Discovery and Therapeutic Target Identification for Rare Genetic Diseases." In 2024 International Conference on Advancements in Smart, Secure and Intelligent Computing (ASSIC). IEEE, 2024. http://dx.doi.org/10.1109/assic60049.2024.10507989.

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Hoppe, Stephanie, Jan Winter, Renata Blatnik, et al. "Abstract B31: Identification of target T cell epitopes for a therapeutic HPV16 vaccine." In Abstracts: AACR Special Conference: Tumor Immunology and Immunotherapy: A New Chapter; December 1-4, 2014; Orlando, FL. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/2326-6074.tumimm14-b31.

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Greenblatt, Sarah M., Pierre-Jacques J. Hamard, Takashi Asai, et al. "Abstract 3340: Identification of CARM1/PRMT4 as a novel therapeutic target for AML." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-3340.

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Silvestre, David C., Amelie Brisson, Bérengère Marty-Prouvost, et al. "Abstract B164: Identification and validation of PRMT1 as a therapeutic target in breast cancer." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; November 5-9, 2015; Boston, MA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1535-7163.targ-15-b164.

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Wu, Pei-Yu, Tong-You Wade Wei, Ting-Jung Wu, and Ming-Daw Tsai. "Abstract 3123: Identification of TIFA as a novel therapeutic target in acute myeloid leukemia." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-3123.

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Reports on the topic "Therapeutic target identification"

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Hong, Waun K., and David J. Stewart. PROSPECT (Profiling of Resistance Patterns & Oncogenic Signaling Pathways in Evaluation of Cancers of the Thorax and Therapeutic Target Identification). Defense Technical Information Center, 2008. http://dx.doi.org/10.21236/ada488128.

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Hong, Wuan K. PROSPECT (Profiling of Resistance Patterns & Oncogenic Signaling Pathways in Evaluation of Cancers of the Thorax and Therapeutic Target Identification. Defense Technical Information Center, 2009. http://dx.doi.org/10.21236/ada509995.

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Hong, Wuan K. PROSPECT: Profiling of Resistance Patterns & Oncogenic Signaling Pathways in Evaluation of Cancers of the Thorax and Therapeutic Target Identification. Defense Technical Information Center, 2012. http://dx.doi.org/10.21236/ada581682.

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Allen, J. Rapid Computational Identification of Therapeutic Targets for Pathogens. Office of Scientific and Technical Information (OSTI), 2023. http://dx.doi.org/10.2172/1961765.

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Shiang, Christine. Identification of Novel Therapeutic Targets for Triple-Negative Breast Cancer. Defense Technical Information Center, 2012. http://dx.doi.org/10.21236/ada571316.

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Jongens, Thomas A. Examination of the mGluR-mTOR Pathway for the Identification of Potential Therapeutic Targets to Treat Fragile X. Defense Technical Information Center, 2014. http://dx.doi.org/10.21236/ada612771.

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Shpigel, Nahum Y., Ynte Schukken, and Ilan Rosenshine. Identification of genes involved in virulence of Escherichia coli mastitis by signature tagged mutagenesis. United States Department of Agriculture, 2014. http://dx.doi.org/10.32747/2014.7699853.bard.

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Abstract:
Mastitis, an inflammatory response of the mammary tissue to invading pathogenic bacteria, is the largest health problem in the dairy industry and is responsible for multibillion dollar economic losses. E. coli are a leading cause of acute mastitis in dairy animals worldwide and certainly in Israel and North America. The species E. coli comprises a highly heterogeneous group of pathogens, some of which are commensal residents of the gut, infecting the mammary gland after contamination of the teat skin from the environment. As compared to other gut microflora, mammary pathogenic E. coli (MPEC) m
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Matthews, Lisa, Guanming Wu, Robin Haw, et al. Illuminating Dark Proteins using Reactome Pathways. Reactome, 2022. http://dx.doi.org/10.3180/poster/20221027matthews.

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Diseases are often the consequence of proteins or protein complexes that are non-functional or that function improperly. An active area of research has focused on the identification of molecules that can interact with defective proteins and restore their function. While 22% percent of human proteins are estimated to be druggable, less than fifteen percent are targeted by FDA-approved drugs, and the vast majority of untargeted proteins are understudied or so-called "dark" proteins. Elucidation of the function of these dark proteins, particularly those in commonly drug-targeted protein families,
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