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1
Legge, Kieron D. "Water soluble phthalocyanines for photodynamic therapy." Thesis, Keele University, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.401049.
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Atilgan, Serdar. "Water Soluble Distyryl-boradiazaindacenes As Efficient Photosensitizers For Photodynamic Therapy." Master's thesis, METU, 2006. http://etd.lib.metu.edu.tr/upload/12607601/index.pdf.
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Photodynamic therapy (PDT) is an emerging treatment modality for a range of disease classes, both cancerous and noncancerous. This has brought about an active pursiut of new PDT agents that can be optimized for the unique set of photophysical characteristics that are required for a succesful clinical agent. There are many reported or commercially available photosensitizers, but most have limitations, such as low photostability, or a limited usable range of solvent conditions.
In this study, we introduced a novel class of extended conjugation water soluble boradiazaindacene dyes which are efficient singlet oxygen generators. These sensitizers have strong absorptions in the therapeutic window and have spectacular photoinduced cytotoxicity. In addition, they display no dark toxicity at the active concentrations. With these remarkable properties, they are likely to find applications as promising new reagents for photodynamic therapy.
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Sharman, Wesley M. "Novel water-soluble phthalocyanines for photodynamic therapy and nuclear imaging." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0012/MQ26615.pdf.
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Sharman, Wesley Milton. "Novel water-soluble phthalocyanines for photodynamic therapy and nuclear imaging." Mémoire, Sherbrooke : Université de Sherbrooke, 1997. http://savoirs.usherbrooke.ca/handle/11143/3127.
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Bryden, Francesca. "Synthesis of water-soluble porphyrin-dendron conjugates for targeted photodynamic therapy." Thesis, University of Hull, 2013. http://hydra.hull.ac.uk/resources/hull:17231.
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The targeting of photosensitisers with tumour-associated biomolecules is widely used for improved photosensitiser tumour localisation during photodynamic therapy, allowing fewer side effects in comparison to conventional cancer treatments. In particular, conjugation to antibody fragments allows exploitation of their high affinity towards tumour-associated antigens; however current methods of conjugating porphyrins to antibody fragments represent a compromise between high binding ratios and good stoichiometric and site-specific control. The work presented herein addresses this problem through the synthesis of porphyrin-dendron conjugates and their attachment at the interchain disulfide bridge of antibody fragments, allowing improved binding ratios while maintaining good structural control. Synthesis of a range of click-functionalised porphyrins and dendrons bearing complimentary peripheral functionalities was carried out, followed by click conjugation of these structures under microwave irradiation to produce a range of lipophilic and hydrophilic porphyrin-dendron conjugates with between two and four peripheral porphyrins. Photophysical evaluation demonstrated retention of UV-vis and fluorescent character of porphyrins after conjugation, with some quenching of UV-vis absorption observed due to the close proximity of the porphyrins. Singlet oxygen quantum yields showed some quenching in all conjugates, with more sterically hindered systems showing the greatest reduction in SOQY in comparison to control porphyrins. Conjugation of porphyrins to a HER2-targeted Herceptin™ Fab fragment was carried out through pre-conjugation of an alkyne-dibromomaleimide heterobifunctional linker to the Fab fragment, with two examples of cationic porphyrins conjugated via a click chemistry strategy to yield conjugates with precise 1:1 stoichiometry. Preliminary cytotoxicity studies of the targeted photosensitisers showed that both conjugates exhibited limited dark toxicity, and excellent cell killing in the HER2+ BT-474 cell line. Successful focal-point deprotection and azide functionalisation was carried out on a single porphyrin-dendron conjugate, with a successful model click reaction to an alkyne-functionalised sugar displaying the possibility of bioconjugation of porphyrindendron conjugates via a click methodology.
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Yukruk, Funda. "Water Soluble Green Perylenediimide (pdi) Dyes As Potential Sensitizers For Photodynamic Therapy." Phd thesis, METU, 2004. http://etd.lib.metu.edu.tr/upload/3/12605693/index.pdf.
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Photodynamic therapy has been established as one of the approaches for the treatment of various malignant tumors. While most of the reagents used for this purpose are porphyrin derivatives, there is a strong motivation for finding novel and better sensitizers.
Perylenediimides are known for their photo- and chemical stability, but they do not have absorptions in the red end of the visible spectrum. However, recently reported green perylenediimides which have dialkylamino substituents on the perylene core, provide an alternative. To that end, we have designed and synthesized novel green perylenediimides with remarkable water solubility at neutral pH and absorption peaks beyond 650 nm. We demonstrated that on red-light excitation, singlet oxygen trap 1,3-diphenyl-iso-benzofuran is rapidly degraded.
We also carried out cell culture experimentsan important parameter to be optimized for practical application as a novel photodynamic therapy agent was the excited dye toxicity to dark toxicity. Our results confirmed that these novel perylenediimides acted as sensitizers generating singlet oxygen and the initial in vitro biological experiments demonstrated their potential utility in photodynamic therapy.
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Sarfehnia, Arman. "Water calorimetry-based radiation dosimetry in iridium-192 brachytherapy and proton therapy." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:8881/R/?func=dbin-jump-full&object_id=92297.
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Frangville, Camille. "Functional water soluble polymers and metal ions interactions for diagnosis and therapy." Toulouse 3, 2015. http://www.theses.fr/2015TOU30378.
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Les polymères hydrosolubles fonctionnels regroupent une grande variété d'architectures telles que des polymères linéaires (homopolymères, copolymères à blocs. . . ), ou branchés (dendrimères, polymères hyperbranchés). Ces structures peuvent supporter des fonctions chimiques spécifiques, leur conférant ainsi des propriétés fonctionnelles telles que la biocompatibilité ou des états modulables par stimuli externes comme le pH ou la température. Ces polymères peuvent en outre comporter des fonctions ionisables ou être greffés de ligands permettant d'établir des interactions polymères -ion smétalliques. Ces travaux de thèse portent ainsi sur l'utilisation d'interactions ions - polymères hydrosolubles et fonctionnels dans le cadre de deux applications biomédicales distinctes que sont l'imagerie à résonance magnétique (IRM) pour le diagnostic et la thérapie liée à la maladie d'Alzheimer. Ces colloïdes dopés par des ions métalliques posent de nombreuses questions de physico-chimie mais permettent égalmeent d'élargir de manière considérable le champ des possibles. L'utilisation de mélanges d'ions métalliques pour atteindre des systèmes pour l'imagerie multimodale ou pour la théragnostique.
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Mårtensson, Lena. "Sterile water injections and acupuncture as treatment for labour pain /." Göteborg : Department of Obstetrics and Gynaecology, The Institute of Clinical Sciences, Sahlgrenska Academy at Göteborg University, 2006. http://hdl.handle.net/2077/703.
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Polin, Chris. "Water radiolysis nanoprocesses in the near vicinity of gold nanoparticles relevant to cancer therapy." Thesis, Queen's University Belfast, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709870.
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An improved tumour response to conventional radiotherapy has been observed when the mass has been doped with colloidal gold nanoparticles, with the hydroxyl radical implicated as the primary mediator. This thesis investigates the physical chemistry which drives this observed enhancement, focussing mainly on the quantification of hydroxyl radical production, and posits a new mechanistic pathway to account for it.
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Leiper, John Beattie. "Effects of the composition of solutions on water and solute absorption from the intact human intestine." Thesis, University of Aberdeen, 1997. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU100312.
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In a series of systematic studies using a steady-state jejunal perfusion technique the influence of carbohydrate content and type, osmolality and sodium concentration on jejunal absorption was investigated. Carbohydrate content over the range from 225 to 440 mmol glucosyl units.1-1 did not increase intestinal carbohydrate or water absorption. The type of carbohydrate used also appears to have little effect on the rates of water or solute absorption from moderately hypotonic carbohydrate-electrolyte solutions. Solutions which were moderately hypotonic with respect to normal human serum promoted faster rates of water absorption than isotonic, which in turn were faster than that from hypertonic solutions. Increased rates of solute absorption were associated with faster rates of water uptake from the hypotonic solutions. Sodium chloride concentration over the range 22 to 44 mmol.1-1 did not affect water or carbohydrate absorption, although sodium chloride uptake tended to be faster from the solutions with the higher electrolyte content. Measurement of net and unidirectional water fluxes suggests that the increase in net water absorption in segmental perfusion studies is due mainly to a decrease in mucosa-to-lumen water flux. The pattern of water uptake, as assessed by deuterium accumulation in the circulation, generally appeared to follow the pattern indicated by the combined effect of the measured rate of gastric emptying and segmented water intestinal absorption. In conclusion, intestinal perfusion studies have identified moderate hypotonicity as the major factor in determining the rate of water absorption and an important influence in regulating solute transport from carbohydrate-electrolyte solutions. Although there was a tendency for hypertonicity to be associated with faster rates of deuterium accumulation in the circulation, this model of assessing water uptake indicated that the sodium content of the ingested drink was also an important factor.
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Copteros, Athina. "Drawing on principles of Dance Movement Therapy practice in a South African water research context." Thesis, Rhodes University, 2017. http://hdl.handle.net/10962/50759.
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Research that draws on principles of Dance Movement Therapy in a South African water research context has not been done before. In order to initiate this exploration, culturally relevant themes from professional training in the United Kingdom were identified that could be developed in the context of trans-disciplinary water resource management research in South Africa. Hermeneutic phenomenology provided the methodological framing for this study. Interpretative Phenomenological Analysis was used to discover culturally relevant themes based on the recorded perceptions of the phenomenon of the training while it was taking place. The themes of: ‘awareness of power and difference'; ‘therapeutic adaptability'; ‘safety and ownership' and ‘connecting with the environment' emerged as overriding themes. Influences from Artistic Inquiry informed the inclusion of a creative embodied response to the themes that emerged. These themes then informed the application of some relevant principles of Dance Movement Therapy practice within a trans-disciplinary complex social-ecological systems researcher group. Eight members of the group participated in the study. They represented a range of academic research roles, genders and backgrounds. They reflected on their experience of an introductory session and five Dance Movement Therapy based sessions in semi-structured interviews. Using Interpretative Phenomenological Analysis, four themes were identified that capture the quality of the participants' shared experience of the phenomenon: ‘community engagement'; ‘embodiment'; ‘individual and group identity' and ‘integration'. Based on the integration of themes, it is concluded that principles of Dance Movement Therapy have a contribution to make. Core tenets of Dance Movement Therapy such as: inclusion of body and emotion; healing from trauma through embodiment; group processes held with safety and acceptance; and a deep level of connection to self, each other and the wider ecology, address some of the basic challenges of trans-disciplinary complex social ecological systems research practice. Through researchers experiencing principles of DMT practice for themselves and reflecting on their experience, it is possible that their embodied knowledge and reflections will influence and inform their engagement with communities in the future.
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Goel, Priya. "Quantitative assessment of glioma therapy effiicacy using magnetic resonance diffusion tensor imaging." Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2009r/goel.pdf.
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Thesis (M.S.)--University of Alabama at Birmingham, 2008.Additional advisors: Louis B. Nabors, James M. Markert, Donald B. Twieg. Description based on contents viewed July 8, 2009; title from PDF t.p. Includes bibliographical references (p. 73-79).
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Bajaj, Sahil, John R. Vanuk, Ryan Smith, Natalie S. Dailey, and William D. S. Killgore. "Blue-Light Therapy following Mild Traumatic Brain Injury: Effects on White Matter Water Diffusion in the Brain." FRONTIERS MEDIA SA, 2017. http://hdl.handle.net/10150/626295.
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Mild traumatic brain injury (mTBI) is a common and often inconspicuous wound that is frequently associated with chronic low-grade symptoms and cognitive dysfunction. Previous evidence suggests that daily blue wavelength light therapy may be effective at reducing fatigue and improving sleep in patients recovering from mTBI. However, the effects of light therapy on recovering brain structure remain unexplored. In this study, we analyzed white matter diffusion properties, including generalized fractional anisotropy, and the quantity of water diffusion in isotropic (i.e., isotropic diffusion) and anisotropic fashion (i.e., quantitative anisotropy, QA) for fibers crossing 11 brain areas known to be significantly affected following mTBI. Specifically, we investigated how 6 weeks of daily morning blue light exposure therapy (compared to an amber-light placebo condition) impacted changes in white matter diffusion in individuals with mTBI. We observed a significant impact of the blue light treatment (relative to the placebo) on the amount of water diffusion (QA) for multiple brain areas, including the corpus callosum, anterior corona radiata, and thalamus. Moreover, many of these changes were associated with improvements in sleep latency and delayed memory. These findings suggest that blue wavelength light exposure may serve as one of the potential non-pharmacological treatments for facilitating structural and functional recovery following mTBI; they also support the use of QA as a reliable neuro-biomarker for mTBI therapies.
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Brunt, Vienna. "Chronic passive heat therapy as a novel means of improving vascular function in sedentary humans." Thesis, University of Oregon, 2016. http://hdl.handle.net/1794/20556.
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Cardiovascular disease is the leading cause of death in the developed world. The majority of cardiovascular diseases are characterized by disorders of the arteries, predominantly caused by endothelial dysfunction and arterial stiffening. Passive heat stress results in elevations in core temperature (inducing heat shock protein expression) and changes in cardiovascular hemodynamics, such as increased cardiac output and shear stress, that are similar to exercise. Thus, repeated passive heat stress (“heat therapy”) may provide an alternative means of improving cardiovascular health, particularly for patients with limited exercise tolerance and/or capabilities. Therefore, the goal of this dissertation was to perform integrative studies to determine the effects of heat therapy on vascular function and the associated cellular pathways in young, sedentary humans.
Twenty subjects were assigned to participate in 8 weeks (4-5x/week) of heat therapy (N=10; immersion in a 40.5°C bath sufficient to maintain rectal temperature ≥38.5°C for 60 min/session) or thermoneutral water immersion (N=10; sham).
As discussed in Chapter V, we found that heat therapy improved numerous well-established biomarkers of conduit vessel/macrovascular function, including flow-mediated dilation (a measure of endothelial function), arterial stiffness, intima media thickness, and blood pressure. Heat therapy also improved microvascular function, as discussed in Chapter VI, measured as improved cutaneous thermal hyperemia and nitric oxide-dependent dilation (the difference between microdialysis sites receiving Lactated Ringer’s [control] and nitric oxide synthase inhibition). No changes were observed in any variables in sham subjects. In Chapter VII, we showed that both direct cellular heating and serum collected from human subjects following heat therapy improved nitric oxide bioavailability and angiogenesis in cultured endothelial cells, providing potential mechanisms by which heat therapy improves vascular function in vivo.
Therefore, the studies described herein provide comprehensive evidence that passive heat therapy improves vascular health and insight into the mechanisms involved. Our data presented in Chapters IV-VII, combined with pilot data we conducted in spinal cord injured individuals (Chapter VIII), strongly indicate that passive heat therapy could be used as a simple and effective tool to improve cardiovascular health in a variety of patient populations.
This dissertation includes published and unpublished co-authored material.
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Mackie, Emilie Ceschi. "Pseudoatrophyt of the brain in multiple sclerosis : the effect of therapy on T1 measures of brain water content." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/26182.
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Magnetic Resonance Imaging (MRI) measures of T₁ relaxation provide a sensitive and reproducible measure of water content in vivo. In the present study T₁ histograms were used to monitor changes in the brain water content of multiple sclerosis (MS) patients initiating Disease Modifying Therapies (DMT). The initiation of DMT, which target inflammation, is associated with a decrease in brain volume (BV) greater than would be expected by natural history alone. Reductions in BV may reflect worsening disease in untreated patients; however for patients treated with DMT, reductions in BV early in the treatment course may represent a clinical improvement due to initial anti-inflammatory effects of therapy and the resulting decrease in edema. The initial change in BV upon starting DMT is termed pseudoatrophy, a reversible decrease in BV due to a loss of water from the brain parenchyma. Patients with clinically definite MS planning on initiating DMT were recruited and scanned at two time points prior to initiating therapy and two time points after initiating therapy to determine the change in water content of the brain.
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Muli, Dominic Kyalo. "Synthesis and Evaluation of Asymmetric Zinc and Phosphorous Pc Photosensitizers for Mitochondrial Targeted Photodynamic Therapy." Diss., The University of Arizona, 2015. http://hdl.handle.net/10150/581326.
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Cancer remains a global pandemic and is rapidly overtaking other diseases as the no.1 killer in developing nations. Photodynamic therapy (PDT) has been advanced as a minimally invasive cancer therapy. In addition, the emergence of harmful microbes with increasing resistance to drugs has prompted the employment of photodynamic antimicrobial chemotherapy (PACT) as a promising alternative to combat antibiotic resistance. In PDT and PACT, a photosensitizer (dye/drug) upon activation by light transfers energy to molecular oxygen producing singlet oxygen which kills cells. There is increased attention and research into more selective and non-aggregated photosensitizers that will better PDT in treating cancer. This research work is focused on design and synthesis of non-aggregated asymmetric phthalocyanines (dyes) tagged with mitochondrial targeting vehicles to maximize selectivity and photo-killing of tumor cells. Chapter 1 presents a brief review of the current status of PDT and treatment of cancer. The three components of PDT namely, light, oxygen and the photosensitizer, are briefly discussed giving a concise overview of the development of each of them in bettering PDT as an alternative to cancer therapy. Chapter 2 outlines the design, synthesis and characterization of two non-aggregated symmetric ZnPc isomers that have improved water solubility due to incorporation of triethylene glycol groups. The extension of the max absorption to near-IR via non-peripheral substitution on the Pc macrocycle is reported, while comparing the photophysical characteristics of both isomers. Chapter 3 details the improved selectivity of photosensitizers by conjugating ZnPcs to rhodamine B, a delocalized lipophilic cation, which targets the mitochondria of the cell. This conjugation achieved 70% more cell death suggesting that incorporation of rhodamine improved cellular uptake and localization of the photosensitizers which is crucial. Chapters 4 and 5 cover the design, synthesis, characterization, and photodynamic therapy evaluation of ZnPc and phosphorous phthalocyanines. Introduction of phosphorous as an electron deficient central atom promoted a 42 nm bathochromic shift relative to the corresponding ZnPc isomer. Additionally, the effect of peripheral and non-peripheral substitution on phototoxicity of these new compounds is studied and reported. Chapter 5 also gives concluding remarks, and future directions of this work.
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Ververs, James. "A quantitative method for reproducible ionization chamber alignment to a water surface for external beam radiation therapy depth dose measurements." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/2600.
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Ionization chambers (ICs) are the most commonly used detectors for radiation therapy dose measurements. Typical IC measurements use cylindrical ICs in a water phantom and therefore require initial IC alignment to the water surface. This alignment has long been ignored and only recently has a qualitative governing recommendation been made. This thesis describes a reproducible methodology for quantitative ionization chamber water surface alignment. Depth-ionization measurements are taken with twenty-eight IC designs under varying conditions including, but not limited to, changes in scan direction, speed, and resolution, radiation beam type, field size, energy, and electron contamination. Measurements are acquired using standard radiotherapy accelerators in the Virginia Commonwealth University Department of Radiation Oncology and at the National Research Council of Canada, where a customized scanning system capable of better than 0.15 mm IC positioning precision is used. Measurements are also performed with standard commercial scanning equipment on the Accuray CyberKnife, a specialized radiosurgery-class accelerator. An analytical model is developed from basic principles to test the theoretical foundations of IC response near a water surface. The theoretical foundation is further validated via Monte Carlo simulation models that fully account for all details of the ICs used to take measurements. It is determined that the dose gradient as a function of depth is maximized when a given IC reaches the water surface when moving from depth in water. This effect is unchanged under all of the measurement scenarios tested. Measurements taken at 0.1 mm resolution for several seconds per point over several millimeters near the surface will yield a gradient peak that can be used for quantitative alignment. Using developed software, multiple scans at variant resolutions can be stitched into typical clinical scans so as not to significantly affect clinical measurement workflow. The recommended measurement method is developed in a format suitable for inclusion into a clinical protocol for depth-ionization measurement acquisition.
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Nguyen, Vo Thu An. "Magnetic polyion complex micelles as therapy and diagnostic agents." Thesis, Bordeaux, 2015. http://www.theses.fr/2015BORD0138/document.
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Ce manuscrit de thèse présente la synthèse de nanoparticules d’oxyde de fer superparamagnétiques couramment appelées SPIONs servant d’agents de contraste pour l’imagerie par résonance magnétique (IRM) et la génération de chaleur pour la thérapie cellulaire par hyperthermie induite par champ magnétique radiofréquence (HMRF). Le contrôle des tailles et de la distribution en tailles des SPIONs et donc de leurs propriétés magnétiques a été obtenu en utilisant un copolymère arborescent G1 (substrat de polystyrène branché en peigne noté G0, greffé avec des groupements pendants poly(2-vinyle pyridine) ) comme milieu « gabarit », tandis que la stabilité colloïdale et la biocompatibilité des SPIONs ont été apportées par un procédé de poly-complexation ionique grâce à un copolymère double-hydrophile acide polyacrylique-bloc-poly(acrylate de 2-hydroxyéthyle) PAA-b-PHEAThis Ph.D. dissertation describes the synthesis of superparamagnetic iron oxide nanoparticles (SPIONs) designed to serve as magnetic resonance imaging (MRI) contrast agents and for heat generation in cellular radiofrequency magnetic field hyperthermia (MFH) treatment. Control over the size and size distribution of the iron oxide nanoparticles (NPs), and thus over their magnetic properties, was achieved using a G1 arborescent copolymer (comb-branched (G0) polystyrene substrate grafted with poly(2-vinylpyridine) side chains, or G0PS-g-P2VP) as a template. Good colloidal stability and biocompatibility of the SPIONs were achieved via the formation of polyion complex (PIC) micelles with a poly(acrylic acid)-block-poly(2-hydroxyethyl acrylate) (PAA-b-PHEA) double-hydrophilic block copolymer
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Vilches, Freixas Gloria. "Dual-energy cone-beam CT for proton therapy." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSEI099/document.
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La proton thérapie est une modalité de traitement du cancer qu’utilise des faisceaux de protons. Les systèmes de planification de traitement actuels se basent sur une image de l’anatomie du patient acquise par tomodensitométrie. Le pouvoir d’arrêt des protons relatif à l’eau (Stopping Power Ratio en Anglais, SPR) est déterminé à partir des unités Hounsfield (Hounsfield Units en Anglais, HU) pour calculer la dose absorbée au patient. Les protons sont plus vulnérables que les photons aux modifications du SPR du tissu dans la direction du faisceau dues au mouvement, désalignement ou changements anatomiques. De plus, les inexactitudes survenues de la CT de planification et intrinsèques à la conversion HU-SPR contribuent énormément à l’incertitude de la portée des protons. Dans la pratique clinique, au volume de traitement s’ajoutent des marges de sécurité pour tenir en compte ces incertitudes en détriment de perdre la capacité d’épargner les tissus autour de la tumeur. L’usage de l’imagerie bi-énergie en proton thérapie a été proposé pour la première fois en 2009 pour mieux estimer le SPR du patient par rapport à l’imagerie mono-énergie. Le but de cette thèse est d’étudier la potentielle amélioration de l’estimation du SPR des protons en utilisant l’imagerie bi-énergie, pour ainsi réduire l’incertitude dans la prédiction de la portée des protons dans le patient. Cette thèse est appliquée à un nouveau système d’imagerie, l’Imaging Ring (IR), un scanner de tomodensitométrie conique (Cone-Beam CT en Anglais, CBCT) développé pour la radiothérapie guidée par l’image. L’IR est équipé d’une source de rayons X avec un système d’alternance rapide du voltage, synchronisé avec une roue contenant des filtres de différents matériaux que permet des acquisitions CBCT multi-énergie. La première contribution est une méthode pour calibrer les modèles de source et la réponse du détecteur pour être utilisés en simulations d’imagerie X. Deuxièmement, les recherches ont évalué les facteurs que peuvent avoir un impact sur les résultats du procès de décomposition bi-énergie, dès paramètres d’acquisition au post-traitement. Les deux domaines, image et basée en la projection, ont été minutieusement étudiés, avec un spéciale accent aux approches basés en la projection. Deux nouvelles bases de décomposition ont été proposées pour estimer le SPR, sans avoir besoin d’une variable intermédiaire comme le nombre atomique effectif. La dernière partie propose une estimation du SPR des fantômes de caractérisation tissulaire et d’un fantôme anthropomorphique à partir d’acquisitions avec l’IR. Il a été implémentée une correction du diffusé, et il a été proposée une routine pour interpoler linéairement les sinogrammes de basse et haute énergie des acquisitions bi-énergie pour pouvoir réaliser des décompositions en matériaux avec données réelles. Les valeurs réconstruits du SPR ont été comparées aux valeurs du SPR expérimentales déterminés avec un faisceau d’ions de carboneProton therapy is a promising radiation treatment modality that uses proton beams to treat cancer. Current treatment planning systems rely on an X-ray computed tomography (CT) image of the patient's anatomy to design the treatment plan. The proton stopping-power ratio relative to water (SPR) is derived from CT numbers (HU) to compute the absorbed dose in the patient. Protons are more vulnerable than photons to changes in tissue SPR in the beam direction caused by movement, misalignment or anatomical changes. In addition, inaccuracies arising from the planning CT and intrinsic to the HU-SPR conversion greatly contribute to the proton range uncertainty. In clinical practice, safety margins are added to the treatment volume to account for these uncertainties at the expense of losing organ-sparing capabilities. The use of dual-energy (DE) in proton therapy was first suggested in 2009 to better estimate the SPR with respect to single-energy X-ray imaging. The aim of this thesis work is to investigate the potential improvement in determining proton SPR using DE to reduce the uncertainty in predicting the proton range in the patient. This PhD work is applied to a new imaging device, the Imaging Ring (IR), which is a cone-beam CT (CBCT) scanner developed for image-guided radiotherapy (IGRT). The IR is equipped with a fast kV switching X-ray source, synchronized with a filter wheel, allowing for multi-energy CBCT imaging. The first contribution of this thesis is a method to calibrate a model for the X-ray source and the detector response to be used in X-ray image simulations. It has been validated experimentally on three CBCT scanners. Secondly, the investigations have evaluated the factors that have an impact on the outcome of the DE decomposition process, from the acquisition parameters to the post-processing. Both image- and projection-based decomposition domains have been thoroughly investigated, with special emphasis on projection-based approaches. Two novel DE decomposition bases have been proposed to estimate proton SPRs, without the need for an intermediate variable such as the effective atomic number. The last part of the thesis proposes an estimation of proton SPR maps of tissue characterization and anthropomorphic phantoms through DE-CBCT acquisitions with the IR. A correction for X-ray scattering has been implemented off-line, and a routine to linearly interpolate low-energy and high-energy sinograms from sequential and fast-switching DE acquisitions has been proposed to perform DE material decomposition in the projection domain with real data. DECT-derived SPR values have been compared with experimentally-determined SPR values in a carbon-ion beam
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Orlandini, Jacque. "Die effek van krioterapie op die akute herstel van universiteit-netbalspelers se onderbeenspiere / Jacque Orlandini." Thesis, North-West University, 2007. http://hdl.handle.net/10394/1829.
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In the last few years researchers have more and more focussed on the possible use of cryotherapy as an acute and long term recovery facilitating technique by sportsmen and women. Barnette (2006) did, however, state that research supporting cryotherapy as a recovery facilitating technique, is not convincing and that the majority of research show that it has a negative impact on the recovery of subjects after exercise. It is against this background that the aim of the study was firstly to critically analyse the available literature of the past fifteen years (1992-2007) with regard to the study subject; die nature of the cryotherapy technique that was used as well as the findings with regards to the effects of these types of techniques on a wide variety of physiological variables, physical and motor performance; secondly, to provide guidelines for the use of cryotherapy as a recovery facilitating technique and thirdly to determine the effect of cryotherapy on the acute recovery of University netball players' lower leg muscles in an isokinetic ankle exercise.
Firstly, it was shown that ice water immersion and ice pack application are the most common techniques that are used in cryotherapy studies. The results in the majority of articles indicated that cryotherapy had a non-significant acute effect on isokinetic, eccentric and concentric peak torque as well as time to reach peak torque and the angle at which the peak torque was reached; isometric, maximal and sub-maximal strength and accuracy of strength execution; normalized, average vertical ground reaction force as well as time of reaching peak power and vertical jump height; baseball pitching accuracy, proprioception, ankle joint range of movement, positioning and speed during execution of a movement; blood lactate removal and blood flow speed as well as muscle soreness after completion of an exercise. With regard to the long term effects of cryotherapy research showed that isotonic hand grip strength and endurance, plasma adrenaline, non-adrenaline, dopamine, renine, aldosterone, heart rate and blood pressure after 6 weeks; respiratory gas exchange ratio, heart rate, muscle glycogen concentration, plasma lactate, glucose and free fatty acids after 8 weeks or brachial artery cross-section and vascular endothelial growth factor after 4 weeks of exercise and cryotherapy did not experience any significant changes between the cryotherapy and control group. Other physical, motor performance and physiological variables did not show a certain trend with regards to the way they were affected by cryotherapy. In some cases variables were affected significantly negatively while the opposite was true in other cases where variables were significantly positively influenced.
With regard to the results of the study on the acute recovery of University netball players' lower leg muscles due to cryotherapy, it was found that the acute recovery of only four isokinetic variables were significantly influenced (p = 0.05) by cryotherapy, namely: left leg relative total dorsiflexion work, average peak dorsiflexion torque, right dorsiflexion and plantar flexion endurance. The acute recovery of the first mentioned strength endurance related variable was significantly negatively influenced by the cryotherapy. In contrast with this result the acute recovery of the three last mentioned isokinetic muscle relative peak torque and endurance related variables were significantly positively influenced by the cryotherapy.
The overall conclusion that can therefore be drawn from the above-mentioned results show that the majority of isokinetic plantar- and dorsiflexion torque variables (12 out of 16, 75%) as well as other physical, motor performance and physiological variables experience no significant effect with regards to acute and long term recovery due to cryotherapy.
The research did, however, show that the effectiveness of cryotherapy was influenced by the adiposity thickness, nature of the cryotherapy application, type of medium that was used for cryotherapy application and the length of time during which cryotherapy was applied. The recommendation for the use of cryotherapy as a recovery facilitating technique can be summarised as follows: the temperature of the cryotherapy medium that is used, must vary between 5°C and 10°C; the duration of cryotherapy between 15 and 20 minutes; the most general application area: for ice water immersion - immersed up until the level of the gluteal fold or crista ileac and the whole arm or forearm; for ice pack application - on the thigh, ankle and peripheral of the shoulder; the most common and effective ice pack application is direct on the skin surface by means of a bag filled with between 500 g and 1 500 g cubic formed ice. For long term use more that 2 consecutive days of cryotherapy application is recommended.Thesis (M.A. (Human Movement Science))--North-West University, Potchefstroom Campus, 2008.
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Bahrami, Amir. "Carbon nanotubes as near infrared laser susceptors." Thesis, University of Cambridge, 2011. https://www.repository.cam.ac.uk/handle/1810/230112.
Full textAbstract:
The coupling efficiency of carbon nanotubes with near infrared laser radiation at 940nm wavelength was investigated. Nanotubes treated with different post processing methods were irradiated at different laser power intensities as dry samples and suspensions in water or ethanol. The interaction with the laser beam was measured and quantified based on the temperature increase in the samples as well as the amount of energy transmitted through them. Parallel experiments using carbon black revealed better performance of carbon nanotubes in terms of coupling efficiency and heat dissipation to their surroundings. It was found that most of the incident radiation on an individual carbon nanotube is absorbed, resulting in extreme local temperature increases proportional to the laser intensity, which can lead to instant tube oxidation in air. Such high heats are efficiently transferred to the material in immediate contact with the nanotubes, increasing its temperature very rapidly. The most intriguing results were obtained in the presence of water where the observations suggested, disintegration of carbon nanotubes with each laser pulse. It is shown that extremely high local temperatures vaporise the water in the immediate vicinity of a carbon nanotube and result in a water-gas reaction. It is further postulated that such effects can be achieved with laser beams at power intensities near the skin tissue's safe exposure thresholds, and therefore can potentially be used as a method of removing nanotubes from living tissue. This has advantages in providing an exit route for nanotubes whether introduced on purpose for reasons of medicine or therapy, or possibly, as a result of inadvertent exposure. Further studies on laser heating and transmission through different dry samples, highlighted that more crystalline structures such as that of a heat-treated nanotube, are more effective in causing extinction of the laser beam and a reduction in the transmitted beam intensity, however the tubes with more defects or with a length comparable to the radiation wavelength are very effective in converting the absorbed laser energy to heat. This effect is exacerbated when the laser beam is polarised parallel to the long axis of the carbon nanotubes. These heating effects were exploited to create welds in high density polyethylene using through transmission laser welding. The resultant welds showed better than or equal mechanical performance to welds made using industrial absorbers such as carbon black or Clearweld®.
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Davin, Maureen Ann. "Music's effect on heart rate, ratings of perceived exertion, and affect of older women participating in water exercise." [Pensacola, Fla.] : University of West Florida, 2005. http://purl.fcla.edu/fcla/etd/WFE0000003.
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Rahmannejad, Hossein. "Verlaufsdiagnostische Untersuchung der Auswirkungen des therapeutischen Aqua-Jogging auf die Bewegungsmöglichkeiten bei chronischen Schmerzen im Lumbal-Bereich." Doctoral thesis, Universitätsbibliothek Leipzig, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-134567.
Full textAbstract:
In der Therapie orthopädischer Erkrankungen/Verletzungen gewann in den letzten Jahren das Training im Wasser als aktive Maßnahme an Bedeutung. Auf der Suche nach Möglichkeiten einer frühfunktionellen, aber schonenden Behandlung wurde das Bewegungstraining im Wasser wieder entdeckt (vgl. Froböse/ Nellessen/ Eckey 2003, 211-29).
Innenmoser (2007) betonte, dass therapeutisches Aqua-Jogging geeignet bzw. notwendig ist für Menschen mit Schädigungen, chronischen Krankheiten und mit Beeinträchtigungen bzw. Gefährdungen vor allem der körperlichen Funktionen, aber auch bei Schwächen des Stütz- u. Bewegungsapparats und chronischen Erkrankungen wie Rheuma, Wirbelsäulenschäden und auch bei „Low-Back-Pain“-Patienten.
Der Bewegungsraum Wasser bietet im Vergleich zu Bewegungen an Land, aufgrund seiner besonderen physikalischen Eigenschaften (vgl. hierzu alle zitiert in: Innenmoser 2001, 27: Aschoff 1971; Klauck 1977, 1998; Stegemann 1991; Stuart 2000 u.a.), eine weitestgehende Entlastung des Stütz- und Bewegungsapparates, insbesondere bei Teilnehmern mit stark verändertem Bewegungsbild. Für viele Menschen mit körperlichen Schädigungen sind bewegungstherapeutische Maßnahmen im Wasser die einzige Möglichkeit zur Erhaltung bzw. Steigerung ihrer Leistungsfähigkeit.
2 Ziele der vorliegenden Untersuchung
Ziel der vorliegenden Untersuchung ist es, die möglichen Wirkungen der Aktiven Wassertherapie in Form des therapeutischen Aqua-Jogging nach dem Konzept Innenmoser (2001) bei „chronischen“ Rückenschmerz- Patienten nachzuweisen.
Weil in sportwissenschaftlichen Studien die in klinischen Studien üblichen medizinischen Kontrollverfahren (Röntgendiagnostik, Oberflächen- EMG usw.) nicht zur Anwendung kommen können, wird in dieser Studie versucht, die Wirkungen der „ Bewegungstherapie im Wasser“ über den Weg eines indirekten Schließverfahrens zu ermitteln. Dieses beruht darauf, dass die Wirkungen der Aktiven Wassertherapie sich in einer verbesserten Bewegungsmöglichkeit bzw. einem höheren Bewegungsausmaß der Bewegungen des Rumpfes bzw. der unteren Wirbelsäule dann zeigen, wenn die Personen unmittelbar nach Verlassen des Wassers mit unserem ultraschallgestützten Prüfverfahren kontrolliert werden. Der Vergleich zwischen den Veränderungen der Messwerte bei ausgesuchten Bewegungsaufgaben / Tests im Bereich der Wirbelsäule vor Beginn des Aqua-Joggens und unmittelbar danach wird als Indikator für eine bessernde Wirkung der Bewegungen im Wasser angesehen. Dabei galt es nachzuweisen, dass tatsächlich die Kontrolle am Beckenrand deutlichere Zeichen einer Wirkung der Bewegungen im Wasser erbringen kann, als die zeitlich immer viel später liegenden Laboruntersuchungen.
3 Methodik und Design
In einer kontrollierten prospektiven Studie wurden 11 Probanden im Alter zwischen 41 und 71 Lebensjahren mit chronischen Rückenschmerzen in der Lendenwirbelsäule (Dauer > 2 Jahre) in Rahmen einer Einzelfallstudie (ohne begleitende physiotherapeutische Behandlung) erfasst. Sie nahmen über die Dauer von 14 Wochen ein mal pro Woche an einem Aqua-Jogging-Programm von 60 min Dauer teil. Alle Probanden absolvierten das Trainingsprogramm ausschließlich im Wasser. Neben den Messungen von Mobilität und Schmerz wurden durch Prä-, Post-, Follow-up-Tests und die verlaufsdiagnostische Untersuchung mit Hilfe eines „Befindlichkeitsfragebogens“, auch die subjektiven Einschätzungen von Leistungsfähigkeit, Befinden und Schmerzempfinden ermittelt. Im Labor kamen als ergänzende Parameter die Ermittlung der statischen Körperhaltung und der anthropometrischen Date hinzu. Der alltäglich wechselnde Schmerzzustand der Probanden wurde anhand eines „Tagebuchs“ festgehalten. Die Lendenwirbelsäule-Mobilität wurde mit Hilfe der Bestimmung des „Schoberzeichens“ im Labor in die Analyse mit einbezogen. Die Schmerzvarianten der Personen wurde mit Hilfe einer Befragung (Fragebogen FSR), dem ein Schmerzregulationsmodell zugrunde liegt, am Anfang und am Ende des Aqua-Jogging-Programms und nach dessen Ende im Follow-Up Zeitraum gemessen.
Wichtigste Aufgabe aber waren die Messungen der Bewegungsmöglichkeiten der Lendenwirbelsäule mit Hilfe des Ultraschallmessverfahrens System Zebris am Beckenrand vor und nach dem Aqua-Jogging und dessen Auswertung unter Berücksichtung jedes einzelnen Probanden.
4 Ergebnisse
Die Auswertung der Veränderungen mit dem ultraschalltopografischen Messverfahren nach Zebris in den Verlaufsuntersuchungen ergab bei 8 Probanden eine Verbesserung der LWS Beweglichkeit. Bei 8 Probanden waren auch Verbesserungen im Follow-Up Test im Merkmal Flexion zu sehen. Diese fiel deutlich umfangreicher aus. Bei weiteren 6 Probanden ergaben sich Verbesserungen der Extension im Bereich der LWS. Ebenfalls 6 Probanden konnten die Lateralflexion nach links vergrößern. Nur bei 5 Probanden verbesserte sich die Lateralflexion nach rechts. Bei 5 Probanden war die Rotation nach links besser, während bei 8 Probanden die Rotation nach rechts besser gelang.
6 Probanden verbesserten ihre LWS Beweglichkeit in der Flexion, wenn man das Schoberzeichen als Kriterium heranzog.
Nur 3 Probanden verbesserten ihre FSR- Kompetenz, während 5 Probanden eine geringere Schmerzintensität lt. FSR aufwiesen. 7 Probanden zeigten eine geringere Angst gemäß FSR und bei 7 Probanden verringerte sich die Neigung zu Depression, Die Effekte sind unabhängig von Geschlecht und Chronifizierungsausmaß.
Verallgemeinernd gesehen waren mit Hilfe der ausgewählten Messkriterien eine Verbesserung der Beweglichkeit der Wirbelsäule, eine Linderung der Schmerzen und Steigerung der Lebensqualität zu beobachten. Trainingsbedingt zeigte sich teilweise eine kräftige Beschwerdereduktion (Linderung der Schmerzintensität) und eine relativ deutliche Steigerung der körperlichen Leistungsfähigkeit. Teilnehmer über 60 Jahre zeigen gegenüber jüngeren Teilnehmern einen höheren Beweglichkeitszuwachs der Flexion bei gleicher Schmerzreduktion.
Es wurde eindeutig klar, dass die individuell unterschiedlichen Wirkungen des Aqua-Joggings auf Flexion, Extension, Lateralflexion links und rechts und Rotation links und rechts nur dann sicher erfasst werden können, wenn die Kontrolle tatsächlich am Beckenrand erfolgte. Diese akuten Wirkungen erklärten auch das fast stets gesteigerte Gefühl des Wohlbefindens bei den Probanden und ihre regelmäßig geäußerten Wünsche nach einer Fortsetzung der Trainingsmaßnahmen
5 Schlussfolgerungen
Das Aqua-Jogging bestätigte sich als wirksame Maßnahme im Sinne einer Trainingstherapie. In der untersuchten Stichprobe wurden schon nach kurzer Zeit und im Verlauf der Studie bis zum Ende deutliche positive Veränderungen der Bewegungsmöglichkeiten der Lendenwirbelsäule festgestellt. Dass dies nicht bei allen Probanden bei allen Provokation einheitlich gleich war, lässt sich erklären durch die sehr unterschiedlichen Ausprägungen der Symptome, obwohl alle sicher zur Gruppe der „Low-Back-Pain“-Patienten zu zählen sind. Die Ergebnisse der Untersuchungen und die Durchführung des Trainings unter den festgelegten Bedingungen können weitere Erkenntnisse für effektive Therapiemaßnahmen für Rückenpatienten bringen.
6 Schlussthesen
6.1 Mit Hilfe des Ultraschall-Diagnoseverfahrens (System Zebris) am Beckenrand gelingt es, die unmittelbaren Auswirkungen des Aqua Joggings – repräsentiert durch eine verbesserte Beweglichkeit in Flexion, Extension, Lateralflexion und Rotation der LWS – nach jeder Therapieeinheit nachzuweisen.
6.2 Ein erhöhtes Niveau der Lendenwirbelsäulen–Bewegungsmöglichkeiten und eine Verbesserung der „Schmerzfaktoren“ kann durch ein spezifisches Aqua-Jogging Training erreicht werden. Eine längerfristige Wirksamkeit der Intervention in Form von geringeren Rückbildungsprozessen auf den alten Zustand vor Beginn des Programms konnte am Follow-up-Messzeitpunkt nur teilweise gezeigt werden.
6.3 Alle Teilnehmer der Studie reagierten beim Post Test im Vergleich mit dem Prä-Test – im Sinne der Schmerzreduktion – positiv auf die Teilnahme am Aqua-Jogging. Die Patienten fühlten sich nach dem Aqua Jogging wohler als vor dem Aqua-Jogging.
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Veldsman, Lizl. "The impact of intravenous fluid and electrolyte administration on total fluid, electrolyte and energy intake in critically ill adult patients." Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/85659.
Full textAbstract:
Thesis (MNutr)--Stellenbosch University, 2013.ENGLISH ABSTRACT: Objectives: The objectives of this study were to determine the nutritional content/ contribution of intravenous (IV) fluid and electrolyte administration on the total feeding prescription of intensive care unit (ICU) patients. Methods: Retrospective review of ICU charts of consecutive patients (>18 years) with APACHE II scores ≥10 and on ≥72 hours nutrition therapy (NT) admitted to a medical/surgical ICU. Total fluid, electrolyte, energy and macronutrient intake from nutritional and non-nutritional sources were reviewed from ICU admission until discharge, discontinuation of NT or death for ≤7 days. Energy and protein delivery were compared to calculated targets of 25.4 – 28.6kCal/kg and 1.3 – 1.5g/kg respectively. Summary statistics, correlation coefficients and appropriate analysis of variance were used to describe and analyse the data. Results: A total of 71 patients (49% male), average age 49.2 ± 17.1, average APACHE II score 21.0 ± 6.1, 68% medical and 32% surgical, were included. Fluid and nutrient intake were reviewed over a mean of 5.7 ± 1.1 days. Mean daily fluid delivery was 3.2 ± 0.6L. IV fluid therapy (IVFT) contributed 32.0 ± 12.0% to total fluid delivery (TFD), whereas IV drug administration, including fluids used for reconstitution and dilution purposes, contributed 20.7 ± 8.1% to TFD. Balanced electrolyte solutions (BES) were the crystalloid of choice, prescribed in 91.5% of patients with a mean daily volume (MDV) of 0.5 ± 0.4L. Hypertonic low molecular weight (LMW) 130/0.4kD hydroxyethyl starch (HES) was the colloid of choice, prescribed in 78.9% of patients with a MDV of 0.2 ± 0.1L. Potassium salts were the most frequently prescribed IV electrolyte supplement (IVES), prescribed in 91% of patients (±20 – 60mmol per administration). NT was initiated within 14.5 ± 14.1 hours. The majority (80%) received enteral nutrition (EN). The mean daily energy delivered was 1613 ± 380kCal (25.1kCal/kg), meeting 93.6 ± 17.7% of mean target range (MTR). Mean daily protein delivery (PD) was 72 ± 22g (1.1g/kg), meeting 82.8 ± 19.9% of MTR. Non-nutritional energy sources (NNES), mostly derived from carbohydrate-containing IV fluids, contributed 10.1 ± 7.5% to total energy delivered (156kCal/d). Mean cumulative energy and protein balance was -674.0 ± 1866.1kCal and -86.0 ± 106.9g respectively. The majority (73%) received >90% of the minimum energy target but only 49% >90% of minimum protein target; 59% of those with energy intake 90-110% of target had adequate protein intake. A significant negative correlation was found between cumulative energy/protein balance and the time to initiation of NT (energy: r=-0.28, p=0.02; protein: r=-0.32, p=0.01). Conclusion: In this ICU BES are the crystalloid of choice and hypertonic LMW 130/0.4kD HES the colloid of choice for IVFT. Potassium salts are the most frequently prescribed IVES. NNES added significantly to energy delivery and should be included in the calculation of feeding prescriptions to avoid the harmful effects of overfeeding. Early initiation of EN with conventional products which are energy rich is insufficient to achieve adequate PD. EN formulae with a more favorable nitrogen to non-protein energy ratio could help to optimise PD during the first week of ICU care.
AFRIKAANSE OPSOMMING: Doelwitte: Die doelwit van hierdie studie was om die voedingswaarde/ bydrae van intraveneuse (IV) vog en elektroliet toediening tot die totale voedings voorskrif van pasiënte in ‘n intensiewe sorg eenheid (ISE) te bepaal. Metodes: Retrospektiewe bestudering van die ISE kaarte van agtereenvolgende pasiënte (>18 jaar) opgeneem in ‘n mediese/chirurgie ISE en met APACHE II tellings ≥10 en ≥72 ure voedingsterapie (VT). Totale vog, elektroliet, energie en makronutriënt inname vanaf voedingsverwante en nie-voedingsverwante bronne is vanaf ISE opname tot en met ontslag, staking van VT of sterfte, vir ≤7 dae hersien. Energie en proteiën inname is vergelyk met berekende doelwitte van 25.4 – 28.6kKal/kg en 1.3 – 1.5g/kg onderskeidelik. Beskrywende statisitiek, korrelasie koeffisiënte en toepaslike analises van variansie is gebruik vir data analise. Resultate: 71 pasiënte (49% mans), gemiddelde ouderdom 49.2 ± 17.1, gemiddelde APACHE II telling 21.0 ± 6.1, 68% medies en 32% chirurgie, is ingesluit. Vog en voedingstof inname is hersien oor ‘n gemiddelde tydperk van 5.7 ± 1.1 dae. Gemiddelde vog inname was 3.2 ± 0.6L/dag. IV vog terapie (IVVT) het 32.0 ± 12.0% bygedra tot totale vog inname (TVI). IV medikasie toediening, insluitende die herkonstruksie en verwatering van medikasie, het 20.7 ± 8.1% bygedra tot TVI. Die mees voorgeskrewe kristalloiëd en kolloiëd vir IVVT was gebalanseerde elektroliet oplossings (GEO), voorgeskryf in 91.5% van pasiënte (gemiddeld 0.5 ± 0.4L/dag), en hipertoniese lae molekulêre gewig (LMG) 130/0.4kD hidroksie-etiel stysel (HES), voorgeskryf in 78.9% van pasiënte (gemiddeld 0.2 ± 0.1L/dag), onderskeidelik. Die mees voorgeskrewe IV elektroliet supplement was kalium soute, voorgeskryf in 91% van pasiënte (±20 – 60 mmol per toediening). VT is binne 14.5 ± 14.1 ure geinisieër. Die meerderheid (80%) het enterale voeding (EV) ontvang. Die gemiddelde daaglikse energie inname van 1613 ± 380kCal (25.1kKal/kg) het 93.6 ± 17.7% van die gemiddelde doelwit rykwydte (GDR) bereik. Die gemiddelde daaglikse proteiën inname van 72 ± 22g (1.1g/kg) het 82.8 ± 19.9% van die GDR bereik. Nie voedings-verwante energie bronne (NVEB), meestal vanaf koolhidraat-bevattende IV vloeistowwe, het 10.1 ± 7.5% tot totale energie inname (TEI) bygedra (156kKal/d). Die gemiddelde kumulatiewe energie en proteiën balans was -674.0 ± 1866.1kKal en -86.0 ± 106.9g onderskeidelik. Die meerderheid (73%) het >90% van die minimum energie doelwit (ED) bereik. Slegs 49% het >90% van die minimum proteiën doelwit (PD) bereik. Opsomming: Die kristalloiëd en kolloiëd van keuse vir IVT is GEO en hipertoniese LMG 130/0.4kD HES onderskeidelik. Kalium soute word mees algemeen voorgeskryf. NVEB dra beduidend by tot TEI en moet inaggeneem word tydens die berekening van voedingsvoorskrifte ten einde oorvoeding te voorkom. Vroeë inisiëring van EV met konvensionele energie-ryke EV produkte is onvoldoende om genoegsame proteiën inname te verseker. EV produkte met ‘n gunstiger stikstof tot nie-proteiën energie verhouding sal help om proteiën inname gedurende die eerste week van intensiewe sorg te optimaliseer.Slegs 59% van pasiënte met genoegsame energie inname (90-110% van ED) het hul minimum PD bereik. Daar was ‘n beduidende negatiewe korrelasie tussen kumulatiewe energie/proteiën balans en die tyd tot inisiëring van VT (energie: r=-0.28, p=0.02; proteiën: r=-0.32, p= 0.01).
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White, Jerry R. (Jerry Robert) 1959. "Conceptual engineering designs for a mechanical shutter, a medical room door, and a water shutter for a fission converter-based boron neutron capture therapy medical facility." Thesis, Massachusetts Institute of Technology, 1999. http://hdl.handle.net/1721.1/80043.
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Butkutė, Jolanta. "Skirtingų kineziterapijos metodikų vandenyje įtaka radikulopatiniam juosmens skausmui." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2008. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2008~D_20080618_125427-79877.
Full textAbstract:
Šiame darbe tirta skirtingų kineziterapijos metodikų vandenyje įtaka radikulopatiniam juosmens skausmui.
Juosmeninės stuburo dalies struktūrinių ir funkcinių pakitimų sukeltas skausmas – tai multifaktorinė patologija, dėl kurios gydymo vieningos nuomonės kol kas nėra. Šiuo metu pagrindinė medicinos užduotis – efektyviai kontroliuoti skausmą ir kuo greičiau grąžinti sutrikusias funkcijas, kad žmogus vėl būtų darbingas. Tokios užduoties įgyvendinimui pasitelkiamos įvairios priemonės, nuo medikamentų iki chirurginių intervencijų.
Pastaruoju metu išskirtinis dėmesys skiriamas reabilitacijai, pabrėžiant kineziterapijos svarbą. Moksliniuose straipsniuose vyrauja nuomonė, kad ypa����� efektyvi gydant patologinių stuburo pakitimų sukeltą skausmą yra kineziterapija vandenyje. Juose minimos įvairios vandenyje naudojamos metodikos, tačiau tiek užsienio, tiek lietuvių autorių šaltiniuose nebuvo išskirtinai pabrėžiamas vienos ar kitos metodikos pranašumas.
Šio darbo tikslas – nustatyti tempimo-atsipalaidavimo ir stabilumo-jėgos pratimų įtaką radikulopatiniam juosmens skausmui. Tyrimo metu buvo vertinama skirtingų metodikų įtaka pacientų funkciniam pajėgumui, bei tiesios kojos kėlimo testo rezultatams. Taip pat stebimas trumpalaikis ir ilgalaikis kineziterapijos vandenyje poveikis radikulopatiniam juosmens skausmui.
Pagal pradinę hipotezę buvo manoma, kad tempimo-atsipalaidavimo pratimai turėtų labiau įtakoti radikulopatinį juosmens skausmą negu stabilumo-jėgos pratimai.
Atlikus... [toliau žr. visą tekstą]This paper describes research of different aquatic physiotherapy programs on the low back pain with radiculopathy. The pain of low back that is induced by structural and functional changes is multifactorial pathology that doesn’t have a unique treatment opinion. Nowadays the main task of medicine is to control the pain effectively and to restore disordered functions. In order to realize such task different treatment means are invoked, such as medicaments, surgery and etc. Nowadays preferential treatment is appointed to rehabilitation, especially physiotherapy. The dominant research opinion proposes that physical therapy in the water is very effective treatment of the pathological low back pain. It is mentioned a lot of methods used in the water, but there isn’t excluded any advantages of one or another method. The main task of this research is to define the influence of two different physical therapy methods in water to the low back pain with radiculopathy. There is estimated influence of different physical therapy methods to the functional ability and straight leg test results. There is also observed short-term and long-term physical therapy influence to the low back pain with radiculopathy. In primary hypothesis there is considered that stretching-relaxing exercises should have more impact for low back pain than stability–strength exercises. The result of the research showed that both physical therapy methods are effective in the low back pain treatment. Significant... [to full text]
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Rubelli, Alessia. "“L’idrokinesi nella gestione del linfedema secondario a carcinoma mammario: revisione sistematica della letteratura”." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amslaurea.unibo.it/21916/.
Full textAbstract:
Background
Il linfedema secondario a carcinoma mammario è una complicanza molto frequente. Il trattamento gold standard è la complessa terapia decongestionante. L’idrokinesi, in persone con carcinomi o in seguito ad operazioni chirurgiche per tumori,
viene utilizzata per la gestione della fatigue, tuttavia, nella terapia per il linfedema secondario a carcinoma mammario è spesso indicata come terapia di supporto.
Obiettivo
Valutare l’efficacia dell’idrokinesi nella gestione del linfedema secondario a carcinoma mammario, in termini di contributo nella diminuzione dell’edema, riduzione del
dolore e qualità della vita, sicurezza del trattamento, recupero ed aumento dell’articolarità.
Materiali e metodi
E’ stato seguito il PRISMA STATEMENT. Sono stati inclusi nella
revisione trials clinici controllati. I trials considerati esaminano popolazioni di donne affette da linfedema secondario a intervento chirurgico per carcinoma mammario, non è stato
imposto un limite di età o un intervento chirurgico specifico. La ricerca è stata condotta da un singolo esaminatore, consultando le banche dati di Pubmed, Cochrane, PEDro e UpToDate.
Risultati I risultati derivano dall’analisi di tre trials 41,42,43 e portano a delle conclusioni concordi, se pur con qualche variazione da studio a studio. Due studi su tre non hanno
evidenziato miglioramenti significativi in merito alla riduzione dell’edema. L’articolarità è stata valutata solo in due studi su tre, con risultati discordanti. I restanti outcomes (qualità
della vita, aderenza al trattamento e sicurezza del trattamento), hanno ottenuto in tutti e tre gli studi risultati o neutri o positivi.
Conclusioni
L’ idrokinesi nella donna operata di carcinoma mammario che ha sviluppato linfedema si è dimostrata utile. Con le conoscenze di oggi e i risultati ottenuti da questa revisione, l’idrokinesi non può sostituire la terapia classica (complessa terapia decongestionante),ma è consigliabile come terapia di supporto e accompagnamento.
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Kucukturhan, Aysu. "Bioactive Agent Carrying Plga Nanoparticles In Thetreatment Of Skin Diseases." Master's thesis, METU, 2012. http://etd.lib.metu.edu.tr/upload/12614551/index.pdf.
Full textAbstract:
The aim of this study was to develop drug delivery system based on poly(lactic acid-co-glycolic acid) (PLGA) nanoparticles (NPs) to achieve personalized treatment of selected skin disorders, like photo-aging, psoriasis and
atopic dermatitis. Dead Sea Water (DSW) and Retinyl Palmitate (RP) were used as active agents and they were loaded in PLGA NPs prepared either as spheres or capsules by o/w or w/o/w methods. MgCl2 and bovine serum albumin (BSA)
served as model active compounds. The diameter of the NPs was found to be in the range of 280 - 550 nm. The entrapment efficiency (E.E.) was less than 1% for RP, DSW and MgCl2, and 41% for BSA. Loading of Cl- together with BSA doubled the E.E. value of Cl- . In situ release studies showed a burst in the first day and more than 85% of
the chloride content was released within a week. When the macromolecule BSA was encapsulated, a much slower and triphasic release profile was observed which continued for up to 80 days. In vitro tests were performed using L929 fibroblast cells. Results of MTT
(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) test revealed that none of the NPs were cytotoxic. Additionally, all particles were hemocompatible
with hemolytic activity <1.5%. L929 fibroblast and Saos 2 human osteosarcoma cells were used to study the uptake of NPs by the cells. Particles accumulate near the nucleus. The characterization and cell viability tests, and drug release behavior indicate the suitability of these NPs for further testing to develop a patient specific skin diseases treatment approach.
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Ferreira, Marina Beloti. "Efeito na reparação óssea periapical da ozonioterapia como coadjuvante ao tratamento endodôntico. Estudo clínico-radiográfico." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/23/23145/tde-11092012-131848/.
Full textAbstract:
A reparação dos tecidos periapicais testemunha o êxito da terapia endodôntica. Por intervir de forma favorável na reparação tecidual, a ozonioterapia é reconhecida como um importante coadjuvante ao protocolo terapêutico, sendo oportuno verificar sua eficácia no caso da terapia endodôntica. Para isso, foi avaliada, in vivo a influência do gás ozônio, da água ozonizada e óleo ozonizado na reparação tecidual em situações de necrose pulpar com alterações ósseas periapicais, diagnosticado e caracterizado como quadros de infecção primária. Foram feitas radiografias previamente e ao final do tratamento e novamente no terceiro e no sexto mês após a conclusão da terapia endodôntica. Respeitando-se os critérios de inclusão, 36 pacientes da Clínica Odontológica da Faculdade de Odontologia da Universidade de São Paulo foram divididos aleatoriamente em 3 grupos: Grupo I (12 dentes) Controle: tratamento endodôntico segundo protocolo da Disciplina de Endodontia da FOUSP; Grupo II (12 dentes) protocolo terapêutico empregado pelo Grupo I e associado ao final com irrigação de 10 mL de água bidestilada ozonizada na concentração de 8 g/mL; e, Grupo III (12 dentes) protocolo terapêutico empregado pelo Grupo I e associado ao final do preparo do canal da aplicação de 10 mL do gás ozônio na concentração de 40 g/mL. Foi utilizado como medicação intracanal o hidróxido de cálcio veiculado em PRP no Grupo I e o óleo de girassol ozonizado (Philozon, Santa Catarina, SC, Brasil) nos Grupos II e III. As medicações permaneceram por um período de 15 dias e em seguida foi feita obturação com cimento AH-Plus. A avaliação da reparação óssea periapical foi realizada analisando as radiografias digitalizadas no programa ImageLab. Após a delimitação e quantificação de pixels das lesões periapicais, as radiografias finais e controles de 3 e 6 meses foram comparadas, indicando o quanto de redução da radiolucência periapical. Paralelamente, foi feita a análise de sensibilidade pós-operatória utilizando uma Escala Visual Analógica. Os pacientes foram questionados com relação à sensibilidade previamente ao início do tratamento, 72 horas após consulta inicial e nos controles de 3 e 6 meses, devendo associá-la com uma nota de 0 a 10 de acordo com a intensidade. Os dados foram submetidos à análise de variância, complementado pelo teste de Tukey, com significância de 5%. Os três protocolos terapêuticos instituídos promoveram redução da imagem radiolúcida periapical sem diferença estatística significante. Na análise da sensibilidade, o Grupo III apresentou os melhores resultados, com diferença estatística significante em relação aos demais grupos. Com base nos dados obtidos e na análise estatística executada, foi possível concluir que a ozonioterapia, por meio do emprego do gás ozônio e água ozonizada na fase do preparo químico cirúrgico e do óleo ozonizado como medicação intracanal, interviu de maneira favorável na reparação, em situações de necrose pulpar com alterações ósseas periapicais, sendo o gás mais efetivo que a água ozonizada, com diferenças estatísticas significantes. Os 2 grupos experimentais de ozonioterapia comparado ao grupo controle (protocolo FOUSP) apresentaram padrão de reparação óssea semelhante. A utilização da água ozonizada como irrigante e do óleo ozonizado como medicação intracanal mostrou a melhor eficácia do ponto de vista sintomatológico.The success of the endodontic treatment is related to the repair of the periapical tissues. The ozone therapy is known for its therapeutic usefulness, favorable tissue healing, thus it seems suitable for evaluating its efficiency in the endodontic therapy. The aim of this study was to evaluate in vivo the influence of ozone gas, ozonated water and oil in bone repair in cases of pulpar necrosis with radiographic evidence of periapical bone loss associated with primary endodontic infection. Radiographs (Xrays) were taken prior and after the completion of the endodontic treatment, three and six months later. According to the enclosure criteria, 36 patients of the Dental Clinic of the School of Dentistry, University of Sao Paulo, were selected and randomly divided in three groups: Group I (12 teeth) Control: endodontic treatment protocol according to the discipline of Endodontics FOUSP, Group II (12 teeth): endodontic protocol associated with final irrigation with 10 mL of bidestilated ozonated water at concentration of 8 g/mL and Group III (12 teeth): endodontic protocol associated with application of 10 mL of ozone gas at concentration of 40 g/mL. Calcium Hydroxide was used as intracanal medication for 15 days. In Group I it was associated with anesthetic solution and in the Groups II and III associated with ozonated oil (Philozon, Santa Catarina, SC, Brazil). After this period, all teeth were obturated with AH-Plus root canal sealer. Evaluation of periapical bone repair was performed with Image Lab software after image digitalization. After delimitation and pixel quantification of the periapical lesion area of the images immediately after the endodontic treatment, 3 and 6-months follow up, the obtained data were compared indicating the quantum reduction of the periapical radiolucency. In parallel, a postoperative sensitivity analysis was performed using a Visual Analog Scale. Patients were asked to score the sensitivity from 0 to 10 according to its intensity prior to first appointment, 72 hours later the first visit, 3 and 6 months later. Data were submitted to analysis of variance (ANOVA), complemented by the Tukey test at 5% of significance. All the three groups promoted a reduction of the apical radiolucent image without statistical difference. In the sensitivity analysis, Group III showed the best results with statistically significant difference compared to the other groups. Based on the statistical data analysis we concluded that ozone therapy through the use of ozone gas and ozonated water during the root canal instrumentation and ozonated oil as intracanal medication, positively intervene in the repair of periapical bone loss. The ozone gas was more effective than the ozonated water with significant statistical difference. Group II and III (experimental groups) compared to Group I (endodontic protocol FOUSP) showed a similar pattern of bone repair. The use of ozonated water as irrigant and ozonated oil as intracanal dressing showed better efficacy in terms of symptomatology.
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Miqueo, Evangelina. "Desempenho, mortalidade e escore fecal de bezerros aleitados com diferentes dietas líquidas e terapias de reidratação quando acometidos por diarreias." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/11/11139/tde-07062016-183238/.
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O objetivo deste trabalho foi avaliar o efeito da utilização de sucedâneo lácteo com alto conteúdo proteico de origem vegetal no desempenho e saúde de bezerros, e avaliar métodos de reidratação para o tratamento de diarreias. No primeiro estudo foram utilizados 33 bezerros da raça Holandês distribuídos nos tratamentos: 1) Alto volume e baixa proteína (AV/BP): 8 litros, 21,4% PB; 2) Alto volume e alta proteína (AV/AP): 8 litros, 23,7% PB e 3) Baixo volume e alta proteína (BV/AP): 6 litros, 23,7% PB. Os bezerros foram alojados em abrigos individuais, com livre acesso a água e concentrado. Não houve efeito dos tratamentos para o desempenho animal (P>0,05). Os tratamentos AV/BP e AV/AP resultaram em maior consumo de sucedâneo (P<0,05), mas não afetaram o consumo de concentrado nem o consumo total (P>0,05). O escore fecal foi maior (P>0,05) para animais nos tratamentos AV/AP e BV/AP. Os animais nos tratamentos AV/BP permaneceram maior número de dias em diarreia (P<0,05), em comparação aqueles aleitados com BV/AP, os quais tiveram menos dias com vida (P<0,05). A concentração de lactato foi maior (P<0,05) para animais nos tratamentos AV/BP e AV/AP enquanto a concentração de proteína total foi maior (P<0,05) nos tratamentos AV/BP e BV/AP. Sucedâneos com elevado conteúdo de proteína de origem vegetal afetam negativamente o desempenho de bezerros podendo levar o animal a morte. No segundo estudo foram comparados três soluções de hidratação oral quanto a sua eficiência em repor eletrólitos e água, além de manter o desempenho de bezerros. Foram utilizados 42 bezerros mestiços Holandês-Jersey, distribuídos nos tratamentos: 1) Soro comum, 2) Glutellac® e 3) Soro comum + Aminogut®. Os animais foram aleitados com 4 L/d de sucedâneo lácteo até a oitava semana de vida quando foram desaleitados de forma abrupta. As terapias de reidratação foram oferecidas quando os animais apresentavam escore fecal >= 3 na escala de 1 a 5. Não houve efeito das terapias de reidratação no desempenho nem em metabólitos sanguíneos (P>0,05). O consumo voluntário de água foi maior para os animais reidratados com Glutellac®, mas o consumo total maior para os animais reidratados com Soro comum. As concentrações de HCO3 e Na+ foram maiores para os animais no tratamento Glutellac® (P=0,088 e P=0,073 respectivamente), sendo a concentração de glicose também afetada pelo protocolo de hidratação (P<0,05). A concentração de HCO3 aumentou do primeiro para o segundo dia, a de K+ e glicose diminuíram do primeiro para o segundo dia, enquanto que o Beecf teve um comportamento variável segundo a terapia de reidratação utilizada. Houve efeito da interação tratamento x dia de avaliação apenas para a concentração de BUN (P<0,05). O pH, a concentração de Na+ e Beecf foram maiores em animais mais velhos, enquanto K+, hematócrito e hemoglobina, foram menores (P<0,05). O consumo voluntário de água foi maior em animais reidratados com Glutellac®, o que junto com a simplicidade de uso, representam as principais vantagens deste método de reidratação.The objective of this study was to evaluate the effect of milk replacer with high inclusion of vegetable protein in regard to performance and health of dairy calves, and evaluate rehydration methods for the treatment of diarrhea. In the first study 33 Holstein calvesdistributed in the treatments: 1) High volume and low protein (HV/LP): 8L/d, 21.4% CP; 2) High volume and high protein (HV/HP): 8L/d, 23.7% CP and 3) low volume and high protein (LV/HP): 6L/d, 23.7% CP. The calves were housed in individual shelters, with free access to water and starter concentrate. There was no effect of the treatments for animal performance (P>0.05). The treatments HV/LP and HV/HP resulted in higher milk replacer intake (P<0.05), but did not affect concentrate intake, neither the total dry matter intake (P>0.05). The fecal score was higher (P>0.05) for animals in treatments HV/HP and LV/HP. The animals in the treatments HV/LP remained more days in diarrhea (P<0.05), compared to LV/HP animals, which had fewer days with life (P<0.05). Lactate concentration was higher (P<0.05) for animals in treatments HV/LP and HV/HP while the concentration of total protein was higher (P<0.05) in treatments HV/LP and LV/HP. The use of milk replacer with high contents of vegetal protein, negatively affects the performance of calves and could lead to animals´ death. In the second study, three oral rehydration protocols were compared in regard to their efficiency in replace electrolytes and water, and in the maintenance of calves performance. Forty-two crossbred calves were used Holstein-Jersey, distributed in the treatments: 1) Common electrolytes oral solution, 2) Glutellac® and 3) Common electrolytes oral solution + Aminogut®. Calves were feed with 4 L/d of milk replacer until the eighth week of life when they were abruptly weaned. The rehydration therapy were offered when the animals presented fecal score >= 3 in a scale of 1 to 5. There was no effect of rehydration therapies for the variables related to animal\'s performance neither for blood metabolites (P>0.05). Voluntary water intake was greater for the animals that were rehydrated with Glutellac®, however total intake was higher for animals rehydrated with a common electrolytes oral solution. HCO3 and Na+ concentration were higher for the animals in the treatment Glutellac® (P=0.088 and p=0.073, respectively) being the glucose concentration also affected by protocol of rehydration (P<0.05). The HCO3 was increased from the first to the second day, the K+ and glucose reduced from the first to the second day, while the Beecf was variable according to rehydration therapy used. There was a significant interaction treatment x day only for the concentration of BUN (P<0.05). pH, concentration of Na+ and Beecf, were higher for older animals, while K+, hematocrit and hemoglobin, were lower (P<0.05). The voluntary water intake was significantly greater in animals rehydrated with Glutellac®, which together with simplicity of use, form the main advantages of this rehydrating.
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Wadell, Karin. "Physical training in patients with chronic obstructive pulmonary disease - COPD." Doctoral thesis, Umeå : Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-363.
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Tamarozzi-Bert, Federica. "Pratiques thermales : parcours thérapeutiques et plénitude physique." Thesis, Aix-Marseille, 2012. http://www.theses.fr/2012AIXM5021.
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Partagé entre d'anciennes traditions et une pratique médicale moderne, le thermalisme contemporain s'est construit comme une culture particulière de la santé qui confronte, sans pour autant les opposer, ces deux champs de savoir. Un regard ethnographique, fondé sur plusieurs terrains effectués en France (Aix-les-Bains) et en Italie (Salsomaggiore), permet de préciser plusieurs particularités de la pratique thermale européenne. En premier, l'expérience du corps et de la maladie relève autant de l'expérience individuelle que de l'expérience sociale. Dans la pluralité et la diversité des recours médicaux disponibles, le thermalisme a aussi cette particularité de mettre en avant la volonté du curiste qui est devenu un acteur de la « mécanique » physique et psychique du traitement. Non seulement il interagit activement avec ses thérapeutes mais il contribue à la construction et à la diffusion de la mythologie et de l'imaginaire thermal. Un imaginaire qui est d'ailleurs véhiculé par la ville thermale. Cette-dernière n'est pas qu'un lieu de cure mais plutôt un théâtre ou se met en scène et se légitime une certaine vision de la santé. Enfin, un dernier élément participe à l'épanouissement de la pratique thermale, le soin lui-même qui se compose de l'efficacité de l'eau et de la qualité des prestations des soignants. Ces derniers ont développé, au fil de leurs pratiques un rapport particulier au corps fait de proximité et de distance. Ils jouent ainsi le rôle du « passeur » et mettent en contact le curiste et la sourceShared between ancient traditions and modern health practice, contemporary hydrotherapy has become a peculiar health culture encompassing, without mutually excluding, both of these knowledges. This ethnographic work based on field studies in France (Aix-les-Bains) and in Italy (Salsomaggiore) shed light on several aspects of the use of hydrotherapy in Europe. First, the perception of one's own body and of the disease rises from both personal and social experiences. Among all available health practices, hydrotherapy is peculiar in giving a central role to its user, at the same time subject and object of both the physical and psychological aspects of the treatment. Not only he actively interacts with his therapists, but he plays a pivotal role in building and spreading the mythology and the imagination of thermal baths, which are in turn conveyed by the spa town. This becomes not just the geographical place where the therapy is held, but also and most importantly a stage to represent and legitimate a certain view of health. A final important aspect contributing to the flourishing of hydrotherapy is the treatment itself, the effectiveness of the therapeutic water, the quality of the services provided by the therapists who developed a particular relationship with illness. At the crossroads of different types of medicines, ‘ medecines savantes', popular and alternative medicine, modern hydrotherapy revealed itself as a dynamic reality whose plurality allows the use of syncretism to explain the combining of different (often contradictory) beliefs and practices
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Lišková, Nela. "Termální lázně Yverdon, pět smyslů v architektuře." Master's thesis, Vysoké učení technické v Brně. Fakulta architektury, 2015. http://www.nusl.cz/ntk/nusl-216150.
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The spa area is located in western Switzerland in Yverdon-les-Bains, which extends along the southern shores of Lake Neuchâtel. The aim was to replace the current Spa complex which capacity and operationally not meet today's requirements and also to increase capacity accommodation in the form of hotel. New spa complex is placed as solitaire in the area between the spa parks which creates fluent transition between them. Spa function is divided into multiple objects that have their own character, but which in their complexity creates one house. These objects "float" on the surface of the water, unites them and divides its operations at the same time.
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Birzniece, Vita. "Neuroactive steroids and rat CNS." Doctoral thesis, Umeå : Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-296.
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Ngule, Chrispus M. Jr. "In Vitro Adsorption of Heavy Metals Using Metal-Organic Frameworks." Youngstown State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1597664070125999.
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Hartung, Franziska [Verfasser], Walter [Akademischer Betreuer] Stühmer, Lutz [Akademischer Betreuer] Walter, Dieter [Akademischer Betreuer] Klopfenstein, and Matthias [Akademischer Betreuer] Dobbelstein. "Engineering of a bifunctional anti-Kv10.1 antibody for cancer therapy / Franziska Hartung. Gutachter: Lutz Walter ; Dieter Klopfenstein ; Matthias Dobbelstein. Betreuer: Walter Stühmer." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2011. http://d-nb.info/1042733465/34.
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Costa, Manuel da Cunha. "Crioterapia-efeitos na homeostasia muscular após o exercício." Phd thesis, Instituições portuguesas -- UP-Universidade do Porto -- -Faculdade de Ciências do Desporto e de Educação Física, 2002. http://dited.bn.pt:80/29515.
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Walter, Iris [Verfasser], and Albrecht [Akademischer Betreuer] Reichle. "Antiangiogenetische Therapie bei metastasiertem hepatozellulärem Karzinom / Iris Walter. Betreuer: Albrecht Reichle." Regensburg : Universitätsbibliothek Regensburg, 2016. http://d-nb.info/1104480549/34.
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Kupcová, Tereza. "Termální lázně Yverdon, pět smyslů v architektuře." Master's thesis, Vysoké učení technické v Brně. Fakulta architektury, 2015. http://www.nusl.cz/ntk/nusl-216167.
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Spa is located on the outskirts of the Swiss city of Yverdon. Area is surrounded by disparate buildings especially residential character. There are historical buildings on the land and buildings of the spa and hotel. The current spa and the outbuilding of hotel don´t meet requirements, that´s why the buildings will be replaced by a new complex. Neighbourhood doesn´t have any relationship with the spa, that´s why the whole land is surrounded by a wall. Water surface with three “floating” pavilions is inserted into this closed spa park. There are the public spa, the therapeutic spa and the part of the hotel on the water surface. Each of them works largely independently; they are connected by the water surface. The complex is separated by a part of shallow water from the park. It´s solitaire in the park, but it has close connection with it. The spa complex is located near the forest on the south part of the land, because the whole system is quite open.
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Rachinger, Walter [Verfasser]. "Konzepte der personalisierten Therapie von Tumoren der Schädelbasis und des Hirnstamms / Walter Rachinger." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2017. http://d-nb.info/1163200980/34.
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Dorst, Stephanie [Verfasser], and Walter [Gutachter] Brehm. "Diagnostik und Therapie des progressiven Siebbeinhämatoms beim Pferd / Stephanie Dorst ; Gutachter: Walter Brehm." Leipzig : Universitätsbibliothek Leipzig, 2014. http://d-nb.info/1238601871/34.
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Sewell, David Alexander. "Earth, air, fire and water : an elemental analysis of the Minoan eruption of Santorini volcano in the Late Bronze Age." Thesis, University of Reading, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250610.
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Schmidt, Walter [Verfasser], and Alexander [Akademischer Betreuer] Baethmann. "Wirksamkeit der medikamentösen Therapie des vasogenen Hirnödems : eine experimentelle Untersuchung / Walter Schmidt. Betreuer: Alexander Baethmann." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2013. http://d-nb.info/1033504475/34.
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Schweitzer, Finja [Verfasser], Walter [Akademischer Betreuer] Doerfler, and Kay [Akademischer Betreuer] Hofmann. "Host-specific innate and adaptive immune responses in therapy-naive human immunodeficiency virus 1 infected patients / Finja Schweitzer. Gutachter: Walter Doerfler ; Kay Hofmann." Köln : Universitäts- und Stadtbibliothek Köln, 2013. http://d-nb.info/1046939602/34.
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Theis, Ariane Verfasser], Walter [Akademischer Betreuer] Grünzweig, and Christoph [Gutachter] [Ribbat. "Cultures of Relating : Contextual therapy and family novels in American literature of the 21st century / Ariane Theis. Betreuer: Walter Grünzweig. Gutachter: Christoph Ribbat." Dortmund : Universitätsbibliothek Dortmund, 2014. http://d-nb.info/1111812071/34.
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Theis, Ariane [Verfasser], Walter Akademischer Betreuer] Grünzweig, and Christoph [Gutachter] [Ribbat. "Cultures of Relating : Contextual therapy and family novels in American literature of the 21st century / Ariane Theis. Betreuer: Walter Grünzweig. Gutachter: Christoph Ribbat." Dortmund : Universitätsbibliothek Dortmund, 2014. http://d-nb.info/1111812071/34.
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Natho, Oliver [Verfasser], and Walter [Akademischer Betreuer] Gross-Fengels. "Radiologisch-interventionelle Therapie von Endoleaks nach endovaskulärer Versorgung infrarenaler Bauchaortenaneurysmata / Oliver Natho ; Betreuer: Walter Gross-Fengels." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2018. http://d-nb.info/1163728918/34.
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Wüthrich, Walter. "Akute Pankreatitis : Eine retrospektive Untersuchung zu Klinik, Therapie und Verlauf in einem gemischten Krankengut/ Walter Wüthrich." Bern, 1991. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.
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Loktev, Anastasia [Verfasser], and Walter [Akademischer Betreuer] Mier. "Identifizierung und Charakterisierung FAP-spezifischer Liganden für die zielgerichtete Diagnostik und Therapie maligner Tumoren / Anastasia Loktev ; Betreuer: Walter Mier." Heidelberg : Universitätsbibliothek Heidelberg, 2018. http://d-nb.info/1177253445/34.
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