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1
Hatzel, Brian M. "Effects of cryotherapy and ankle taping on mechanical power and velocity." Virtual Press, 1999. http://liblink.bsu.edu/uhtbin/catkey/1136705.
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Athletic trainers frequently are required to design rehabilitation and treatment programs for injured athletes. These treatment programs oftentimes involve the use of cryotherapy or ankle taping to create an optimal environment for healing. The purpose of this study was to identify the individual and simultaneous effects of ankle taping and cryotherapy on mechanical power and velocity.Sixteen (16) Division IA Baseball players (Age 20.53+/- 1.15 yrs, Wt 878.45+/105.68 N, Ht 1.85+/- 0.087 m) served as subjects for this study. Subjects met the following criteria: 1) all were asymptomatic from any lower extremity injury for at least six months prior to testing. 2) none had any known cold allergy (ie. hives, hypersensitivity to cold).This study utilized a counterbalanced repeated measures design, in which subjects participated in three treatments, cryotherapy, ankle taping and a combination treatment of cryotherapy and ankle taping. For the taping treatment, each subject was taped using a standard closed basket weave technique` with porous 1.5" cloth athletic tape (Johnson and Johnson, Coach). The cryotherapy treatment was administered a 20 minute ice immersion treatment at 10 deg Celsius to the leg and ankle. In the combination treatment, both treatments were administered with the ice immersion preceding ankle taping. The effects of these treatments on mechanical power and velocity were measured by a Kistler amplifier and force plate platform during a one leg standing vertical jump.The two-way repeated measures ANOVA's for power and velocity showed no significant interaction between cryotherapy, taping or combination treatment. However, significant pre-post treatment effects for power were discovered after cryotherapy and combination treatment. As a result of these findings, it is evident that immediate return to participation after cryotherapy or combination treatment will lead to decreases in muscular performance or injury.School of Physical Education
2
Wang, Guofang. "In vitro studies of the effects of hypothermia on lesioned and uninjured mammalian spinal cord neurons." Thesis, University of North Texas, 1991. https://digital.library.unt.edu/ark:/67531/metadc798185/.
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The effects of hypothermia on cultured mammalian (mouse) spinal cord neurons which had been subjected to a defined physical trauma (amputation of a primary dendrite 100μM from the perikaryon) were investigated.
3
Poon, Sze-wan, and 潘詩尹. "An evidence-based guideline on using cryotherapy for chemotherapy-induced oral mucositis in adult cancer patients." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48339192.
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Oral mucositis is a common adverse side-effect caused by cancer treatments and can lead to mucosa toxicity. Patients with oral mucositis may experience extreme pain and may not be able to eat, drink and talk and, as a result, their quality of life is impaired. Thirty to eighty five percent of patients undergoing chemotherapy would develop oral mucositis. Preventing or reducing incidence of oral mucositis and its severity can help reduce patients’ sufferings. One of the methods to achieve this objective is the oral cryotherapy, which is a prophylactic intervention. However, there is no evidence-based guideline to instruct nurses on providing oral cryotherapy to cancer patients.
The aims of this study are 1) to establish an evidence-based guideline on applying cryotherapy to reduce the incidence and severity of chemotherapy-induced oral mucositis, 2) to develop a standard nursing care and assess its transferability and feasibility, and 3) to develop a communication plan and evaluation plan for this guideline in an oncology ii-
department for the targeted local hospitals in Hong Kong.
A systematic search of four electronic journal databases identified seven articles corresponding to 6 randomized controlled trials (RCTs) on using oral cryotherapy for adult cancer patients. Five RCTs with high to weak quality reported supporting evidence for the beneficial effect of oral cryotherapy on chemotherapy-induced oral mucositis, whereas 1 RCT with moderate quality failed to identify supportive evidence for the use of oral cryotherapy. However, potential confounding factors were identified to be presented in that insignificant RCT. Hence, there was sufficient evidence to show that oral cryotherapy can significantly reduce chemotherapy-induced oral mucositis in adult cancer patients.
An evidence based guideline for using cryotherapy on chemotherapy-induced oral mucositis in adult cancer patients was established. The transferability and feasibility of the proposed oral cryotherapy guideline were assessed. As identified, the clinical situation and patient characteristics in the local settings are similar to those who reported in the reviewed studies. Staff readiness, skills and resources are also readily available in the target clinical settings. Findings from the reviewed studies of oral cryotherapy can be transferred to the local target settings and are feasible to be implemented. It is also estimated that the innovated guidelines for cryotherapy can save HK$3,210,745 per year for the target setting.
Stakeholders for the innovated guideline in the local setting were identified. And a communication plan was developed. A pilot study lasting for 10 weeks will be conducted to test the feasibility of the staff training session and the implementation of the oral cryotherapy guideline. Modification of innovated guidelines will be made after evaluating the data collected from the pilot study. Eventually, the final version of the evidence-based guideline will be established. A six months evaluation plan will be used to evaluate the implementation of the new guideline. The policy for adopting the oral cryotherapy will be determined with the outcome measures, including the incidence of chemotherapy-induced oral mucositis, mean of the oral mucositis score, staff satisfaction level, and the cost and benefit ratio of the innovated guideline.published_or_final_version
Nursing Studies
Master
Master of Nursing
4
Lui, Pui-ling, and 呂佩玲. "Evidence-based guidelines of using cryotherapy in reducing pain, knee swelling and improving range of motion for patients after total kneereplacement." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48335939.
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Introduction: Knee osteoarthritis is one of the common causes leading to musculoskeletal disability of the elderly around the world. Total knee replacement (TKR) is an effective and common treatment for end stage knee arthritis. Most papers suggest that early rehabilitation could improve postoperative knee function. However, postoperative pain and local swelling are the complications that diminish range of motion (ROM) and inhibit patients’ recovery. A comprehensive review of the literature reveals that cryotherapy is an effective and safe method to overcome these complications. In this paper, a guideline of using cryotherapy in reducing postoperative pain and knee swelling so as to improve the ROM of patients and promote recovery after TKR has been developed.
Objectives: The objectives of this translational research are: (1) to look for relevant papers that related to cryotherapy in reducing postoperative pain and knee swelling so as to improve the ROM of patients after TKR; (2) to gather and criticize the data obtained; (3) to develop a guideline of using cryotherapy in reducing pain, knee swelling and improving ROM of patients after TKR based on the evidence from the reviewed literature; (4) to assess the implementation potential of the newly developed guidelines; and (5) to establish the implementation and evaluation plans for the new innovation.
Methods: An empirical literature search published from 2001 to 2011 by several searching engines regarding cryotherapy in reducing postoperative pain and knee swelling with the aim to improve the ROM of patients after TKR has been conducted. After that, the qualities of relevant studies were retrieved and criticized by using the appraisal checklist of the SIGN (2004). The derived evidences were then be summarized and synthesized. An evidence-based guideline was established with reference to the evidence from the reviewed literatures and the results of the quality assessment. Recommendations are graded by SIGN (2004). The implementation potential including transferability, feasibility and cost-benefit ratio of the innovation were assessed as well. Lastly, implementation and evaluation plans have been developed to assess and appraise the effectiveness of the new guideline.
Results: Finally, seven studies were chosen as final references after methodological quality assessment. Four main types of comparison were made from these seven reviews including: (1) continuous compressive cryotherapy vs. compressive crepe bandage; (2) comparison in different temperature of cryotherapy; (3) outcome measures; and (4) complications in cryotherapy. After the summary, six main categories of recommendations were synthesized: (1) continuous compression cryotherapy; (2) effective temperature; (3) potential complications; (4) regular assessment; (5) duration; and (6) intermitted ice pack regimen. Based on these syntheses and recommendations, a guideline of using cryotherapy for patients after having TKR was developed.
Conclusion: With the implementation of the newly developed evidence-based cryotherapy guidelines for patients after having TKR in local clinical settings, the improvement in the ROM of the knee joint will be anticipated as a result of the reduction in postoperative pain and knee swelling.published_or_final_version
Nursing Studies
Master
Master of Nursing
5
Barry, Simon John. "An investigation into the effectiveness of cryotherapy following total knee replacement." Thesis, Coventry University, 2004. http://curve.coventry.ac.uk/open/items/ca73885a-2912-95ea-d424-c7a5e1c3c06a/1.
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Background: Cryotherapy is commonly used during physiotherapeutic rehabilitation of patients following total knee replacement (TKR). Evidence for treatment effectiveness within the current literature is contradictory and there are no clinical guidelines to inform cryotherapy treatment within this particular patient group. This study surveys current cryotherapy treatment efficacy in the acute post-operative management of TKR patients. Methods: In total 263 senior physiotherapists completed and returned a postal questionnaire, which, using open and closed questions investigated the use of cryotherapy following TKR. Survey results were used to inform a pragmatic randomized clinical trial (RCT) involving 133 consecutive TKR patients. The RCT investigated cryotherapy treatment efficacy in the acute post-operative management of TKR patients. Patients were randomized into three groups; no cryotherapy (NC), delayed cryotherapy (DC) and immediate cryotherapy (IC). The primary outcome measure was post-operative pain with knee swelling, active range of motion (AROM), function and levels of physiotherapy input assessed as secondary outcome measures. Observations were taken pre-operatively and at 3, 7 and 42 days post-operatively. Results: The survey reported that 33% of respondents used some form of cryotherapy routinely following TKR surgery. The two main methods of cryotherapy application were Cryocuff (59%) and crushed ice (30%). Treatments were most frequently applied between 24 hrs and 48 hrs post-surgery for 20 minutes, twice a day. Chi square analysis indicated significant differences (p<0.01) in between NHS and private sites relating to a lack of cryotherapy resources and treatment time for cryotherapy in the NHS. A lack of proven efficacy was the most cited reason for not applying cryotherapy treatment, and swelling the most common treatment indicator. There was particular uncertainty regarding the cleaning and sterilization of the Cryocuff device. The RCT indicated that patients in IC group had significantly less post-operative pain than the NC and DC groups at 3 days. Mean difference (p <0.05, 95% CI) in post-operative analogue scores (VAS, scale 0-10) was -1.6 (p <0.01, CI -2.49- to -0.707) for IC and NC; and -0.922 (p= 0.044, CI -0.183 to -0.009) for IC and DC groups. At 7 and 42 days there were significant reductions in VAS scores for both cryotherapy groups compared to the NC group. There was significant improvement in knee swelling, AROM, ability to transfer and need for additional physiotherapy in both cryotherapy treatment groups although no significant reduction in opiate requirement was found. Conclusions: In current clinical practice there was little consensus regarding treatment indicators, method of application and management of cryotherapy following TKR. However, in a RCT the use of cryotherapy combined with compression, as compared to a no cryotherapy control, led to significant reductions in patient reported pain, less post-operative swelling, greater recovery of AROM, faster return of function and less reliance on OPD physiotherapy treatment. It is concluded that cryotherapy combined with compression has an important role to play in the acute rehabilitation of TKR and should be considered as part of routine management.
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Lü, Fengjuan, and 吕凤娟. "Potential of bone marrow and umbilical cord derived mesenchymal stem cells in intervertebral disc repair." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48079753.
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Introduction: Intervertebral disc (IVD) degeneration is suggested to begin from the
nucleus pulposus (NP). Evidence from various studies highlights mesenchymal stem cells
(MSC), in most cases using bone marrow derived MSC, as a potential stem cell source
for NP regeneration. However MSC can be isolated from many sources with various
characteristics. There are indications that fetal or close to fetal tissue sources contain
MSC with relatively undifferentiated phenotype with respect to MSC from adult sources.
Moreover, umbilical cord (C)-MSC may have better chondrogenic differentiation potential
than bone marrow (B)-MSC. We hypothesize CMSC are different from BMSC, and more
efficient than BMSC in stimulating NP regeneration.
Methods: MSC were isolated from human bone marrow and umbilical cord with
corresponding ethical approval. BMSC and CMSC were characterized for cell surface
marker expression profile and differentiation potential.. RT-PCR of interest genes in NP
cells isolated from scoliosis and degenerate discs was performed to search for NP
degeneration indicators. Conditioned media (CM) was collected from confluent MSC
monolayer, and used for stimulation of four batches of degenerated NP cells isolated from
human degenerative intervertebral discs. Cell proliferation and cytotoxicity were assessed
by MTT assay. Proteoglycan content were measured by DMMB assay. Gene expression
of a series of degeneration related molecules including ACAN, SOX9, CDH2, CD55,
KRT19, KRT18, FBLN1 and MGP, and fibrosis related molecules, including MMP12,
HSP47, COL1A1, COL3A1 and FN1, of NP cells in MSC-CM were determined by real- time RT-PCR. All results were normalized to the control cells in basal medium. The
expression of discogenic, chondrogenic and osteogenic markers on BMSC and CMSC
were compared by RT-PCR.
Results and Conclusion: CMSC were similar to BMSC and fulfilled the minimum
criteria of MSC, however the expression of CD146, CD106 and Stro-1 was different, and
BMSC had a spontaneous osteogenesis tendency while CMSC expressed chondrogenic
marker even without TGF-beta stimulation. BMSC demonstrated a paracrine effect on
modulating human degenerated NP cells towards a non-degenerative phenotype in
stimulating cell proliferation, slightly enhancing proteoglycan production, upregulating
KRT19 while downregulating MMP12. Compared with BMSC, a higher paracrine effect of
CMSC was disclosed in modulating the phenotype of NP cells in all aspects tested, and
an intrinsic higher expression on CMSC of ‘potential NP markers’, including KRT19,
KRT18 and CD55, but lower expression of osteogenic markers, including RUNX2 and
ALPL, was revealed, which indicate a higher potential of CMSC for future clinical
application to treat IVD degeneration diseases. KRT19 and MMP12 were also confirmed
to be the highest differentially expressed candidate genes between cultured scoliosis and
degenerated human NP cells, indicating a high indicator potential of NP degeneration.
Furthermore, a subpopulation was detected in the degenerated NP cells that possessed
macrophage-like phenotype and activities, which may play a role in the pathogenesis of
IVD degeneration. In conclusion, studies in this thesis highlighted CMSC as a superior
source than BMSC for IVD repair. Further investigations into the active agents in the
conditioned media and the signalling pathway may help to elucidate the mechanism of
the effect.published_or_final_version
Orthopaedics and Traumatology
Doctoral
Doctor of Philosophy
7
Medina, Balbuena Sara [Verfasser], and Benito [Akademischer Betreuer] Yard. "The use of stem cells as a therapeutic modality for amelioration of chronic renal damage after warm or cold ischaemic insults / Sara Medina Balbuena ; Betreuer: Benito Yard." Heidelberg : Universitätsbibliothek Heidelberg, 2021. http://d-nb.info/1227585543/34.
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Medina, Balbuena Sara [Verfasser], and Benito A. [Akademischer Betreuer] Yard. "The use of stem cells as a therapeutic modality for amelioration of chronic renal damage after warm or cold ischaemic insults / Sara Medina Balbuena ; Betreuer: Benito Yard." Heidelberg : Universitätsbibliothek Heidelberg, 2021. http://nbn-resolving.de/urn:nbn:de:bsz:16-heidok-292709.
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Wong, Po-shan Susan, and 黃寶珊. "The Buddha Dhamma as a psychotherapeutic technique and how the Buddhist mindfulness practice could be integrated into thecontemporary social work service." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B48521784.
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This doctrinal study demonstrates in what way the ‘Universal Applicability’ of Buddha Dhamma can be reflected in the intervention process in view of the contemporary situation of the Buddhist Mindfulness being integrated as a psychotherapeutic technique. In past few decades, the Western psychotherapists recognize Mindfulness as ‘the heart of Buddhist meditation’ and apply it as an impartial psychotherapeutic technique to serve their clients’ physical health and psychological wellness. As recorded in the Buddhist Pāli tradition, through practicing Mindfulness meditation, people are able to comprehend the ‘Universal Applicability’ of Buddha Dhamma, to realize three universal characteristics (lakkhanas) of sentient existence, namely impermanence (anicca), un-satisfactoriness (dukkha), and non-self (anatta), and eventually to liberate their mind from suffering.
From studying the Buddhist teaching of Mindfulness embedded in the Satipaṭṭhāna Sutta and the Mahā-Satipaṭṭhāna Sutta, the researcher develops this tenet,
“the Buddhist Mindfulness could be an effective psychotherapeutic technique when it is practiced within the Buddhist context and supported by the theoretical foundation, and when the ‘Universal Applicability’ of the Buddha Dhamma is reflected in the therapeutic process ”.
Applying the tenet to study the case, the ‘Mindfulness-Based Stress Reduction Program’ (the MBSR) initiated by Dr. Jon Kabat-Zinn, she finds three issues which makes her hesitated to agree with the Western psychotherapists’ integrating the Buddhist Mindfulness as a stand-alone psychotherapeutic technique. The first two issues are the way the psychotherapists interpreting and implementing the Buddhist Mindfulness as a stand-alone technique without the Buddhist context and isolated from the Buddhist theoretical foundation. Resulted from the first two issues, the third one is the ‘Universal Applicability’ of Buddha Dhamma has no way to reflect in the treatment process to help people liberating from suffering.
After identifying these three issues, the researcher carries on to incorporate ideas of practicing Mindfulness suggested by the Pali Buddhist tradition, and collaborate with the Social Work Profession with applying transferrable skills of the ‘Experiential Learning’ techniques to design a pilot service—the Buddhist Mindfulness-Based Social Service Project (the BMBSS). The BMBSS, consists of (1) an Orientation Meeting, (2) the six-session Prerequisite Training (the PRT-BMBSS) and, (3) the twenty-six-session Buddhist Mindfulness-Based Social Service Program (the BMBSS), aims at demonstrating the way to support the ‘Practicing Facilitators’ and the ‘Practicing Novices’ to apply the Buddhist teaching of Mindfulness into their daily activities.
Moreover, the researcher designs the BMBSS Project in the way to promote interdisciplinary collaboration between Buddhist communities and the Social Work Profession to exchange ideas to benefit their services. The Social Work Profession may benefit from the Buddhist teaching on ‘non-self’ to apply its intrinsic technique of the ‘use of self’ to serve the clients, when the Buddhist communities may learn from the Social Work Profession to bring the Buddhist teaching to serve the society at large. Furthermore, ideas on supporting inter-disciplinary collaboration generated from developing the BMBSS may transfer into promoting dialogues and networking between the Buddhist communities and other professions to integrate the ‘Universal Applicability’ of Buddha Dhamma to serve the needs of the Buddhists and non-Buddhists.published_or_final_version
Buddhist Studies
Doctoral
Doctor of Philosophy
10
Van, Tubbergh Karen. "Skeletal muscle repair after micro-damage : effect of ice therapy on satellite cell activation." Thesis, Stellenbosch : University of Stellenbosch, 2005. http://hdl.handle.net/10019.1/16623.
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Thesis (MSc)--University of Stellenbosch, 2005.ENGLISH ABSTRACT: Cryotherapy is one of the popular treatments used to alleviate muscle soreness, especially in the competitive sports arena. However, the therapeutic use of cryotherapy is unsubstantiated because of a lack of proper investigations in the literature, especially a hypothesised effect on muscle recovery. Thus, our aims were to characterise satellite cell (SC) activity in human subjects with delayed onset muscle soreness (DOMS) and to shed light on the effect of cryotherapy on SC activity. DOMS was induced in six male subjects (24 ± 3 years) by completion of a downhill-run (DHR) protocol (5 x 8 min bouts, 2 min rest between bouts) at 70 or 80% of their individual peak treadmill speed. Ice application was applied to only one leg per subject for 3 days: 30 min every 2 hours, 5 times per day. In total 5 muscle biopsies were obtained from each subject: 1 baseline and 4 post-DHR. Post-DHR biopsies: 1 from each leg on day 1 and 7 (1st group, n=3) and 1 from each leg on day 2 and 9 (2nd group, n=3). DOMS was successfully induced as indicated by significant increases in muscle soreness at days 1 and 2 post-DHR (P < 0.01), and creatine kinase activity at day 1 post-DHR (P < 0.01). No difference in muscle soreness was found between treated and untreated legs. SC quiescence and activation were characterised by their expression of the cell surface markers CD34 and CD56 respectively. No significant change in quiescent SC was observed in the untreated or treated legs over time. However, at day 1 post-DHR the number of quiescent SC was significantly lower in the untreated compared with the treated leg (P < 0.05). There was a significant increase in activated SC numbers at day 2 post-DHR in the untreated leg, which was sustained up to day 9 post-DHR (P < 0.01). However, no such increase was found in biopsies taken on days 1 and 7. Also, no change was found in the treated leg, however a significant difference between the number of activated SC in untreated and treated legs on days 2 and 9 post-DHR (P < 0.01) was seen. No significant effect of DOMS or ice treatment was observed for the expression of the myogenic regulatory factors, MyoD and myogenin. C2C12 cell cultures induced to differentiate, however, did stain using these antibodies. This is the first study to report an effect of cryotherapy at the tissue level. In conclusion, this study highlights many unanswered questions on the SC response to DOMS at tissue level, and lays a good foundation for future studies.
AFRIKAANSE OPSOMMING: Kreoterapie is een van die gewilde behandelings wat gebruik word om spierseerheid te verlig, veral in die kompeterende sport arena, maar die gebruik van kreoterapie is onbevestig as gevolg van ‘n gebrek aan voldoende ondersoeke in die literatuur, veral ‘n hipotese oor die effek op spier-herstel. Ons doelstellings was dus om satellietsel (SC) aktiwiteit te ondersoek in mens proefpersone met vertraagde aanvang spierseerheid (DOMS) en ook om lig te werp op die effek van kreoterapie op SC aktiwiteit. DOMS was in ses mans proefpersone (24 ± 3 jare) geїnduseer deur voltooїng van ‘n afdraend-hardloop (DHR) protokol (5 x 8 min rondtes, 2 min rus tussen rondtes) teen 70 of 80% van elkeen se individuele maksimum trapmeul-spoed. Ys was vir 3 dae op net een been per proefpersoon aangewend: 30 min elke 2 ure, 5 keer per dag. 5 spierbiopsies in totaal was van elke proefpersoon verkry: 1 basislyn en 4 post-DHR. Post-DHR biopsies: 1 van elke been op dae 1 en 7 (1ste groep, n=3) en 1 van elke been op dae 2 en 9 (2de groep, n=3). DOMS was suksesvol geїnduseer soos aangedui deur die betekenisvolle verhogings in spierseerheid op dae 1 en 2 post-HR (P < 0.01) en kreatien kinase aktiwiteit op dag 1 post-DHR (P < 0.01). Geen verskil in spierseerheid is gevind tussen die onbehandelde en behandelde bene nie. SC dormansie en aktivering was gekarakteriseer deur die onderskeidelike uitdrukking van die sel oppervlak merkers CD34 en CD56. Geen betekenisvolle verandering is in SC dormansie in die onbehandelde en behandelde bene waargeneem nie, maar op dag 1 post-DHR was die getal dormante SC betekenisvol laer in die onbehandelde been as in die behandelde been (P < 0.05). Daar was ‘n betekenisvolle verhoging in die getalle geaktiveerde SC op dag 2 post-DHR in die onbehandelde been wat volgehou was tot op dag 9 post-DHR (P < 0.01), maar so ‘n verhoging was nie in biopsies wat op dae 1 en 7 geneem is gevind nie. Daar is ook geen verandering in die behandelde been gevind nie, maar ‘n betekenisvolle verskil in die getal geaktiveerde SC is tussen die onbehandelde en behandelde bene op dae 2 en 9 post-DHR gevind(P < 0.01). Geen betekenisvolle effek van DOMS en ys-aanwending vir die uitdrukking van die miogeniese (myogenic) regulatoriese faktore, MyoD en myogenin, is waargeneem nie. C2C12 sel kulture wat geїnduseer is om te differensieer het wel gekleur vir hierdie antiliggame. Dit is die eerste studie wat ‘n effek van kreoterapie op weefselvlak rapporteer. Ten slotte, hierdie studie beklemtoon baie onbeantwoorde vrae oor die SC respons op DOMS op weefselvlak en dit lê ‘n goeie grondslag neer vir toekomstige studies.
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Cardoso, Marcelo Gonçalves [UNESP]. "Estudo da eficiência da água ozonizada como solução irrigadora na eliminação de Candida albicans, Enterococcus faecalis e endotoxinas do canal radicular." Universidade Estadual Paulista (UNESP), 2006. http://hdl.handle.net/11449/100705.
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Primeiramente foi avaliada no estudo a ação antimicrobiana da água ozonizada frente suspensão composta por Candida albicans e Enterococcus faecalis, verificando o tempo necessário de ozonização da água para eliminação destes microrganismos. Nas próximas etapas, foi avaliada a eficiência da água ozonizada como agente irrigante, durante o preparo biomecânico, tanto na eliminação de Candida albicans e Enterococcus faecalis, assim como na neutralização de LPS de Escherichia coli inoculados no interior de canais radiculares. Foram utilizados 48 dentes humanos unirradiculados, sendo que nos canais radiculares de 24 espécimes, foram inoculados 20 mL de uma suspensão contendo C. albicans e E. faecalis, e nos outros 24 espécimes, foram inoculados 10 mL LPS de E. coli, verificando-se a ação da água ozonizada como agente irrigante durante o preparo biomecânico. Foram realizadas coletas das amostras (imediata e após sete dias da instrumentação), e os dados foram submetidos à análise estatística. Como resultados, pode-se observar que a ação antimicrobiana da água ozonizada por dez minutos foi efetiva frente à suspensão microbiana. Como agente irrigante durante o preparo biomecânico, a água ozonizada apresentou efetividade frente à suspensão de C. albicans e E. faecalis inoculada no interior dos canais radiculares na coleta imediata, porém, na segunda coleta apresentou pouco efeito residual. Na verificação da neutralização de endotoxina, a ação da água ozonizada como agente irrigante não apresentou efetividade na neutralização de LPS de E. coli inoculada nos canais radiculares, sendo que quantidades restantes de LPS apresentaram efeitos biológicos. Como conclusão, a água ozonizada foi eficiente na redução de C. albicans e E. faecalis inoculada no interior dos canais radiculares, mas não apresentou efeito sobre LPS de E. coli.
At first, the study was to evaluated the antimicrobial action of the ozonized water before the suspension composed of Candida albicans and Enterococcus faecalis, checking the necessary time of ozonization of the water in order to eliminate these microorganisms. In the next stages, the efficiency of ozonized water as an irrigant agent was evaluated, during the biomechanical preparation, as in the elimination of C. albicans and E. faecalis, as well as in the neutralization of Escherichia coli LPS inoculated into the root canals. Were used 48 single-rooted human teeth, seeing that in the root canals of 24 specimens, it were inoculated 20 mL of a suspension containing C. albicans and E. faecalis, and on the other 24 specimens, it were inoculated 10 mL of Escherichia coli LPS, having been checked the action of the ozonized water as an irrigant agent during the biomechanical preparation. Collections of samples (immediately and after seven days of the instrumentation) were carried out, and the data was submitted to statistical analysis. As a result, one could observe that the antimicrobial action of the ozonized water for ten minutes was effective before the microbial solution. As an irrigant agent during the biomechanical preparation, the ozonized water presented effectiveness before the suspension of C. albicans and E. faecalis inoculated into the root canals in the immediate collection, however, in the second collection it presented little residual effect. When verifying the endotoxin neutralization, the action of the ozonized water as an irrigant agent did not present effectiveness in the neutralization of E. coli LPS inoculated in the root canals, seeing that the remaining quantities of LPS presented biological effects. It was concluded that, the ozonized water was efficient in the reduction of C. albicans and E. faecalis inoculated inside the root canals, but it did not present any effect over E. coli LPS.
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Pinzon-Arango, Paola A. "Investigating the effects of cranberry juice on the physicochemical properties of Escherichia coli for the prevention of urinary tract infections." Worcester, Mass. : Worcester Polytechnic Institute, 2008. http://www.wpi.edu/Pubs/ETD/Available/etd-010908-121947/.
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Cardoso, Marcelo Gonçalves. "Estudo da eficiência da água ozonizada como solução irrigadora na eliminação de Candida albicans, Enterococcus faecalis e endotoxinas do canal radicular /." São José dos Campos : [s.n.], 2006. http://hdl.handle.net/11449/100705.
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Orientador: Antonio Olavo Cardoso JorgeBanca: Sandra Marcia Habitante
Banca: Mariella Vieira Pereira Leão
Banca: Juliana Campos Junqueira
Banca: Claudio Antonio Talge Carvalho
Resumo: Primeiramente foi avaliada no estudo a ação antimicrobiana da água ozonizada frente suspensão composta por Candida albicans e Enterococcus faecalis, verificando o tempo necessário de ozonização da água para eliminação destes microrganismos. Nas próximas etapas, foi avaliada a eficiência da água ozonizada como agente irrigante, durante o preparo biomecânico, tanto na eliminação de Candida albicans e Enterococcus faecalis, assim como na neutralização de LPS de Escherichia coli inoculados no interior de canais radiculares. Foram utilizados 48 dentes humanos unirradiculados, sendo que nos canais radiculares de 24 espécimes, foram inoculados 20 mL de uma suspensão contendo C. albicans e E. faecalis, e nos outros 24 espécimes, foram inoculados 10 mL LPS de E. coli, verificando-se a ação da água ozonizada como agente irrigante durante o preparo biomecânico. Foram realizadas coletas das amostras (imediata e após sete dias da instrumentação), e os dados foram submetidos à análise estatística. Como resultados, pode-se observar que a ação antimicrobiana da água ozonizada por dez minutos foi efetiva frente à suspensão microbiana. Como agente irrigante durante o preparo biomecânico, a água ozonizada apresentou efetividade frente à suspensão de C. albicans e E. faecalis inoculada no interior dos canais radiculares na coleta imediata, porém, na segunda coleta apresentou pouco efeito residual. Na verificação da neutralização de endotoxina, a ação da água ozonizada como agente irrigante não apresentou efetividade na neutralização de LPS de E. coli inoculada nos canais radiculares, sendo que quantidades restantes de LPS apresentaram efeitos biológicos. Como conclusão, a água ozonizada foi eficiente na redução de C. albicans e E. faecalis inoculada no interior dos canais radiculares, mas não apresentou efeito sobre LPS de E. coli.
Abstract: At first, the study was to evaluated the antimicrobial action of the ozonized water before the suspension composed of Candida albicans and Enterococcus faecalis, checking the necessary time of ozonization of the water in order to eliminate these microorganisms. In the next stages, the efficiency of ozonized water as an irrigant agent was evaluated, during the biomechanical preparation, as in the elimination of C. albicans and E. faecalis, as well as in the neutralization of Escherichia coli LPS inoculated into the root canals. Were used 48 single-rooted human teeth, seeing that in the root canals of 24 specimens, it were inoculated 20 mL of a suspension containing C. albicans and E. faecalis, and on the other 24 specimens, it were inoculated 10 mL of Escherichia coli LPS, having been checked the action of the ozonized water as an irrigant agent during the biomechanical preparation. Collections of samples (immediately and after seven days of the instrumentation) were carried out, and the data was submitted to statistical analysis. As a result, one could observe that the antimicrobial action of the ozonized water for ten minutes was effective before the microbial solution. As an irrigant agent during the biomechanical preparation, the ozonized water presented effectiveness before the suspension of C. albicans and E. faecalis inoculated into the root canals in the immediate collection, however, in the second collection it presented little residual effect. When verifying the endotoxin neutralization, the action of the ozonized water as an irrigant agent did not present effectiveness in the neutralization of E. coli LPS inoculated in the root canals, seeing that the remaining quantities of LPS presented biological effects. It was concluded that, the ozonized water was efficient in the reduction of C. albicans and E. faecalis inoculated inside the root canals, but it did not present any effect over E. coli LPS.
Doutor
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Fernandes, Carolaine Bitencourt Ferreira. "Uso terapêutico de vacinas contra HPV em mulheres com lesão de colo de útero." Universidade Federal de Juiz de Fora (UFJF), 2013. https://repositorio.ufjf.br/jspui/handle/ufjf/5562.
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O câncer de colo do útero é o segundo tumor mais frequente na população feminina e a segunda causa de morte por neoplasia entre mulheres. A infecção persistente pelo vírus HPV é condição necessária para o aparecimento da doença, bem como de suas lesões precursoras. O uso da vacinação profilática contra o HPV tem se mostrado efetivo na prevenção da doença e, devido ao mecanismo de desenvolvimento do câncer a partir da infecção viral, novas partículas vacinais vêm sendo desenvolvidas com o objetivo de uso terapêutico, ou seja, na vigência de lesões. Este trabalho teve como objetivo realizar uma revisão sistemática da literatura sobre o uso de vacinas terapêuticas contra o HPV e sobre as novas partículas utilizadas com este fim. Foi feita uma consulta às bases de dados MEDLINE, PUBMED e LILACS, às coleções SciELO e à BIBLIOTECA COCHRANE, utilizando-se as palavras-chave “papillomavirus humano”, “”HPV”, “vacina”, “vacinação”, “terapêutico” e “imunoterapia” em diferentes combinações, sem limite de data. Dos 713 artigos encontrados inicialmente, 352 foram excluídos por estarem repetidos nas diferentes bases de dados, 217 por serem artigos de revisão, 86 por serem realizados em animais, 24 publicados em idiomas que não o inglês, português e espanhol, 15 de outras localizações anatômicas que não o colo do útero, 2 em pacientes HIV positivos, 1 em homens, 2 cujas pacientes possuíam apenas infecção pelo vírus, mas não lesão no colo e 1 realizado in vitro. Um último artigo foi excluído pois utilizava a vacina após a retirada da lesão do colo das pacientes. Desta forma foram selecionados 12 artigos para esta revisão sistemática. Estes são artigos de fase I e II, realizados com poucas pacientes e apenas 2 deles são randomizados e cegados. Não se pôde atribuir nenhuma medida estatística aos resultados, visto a heterogeneidade das publicações. Os estudos analisados utilizaram partículas vacinais baseadas nas proteínas E6, E7 e E2 do HPV, concluindo que a proteína E7 é a mais promissora para uso nas vacinas terapêuticas. Esta revisão concluiu que o uso das vacinas baseadas na proteína E7 de HPV é potencialmente benéfico no tratamento das lesões de colo uterino, sendo um campo de estudo promissor, mas esta conclusão deve ser analisada com cautela devido à ausência de estudos realizados com maior número de pacientes e com critérios metodológicos mais rígidos.
Cancer of the cervix is the second most common tumor in the female population and the second cause of death from cancer among women. Persistent infection by HPV is a necessary condition for the onset of the disease and its precursor lesions. The use of prophylactic vaccination against HPV has been shown to be effective in preventing disease and mechanism of cancer development from the viral infection, new particle vaccine have been developed with the aim of therapeutic use, in other words, in the presence of injuries. This study aimed to perform a systematic review of the literature on the use of therapeutic vaccines against HPV and the new particles used for this purpose. Was made a query to the databases MEDLINE, PUBMED and LILACS, SciELO and the collections COCHRANE LIBRARY, using the key words "human papillomavirus", "" HPV "," vaccine "," vaccination "," therapeutic " and "immunotherapy" in different combinations, without a time limit. Of the 713 articles found initially, 352 were excluded because they were repeated in different databases, 217 to be review articles, 86 were conducted in animals, 24 published in other languages than English, Portuguese and Spanish, 15 other anatomical locations than the cervix, 2 in HIV-positive patients, 1 in men, 2 whose patients had only infection, but not injury lap and 1 conducted in vitro. One last item was deleted because the vaccine used after removal of the lesion of the cervix patients. Thus 12 articles were selected for this systematic review. These articles are phase I and II, realized with few patients and only two of them are randomized and blinded. We were unable to assign any statistical measure the results, since the heterogeneity of publications. The analyzed studies used particle vaccine based on proteins E6 and E7 of HPV E2, concluding that the E7 protein is the most promising for use in therapeutic vaccines. This review concluded that the use of vaccines based on HPV E7 protein is potentially beneficial in the treatment of lesions of the cervix, being a promising field of study, but this finding should be considered with caution due to the lack of studies with larger numbers of patients and strict methodological criteria.
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Krige, Marilyn. "Molecular investigation of the chlorine and antibiotic resistance mechanisms of Escherichia coli isolated from natural water sources in the Western Cape." Thesis, Stellenbosch : University of Stellenbosch, 2009. http://hdl.handle.net/10019.1/2779.
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Thesis (MScMedSc (Pathology. Medical Microbiology))--University of Stellenbosch, 2009.Water is used for various purposes and contamination can have severe implications if untreated. One of the most common and cost effective water disinfectants, especially used in developing countries, is chlorine. However, microorganisms have developed different mechanisms in response to environmental stress conditions, such as the viable but nonculturable (VBNC) effects possibly displayed in this study, enabling them to survive. Chlorine may also exert several effects on microorganisms, such as the expression of multi-substrate efflux pumps, decreased membrane permeability and transport inhibition that may lead to chlorine tolerance and antimicrobial resistance. In a descriptive and comparative study, the molecular characteristics of E. coli strains isolated from environmental waters in the Western Cape and the possible relationship between chlorination and antimicrobial resistance were investigated. Water and biofilm samples were exposed to chlorine, as well as efflux pump inhibitor (EPI) concentrations, and surviving E. coli strains were tested for their phenotypic characteristics including antimicrobial susceptibility profiles and morphological types. Candidate genes possibly involved in resistance to antimicrobials, disinfection and efflux pumps were detected with polymerase chain reaction (PCR) and sequenced. Sequencing analysis and homology searches were done and E. coli strains were typed as either Enteropathogenic E. coli strains (EPEC) or Enterotoxigenic E. coli strains (ETEC) on the presence of virulence genes. All water and biofilm sources examined were heavily polluted with E. coli, and a high enumeration level of this indicator organism of faecal contamination was recorded. Chlorine tolerance was found to be associated with antimicrobial resistance. Addition of EPI with exposure to chlorine decreased enumeration levels of these organisms, suggesting that efflux pumps may play a role in tolerance to chlorine. Several morphological patterns were described amongst the E. coli strains and a change in this was recorded after exposure to chlorine. Highly resistant antibiograms displayed by the isolated strains included ampC β-lactamase producing E. coli strains and extended spectrum β-lactamases (ESBLs). Amplification of the candidate genes selected for heatshock, oxidative stress genes and efflux pump were most frequently detected while the structural genes involved in fluoroquinolones (FQs) resistance were detected less frequently in the selected strains. Sequencing of these amplified candidate genes demonstrated various changes in amino acid sequences, including one common mutational pathway taken by E. coli when exposed to stress conditions. Further homology searches of the sequenced candidate genes illustrated similarities in 19 pathogenic and 14 non-pathogenic E. coli as well as 3 Shigella strains. Detection of virulence genes found three EPEC strains (bfpA, eaeA), two EPEC (eaeA), ten EPEC (bfpA) and one ETEC strain (st) amongst the isolates. This study underlines the need for monitoring our water sources, which poses a public health risk due to incomplete chlorination, antimicrobial resistance and the spread of clinically relevant pathogenic strains.
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Boxhammer, Veronika. "Developmant of a safe therapeutic window for cold atmospheric plasma treatments." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-177756.
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Ramez-Baydoun, Lubna Lulu. "Novel chelating agents for therapeutic use." Thesis, King's College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406043.
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Betz, Jennifer. "The Use of Improvisation in Therapeutic Practices." Kent State University Honors College / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1557312650223249.
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Xiang, Hong. "Effects of myo-inositol and, or triiodothyronine (T₃) treatment on cardiac dysfunction and elevated myocardial lipid levels in STZ-diabetic rats." Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/26675.
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A number of experimental studies have implied a link between diabetes-induced lipid accumulation in the myocardium and the development of cardiomyopathy. Since diabetics excrete large amounts of myo-inositol which is a lipotropic agent, this study was undertaken to investigate the effects of myo-inositol on the elevated myocardial lipid levels and the depressed cardiac performance of diabetic rats. Diabetes was induced in female Wistar rats (190-215 g) with streptozotocin (STZ) (55 mg/kg, i.v.). Three days after diabetes induction, myo-inositol was administered in the drinking water (2.5 g/kg/day) for a 8 week period. Untreated diabetics exhibited a loss of body weight, hyperglycemia, hypoinsulinemia and hypothyroidism. These effects were not altered after myo-inositol treatment. STZ-diabetes also produced a significant elevation of plasma and myocardial triacylglycerol, cholesterol and phospholipid. Myo-inositol treatment decreased these lipid levels. In addition, hearts from diabetic animals had a decreased ability to develop left ventricular developed pressure (LVDP) and both the rate of pressure rise (+dP/dt) and the rate of pressure decline (-dP/dt) were also reduced. Hearts from myo-inositol-treated diabetic animals showed a partial but definite improvement of cardiac function.
As diabetes-induced hypothyroidism was not altered after myo-inositol supplementation, a combination treatment of both myo-inositol (2.5 g/kg/day, p.o. daily) and T₃ (30 ug/kg/day, s.c. daily) was then undertaken to determine whether heart function of diabetic rats could be further improved. STZ-diabetic rats were characterized by a loss of body weight, hyperglycemia and hypoinsulinemia; none of which were altered by either T₃ or myo-inositol plusT₃ treatment. T₃ treatment normalized the thyroid state of diabetic animals as shown by Tahiliani and McNeill (1984). However, plasma and myocardial triacylglycerol, cholesterol and phospholipid levels of diabetic rats either remained elevated or were further increased with T₃ or myo-inositol plus T₃ treatment. In addition, T₃ treatment alone did not prevent cardiac dysfunction in diabetic rats. There was, however, some improvement in heart function in the groups treated with both myo-inositol and T₃, but the improvement was not as pronounced as with myo-inositol treatment alone.Pharmaceutical Sciences, Faculty of
Graduate
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Alder, Louise B. A. "Immunoregulatory properties of polyclonal immunoglobulin for therapeutic use." Thesis, University of Newcastle Upon Tyne, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361937.
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Lloyd, Jonathan. "The therapeutic use of metaphor : a heuristic study." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/the-therapeutic-use-of-metaphor-a-heuristic-study(a020949f-3653-4812-af1d-ccbf49e53f98).html.
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Background: This research was designed to explore the experience and understanding of counsellors' and psychotherapists' engagement with metaphors in the therapeutic process. The aim is to reflect on the experience of therapists involved in therapeutic metaphors from differing perspectives. Methodology: In a heuristic study a group of seven therapists (counsellors and psychotherapists) shared their use of metaphors in their therapy practice. Data were collected through an informal conversational interview that supported the participants to share their experiences in a natural dialogue. Findings: The experience of using metaphor in therapy appears to involve a multi-faceted web of generation, construction and development between the therapist and client. Various levels of depth of metaphor in therapy were identified along with links to transferential and cultural issues. Metaphors of hope also appear to be potentially important. Discussion: The findings suggest that the use of metaphors in therapy is pervasive. Metaphors that reflect an empathic connection and encounter between therapist and client were identified. Dualistic thinking around the origination of metaphors in therapy is challenged and the concept of co-creation and the mutual development of moving metaphors is discussed. Environmental and cultural influences are considered alongside transferential aspects. Conclusion: It appears that the use of metaphor in therapy is pervasive and offers an opportunity for therapeutic change. The consideration of the construction of metaphors and their mutual development may be useful for therapists to consider. This research highlights the need for more investigation with regard to client perspectives, the environmental impacts on metaphors in therapy and who the therapist and client stand for metaphorically for each other.
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Ngwa, Conelius. "Use of peptide nucleic acids as therapeutic agents." Thesis, Aston University, 2014. http://publications.aston.ac.uk/24385/.
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Marnewick, Jeanine Lucasta. "Cancer modulating properties of unique South African herbal teas (rooibos and honeybush) in short term in vitro and in vivo carcinogenesis assays." Thesis, Stellenbosch : Stellenbosch University, 2004. http://hdl.handle.net/10019.1/21888.
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Dissertation (PhD)--University of Stellenbosch, 2004.ENGLISH ABSTRACT: This thesis provides the first scientific evidence on the cancer modulating properties of two unique South African herbal teas, rooibos (Aspalathus Iinearis) and honeybush (Cyclopia intermedia) utilizing in vitro as well as in vivo carcinogenesis assays by: • Demonstrating the in vitro antimutagenic activity of aqueous extracts of the herbal teas against the metabolic activated mutagens, 2-acetylaminofluorene (2- AAF) and the mycotoxin, aflatoxin B1 (AFB,) as well as, to a certain extent, against the direct acting mutagen, hydrogen peroxide, utilizing the Salmonella typhimurium mutagenicity assay. • Increasing the activity of hepatic drug metabolizing enzymes, glutathione Stransferase alpha and UPD-glucuronosyl transferase, and reduced the oxidative stress by stabilizing the level of reduced glutathione (GSH) resulting in an increased hepatic reduced to oxidized glutathione ratio (GSG:GSSG). No toxic effects were noticed in rats consuming the herbal teas for 10 weeks as their sole source of drinking fluid. • Demonstrating the ex vivo modulation of 2-AAF- and AFB1-induced mutagenesis by sub- cellular hepatic fractions of rats consuming the herbal teas in the Salmonella mutagenicity assay. Hepatic cytosolic fractions protected against mutagenesis of both mutagens, while the microsomal fractions exhibited a reduced capacity to metabolize AFB1 to its active mutagenic metabolite. • Providing evidence for the in vivo modulation of tumour promotion using the liver as well as the two-stage skin carcinogenesis animal models. The unprocessed herbal teas arrested proliferation of the placental form of glutathione-Stransferase (GSTP+) altered cells as well as reduced the total number of enzyme altered foci in the liver of rats. Topical application of polyphenolic fractions of the various herbal teas prior to 12-0-tetra-decanoylphorbol-13-acetate (TPA) tumour promotion, reduced tumour formation in mouse skin initiated with 7,12-dimethylbenz[ ajanthracene (DMBA). The protective effect was illustrated by a decreased tumour incidence, a reduction in tumour volume as well as a delayed onset of tumour development. The f1avanol/proanthocyanidin content of the fractions could playa major role in the protection against skin tumour promotion. • Proposing possible mechanisms whereby rooibos and honeybush herbal teas could exert their cancer modulating properties with respect to in vitro and ex vivo antimutagenicity, in vivo oxidative status and reduced tumour promotion. • Providing evidence that the herbal teas mimic the cancer modulating properties of green and black teas although differences exist, presumably due to differences in the polyphenolic constituents. • Suggesting that rooibos and honeybush herbal teas may play an important role as chemopreventive agents in the modulation of cancer.
AFRIKAANSE OPSOMMING: Hierdie tesis bevat die eerste ondersoek na die effek van waterige en polifenoliese ekstrakte van rooibos (Aspalathus Iinearis) en heuningbos (Cyclopia intermedia) op verskeie aspekte van kankerontwikkeling. Die twee kruietees is uniek aan Suid-Afrika en kan 'n belangrike rol speel in die voorkoming van kanker. Verskillende in vitro so wei as in vivo studies het die volgende getoon: • Antimutageniese aktiwiteite teen die metabolies-geaktiveerde mutagene, 2- asetielaminofluoreen (2-AAF) en die mikotoksien, aflatoksien B1 (AFB1) in die Salmonella fyphimurium mutagenisiteitstoets. 'n Beperkte mate van beskerming is ook verleen teen die oksidatiewe mutageen, waterstofperoksied, sonder metaboliese aktivering. • Verhoogde aktiwiteite van die fase II ensieme, glutatioon S-tranferase alfa en UDP-glukuronidase, wat liggaamsvreemde verbindings metaboliseer. Die kruietees verlaag die oksidasietoestand soos weerspieel word deur 'n toename van gereduseerde glutatioon tot die geoksideerde vorm in die lewer van rotte wat 10 weke hierdie kruietees gedrink he!. Die kruietees het geen toksiese uitwerking op die rotte gehad nie. • Antimutageniese aktiwiteite van subselluiE~re fraksies van die lewer teenoor 2- AAF en AFB1 in die Salmonella toets. Die sitosolfraksie van die rotlewer bied beskerming teen die ge"induseerde mutagenese van beide mutagene, terwyl die mikrosomale fraksie ook die metaboliese aktivering van AFB1 na die aktiewe mutageniese metaboliet verminder. • In vivo modulering van kankerpromosie met behulp van bekende rotlewer en muisvel kankerontwikkelingsmodelle. In die lewermodel het die ongeprosesseerde kruietees beide die ontwikkeling en getal van GSTP+ fokusse onderskeidelik vertraag en verminder. In die geval van die velkankermodel het aanwending van polifenoliese fraksies van die kruietees beskerming gebied teen die ontwikkeling van velkankers by muise. Die aantal en grootte van die tumors het afgeneem terwyl die verskyning daarvan ook vertraag is. • Verskeie meganismes waardeur rooibos- en heuningboslee moonllik kanker kan moduleer word voorgeslel. Verskille in die polifenoliese sameslelling asook hul onderskeie konsenlrasies kan 'n belangrike rol speel in die kankerveranderende effekle van die lees. • Oal gereelde inname van rooibos- en/of heuningboslee moonllik 'n belangrike rol kan speel in die voorkoming van dieel- en omgewings-geYnduseerde kankers.
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Cheng, Ka-wing, and 鄭家榮. "Preventive potential and mechanism of dietary phenolics on the formation of mutagenic heterocyclic amines." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B4284177X.
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The Best PhD Thesis in the Faculties of Dentistry, Engineering, Medicine and Science (University of Hong Kong), Li Ka Shing Prize,2008-2009published_or_final_version
Biological Sciences
Doctoral
Doctor of Philosophy
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AL-Mangour, Bandar. "The use of cold sprayed alloys for metallic stents." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=107900.
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With the invention of the coronary stent, which is a wire metal mesh tube designed to keep the arteries open in the treatment of heart diseases, promising clinical outcomes were generated. However, the long term successes of stents have been delayed by significant in-stent restenosis (blockages) and stent fracture. In this research work, it has been proposed to use Cold Gas Dynamic Spraying (CGDS) coating material as an alternative choice to manufacture metallic stent. In CGDS, fine particles are accelerated to a high velocity and undergo solid-state plastic deformation upon impact on the substrate, which leads to particle-particle bonding. The feature of CGDS distinct from other thermal spray techniques is that the processing gas temperature is below the melting point of the feedstock. Therefore, unwanted effects of high temperatures, such as oxidation, grain growth and thermal stresses, are absent. In response to the fact that the majority of stents are made from stainless steel (316L) or Co-Cr alloy (L605), this study specifically addresses the development and characterization of 316L and 316L mixed with L605 coatings produced by the CGDS process. Scanning electron microscopy and electron backscatter diffraction were used to investigate the microstructural changes of these coatings before and after annealing. The effect of gas type on the microstructure of 316L coatings and the role of post-heat treatment in the microstructure and properties are also studied. Of particular interest are grain refinement, heat treatment, mechanical properties and corrosion behavior of the cold sprayed material.L'invention du stent coronaire, est un tube en treillis métallique conçu pour maintenir les artères ouvertes dans le traitement des maladies cardiovasculaires. Des résultats cliniques prometteurs ont été rapportés. Cependant, le succès à long terme des stents est problématique à cause des resténoses intra-stent et des fractures de stent par fatigue. Dans ce travail de recherche, il est proposé d'utiliser la technologie de pulvérisation dynamique des gaz à froid (CGDS) comme une alternative pour la fabrication de stents métalliques. En CGDS, de fines particules sont accélérées avec une vitesse élevée et subissent une déformation plastique à l'impact sur un substrat. La particularité du CGDS parmi les autres techniques de pulvérisation thermique est que la température des gaz dans le processus est bien en dessous du point de fusion de la matière. Par conséquent, les effets indésirables des températures élevées, telles que l'oxydation, la croissance du grain et les contraintes thermiques, sont absents. Comme la majorité des stents sont faits en acier inoxydable 316L et en alliage Co-Cr, cette étude porte spécifiquement sur le développement et la caractérisation de l'acier inoxydable et l'acier inoxydable 316L mélangé avec revêtements d'alliages Co-Cr produite par le procédé CGDS. Les techniques de microscopie électronique à balayage et à diffraction d'électrons rétrodiffusés ont été utilisées pour étudier les changements de microstructures de ces revêtements avant et après recuit. L'effet du type de gaz sur la microstructure des revêtements 316L et le rôle du post-traitement thermique à froid par pulvérisation dans la microstructure et les propriétés mécaniques et électrochimiques ont été également étudiées.
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Stapleton, Graham Neil. "A study of the effects of sucralfate in the bile duct litigated pig peptic ulcer model with particular reference to the effects on the physico-chemical properties of gastric mucus and including comparisons with famotidine and misoprostol." Master's thesis, University of Cape Town, 1992. http://hdl.handle.net/11427/25727.
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Sucralfate is a drug that effectively heals duodenal, gastric and oesophageal ulcers. It is not absorbed systemically and it has been shown to act locally by coating the ulcer base. However when it was also shown to prevent stress ulcers and ethanolinduced gastric mucosa! lesions, it seemed likely that it acted in some way to improve the effectiveness of the gastric mucosa! barrier. Some investigators suggested that it did so by stimulating local prostaglandin release. The Slomiany group, on the basis of in vitro work on the effects of Sucralfate on pig gastric mucus, claimed that Sucralfate acted by altering the physico-chemical properties of mucus to increase the viscosity and retard the back diffusion of H+ ions. The work described in this dissertation set out to verify, in vivo, these claimed effects on mucus, using an experimental porcine model of peptic ulceration, the bile duct ligated pig. In addition, the effects of Sucralfate were compared with those of Famotidine and Misoprostol, and changes in mucous prostaglandins, gastric juice pepsin and gastric flora were sought. By way of introduction, the known and postulated actions of Sucralfate, current understanding of gastric mucus physiology and pathogenesis of peptic ulceration, have been reviewed, as have experimental animal models of peptic ulceration, in order to justify using the bile duct ligated pig model.
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Thomas, Becky L. "The Use of Therapeutic Rituals in Substance Abuse Treatment." DigitalCommons@USU, 2001. http://digitalcommons.usu.edu/etd/2712.
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This study explored the use of rituals in substance abuse counseling. Data were obtained from a total of 25 mental health workers in the substance abuse field from the northern region of Utah. Four research questions were asked about rituals and their use in substance abuse counseling: (I) Are addictions therapists using rituals? (2) How did therapists determine when to use rituals? (3) What types of rituals do they use? and (4) How do therapists assess ritual effectiveness? Results indicated that about three fourths of the mental health workers questioned were using rituals in their treatment protocol with substance abuse clients. The most common methods used for determining when to implement rituals into treatment were (a) clients were emotionally stuck, (b) client's cognitive ability, and (c) therapist's perception. The findings also suggested that therapists presented means of assessing the effectiveness of the rituals they implemented, but the data also supported past literature findings that showed little empirical means of assessment.
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Hakala, John C. "The therapeutic use and effectiveness of humor in psychotherapy." Online version, 1998. http://www.uwstout.edu/lib/thesis/1998/1998hakalaj.pdf.
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Kjellin, Jessica, and Sara Norman. "Arbetsterapeutstudenters utvecklande av ”therapeutic use of self” - En litteraturstudie." Thesis, Örebro universitet, Institutionen för hälsovetenskaper, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-84409.
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Treece, Christine A. "Psychologists' Use of Dogs in Psychotherapy: A Therapeutic Exploration." Antioch University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=antioch1554402231989459.
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Parsons, Ann Bernardene. "Designing a resource guide for horticultural therapy programs at botanical gardens and arboreta." Thesis, Virginia Polytechnic Institute and State University, 1985. http://hdl.handle.net/10919/104531.
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余詩德 and Sze-tak Yu. "Effects of Chinese green tea and tea catechins on lipolysis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31969677.
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Zhang, Jingjing, and 张晶晶. "The anti-cancer properties of cyclometalated gold(III) complexes and organogold(III) supramolecular polymers." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/208171.
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Prompted by the successful clinical application of cisplatin in cancer therapy, worldwide efforts have been devoted to develop new metal-based drugs for anticancer treatment. Gold(III) complexes at first received attention as anti-cancer drug candidates because of their square-planar geometry which resembles that of platinum(II) complexes. Subsequent studies revealed that various gold(III) complexes displayed promising anti-cancer activities with different biological mechanisms. Although some achievements have been obtained in the development of anti-cancer gold(III) complexes, challenges including the improvement of bioavailability, stability and selectivity, elucidation of the action mechanisms, and the development of novel delivery approaches of gold(III) complexes to reduce systematic toxicity, remain to be exploited.
A panel of anti-cancer complexes [AuIII(R-C^N)(L)]n+ (wherein HC^N is 2-phenylpyridine, L is biguanide or biuret) have been identified and described in Chapter 3. Biguanide or biuret have been employed to improve the solubility of the complexes in aqueous solutions. Meanwhile, the lipophilicity could readily be adjusted by varying the R group to obtain a balance between lipophilicity and aqueous solubility. Among the synthesized complexes, the cationic complexes, [AuIII(butyl-C^N)biguanide]Cl (3.1) and [AuIII(C^N)biguanide]Cl (3.2) are soluble in aqueous solutions with solubility over 5 mg/mL. Besides, introduction of butyl groups to 3.1 and [AuIII(butyl-C^N)biuret] (3.3) resulted in higher cellular uptake of gold, which might enhance their cytotoxic activities (IC50 values: 1.5–17 μM) compared with 3.2 and [AuIII(C^N)biuret] (3.4) (IC50 values: 9.4–47.3 μM). Moreover, 3.1 was also found to induce cell cycle arrest in S-phase and endoplasmic reticulum (ER) damage in human cervical epithelial carcinoma (HeLa) cells, and display significant anti-angiogenic activity at its sub-cytotoxic concentrations.
In Chapter 4, a series of gold(III) complexes with dithiocarbamate and 2-phenylpyridine ligands to target deubiquitinases (DUBs), have been designed. These complexes achieved significant inhibition on purified DUBs. Notably, [AuIII(2-(4-nbutylphenyl) pyridyl)(diethyldithiocarbamate)]PF6 (4.1) inhibited both the purified (IC50 values: 46–223 nM) and cell-based DUBs activities with high efficiency. Its interaction with DUB UCHL1 and peptides which are present in several types of DUBs and contain active cysteine residue were confirmed by mass spectrometric analysis. All complexes displayed significant cytotoxicities, and those containing diethyldithiocarbamate ligand displayed specific cytotoxicity on breast cancer cells. Accumulation of a tumor suppressor p53, cell-cycle arrest, and apoptotic cell death were induced in breast cancer cells by 4.1. Besides, 4.1 also showed anti-angiogenic effects. These biological activities might be related with DUBs inhibition.
In Chapter 5, a cytotoxic complex [AuIII(C^N^C)(4-dpt)](CF3SO3) (5.1, HC^N^CH = 2,6-diphenylpyridine; 4-dpt = 2,4-diamino-6-(4-pyridyl)-1,3,5-triazine) has been designed to self-assemble into supramolecular polymers (5.1-SP) in acetonitrile. In physiologically relevant solutions, 5.1-SP displayed a sustained-release property of the anti-angiogenic ligand 4-dpt, and in the presence of glutathione (GSH), [AuIII(C^N^C)-GSH] adduct(s) were also gradually released. The supramolecular polymers 5.1-SP also showed selective cytotoxicity toward cancerous cells, and could act as drug-carriers of other cytotoxic agents to achieve sustained-release behavior.published_or_final_version
Chemistry
Doctoral
Doctor of Philosophy
34
Kilinkissa, Ornella Edlyne Youdaga. "Physical chemical properties of selected pharmaceutical co-crystals." Thesis, Cape Peninsula University of Technology, 2014. http://hdl.handle.net/20.500.11838/731.
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Thesis submitted in fulfilment of the requirements for the degree
Magister Technologiae: Chemistry
in the Faculty of Applied Sciences at the
CAPE PENINSULA UNIVERSITY OF TECHNOLOGY
2014The solid state modification of a given active pharmaceutical ingredient is a desired way to alter its physicochemical properties, such as solubility or bioavailability. The solubilitymelting point relationship of the ensuing co-crystal or salt is not fully understood. In this thesis, a series of model co-crystals and pharmaceutical co-crystals and salts of baclofen were investigated. The model co-crystals were prepared from 4,4’-bipyridine (BIPY) and 1,2-bis(4-pyridyl)ethane (ETBIPY) used as host compounds which were combined with a series of carboxylic acids as co-formers, such as p-toluic acid (PTA), rac-phenylbutyric acid (racPBA), racemic and S-phenylsuccinic acid (racPSA and S-PSA, respectively). In the second part, six new multicomponent crystals of baclofen (BAC, (RS) 4-amino-3-(4- chlorophenyl)-butanoic acid), were prepared with mono- and dicarboxylic acids: two pharmaceutical co-crystals obtained with benzoic acid (BAC•BA) and p-toluic acid (BAC•PTA) and four pharmaceutical salts with 1-hydroxy-2-naphthoic acid, (BAC+)(HNA-), oxalic acid, 2(BAC+)(OA2-), maleic acid, (BAC+)(MA-) and p-toluene sulfonic acid, (BAC+)(PTSA-)•IPA. The compounds prepared were analysed by single crystal and powder X-ray diffractometry, differential scanning calorimetry and their solubility was measured in water and ethanol. From the analysis of the model co-crystals it was concluded that their aqueous solubility is inversely related to the melting point values and this can be explained by packing features. Also, the introduction of a chiral building block, compared to its racemic counterpart, is a valuable way to limit the formation of the intermolecular interactions in the new multicomponent crystal and thus decrease the efficiency of the packing which eventually leads to lower melting points and better solubility. The analysis of the baclofen crystals suggests that a strong, robust and predictable hydrogen bonding network with a combination of molecular building blocks which show acceptable molecular flexibility is a good recipe for successful co-crystal design.
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Roberts, Jacintha. "Studies on bisphosphonate elution from orthopaedic implants." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112582.
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In a 6-week rat model it was demonstrated that a small dose of peri-implant zoledronic acid (ZA) increased local bone formation 3-fold compared with controls. Ancillary in vitro studies using 14C-labeled ZA implant doses demonstrated biphasic elution profiles for implants coated with hydroxyapatite; complete ZA release occurred within one to three weeks in serum compared with only 60% ZA release after 12 weeks in water. Implants without hydroxyapatite coating showed more burst-type release profiles and full ZA elution within 24 hours of hydration in serum or water. Canine studies at 6 weeks using implants with 14C-labeled ZA showed that the compound remained localized, with the greatest ZA concentration immediately adjacent to the implant. Although there was evidence of skeletal ZA distribution via diffusion into the circulation, the levels were two orders of magnitude less than at the implant site.
36
Zhu, Lingziao. "A cold atoms gravimeter for use in absolute gravity comparisons." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8152/.
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This thesis describes the construction of high precision absolute gravimeter, aiming at realising a comparison with a state-of-the-art gravimeter. The instrument is based on performing Raman atom interferometry on ensembles of laser-cooled 87Rb atoms in an atomic fountain. The highlight of this work is the demonstration of an IQ modulator based optical single-sideband (OSSB) laser system providing a highly coherent light source. The advantage this brings to atom interferometry is the suppression of the unwanted sidebands, eliminating interference effects, especially the spatially dependent Rabi frequency and the interferometric phase shift. Recently 5x106 atoms were launched at a rate of 0.5 Hz with a temperature of 10 �K. After improving the vibration isolation, we have observed interference fringes with a sensitivity of 225 �Gal/pHz. The preliminary accuracy is estimated to be 218 �Gal. A study of systematic noise and bias sources has been undertaken, �finding that the limitation of the above performance is the vibration noise and Coriolis effect, respectively. The apparatus has been transported to NERC Space Geodesy Facility in Herstmonceux, where a comparison campaign is in preparation.
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Meyer, Kevin J. "The relationship between therapists' use of humor and therapeutic alliance." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1186189837.
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Cowell, Richard Pennant Wynn. "Studies on the therapeutic use of pacing in myocardial dysfunction." Thesis, Imperial College London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299473.
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Zhang, Xiao, and 張瀟. "The effects of l-tetrahydropalmatine and rhynchophylline, alkaloids derived from herbal medicines, on cellular and molecular neurotoxicityof cocaine in PC12 cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43572248.
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Wang, Ning Michael, and 王宁. "The preventive and curative potential of berberine and coptis on humanhepatocellular carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48079637.
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Hepatocellular carcinoma (HCC) is the primary cancer of liver. It is the fifth common malignant tumor in men while seventh common in women. Aetiology of HCC is complex; however, it is now believed that sustained chronic liver injury and fibrosis are critically involved in the development of HCC. Prevention and treatment of HCC is far from desirable and prognosis remains poor. Coptis is a Chinese herbal Medicine which has been used for more than thousands years for clearing heats, dampness and toxics. Recently, studies from our group reported the hepatoprotective effect of Coptis and its major active component, berberine, on acute liver injury and berberine was extensively studied for their anti-tumor effect. However, there’s no comprehensive investigation focusing on the preventive and curative potential of berberine on HCC. Hence, here we hypothesized Coptis and berberine exhibits both preventive and curative effects on HCC. The prevention of HCC by berberine and Coptis may rely on their effects on chronic liver damage and fibrosis, and the curative action may depend on their actions on the angiogenesis, tumor growth and invasion of HCC. Both in vitro cell models and in vivo animal system were used in our study and some molecular events were investigated. We found that berberine and Coptis could significantly attenuate the chronic liver injury and fibrosis by restoring the anti-oxidative enzyme SOD activity in CCl4-, bile duct ligation- and alcohol-induced liver injury and fibrosis model. Recovery of SOD activity prevents the hepatocytes from apoptosis by inhibiting the oxidative stress-induced Erk1/2 signaling activation. The prevention of berberine and Coptis on chronic liver injury and fibrosis may contribute to its preventive effect against HCC. Then we found that berberine (as representative to Coptis) could suppress the angiogenesis of HCC, in which berberine does not directly act on the blood vessel formation, but suppress the expression and secretion of pro-angiogenic factors VEGF in HCC cells, and Id-1 inhibition by berberine plays a central role in the suppression of HIF-1α/VEGF and NF-κB pathways. We also found that berberine could induce both apoptotic and autophagic cell death in HCC, and the mitochondria related-caspases activation confers the apoptosis while mTOR inhibition initiates autophagy in berberine treated- cells. We found that berberine could suppress the migration and invasion of HCC cells as well, and Rho-GTPases/ROCK signaling is the particular target in berberine’s anti-invasive action. Finally, to dig out some molecular events involved in berberine’s action on HCC, we studied critically the mechanism underlying berberine’s inhibition on Cyclin D1 in HCC. We found berberine may promote the IKKα-induced Cyclin D1 phosphorylation at T286, and this may initiate the ubiquitination-dependent proteasomal degradation of Cyclin D1 in berberine-treated HCC cells and contribute to berberine’s anti-HCC action. Critical clinical trials and OMICS techniques were planned to further our comprehensive study on Coptis and berberine’s effects on HCC. In all, we found that berberine targets on different stages and molecules and exerts preventive and curative potential against HCC. Our study sheds light on the clinical application of berberine in HCC treatment.published_or_final_version
Chinese Medicine
Doctoral
Doctor of Philosophy
41
Chan, Chung-ling Pansy, and 陳鍾靈. "The long-term effects of yoga and aerobic exercise on cognitive function and clinical symptoms in early psychosis : a follow-up randomized control trial." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206585.
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Background: A study of the impact of yoga and aerobic exercise and psychosis was conducted in 2012 by Lin et al., from The University of Hong Kong. The study indicated significant improvement in the aspects of physical fitness, cognitive functions, psychosocial and emotional functioning in patients with psychosis after a 12-week yoga or aerobic intervention program. Long-term effect of exercise intervention, however, had yet been determined. The aim of the present study was to evaluate the long-term effects of yoga and aerobic exercise on cognitive functioning and clinical symptoms in early psychosis. Patients who originally participated in Lin et al.’s 2012 study were recruited and re-assessed in this current 18-month follow-up study.
Methods: Two intervention groups (yoga and aerobic exercise group) and one control group (wait-list control group) of a total 57 subjects from the initial study were recruited in this follow-up study. Cognitive functioning and clinical symptoms were assessed at three time points (T1:Baseline, T2:12-week, T3:18-month).
Results: No significant changes or significant deterioration were found in cognitive functioning, clinical symptoms and depression between T2 (12-week) and T3 (18-month) in both intervention groups (yoga and aerobic group). Significant improvement of clinical symptoms was observed in wait-list control group at T3.
Conclusions: Although there is no significant finding in this current study, it is still recommended that further study on the relationship between physical exercise intervention and psychosis should carried out in order to explore other adjunct, and especially low cost, treatment to antipsychotics in treating people with psychosis.published_or_final_version
Psychological Medicine
Master
Master of Psychological Medicine
42
Hall, Clifford Michael. "Relative efficacy of hydrocortisone and methylprednisolone in acute severe asthma." Thesis, University of Cape Town, 1993. http://hdl.handle.net/11427/25562.
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Boxhammer, Veronika [Verfasser], and Gregor [Akademischer Betreuer] Morfill. "Developmant of a safe therapeutic window for cold atmospheric plasma treatments / Veronika Boxhammer. Betreuer: Gregor Morfill." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2014. http://d-nb.info/1065610483/34.
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Carvalho, George. "Studies on the inotropic effect of insulin and glucose : a new diet for the ischemic heart?" Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101840.
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The present project investigated the effect of glucose, high dose insulin and normoglycemia (GIN) therapy in patients undergoing coronary revascularization surgery. A reduction in myocardial injury as measured by cardiac troponin I was the primary end point. Cardiac function based on hemodynamics and vasoactive drug requirements as well as clinical outcome were evaluated. Hormones and metabolites and cardiac metabolism were investigated concurrently as potential mechanisms of GIN therapy. The major findings of the present study are that GIN therapy reduced post-operative myocardial injury and myocardial dysfunction leading to a decrease in major complications following coronary artery bypass grafting surgery. The mechanism of the overall improvement in cardiac function and decreased morbidity following CABG with GIN therapy is likely to be multi-factorial, but from the present results, is influenced by improved myocardial metabolism. GIN therapy is thus an effective diet for the ischemic heart.
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Braun, Marle. "Total antioxidant capacity of stewed tomato and onion flavoured with parsley: effect of thermal household processing." Thesis, Cape Peninsula University of Technology, 2006. http://hdl.handle.net/20.500.11838/766.
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Thesis (MTech (Consumer Sciences: Food and Nutrition))--Cape Peninsula University of Technology, 2006Fruit and vegetables are the major antioxidant contributors to the diet Antioxidants assist in the prevention of oxidative damage in the body and may as a result prevent the causation of degenerative diseases. Thermal household processing plays an integral part in South African consumers' lives, as most fruit and vegetables consumed are processed at home. Consumers' perceptions that food processing causes nutrient losses, especially of vitamin C, have been corroborated by studies that investigated thermal household processing of single foods or that of industrial processing. No studies have determined the effect of thermal household processing on mixed dishes. A popular consumed South African mixed dish, namely, stewed tomato and onion flavoured with parsley, was investigated by using three recipes, each using a different preparation method. The traditional recipe for the preparation of stewed tomato and onion was modified (control recipe) to contain parsley. Two other recipes (Recipe 1 and 2) were compiled based on the recipe formulation of the control recipe but differed in the preparation methods used. In Recipe 1, raw onion was added to cooked tomato and in Recipe 2, sauteed onions were added to cooked tomato.
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Hu, Yaxin, and 胡亞欣. "Biophysical interactions between therapeutic ultrasound and live cell." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/208032.
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Therapeutic ultrasound employs the acoustic energy carried by high-frequency mechanical wave to induce beneficial effects on living systems. This therapeutic approach is advantageous in that its energy could be remotely focused on the targeted tissue in a non-invasive manner. Although ultrasound therapy has been shown to be feasible and effective in both laboratory experiments and clinical trials, its safety and efficacy are still challenged by the lack of fundamental knowledge of how ultrasound wave exerts physical effects on the cell system and how the cell functionally responds to the ultrasound stimulation. Motivated by the above insight, this thesis aims to provide direct experimental evidence for illustrating the biophysical details of how ultrasound wave (alone or combined with microbubble) interacts with live cells.
An acoustic experimental platform with well-calibrated ultrasound field and live-cell imaging modality was developed to observe ultrasound-cell interaction. Based on this platform, a series of single-cell studies was then conducted to monitor the structural and functional changes of the live cell as well as its fluorescently-labelled components over the course of ultrasound exposure. Results obtained in this thesis provided image-level evidence for characterizing the ultrasound-cell interactions in the following three aspects. First, it was found that low-intensity ultrasound pulsing could directly perturb the plasma membrane, the cytoskeletal
network and the inner nucleus of live neuroblastoma cells. This cytomechanical perturbation would result in reversible and structural alternations of subcellular components. Second, low-intensity pulsed ultrasound, when applied on neuronal cells, could exert morphological impact through inducing neurite retraction and cell body displacement, and electrophysiological impact in the form of membrane depolarization and calcium influx. This finding verified the potential of ultrasound in modulating neuronal development and excitability. Last, the cell membrane perforation and resealing dynamics induced by the ultrasound-activated microbubble were visualized and characterized. The subsequent cellular responses to this ultrasound-induced sonoporation were also identified at both membrane and cytoskeleton levels.
The significance of this study is to provide direct and solid experimental evidence for understanding the biophysical interactions between ultrasound wave and live cell. This advanced scientific interpretation is definitely crucial for establishing the cellular mechanisms of therapeutic ultrasound and for providing technical insights into ultrasound treatment.published_or_final_version
Electrical and Electronic Engineering
Doctoral
Doctor of Philosophy
47
Zhang, Jingxuan, and 张静璇. "Therapeutic landscape in high-density urban environment." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B4754479X.
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Hong Kong’s compacted urban form brings about potential problems including mental illness. Meanwhile stressful life mainly originates from working pressure brought a lot of physical and mental problems for the people themselves and generating serious family and social problems. As more and more people start to aware mental health issue, the current mental health services system is no longer sustainable due to increasing number of patients. This thesis aims to excavate the potential for landscape to become element in healthcare delivery in the context of community as following: refine the definition of therapeutic landscape, define the scope of work, and identify components essential for therapeutic environment. Last but not least, dig out possible interpretation/physical form through set an example of a particular design introduce for a typical site.
Therapeutic landscape which introduce to community recreation system will become a new approach to backup mental health service system as well provide people more convenient and broad healthcare service to cultivate healthy personality. Thus promote community organic development to become a thoughtful and institutional environment.published_or_final_version
Architecture
Master
Master of Landscape Architecture
48
Peternelli, Loris. "The relationship between emotionality and in-session therapeutic phenomena." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0019/NQ37011.pdf.
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Morling, Stig. "SBR-technology - use and potential applications for treatment of cold wastewater." Doctoral thesis, KTH, Mark- och vattenteknik, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-10550.
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Biological nutrient removal is used as an indicator of SBR performance at nine different SBRplants operated for a long period at low water temperatures (5 – 10oC). Typically needed aeratedSRT (Solids Residence Time) for complete nitrification is found to be in the range of 6 – 10 days.Biological phosphorus removal has been found to take place at 5oC. The specific nitrification and denitrification rates (g N/kg VSS/h) have been found to besubstantially higher than those found in design recommendations. At temperatures < 10 oC thenitrification rates have been found up to 4 g Nox/kg VSS/h. It has also been possible to establish a relation between the COD/N ratio and the nitrificationrate, showing that the rate increases to high rates when the ratio decreases. Enhanced biological phosphorus removal has been demonstrated at two different plants even atlow water temperatures 5 – 7 oC. Efficient biological nitrogen removal and phosphorus removal has been demonstrated at bothlow water temperatures and in presence of very high Chromium concentrations in inlet water, upto 20 mg Cr/l. The plants operated with a short fill time in comparison with the total cycle time for the SBRprocess have all demonstrated good sludge settling properties, suggesting that the SBR processmay incorporate a good sludge selection performance. Once a flexible operation strategy has been installed (in most cases through PLC systems) it hasbeen possible to meet load variations to maintain good treatment results. This has been found tobe true for most of the plants included in the thesis. Finally, a modified way to assess the energy efficiency for the system is analysed and suggested.Instead of using the traditional ratio kWh/kg BODremoved the use of kWh/kg OCPremoved as a basisfor energy efficiency is used as a far more relevant efficiency measurement.QC 20100803
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Chan, Wing-yan Veronica, and 陳詠恩. "An examination of neuroprotective effects of 17B-estradiol and extracts from Panax Quinquefolius L., Ginkgo Biloba and HypericumPerforatum against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)induced nigral-striatal neuronal degeneration." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B3122720X.
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