Relevant bibliographies by topics / Therapeutic use of cold

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  3. Books
  4. Book chapters
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Academic literature on the topic 'Therapeutic use of cold'

Author: Grafiati
Published: 4 June 2021
Last updated: 13 February 2022

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Journal articles on the topic "Therapeutic use of cold"

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Hossain, Md Tofazzal, and Md Obydul Hoq. "Therapeutic use of Adhatoda vasica." Asian Journal of Medical and Biological Research 2, no. 2 (August 9, 2016): 156–63. http://dx.doi.org/10.3329/ajmbr.v2i2.29005.

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Adhatoda vasica Nees belonging to family Acanthaceae, commonly known as Adosa, is found many regions of India and throughout the world, with a multitude of uses in traditional Unani and Ayurvedic systems of medicine. It is also called “Vasaka”. It is a well-known herb in indigenous systems of medicine for its beneficial effects, particularly in bronchitis. Vasaka leaves, bark, the root bark, the fruit and flowers are useful in the removal of intestinal parasites. Vasaka herb is used for treating cold, cough, chronic bronchitis and asthma. In acute stages of bronchitis, vasaka gives unfailing relief, especially where the sputum is thick and sticky. It liquefies the sputum so that it is brought up more easily. For relief in asthma, the dried leaves should be smoked. The juice from its leaves should be given in doses of 2 to 4 grams in treating diarrhea and dysentery. A poultice of its leaves can be applied with beneficial results over fresh wounds, rheumatic joints and inflammatory swellings. A warm decoction of its leaves is useful in treating scabies and other skin diseases. In olden times its leaves were made into a decoction with pepper and dried ginger. But the modern medicine searched its active ingredients and found out that vasicine, oxyvascicine and vasicinone are the alkaloids present in vasaka and in which vasicine is the active ingradient for expelling sputum from the body.Asian J. Med. Biol. Res. June 2016, 2(2): 156-163
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Duranceau, Julien, and Michael Mayette. "Use of Cold Fluids in Postcardiac Arrest Therapeutic Hypothermia: A Safety Analysis." Therapeutic Hypothermia and Temperature Management 8, no. 4 (December 2018): 199–202. http://dx.doi.org/10.1089/ther.2017.0052.

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Azevedo, Fernanda Reis de, and Bruno Caramelli. "Hypovitaminosis D and Obesity—Coincidence or Consequence?" US Endocrinology 09, no. 01 (2013): 40. http://dx.doi.org/10.17925/use.2013.09.01.40.

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Vitamin D has attracted much scientific interest in recent years, mostly due to its newly described roles in metabolism regulation and cell proliferation. Along with hypovitaminosis D, the incidence of obesity has risen and has become a public health concern. The association between these two conditions is not merely coincidence and is being deeply investigated regarding its prevalence, mechanism, and even a possible causal relation. The data are still inconclusive but there is important evidence indicating that vitamin D is involved with fat accumulation, the responsible mechanism however still the principal question. The three main hypotheses are: adipose tissue sequestration, genetic modulation, such as polymorphism of the vitamin D receptor (VDR), or an organism evolutionary adaptation to cold weather. In conclusion, more evidence is needed to determine what the correct direction of this connection is and the possible therapeutic strategies of vitamin D replenishment and obesity control.
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Friedman, P. C., V. Miller, G. Fridman, and A. Fridman. "Use of cold atmospheric pressure plasma to treat warts: a potential therapeutic option." Clinical and Experimental Dermatology 44, no. 4 (September 27, 2018): 459–61. http://dx.doi.org/10.1111/ced.13790.

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Winkelman, L., G. E. Sims, M. E. Haddon, D. R. Evans, and J. K. Smith. "A Pasteurised Concentrate of Human Plasma Factor XIII for Therapeutic Use." Thrombosis and Haemostasis 55, no. 03 (1986): 402–5. http://dx.doi.org/10.1055/s-0038-1661573.

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SummaryA therapeutic concentrate of factor XIII containing both A and B sub-units has been prepared from 300 kg pools of human plasma. The process starts from a cold-ethanol fraction from cryoprecipitate supernatant and therefore does not interfere with the recovery of other clinically valuable plasma proteins. Factor XIII is purified approximately 600-fold from plasma by precipitation with sodium citrate and by the removal of fibrinogen by brief heating. The product has been pasteurised in sorbitol solution to inactivate blood-borne viruses, ultrafiltered to remove sorbitol, adsorbed with bentonite and freeze-dried in a formulation meeting requirements for intravenous injection.
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Jwa, Hyeon Seok, Yong Ho Kim, Jaehee Lee, Seung-Keun Back, and Chul-Kyu Park. "Adipose Tissue-Derived Stem Cells Alleviate Cold Allodynia in a Rat Spinal Nerve Ligation Model of Neuropathic Pain." Stem Cells International 2020 (October 12, 2020): 1–7. http://dx.doi.org/10.1155/2020/8845262.

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Neuropathic pain caused by lesions or nervous system dysfunction is a neuroimmune disease with limited therapeutic options. Adipose tissue-derived stem cells (ASCs) are multipotent mesenchymal stem cells with potent immunosuppressive properties, and their use as novel cell-based therapeutics have been proposed in many immune diseases. However, the analgesic effect and efficacy of ASCs to treat neuropathic pain remain unclear. This study, thus, investigated whether ASCs or ASC-derived culture medium can relieve neuropathic pain behaviors (i.e., mechanical and cold allodynia) in a rat model with L5 spinal nerve ligation. Intrathecal injection of ASCs significantly reduced cold allodynia, but not mechanical allodynia. Importantly, cold allodynia was completely reversed in rats with repeated injections of ASCs. In contrast, intrathecal injection of ASC-derived culture medium or retro-orbital injection of ASCs had no effect on neuropathic pain behaviors. These results suggest a novel and alternative therapeutic application of ASCs to target specific neuropathic pain behaviors.
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Knight, John R. P., and Anne E. Willis. "Control of translation in the cold: implications for therapeutic hypothermia." Biochemical Society Transactions 43, no. 3 (June 1, 2015): 333–37. http://dx.doi.org/10.1042/bst20150052.

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Controlled whole-body cooling has been used since the 1950s to protect the brain from injury where cerebral blood flow is reduced. Therapeutic hypothermia has been used successfully during heart surgery, following cardiac arrest and with varied success in other instances of reduced blood flow to the brain. However, why reduced temperature is beneficial is largely unknown. Here we review the use of therapeutic hypothermia with a view to understanding the underlying biology contributing to the phenomenon. Interestingly, the benefits of cooling have recently been extended to treatment of chronic neurodegenerative diseases in two mouse models. Concurrently studies have demonstrated the importance of the regulation of protein synthesis, translation, to the cooling response, which is also emerging as a targetable process in neurodegeneration. Through these studies the potential importance of the rewarming process following cooling is also beginning to emerge. Altogether, these lines of research present new opportunities to manipulate cooling pathways for therapeutic gain.
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Tholpady, Ashok, Arthur W. Bracey, Kelty R. Baker, Ross M. Reul, and Alice J. Chen. "Use of an Intravascular Warming Catheter during Off-Pump Coronary Artery Bypass Surgery in a Patient with Severe Cold Hemagglutinin Disease." Texas Heart Institute Journal 43, no. 4 (August 1, 2016): 363–66. http://dx.doi.org/10.14503/thij-15-5672.

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Cold hemagglutinin disease with broad thermal amplitude and high titers presents challenges in treating cardiac-surgery patients. Careful planning is needed to prevent the activation of cold agglutinins and the agglutination of red blood cells as the patient's temperature drops during surgery. We describe our approach to mitigating cold agglutinin formation in a 77-year-old man with severe cold hemagglutinin disease who underwent off-pump coronary artery bypass surgery without the use of preoperative plasmapheresis. This experience shows that the use of an intravascular warming catheter can maintain normothermia and prevent the activation and subsequent formation of cold agglutinins. To our knowledge, this is the first reported use of this technique in a patient with cold hemagglutinin disease. The chief feature in this approach is the use of optimal thermal maintenance—rather than the more usual decrease in cold-agglutinin content by means of therapeutic plasma exchange.
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Gmernicka, Katarzyna. "Therapeutic effect of systemic cryostimulation." Health Promotion & Physical Activity 1, no. 1 (December 28, 2017): 19–22. http://dx.doi.org/10.5604/01.3001.0010.7583.

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Whole body cryotherapy (WBC) involves exposing individuals to extremely cold dry air (under -100 °C) for a period ranging from 1.5 to 3 minutes. The treatment is painless and is intended to produce and use physiological reaction, which is medically beneficial and effective in restoring normal body functions. Whole body cryotherapy provides various benefits such as: analgesic and anti-inflammatory effects, decreases muscle soreness, improves muscle strength and joint function, boosts blood circulation. It also causes a hormonal reaction, growth of ACTH, cortisol, beta-endorphin and testosterone. Cryotherapy is not only used as a way of treatment but also as a part of wellness and spa. WBC is used prophylactically to improve physical comfort and mental health. It is necessary to use kinesis immediately after cryotherapy to achieve its desirable affects. Kinesitherapy is a 20 minutes set of exercises performed on machines under the guidance of a physiotherapist. The purpose of kinesitherapy is the restoration of normal motion stereotypes, which will prevent overloads.
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Danladi, Jibrin, and Hemmen Sabir. "Perinatal Infection: A Major Contributor to Efficacy of Cooling in Newborns Following Birth Asphyxia." International Journal of Molecular Sciences 22, no. 2 (January 12, 2021): 707. http://dx.doi.org/10.3390/ijms22020707.

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Neonatal encephalopathy (NE) is a global burden, as more than 90% of NE occurs in low- and middle-income countries (LMICs). Perinatal infection seems to limit the neuroprotective efficacy of therapeutic hypothermia. Efforts made to use therapeutic hypothermia in LMICs treating NE has led to increased neonatal mortality rates. The heat shock and cold shock protein responses are essential for survival against a wide range of stressors during which organisms raise their core body temperature and temporarily subject themselves to thermal and cold stress in the face of infection. The characteristic increase and decrease in core body temperature activates and utilizes elements of the heat shock and cold shock response pathways to modify cytokine and chemokine gene expression, cellular signaling, and immune cell mobilization to sites of inflammation, infection, and injury. Hypothermia stimulates microglia to secret cold-inducible RNA-binding protein (CIRP), which triggers NF-κB, controlling multiple inflammatory pathways, including nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasomes and cyclooxygenase-2 (COX-2) signaling. Brain responses through changes in heat shock protein and cold shock protein transcription and gene-expression following fever range and hyperthermia may be new promising potential therapeutic targets.
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Dissertations / Theses on the topic "Therapeutic use of cold"

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Hatzel, Brian M. "Effects of cryotherapy and ankle taping on mechanical power and velocity." Virtual Press, 1999. http://liblink.bsu.edu/uhtbin/catkey/1136705.

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Athletic trainers frequently are required to design rehabilitation and treatment programs for injured athletes. These treatment programs oftentimes involve the use of cryotherapy or ankle taping to create an optimal environment for healing. The purpose of this study was to identify the individual and simultaneous effects of ankle taping and cryotherapy on mechanical power and velocity.Sixteen (16) Division IA Baseball players (Age 20.53+/- 1.15 yrs, Wt 878.45+/105.68 N, Ht 1.85+/- 0.087 m) served as subjects for this study. Subjects met the following criteria: 1) all were asymptomatic from any lower extremity injury for at least six months prior to testing. 2) none had any known cold allergy (ie. hives, hypersensitivity to cold).This study utilized a counterbalanced repeated measures design, in which subjects participated in three treatments, cryotherapy, ankle taping and a combination treatment of cryotherapy and ankle taping. For the taping treatment, each subject was taped using a standard closed basket weave technique` with porous 1.5" cloth athletic tape (Johnson and Johnson, Coach). The cryotherapy treatment was administered a 20 minute ice immersion treatment at 10 deg Celsius to the leg and ankle. In the combination treatment, both treatments were administered with the ice immersion preceding ankle taping. The effects of these treatments on mechanical power and velocity were measured by a Kistler amplifier and force plate platform during a one leg standing vertical jump.The two-way repeated measures ANOVA's for power and velocity showed no significant interaction between cryotherapy, taping or combination treatment. However, significant pre-post treatment effects for power were discovered after cryotherapy and combination treatment. As a result of these findings, it is evident that immediate return to participation after cryotherapy or combination treatment will lead to decreases in muscular performance or injury.
School of Physical Education
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2

Wang, Guofang. "In vitro studies of the effects of hypothermia on lesioned and uninjured mammalian spinal cord neurons." Thesis, University of North Texas, 1991. https://digital.library.unt.edu/ark:/67531/metadc798185/.

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The effects of hypothermia on cultured mammalian (mouse) spinal cord neurons which had been subjected to a defined physical trauma (amputation of a primary dendrite 100μM from the perikaryon) were investigated.
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Poon, Sze-wan, and 潘詩尹. "An evidence-based guideline on using cryotherapy for chemotherapy-induced oral mucositis in adult cancer patients." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48339192.

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Oral mucositis is a common adverse side-effect caused by cancer treatments and can lead to mucosa toxicity. Patients with oral mucositis may experience extreme pain and may not be able to eat, drink and talk and, as a result, their quality of life is impaired. Thirty to eighty five percent of patients undergoing chemotherapy would develop oral mucositis. Preventing or reducing incidence of oral mucositis and its severity can help reduce patients’ sufferings. One of the methods to achieve this objective is the oral cryotherapy, which is a prophylactic intervention. However, there is no evidence-based guideline to instruct nurses on providing oral cryotherapy to cancer patients. The aims of this study are 1) to establish an evidence-based guideline on applying cryotherapy to reduce the incidence and severity of chemotherapy-induced oral mucositis, 2) to develop a standard nursing care and assess its transferability and feasibility, and 3) to develop a communication plan and evaluation plan for this guideline in an oncology ii- department for the targeted local hospitals in Hong Kong. A systematic search of four electronic journal databases identified seven articles corresponding to 6 randomized controlled trials (RCTs) on using oral cryotherapy for adult cancer patients. Five RCTs with high to weak quality reported supporting evidence for the beneficial effect of oral cryotherapy on chemotherapy-induced oral mucositis, whereas 1 RCT with moderate quality failed to identify supportive evidence for the use of oral cryotherapy. However, potential confounding factors were identified to be presented in that insignificant RCT. Hence, there was sufficient evidence to show that oral cryotherapy can significantly reduce chemotherapy-induced oral mucositis in adult cancer patients. An evidence based guideline for using cryotherapy on chemotherapy-induced oral mucositis in adult cancer patients was established. The transferability and feasibility of the proposed oral cryotherapy guideline were assessed. As identified, the clinical situation and patient characteristics in the local settings are similar to those who reported in the reviewed studies. Staff readiness, skills and resources are also readily available in the target clinical settings. Findings from the reviewed studies of oral cryotherapy can be transferred to the local target settings and are feasible to be implemented. It is also estimated that the innovated guidelines for cryotherapy can save HK$3,210,745 per year for the target setting. Stakeholders for the innovated guideline in the local setting were identified. And a communication plan was developed. A pilot study lasting for 10 weeks will be conducted to test the feasibility of the staff training session and the implementation of the oral cryotherapy guideline. Modification of innovated guidelines will be made after evaluating the data collected from the pilot study. Eventually, the final version of the evidence-based guideline will be established. A six months evaluation plan will be used to evaluate the implementation of the new guideline. The policy for adopting the oral cryotherapy will be determined with the outcome measures, including the incidence of chemotherapy-induced oral mucositis, mean of the oral mucositis score, staff satisfaction level, and the cost and benefit ratio of the innovated guideline.
published_or_final_version
Nursing Studies
Master
Master of Nursing
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Lui, Pui-ling, and 呂佩玲. "Evidence-based guidelines of using cryotherapy in reducing pain, knee swelling and improving range of motion for patients after total kneereplacement." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48335939.

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Introduction: Knee osteoarthritis is one of the common causes leading to musculoskeletal disability of the elderly around the world. Total knee replacement (TKR) is an effective and common treatment for end stage knee arthritis. Most papers suggest that early rehabilitation could improve postoperative knee function. However, postoperative pain and local swelling are the complications that diminish range of motion (ROM) and inhibit patients’ recovery. A comprehensive review of the literature reveals that cryotherapy is an effective and safe method to overcome these complications. In this paper, a guideline of using cryotherapy in reducing postoperative pain and knee swelling so as to improve the ROM of patients and promote recovery after TKR has been developed. Objectives: The objectives of this translational research are: (1) to look for relevant papers that related to cryotherapy in reducing postoperative pain and knee swelling so as to improve the ROM of patients after TKR; (2) to gather and criticize the data obtained; (3) to develop a guideline of using cryotherapy in reducing pain, knee swelling and improving ROM of patients after TKR based on the evidence from the reviewed literature; (4) to assess the implementation potential of the newly developed guidelines; and (5) to establish the implementation and evaluation plans for the new innovation. Methods: An empirical literature search published from 2001 to 2011 by several searching engines regarding cryotherapy in reducing postoperative pain and knee swelling with the aim to improve the ROM of patients after TKR has been conducted. After that, the qualities of relevant studies were retrieved and criticized by using the appraisal checklist of the SIGN (2004). The derived evidences were then be summarized and synthesized. An evidence-based guideline was established with reference to the evidence from the reviewed literatures and the results of the quality assessment. Recommendations are graded by SIGN (2004). The implementation potential including transferability, feasibility and cost-benefit ratio of the innovation were assessed as well. Lastly, implementation and evaluation plans have been developed to assess and appraise the effectiveness of the new guideline. Results: Finally, seven studies were chosen as final references after methodological quality assessment. Four main types of comparison were made from these seven reviews including: (1) continuous compressive cryotherapy vs. compressive crepe bandage; (2) comparison in different temperature of cryotherapy; (3) outcome measures; and (4) complications in cryotherapy. After the summary, six main categories of recommendations were synthesized: (1) continuous compression cryotherapy; (2) effective temperature; (3) potential complications; (4) regular assessment; (5) duration; and (6) intermitted ice pack regimen. Based on these syntheses and recommendations, a guideline of using cryotherapy for patients after having TKR was developed. Conclusion: With the implementation of the newly developed evidence-based cryotherapy guidelines for patients after having TKR in local clinical settings, the improvement in the ROM of the knee joint will be anticipated as a result of the reduction in postoperative pain and knee swelling.
published_or_final_version
Nursing Studies
Master
Master of Nursing
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Barry, Simon John. "An investigation into the effectiveness of cryotherapy following total knee replacement." Thesis, Coventry University, 2004. http://curve.coventry.ac.uk/open/items/ca73885a-2912-95ea-d424-c7a5e1c3c06a/1.

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Background: Cryotherapy is commonly used during physiotherapeutic rehabilitation of patients following total knee replacement (TKR). Evidence for treatment effectiveness within the current literature is contradictory and there are no clinical guidelines to inform cryotherapy treatment within this particular patient group. This study surveys current cryotherapy treatment efficacy in the acute post-operative management of TKR patients. Methods: In total 263 senior physiotherapists completed and returned a postal questionnaire, which, using open and closed questions investigated the use of cryotherapy following TKR. Survey results were used to inform a pragmatic randomized clinical trial (RCT) involving 133 consecutive TKR patients. The RCT investigated cryotherapy treatment efficacy in the acute post-operative management of TKR patients. Patients were randomized into three groups; no cryotherapy (NC), delayed cryotherapy (DC) and immediate cryotherapy (IC). The primary outcome measure was post-operative pain with knee swelling, active range of motion (AROM), function and levels of physiotherapy input assessed as secondary outcome measures. Observations were taken pre-operatively and at 3, 7 and 42 days post-operatively. Results: The survey reported that 33% of respondents used some form of cryotherapy routinely following TKR surgery. The two main methods of cryotherapy application were Cryocuff (59%) and crushed ice (30%). Treatments were most frequently applied between 24 hrs and 48 hrs post-surgery for 20 minutes, twice a day. Chi square analysis indicated significant differences (p<0.01) in between NHS and private sites relating to a lack of cryotherapy resources and treatment time for cryotherapy in the NHS. A lack of proven efficacy was the most cited reason for not applying cryotherapy treatment, and swelling the most common treatment indicator. There was particular uncertainty regarding the cleaning and sterilization of the Cryocuff device. The RCT indicated that patients in IC group had significantly less post-operative pain than the NC and DC groups at 3 days. Mean difference (p <0.05, 95% CI) in post-operative analogue scores (VAS, scale 0-10) was -1.6 (p <0.01, CI -2.49- to -0.707) for IC and NC; and -0.922 (p= 0.044, CI -0.183 to -0.009) for IC and DC groups. At 7 and 42 days there were significant reductions in VAS scores for both cryotherapy groups compared to the NC group. There was significant improvement in knee swelling, AROM, ability to transfer and need for additional physiotherapy in both cryotherapy treatment groups although no significant reduction in opiate requirement was found. Conclusions: In current clinical practice there was little consensus regarding treatment indicators, method of application and management of cryotherapy following TKR. However, in a RCT the use of cryotherapy combined with compression, as compared to a no cryotherapy control, led to significant reductions in patient reported pain, less post-operative swelling, greater recovery of AROM, faster return of function and less reliance on OPD physiotherapy treatment. It is concluded that cryotherapy combined with compression has an important role to play in the acute rehabilitation of TKR and should be considered as part of routine management.
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Lü, Fengjuan, and 吕凤娟. "Potential of bone marrow and umbilical cord derived mesenchymal stem cells in intervertebral disc repair." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48079753.

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Introduction: Intervertebral disc (IVD) degeneration is suggested to begin from the nucleus pulposus (NP). Evidence from various studies highlights mesenchymal stem cells (MSC), in most cases using bone marrow derived MSC, as a potential stem cell source for NP regeneration. However MSC can be isolated from many sources with various characteristics. There are indications that fetal or close to fetal tissue sources contain MSC with relatively undifferentiated phenotype with respect to MSC from adult sources. Moreover, umbilical cord (C)-MSC may have better chondrogenic differentiation potential than bone marrow (B)-MSC. We hypothesize CMSC are different from BMSC, and more efficient than BMSC in stimulating NP regeneration. Methods: MSC were isolated from human bone marrow and umbilical cord with corresponding ethical approval. BMSC and CMSC were characterized for cell surface marker expression profile and differentiation potential.. RT-PCR of interest genes in NP cells isolated from scoliosis and degenerate discs was performed to search for NP degeneration indicators. Conditioned media (CM) was collected from confluent MSC monolayer, and used for stimulation of four batches of degenerated NP cells isolated from human degenerative intervertebral discs. Cell proliferation and cytotoxicity were assessed by MTT assay. Proteoglycan content were measured by DMMB assay. Gene expression of a series of degeneration related molecules including ACAN, SOX9, CDH2, CD55, KRT19, KRT18, FBLN1 and MGP, and fibrosis related molecules, including MMP12, HSP47, COL1A1, COL3A1 and FN1, of NP cells in MSC-CM were determined by real- time RT-PCR. All results were normalized to the control cells in basal medium. The expression of discogenic, chondrogenic and osteogenic markers on BMSC and CMSC were compared by RT-PCR. Results and Conclusion: CMSC were similar to BMSC and fulfilled the minimum criteria of MSC, however the expression of CD146, CD106 and Stro-1 was different, and BMSC had a spontaneous osteogenesis tendency while CMSC expressed chondrogenic marker even without TGF-beta stimulation. BMSC demonstrated a paracrine effect on modulating human degenerated NP cells towards a non-degenerative phenotype in stimulating cell proliferation, slightly enhancing proteoglycan production, upregulating KRT19 while downregulating MMP12. Compared with BMSC, a higher paracrine effect of CMSC was disclosed in modulating the phenotype of NP cells in all aspects tested, and an intrinsic higher expression on CMSC of ‘potential NP markers’, including KRT19, KRT18 and CD55, but lower expression of osteogenic markers, including RUNX2 and ALPL, was revealed, which indicate a higher potential of CMSC for future clinical application to treat IVD degeneration diseases. KRT19 and MMP12 were also confirmed to be the highest differentially expressed candidate genes between cultured scoliosis and degenerated human NP cells, indicating a high indicator potential of NP degeneration. Furthermore, a subpopulation was detected in the degenerated NP cells that possessed macrophage-like phenotype and activities, which may play a role in the pathogenesis of IVD degeneration. In conclusion, studies in this thesis highlighted CMSC as a superior source than BMSC for IVD repair. Further investigations into the active agents in the conditioned media and the signalling pathway may help to elucidate the mechanism of the effect.
published_or_final_version
Orthopaedics and Traumatology
Doctoral
Doctor of Philosophy
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Medina, Balbuena Sara [Verfasser], and Benito [Akademischer Betreuer] Yard. "The use of stem cells as a therapeutic modality for amelioration of chronic renal damage after warm or cold ischaemic insults / Sara Medina Balbuena ; Betreuer: Benito Yard." Heidelberg : Universitätsbibliothek Heidelberg, 2021. http://d-nb.info/1227585543/34.

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Medina, Balbuena Sara [Verfasser], and Benito A. [Akademischer Betreuer] Yard. "The use of stem cells as a therapeutic modality for amelioration of chronic renal damage after warm or cold ischaemic insults / Sara Medina Balbuena ; Betreuer: Benito Yard." Heidelberg : Universitätsbibliothek Heidelberg, 2021. http://nbn-resolving.de/urn:nbn:de:bsz:16-heidok-292709.

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Wong, Po-shan Susan, and 黃寶珊. "The Buddha Dhamma as a psychotherapeutic technique and how the Buddhist mindfulness practice could be integrated into thecontemporary social work service." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B48521784.

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This doctrinal study demonstrates in what way the ‘Universal Applicability’ of Buddha Dhamma can be reflected in the intervention process in view of the contemporary situation of the Buddhist Mindfulness being integrated as a psychotherapeutic technique. In past few decades, the Western psychotherapists recognize Mindfulness as ‘the heart of Buddhist meditation’ and apply it as an impartial psychotherapeutic technique to serve their clients’ physical health and psychological wellness. As recorded in the Buddhist Pāli tradition, through practicing Mindfulness meditation, people are able to comprehend the ‘Universal Applicability’ of Buddha Dhamma, to realize three universal characteristics (lakkhanas) of sentient existence, namely impermanence (anicca), un-satisfactoriness (dukkha), and non-self (anatta), and eventually to liberate their mind from suffering. From studying the Buddhist teaching of Mindfulness embedded in the Satipaṭṭhāna Sutta and the Mahā-Satipaṭṭhāna Sutta, the researcher develops this tenet, “the Buddhist Mindfulness could be an effective psychotherapeutic technique when it is practiced within the Buddhist context and supported by the theoretical foundation, and when the ‘Universal Applicability’ of the Buddha Dhamma is reflected in the therapeutic process ”. Applying the tenet to study the case, the ‘Mindfulness-Based Stress Reduction Program’ (the MBSR) initiated by Dr. Jon Kabat-Zinn, she finds three issues which makes her hesitated to agree with the Western psychotherapists’ integrating the Buddhist Mindfulness as a stand-alone psychotherapeutic technique. The first two issues are the way the psychotherapists interpreting and implementing the Buddhist Mindfulness as a stand-alone technique without the Buddhist context and isolated from the Buddhist theoretical foundation. Resulted from the first two issues, the third one is the ‘Universal Applicability’ of Buddha Dhamma has no way to reflect in the treatment process to help people liberating from suffering. After identifying these three issues, the researcher carries on to incorporate ideas of practicing Mindfulness suggested by the Pali Buddhist tradition, and collaborate with the Social Work Profession with applying transferrable skills of the ‘Experiential Learning’ techniques to design a pilot service—the Buddhist Mindfulness-Based Social Service Project (the BMBSS). The BMBSS, consists of (1) an Orientation Meeting, (2) the six-session Prerequisite Training (the PRT-BMBSS) and, (3) the twenty-six-session Buddhist Mindfulness-Based Social Service Program (the BMBSS), aims at demonstrating the way to support the ‘Practicing Facilitators’ and the ‘Practicing Novices’ to apply the Buddhist teaching of Mindfulness into their daily activities. Moreover, the researcher designs the BMBSS Project in the way to promote interdisciplinary collaboration between Buddhist communities and the Social Work Profession to exchange ideas to benefit their services. The Social Work Profession may benefit from the Buddhist teaching on ‘non-self’ to apply its intrinsic technique of the ‘use of self’ to serve the clients, when the Buddhist communities may learn from the Social Work Profession to bring the Buddhist teaching to serve the society at large. Furthermore, ideas on supporting inter-disciplinary collaboration generated from developing the BMBSS may transfer into promoting dialogues and networking between the Buddhist communities and other professions to integrate the ‘Universal Applicability’ of Buddha Dhamma to serve the needs of the Buddhists and non-Buddhists.
published_or_final_version
Buddhist Studies
Doctoral
Doctor of Philosophy
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10

Van, Tubbergh Karen. "Skeletal muscle repair after micro-damage : effect of ice therapy on satellite cell activation." Thesis, Stellenbosch : University of Stellenbosch, 2005. http://hdl.handle.net/10019.1/16623.

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Thesis (MSc)--University of Stellenbosch, 2005.
ENGLISH ABSTRACT: Cryotherapy is one of the popular treatments used to alleviate muscle soreness, especially in the competitive sports arena. However, the therapeutic use of cryotherapy is unsubstantiated because of a lack of proper investigations in the literature, especially a hypothesised effect on muscle recovery. Thus, our aims were to characterise satellite cell (SC) activity in human subjects with delayed onset muscle soreness (DOMS) and to shed light on the effect of cryotherapy on SC activity. DOMS was induced in six male subjects (24 ± 3 years) by completion of a downhill-run (DHR) protocol (5 x 8 min bouts, 2 min rest between bouts) at 70 or 80% of their individual peak treadmill speed. Ice application was applied to only one leg per subject for 3 days: 30 min every 2 hours, 5 times per day. In total 5 muscle biopsies were obtained from each subject: 1 baseline and 4 post-DHR. Post-DHR biopsies: 1 from each leg on day 1 and 7 (1st group, n=3) and 1 from each leg on day 2 and 9 (2nd group, n=3). DOMS was successfully induced as indicated by significant increases in muscle soreness at days 1 and 2 post-DHR (P < 0.01), and creatine kinase activity at day 1 post-DHR (P < 0.01). No difference in muscle soreness was found between treated and untreated legs. SC quiescence and activation were characterised by their expression of the cell surface markers CD34 and CD56 respectively. No significant change in quiescent SC was observed in the untreated or treated legs over time. However, at day 1 post-DHR the number of quiescent SC was significantly lower in the untreated compared with the treated leg (P < 0.05). There was a significant increase in activated SC numbers at day 2 post-DHR in the untreated leg, which was sustained up to day 9 post-DHR (P < 0.01). However, no such increase was found in biopsies taken on days 1 and 7. Also, no change was found in the treated leg, however a significant difference between the number of activated SC in untreated and treated legs on days 2 and 9 post-DHR (P < 0.01) was seen. No significant effect of DOMS or ice treatment was observed for the expression of the myogenic regulatory factors, MyoD and myogenin. C2C12 cell cultures induced to differentiate, however, did stain using these antibodies. This is the first study to report an effect of cryotherapy at the tissue level. In conclusion, this study highlights many unanswered questions on the SC response to DOMS at tissue level, and lays a good foundation for future studies.
AFRIKAANSE OPSOMMING: Kreoterapie is een van die gewilde behandelings wat gebruik word om spierseerheid te verlig, veral in die kompeterende sport arena, maar die gebruik van kreoterapie is onbevestig as gevolg van ‘n gebrek aan voldoende ondersoeke in die literatuur, veral ‘n hipotese oor die effek op spier-herstel. Ons doelstellings was dus om satellietsel (SC) aktiwiteit te ondersoek in mens proefpersone met vertraagde aanvang spierseerheid (DOMS) en ook om lig te werp op die effek van kreoterapie op SC aktiwiteit. DOMS was in ses mans proefpersone (24 ± 3 jare) geїnduseer deur voltooїng van ‘n afdraend-hardloop (DHR) protokol (5 x 8 min rondtes, 2 min rus tussen rondtes) teen 70 of 80% van elkeen se individuele maksimum trapmeul-spoed. Ys was vir 3 dae op net een been per proefpersoon aangewend: 30 min elke 2 ure, 5 keer per dag. 5 spierbiopsies in totaal was van elke proefpersoon verkry: 1 basislyn en 4 post-DHR. Post-DHR biopsies: 1 van elke been op dae 1 en 7 (1ste groep, n=3) en 1 van elke been op dae 2 en 9 (2de groep, n=3). DOMS was suksesvol geїnduseer soos aangedui deur die betekenisvolle verhogings in spierseerheid op dae 1 en 2 post-HR (P < 0.01) en kreatien kinase aktiwiteit op dag 1 post-DHR (P < 0.01). Geen verskil in spierseerheid is gevind tussen die onbehandelde en behandelde bene nie. SC dormansie en aktivering was gekarakteriseer deur die onderskeidelike uitdrukking van die sel oppervlak merkers CD34 en CD56. Geen betekenisvolle verandering is in SC dormansie in die onbehandelde en behandelde bene waargeneem nie, maar op dag 1 post-DHR was die getal dormante SC betekenisvol laer in die onbehandelde been as in die behandelde been (P < 0.05). Daar was ‘n betekenisvolle verhoging in die getalle geaktiveerde SC op dag 2 post-DHR in die onbehandelde been wat volgehou was tot op dag 9 post-DHR (P < 0.01), maar so ‘n verhoging was nie in biopsies wat op dae 1 en 7 geneem is gevind nie. Daar is ook geen verandering in die behandelde been gevind nie, maar ‘n betekenisvolle verskil in die getal geaktiveerde SC is tussen die onbehandelde en behandelde bene op dae 2 en 9 post-DHR gevind(P < 0.01). Geen betekenisvolle effek van DOMS en ys-aanwending vir die uitdrukking van die miogeniese (myogenic) regulatoriese faktore, MyoD en myogenin, is waargeneem nie. C2C12 sel kulture wat geїnduseer is om te differensieer het wel gekleur vir hierdie antiliggame. Dit is die eerste studie wat ‘n effek van kreoterapie op weefselvlak rapporteer. Ten slotte, hierdie studie beklemtoon baie onbeantwoorde vrae oor die SC respons op DOMS op weefselvlak en dit lê ‘n goeie grondslag neer vir toekomstige studies.
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Books on the topic "Therapeutic use of cold"

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Knight, Kenneth L. Cryotherapy: Theory, technique and physiology. Chattanooga, Tenn: Chattanooga Corp., 1985.

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Garmāʹdarmānī va sarmāʹdarmānī. Iṣfahān: Mujtabá Rafīʻī, bā hamkārī-i Shirkat-i Ātarpāt, 1996.

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Eby, George A. Handbook for curing the common cold: The zinc lozenge story. Austin, Tex: G. Eby Research, 1994.

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Byers, Dorie. Growing herbs for cold & flu relief. Pownal, Vt: Storey Books, 1999.

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Castelán, Guillermo Mendoza. Lo frío y lo caliente en la medicina tradicional. Chapingo, México: Universidad Autónoma Chapingo, Departamento de Fitotecnia, Programa Universitario de Medicina, Tradicional y Terapéutica Naturista, 2003.

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Scionti, Stephen. Aiming at life: Targeting ice against prostate cancer. Bloomington, IN: AuthorHouse, 2008.

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Gan mao shi pu: Recipe when you catch cold. Taibei Shi: Er yu wen hua shi ye you xian gong si, 2004.

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Mars, Brigitte. Elder: The amazing healing benefits of elder, the premier herbal remedy for colds and flu. New Canaan, Conn: Keats Pub., 1997.

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Frontiers in cord blood science. London: Springer, 2009.

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David, Hoffmann. Easy breathing: Natural treatments for asthma, colds, flu, coughs, allergies, sinusitis. Pownal, Vt: Storey Books, 2000.

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Book chapters on the topic "Therapeutic use of cold"

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Van Pham, Phuc, and Ngoc Kim Phan. "Production of Good Manufacturing Practice-Grade Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells for Therapeutic Use." In Methods in Molecular Biology, 73–85. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/7651_2014_125.

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Bossi, Paolo, and Luigi Lorini. "Optimal Supportive Measures during Primary Treatment." In Critical Issues in Head and Neck Oncology, 221–30. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-63234-2_15.

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AbstractSupportive care during curative treatment of head and neck cancer patients has different scopes: reducing the burden of acute toxicities and limiting the risk of developing late adverse effects; increasing the quality of life of the patients; allowing to perform optimal curative therapy, maintaining treatment dose intensity; preventing higher grade toxicities so to reduce also the costs associated with hospitalization, examinations, visits and use of drugs. At the same time, it is necessary to give uniformity in the supportive care protocols, as these preventive and therapeutic measures may influence the results of oncological treatments and their efficacy should be evaluated in a consistent manner. Several preventive and therapeutic interventions are available, particularly in the context of chemoradiotherapy, where the adverse events are more prominent. An accurate evaluation of the patient and a tailored approach with preventative indications and therapeutic interventions represent key factors. This approach could be easily identified within a “simultaneous care” strategy, as the optimal supportive measures are provided concurrently to the best therapeutic approach since the beginning of the treatment.
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Read, Daniel, James Skinner, Daniel Lock, and Aaron CT Smith. "Therapeutic use exemptions." In WADA, the World Anti-Doping Agency, 102–23. First. | Milton Park, Abingdon, Oxon ; New York NY : Routledge, 2021. | Series: Routledge research in sport and corruption: Routledge, 2021. http://dx.doi.org/10.4324/9781003084297-6-6.

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Basford, Jeffrey R. "Therapeutic Heat, Microwaves, and Cold." In Encyclopedia of Pain, 3939–43. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-28753-4_4470.

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Kenealy, Timothy W., and Bruce Arroll. "Antibiotic use for common cold." In Commond Cold, 237–47. Basel: Birkhäuser Basel, 2009. http://dx.doi.org/10.1007/978-3-7643-9912-2_11.

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Ganier, Clarisse, and Sonia Gaucher. "Emerging Technologies in Scar Management: The Role of Allogeneic Cells." In Textbook on Scar Management, 451–55. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-44766-3_51.

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AbstractScars caused by burns, chronic ulcers from diabetes, infections, skin cancer surgery, and other genetic or somatic disease could require effective treatment to avoid functional and psychological troubles and even mortality. Most of the current treatments aim to reduce local inflammation but not to prevent scarring. Herein, we discussed about emerging technologies in scar management using allogeneic cell therapy. The industrialised allogeneic cell therapy products and the clinical trials using keratinocytes, fibroblasts or MSCs demonstrated acceleration of skin cell migration and proliferation, control wound scarring, immunomodulatory properties and improved angiogenesis. In addition, allogeneic cell transplants offered the possibility of large pre-fabrication, cryo-preservation, for instantaneous use and repeated applications. Current research exploring allogeneic cell therapies for scar treatment are focusing on grafting of epidermal sheets, cellular dermal substitutes and reconstructed skin equivalent and cell intradermal injections. Advances in knowledge in therapeutic potentials of allogeneic injected cells give rise to new therapeutic approaches such as administration of allogeneic cell-derived extracellular vesicles.
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Lanzotti, Virginia. "Diterpenes for Therapeutic Use." In Natural Products, 3173–91. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-22144-6_192.

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Wiltenburg, Victor Distefano, Dianne da Rocha Prado, and Fúlvio Rieli Mendes. "Therapeutic Use of Hallucinogens." In Drugs and Human Behavior, 479–510. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-62855-0_35.

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Aranki, S. F., F. Mannting, S. K. Shernan, N. C. Cummings, S. P. Sears, and L. H. Cohn. "Transmyocardial Laser Use for Endstage Coronary Artery Disease." In Therapeutic Angiogenesis, 163–73. Berlin, Heidelberg: Springer Berlin Heidelberg, 1999. http://dx.doi.org/10.1007/978-3-662-03776-8_9.

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Chugh, Atul R., Samir N. Patel, Venkataraman Rajaram, Rachel Neems, Matt Feinstein, Marshall Goldin, and Steven B. Feinstein. "The Clinical Use of Noninvasive Modalities in the Assessment of Atherosclerosis." In Therapeutic Lipidology, 389–408. Totowa, NJ: Humana Press, 2007. http://dx.doi.org/10.1007/978-1-59745-533-6_18.

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Conference papers on the topic "Therapeutic use of cold"

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Franklin, Maryland Rosenfeld, David Draper, Sumithra Urs, and Scott Wise. "Abstract 535: Preclinical use of focal radiation and immune checkpoint blockade to improve therapeutic response in an immunologically cold tumor." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-535.

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Franklin, Maryland Rosenfeld, David Draper, Sumithra Urs, and Scott Wise. "Abstract 535: Preclinical use of focal radiation and immune checkpoint blockade to improve therapeutic response in an immunologically cold tumor." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-535.

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Khoshnevis, Sepideh, Natalie Craik, and Kenneth R. Diller. "Cryotherapy Modification to Overcome Uninterrupted Ischemia." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14423.

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Localized cooling is commonly used following orthopedic surgery and in sports medicine to reduce swelling, pain, inflammation, metabolism, muscle spasm, and bleeding[1,2]. The therapeutic application of cold therapy has a long history dating from the time of Hippocrates and has been widely documented in the literature[3,4]. Nonetheless, there remains to the present time considerable controversy over the appropriate protocol for application of cryotherapy and the risk factors associated with its use[5].
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Ort, Teddy, Faye Wu, Nicholas C. Hensel, and H. Harry Asada. "Supernumerary Robotic Fingers as a Therapeutic Device for Hemiparetic Patients." In ASME 2015 Dynamic Systems and Control Conference. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/dscc2015-9945.

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Patients with hemiparesis often have limited functionality in the left or right hand. The standard therapeutic approach requires the patient to attempt to make use of the weak hand even though it is not functionally capable, which can result in feelings of frustration. Furthermore, hemiparetic patients also face challenges in completing many bimanual tasks, for example walker manipulation, that are critical to patients’ independence and quality of life. A prototype therapeutic device with two supernumerary robotic fingers was used to determine if robotic fingers could functionally assist a human in the performance of bimanual tasks by observing the pose of the healthy hand. Specific focus was placed on the identification of a straightforward control routine which would allow a patient to carry out simple manipulation tasks with some intermittent input from a therapist. Part of this routine involved allowing a patient to switch between active and inactive monitoring of hand position, resulting in additional manipulation capabilities. The prototype successfully enabled a test subject to complete various bimanual tasks using the robotic fingers in place of normal hand motions. From these results, it is clear that the device could allow a hemiparetic patient to complete tasks which would previously have been impossible to perform.
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Khoshnevis, Sepideh, Daniel W. Hensley, and Kenneth R. Diller. "Measurement and Analysis of Cutaneous Perfusion Depression During Cryotherapy." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53853.

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Localized cooling is commonly used after orthopedic surgery and in sports medicine to reduce bleeding, inflammation, metabolism, muscle spasm, pain, and swelling following musculoskeletal trauma and injury. The therapeutic application of cold therapy has a long history dating from the time of Hippocrates and has been widely documented in the literature1–3. Nonetheless, there remains to the present time considerable controversy over the appropriate protocol for application of cryotherapy. One extreme camp advocates continuous use of cryotherapy to a treatment site with no break in cooling for days or even weeks4–5, whereas other practitioners recommend a maximum application duration of 20 to 30 minutes followed by a cessation period of about 2 hours6–7. Although continuous cooling appears to be tolerated by many patients, there has been a large number of reported incidences in which continuous application of cryotherapy device led directly to extensive tissue necrosis and/or nerve injury in the treatment area, sometimes with dire medical consequences6,8.
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Al-Asmar, Jawaher, Sara Rashwan, and Layla Kamareddine. "The use of Drosophila Melanogaster as a Model Organism to study the effect of Bacterial Infection on Host Survival and Metabolism." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0186.

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Enterobacteriaceae, a large family of facultative anaerobic bacteria, encloses a broad spectrum of bacterial species including Escherichia coli, Salmonella enterica, and Shigella sonnei, that produce enterotoxins and cause gastrointestinal tract diseases. While much is known about the regulation and function of enterotoxins within the intestine of the host; the lack of cheap, practical, and genetically tractable model organisms has restricted the investigation of others facets of this host-pathogen interaction. Our group, among others, has employed Drosophila melanogaster, as a model organism to shed more light on some aspects of host-pathogen interplays. In this project, we addressed the effect of Escherichia coli, Salmonella enterica, and Shigella sonnei infection on altering the metabolic homeostasis of the host. Drosophila melanogaster flies were orally infected with Escherichia coli, Salmonella enterica, or Shigella sonnei, a method that mimics the natural route used by enteric pathogens to gain access to the gastrointestinal tract in humans. The results of our study revealed that both Escherichia coli and Shigella sonnei pathogens were capable of colonizing the host gut, resulting in a reduction in the life span of the infected host. Escherichia coli and Shigella sonnei infected flies also exhibited altered metabolic profiles including lipid droplets deprivation from their fat body (normal lipid storage organ in flies), irregular accumulation of lipid droplets in their gut, and significant elevation of systemic glucose and triglyceride levels. These metabolic alterations could be mechanistically attributed to the differential down-regulation in the expression of metabolic peptide hormones (Allatostatin A, Diuretic hormone 31, and Tachykinin) detected in the gut of Escherichia coli and Shigella sonnei infected flies. Salmonella enterica; however, was unable to colonize the gut of the host; and therefore, Salmonella enterica infected flies exhibited a relatively normal metabolic status as that of non infected flies. Gaining a proper mechanistic understanding of infection-induced metabolic alterations helps in modulating the pathogenesis of gastrointestinal tract diseases in a host and opens up for promising therapeutic approaches for infection induced metabolic disorders
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Huang, Zhongping, Ying Jin, Saeed Tarabichi, Yifan Zhang, Itzhak Fischer, and Liang Zhu. "Study of Hypothermia Induced by an Interstitial Cooling Device in Spinal Cord Injury." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80282.

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Previous studies have suggested that systemic hypothermia shortly following an ischemic or traumatic event to the spinal cord provided significant beneficial effects following spinal cord injury (SCI)1–3. There are two strategies for hypothermia treatment, a systemic and a local cooling. Both strategies have shown neuro-protective effects of SCI in experimental animal models and in patients; however, there is a variety of technical quandaries when applying this principal to the clinical setting, such as the use of special cooling equipment and the special surgery required to functionally implementing them. We are also concerned with the non-uniform cooling rates in the spinal cord and potential risks associated with each procedure. It is important to develop novel cooling methods to reach desired therapeutic effects while ensuring patient safety.
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Eldor, A., M. Bar-Ner, L. Wasserman, Y. matzner, Z. Fuks, and I. Viodavsky. "HEPARIN AND NON-ANTICOAGULANT HEPARINS INHIBIT HEPARANASE ACTIVITY IN NORMAL AND MALIGNANT CELLS:POSSIBLE THERAPEUTIC USE IN PREVENTION OF EXTRAVASATION AND DISSEMINATION OF BLOOD BORNE CELLS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643664.

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Degradation of vascular subendothelium occurs in_vivo during the process of inflammation and tumor invasion. Various observations suggest that the capacity of some blood-borne cells to extravasate may depend in part on their ability to express hepara-nase activity. Incubation of human platelets, human nc-utrophils, or highly metastatic mouse lymphoma cells with sulfate-labeled extracellular matrix (ECM) results in heparanase mediated release of labeled heparan sulfate cleavage fragments (0.5<Kav<0.85 on Sepharose 5B) (J. Clin.Invest. 74: 1842 and 76: 1306; Cancer Res. 43: 2704). The present study was undertaken to test the heparanase inhibitory effect of heparin and non-anticoagulant species of heparin that might havea potential therapeutic use in preventing heparanase mediated extravasation ofblood-borne cells. We prepared totallyor N-desulfated heparins which were either left with their N-position exposed or were subsequently N-acetylated or N-resulfated. These heparins exhibited less than 5% of the anticoagulant activityof native heparin. It was found that total desulfation of heparin abolished its heparanase inhibitory activity whether desulfation was followed by N-acetylation or not. Inhibitory effect was restored by resulfation of the N-position. When only the N-sulfate group was desulfated, inhibitory activity was lost but could be restored by acetylation of the N-position. These results indicate that N-sulfate groups of heparin are necessary for its heparanase inhibitory activity but can be substituted by an acetyl group provided that the 0-sulfate groups are retained. Low Mr heparins (main Mr species of 2500 and 4500 daltons) and heparin fragments as small as the tetrasaccharide inhibited degradation of heparan sulfate in the ECM, albeit to a lower extent than native heparin. Similar effects of the different heparins were observed with heparanase activities from platelets, neutrophils and lymphoma cells. Preliminary in vivo experiments suggest that non-anticoagulant heparins interfere with tumor metastasis and experimental autoimmune diseases (some heparins were kindly provided by Inst. Choay, Paris and Kabi Vitrum, Stockholm).
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Whitney, Jon, Jianfe Zhang, Harry Dorn, Tom Campbell, Sayan Naha, and Marissa Nichole Rylander. "Carbon Nanotube Peapod-Mediated Laser Cancer Therapy." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206786.

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Development of dual diagnostic and therapeutic agents for cancer with heightened sensitivity, selectivity, and lower toxicity could greatly enhance the prognosis of patients suffering from this disease. Recent work by Dr. Harry Dorn of Virginia Tech has resulted in the creation of a novel nanostructure called a carbon nanotube peapod. This structure consists of multiple TNT EMF’s (Trimetallic nitride template endohedral metallofullerenes) contained within a single-walled carbon nanotube (CNT) in the form of a peapod. Using TNT EMFs containing gadolinium, this nanostructure can achieve a 40-fold improvement in magnetic resonance imaging (MRI) contrast enhancement [1]. The CNT component of the peapod can be utilized as a hyperthermia enhancer [2] and an effective platform for drug delivery [3]. This study focuses on the use of carbon nanotube peapods (CNT peapods) to absorb near infrared light and generate therapeutic heat for tumor destruction. With sufficient heating and nanoparticle targeted delivery to tumor cells, CNT peapods can potentially induce selective hyperthermia-mediated toxicity in tumors.
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Smith, Katisha D., and Liang Zhu. "Theoretical Evaluation of a Simple Cooling Pad Inducing Hypothermia in the Spinal Cord Following Traumatic Injury." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206190.

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Although significant damage is caused by the mechanics of the traumatic spinal cord injury (SCI), secondary injury that follows is often times even more dangerous. It occurs within the first 12–24 hours following the injury and can last up to 5–10 days, depending on the severity of the injury [1]. Secondary injury causes physiological disturbances that disrupt the body’s homeostasis like initiating a cellular inflammatory response at the injury site and increasing the release of free radicals. An overabundance of free radicals contributes to tissue ischemia, cerebral edema, and disruption of the spine-blood barrier. The use of hypothermia (<35°C) as a therapeutic agent has been shown effective in providing neuroprotection from secondary injury [2]. Research has shown the benefits of hypothermia include decreasing oxygen consumption, free radical generation, neurotransmitter release, inflammation, and metabolic demands [3–5]. Even a temperature decrease of 1–2°C can be beneficial at the cellular level [4,6]. However, these studies use techniques that can be invasive. This research evaluates the effectiveness of using a non-invasive cooling pad on the torso to reduce the spinal cord temperature by at least 2°C.
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Reports on the topic "Therapeutic use of cold"

1

Lelievre, Sophie A. The Use of a Human Breast Tumor Progression Series and a 3-D Culture Model to Determine if Nuclear Structure Could Provide a Molecular and Therapeutic Marker. Fort Belvoir, VA: Defense Technical Information Center, October 1998. http://dx.doi.org/10.21236/adb248428.

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Evans, Holly. The Use of Filariae as a Therapeutic Agent for Hypersensitivity Diseases. Fort Belvoir, VA: Defense Technical Information Center, November 2014. http://dx.doi.org/10.21236/ad1012825.

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ENGELMAN, D. B. Cold Vacuum Drying (CVD) Facility Acceptance for Beneficial Use. Office of Scientific and Technical Information (OSTI), October 2000. http://dx.doi.org/10.2172/805410.

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BRISBIN, S. A. Cold Vacuum Drying (CVD) Facility Acceptance for Beneficial Use. Office of Scientific and Technical Information (OSTI), January 2000. http://dx.doi.org/10.2172/801160.

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Lillo, Antonietta. Harnessing in vitro evolution to discover antibodies for therapeutic and diagnostic use. Office of Scientific and Technical Information (OSTI), March 2021. http://dx.doi.org/10.2172/1773320.

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Baldi, Emilio. The Use of Extremely Low Frequencies (ELF) in Pulsed Form (PELF) for Therapeutic Use: A Pilot Study. Fort Belvoir, VA: Defense Technical Information Center, October 2001. http://dx.doi.org/10.21236/ada409410.

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Templeton, Charles B., Mark A. Poli, and Rikki Solow. Prophylactic and Therapeutic Use of an Anti-Brevetoxin (PbTx-2) Antibody in Conscious Rats. Fort Belvoir, VA: Defense Technical Information Center, May 1988. http://dx.doi.org/10.21236/ada210932.

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Welch, K. M., L. A. Smart, and R. J. Todd. Enhanced Ignition of Cold Cathode Gauges Through the Use of Radioactive Isotopes. Office of Scientific and Technical Information (OSTI), November 1995. http://dx.doi.org/10.2172/1119390.

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Van Noord, Jon, Brian Gilchrist, Roy Clarke, Pedro A. Encarnacion, and Hannah Goldberg. The Use of Boron Nitride for Improved Cold-Cathode Electron Field Emission Technology. Fort Belvoir, VA: Defense Technical Information Center, May 2004. http://dx.doi.org/10.21236/ada426331.

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Mejias-Santiago, Mariely, Franciso del Valle-Roldan, and Lucy P. Priddy. Certification Tests on Cold Patch Asphalt Repair Materials for Use in Airfield Pavements. Fort Belvoir, VA: Defense Technical Information Center, June 2010. http://dx.doi.org/10.21236/ada523874.

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