Relevant bibliographies by topics / Therapeutic Use Quinine

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Therapeutic Use Quinine'

Author: Grafiati
Published: 4 June 2021
Last updated: 28 July 2025

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Journal articles on the topic "Therapeutic Use Quinine"

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Eyal, Sara. "The Fever Tree: from Malaria to Neurological Diseases." Toxins 10, no. 12 (2018): 491. http://dx.doi.org/10.3390/toxins10120491.

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This article describes the discovery and use of the South American cinchona bark and its main therapeutic (and toxic) alkaloids, quinine and quinidine. Since the introduction of cinchona to Europe in the 17th century, it played a role in treating emperors and peasants and was central to colonialism and wars. Over those 400 years, the medical use of cinchona alkaloids has evolved from bark extracts to chemical synthesis and controlled clinical trials. At the present time, the use of quinine and quinidine has declined, to a large extent due to their toxicity. However, quinine is still being pres
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Izaguirry, Aryele Pinto, Natasha Frasson Pavin, Melina Bucco Soares, et al. "Effect of quinine-loaded polysorbate-coated nanocapsules on male and female reproductive systems of rats." Toxicology Research 5, no. 6 (2016): 1561–72. http://dx.doi.org/10.1039/c6tx00203j.

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Murakami-Kubo, Ikuko, Katsumi Doh-ura, Kensuke Ishikawa, et al. "Quinoline Derivatives Are Therapeutic Candidates for Transmissible Spongiform Encephalopathies." Journal of Virology 78, no. 3 (2004): 1281–88. http://dx.doi.org/10.1128/jvi.78.3.1281-1288.2004.

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ABSTRACT We previously reported that quinacrine inhibited the formation of an abnormal prion protein (PrPres), a key molecule in the pathogenesis of transmissible spongiform encephalopathy, or prion disease, in scrapie-infected neuroblastoma cells. To elucidate the structural aspects of its inhibiting action, various chemicals with a quinoline ring were screened in the present study. Assays of the scrapie-infected neuroblastoma cells revealed that chemicals with a side chain containing a quinuclidine ring at the 4 position of a quinoline ring (represented by quinine) inhibited the PrPres forma
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El Ket, Nermine, Eric Kendjo, Marc Thellier, et al. "Propensity Score Analysis of Artesunate Versus Quinine for Severe Imported Plasmodium falciparum Malaria in France." Clinical Infectious Diseases 70, no. 2 (2019): 280–87. http://dx.doi.org/10.1093/cid/ciz206.

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Abstract Background Little is known on the use of artesunate compared with quinine for the treatment of imported malaria cases in nonendemic countries with a high level of care. Therefore, we compared the 2 treatments in terms of mortality and hospital and intensive care unit (ICU) discharge rates. Methods We analyzed the cohort of all severe imported malaria patients reported to the French National Reference Center from 2011 to 2017. After controlling for differences between quinine- and artesunate-treated individuals using the inverse probability of treatment weighting method, 28-day mortali
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Dou, Kai, Rikang Wang, Weili Bao, et al. "Quinine-Hemin Compound As an Anti-Inflammatory Therapy in Sickle Cell Disease." Blood 144, Supplement 1 (2024): 1108. https://doi.org/10.1182/blood-2024-205840.

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Free hemin released during intravascular hemolysis induces inflammatory responses and plays a pivotal role in the pathogenesis of various hemolytic disorders, including sickle cell disease (SCD). Several strategies including the use of hemopexin have been developed to eliminate or inactivate the pro-inflammatory effects of free hemin. Compared to biologic drugs, small molecule drugs are more affordable, which is critical for the SCD patient cohort. Several hemin binding small molecule drugs, including quinine derivatives, have been developed and approved by FDA as malaria therapies, but it is
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Hackler, László, Márió Gyuris, Orsolya Huzián, et al. "Enantioselective Synthesis of 8-Hydroxyquinoline Derivative, Q134 as a Hypoxic Adaptation Inducing Agent." Molecules 24, no. 23 (2019): 4269. http://dx.doi.org/10.3390/molecules24234269.

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Hypoxia is a common feature of neurodegenerative diseases, including Alzheimer’s disease that may be responsible for disease pathogenesis and progression. Therefore, the hypoxia-inducible factor (HIF)1 system, responsible for hypoxic adaptation, is a potential therapeutic target to combat these diseases by activators of cytoprotective protein induction. We have selected a candidate molecule from our cytoprotective hydroxyquinoline library and developed a novel enantioselective synthesis for the production of its enantiomers. The use of quinidine or quinine as a catalyst enabled the preparation
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Setz, Christian, Pia Rauch, Melanie Setz, Stephan Breitenberger, Stephan Plattner, and Ulrich Schubert. "Synergistic Antiviral Activity of European Black Elderberry Fruit Extract and Quinine Against SARS-CoV-2 and Influenza A Virusa." Nutrients 17, no. 7 (2025): 1205. https://doi.org/10.3390/nu17071205.

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Background/Objectives: The persistent threat of emerging respiratory RNA viruses like SARS-CoV-2 and Influenza A virus (IAV) necessitates the continuous development of effective, safe, broadly acting, and generally accessible antiviral agents. Current treatments often face limitations such as early administration requirements, resistance development, and limited global access. Natural products, like European black elderberry (Sambucus nigra L.; S. nigra) fruit extract and quinine, have been used historically against viral infections. In this study, we investigated the antiviral efficacy of a s
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Lamkhade, Snehal* Shelke Pranali Dr. Wakale Vijaykumar S. "A Brief Review on Quinine Sulphate Sustained Release Tablet." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 4558–64. https://doi.org/10.5281/zenodo.15527245.

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Malaria continues to pose a significant global health burden, particularly in developing regions with limited healthcare access. Conventional antimalarial therapies, while effective, suffer from limitations such as short drug half-lives, poor patient compliance, and the rising threat of drug resistance. In response to these challenges, sustained release (SR) tablet formulations are emerging as a promising strategy to optimize antimalarial drug delivery. This review paper presents a comprehensive overview of the formulation approaches, materials used, pharmacokinetic benefits, and clinical impl
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Mahajan, Akhil, and Tejpal Singh Chundawat. "Review on the Role of the Metal Catalysts in the Synthesis of Pharmacologically Important Quinoline Substrate." Mini-Reviews in Organic Chemistry 16, no. 7 (2019): 631–52. http://dx.doi.org/10.2174/1570193x15666181001142122.

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Quinoline stands out amongst the most essential N-based heterocyclic biologically active compounds. Friedlieb Ferdinand Runge was first to isolate quinoline from coal tar in 1834. Chemical component, quinine found in the bark of cinchona tree was used for treatment of malaria in the year of 1820. Quinoline derivatives have been found to exhibit different therapeutic activities such as antimalarial, antibacterial, antifungal, antiplatelet, anticancer, antitubercular, etc. There are a couple of promising compounds with the Quinoline skeleton like Pamaquine, Chloroquine, Tafenoquine, Bulaquine, Q
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Dziekan, Jerzy M., Han Yu, Dan Chen, et al. "Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay." Science Translational Medicine 11, no. 473 (2019): eaau3174. http://dx.doi.org/10.1126/scitranslmed.aau3174.

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Mechanisms of action (MoAs) have been elusive for most antimalarial drugs in clinical use. Decreasing responsiveness to antimalarial treatments stresses the need for a better resolved understanding of their MoAs and associated resistance mechanisms. In the present work, we implemented the cellular thermal shift assay coupled with mass spectrometry (MS-CETSA) for drug target identification inPlasmodium falciparum, the main causative agent of human malaria. We validated the efficacy of this approach for pyrimethamine, a folic acid antagonist, and E64d, a broad-spectrum cysteine proteinase inhibi
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Dissertations / Theses on the topic "Therapeutic Use Quinine"

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Vezmar, Marko. "Pharmacological effects of quinoline-related compounds in human tumour cells overexpressing the multidrug resistance protein (MRP)." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0003/MQ37175.pdf.

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Liebman, Katherine May. "New 4-Aminoquinoline Compounds to Reverse Drug Resistance in P. falciparum Malaria, and a Survey of Early European Antimalarial Treatments." PDXScholar, 2014. http://pdxscholar.library.pdx.edu/open_access_etds/2114.

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Intermittent fevers caused by Plasmodium parasites have been known for millennia, and have caused untold human suffering. Today, millions of people are afflicted by malaria each year, and hundreds of thousands die. Historically, the most successful synthetic antimalarial drug was chloroquine, as it was safe, inexpensive, and highly efficacious. However, plasmodial resistance to chloroquine now greatly limits its utility. Previously in our laboratories it has been shown that attachment of a "reversal agent moiety" to the side chain of chloroquine can result in the restoration of activity agains
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Mello, Mônika Conchon Ribeiro de. ""Avaliação da resposta clínica e citogenética em portadores de leucemia mielóide crônica, tratados com inibidor da tirosina quinase (imatinib)"." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/5/5136/tde-11082005-150129/.

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O STI (imatinib, Glivec) é um inibidor da tirosina quinase BCR-ABL, responsável pela patogênese da leucemia mielóide crônica (LMC). Um total de 110 pacientes com LMC na fase crônica (FC) que falharam ou foram intolerantes ao tratamento com interferon, fase acelerada (FA) e crise blástica (CB) foram tratados com imatinibe entre dezembro de 2000 e setembro de 2003. Resposta hematológica completa e resposta citogenética maior foram observadas em 95,9% e 69,4% respectivamente em pacientes em FC e 93,2% e 36,4% em FA. Apenas 2 pacientes na CB estão vivos. O imatinib foi bem tolerado com altas taxas
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Arevalo, Iracema. "Cutaneous leishmaniasis : iNOS gene expression and a novel immunomodulatory therapy." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=31183.

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Nitric oxide (NO) has been shown to be lethal for a variety of intracellular pathogens including Leishmania. In murine models, the inducible nitric oxide synthase gene (iNOS) is expressed in activated macrophages and is involved in the synthesis of NO. Because the role of NO and iNOS in human leishmaniasis was less clear, we examined the expression of the iNOS gene in human macrophages infected with Leishmania in vitro and in biopsy tissue from subjects with cutaneous leishmaniasis.<br>Pentavalent antimony (Sb5+) in the form of Pentostam(TM) or Glucantime(TM) is still the treatment of choice d
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Cardoso, Leandro 1979. "Utilização farmacológica de um composto inédito derivado de quinazolina como inibidor potencial da quinase de adesão focal (FAK) no processo de hipertrofia cardíaca em camundongo = Pharmacological use of a novel compound quinazoline derivative as potential inhibitor of the focal adhesion kinase in the process of cardiac hypertrophy in mice." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310205.

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Orientador: Kleber Gomes Franchini<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-20T23:08:02Z (GMT). No. of bitstreams: 1 Cardoso_Leandro_M.pdf: 3831901 bytes, checksum: 40e5df211d7e6fd923f654bd8d3a1ec1 (MD5) Previous issue date: 2012<br>Resumo: Nas doenças do coração ocorre hipertrofia e remodelamento do ventrículo esquerdo com impacto negativo na evolução clínica. Esses fatores influenciam independentemente o risco cardiovascular por elevarem a predisposição a infartos do miocárdio, ao desenvolvimento de
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Books on the topic "Therapeutic Use Quinine"

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Ortiz-Crespo, Fernando Ignacio. La corteza del árbol sin nombre: Hacia una historia congruente del descubrimiento y difusión de la quina. Fundación Fernando Ortiz Crespo, 2002.

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Honigsbaum, Mark. The fever trail: In search of the cure for malaria. Farrar, Straus and Giroux, 2002.

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Saul, Jarcho, ed. Tractatus simplex de cortice Peruuiano =: A Plain treatise on the Peruvian bark : the Stanitz manuscript. Francis A. Countway Library of Medicine, 1992.

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Rocco, Fiammetta. The miraculous fever tree: Malaria and the quest for a cure that changed the world. HarperCollins, 2003.

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Khujah, Husayn. al-Asrar al-kaminah bi-ahwal al-Kinah Kinah (Tahqiq al-nusus). al-Majma al-Tunisi lil-Ulum wa-al-Adab wa-al-Funun, Bayt al-Hikmah, 1993.

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Honigsbaum, Mark. The Fever Trail. Macmillan, 2001.

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Jarcho, Saul. A Plain Treatise on the Peruvian Bark (The Stanitz Manuscript/Tractatus Simplex De Cortice Peruviano). Science History Pubns, 1993.

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Honigsbaum, Mark. The Fever Trail: In Search of the Cure for Malaria. Farrar, Straus and Giroux, 2002.

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Fever Trail: In Search Of The Cure For Malaria. Diane Pub Co, 2004.

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The fever trail: The hunt for the cure for malaria. Macmillan, 2001.

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Book chapters on the topic "Therapeutic Use Quinine"

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Ursul Jean-Paul N’guessan, Deto, Songuigama Coulibaly, Apleheni Eunice Melissa Adouko, and Mahama Ouattara. "Antimalarial Drugs with Quinoline Nucleus and Analogs." In Infectious Diseases. IntechOpen, 2023. http://dx.doi.org/10.5772/intechopen.113193.

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Quinoline core antimalarials are a major class used for the management of uncomplicated malaria in combination with artemisinin derivatives. Moreover, despite its adverse effects, Quinine remains the reference molecule in the treatment of cerebral malaria due to Plasmodium falciparum. This class also contains molecules such as Mefloquine used in the prevention of malaria. In addition, synthetic derivatives are more manageable with greater therapeutic margins and fewer adverse effects. They have an interest in avoiding the spread of resistance, especially with derivatives possessing gametocytoc
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Safdar, Naila, Azra Yasmin, and Zulqurnain Khan. "Medicinal Plants: Traditional Trends to Modern Therapeutics." In Medicinal Plants: Microbial Interactions, Molecular Techniques and Therapeutic Trends. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815136838123010015.

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Medicinal plant therapies are becoming more common, as more people seek natural cures and health approaches devoid of synthetic chemicals' adverse effects. The biological and pharmacological potential of plants is studied and utilized all around the globe for various purposes including the treatment of infections and diseases owing due to bioactive compounds in plants produced as a result of secondary metabolism. The study of medicinal plants is helpful in clinical trials to find pharmacologically useful chemicals, and this method has produced thousands of valued medicines. Opium, aspirin, qui
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Dhiman, Sukhvinder, Gulshan Kumar, Ajay Kumar, Sapna Devi, Sonika, and Manoj Kumar. "Anthraquinones as Bioactive Agents: Recent Trends and Developments in Phytotherapy." In Anthraquinones: Bioactive Multifaceted Therapeutic Agents. BENTHAM SCIENCE PUBLISHERS, 2025. https://doi.org/10.2174/9789815313987125030006.

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Anthraquinones are organic compounds and members of the Quinone family comprising 9, 10-anthracenedione core. Anthraquinone is a chemical scaffold that has been employed for many years in a variety of therapeutic applications such as antimicrobial, anticancer, diuretic, anti-inflammatory, and phytoestrogen activities. Anthraquinones are commonly produced as secondary metabolites in various higher plant species (senna, buckthorn, yellow dock) or they can either be synthesized using chemical routes such as the condensation of 1, 4-naphthoquinone with butadiene, naphthalene oxidation, anthracene
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Barman, Pankaj, and Anupam Biswas. "The Contribution of Traditionally Used Medicinal Plants to Modern Medicine: An Update on the Successful Journey of Medicinal Plants of North East Africa." In Traditional Medicine in North East Africa: Research on Traditional Healer Preparations and Herbs. BENTHAM SCIENCE PUBLISHERS, 2025. https://doi.org/10.2174/9789815313178125010010.

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Traditional herbal treatments have a long history and are highly valued in South Africa. Many North-East African medicinal plants have been found to have a broad range of pharmacological characteristics by using ethnobotanical knowledge as a guide. In this chapter, some successful bioprospecting of phytochemicals formulation &amp; compounds from medicinal plants of North-East African medicinal plantsis highlighted by following the advantages of the medicinal application, status of preclinical &amp; clinical study, and development as a commercial drug. Drugs like Artemisinin, resveratrol, Berbe
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R., Vimalavathini, Sittarthan V., and Kavimani S. "Molecular Basis of Therapeutic Action of Flavonoids." In Therapeutic Insights into Herbal Medicine through the Use of Phytomolecules. BENTHAM SCIENCE PUBLISHERS, 2024. http://dx.doi.org/10.2174/9789815238129124030006.

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Herbs have been an integral part of human life for ages. Modern allopathic drugs had an upper hand over traditional medicine in the past century due to their mounting inefficacy, resistance, cost, and adverse effects that have led to the reclaim of herbs once again. Herbs holistically confer biological activity due to the presence of phytochemicals, which are classified broadly as carbohydrates, lipids, terpenoids, alkaloids, polyphenols, and essential and volatile oils. In this, polyphenols are a vast group further comprising flavonoids, phenolic acid, stilbenoids, tannins, lignans, xanthones
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Campos-Xolalpa, Nimsi, Julia Pérez-Ramos, Ana Esquivel-Campos, Cuauhtemoc Pérez-González, Leonor Sánchez-Pérez, and Salud Pérez-Gutiérrez. "Cytotoxic and Antimicrobial Activities of Quinones Isolated from Different Organism." In Cytotoxicity - New Insights into Toxic Assessment. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.95598.

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Cancer is a group of related diseases in which there is uncontrolled cell growth that spreads to the surrounding tissues and damages them. Cancer remains the disease with the leading cause of death worldwide, and incidence and mortality are increasing rapidly. The main cancer treatment is chemotherapy; however, the compounds used in this treatment have serious side effects for this reason, is necessary to develop new therapeutic strategies. Natural products are an excellent pharmacological alternative for the treatment of cancer and infections. In search of new compounds with cytotoxic and ant
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Senthilkumar, Madhura, Suganya Meganathan, Vadivukkarasi Sasikumar, Gokul Sakthivel, and Dhevikarunaa Govindaraju Malmarugan. "Identification of Phytochemical Compounds from Lawsonia inermis Leaves against Hbx Protein of Hepatitis B Virus: An In Silico Analysis." In Therapeutic Plants: Recent Advances in the Use of Herbs as Alternative Medications. BENTHAM SCIENCE PUBLISHERS, 2025. https://doi.org/10.2174/9789815322910125010016.

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Plants have many medicinal properties, and they play a major role in drug discovery nowadays. Lawsonia inermis is commonly known as Henna and has numerous medicinal properties. Lawsonia inermis (Family: Lythraceae) contains carbohydrates, phenolics, flavonoids, saponins, proteins, alkaloids, terpenoids, quinones, coumarins, xanthones, fat, resin, and tannins. The pharmacological studies showed that Lawsonia inermis has antibacterial, antifungal, antiparasitic, antioxidant, hepatoprotective, central nervous, analgesic, anti-inflammatory, antipyretic, wound and burn healing, immunomodulatory, an
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Zeeshan Bhatti, Muhammad, Hammad Ismail, and Waqas Khan Kayani. "Plant Secondary Metabolites: Therapeutic Potential and Pharmacological Properties." In Secondary Metabolites - Trends and Reviews [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.103698.

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Plants are an essential source for discovering novel medical compounds for drug development, and secondary metabolites are sources of medicines from plants. Secondary metabolites include alkaloids, flavonoids, terpenoids, tannins, coumarins, quinones, carotenoids, and steroids. Each year, several new secondary metabolites are extracted from plants, providing a source of possibilities to investigate against malignant illnesses, despite certain natural chemicals having distinct anticancer activities according to their physicochemical features. Secondary metabolites found in plants are frequently
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Mandal, Rupam. "Account of Aloe barbadensis: Emphasizing Phytochemistry and Antibacterial Potential in Darjeeling Himalayas." In Progress in Chemical and Biological Science. Lincoln University College, Malaysia, 2023. http://dx.doi.org/10.31674/book.2023pcbs001.

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Plants have been widely used throughout human history as a basis for medical treatment. Ethnobotany, the study of traditional human uses of plants, is recognized as an effective way to discover future medicines. The Darjeeling Himalayas are home to a huge number of medicinal plants used by the local people. Aloe barbadensis is a plant that grows in this area and has a long history of being used as a medicinal plant with diverse therapeutic applications. The study was conducted to determine the phytochemical properties of the leaves of the plant. Flavonoidsce or absence of alkaloids, tannin, gl
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Bisen, Chandrakant, Yashpal Rathod, Anup Parmar, and Wasudeo B. Gurnule. "APPLICATION OF COMBINATORIAL TOOLS TO ANTI-TUBERCULOSIS DRUG." In Futuristic Trends in Chemical Material Sciences & Nano Technology Volume 3 Book 18. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bdcs18ch18.

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The molecules whose biological characteristics are known are carefully considered as a known set for the purpose of developing regression analysis models at the beginning of this chapter. The data warrior programme was used to compute the descriptors for the known collection. The invention and enhancement of novel quinoline compounds allowed for the calculation of their descriptors. The biological activities of novel compounds were also determined using the regression analysis technique. Additionally, the molecular docking approach may be used to conduct inhibition tests for 1QPQ and 1KNC to c
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Conference papers on the topic "Therapeutic Use Quinine"

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Guilherme Semedo, Maria, João Rui Pita, and Ana Leonor Pereira. "Quality assessment of quinine sulfate samples in 19th and early 20th centuries in Portugal: the role of the Lusitanian Pharmaceutical Society." In 46th INTERNATIONAL CONGRESS FOR THE HISTORY OF PHARMACY. Pharmaceutical Association of Serbia, 2024. http://dx.doi.org/10.46793/ishp46.155s.

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Cinchona bark-derived medicines such as quinine sulfate were the only effective and widely used antimalarial treatments until the mid-twentieth century. The aim of this communication is to find and discuss references to quality control of quinine sulfate samples in a Portuguese pharmaceutical journal. For this purpose, we analyzed the Jornal da Sociedade Pharmaceutica Lusitana (Journal of the Lusitanian Pharmaceutical Society). This was an important Portuguese journal, edited by the Lusitanian Pharmaceutical Society, a pharmacist’s organization (1838-1933). This journal reflects Portuguese pha
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