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Journal articles on the topic 'Therapeutic Use Quinine'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 July 2025

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1

Eyal, Sara. "The Fever Tree: from Malaria to Neurological Diseases." Toxins 10, no. 12 (2018): 491. http://dx.doi.org/10.3390/toxins10120491.

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This article describes the discovery and use of the South American cinchona bark and its main therapeutic (and toxic) alkaloids, quinine and quinidine. Since the introduction of cinchona to Europe in the 17th century, it played a role in treating emperors and peasants and was central to colonialism and wars. Over those 400 years, the medical use of cinchona alkaloids has evolved from bark extracts to chemical synthesis and controlled clinical trials. At the present time, the use of quinine and quinidine has declined, to a large extent due to their toxicity. However, quinine is still being pres

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Izaguirry, Aryele Pinto, Natasha Frasson Pavin, Melina Bucco Soares, et al. "Effect of quinine-loaded polysorbate-coated nanocapsules on male and female reproductive systems of rats." Toxicology Research 5, no. 6 (2016): 1561–72. http://dx.doi.org/10.1039/c6tx00203j.

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3

Murakami-Kubo, Ikuko, Katsumi Doh-ura, Kensuke Ishikawa, et al. "Quinoline Derivatives Are Therapeutic Candidates for Transmissible Spongiform Encephalopathies." Journal of Virology 78, no. 3 (2004): 1281–88. http://dx.doi.org/10.1128/jvi.78.3.1281-1288.2004.

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ABSTRACT We previously reported that quinacrine inhibited the formation of an abnormal prion protein (PrPres), a key molecule in the pathogenesis of transmissible spongiform encephalopathy, or prion disease, in scrapie-infected neuroblastoma cells. To elucidate the structural aspects of its inhibiting action, various chemicals with a quinoline ring were screened in the present study. Assays of the scrapie-infected neuroblastoma cells revealed that chemicals with a side chain containing a quinuclidine ring at the 4 position of a quinoline ring (represented by quinine) inhibited the PrPres forma

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4

El Ket, Nermine, Eric Kendjo, Marc Thellier, et al. "Propensity Score Analysis of Artesunate Versus Quinine for Severe Imported Plasmodium falciparum Malaria in France." Clinical Infectious Diseases 70, no. 2 (2019): 280–87. http://dx.doi.org/10.1093/cid/ciz206.

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Abstract Background Little is known on the use of artesunate compared with quinine for the treatment of imported malaria cases in nonendemic countries with a high level of care. Therefore, we compared the 2 treatments in terms of mortality and hospital and intensive care unit (ICU) discharge rates. Methods We analyzed the cohort of all severe imported malaria patients reported to the French National Reference Center from 2011 to 2017. After controlling for differences between quinine- and artesunate-treated individuals using the inverse probability of treatment weighting method, 28-day mortali

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Dou, Kai, Rikang Wang, Weili Bao, et al. "Quinine-Hemin Compound As an Anti-Inflammatory Therapy in Sickle Cell Disease." Blood 144, Supplement 1 (2024): 1108. https://doi.org/10.1182/blood-2024-205840.

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Free hemin released during intravascular hemolysis induces inflammatory responses and plays a pivotal role in the pathogenesis of various hemolytic disorders, including sickle cell disease (SCD). Several strategies including the use of hemopexin have been developed to eliminate or inactivate the pro-inflammatory effects of free hemin. Compared to biologic drugs, small molecule drugs are more affordable, which is critical for the SCD patient cohort. Several hemin binding small molecule drugs, including quinine derivatives, have been developed and approved by FDA as malaria therapies, but it is

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Hackler, László, Márió Gyuris, Orsolya Huzián, et al. "Enantioselective Synthesis of 8-Hydroxyquinoline Derivative, Q134 as a Hypoxic Adaptation Inducing Agent." Molecules 24, no. 23 (2019): 4269. http://dx.doi.org/10.3390/molecules24234269.

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Hypoxia is a common feature of neurodegenerative diseases, including Alzheimer’s disease that may be responsible for disease pathogenesis and progression. Therefore, the hypoxia-inducible factor (HIF)1 system, responsible for hypoxic adaptation, is a potential therapeutic target to combat these diseases by activators of cytoprotective protein induction. We have selected a candidate molecule from our cytoprotective hydroxyquinoline library and developed a novel enantioselective synthesis for the production of its enantiomers. The use of quinidine or quinine as a catalyst enabled the preparation

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Setz, Christian, Pia Rauch, Melanie Setz, Stephan Breitenberger, Stephan Plattner, and Ulrich Schubert. "Synergistic Antiviral Activity of European Black Elderberry Fruit Extract and Quinine Against SARS-CoV-2 and Influenza A Virusa." Nutrients 17, no. 7 (2025): 1205. https://doi.org/10.3390/nu17071205.

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Background/Objectives: The persistent threat of emerging respiratory RNA viruses like SARS-CoV-2 and Influenza A virus (IAV) necessitates the continuous development of effective, safe, broadly acting, and generally accessible antiviral agents. Current treatments often face limitations such as early administration requirements, resistance development, and limited global access. Natural products, like European black elderberry (Sambucus nigra L.; S. nigra) fruit extract and quinine, have been used historically against viral infections. In this study, we investigated the antiviral efficacy of a s

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Lamkhade, Snehal* Shelke Pranali Dr. Wakale Vijaykumar S. "A Brief Review on Quinine Sulphate Sustained Release Tablet." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 4558–64. https://doi.org/10.5281/zenodo.15527245.

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Malaria continues to pose a significant global health burden, particularly in developing regions with limited healthcare access. Conventional antimalarial therapies, while effective, suffer from limitations such as short drug half-lives, poor patient compliance, and the rising threat of drug resistance. In response to these challenges, sustained release (SR) tablet formulations are emerging as a promising strategy to optimize antimalarial drug delivery. This review paper presents a comprehensive overview of the formulation approaches, materials used, pharmacokinetic benefits, and clinical impl

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Mahajan, Akhil, and Tejpal Singh Chundawat. "Review on the Role of the Metal Catalysts in the Synthesis of Pharmacologically Important Quinoline Substrate." Mini-Reviews in Organic Chemistry 16, no. 7 (2019): 631–52. http://dx.doi.org/10.2174/1570193x15666181001142122.

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Quinoline stands out amongst the most essential N-based heterocyclic biologically active compounds. Friedlieb Ferdinand Runge was first to isolate quinoline from coal tar in 1834. Chemical component, quinine found in the bark of cinchona tree was used for treatment of malaria in the year of 1820. Quinoline derivatives have been found to exhibit different therapeutic activities such as antimalarial, antibacterial, antifungal, antiplatelet, anticancer, antitubercular, etc. There are a couple of promising compounds with the Quinoline skeleton like Pamaquine, Chloroquine, Tafenoquine, Bulaquine, Q

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Dziekan, Jerzy M., Han Yu, Dan Chen, et al. "Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay." Science Translational Medicine 11, no. 473 (2019): eaau3174. http://dx.doi.org/10.1126/scitranslmed.aau3174.

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Mechanisms of action (MoAs) have been elusive for most antimalarial drugs in clinical use. Decreasing responsiveness to antimalarial treatments stresses the need for a better resolved understanding of their MoAs and associated resistance mechanisms. In the present work, we implemented the cellular thermal shift assay coupled with mass spectrometry (MS-CETSA) for drug target identification inPlasmodium falciparum, the main causative agent of human malaria. We validated the efficacy of this approach for pyrimethamine, a folic acid antagonist, and E64d, a broad-spectrum cysteine proteinase inhibi

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Berríos-Cárcamo, Pablo, Mauricio Quezada, Daniela Santapau, et al. "A Novel Morphine Drinking Model of Opioid Dependence in Rats." International Journal of Molecular Sciences 23, no. 7 (2022): 3874. http://dx.doi.org/10.3390/ijms23073874.

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An animal model of voluntary oral morphine consumption would allow for a pre-clinical evaluation of new treatments aimed at reducing opioid intake in humans. However, the main limitation of oral morphine consumption in rodents is its bitter taste, which is strongly aversive. Taste aversion is often overcome by the use of adulterants, such as sweeteners, to conceal morphine taste or bitterants in the alternative bottle to equalize aversion. However, the adulterants’ presence is the cause for consumption choice and, upon removal, the preference for morphine is not preserved. Thus, current animal

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Adegbola, Adebanjo J., and Julius O. Soyinka. "Simultaneous Quantification of Ciprofloxacin, Quinine and 3-hyrdoxyquinine in Human Plasma using a HPLC Method." Asian Journal of Pharmaceutical Research and Health Care 8, no. 1 (2016): 11. http://dx.doi.org/10.18311/ajprhc/2016/673.

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Malaria has been shown to strongly predispose patients in areas of malaria endemicity to bacteremia with severe outcomes, thus justifying the use of antibiotics in combination with antimalarial therapy in patients with severe malaria. This study describes a High-Performance Liquid Chromatographic (HPLC) method for simultaneous determinations of Ciprofloxacin (CPN), Quinine (QN), and its major metabolite, 3-Hydroxyquinine (3-HQN), in human plasma. Following a simple precipitation with acetonitrile, chromatographic separation was achieved on a reversed-phase Agilent Zorbax (CN) column (5 μm, 150

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Nyakudya, Trevor T., Thulani Tshabalala, Rachael Dangarembizi, Kennedy H. Erlwanger, and Ashwell R. Ndhlala. "The Potential Therapeutic Value of Medicinal Plants in the Management of Metabolic Disorders." Molecules 25, no. 11 (2020): 2669. http://dx.doi.org/10.3390/molecules25112669.

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Metabolic syndrome (MetS) is a prevalent, multifactorial and complex disease that is associated with an increased risk of developing diabetes and other major cardiovascular complications. The rise in the global prevalence of MetS has been attributed to genetic, epigenetic, and environmental factors. The adoption of sedentary lifestyles that are characterized by low physical activity and the consumption of high-energy diets contributes to MetS development. Current management criteria for MetS risk factors involve changes in lifestyle and the use of pharmacological agents that target specific bi

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14

Butler, Anthony. "Artemisinin." HIMALAYA 39, no. 1 (2019): 219–28. https://doi.org/10.2218/himalaya.2019.7886.

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Malaria is a disease that has blighted humankind since early times. The first antimalarial treatment available to Europeans was the dried bark of the cinchona tree from Peru. The main problem in its use was adulteration by other material. The ‘active principle’ was first extracted in 1820 and named quinine. It was found to be a more powerful and reliable drug than cinchona bark. Once its chemical structure had been determined, it was possible to synthesize substances chemically related to quinine that were equally powerful but could be manufactured industrially. Mepacrine (atabrine) was amongs

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15

Diallo, Mamadou H., Ibrahima S. Baldé, Alpha B. Barry, et al. "Severe malaria during pregnancy at the maternity ward of the municipal medical center of Ratoma, Guinea-Conakry." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 10, no. 3 (2021): 853. http://dx.doi.org/10.18203/2320-1770.ijrcog20210699.

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Background: Gestational malaria remains a major public health problem in malarious areas. The objectives of this work were to describe the socio-demographic, clinical, paraclinical, therapeutic and prognostic characteristics of patients who developed severe malaria during pregnancy.Methods: It was a descriptive prospective study carried out in the maternity ward of Ratoma municipal medical center, which was carried out over a period of 6 months from 01 October 2018 to 31 March 2019. This study involved all pregnant women who had presented severe malaria according to WHO criteria.Results: The i

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Kiang, Karen M., Penelope A. Bryant, Delane Shingadia, Shamez Ladhani, Andrew C. Steer, and David Burgner. "The treatment of imported malaria in children: an update." Archives of disease in childhood - Education & practice edition 98, no. 1 (2012): 7–15. http://dx.doi.org/10.1136/archdischild-2011-301530.

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Since the 2010 publication in this journal of a review of the management of imported malaria for UK children, new evidence for the treatment of both severe and uncomplicated malaria has been published. This review discusses these new data and expands the scope of the previous review to include non-endemic countries outside of the UK. The results of the AQUAMAT trial in late 2010 and other studies have prompted the WHO to recommend that intravenous artesunate be used preferentially over quinine for the treatment of severe malaria caused by any Plasmodium species in both adults and children. Ora

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Senthilkumar, N., and R. Sumathi. "Profiling Bioactive Compounds in the Bark of Cinchona officinalis L. and Anti-arthritic Properties Thereof." Asian Journal of Biotechnology and Bioresource Technology 10, no. 3 (2024): 15–22. http://dx.doi.org/10.9734/ajb2t/2024/v10i3208.

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The bark samples of C. officinalis were collected from The Nilgiris district of Tamil Nadu. The collected samples were processed and extracted using methanol solvent. The extracts showed high yield of secondary metabolites especially alkaloids, phenols, flavonoids, steroids, terpenoids, sterols, quinones and tannins. Alkaloid content was very high in C.officinalis followed by phenol, flavonoid, steroid and Tannin. The secondary metabolites present in C. officinalis (Bark) were isolated, purified, identified and characterized using differential Chromatographic techniques such as TLC, HPLC and G

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Tang, Yu-Qing, Qian Ye, He Huang, and Wei-Yi Zheng. "An Overview of Available Antimalarials: Discovery, Mode of Action and Drug Resistance." Current Molecular Medicine 20, no. 8 (2020): 583–92. http://dx.doi.org/10.2174/1566524020666200207123253.

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: Malaria is one of the three most deadly infectious diseases in the world and seriously endangers human health and life. To reduce the public health burden of this disease, scientists have focused on the discovery and development of effective antimalarial drugs, from quinine and chloroquine to antifolates and artemisinin and its derivatives, which all play a profound role in the treatment of malaria. However, drugresistant strains of Plasmodium falciparum have emerged due to frequent use of antimalarials and have become increasingly resistant to existing antimalarial drugs, causing disastrous

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Inklebarger J, James Inklebarger J., Mr Giles Gyer, Nikiforos Galanis, Mr Jimmy Michael, and Dr Ghulam Adel. "Cinchona Bark For The Treatment Of Covid-19 Pnemonia: A Modern Review Of The Potential Anti-Viral Therapuetic Applications Of An Old Treatment." International Journal of Medical Science and Clinical invention 7, no. 05 (2020): 4795–801. http://dx.doi.org/10.18535/ijmsci/v7i05.02.

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PURPOSE: The Coronavirus 2019 (COVID-19) pandemic is an international public health emergency. Vaccines, and acute infection drugs are currently unknown, and when available, expense and distribution issues may impede distribution in undeserved areas. The aim of this systematic review was to summarize the evidence regarding cinchona bark (CB) for its potential anti-viral properties against COVID-19  STUDY DESIGN: A current literature and historical text review was conducted, limited to articles having full text or abstracts available in English, using Google Scholar, Pubmed-NCBI, Sc

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Nyirenda, James. "Rapid Smartphone-based Image Reading for Assessing Quality of Active Pharmaceutical Ingredients of Commonly Prescribed Drugs-Lusaka Zambia." Journal of Natural and Applied Sciences 6, no. 1 (2022): 50–62. http://dx.doi.org/10.53974/unza.jonas.6.1.743.

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Third world countries suffer from supply of substandard therapeutic drugs and due to lack of robust quality testing facilities, many of these drugs find themselves in the dispensaries and various outlets for over the counter purchase. In order to ensure quality, simple yet informative tests are available and one of them is high performance thin layer chromatography. High Performance Thin Layer Chromatography (HPTLC) coupled with image acquisition by TLC software application on a smart phone and analysis by freeware Digitally enhanced Thin Layer Chromatography (DeTLC) respectively was performed

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Dr., Shraddha Verma1 Pragya Pandey2 Rituparna Acharyya2 Meghna Singh2 Anuradha Mahapatra2 Arnab Roy*2 Aniruddha Basak3 Ritesh Kumar3 Akash Bhattacharjee3 Navneet Kumar3 Ayesha Memon3. "The Cultural Significance of Medicinal Plants in Literature and Traditional Medicine: A Review of Geographic Distribution, Health Benefits and Marketing Strategies." International Journal of Scientific Research and Technology 2, no. 3 (2025): 546–58. https://doi.org/10.5281/zenodo.15095026.

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Medicinal plants have formed the backbone of human healthcare systems since antiquity,&ensp;binding widely disparate cultures through a common dependence on medicinal plants, but also reflecting local practices. Here&ensp;we present a holistic review on the three interlinked cross-sectional domains of medicinal plants covering: their global distribution patterns, validated therapeutic potential, and developing commodification trends in modern economies. As per analysis, medicinal plants possess the range of adaptability in diverse ecosystems of the world, which goes from&ensp;tropical wet fore

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Sinwat, Suratsawadee, Panee Sirisa-ard, and Choosak Nithikathkul. "Application of Geographic Information System (GIS) and Comparison of Active Substances in Medicinal Plants Used in Malaria Treatment Based on Folk Medicine Wisdom in Sa Kaeo Province." International Journal of Innovative Research in Medical Science 9, no. 07 (2024): 453–62. http://dx.doi.org/10.23958/ijirms/vol09-i07/1936.

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Introduction: Malaria is a tropical disease caused by Plasmodium parasites. The parasite spreads to people through the bite of infected female Anopheles mosquitoes. Malaria occurs mainly in poor, tropical, and subtropical areas of the world. The use of traditional medicine/traditional healers is prominent among populations in low-income countries with malaria infection. This study investigated the use of medicinal plants in the treatment of malaria by traditional healers. As well as studying the chemicals in medicinal plants used in treating malaria. To develop information on traditional medic

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Semedo, Maria Guilherme, João Rui Pita, and Ana Leonor Pereira. "Investigação científica em rede de Portugal para a Europa: o caso da descoberta da cinchonina (1810)." História da Ciência e Ensino: construindo interfaces 27 (January 5, 2024): 407–20. http://dx.doi.org/10.23925/2178-2911.2023v27espp407-420.

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Resumo O isolamento de princípios ativos das plantas vulgarizou-se no século XIX. Cientistas de diversos países contribuíram para este campo da química. De entre as drogas de origem vegetal sujeitas a estudos químicos, destaca-se o caso da casca de quina (proveniente de várias espécies do género Cinchona). Esta casca antimalárica foi extensamente aplicada no tratamento de muitos tipos de febre, como as febres intermitentes. Em Portugal, a quina era de grande interesse, e o governo português procurou alternativas terapêuticas no seu território. Este artigo pretende discutir o isolamento da cinc

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Ellis, Jayne, Prosperity C. Eneh, Kenneth Ssebambulidde, et al. "Case Report: Three's a crowd: a case report examining the diagnostic and pharmacokinetic challenges in HIV-tuberculous meningitis-malaria co-infection." Wellcome Open Research 3 (September 6, 2018): 111. http://dx.doi.org/10.12688/wellcomeopenres.14726.1.

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In 2016, 10.4 million cases of tuberculosis (TB) were reported globally. Malaria also continues to be a global public health threat. Due to marked epidemiological overlap in the global burden of TB and malaria, co-infection does occur. An HIV-infected, 32-year-old male presented with a two-week history of headache with fevers to Mulago National Referral Hospital, Uganda. Five months prior, he was diagnosed with pulmonary TB. He endorsed poor adherence to anti-tuberculous medications. Mycobacterium tuberculosis in CSF was confirmed on Xpert MTB/RIF Ultra. On day 2, he was initiated on dexametha

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Ellis, Jayne, Prosperity C. Eneh, Kenneth Ssebambulidde, et al. "Case Report: Three's a crowd: a case report examining the diagnostic and pharmacokinetic challenges in HIV-tuberculous meningitis-malaria co-infection." Wellcome Open Research 3 (January 15, 2019): 111. http://dx.doi.org/10.12688/wellcomeopenres.14726.2.

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In 2016, 10.4 million cases of tuberculosis (TB) were reported globally. Malaria also continues to be a global public health threat. Due to marked epidemiological overlap in the global burden of TB and malaria, co-infection does occur. An HIV-infected, 32-year-old male presented with a two-week history of headache with fevers to Mulago National Referral Hospital, Uganda. Five months prior, he was diagnosed with pulmonary TB. He endorsed poor adherence to anti-tuberculous medications. Mycobacterium tuberculosis in CSF was confirmed on Xpert MTB/RIF Ultra. On day 2, he was initiated on dexametha

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Pandey, Atul Kumar, Jitender K. Malik, Gyan Singh, and Vinay Siroliya. "Assessment of Anti-arthritis Efficacy of Moringa oleifera: In-silico Molecular Docking." Middle East Research Journal of Pharmaceutical Sciences 4, no. 03 (2024): 42–50. http://dx.doi.org/10.36348/merjps.2024.v04i03.002.

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Background: The severity of rheumatoid arthritis (RA), a chronic, inflammatory, and systemic autoimmune disease, on a patient's joints varies. Age, gender, genetics, and environmental exposure (tobacco use, exposure to air pollution, and occupational exposure) are risk factors. If left untreated, Felty syndrome can develop into a variety of consequences, including rheumatoid vasculitis, persistent joint damage needing arthroplasty, and Felty syndrome necessitating splenectomy. The objectives of treatment for RA are to alleviate discomfort and prevent/slow additional damage because there is no

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Iwata, Momi, Yang Lee, Tetsuo Yamashita, et al. "The structure of the yeast NADH dehydrogenase (Ndi1) reveals overlapping binding sites for water- and lipid-soluble substrates." Proceedings of the National Academy of Sciences 109, no. 38 (2012): 15247–52. http://dx.doi.org/10.1073/pnas.1210059109.

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Bioenergy is efficiently produced in the mitochondria by the respiratory system consisting of complexes I–V. In various organisms, complex I can be replaced by the alternative NADH-quinone oxidoreductase (NDH-2), which catalyzes the transfer of an electron from NADH via FAD to quinone, without proton pumping. The Ndi1 protein from Saccharomyces cerevisiae is a monotopic membrane protein, directed to the matrix. A number of studies have investigated the potential use of Ndi1 as a therapeutic agent against complex I disorders, and the NDH-2 enzymes have emerged as potential therapeutic targets f

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Yves, Eric Denon, Sissinto Yolande, Tokponnon Filémon, et al. "Comparative study of the effectiveness of combination therapies based on atemisinine in Dassa Zounme and Parakou: case of Artemether lumefantrine and Artesunate amodiaquine." International journal of Microbiology and Mycology (IJMM) 2, no. 2 (2014): 1–9. https://doi.org/10.5281/zenodo.8352478.

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The National Malaria Control Program recommended in 1993, the use of Chloroquina (CQ) as first line drug for malaria treatment, and sulfadoxin pyrimethamin as second drug. After years, Benin knows resistance about these antimalarials. Quinina was to treat gravities. In 2004, the strategy of treatment changed. Treatment of malaria cases is based on use of arteminisinia therapeutic combination. The goal of this study is to be sure that these drugs are efficace before general use in the country and in some regions as Dassa Zounmè where the resistance is up (61. 3% for Chloroquina CQ and 45

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Mullen, Saul A., Patrick W. Carney, Annie Roten, et al. "Precision therapy for epilepsy due to KCNT1 mutations." Neurology 90, no. 1 (2017): e67-e72. http://dx.doi.org/10.1212/wnl.0000000000004769.

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ObjectiveTo evaluate quinidine as a precision therapy for severe epilepsy due to gain of function mutations in the potassium channel gene KCNT1.MethodsA single-center, inpatient, order-randomized, blinded, placebo-controlled, crossover trial of oral quinidine included 6 patients with severe autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) due to KCNT1 mutation. Order was block randomized and blinded. Four-day treatment blocks were used with a 2-day washout between. Dose started at 900 mg over 3 divided doses then, in subsequent participants, was reduced to 600 mg, then 300 mg. Prima

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Shahane, Kiran, Madhuri Kshirsagar, Srushti Tambe, et al. "An Updated Review on the Multifaceted Therapeutic Potential of Calendula officinalis L." Pharmaceuticals 16, no. 4 (2023): 611. http://dx.doi.org/10.3390/ph16040611.

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Calendula officinalis Linn. (CO) is a popular medicinal plant from the plant kingdom’s Asteraceae family that has been used for millennia. This plant contains flavonoids, triterpenoids, glycosides, saponins, carotenoids, volatile oil, amino acids, steroids, sterols, and quinines. These chemical constituents confer multifaceted biological effects such as anti-inflammatory, anti-cancer, antihelminthic, antidiabetes, wound healing, hepatoprotective, and antioxidant activities. Additionally, it is employed in cases of certain burns and gastrointestinal, gynecological, ocular, and skin conditions.

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Ferretti, Alessandro, Raffaele Simeoli, Sara Cairoli, et al. "Therapeutic Drug Monitoring of Quinidine in Pediatric Patients with KCNT1 Genetic Variants." Pharmaceutics 14, no. 10 (2022): 2230. http://dx.doi.org/10.3390/pharmaceutics14102230.

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Quinidine (QND) is an old antimalarial drug that was used in the early 20th century as an antiarrhythmic agent. Currently, QND is receiving attention for its use in epilepsy of infancy with migrating focal seizures (EIMFS) due to potassium sodium-activated channel subfamily T member 1 (KCNT1) genetic variants. Here, we report the application of Therapeutic Drug Monitoring (TDM) in pediatric patients carrying KCNT1 genetic variants and orally treated with QND for developmental and epileptic encephalopathies (DEE). We measured plasma levels of QND and its metabolite hydroquinidine (H-QND) by usi

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Feng, Zikai, Monila Nadikudi, Krystel L. Woolley, et al. "Bioactivity Profiles of Cytoprotective Short-Chain Quinones." Molecules 26, no. 5 (2021): 1382. http://dx.doi.org/10.3390/molecules26051382.

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Short-chain quinones (SCQs) have been investigated as potential therapeutic candidates against mitochondrial dysfunction, which was largely thought to be associated with the reversible redox characteristics of their active quinone core. We recently reported a library of SCQs, some of which showed potent cytoprotective activity against the mitochondrial complex I inhibitor rotenone in the human hepatocarcinoma cell line HepG2. To better characterize the cytoprotection of SCQs at a molecular level, a bioactivity profile for 103 SCQs with different compound chemistries was generated that included

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Conejo-Cuevas, Guillermo, Leire Ruiz-Rubio, Virginia Sáez-Martínez, et al. "Spontaneous Gelation of Adhesive Catechol Modified Hyaluronic Acid and Chitosan." Polymers 14, no. 6 (2022): 1209. http://dx.doi.org/10.3390/polym14061209.

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Spontaneously formed hydrogels are attracting increasing interest as injectable or wound dressing materials because they do not require additional reactions or toxic crosslinking reagents. Highly valuable properties such as low viscosity before external application, adequate filmogenic capacity, rapid gelation and tissue adhesion are required in order to use them for those therapeutic applications. In addition, biocompatibility and biodegradability are also mandatory. Accordingly, biopolymers, such as hyaluronic acid (HA) and chitosan (CHI), that have shown great potential for wound healing ap

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Valdes, Roland, Saeed A. Jortani, and Mihai Gheorghiade. "Standards of laboratory practice: cardiac drug monitoring." Clinical Chemistry 44, no. 5 (1998): 1096–109. http://dx.doi.org/10.1093/clinchem/44.5.1096.

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Abstract In this Standard of Laboratory Practice we recommend guidelines for therapeutic monitoring of cardiac drugs. Cardiac drugs are primarily used for treatment of angina, arrhythmias, and congestive heart failure. Digoxin, used in congestive heart failure, is widely prescribed and therapeutically monitored. Monitoring and use of antiarrhythmics such as disopyramide and lidocaine have been steadily declining. Immunoassay techniques are currently the most popular methods for measuring cardiac drugs. Several reasons make measurement of cardiac drugs in serum important: their narrow therapeut

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Singh, Narendra Kumar, and Nabin Khatiwada. "Calotropis Procera Plant Extract: Phytochemical Analysis, Antimicrobial Activity, and Coumarin Compound Identification." KMC Journal 7, no. 1 (2025): 371–88. https://doi.org/10.3126/kmcj.v7i1.75161.

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Phytochemical screening of Calotropis procera (Aakh, Milkweed) leaf and stem extracts was performed using solvents: hexane, benzene, dichloromethane, methanol and distilled water. zAlkaloids, carbohydrates, reducing sugar, tannins, phenolic compounds, gum and mucilage, flavonoids, quinines, and coumarin were all present. At a concentration of 20 g/mL, the methanolic extract of Calotropis procera demonstrated good antibacterial action against two bacteria: the gram-positive Bacillus subtilis and the gram-negative Escherichia coli, as well as fungi, Candida albicans. The therapeutic value of Cal

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Denny, William A. "The Design of Drugs that Target Tumour Hypoxia." Australian Journal of Chemistry 57, no. 9 (2004): 821. http://dx.doi.org/10.1071/ch04051.

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The occurrence of hypoxia in solid tumours is increasingly recognized as a limiting factor in the success of both radiotherapy and chemotherapy treatment, but at the same time offers a tumour-specific phenomenon for the activation of prodrugs. However, the design of clinically useful prodrugs that can be selectively activated in hypoxic cells has proved elusive. Specific reasons (activation by oxygen-insensitive two-electron reductases) have been proposed for the failure of quinone-based prodrugs, but a more general contributing factor may be inappropriate clinical trial design, and the failur

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Uetrecht, Jack P. "Myeloperoxidase as a generator of drug free radicals." Biochemical Society Symposia 61 (November 1, 1995): 163–70. http://dx.doi.org/10.1042/bss0610163.

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Reactive metabolites are believed to be responsible for many types of toxicity, including idiosyncratic drug reactions. Bone marrow is a frequent target of idiosyncratic reactions, and, since these reactions have characteristics that suggest involvement of the immune system, the formation of reactive metabolites by leucocytes could also play a role in the aetiology of idiosyncratic drug reactions. The major oxidation system in neutrophils and monocytes is a combination of NADPH oxidase and myeloperoxidase. This system oxidizes primary arylamines, such as sulphonamides, to reactive metabolites

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Albalawi, Rawan S., Lenah S. Binmahfouz, Rawan H. Hareeri, Rasheed A. Shaik, and Amina M. Bagher. "Parthenolide Phytosomes Attenuated Gentamicin-Induced Nephrotoxicity in Rats via Activation of Sirt-1, Nrf2, OH-1, and NQO1 Axis." Molecules 28, no. 6 (2023): 2741. http://dx.doi.org/10.3390/molecules28062741.

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Nephrotoxicity is a serious complication that limits the clinical use of gentamicin (GEN). Parthenolide (PTL) is a sesquiterpene lactone derived from feverfew with various therapeutic benefits. However, PTL possesses low oral bioavailability. This study aimed to evaluate the therapeutic protective effects of PTL-phytosomes against GEN-induced nephrotoxicity in rats. The PTL was prepared as phytosomes to improve the pharmacological properties with a particle size of 407.4 nm, and surface morphology showed oval particles with multiple edges. Rats were divided into six groups: control, nano-formu

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Wu, An-Guo, Yuan-Yuan Yong, Yi-Ru Pan, et al. "Targeting Nrf2-Mediated Oxidative Stress Response in Traumatic Brain Injury: Therapeutic Perspectives of Phytochemicals." Oxidative Medicine and Cellular Longevity 2022 (April 4, 2022): 1–24. http://dx.doi.org/10.1155/2022/1015791.

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Traumatic brain injury (TBI), known as mechanical damage to the brain, impairs the normal function of the brain seriously. Its clinical symptoms manifest as behavioral impairment, cognitive decline, communication difficulties, etc. The pathophysiological mechanisms of TBI are complex and involve inflammatory response, oxidative stress, mitochondrial dysfunction, blood-brain barrier (BBB) disruption, and so on. Among them, oxidative stress, one of the important mechanisms, occurs at the beginning and accompanies the whole process of TBI. Most importantly, excessive oxidative stress causes BBB d

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Muni Raja Lakshmi, K., M. Kiran, and K. Sai Prasanna. "A Review on Natural Plants for Phytochemical Constituents and Pharmacological Activities." Journal of Drug Delivery and Therapeutics 11, no. 2 (2021): 232–36. http://dx.doi.org/10.22270/jddt.v11i2.4593.

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The present review aims for the study of phytoconstituents and pharmacological activities of some natural plants. The traditional medicinal plants have been found to acquire therapeutic activities significantly antimicrobial, anti-inflammatory antibacterial, anti-fungal, antioxidant properties etc. The plant-derived constituents are majorly for the aliments of used skin disease diabetes, bronchitis, asthma, arthritis, dry cough, ulcer and fever. The antimicrobial activity of the following plants like Justicia adathoda, Lantana Camara, Acacia leucophloea, Holoptelea integrifolia, Calotropis Pro

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Djidénou, AHOTON, Fidèle ASSOGBA Mahoudo, Dominique CHODATON ZINSOU Marthe, Chikani YAYI LADEKAN Eléonore, MOUDACHIROU Mansourou, and Djimon GBENOU Joachim. "Phenolic compounds' dosage and antioxidant activities of ethanolic and aqueous extracts of Cassytha filiformis' Linne (Lauraceae) lianas saprophyte of Melaleuca quinquenervia (Cav.) ST Blake Myrtaceae." Chemistry Research Journal 6, no. 2 (2021): 94–104. https://doi.org/10.5281/zenodo.11636155.

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<strong>Abstract </strong><em>Cassytha filiformis</em> L., plant with several therapeutic virtues (purgative, hemorrhoid, ulcer, gonorrhea ..), is also used in the treatment of liver diseases. Hepatic diseases are diseases related to oxidative stress. The treatment of liver diseases requires therefore the intake of antioxidant substances. The aim of this work is to prove the antioxidant activity’s of <em>Cassytha filiformis’</em> ethanolic and aqueous extracts. The ethanolic and aqueous extracts were prepared according to the traditional method and use of <em>Cassytha filiformis</e

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Haji, Naemah, Masoma Faizi, Panayiotis A. Koutentis, Michael P. Carty, and Fawaz Aldabbagh. "Heterocyclic Iminoquinones and Quinones from the National Cancer Institute (NCI, USA) COMPARE Analysis." Molecules 28, no. 13 (2023): 5202. http://dx.doi.org/10.3390/molecules28135202.

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This review uses the National Cancer Institute (NCI) COMPARE program to establish an extensive list of heterocyclic iminoquinones and quinones with similarities in differential growth inhibition patterns across the 60-cell line panel of the NCI Developmental Therapeutics Program (DTP). Many natural products and synthetic analogues are revealed as potential NAD(P)H:quinone oxidoreductase 1 (NQO1) substrates, through correlations to dipyridoimidazo[5,4-f]benzimidazoleiminoquinone (DPIQ), and as potential thioredoxin reductase (TrxR) inhibitors, through correlations to benzo[1,2,4]triazin-7-ones

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Casertano, Marcello, Massimo Genovese, Alice Santi, et al. "Evidence of Insulin-Sensitizing and Mimetic Activity of the Sesquiterpene Quinone Avarone, a Protein Tyrosine Phosphatase 1B and Aldose Reductase Dual Targeting Agent from the Marine Sponge Dysidea avara." Pharmaceutics 15, no. 2 (2023): 528. http://dx.doi.org/10.3390/pharmaceutics15020528.

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Type 2 diabetes mellitus (T2DM) is a complex disease characterized by impaired glucose homeostasis and serious long-term complications. First-line therapeutic options for T2DM treatment are monodrug therapies, often replaced by multidrug therapies to ensure that non-responding patients maintain target glycemia levels. The use of multitarget drugs instead of mono- or multidrug therapies has been emerging as a main strategy to treat multifactorial diseases, including T2DM. Therefore, modern drug discovery in its early stages aims to identify potential modulators for multiple targets; for this pu

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Yehya, Amani, Alissar Monzer, Kevork Wakimian, et al. "Abstract 5792: The novel therapeutic diiminoquinone exhibits anticancer effects on human prostate cancer cells in 2D and 3D in vitro models." Cancer Research 83, no. 7_Supplement (2023): 5792. http://dx.doi.org/10.1158/1538-7445.am2023-5792.

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Abstract Aim: To investigate the anticancer potential of the novel quinone DIQ on prostate cancer (PCa) cells in two-dimensional (2D) and three-dimensional (3D) in vitro. Methods: The anti-proliferative effect of DIQ on PC3 and DU145 PCa cell lines was determined in vitro by using 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and trypan blue exclusion assays. In addition, the potency of DIQ was tested on the formation and size of PCa cell-derived prostatospheres and organoids grown in a specialized 3D-culture system. Also, 3D organoids were established from fresh tissue sa

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Vanessa, Tobert, Allen James, and Edmond Evan. "THUR 264 Multimodal intervention to improve lumbar puncture." Journal of Neurology, Neurosurgery & Psychiatry 89, no. 10 (2018): A38.2—A38. http://dx.doi.org/10.1136/jnnp-2018-abn.133.

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IntroductionLumbar puncture (LP) is a routine procedure performed for diagnostic and therapeutic indications for more than 120 years.1 For as long, post-dural puncture headache (PDPH) has been a complication that can be persistent and severe.2 Finer gauge needles and ‘atraumatic’ needle designs3 significantly reduce the incidence of PDPH.4–6MethodsA multimodal intervention consisting of teaching session on atraumatic needle usage, simulation training with 25G Sprotte needles, and electronic LP proforma was introduced in October 2017.Records for all patients having LP in the Neurology day-case

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Marathe, P., M. Thao, and I. Benjamin. "ID: 11: REDOX PROFILING OF CARVEDILOL AND PROPRANOLOL IN A HEART MODEL." Journal of Investigative Medicine 64, no. 4 (2016): 923.1–923. http://dx.doi.org/10.1136/jim-2016-000120.25.

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IntroductionClinical trials have shown that carvedilol is highly effective against heart failure (HF). Carvedilol, unlike propranolol, has direct antioxidant effects and is capable of mitigating oxidative stress in HF patients. Moreover, it has been suggested that carvedilol has an indirect antioxidant mechanism that could involve the initial production of non-lethal levels of oxidative stress leading to the regulation of an uncharacterized antioxidant response that later counters oxidative stress.HypothesisWe hypothesized that carvedilol's indirect antioxidant mechanism may involve the nuclea

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Manneck, David, Gisela Manz, Hannah-Sophie Braun, Julia Rosendahl, and Friederike Stumpff. "The TRPA1 Agonist Cinnamaldehyde Induces the Secretion of HCO3− by the Porcine Colon." International Journal of Molecular Sciences 22, no. 10 (2021): 5198. http://dx.doi.org/10.3390/ijms22105198.

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A therapeutic potential of the TRPA1 channel agonist cinnamaldehyde for use in inflammatory bowel disease is emerging, but the mechanisms are unclear. Semi-quantitative qPCR of various parts of the porcine gastrointestinal tract showed that mRNA for TRPA1 was highest in the colonic mucosa. In Ussing chambers, 1 mmol·L−1 cinnamaldehyde induced increases in short circuit current (ΔIsc) and conductance (ΔGt) across the colon that were higher than those across the jejunum or after 1 mmol·L−1 thymol. Lidocaine, amiloride or bumetanide did not change the response. The application of 1 mmol·L−1 quini

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Dunigan, Katelyn, Qian Li, Rui Li, Morgan L. Locy, Stephanie Wall, and Trent E. Tipple. "The thioredoxin reductase inhibitor auranofin induces heme oxygenase-1 in lung epithelial cells via Nrf2-dependent mechanisms." American Journal of Physiology-Lung Cellular and Molecular Physiology 315, no. 4 (2018): L545—L552. http://dx.doi.org/10.1152/ajplung.00214.2018.

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Thioredoxin reductase-1 (TXNRD1) inhibition effectively activates nuclear factor (erythroid-derived 2)-like 2 (Nrf2) responses and attenuates lung injury in acute respiratory distress syndrome (ARDS) and bronchopulmonary dysplasia (BPD) models. Upon TXNRD1 inhibition, heme oxygenase-1 (HO-1) is disproportionally increased compared with Nrf2 target NADPH quinone oxidoreductase-1 (Nqo1). HO-1 has been investigated as a potential therapeutic target in both ARDS and BPD. TXNRD1 is predominantly expressed in airway epithelial cells; however, the mechanism of HO-1 induction by TXNRD1 inhibitors is u

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Al-Fatlawi, Atheer Abbas Yaseen, and Majida Malik Meteab Al-Shammari. "Rice bran phytic acid protects against methotrexate -induced oxidative stress and acute liver injury in rats." Kufa Journal For Veterinary Medical Sciences 8, no. 1 (2017): 249–60. http://dx.doi.org/10.36326/kjvs/2017/v8i14301.

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Methotrexate is an effective and extensively used chemotherapeutic agent to treat range of malignancies, but its therapeutic use is limited because of dose dependent hepatotoxicity. Several published reports advocate that supplementation with antioxidant can influence methotrexate induced acute liver injury. Twenty four adult male rats (aged 56 days and weighted 138±8.8g) were randomly assigned into four equal groups (control and three treated groups), first group as control group given normal saline, a second single injection 20mg /kg B.W. i.p. of methotrexate, third group given15mg/kg B.W. o

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Al-Fatlawi, Atheer Abbas Yaseen, and Majida Malik Meteab Al-Shammari. "Rice bran phytic acid protects against methotrexate -induced oxidative stress and acute liver injury in rats." Kufa Journal For Veterinary Medical Sciences 8, no. 1 (2017): 249–60. http://dx.doi.org/10.36326/kjvs/2017/v8i14301.

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Methotrexate is an effective and extensively used chemotherapeutic agent to treat range of malignancies, but its therapeutic use is limited because of dose dependent hepatotoxicity. Several published reports advocate that supplementation with antioxidant can influence methotrexate induced acute liver injury. Twenty four adult male rats (aged 56 days and weighted 138±8.8g) were randomly assigned into four equal groups (control and three treated groups), first group as control group given normal saline, a second single injection 20mg /kg B.W. i.p. of methotrexate, third group given15mg/kg B.W. o

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