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1
Xiang, Hong. "Effects of myo-inositol and, or triiodothyronine (T₃) treatment on cardiac dysfunction and elevated myocardial lipid levels in STZ-diabetic rats." Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/26675.
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A number of experimental studies have implied a link between diabetes-induced lipid accumulation in the myocardium and the development of cardiomyopathy. Since diabetics excrete large amounts of myo-inositol which is a lipotropic agent, this study was undertaken to investigate the effects of myo-inositol on the elevated myocardial lipid levels and the depressed cardiac performance of diabetic rats. Diabetes was induced in female Wistar rats (190-215 g) with streptozotocin (STZ) (55 mg/kg, i.v.). Three days after diabetes induction, myo-inositol was administered in the drinking water (2.5 g/kg/day) for a 8 week period. Untreated diabetics exhibited a loss of body weight, hyperglycemia, hypoinsulinemia and hypothyroidism. These effects were not altered after myo-inositol treatment. STZ-diabetes also produced a significant elevation of plasma and myocardial triacylglycerol, cholesterol and phospholipid. Myo-inositol treatment decreased these lipid levels. In addition, hearts from diabetic animals had a decreased ability to develop left ventricular developed pressure (LVDP) and both the rate of pressure rise (+dP/dt) and the rate of pressure decline (-dP/dt) were also reduced. Hearts from myo-inositol-treated diabetic animals showed a partial but definite improvement of cardiac function.
As diabetes-induced hypothyroidism was not altered after myo-inositol supplementation, a combination treatment of both myo-inositol (2.5 g/kg/day, p.o. daily) and T₃ (30 ug/kg/day, s.c. daily) was then undertaken to determine whether heart function of diabetic rats could be further improved. STZ-diabetic rats were characterized by a loss of body weight, hyperglycemia and hypoinsulinemia; none of which were altered by either T₃ or myo-inositol plusT₃ treatment. T₃ treatment normalized the thyroid state of diabetic animals as shown by Tahiliani and McNeill (1984). However, plasma and myocardial triacylglycerol, cholesterol and phospholipid levels of diabetic rats either remained elevated or were further increased with T₃ or myo-inositol plus T₃ treatment. In addition, T₃ treatment alone did not prevent cardiac dysfunction in diabetic rats. There was, however, some improvement in heart function in the groups treated with both myo-inositol and T₃, but the improvement was not as pronounced as with myo-inositol treatment alone.<br>Pharmaceutical Sciences, Faculty of<br>Graduate
2
Ramez-Baydoun, Lubna Lulu. "Novel chelating agents for therapeutic use." Thesis, King's College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406043.
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Marnewick, Jeanine Lucasta. "Cancer modulating properties of unique South African herbal teas (rooibos and honeybush) in short term in vitro and in vivo carcinogenesis assays." Thesis, Stellenbosch : Stellenbosch University, 2004. http://hdl.handle.net/10019.1/21888.
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Dissertation (PhD)--University of Stellenbosch, 2004.<br>ENGLISH ABSTRACT: This thesis provides the first scientific evidence on the cancer modulating properties of
two unique South African herbal teas, rooibos (Aspalathus Iinearis) and honeybush
(Cyclopia intermedia) utilizing in vitro as well as in vivo carcinogenesis assays by:
• Demonstrating the in vitro antimutagenic activity of aqueous extracts of the
herbal teas against the metabolic activated mutagens, 2-acetylaminofluorene (2-
AAF) and the mycotoxin, aflatoxin B1 (AFB,) as well as, to a certain extent,
against the direct acting mutagen, hydrogen peroxide, utilizing the Salmonella
typhimurium mutagenicity assay.
• Increasing the activity of hepatic drug metabolizing enzymes, glutathione Stransferase
alpha and UPD-glucuronosyl transferase, and reduced the oxidative
stress by stabilizing the level of reduced glutathione (GSH) resulting in an
increased hepatic reduced to oxidized glutathione ratio (GSG:GSSG). No toxic
effects were noticed in rats consuming the herbal teas for 10 weeks as their sole
source of drinking fluid.
• Demonstrating the ex vivo modulation of 2-AAF- and AFB1-induced mutagenesis
by sub- cellular hepatic fractions of rats consuming the herbal teas in the
Salmonella mutagenicity assay. Hepatic cytosolic fractions protected against
mutagenesis of both mutagens, while the microsomal fractions exhibited a
reduced capacity to metabolize AFB1 to its active mutagenic metabolite.
• Providing evidence for the in vivo modulation of tumour promotion using the liver
as well as the two-stage skin carcinogenesis animal models. The unprocessed
herbal teas arrested proliferation of the placental form of glutathione-Stransferase
(GSTP+) altered cells as well as reduced the total number of enzyme
altered foci in the liver of rats. Topical application of polyphenolic fractions of the
various herbal teas prior to 12-0-tetra-decanoylphorbol-13-acetate (TPA) tumour
promotion, reduced tumour formation in mouse skin initiated with 7,12-dimethylbenz[
ajanthracene (DMBA). The protective effect was illustrated by a decreased
tumour incidence, a reduction in tumour volume as well as a delayed onset of tumour development. The f1avanol/proanthocyanidin content of the fractions
could playa major role in the protection against skin tumour promotion.
• Proposing possible mechanisms whereby rooibos and honeybush herbal teas
could exert their cancer modulating properties with respect to in vitro and ex vivo
antimutagenicity, in vivo oxidative status and reduced tumour promotion.
• Providing evidence that the herbal teas mimic the cancer modulating properties
of green and black teas although differences exist, presumably due to differences
in the polyphenolic constituents.
• Suggesting that rooibos and honeybush herbal teas may play an important role
as chemopreventive agents in the modulation of cancer.<br>AFRIKAANSE OPSOMMING: Hierdie tesis bevat die eerste ondersoek na die effek van waterige en polifenoliese
ekstrakte van rooibos (Aspalathus Iinearis) en heuningbos (Cyclopia intermedia) op
verskeie aspekte van kankerontwikkeling. Die twee kruietees is uniek aan Suid-Afrika
en kan 'n belangrike rol speel in die voorkoming van kanker. Verskillende in vitro so wei
as in vivo studies het die volgende getoon:
• Antimutageniese aktiwiteite teen die metabolies-geaktiveerde mutagene, 2-
asetielaminofluoreen (2-AAF) en die mikotoksien, aflatoksien B1 (AFB1) in die
Salmonella fyphimurium mutagenisiteitstoets. 'n Beperkte mate van beskerming
is ook verleen teen die oksidatiewe mutageen, waterstofperoksied, sonder
metaboliese aktivering.
• Verhoogde aktiwiteite van die fase II ensieme, glutatioon S-tranferase alfa en
UDP-glukuronidase, wat liggaamsvreemde verbindings metaboliseer. Die
kruietees verlaag die oksidasietoestand soos weerspieel word deur 'n toename
van gereduseerde glutatioon tot die geoksideerde vorm in die lewer van rotte wat
10 weke hierdie kruietees gedrink he!. Die kruietees het geen toksiese uitwerking
op die rotte gehad nie.
• Antimutageniese aktiwiteite van subselluiE~re fraksies van die lewer teenoor 2-
AAF en AFB1 in die Salmonella toets. Die sitosolfraksie van die rotlewer bied
beskerming teen die ge"induseerde mutagenese van beide mutagene, terwyl die
mikrosomale fraksie ook die metaboliese aktivering van AFB1 na die aktiewe
mutageniese metaboliet verminder.
• In vivo modulering van kankerpromosie met behulp van bekende rotlewer en
muisvel kankerontwikkelingsmodelle. In die lewermodel het die
ongeprosesseerde kruietees beide die ontwikkeling en getal van GSTP+ fokusse
onderskeidelik vertraag en verminder. In die geval van die velkankermodel het
aanwending van polifenoliese fraksies van die kruietees beskerming gebied teen
die ontwikkeling van velkankers by muise. Die aantal en grootte van die tumors
het afgeneem terwyl die verskyning daarvan ook vertraag is. • Verskeie meganismes waardeur rooibos- en heuningboslee moonllik kanker kan
moduleer word voorgeslel. Verskille in die polifenoliese sameslelling asook hul
onderskeie konsenlrasies kan 'n belangrike rol speel in die kankerveranderende
effekle van die lees.
• Oal gereelde inname van rooibos- en/of heuningboslee moonllik 'n belangrike rol
kan speel in die voorkoming van dieel- en omgewings-geYnduseerde kankers.
4
Cheng, Ka-wing, and 鄭家榮. "Preventive potential and mechanism of dietary phenolics on the formation of mutagenic heterocyclic amines." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B4284177X.
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The Best PhD Thesis in the Faculties of Dentistry, Engineering, Medicine and Science (University of Hong Kong), Li Ka Shing Prize,2008-2009<br>published_or_final_version<br>Biological Sciences<br>Doctoral<br>Doctor of Philosophy
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Stapleton, Graham Neil. "A study of the effects of sucralfate in the bile duct litigated pig peptic ulcer model with particular reference to the effects on the physico-chemical properties of gastric mucus and including comparisons with famotidine and misoprostol." Master's thesis, University of Cape Town, 1992. http://hdl.handle.net/11427/25727.
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Sucralfate is a drug that effectively heals duodenal, gastric and oesophageal ulcers. It is not absorbed systemically and it has been shown to act locally by coating the ulcer base. However when it was also shown to prevent stress ulcers and ethanolinduced gastric mucosa! lesions, it seemed likely that it acted in some way to improve the effectiveness of the gastric mucosa! barrier. Some investigators suggested that it did so by stimulating local prostaglandin release. The Slomiany group, on the basis of in vitro work on the effects of Sucralfate on pig gastric mucus, claimed that Sucralfate acted by altering the physico-chemical properties of mucus to increase the viscosity and retard the back diffusion of H+ ions. The work described in this dissertation set out to verify, in vivo, these claimed effects on mucus, using an experimental porcine model of peptic ulceration, the bile duct ligated pig. In addition, the effects of Sucralfate were compared with those of Famotidine and Misoprostol, and changes in mucous prostaglandins, gastric juice pepsin and gastric flora were sought. By way of introduction, the known and postulated actions of Sucralfate, current understanding of gastric mucus physiology and pathogenesis of peptic ulceration, have been reviewed, as have experimental animal models of peptic ulceration, in order to justify using the bile duct ligated pig model.
6
Betz, Jennifer. "The Use of Improvisation in Therapeutic Practices." Kent State University Honors College / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1557312650223249.
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Parsons, Ann Bernardene. "Designing a resource guide for horticultural therapy programs at botanical gardens and arboreta." Thesis, Virginia Polytechnic Institute and State University, 1985. http://hdl.handle.net/10919/104531.
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余詩德 and Sze-tak Yu. "Effects of Chinese green tea and tea catechins on lipolysis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31969677.
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Zhang, Jingjing, and 张晶晶. "The anti-cancer properties of cyclometalated gold(III) complexes and organogold(III) supramolecular polymers." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/208171.
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Prompted by the successful clinical application of cisplatin in cancer therapy, worldwide efforts have been devoted to develop new metal-based drugs for anticancer treatment. Gold(III) complexes at first received attention as anti-cancer drug candidates because of their square-planar geometry which resembles that of platinum(II) complexes. Subsequent studies revealed that various gold(III) complexes displayed promising anti-cancer activities with different biological mechanisms. Although some achievements have been obtained in the development of anti-cancer gold(III) complexes, challenges including the improvement of bioavailability, stability and selectivity, elucidation of the action mechanisms, and the development of novel delivery approaches of gold(III) complexes to reduce systematic toxicity, remain to be exploited.
A panel of anti-cancer complexes [AuIII(R-C^N)(L)]n+ (wherein HC^N is 2-phenylpyridine, L is biguanide or biuret) have been identified and described in Chapter 3. Biguanide or biuret have been employed to improve the solubility of the complexes in aqueous solutions. Meanwhile, the lipophilicity could readily be adjusted by varying the R group to obtain a balance between lipophilicity and aqueous solubility. Among the synthesized complexes, the cationic complexes, [AuIII(butyl-C^N)biguanide]Cl (3.1) and [AuIII(C^N)biguanide]Cl (3.2) are soluble in aqueous solutions with solubility over 5 mg/mL. Besides, introduction of butyl groups to 3.1 and [AuIII(butyl-C^N)biuret] (3.3) resulted in higher cellular uptake of gold, which might enhance their cytotoxic activities (IC50 values: 1.5–17 μM) compared with 3.2 and [AuIII(C^N)biuret] (3.4) (IC50 values: 9.4–47.3 μM). Moreover, 3.1 was also found to induce cell cycle arrest in S-phase and endoplasmic reticulum (ER) damage in human cervical epithelial carcinoma (HeLa) cells, and display significant anti-angiogenic activity at its sub-cytotoxic concentrations.
In Chapter 4, a series of gold(III) complexes with dithiocarbamate and 2-phenylpyridine ligands to target deubiquitinases (DUBs), have been designed. These complexes achieved significant inhibition on purified DUBs. Notably, [AuIII(2-(4-nbutylphenyl) pyridyl)(diethyldithiocarbamate)]PF6 (4.1) inhibited both the purified (IC50 values: 46–223 nM) and cell-based DUBs activities with high efficiency. Its interaction with DUB UCHL1 and peptides which are present in several types of DUBs and contain active cysteine residue were confirmed by mass spectrometric analysis. All complexes displayed significant cytotoxicities, and those containing diethyldithiocarbamate ligand displayed specific cytotoxicity on breast cancer cells. Accumulation of a tumor suppressor p53, cell-cycle arrest, and apoptotic cell death were induced in breast cancer cells by 4.1. Besides, 4.1 also showed anti-angiogenic effects. These biological activities might be related with DUBs inhibition.
In Chapter 5, a cytotoxic complex [AuIII(C^N^C)(4-dpt)](CF3SO3) (5.1, HC^N^CH = 2,6-diphenylpyridine; 4-dpt = 2,4-diamino-6-(4-pyridyl)-1,3,5-triazine) has been designed to self-assemble into supramolecular polymers (5.1-SP) in acetonitrile. In physiologically relevant solutions, 5.1-SP displayed a sustained-release property of the anti-angiogenic ligand 4-dpt, and in the presence of glutathione (GSH), [AuIII(C^N^C)-GSH] adduct(s) were also gradually released. The supramolecular polymers 5.1-SP also showed selective cytotoxicity toward cancerous cells, and could act as drug-carriers of other cytotoxic agents to achieve sustained-release behavior.<br>published_or_final_version<br>Chemistry<br>Doctoral<br>Doctor of Philosophy
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Roberts, Jacintha. "Studies on bisphosphonate elution from orthopaedic implants." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112582.
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In a 6-week rat model it was demonstrated that a small dose of peri-implant zoledronic acid (ZA) increased local bone formation 3-fold compared with controls. Ancillary in vitro studies using 14C-labeled ZA implant doses demonstrated biphasic elution profiles for implants coated with hydroxyapatite; complete ZA release occurred within one to three weeks in serum compared with only 60% ZA release after 12 weeks in water. Implants without hydroxyapatite coating showed more burst-type release profiles and full ZA elution within 24 hours of hydration in serum or water. Canine studies at 6 weeks using implants with 14C-labeled ZA showed that the compound remained localized, with the greatest ZA concentration immediately adjacent to the implant. Although there was evidence of skeletal ZA distribution via diffusion into the circulation, the levels were two orders of magnitude less than at the implant site.
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Kilinkissa, Ornella Edlyne Youdaga. "Physical chemical properties of selected pharmaceutical co-crystals." Thesis, Cape Peninsula University of Technology, 2014. http://hdl.handle.net/20.500.11838/731.
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Thesis submitted in fulfilment of the requirements for the degree
Magister Technologiae: Chemistry
in the Faculty of Applied Sciences at the
CAPE PENINSULA UNIVERSITY OF TECHNOLOGY
2014<br>The solid state modification of a given active pharmaceutical ingredient is a desired way to
alter its physicochemical properties, such as solubility or bioavailability. The solubilitymelting
point relationship of the ensuing co-crystal or salt is not fully understood.
In this thesis, a series of model co-crystals and pharmaceutical co-crystals and salts of
baclofen were investigated. The model co-crystals were prepared from 4,4’-bipyridine (BIPY)
and 1,2-bis(4-pyridyl)ethane (ETBIPY) used as host compounds which were combined with a
series of carboxylic acids as co-formers, such as p-toluic acid (PTA), rac-phenylbutyric acid
(racPBA), racemic and S-phenylsuccinic acid (racPSA and S-PSA, respectively). In the
second part, six new multicomponent crystals of baclofen (BAC, (RS) 4-amino-3-(4-
chlorophenyl)-butanoic acid), were prepared with mono- and dicarboxylic acids: two
pharmaceutical co-crystals obtained with benzoic acid (BAC•BA) and p-toluic acid
(BAC•PTA) and four pharmaceutical salts with 1-hydroxy-2-naphthoic acid, (BAC+)(HNA-),
oxalic acid, 2(BAC+)(OA2-), maleic acid, (BAC+)(MA-) and p-toluene sulfonic acid,
(BAC+)(PTSA-)•IPA. The compounds prepared were analysed by single crystal and powder
X-ray diffractometry, differential scanning calorimetry and their solubility was measured in
water and ethanol.
From the analysis of the model co-crystals it was concluded that their aqueous solubility is
inversely related to the melting point values and this can be explained by packing features.
Also, the introduction of a chiral building block, compared to its racemic counterpart, is a
valuable way to limit the formation of the intermolecular interactions in the new
multicomponent crystal and thus decrease the efficiency of the packing which eventually
leads to lower melting points and better solubility.
The analysis of the baclofen crystals suggests that a strong, robust and predictable hydrogen
bonding network with a combination of molecular building blocks which show acceptable
molecular flexibility is a good recipe for successful co-crystal design.
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Zhang, Xiao, and 張瀟. "The effects of l-tetrahydropalmatine and rhynchophylline, alkaloids derived from herbal medicines, on cellular and molecular neurotoxicityof cocaine in PC12 cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43572248.
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Wang, Ning Michael, and 王宁. "The preventive and curative potential of berberine and coptis on humanhepatocellular carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48079637.
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Hepatocellular carcinoma (HCC) is the primary cancer of liver. It is the fifth common malignant tumor in men while seventh common in women. Aetiology of HCC is complex; however, it is now believed that sustained chronic liver injury and fibrosis are critically involved in the development of HCC. Prevention and treatment of HCC is far from desirable and prognosis remains poor. Coptis is a Chinese herbal Medicine which has been used for more than thousands years for clearing heats, dampness and toxics. Recently, studies from our group reported the hepatoprotective effect of Coptis and its major active component, berberine, on acute liver injury and berberine was extensively studied for their anti-tumor effect. However, there’s no comprehensive investigation focusing on the preventive and curative potential of berberine on HCC. Hence, here we hypothesized Coptis and berberine exhibits both preventive and curative effects on HCC. The prevention of HCC by berberine and Coptis may rely on their effects on chronic liver damage and fibrosis, and the curative action may depend on their actions on the angiogenesis, tumor growth and invasion of HCC. Both in vitro cell models and in vivo animal system were used in our study and some molecular events were investigated. We found that berberine and Coptis could significantly attenuate the chronic liver injury and fibrosis by restoring the anti-oxidative enzyme SOD activity in CCl4-, bile duct ligation- and alcohol-induced liver injury and fibrosis model. Recovery of SOD activity prevents the hepatocytes from apoptosis by inhibiting the oxidative stress-induced Erk1/2 signaling activation. The prevention of berberine and Coptis on chronic liver injury and fibrosis may contribute to its preventive effect against HCC. Then we found that berberine (as representative to Coptis) could suppress the angiogenesis of HCC, in which berberine does not directly act on the blood vessel formation, but suppress the expression and secretion of pro-angiogenic factors VEGF in HCC cells, and Id-1 inhibition by berberine plays a central role in the suppression of HIF-1α/VEGF and NF-κB pathways. We also found that berberine could induce both apoptotic and autophagic cell death in HCC, and the mitochondria related-caspases activation confers the apoptosis while mTOR inhibition initiates autophagy in berberine treated- cells. We found that berberine could suppress the migration and invasion of HCC cells as well, and Rho-GTPases/ROCK signaling is the particular target in berberine’s anti-invasive action. Finally, to dig out some molecular events involved in berberine’s action on HCC, we studied critically the mechanism underlying berberine’s inhibition on Cyclin D1 in HCC. We found berberine may promote the IKKα-induced Cyclin D1 phosphorylation at T286, and this may initiate the ubiquitination-dependent proteasomal degradation of Cyclin D1 in berberine-treated HCC cells and contribute to berberine’s anti-HCC action. Critical clinical trials and OMICS techniques were planned to further our comprehensive study on Coptis and berberine’s effects on HCC. In all, we found that berberine targets on different stages and molecules and exerts preventive and curative potential against HCC. Our study sheds light on the clinical application of berberine in HCC treatment.<br>published_or_final_version<br>Chinese Medicine<br>Doctoral<br>Doctor of Philosophy
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Chan, Chung-ling Pansy, and 陳鍾靈. "The long-term effects of yoga and aerobic exercise on cognitive function and clinical symptoms in early psychosis : a follow-up randomized control trial." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206585.
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Background: A study of the impact of yoga and aerobic exercise and psychosis was conducted in 2012 by Lin et al., from The University of Hong Kong. The study indicated significant improvement in the aspects of physical fitness, cognitive functions, psychosocial and emotional functioning in patients with psychosis after a 12-week yoga or aerobic intervention program. Long-term effect of exercise intervention, however, had yet been determined. The aim of the present study was to evaluate the long-term effects of yoga and aerobic exercise on cognitive functioning and clinical symptoms in early psychosis. Patients who originally participated in Lin et al.’s 2012 study were recruited and re-assessed in this current 18-month follow-up study.
Methods: Two intervention groups (yoga and aerobic exercise group) and one control group (wait-list control group) of a total 57 subjects from the initial study were recruited in this follow-up study. Cognitive functioning and clinical symptoms were assessed at three time points (T1:Baseline, T2:12-week, T3:18-month).
Results: No significant changes or significant deterioration were found in cognitive functioning, clinical symptoms and depression between T2 (12-week) and T3 (18-month) in both intervention groups (yoga and aerobic group). Significant improvement of clinical symptoms was observed in wait-list control group at T3.
Conclusions: Although there is no significant finding in this current study, it is still recommended that further study on the relationship between physical exercise intervention and psychosis should carried out in order to explore other adjunct, and especially low cost, treatment to antipsychotics in treating people with psychosis.<br>published_or_final_version<br>Psychological Medicine<br>Master<br>Master of Psychological Medicine
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Hall, Clifford Michael. "Relative efficacy of hydrocortisone and methylprednisolone in acute severe asthma." Thesis, University of Cape Town, 1993. http://hdl.handle.net/11427/25562.
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Razmovski-Naumovski, Valentina. "Characterisation of Gynostemma Pentaphyllum Saponins Affecting Cholesterol Homeostasis." Thesis, The University of Sydney, 2004. https://hdl.handle.net/2123/29787.
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G. pentaphyllum (Thun.) Makino (Cucurbitaceae) is a perennial climbing herb,
mainly found in southern tropical areas of Asia. Traditional use of the herb
dates back 500 years and includes treatment for chronic tracheitis, bronchitis,
infectious hepatitis, pyelitis and gastroenteritis. Its numerous medicinal
applications include anti-inflammatory, anti-toxic, anti-tussive and
expectoratory actions. The plant is not endemic to Australia and, as far as the
author knows, has never been cultivated in this region. Therefore, cultivation
of G. pentaphyllum was undertaken in Sydney, Australia in order assess its
growth in a new environment and to provide local material for further chemical
and biological assessment (Chapter 2). It was observed that G. pentaphyllum
adapted successfully to the Sydney soil, light and water conditions and the
yields provided ample supply of material for extraction purposes.
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Alder, Louise B. A. "Immunoregulatory properties of polyclonal immunoglobulin for therapeutic use." Thesis, University of Newcastle Upon Tyne, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361937.
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Lloyd, Jonathan. "The therapeutic use of metaphor : a heuristic study." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/the-therapeutic-use-of-metaphor-a-heuristic-study(a020949f-3653-4812-af1d-ccbf49e53f98).html.
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Background: This research was designed to explore the experience and understanding of counsellors' and psychotherapists' engagement with metaphors in the therapeutic process. The aim is to reflect on the experience of therapists involved in therapeutic metaphors from differing perspectives. Methodology: In a heuristic study a group of seven therapists (counsellors and psychotherapists) shared their use of metaphors in their therapy practice. Data were collected through an informal conversational interview that supported the participants to share their experiences in a natural dialogue. Findings: The experience of using metaphor in therapy appears to involve a multi-faceted web of generation, construction and development between the therapist and client. Various levels of depth of metaphor in therapy were identified along with links to transferential and cultural issues. Metaphors of hope also appear to be potentially important. Discussion: The findings suggest that the use of metaphors in therapy is pervasive. Metaphors that reflect an empathic connection and encounter between therapist and client were identified. Dualistic thinking around the origination of metaphors in therapy is challenged and the concept of co-creation and the mutual development of moving metaphors is discussed. Environmental and cultural influences are considered alongside transferential aspects. Conclusion: It appears that the use of metaphor in therapy is pervasive and offers an opportunity for therapeutic change. The consideration of the construction of metaphors and their mutual development may be useful for therapists to consider. This research highlights the need for more investigation with regard to client perspectives, the environmental impacts on metaphors in therapy and who the therapist and client stand for metaphorically for each other.
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Ngwa, Conelius. "Use of peptide nucleic acids as therapeutic agents." Thesis, Aston University, 2014. http://publications.aston.ac.uk/24385/.
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Carvalho, George. "Studies on the inotropic effect of insulin and glucose : a new diet for the ischemic heart?" Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101840.
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The present project investigated the effect of glucose, high dose insulin and normoglycemia (GIN) therapy in patients undergoing coronary revascularization surgery. A reduction in myocardial injury as measured by cardiac troponin I was the primary end point. Cardiac function based on hemodynamics and vasoactive drug requirements as well as clinical outcome were evaluated. Hormones and metabolites and cardiac metabolism were investigated concurrently as potential mechanisms of GIN therapy. The major findings of the present study are that GIN therapy reduced post-operative myocardial injury and myocardial dysfunction leading to a decrease in major complications following coronary artery bypass grafting surgery. The mechanism of the overall improvement in cardiac function and decreased morbidity following CABG with GIN therapy is likely to be multi-factorial, but from the present results, is influenced by improved myocardial metabolism. GIN therapy is thus an effective diet for the ischemic heart.
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Braun, Marle. "Total antioxidant capacity of stewed tomato and onion flavoured with parsley: effect of thermal household processing." Thesis, Cape Peninsula University of Technology, 2006. http://hdl.handle.net/20.500.11838/766.
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Thesis (MTech (Consumer Sciences: Food and Nutrition))--Cape Peninsula University of Technology, 2006<br>Fruit and vegetables are the major antioxidant contributors to the diet Antioxidants assist in
the prevention of oxidative damage in the body and may as a result prevent the causation of
degenerative diseases. Thermal household processing plays an integral part in South
African consumers' lives, as most fruit and vegetables consumed are processed at home.
Consumers' perceptions that food processing causes nutrient losses, especially of vitamin C,
have been corroborated by studies that investigated thermal household processing of single
foods or that of industrial processing. No studies have determined the effect of thermal
household processing on mixed dishes. A popular consumed South African mixed dish,
namely, stewed tomato and onion flavoured with parsley, was investigated by using three
recipes, each using a different preparation method. The traditional recipe for the preparation
of stewed tomato and onion was modified (control recipe) to contain parsley. Two other
recipes (Recipe 1 and 2) were compiled based on the recipe formulation of the control recipe
but differed in the preparation methods used. In Recipe 1, raw onion was added to cooked
tomato and in Recipe 2, sauteed onions were added to cooked tomato.
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Chan, Wing-yan Veronica, and 陳詠恩. "An examination of neuroprotective effects of 17B-estradiol and extracts from Panax Quinquefolius L., Ginkgo Biloba and HypericumPerforatum against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)induced nigral-striatal neuronal degeneration." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B3122720X.
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O’Gorman, Maurice R. G. "Reduced in vitro IgG secretion following in vivo injection of interferon (wellferon R) in multiple sclerosis patients." Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/24876.
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An in vitro IgG secretion assay was developed to investigate the regulation of the humoral immune response in humans. Pokeweed mitogen (PWM), a plant lectin derived from Phytolacca americana stimulates human peripheral blood mononuclear cells (PBMNC) to divide and resting B-lymphocytes to differentiate into immunoglobulin secreting cells (ISC). This differentiation requires that both monocytes and T-lymphocytes be present in the culture system. The amount of IgG secreted by these differentiated B-lymphocytes in response to PWM appears to be the net result of a balance between the functional activity of the regulatory T-helper and T-suppressor cells. Alterations, qualitative or quantitative in any of these leukocyte subsets could conceivably alter the amount of IgG secreted by the B-lymphocyte subpopulation.
We have employed this assay to investigate the immune status in a group of chronic progressive multiple sclerosis (MS) patients and to assess the immunoregulatory effects of interferon (Wellferon R, INF) administered in vivo to this selected group. Their mononuclear cells (MNC) were studied in this PWM induced IgG secretion assay before INF treatment and again after 7 days of daily sub-cutaneous injections (5 X 10⁶ u/day). Twenty patients received the interferon (INF) preparation and eighteen received normal saline. The study was carried out in a double blind manner and the code was broken only after individual results had been calculated.<br>Medicine, Faculty of<br>Pathology and Laboratory Medicine, Department of<br>Graduate
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Faghihi, Shahabeddin. "Effects of crystal size and orientation of novel titanium-based substrates on cell adhesion : implication for medical implants." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111882.
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The high performance of bone implants depends on the positive response of osteoblasts to the surface of the materials manufactured for the implant. Cell response in turn strongly depends on the nature of the initial interaction of macromolecules involved in cell adhesion and proliferation with the atomic structure of the surface of the material used for the implant. The initial interaction between bone specific extracellular matrix proteins and the solid substrate influences cell response at the cell-implant interface. This interaction is crucial for implant stability, long-term durability, and osseointegration. Despite extensive research undertaken to develop high-quality material for implants in order to improve the cell-substrate interaction, little is known about the significance of the atomic structure of the substrate and the role of molecular machinery involved in cell-substrate interaction. Using a combined approach involving material sciences and cell and molecular biology, the objectives of this research are to evaluate the response of pre-osteoblast and fibroblast cell lines to novel bulk polycrystalline and single crystal titanium based material and assess the role of crystal size and orientation.<br>Novel bulk nano-structured titanium substrates were produced by the process of high-pressure torsion (HPT). These materials have a significant advantage compared to conventional titanium-based materials by having higher surface wettablity, mechanical properties as well as a distinct surface oxide layer and atomic structure. A co-culture system was adapted to investigate the differential response of pre-osteoblast and fibroblast cell lines to titanium and titanium dioxide single-crystal substrates.<br>The results of this study provide clear evidence that crystal size and specific crystallographic orientation can be used to improve cell adhesion and proliferation. The nanostructured titanium substrates show strong interaction with pre-osteoblast cells as evident by the higher expression of fibronectin and the formation of extensive focal adhesion. Differential cell behaviour of pre-osteoblasts and fibroblasts are observed in cultures grown on the substrates with specific crystallographic orientations. The degree of cell attachment of the pre-osteoblasts is considerably higher on Ti-(1120) crystal face compared with the fibroblasts. These findings have profound implications for the improved osseointegration and inhibition of fibrosis leading to long-term implant consolidation and stability.
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Albacker, Turki B. "High dose insulin therapy in patients undergoing coronary artery bypass grafting (CABG)." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101833.
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This thesis is a step forward in evaluating insulin therapy and defining its role in cardiac surgery first described as Glucose-Insulin-Potassium (GIK) solution 40 years ago.<br>Chapter (I) includes a review of the literature on insulin therapy in cardiac surgery and illustrates the scientific bases and controversies in this therapy.<br>Chapter (II) entitled: "Myocardial Protection During Elective Coronary Artery Bypass Grafting Using High Dose Insulin Therapy" represents a manuscript that was presented in the following meetings: (A) Local meetings: (1) McGill cardiovascular research day, February 1/2007, Montreal, Canada. (2) Fraser Gurd annual research day, McGill surgery department, May 31/2007, Montreal, Canada. (B) National meetings: (1) 11th Annual Terrence Donnelly research day for Canadian cardiac surgery residents, May 26/2007, Toronto, Canada. (C) International meetings: (1) 43rd Annual meeting of the Society of thoracic surgeons (STS), January 30/2007, San Diego, United States. A full manuscript was submitted to "The Annals of Thoracic Surgery" for review.<br>Chapter (III) entitled: "High Dose Insulin Therapy Attenuates Systemic Inflammatory Response in Patients Undergoing Elective Coronary Artery Bypass Grafting" represents a manuscript that was presented in the following meetings: (A) Local meetings: (1) Fraser Guard McGill Surgery department annual research day, May 3/2006, Montreal, Canada. (B) National meetings: (1) 10th Annual Terrence Donnelly research day for Canadian cardiac surgery residents, May 26/2007, Toronto, Canada. (2) Young investigator forum, Canadian Society of Clinical Investigators (CSCI), September 28/2006, Ottawa, Canada. (3) 59 th annual meeting of Canadian Cardiovascular Society (CCS), October 21/2006, Vancouver, Canada. (C) International meetings: (1) American Heart Association (AHA), November 12/2006, Chicago, United states.<br>Abstracts from this work were published in the following journals: (1) Clinical and Investigative Medicine, Vol. 29, No. 4, August 2006. (2) The Canadian Journal of Cardiology, Vol. 22 supp D, October 2006 (3) Circulation, Vol. 114 supp, No. 18, October 2006.<br>A full manuscript was submitted to "the journal of thoracic and cardiovascular surgery" for review.
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衛穎賢 and Wing-yin Eric Wai. "Effect of herbal medicine (Ganoderma lucidum) on nitric oxide production in macrophages." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B3197126X.
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趙詠頤 and Wing-yee Chiu. "Effect of chronic green tea consumption on lipolysis in rats." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31970461.
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Liu, Jie, and 劉潔. "Intranasal dexmedetomidine for sedation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41508452.
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Naidoo, Leanne. "Soul tattoos : an exploration of the therapeutic self - the indelible and the disposable." Thesis, Nelson Mandela Metropolitan University, 2005. http://hdl.handle.net/10948/373.
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From a social constructionist perspective, the self of the therapist is the only tool that she takes into therapy with her. The study of the therapeutic self therefore becomes important as this impacts on the quality of therapy received by the client. This treatise explores the development of the researcher’s therapeutic self through the storying of significant learning experiences in the course of her training in counselling psychology. An analysis of the narrative reveals the substance of some of the soul tattoos that make up her therapeutic self. The study was undertaken from an action research approach, thus emphasising the investigation of the therapeutic self in the field and feeding this information back into the practice of counselling psychology in the course of the research project. The themes extracted in the analysis reveal the process of action learning and what constituted significant learning experiences for the researcher. The researcher found that certain conditions were required for the formation of soul tattoos and that merely obtaining a masters degree in counselling psychology was not sufficient preparation for the practice of counselling psychology.
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Miller, David West. "A critical incident study of poetry therapy." Thesis, University of British Columbia, 1991. http://hdl.handle.net/2429/31838.
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This study explores the effectiveness of poetry as an ancillary psychotherapeutic technique in a group counselling setting. Five adult immigrants/refugees (less than five years in Canada and who were learning English as an additional language) from Hong Kong, Iran, Guatamala, Colombia, and one Canadian Native Indian volunteered for and completed a workshop, "Settling in Canada", and participated in subsequent data collection procedures.
Flanagan's (1954) Critical Incident Technique was used to discover what poetic events facilitate and what poetic events hinder the process of settling in Canada. Non—poetic events were analysed in the same fashion.
Data was drawn from three sources. Two post—workshop critical incident interviews provided data from which 10 poetic and 8 non—poetic facilitating categories, and 1 poetic and 2 non—poetic hindering categories were induced. These categories were supported by workshop leader observations and by poetry produced by the participants.
The results indicate that poetry used in a variety of ways facilitates exploration of and expression of feelings, increases self—esteem and confidence, promotes dialogue among workshop participants and others, expands one's definition of self, and enhances personal problem solving. The participants in the Settling in Canada workshop stated that these factors helped them settle in Canada.<br>Education, Faculty of<br>Educational and Counselling Psychology, and Special Education (ECPS), Department of<br>Graduate
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Epasinghe, Don Jeevanie. "Applications of proanthocyanidin in dentistry." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/197558.
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In dentistry, repair and restoration of tooth structure to regain its mechanical properties is the ultimate aim of caries management. Currently, preventive therapies are preferred to operative interference. New preventive approaches are necessary to treat dental caries.
Dentine is composed of an organic matrix, consisting of type 1. Degradation of collagen matrix is the main reason for breakdown of resin-dentine bonds and development of secondary caries over time. Hence, preservation of collagen fibrils is essential for preventive and reparative procedures in minimum intervention dentistry. Proanthocyanidin (PA) is a natural collagen cross-linker, which can be obtained from grape seeds, pine bark or elm tree. It has a high affinity to proline-rich proteins, like collagen. Cross-linking of the collagen fibrils increases their mechanical properties and their resistance to breakdown by proteolytic enzymes.
Thus, in the first part of the study, with the aim of discovering other possible natural dentine collagen cross-linkers, the effect of two smaller molecular size flavonoids, naringin and quercetin, on the mechanical properties of demineralized dentine was compared to PA. Demineralized dentine treated with PA showed the greatest increase in mechanical properties, followed by quercetin and naringin. The protease inhibitory effect of PA was evaluated by examining its actions on soluble and collagen-bound matrix metalloproteinases and cysteine cathepsins. Proanthocyanidin, even at low concentration of 1%, exhibited excellent inhibitory effects on soluble and matrix-bound proteases.
Secondly, PA was incorporated in a dental adhesive to facilitate its application in clinical situations. The effect of PA incorporation on durability of resin-dentine bond was evaluated. Up to 2% of PA could be added to dental adhesive with no adverse effects on immediate resin-dentine bond strength. However, the bond strengths of PA-incorporated adhesives dropped significantly following ageing. This could be attributed to the free radical scavenging effect of PA, which might also have interfered with polymerization of dental adhesive.
The mechanical properties of PA-incorporated adhesive were evaluated and it was shown that up to 1% PA could be incorporated into an adhesive resin. With the addition of higher concentration of PA, the mechanical properties of the adhesive resin were reduced with increased solubility. Proanthocyanidin release from the cured resin showed an initial burst for 48 hours and was stabilized after five days.
Finally, the remineralization potential of PA on artificial root caries was also compared with quercetin and naringin. All three flavonoids showed remineralization potential; however, their effects were inferior to fluoride. Proanthocyanidin formed a precipitate band on the superficial layer of carious lesion, preventing further mineral deposition. Subsequently, PA was incorporated in a CPP-ACFP (casein phosphoproteins amorphous calcium fluorophosphates) containing-paste to increase the mineral uptake in subsurface layer of caries lesion. Simultaneous application of PA and CPP-ACFP was shown to have a favourable outcome on mineral deposition in root caries lesion.<br>published_or_final_version<br>Dentistry<br>Doctoral<br>Doctor of Philosophy
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陳澤楠. "淺論武夷肉桂茶的中醫學功效". HKBU Institutional Repository, 2016. https://repository.hkbu.edu.hk/etd_oa/235.
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本文主要通過查閱和收集近年來有關武夷肉桂茶及茶葉研究相關的文獻和文章，介紹了武夷肉桂茶的產地、生物特性、製作工藝、審評、他學組分、相關藥理作用的研究等各方面的內容。分析了武夷肉桂茶的性味歸經、中醫學功效進而提出了目前的研究中尚存的一些問題，以及對茶療這一療法今後的研究和發展方向表達了自己的見解。 武夷肉桂茶，無性奈、灌木型、小葉類、中晚生種。原產於國家一級自然保護區武夷山，香氣辛銳濃長似桂皮香。其含有多種營養成分和藥理活性成分，如茶多盼、茶氯酸、咖啡鹼、茶多糖、複合糖、茶皂素、有機酸、芳香物質、類胡蘿蔔素、葉綠素、黃闢類、維生素C 、多種B 屬維生素、維生素P 及磷、主甲、鈣、鎮、鋒、氣、晒等礦物元素，均為人體保健的功能性物質。 經過武夷岩茶的製作工藝後的肉桂茶，其性味表現為“味辛，甘，苦，性溫’歸心、肺、腎、胃經。具有發汗解肌、補火助陽、他氣行水、溫經通絡、溫通心陽、溫脾胃、提神醒腦等功效。可用於治療外戚表邪、膀恍氣化失常、痛痹、心陽不振、下元虛冷、脾胃虛寒等證。 近年來研究資料顯示：武夷肉桂茶中的有效成分具有抗菌抗病毒、增強免疫力、利尿、抗炎、降血脂和抗動脈粥樣硬化、抗凝血及抗血桂、降壓、降血糖、對中樞性和末梢性血管系統的興奮和強心作用等因此，肉桂茶可用於外戚風寒、前列腺增生、月經不調、精神不振、風濕性關節炎、類風濕性關節炎、冠心病、高血壓、高血脂、高血糖、胃腸疾病、等防治以及日常養生。 然而，對於武夷肉桂茶乃至整個茶療體系的研究還是存在著一些問題，例如沒有從中醫方面進行有關療效的闡述等。所以，我們在瞭解中醫茶療歷史的前提下及茶葉組分的藥理研究的背景下，應當重新審視茶的醫療保健價值，開拓臨床治療及養生保健的新思路。
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何翠歡. "中國清代茶葉藥用功能研究". HKBU Institutional Repository, 2015. https://repository.hkbu.edu.hk/etd_oa/124.
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在中國醫藥史上，茶用作於治病已有很長的歷史。人們在食用茶葉的過程中，積累了不少經驗，茶葉除了成為日常的飲料外，亦廣泛地應用於治療疾病上。本論文旨在了解清代的醫家及養生家對茶葉藥用功能的認識。清代的茶文化雖然沒有唐、宋及明代的雅興，但從地域、階層、茶類的廣度變化，及在茶功能的認識、飲茶方式、茶具製作、茶館文化等的深度變他，可見茶在清代有相當的發展。而在清代考證的學術風氣及實踐臨床醫學風氣的影響下，茶葉在清代醫療上，亦有廣度及深度的發揮。 從廣度而言，茶葉廣泛地用於各科病種，在內科、婦科、兒科、眼科、耳鼻喉科、口齒科、外科及傷科，茶葉都能發揮其治病的功能。而使用茶葉的方法， 亦有以單味茶葉、茶葉與諸藥合煎劑、茶調下方、外洗、外敷等，配合各種病症的需要而選擇使用。而深度而言，清代本草醫家對各種茶品的認識更為深入， 使用技巧更有深度。除了適當地運用不同品種、不同炮製方法的茶葉，利用其性昧、升降的不同， 治療不同的疾病。茶葉在組方上的使用更見靈活，使茶葉能針對不同的病症，充分地利用茶的特性，發揮茶的治病功能。清代綜合了前朝茶療的經驗及知識，又完備六大茶品，所以清代茶藥的應用，是傳統中醫藥對茶作為藥品的一個知識總結。了解清代醫家如何理解茶葉的性味、功能，如何將茶葉應用於臨床治病之中，對現代中醫藥的臨床治療及用藥亦有所啟發。 有鍵詞： 清代、茶療、茶葉功能
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Zhou, Shanshan. "Integrating multi-omics to investigate the correlation between the quality and efficacy of ginseng." HKBU Institutional Repository, 2019. https://repository.hkbu.edu.hk/etd_oa/693.
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Ginseng, the root and rhizome of Panax ginseng C. A. Mey. (Araliaceae), is one of the most famed dietary and medicinal herbs worldwide due to its multifaceted efficacies. Ginsenosides and carbohydrates are demonstrated the major bioactive components of ginseng. Ginseng materials are always formed under various conditions, e.g. different growth years or different post-harvest processing/handling manners. These conditions can impact chemical profiles and thereby cause different quality and efficacy of ginseng. To address this issue, it will be necessary to understand the correlation between the quality and efficacy of ginseng materials formed under different conditions. Previous studies have attempted to investigate how growth years and post-harvest processing/handling manners affect the quality and efficacy of ginseng. In the most of these cases, several chemical components and biological parameters were selected as the indicators for evaluating the quality and efficacy of ginseng, respectively. However, it has been well recognized that the therapy of ginseng is featured by "multiple components against multiple targets". Therefore, several selected indicators may fail to comprehensively characterize the quality and efficacy of ginseng, thus cannot accurately reveal their correlations. Instead, holism-based approaches should be employed. In this study, we integrated chemomics, metabolomics and gut microbiota genomics to investigate the correlation between the quality and efficacy of ginseng in the conditions of growth years, steam-processing and sulfur-fumigation. First, chemomics approach was developed to qualitatively and quantitatively determine major ginsenosides and carbohydrates (poly-, oligo- and monosaccharides) by ultra-high performance liquid chromatography-tandem triple quadrupole mass spectrometry (UHPLC-QqQ-MS/MS) and high performance liquid chromatography coupled with evaporative light scattering detector (HPLC-ELSD) for characterizing the overall quality of ginseng. Second, ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS/MS)-based metabolomics and 16S rRNA gene sequencing-based gut microbiota genomics coupled with biochemical parameters determination were performed to evaluate anti-fatigue and anti-obesity activities of the different ginseng on animal models. Third, the obtained multi-omics data were processed by multivariate statistical analysis and then were integrated to discuss the correlation between the quality and efficacy of ginseng materials in different conditions. The results indicated that: 1) ginseng with 4-6 growth years possessed different anti-fatigue activity in multiple targets due to the different effects of ginsenosides and carbohydrates on endogenous metabolism and gut microbiota; 2) steam-processing qualitatively and quantitatively altered ginsenosides and carbohydrates in ginseng, resulting in different anti-obesity activity between white ginseng and red ginseng, and the mechanisms potentially involve chemically structural/compositional specificity to gut microbiota; 3) SO2 residual content caused by sulfur-fumigation did not correlate with the quality, efficacy and toxicity changes of sulfur-fumigated ginseng, more specifically, less SO2 residue did not indicate higher quality, better efficacy nor weaker toxicity. The research provides scientific insights for guiding the clinical and dietary practice of ginseng and offers new methodology for comprehensively exploring the correlation between the quality and efficacy of herbal medicines
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文詩泳. "紫杉醇脂質體製備工藝和處方的改進". HKBU Institutional Repository, 2010. http://repository.hkbu.edu.hk/etd_ra/1134.
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Chen, Xiaoyu. "Investigation of liposomes and liposomal gel for prolonging the therapeutic effects of pharmaceutical ingredients." HKBU Institutional Repository, 2013. http://repository.hkbu.edu.hk/etd_ra/1524.
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Li, Sheng Nan. "Investigation on ion channel interactions and neuroprotective activities of novel peptides from medicinal coral." Thesis, University of Macau, 2018. http://umaclib3.umac.mo/record=b3952134.
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Hu, Yaxin, and 胡亞欣. "Biophysical interactions between therapeutic ultrasound and live cell." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/208032.
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Therapeutic ultrasound employs the acoustic energy carried by high-frequency mechanical wave to induce beneficial effects on living systems. This therapeutic approach is advantageous in that its energy could be remotely focused on the targeted tissue in a non-invasive manner. Although ultrasound therapy has been shown to be feasible and effective in both laboratory experiments and clinical trials, its safety and efficacy are still challenged by the lack of fundamental knowledge of how ultrasound wave exerts physical effects on the cell system and how the cell functionally responds to the ultrasound stimulation. Motivated by the above insight, this thesis aims to provide direct experimental evidence for illustrating the biophysical details of how ultrasound wave (alone or combined with microbubble) interacts with live cells.
An acoustic experimental platform with well-calibrated ultrasound field and live-cell imaging modality was developed to observe ultrasound-cell interaction. Based on this platform, a series of single-cell studies was then conducted to monitor the structural and functional changes of the live cell as well as its fluorescently-labelled components over the course of ultrasound exposure. Results obtained in this thesis provided image-level evidence for characterizing the ultrasound-cell interactions in the following three aspects. First, it was found that low-intensity ultrasound pulsing could directly perturb the plasma membrane, the cytoskeletal
network and the inner nucleus of live neuroblastoma cells. This cytomechanical perturbation would result in reversible and structural alternations of subcellular components. Second, low-intensity pulsed ultrasound, when applied on neuronal cells, could exert morphological impact through inducing neurite retraction and cell body displacement, and electrophysiological impact in the form of membrane depolarization and calcium influx. This finding verified the potential of ultrasound in modulating neuronal development and excitability. Last, the cell membrane perforation and resealing dynamics induced by the ultrasound-activated microbubble were visualized and characterized. The subsequent cellular responses to this ultrasound-induced sonoporation were also identified at both membrane and cytoskeleton levels.
The significance of this study is to provide direct and solid experimental evidence for understanding the biophysical interactions between ultrasound wave and live cell. This advanced scientific interpretation is definitely crucial for establishing the cellular mechanisms of therapeutic ultrasound and for providing technical insights into ultrasound treatment.<br>published_or_final_version<br>Electrical and Electronic Engineering<br>Doctoral<br>Doctor of Philosophy
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Peternelli, Loris. "The relationship between emotionality and in-session therapeutic phenomena." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0019/NQ37011.pdf.
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Chen, Chao, and 陳超. "Identification of a novel cancer therapeutic antibody against human epidermal growth factor receptor 2 (Her2) and antibody engineering for development of cancer therapeutics." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/196461.
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Cancer is one of the leading causes of death worldwide. Monoclonal antibodies (mAbs) have been proved effective for cancer therapy. MAbs possess advantages over chemical drugs and small molecular drugs in cancer treatment, such as high specificity, low toxicity, effector function, long half-life in circulation system and less side effects. There are eight FDA-approved anti-cancer antibody drugs now, and many more are under development. Antibodies have two functional domains, the Fab region that is responsible for antigen recognition, and the Fc region that couples the antibody to immune effector pathways. Fab-mediated interference with cancer cell signalling may lead to growth inhibition and direct cell death, while Fc-mediated effector function through interactions with Fc-gamma receptors (FcrRs) expressed in immune cells or through complement cascades may lead to target cell cytotoxicity. Antibody engineering to increase the binding affinity and effector function may improve antibody in vivo efficacy.
Anti-Her2 mAb herceptin (trastuzumab) is effective in treatment of Her2-overexpressing breast cancer patients. However, only 25–30% of patients with Her2-overexpressing tumors respond to single agent trastuzumab, and drug resistance develops even in responding patients. Accumulating evidence showed that cross-talk between Her2 and the insulin-like growth factor receptor type I (IGF-IR), including receptor heterodimerization and transactivation, and elevated IGF-IR signalling have been associated with trastuzumab resistance. Therefore, we hypothesized that dual specific antibodies co-targeting both IGF-IR and Her2 may prevent or delay the emergence of resistance to mono-specific antibodies. Mouse monoclonal antibody, M590 showed very good binding activity to IGF-IR. By engineering the CH3 domain of human Fc in pDR12 plasmid, we developed a “knobs-into-holes” hybrid IgG expression system, and successfully produced M590-Herceptin bi-specific IgG, which showed high binding avidity for both antigens and preserved antibody-dependent cell-mediated cytotoxicity (ADCC), a main route of immune protections conferred by therapeutic antibodies in vivo. M590-Herceptin dual specific antibody inhibited breast cancer and ovarian cancer cell proliferation in vitro, and inhibited cancer growth in a SKOV-3 Her2- and IGF-IR-overexpressing ovarian cancer xenograft mouse model. M590-Herceptin hybrid showed better anti-cancer activity compared with M590 and Herceptin alone, or in combination.
Meantime, I also constructed a phage display antibody Fab library using the mRNA of rabbits immunized by membrane proteins of SKOV-3 cells, and isolated a novel anti-Her2 mAb, designated as 1C6. Results from in vitro assays showed that 1C6 had anti-cancer activity which was comparable to that of herceptin. M590-1C6 hybrid IgG was also constructed, and the results from in vitro assays and mouse study showed that M590-1C6 hybrid IgG also possess better inhibitory activity of Her2 positive tumours compared with m590 or 1C6 alone. In summary, this study indicates that bi-specific antibodies co-targeting two elevated cancer receptors are more effective than mono-specific antibodies for cancer therapy.<br>published_or_final_version<br>Microbiology<br>Doctoral<br>Doctor of Philosophy
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Zhang, Jingxuan, and 张静璇. "Therapeutic landscape in high-density urban environment." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B4754479X.
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Hong Kong’s compacted urban form brings about potential problems including mental illness. Meanwhile stressful life mainly originates from working pressure brought a lot of physical and mental problems for the people themselves and generating serious family and social problems. As more and more people start to aware mental health issue, the current mental health services system is no longer sustainable due to increasing number of patients. This thesis aims to excavate the potential for landscape to become element in healthcare delivery in the context of community as following: refine the definition of therapeutic landscape, define the scope of work, and identify components essential for therapeutic environment. Last but not least, dig out possible interpretation/physical form through set an example of a particular design introduce for a typical site.
Therapeutic landscape which introduce to community recreation system will become a new approach to backup mental health service system as well provide people more convenient and broad healthcare service to cultivate healthy personality. Thus promote community organic development to become a thoughtful and institutional environment.<br>published_or_final_version<br>Architecture<br>Master<br>Master of Landscape Architecture
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Thomas, Becky L. "The Use of Therapeutic Rituals in Substance Abuse Treatment." DigitalCommons@USU, 2001. http://digitalcommons.usu.edu/etd/2712.
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This study explored the use of rituals in substance abuse counseling. Data were obtained from a total of 25 mental health workers in the substance abuse field from the northern region of Utah. Four research questions were asked about rituals and their use in substance abuse counseling: (I) Are addictions therapists using rituals? (2) How did therapists determine when to use rituals? (3) What types of rituals do they use? and (4) How do therapists assess ritual effectiveness? Results indicated that about three fourths of the mental health workers questioned were using rituals in their treatment protocol with substance abuse clients. The most common methods used for determining when to implement rituals into treatment were (a) clients were emotionally stuck, (b) client's cognitive ability, and (c) therapist's perception. The findings also suggested that therapists presented means of assessing the effectiveness of the rituals they implemented, but the data also supported past literature findings that showed little empirical means of assessment.
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Kjellin, Jessica, and Sara Norman. "Arbetsterapeutstudenters utvecklande av ”therapeutic use of self” - En litteraturstudie." Thesis, Örebro universitet, Institutionen för hälsovetenskaper, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-84409.
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Treece, Christine A. "Psychologists' Use of Dogs in Psychotherapy: A Therapeutic Exploration." Antioch University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=antioch1554402231989459.
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Hakala, John C. "The therapeutic use and effectiveness of humor in psychotherapy." Online version, 1998. http://www.uwstout.edu/lib/thesis/1998/1998hakalaj.pdf.
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PULIGA, ELISABETTA. "POTENTIAL THERAPEUTIC USE OF TRIIODOTHYRONINE (T3) IN HEPATOCELLULAR CARCINOMA." Doctoral thesis, Università degli Studi di Cagliari, 2018. http://hdl.handle.net/11584/255968.
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Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver with a poor prognostic outcome due to limited and ineffective therapeutic strategies. Thus, it is mandatory to develop more efficient and powerful treatments for this aggressive tumor. Recent studies have suggested the possible role of local hypothyroidism in HCC development, in both humans and rodents. Previous observations from our laboratory showed that 1-week exogenous administration of triiodothyronine (T3) induced the regression of preneoplastic hepatic nodules generated by the Resistant Hepatocyte (RH) model of rat hepatocarcinogenesis.
The first aim of this study was to investigate the mechanism/s responsible for the rapid regression of preneoplastic nodules observed 1 week after T3. Transcriptomic analysis showed that a short administration of T3 caused a striking shift of the global expression profile of the aggressive preneoplastic nodules positive for the presumptive progenitor marker cytokeratin-19 (KRT-19) towards that of normal liver or of the indolent KRT-19 negative lesions. This reprogramming preceded the regression of the nodules and was associated with increased mRNA levels of genes involved in the maintenance of differentiated hepatocyte status such as Hnf4-α and Klf9. These changes were associated with the activation of the T3/Thyroid hormone receptor (TR) axis in KRT-19+ hypothyroid nodules, as shown by a striking increase of Dio1 mRNA levels.
Unfortunately, the diagnosis of human HCC is too often made at late stages, when there are no effective treatments that would improve patients’ survival. Therefore, a second aim of my thesis was to determine whether T3 could exert its anti-tumoral effect also when administered to HCCs bearing rats. Remarkably, we found that 5 cycles of T3 (one week every three weeks) induced the regression of HCCs as observed both at macroscopic as well as at microscopic examination. Indeed, while the liver of all the rats not exposed to T3 displayed multiple HCCs, treatment with T3 reduced the multiplicity of the tumors and the tumor burden. Similar to what was found in preneoplastic nodules, we observed increased expression of genes involved in the maintenance of the hepatocyte differentiated status such as Klf9, Cebpα and Hnf4-α, paralleled by the loss of neoplastic markers such GST-P and KRT-19. Furthermore, we also demonstrated the ability of T3 to reactivate the T3/TR axis in fully developed HCCs.
Collectively, these results suggest that T3 acts as a powerful anti-tumoral agent at early and late stages of rat HCC development, in virtue of its differentiating capacity. They also suggest that recently developed thyromimetic drugs, devoid of T3-induced adverse side effects, represent a promising tool in human HCC therapy.
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Vezmar, Marko. "Pharmacological effects of quinoline-related compounds in human tumour cells overexpressing the multidrug resistance protein (MRP)." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0003/MQ37175.pdf.
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Pathy, Kala. "Bioavailability problems in clinical neuropharmacology with special reference to (1) generic phenytoin and (2) madopar HBS." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1994. http://hub.hku.hk/bib/B31214551.
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Wong, Lai-Ming Ella, and 黃禮明. "Iron and ruthenium complexes with nitrogen and oxygen donor ligands for anti-cancer and anti-viral studies." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B3587742X.
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Gopalakrishnan, Vaishnavi Lekshmi. "Remineralization of initial carious lesions using CPP-ACP reagents in vitro." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45591313.
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