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Dissertations / Theses on the topic 'Therapeutics'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Lopez, Aguilar Aime. "Peptides as therapeutics." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:d893e962-5cb9-4d50-bbe1-c5183418295c.

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Peptides have attracted increasing attention as therapeutics in recent years, at least partially as a consequence of the widespread acceptance of protein therapeutics; but also as possible solutions to problems such as short half-life and delivery of molecules, and as therapeutics in their own right. The current work presents three projects that involve applications of peptides in a therapeutic environment. The first project studies the use of ER retaining peptides and CPPs (Cell penetrating peptides) in enhancing the effective concentration of DNJ (1-deoxynojirimycin), an α-glucosidase inhibi

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2

Balivada, Sivasai. "Cell mediated therapeutics for cancer treatment: tumor homing cells as therapeutic delivery vehicles." Diss., Kansas State University, 2013. http://hdl.handle.net/2097/16890.

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Doctor of Philosophy<br>Department of Anatomy and Physiology<br>Deryl L. Troyer<br>Many cell types were known to have migratory properties towards tumors and different research groups have shown reliable results regarding cells as delivery vehicles of therapeutics for targeted cancer treatment. Present report discusses proof of concept for 1. Cell mediated delivery of Magnetic nanoparticles (MNPs) and targeted Magnetic hyperthermia (MHT) as a cancer treatment by using in vivo mouse cancer models, 2. Cells surface engineering with chimeric proteins for targeted cancer treatment by using in vitr

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3

Gunnam, Mallikarjunareddy. "Novel anti-norovirus therapeutics." Thesis, Wichita State University, 2013. http://hdl.handle.net/10057/6818.

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Noroviruses are the most common cause of acute gastroenteritis, accounting for over 23 million cases annually in the U.S. alone. Norovirus infections constitute an important health problem for which there are no specific antiviral therapeutics or vaccines. In this thesis, (a) structure-activity relationship studies were carried out using the acyclic sulfamide scaffold. Several derivatives based on this scaffold were found to inhibit norovirus in a cell-based replicon system and, (b) a series of bisulfite adducts derived from representative transition state inhibitors (dipeptidyl aldehydes and

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4

Hill, Jonathan B. "Deoxyvariolins and polymer therapeutics." Thesis, University of Canterbury. Chemistry, 2005. http://hdl.handle.net/10092/6695.

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Polymeric carrier molecules have been shown to improve the pharmacokinetics and pharmacological profile of small-molecule anticancer drugs. The variolins are a group of marine natural product-derived cytotoxins whose clinical efficacy may be improved through conjugation with a polymer backbone. This thesis first describes the optimisation of a synthesis of the non-natural analogue deoxyvariolin B, a synthesis that was devised by Anderson and Morris immediately prior to the commencement of this project. The synthesis, comprised of six linear steps, was refined to give an overall yield of 25%.

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5

Reynolds, Francis M. M. B. A. Massachusetts Institute of Technology. "InVivo Therapeutics® Corporation." Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/37231.

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Thesis (M.B.A.)--Massachusetts Institute of Technology, Sloan School of Management, 2006.<br>Includes bibliographical references (leaf 100).<br>To date, the primary treatment for spinal cord injuries has been the use of spinal fixation devices to create a stable environment for the spinal cord to heal. The second treatment option is to remove soft tissue near and around the spinal cord intended to reduce pressure on the spinal cord and allow the spinal cord to heal on its own. InVivo Therapeutics Corporation is a startup founded to commercialize novel science and technology that was developed

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6

O'Malley, Jennifer A. "Improving therapeutics for Parkinson's disease." Cincinnati, Ohio : University of Cincinnati, 2009. http://rave.ohiolink.edu/etdc/view.cgi?acc_num=ucin1259079683.

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Thesis (Ph.D.)--University of Cincinnati, 2009.<br>Advisor: Kathy Steece-Collier. Title from electronic thesis title page (viewed Apr. 26, 2010). Keywords: Parkinson; dopamine; dyskinesia; levodopa; dendritic spine; medium spiny neuron. Includes abstract. Includes bibliographical references.

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7

Langford, Nigel James. "Beta-receptor pharmacology and therapeutics." Thesis, University of Birmingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404060.

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8

Derfus, Austin Matthew. "Toward multifunctional nanoparticle-based therapeutics." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2006. http://wwwlib.umi.com/cr/ucsd/fullcit?p3254426.

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Thesis (Ph. D.)--University of California, San Diego, 2006.<br>Title from first page of PDF file (viewed May 3, 2007). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 121-135).

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9

Sutter, Julianne V. "ASSESSING IMPACT OF AFFECT RECOGNITION ON THERAPEUTIC RELATIONSHIP." UKnowledge, 2010. http://uknowledge.uky.edu/gradschool_theses/14.

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Therapeutic alliance and its relationship to client nonverbal behavior, specifically facial expressions, were examined. Therapist interpretation of the client nonverbal behavior, or affect, influences the therapeutic alliance and process. Based on a sample of clients from a graduate school therapy training facility, results suggest therapist training in facial expressions, and how they relate to client emotion, improve the therapeutic alliance between therapist and client. After a micro-expression training for therapists, clients reported higher life functioning on the Outcome Rating Scale (OR

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10

Chiu, Shih-Jiuan. "Receptor-mediated DNA-based therapeutics delivery." Columbus, Ohio : Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1127403022.

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11

Bashar, A. M. A. Emran. "Cell based therapeutics for retinal degenerations." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/58180.

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Vision loss, due to retinal degeneration, is one of the major disabilities in the developed world. Cell based therapeutics showed promising results in preventing retinal degenerations. Here, mesenchymal stem cells have been used to develop therapeutics for two different disorders. First, the innate paracrine activity of the Mesenchymal Stem Cells (MSCs) has been utilized to prevent neurodegeneration in a rodent model (S334ter-4) of Retinitis Pigmentosa. To deliver a significant number of cells to the rodent retina, a novel magnetic targeting approach was applied. The MSCs were pre-labelled wit

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12

Smith, Mathew Wayne. "Phage display and experimental brain therapeutics." Thesis, Cardiff University, 2009. http://orca.cf.ac.uk/55853/.

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Phage display, a powerful polypeptide display technology, affords the rapid identification of peptides and proteins that interact with a target of interest The aims of the project were the phage display identification of peptides that interact with a druggable target in a brain disorder (glioblastoma multiforme) and the identification of peptides that serve as targeting vectors for brain delivery. Validation studies were undertaken to qualify the use of a cyclic 7-mer peptide phage library against targets including streptavidin and paracetamol chosen as examples of a large complex and small si

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13

Watson, Judy J. "Neurotrophins and their receptors as therapeutics." Thesis, University of Bristol, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.431610.

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14

Woffindale, Caroline A. "RNA-based therapeutics for Alzheimer's disease." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:8abb9f7b-9e49-4063-8395-83a57e9b14f7.

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Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterised pathologically by the accumulation of amyloid-β plaques and neurofibrillary tangles within the brain. Currently, there are no disease-modifying therapeutic interventions available. This thesis describes the development and delivery of novel RNA-based therapeutics for AD. Recently, significant advances have occurred in the field of RNA interference (RNAi)-based therapeutics, allowing targeted silencing of disease-relevant genes through the use of short interfering RNAs (siRNAs) or microRNAs (miRNAs). However, dev

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15

Ordway, Gregory A. "The Norepinephrine Transporter: Biology and Therapeutics." Digital Commons @ East Tennessee State University, 2007. https://dc.etsu.edu/etsu-works/8647.

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Chiu, Shihjiuan. "Receptor-mediated DNA-based therapeutics delivery." The Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=osu1127403022.

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17

Hill, Marcus Peter. "Design of novel tobramycin loaded therapeutics." Thesis, Queen's University Belfast, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.706976.

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18

Telussa, Rallya. "Reclaiming the Activity of Lost Therapeutics." Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/6411.

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ESKAPE pathogens are notorious in causing nosocomial infections and escaping current antibiotic treatments. There has been a dramatic increase in nosocomial infections accompanied with a decrease in the number of antibiotics developed, leading to significant increase in morbidity and mortality among patients. In an attempt to combat this problem, derivatives of ciprofloxacin, rifabutin and beta-lactam antibiotics were synthesized and tested against the ESKAPE pathogens. From minimum inhibitory concentration assays, 4 ciprofloxacin analogs and 8 beta-lactam analogs were found to be effective ag

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19

Southwell, Amber L. Schuman Erin Margaret Patterson Paul H. "Intrabodies as therapeutics for Huntington's disease /." Diss., Pasadena, Calif. : California Institute of Technology, 2009. http://resolver.caltech.edu/CaltechETD:etd-06082009-164212.

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20

Kohler, Nathan. "Superparamagnetic nanoparticles for cancer diagnostics and therapeutics /." Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/10565.

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21

Dahl, Kjell. "Human colorectal cancer : experimental staging and therapeutics /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-154-8/.

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22

Shonk, David Knight. "An investigation into the therapeutics of architecture." Thesis, Georgia Institute of Technology, 1990. http://hdl.handle.net/1853/21736.

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23

Alkhamesi, Nawar Abdul-Hadi Saleh. "Intraperitoneal delivery of therapeutics in laparoscopic surgery." Thesis, Imperial College London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.438982.

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24

Deacon, Samuel Philip Edward. "Bioresponsive polymer therapeutics containing coiled-coil motifs." Thesis, Cardiff University, 2009. http://orca.cf.ac.uk/55819/.

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Polyethyleneglycol (PEG) conjugates of peptides, proteins and an aptamer are in routine clinical use as first generation nanomedicines. Here a new family of polymer therapeutics based on PEG conjugates containing a coiled-coil peptide motif as a molecular switch are proposed. The coiled-coil motif is adopted by many naturally occurring proteins/peptides, including transcription factors key to cancer progression (E2F1/AP-1) and Ebola virus proteins (VP35/GP2). These were chosen as the first targets, however there is potentially a much wider role for this novel family of therapeutics. First stud

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25

Petrilli, Guinart Alejandra. "Target validation for Neurofibromatosis Type 2 therapeutics." Doctoral diss., University of Central Florida, 2013. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/6339.

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Neurofibromatosis type 2 (NF2) is a benign tumor disease of the nervous system. Development of bilateral vestibular schwannomas is characteristic of NF2; however patients frequently present schwannomas on other nerves, as well as meningiomas and ependymomas. Currently, there are no drug therapies for NF2. There is an urgent need for development of NF2 therapeutics and this dissertation presents two independent potential therapeutic targets. The disease is caused by mutations in the NF2 gene that encodes a tumor suppressor called merlin. Loss of merlin function is associated with increased acti

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26

Campbell, Sarah Elizabeth. "Targeting gene-based therapeutics for canine osteoarthritis." Thesis, University of Glasgow, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419179.

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27

Scotti, F. "Novel potential peptide therapeutics for tuberculosis therapy." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1544707/.

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Despite the existence of vaccinations, diagnostic tools and treatments, tuberculosis (TB) prevalence is increasing because of the circulation of people and misuse of antibiotics, giving rise to growing numbers of drug resistant strains of Mycobacterium tuberculosis. There is therefore a pressing need to look for new strategies against TB, in the hope of finding new drugs with novel mechanisms of anti-tubercular action or ways to potentiate the activity of already existing drugs and reduce treatment duration. This thesis explores the employment of peptides in anti-tuberculosis therapy. The proj

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28

Collins, Patrick. "The Galectins as Targets for Cancer Therapeutics." Thesis, Griffith University, 2013. http://hdl.handle.net/10072/365234.

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The galectins are the most ancient and widely expressed family of glycan-binding protein, and have been found in all metazoans examined to date. Galectins recognise and bind to carbohydrate ligands, specifically those that contain β-galactosides, and it is via these interactions, and through direct protein–protein interactions, that the galectins perform their highly diverse collection of activities. In humans, the galectins are found in both the intracellular and extracellular environments, and have important roles in many aspects of cellular homeostasis, cell signalling, and cell adhesion. O

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29

Sklepari, Meropi. "Stability and biophysical characterisation of protein therapeutics." Thesis, University of Warwick, 2017. http://wrap.warwick.ac.uk/98558/.

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For the past two decades, the development of protein therapeutics has significantly expanded with numerous biopharmaceutical and biosimilar products entering the medicine market every year, and even more queuing in the pipeline globally. Biologics are very complex molecules and therefore extremely sensitive to minor changes in the manufacturing process, which can result in heterogeneity and affect the stability, potency and immunogenicity of the final product. Public health organisations, such as EMA (European Medicines Agency), require that biological products should be extensively tested for

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30

Spagnolli, Giovanni. "Folding, Misfolding and Therapeutics in Prion Diseases." Doctoral thesis, Università degli studi di Trento, 2021. http://hdl.handle.net/11572/308935.

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Prion diseases are rare neurodegenerative disorders affecting humans and other animals, caused by a proteinaceous infectious agent named prion. The pivotal event in these pathologies is the conversion of PrPC, a physiologically expressed protein of poorly characterized function, into a misfolded conformer, named PrPSc, which is capable of replicating its conformationally-encoded information by inducing the conversion of its physiological counterpart. The aggregates resulting from this misfolding process accumulate in the central nervous system of affected organisms leading to neuronal death. P

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31

Spagnolli, Giovanni. "Folding, Misfolding and Therapeutics in Prion Diseases." Doctoral thesis, Università degli studi di Trento, 2021. http://hdl.handle.net/11572/308935.

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Prion diseases are rare neurodegenerative disorders affecting humans and other animals, caused by a proteinaceous infectious agent named prion. The pivotal event in these pathologies is the conversion of PrPC, a physiologically expressed protein of poorly characterized function, into a misfolded conformer, named PrPSc, which is capable of replicating its conformationally-encoded information by inducing the conversion of its physiological counterpart. The aggregates resulting from this misfolding process accumulate in the central nervous system of affected organisms leading to neuronal death. P

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32

Lang-Hua, Bich Hue, and 梁許碧蕙. "Decision-making in dental treatment planning: to maintain or to extract compromised teeth." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B50534282.

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Background: A number of systematic reviews provide the basis for decision-making in treatment planning of the reconstruction of mutilated dentitions. This includes identifying teeth difficult to treat/save and decisions on replacement such teeth if extracted. Aims: 1) To assess attitudes of general dental practitioners (GDPs) in a community where provision of dental implants is a widely practiced treatment; and to determine variations in attitudes with respect to dentists’ factors, training factors and implant-provision factors (Study 1): and 2) To determine treatment decision making w

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33

Parfitt, Natalie Rae. "Investigations of the assessment of bioequivalence of topical clotrimazole products using a dermatopharmacokinetic approach." Thesis, Rhodes University, 2010. http://hdl.handle.net/10962/d1007659.

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The specialised nature of the stratum corneum makes it an efficient barrier to foreign substances, including drug molecules. Therefore, cutaneous drug absorption is a slow and complex process of which stratum corneum penetration is the rate limiting step. The rate and extent of stratum corneum penetration by a drug compound depends greatly on the presence of penetration enhancing/retarding excipients and therefore the clinical outcomes of a product rely greatly on the components and quality of the formulation. Hence, establishing bioequivalence between topical products is crucial to ensure tha

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34

Fraser, Andrew Gordon. "The elimination of susceptibility bias in the study of adult female class II division 1 cases treated either with orthognathic surgery or orthodontics : a project report submitted as partial fulfilment for the degree of Master of Dental Surgery /." Title page, contents and summary only, 1997. http://web4.library.adelaide.edu.au/theses/09DM/09dmf841.pdf.

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35

Rafiq, Sarwish. "Evaluation of Antibody-based Therapeutics in B cell Malignancies." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1338321515.

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36

McCrudden, Maeliosa Theresa Christine. "Characterisation of small protease inhibitors as potential therapeutics." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492028.

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Neutrophil-derived serine proteases provide one of the first lines of defense against infection in innate immunity. However, in some disease states, the activity of these proteases becomes excessive and prolonged and so novel lead molecules with the potential to inhibit the excessive activity of these proteases in disease states are constantly being sought. In the current study, three proteinaceous protease inhibitors were chosen for characterisation. The specificity of the Escherichia coli trypsin inhibitor (ecotin) was modulated by site-directed mutagenesis studies; the elastase and cathepsi

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37

Chen, Sam. "Lipid nanoparticles for delivery of nucleic acid therapeutics." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/58637.

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Nucleic acid therapies have the potential to enable the treatment of disorders previously untreatable. However, significant barriers prevent the rapid development of nucleic acid therapeutics and necessitate the use of sophisticated delivery systems. The overall objective of this dissertation is to develop more effective and tolerable lipid nanoparticles (LNPs) for nucleic acid delivery. Specifically, LNP that vary in size, stability and composition were tested for activity after subcutaneous and intravenous injection in order to optimize LNP properties. Furthermore, the incorporation of novel

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38

Conrad, David Paul. "Development of Vesiculovirus-based Therapeutics for Acute Leukemia." Thesis, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31743.

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Outcomes for most patients with acute leukemia remain dismal. In-vitro, vesiculovirus members induced rapid apoptosis of acute leukemia cells. Intravenous injection of lymphoblastic leukemia cells infected ex-vivo with attenuated Vesicular Stomatitis Virus or Maraba Virus followed by gamma-irradiation, controlled leukemic progression in murine recipients. Essential properties of this autologous vaccine [immunotherapy by Leukemia-Oncotropic Virus (iLOV)] and the host’s immune system were characterized. iLOV durability was restricted to the leukemia used to manufacture the vaccine. At administra

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39

Tan, Ee Lyn. "Drug and Therapeutics Committees: Studies in Australian hospitals." University of Sydney. Pharmacy Practice, 2005. http://hdl.handle.net/2123/711.

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Australia�s policy on Quality Use of Medicines (QUM) aims to achieve appropriate use of medicines and improved health outcomes. Drug and Therapeutics Committees (DTCs) are educators, policy makers as well as financial gatekeepers in matters relating to medicine use. Increasingly, DTCs are also involved in risk management and clinical governance. As such, DTCs could be considered to be QUM advocates in the institutions in which they function. In a health care arena where there are escalating demands on high standards of clinical practice, quality assessment and improvement is essential in ensur

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40

Scott, Lauren. "Multifunctional pro-ligands as potential Alzheimer’s disease therapeutics." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/10317.

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Alzheimer’s disease is the most common form of dementia, affecting more than 24 million individuals worldwide. Although the exact causes of disease development and progression are unknown, the amyloid hypothesis links the observed pathologies of elevated metal ion levels (Cu²⁺, Fe³⁺, Zn²⁺), deposition of amyloid peptide in senile plaques, oxidative stress and neurodegeneration in a cohesive manner. As part of a possible intervention for this process, a series of multifunctional pyridinone pro-ligands were designed and synthesised. 3-Hydroxy-4-pyridinones display a high affinity for metal ions

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Srivastava, Vinit. "Response of medulloblastoma cell lines to experimental therapeutics." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=66723.

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Medulloblastoma is the most common malignant childhood brain tumour. The discovery of stem-like cells in malignant cancers has provided an alternative hypothesis for tumour initiation and progression. Given the toxicities associated with conventional therapies, developing therapies targeting aberrant molecular pathways or stem-like cells in medulloblastoma may improve overall survival and quality of life. Numerous reports have indicated that stem-like cells also exist in long-established cultured cell lines. Therefore, we first determined whether the DAOY medulloblastoma cell line

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Guillemard, Véronique. "Design and chemical synthesis of selective cancer therapeutics." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85073.

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The clinical use of chemotherapeutic agents against malignant tumors is successful in many cases but suffers from major drawbacks. One drawback is the lack of selectivity which leads to severe side effects and limited efficacy, and another is the emergence/selection of drug-resistance. To limit non-specific toxicity and to improve the efficiency of cancer therapy, "tumor markers", which are proteins generally overexpressed on the surface of tumor cells, can be selectively targeted.<br>Growth factor receptors are one of the most extensively studied groups of tumor markers. The implicatio

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Attard, Gerhardt. "Novel therapeutics and biomarkers for human prostate cancer." Thesis, Institute of Cancer Research (University Of London), 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.511508.

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Magnusson, Johannes Pall. "Smart" polymer therapeutics towards new architectures and applications." Thesis, University of Nottingham, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.523592.

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Wong, Xing-Wei. "Model-Based Therapeutics for Type 1 Diabetes Mellitus." Thesis, University of Canterbury. Mechanical Engineering, 2008. http://hdl.handle.net/10092/1573.

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The incidence of Type 1 diabetes is growing yearly. Worryingly, the aetiology of the disease is inconclusive. What is known is that the total number of affected individuals, as well as the severity and number of associated complications are growing for this chronic disease. With increasing complications due to severity, length of exposure, and poor control, the disease is beginning to consume an increasingly major portion of healthcare costs to the extent that it poses major economic risks in several nations. Research has shown that intensive insulin therapy aimed at certain minimum glycosylat

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Qiao, Boling. "Lead compounds for prion therapeutics from Chinese herbs." Thesis, University of Sheffield, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.445123.

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Tomlinson, Ryan. "Degradable polyacetals for the development of polymer therapeutics." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408018.

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48

Rowley, Laura Elizabeth. "Determining the cellular localisation of novel cancer therapeutics." Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/6179/.

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Three areas of investigation regarding a novel class of anti-cancer therapeutics, triple-helicate dinuclear compounds known as ‘cylinders’, have been addressed. An improved protocol for the synthesis of a ruthenium cylinder has been developed, utilising microwave synthesis rather than reflux techniques. The use of Sephadex C-25 as a solid phase for column chromatography led to shorter purification protocols. Experiments to determine the cellular localisation of fluorescent ruthenium cylinder using confocal microscopy showed fluorescence within MDA-MB-231 cells, but not within SKOV-3 cells, sug

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Ren, Yin Ph D. Massachusetts Institute of Technology. "Tumor-penetrating delivery of small interfering RNA therapeutics." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/72914.

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Thesis (Ph. D. in Medical Engineering)--Harvard-MIT Program in Health Sciences and Technology, 2012.<br>Vita. Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 234-250).<br>Efforts to sequence cancer genomes have begun to uncover comprehensive lists of genes altered in cancer. Unfortunately, the number and complexity of identified alterations has made dissecting the underlying biology of cancer difficult, as many genes are not amenable to manipulation by small molecules or antibodies. RNA interference (RNAi) provides a direct way to assess and act on putative can

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Rifai, Bassel. "Cavitation-enhanced delivery of therapeutics to solid tumors." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:374b2ee1-0711-4994-8434-bf90358d9e47.

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Poor drug penetration through tumor tissue has emerged as a fundamental obstacle to cancer therapy. The solid tumor microenvironment presents several physiological abnormalities which reduce the uptake of intravenously administered therapeutics, including leaky, irregularly spaced blood vessels, and a pressure gradient which resists transport of therapeutics from the bloodstream into the tumor. Because of these factors, a systemically administered anti-cancer agent is unlikely to reach 100% of cancer cells at therapeutic dosages, which is the efficacy required for curative treatment. The goal

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