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Journal articles on the topic 'There is a need to conduct further research including a multi-centre'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Laraswatie, Harisa, Tjahjono Kuntjoro, and Sutopo Patria Jati. "Kebutuhan Perawat Puskesmas Berbasis Analisis Beban Kerja." Jurnal Manajemen Kesehatan Indonesia 4, no. 2 (2016): 118–22. http://dx.doi.org/10.14710/jmki.4.2.2016.118-122.

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A nurse’s necessity at a health centre viewed from workload analysis is required to identify a nurse’s necessities adjusted with service standards and real condition at a health centre. This requirement is in accordance with the change of an outpatient health centre status to be an inpatient health centre in which infrastructure and human resource need to be improved. This was a qualitative study using case study approach started from data collection, FGD, NGT, work sampling, to indepth interview with stakeholders who had experiences in calculating an employee’s necessities based on ABK and nu

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Masset, Heleen, Masoud Zamani Esteki, Eftychia Dimitriadou, et al. "Multi-centre evaluation of a comprehensive preimplantation genetic test through haplotyping-by-sequencing." Human Reproduction 34, no. 8 (2019): 1608–19. http://dx.doi.org/10.1093/humrep/dez106.

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Abstract STUDY QUESTION Can reduced representation genome sequencing offer an alternative to single nucleotide polymorphism (SNP) arrays as a generic and genome-wide approach for comprehensive preimplantation genetic testing for monogenic disorders (PGT-M), aneuploidy (PGT-A) and structural rearrangements (PGT-SR) in human embryo biopsy samples? SUMMARY ANSWER Reduced representation genome sequencing, with OnePGT, offers a generic, next-generation sequencing-based approach for automated haplotyping and copy-number assessment, both combined or independently, in human single blastomere and troph

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SHEN, Yanfei. "The Research Trend and Enlightenment of Value Education in the Foreign Language Courses of Colleges and Universities: A Research Based on Bibliometric Analysis." Asia-Pacific Journal of Humanities and Social Sciences 2, no. 1 (2022): 118–31. http://dx.doi.org/10.53789/j.1653-0465.2022.0201.013.p.

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With the method of bibliometric and qualitative analysis, this study reviews the literature on current value education in foreign language courses in colleges and universities from the perspectives of the general trends, journals, authors, fund projects, papers, and topics. It is found that with the deepening of value education nationwide, great attention has been paid to the research on “curriculum-based value education” and the number of research papers has shown a breakthrough growth in a short period. The research has obtained support from high-level and multi-type fund projects and focuse

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Tarce, Mihai, You Zhou, Alessandro Antonelli, and Kathrin Becker. "The Application of Artificial Intelligence for Tooth Segmentation in CBCT Images: A Systematic Review." Applied Sciences 14, no. 14 (2024): 6298. http://dx.doi.org/10.3390/app14146298.

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Objective: To conduct a comprehensive and systematic review of the application of existing artificial intelligence for tooth segmentation in CBCT images. Materials and Methods: A literature search of the MEDLINE, Web of Science, and Scopus databases to find publications from inception through 21 August 2023, non-English publications excluded. The risk of bias and applicability of each article was assessed using QUADAS-2, and data on segmentation category, research model, sample size and groupings, and evaluation metrics were extracted from the articles. Results: A total of 34 articles were inc

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Pelzer, Puck T., Marit Holleman, Michelle E. H. Helinski, et al. "The TB vaccine clinical trial centre directory: An inventory of clinical trial centres in Sub-Saharan Africa." PLOS ONE 19, no. 10 (2024): e0292981. http://dx.doi.org/10.1371/journal.pone.0292981.

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Background There are over ten vaccine candidates for tuberculosis (TB) in the clinical pipeline that require testing in TB-prevalent populations. To accelerate the clinical development of TB vaccines, a directory of clinical trial centres was established in sub-Saharan Africa (SSA) to assess capacity for conducting late-stage TB vaccine trials. Methods TB vaccine-related parameters were identified, and trial centres in SSA were identified and prioritized based on whether they had experience with TB or non-TB vaccine trials. A survey was sent to identified centres, and the resulting directory p

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Grobler, Mohini Meghan. "AN INVESTIGATION INTO THE VIABILITY OF BLOCKCHAIN INTEGRATION TO FACILITATE AN AFRICAN CURRENCY UNION." Journal of Law and Sustainable Development 13, no. 3 (2025): e04346. https://doi.org/10.55908/sdgs.v13i3.4346.

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Objectives: The objective of this study is to conduct a thought-experiment on a pan-African cryptocurrency union. It assesses the feasibility and potential impact by analysing related economic data and cryptocurrency usage statistics. It proposes a novel model for economic valuation for the hypothetical cryptocurrency, leveraging Metcalfe's Law and Zipf's Law. The methodology adopted for this study primarily comprises correlation and regression analyses over a 10-year timespan. Key findings suggest significant economic benefits, including enhanced financial inclusion and reduced trade barriers

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Wu, Robert M. X., Zhongwu Zhang, Wanjun Yan, et al. "A comparative analysis of the principal component analysis and entropy weight methods to establish the indexing measurement." PLOS ONE 17, no. 1 (2022): e0262261. http://dx.doi.org/10.1371/journal.pone.0262261.

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Background As the world’s largest coal producer, China was accounted for about 46% of global coal production. Among present coal mining risks, methane gas (called gas in this paper) explosion or ignition in an underground mine remains ever-present. Although many techniques have been used, gas accidents associated with the complex elements of underground gassy mines need more robust monitoring or warning systems to identify risks. This paper aimed to determine which single method between the PCA and Entropy methods better establishes a responsive weighted indexing measurement to improve coal mi

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Deng, Yanyao. "A Systematic Review of Application of Machine Learning in Curriculum Design Among Higher Education." Journal of Emerging Computer Technologies 4, no. 1 (2024): 15–24. http://dx.doi.org/10.57020/ject.1475566.

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Machine learning has become an increasingly popular area of research in the field of education, with potential applications in various aspects of higher education curriculum design. This study aims to review the current applications of AI in the curriculum design of higher education. We conducted an initial search for articles on the application of machine learning in curriculum design in higher education. This involved searching three core educational databases, including the Educational Research Resources Information Centre (ERIC), the British Education Index (BEI), and Education Research Co

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Boodai, Jawhara, Aminah Alqahtani, and Mounir Frikha. "Review of Physical Layer Security in 5G Wireless Networks." Applied Sciences 13, no. 12 (2023): 7277. http://dx.doi.org/10.3390/app13127277.

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Fifth generation (5G) wireless networks promise to revolutionize the way we communicate and connect to the internet. However, as with any new technology, 5G networks also bring new security challenges that need to be addressed. One of the key areas of concern is physical layer security, which refers to the protection of the physical layer of the network against attacks that could compromise its integrity and availability. In this systematic review, we examined the current state of research on physical layer security in 5G wireless networks. Our search identified 36 relevant studies that focuse

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Meena, Vasudev, Mohan Lal Dotaniya, Murli Dhar Meena, et al. "Sensor based precise nitrogen application augmented productivity and profitability of mustard (Brassica juncea L.)." PLOS ONE 19, no. 6 (2024): e0304206. http://dx.doi.org/10.1371/journal.pone.0304206.

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Unremitting decline in crop productivity and nutrient recovery are resulted due to dearth of need based fertilizer recommendation over blanket application apart from nitrogen pollution in several means. An advance nutrient management tactic, GreenSeeker (GS) has developed and used in many field crops following the principle of four “R” (right source, right amount at right time, and place) nutrients stewardship technologies. But no studies have been conducted for evaluation of GS in mustard for improving productivity, profitability and nutrient use efficiency (NUE) while minimizing environmenta

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Dr., Shazad Najeeb Dr. Arshad Sohail DR. Muhammad Ali Raza Dr. Chetan Das Priya Hotwani Dr. Suresh Kumar Rathi*. "FREQUENCY OF NECROTIZING ENTEROCOLITIS IN PRETERM NEONATES AND THEIR OUTCOME DURING HOSPITAL STAY." Indo American Journal of Pharmaceutical Sciences 04, no. 07 (2017): 2087–94. https://doi.org/10.5281/zenodo.835557.

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Background: Neonatal necrotizing enterocolitis [NEC], characterized by intestinal necrosis and pneumatosis intestinal, is the most common gastrointestinal emergency in the premature newborns[1] . The disease has an incidence rate of 2 to 5% in premature infants. The incidence rate increases to 13% in those weighing 1,500 gram at birth. NEC has a mortality rate of 10 to 55%. Objective: To determine the frequency of necrotizing enterocolitis in preterm neonates along with their outcome during stay in hospital. Methods: All premature newborn with morbidity admitted at Neonatal Intensive Care Unit

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Muhtaseb, Majed R. "Fraud against hedge funds: implications to operational risk and due diligence." Journal of Financial Crime 27, no. 1 (2020): 67–77. http://dx.doi.org/10.1108/jfc-03-2019-0032.

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Purpose The loss of an amount in excess of $100m cash deposit can be disruptive to the operations, definitely the liquidity of the hedge fund. Should a hedge fund liquidity position deteriorate, its compromised solvency could impact its vendors, most notably creditors and prime brokers. Large successful hedge funds do make basic mistakes. Lawyer Marc Dreier committed the criminal act of selling fraudulent promissory notes to hedge funds and others. Mr Drier’s success in selling fraudulent promissory notes was facilitated by his accomplices who posed as fake representatives of legitimate instit

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Logan, S., S. Hider, J. Green, and S. Ryan. "OP0275-HPR ‘IT’S A LOT TO TAKE IN’: A SYSTEMATIC REVIEW OF THE INFORMATION NEEDS OF PEOPLE WITH INFLAMMATORY ARTHRITIS STARTING METHOTREXATE." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 181.2–181. http://dx.doi.org/10.1136/annrheumdis-2023-eular.5533.

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BackgroundGuidelines recommend that people with Inflammatory Arthritis have access to tailored information when starting treatment with Methotrexate (MTX) [1]. It is not known what information people with Inflammatory Arthritis (IA) need to take MTX. Many people have concerns about the risk-benefit profile of MTX and so do not start or continue MTX.ObjectivesTo identify and synthesize knowledge of the characteristics, content and preferred format of information that people with IA need to take MTX.MethodsA PROSPERO registered systematic literature search (CRD42022325249) was conducted using Me

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Kut, Victoria, J. Mehta, S. Singhal, and C. Bennett. "Post-Marketing Assessments of Serious Adverse Drug Reactions Reported by the Manufacturer to the FDA Differ Markedly with Those from an Independent Pharmacovigilance Program: Empirical Findings Based on Bisphosphonate-Associated Osteonecrosis Descriptions by the Research on Adverse Events and Reports Project and the Product Manufacturer." Blood 104, no. 11 (2004): 3151. http://dx.doi.org/10.1182/blood.v104.11.3151.3151.

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Abstract Background: The Research on Adverse Events and Reports (RADAR) project, an independent pharmacovigilance project, has reported that post-marketing dissemination of clinical information on systemic adverse drug reactions (sADRs) in the FDA approved package labels of cancer drugs is often incomplete, delayed, or absent. Methods: We compared post-marketing clinical assessments describing one previously unreported sADR: zoledronate (Z) and pamidronate (P)-associated osteonecrosis (ON) of the jaw. Data sources included 1) information submitted to the FDA by the manufacturer in support of a

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Smirnova, E. E. "Assessment and Prediction of the Environmental Performance of Multi-Component Cements Using Statistical Analysis." Safety of Technogenic and Natural Systems, no. 2 (June 9, 2025): 87–101. https://doi.org/10.23947/2541-9129-2025-9-2-87-101.

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Introduction. The cement industry, a cornerstone of the construction sector, generates significant CO2 emissions (5–8% of global totals). Amid growing demands for sustainable development and green construction, the development of multi-component cements (MCCs) with clinker partially replaced by active mineral additives (slag, phosphogypsum) is critical for reducing environmental impact while enhancing properties such as sulfate resistance, strength, and deformation control. The core problem lies in the lack of systematic statistical approaches to optimize MCC compositions, which hinders achiev

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Miao, Iris Yi, and Yuen Shan Christine Lee. "29 Cultural Considerations for Neuropsychological Assessment and Cognitive Rehabilitation Planning in Patients Immigrating from China." Journal of the International Neuropsychological Society 29, s1 (2023): 904–5. http://dx.doi.org/10.1017/s1355617723011116.

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Objective:Research on healthcare disparities has found that racial and ethnic minority population were less likely to receive intensive and effective rehabilitation following an acquired brain injury compared to their White counterparts. Immigrant status and language barriers further perpetuate the disparities in access to rehabilitation care. In addition to institutional barriers such as absence of culturally and linguistically appropriate health materials as well as lack of cultural competency training for staff, patient factors such as dissonance in cultural value orientation to health care

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Yuan, Xiaohan, Jinfeng Li, Dongxia Wang, et al. "S-Eval: Towards Automated and Comprehensive Safety Evaluation for Large Language Models." Proceedings of the ACM on Software Engineering 2, ISSTA (2025): 2136–57. https://doi.org/10.1145/3728971.

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Generative large language models (LLMs) have revolutionized natural language processing with their transformative and emergent capabilities. However, recent evidence indicates that LLMs can produce harmful content that violates social norms, raising significant concerns regarding the safety and ethical ramifications of deploying these advanced models. Thus, it is both critical and imperative to perform a rigorous and comprehensive safety evaluation of LLMs before deployment. Despite this need, owing to the extensiveness of LLM generation space, it still lacks a unified and standardized risk ta

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Garway-Heath, David F., Haogang Zhu, Qian Cheng, et al. "Combining optical coherence tomography with visual field data to rapidly detect disease progression in glaucoma: a diagnostic accuracy study." Health Technology Assessment 22, no. 4 (2018): 1–106. http://dx.doi.org/10.3310/hta22040.

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Background Progressive optic nerve damage in glaucoma results in vision loss, quantifiable with visual field (VF) testing. VF measurements are, however, highly variable, making identification of worsening vision (‘progression’) challenging. Glaucomatous optic nerve damage can also be measured with imaging techniques such as optical coherence tomography (OCT). Objective To compare statistical methods that combine VF and OCT data with VF-only methods to establish whether or not these allow (1) more rapid identification of glaucoma progression and (2) shorter or smaller clinical trials. Design Me

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De Silva, Nisha, Sandra Robrecht, Can Zhang, et al. "Analysis of Outcomes of Younger (≤ 55 Years) Compared with Older (> 55 Years) Patients with Chronic Lymphocytic Leukaemia (CLL) in Seven Studies Conducted By the German CLL Study Group (GCLLSG)." Blood 134, Supplement_1 (2019): 4293. http://dx.doi.org/10.1182/blood-2019-126528.

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Introduction Although the median (med) age at diagnosis of CLL is 72 years (yrs), 11% are less than 55 yrs of age (SEER database). For this significant proportion of younger patients (pts), there exists a paucity of published data, particularly with regards to long-term follow up and safety. In recent years, single-centre retrospective analyses of younger CLL pts have been published (Parikh et al. 2015, Getta et al. 2018.) but this is the first study using data from international prospective randomised multi-centre trials, representing a large and diverse cohort of pts. Methods We performed a

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Baxter, Susan, Lindsay Blank, Maxine Johnson, et al. "Interventions to promote or maintain physical activity during and after the transition to retirement: an evidence synthesis." Public Health Research 4, no. 4 (2016): 1–354. http://dx.doi.org/10.3310/phr04040.

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BackgroundIt has been argued that transition points in life, such as the approach towards and early years of retirement, present key opportunities for interventions to improve the health of the population. Interventions that may change or preserve activity levels around the time of retirement have the potential to provide benefits in terms of increased health and well-being for people in later life. Research has highlighted health inequalities in health statuses in the retired population and in response to interventions.ObjectiveWe aimed to conduct a systematic review and meta-synthesis of the

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Evans, Rachel, Hayley Williams, Lisa Love-Gould, et al. "A service improvement project exploring the extent of need for allied health care professionals within neuro-oncology in Velindre Cancer Centre." Neuro-Oncology 21, Supplement_4 (2019): iv9. http://dx.doi.org/10.1093/neuonc/noz167.037.

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Abstract Given the highly complex and holistic needs of neuro-oncology patients, gold standard guidelines recommend that support is best served by a coordinated multi-disciplinary team (MDT) to provide seamless care from diagnosis to end of life (NICE 2018). Allied Healthcare Professionals (AHPs) including occupational therapy (OT), physiotherapy (PT), speech and language therapy (SLT) and dietitians (DT) are recognised as key professions within the MDT. As there is no designated AHP team at Velindre Cancer Centre, input can be reactive and fragmented with limited opportunity for patient educa

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Todoriko, L., I. Margineanu, I. Semianiv, et al. "Factors influencing drug susceptible tuberculosis outcomes in Eastern Europe." Tuberculosis, Lung Diseases, HIV Infection, no. 4 (December 5, 2022): 13–21. http://dx.doi.org/10.30978/tb-2022-4-13.

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Objective — to conduct a retrospective analysis of factors that affect the results of treatment of patients with tuberculosis. Materials and methods. A retrospective multi-center study was conducted on adult (> 18 years) patients diagnosed with drug-sensitive susceptible TB of any form and initiated treatment between 1st of January 2019 — 31st of December 2019. The Bucharest Marius Nasta Institute, the Iasi Lung Hospital in Romania, and Chernivtsi TB Centre in Ukraine participated in this study. The study was approved by the ethics committee of each centre (Iassi: 5483/2021, Bucharest

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Simamora, Windi Saputri, Siti Sarah Harahap, Akbar Idaman, and Septian Simatupang. "Analysis of the Multi Objective Optimization by Ratio Analysis (MOORA) Method in Determining Pilot Areas at PT. XYZ." Journal of Computer Networks, Architecture and High Performance Computing 6, no. 3 (2024): 1098–106. http://dx.doi.org/10.47709/cnahpc.v6i3.4149.

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This research analyzes the application of the Multi Objective Optimization by Ratio Analysis (MOORA) method model in determining the Pilot Area at PT XYZ. This method is used to evaluate various performance criteria, including customer satisfaction, productivity, service quality, and operational efficiency. Currently, the Pilot Area assessment and selection process at PT XYZ is still done manually, which causes a lack of accuracy and efficiency. MOORA was chosen for its ability to handle multi-criteria decision-making problems more systematically and objectively. The analysis results showed th

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Janné, Mats, and Anna Fredriksson. "Construction logistics governing guidelines in urban development projects." Construction Innovation 19, no. 1 (2019): 89–109. http://dx.doi.org/10.1108/ci-03-2018-0024.

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Purpose Although a construction logistics solution is necessary for dealing with the demands in many large urban development projects, there is a lack of research on governance mechanisms for construction logistics solutions. Therefore, the purpose of this paper is to analyse the initiation and utilisation of a construction logistics centre (CLC) from different stakeholders’ perspectives to suggest governance mechanisms for strategic, tactical and operational levels and to develop guidelines for implementing these governance mechanisms. Design/methodology/approach A single case research design

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Shen, Yongting, and Hongxing Yang. "Multi-Objective Optimization of Integrated Solar-Driven CO2 Capture System for an Industrial Building." Sustainability 15, no. 1 (2022): 526. http://dx.doi.org/10.3390/su15010526.

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Industrial CO2 emission, accounting for nearly a quarter of the total CO2 emission, is a “hard-to-abate” emission sector, owing to the longstanding challenge in reducing CO2 emission while not sacrificing industry economics. Herein, this research proposes an integrated solar-driven CO2 capture system for application in industrial buildings to decarbonize factories’ CO2-rich exhaust gas generated from workers or manufacturing processes, and further conducts multi-objective optimization based on the NSGA-II algorithm. By setting the integrated system’s performances, including captured CO2 mass,

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Karishma Singh and Deepashree Choudhury. "Designing inclusive cities: A framework for gender and age-responsive urban mobility." International Journal of Science and Research Archive 15, no. 1 (2025): 637–48. https://doi.org/10.30574/ijsra.2025.15.1.1031.

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Mobility plays a crucial role in ensuring social inclusion, economic participation, and overall quality of life. However, urban mobility systems often fail to address the needs of vulnerable populations, particularly women and the elderly. This study conducts a systematic literature review to identify urban design interventions that promote gender- and age-inclusive mobility. Initially, 80 peer-reviewed papers were selected from Scopus, Web of Science, and ScienceDirect, the most relevant databases for urban studies and mobility research. Through keyword frequency analysis, the selection was r

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Neimane, Leila. "Land-sea interactions: case studies from the Baltic Sea Region." SHS Web of Conferences 129 (2021): 08013. http://dx.doi.org/10.1051/shsconf/202112908013.

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Research background: Nowadays, mainstream discussions on maritime spatial planning (MSP) are tightly intertwined with the discourse on governance for land-sea interactions or interface (LSI), using multi-scalar and cross-sectoral governance systems. At the same time, principles with legal rank need to be respected and applied in both MSP and LSI and their respective governance structures while putting coastal communities at the centre and taking into consideration the process of “maritimisation.” In combination, these factors contribute to augmenting the pressure of competing uses both on land

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Md Fahim Ahmed, Kazi. "Vaccination Management Process and Challenges: Case of Bangladesh." Health Economics and Management Review 2, no. 3 (2021): 65–78. http://dx.doi.org/10.21272/hem.2021.3-06.

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The world is fighting an unexpected event of a pandemic. All over the world, people are living in fear of health of their own or family or the society World Health Origination says vaccination is the only solution to get rid of this COVID-19 pandemic. Vaccination needs effective and efficient management. Bangladesh, a developing South Asia with around 170 million population, is at high risk. On 8 March 2020, the first case of COVID-19 officially declared 1,580,559 confirmed cases and 28,041 deaths till now. This study aims to investigate and review the management and associated challenges of C

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McNamara, Mairead Geraldine, Jayne Swain, Zoe Craig, et al. "NET-02 final results: A randomised, phase II trial of liposomal irinotecan (nal-IRI)/5-fluorouracil (5-FU)/folinic acid or docetaxel as second-line (2L) therapy in patients (pts) with progressive poorly differentiated extrapulmonary neuroendocrine carcinoma (PD-EP-NEC)." Journal of Clinical Oncology 41, no. 4_suppl (2023): 646. http://dx.doi.org/10.1200/jco.2023.41.4_suppl.646.

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646 Background: As demonstrated in the primary analysis of NET-02, nal-IRI/5-FU/folinic acid, but not docetaxel, met the primary endpoint of 6 month (mo) progression-free survival (PFS) rate in pts with progressive PD-EP-NEC. Here, the final results are presented. Methods: This was a multi-centre, randomised (1:1), phase II trial of IV nal-IRI (70mg/m2 free base)/5-FU (2400 mg/m2)/folinic acid, Q14 days (ARM A), or IV docetaxel (75mg/m2), Q21 days (ARM B), as 2L therapy in pts with progressive PD-EP-NEC, aimed at selecting a treatment for continuation to a phase III trial. On disease progressi

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Anwar, Mahmood. "The Impact of Social Media on Adolescent Identity Formation and Mental Health: Opportunities, Risks, and Policy Implications." Sinergi International Journal of Psychology 2, no. 2 (2024): 66–79. https://doi.org/10.61194/psychology.v2i2.496.

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Psychological resilience is a critical factor in mental health and well-being, particularly in the face of increasing global stressors such as the COVID-19 pandemic. This study conducts a comprehensive narrative review to examine the key determinants of resilience, focusing on social support, stress management, cultural influences, and spirituality. A systematic literature search was conducted using Scopus, PubMed, and Google Scholar to identify empirical studies on resilience and its contributing factors. The findings underscore the significant role of social networks in enhancing resilience,

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Shen, Xinting. "Statistical Prediction and Marketing Recommendation of Foreign International Students’ Consumer Behavior." BCP Business & Management 36 (January 13, 2023): 7–15. http://dx.doi.org/10.54691/bcpbm.v36i.3379.

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Under a dynamic and complex educational market, it forces shape the educational environment. In the context of China, accelerating economic growth produces multiple newly Chinese multinational education institutions, which lack accurate analysis of consumer preference’s inherent characteristics with educational needs. Therefore, this research is vital in helping new Chinese multinational education institutions make decisions based on foreign countries’ students’ consumer preference and further filling the Chinese multinational education institution preference analysis’ gap. In statistics, this

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Kusumawati, Erna Dyah, Sasmini, and Adriana Grahani Firdausy. "Achieving Fair and Equal Access to Vaccination for Persons with Disabilities in Indonesia." Journal of Southeast Asian Human Rights 8, no. 2 (2024): 314–46. https://doi.org/10.19184/jseahr.v8i2.4455.

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The World Health Organisation has recommended that its member states conduct national vaccination programs based on fair and equal access principles. COVID-19 has had more severe impacts on persons with disabilities (PwDs). This article focuses on how the provisions of international human rights instruments obligate countries to provide vaccination for PwDs. Further, these provisions will be used to analyse the law and policy adopted by the Indonesian government related to the vaccination program designed for this group. This article used both normative/doctrinal and empirical legal research m

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Kusumawati, Erna Dyah, Sasmini Sasmini, and Adriana Grahani Firdausy. "Achieving Fair and Equal Access to Vaccination for Persons with Disabilities in Indonesia." Journal of Southeast Asian Human Rights 8, no. 2 (2024): 314. https://doi.org/10.19184/jseahr.v8i2.35534.

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The World Health Organisation has recommended that its member states conduct national vaccination programs based on fair and equal access principles. COVID-19 has had more severe impacts on persons with disabilities (PwDs). This article focuses on how the provisions of international human rights instruments obligate countries to provide vaccination for PwDs. Further, these provisions will be used to analyse the law and policy adopted by the Indonesian government related to the vaccination program designed for this group. This article used both normative/doctrinal and empirical legal research m

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Layton, M., E. Johnson, S. Hall, et al. "The VCCC Research & Education Lead Program: Collective Leadership in Cancer Across Multiple Organisations." Journal of Global Oncology 4, Supplement 2 (2018): 156s. http://dx.doi.org/10.1200/jgo.18.60100.

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Background and context: The Victorian Comprehensive Cancer Centre (VCCC) is Australia´s first formally constituted comprehensive cancer center, based on NCI principles. It is an alliance of 10 organizations: 7 hospitals, 2 medical research institutes and a university, based in Melbourne, Australia. A key goal for the VCCC is to create meaningful collaborations across partner organizations. Aim: The VCCC established the Research & Education Lead (R & E Lead) Program to build leadership capability who can harness the critical mass of talent across the VCCC alliance to work toward optimal

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Kasembeli, Stanley Khaemba, and Mary Nyawira Mwenda. "Funding Diversification and Performance of Education Projects Implemented by Non-Profit Organizations in Dadaab Refugee Complex, Kenya." International Journal of Advanced Research 8, no. 1 (2025): 252–64. https://doi.org/10.37284/ijar.8.1.3177.

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The performance of education projects is integral in protracted situations where refugees hope to find durable solutions to displacement from their countries. The Dadaab refugee complex is one such area that hosts thousands of school-going populations who rely on the performance of education projects. Studies have shown that a significant number of projects fail due to a myriad of challenges, including poor management strategies, which delay the project implementation and completion within the constraints of time while minimizing cost overruns. However, there are limited studies that have link

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Hidalgo-Mazzei, Diego, Michael Berk, Andrea Cipriani, et al. "Treatment-resistant and multi-therapy-resistant criteria for bipolar depression: consensus definition." British Journal of Psychiatry 214, no. 1 (2018): 27–35. http://dx.doi.org/10.1192/bjp.2018.257.

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BackgroundMost people with bipolar disorder spend a significant percentage of their lifetime experiencing either subsyndromal depressive symptoms or major depressive episodes, which contribute greatly to the high levels of disability and mortality associated with the disorder. Despite the importance of bipolar depression, there are only a small number of recognised treatment options available. Consecutive treatment failures can quickly exhaust these options leading to treatment-resistant bipolar depression (TRBD). Remarkably few studies have evaluated TRBD and those available lack a comprehens

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Kiss, E., G. Poór, G. Zahuczky, et al. "AB0199 GENES PREDICTIVE ON THE EFFICACY OF INFLIXIMAB IN THE TREATMENT OF RHEUMATOID ARTHRITIS: A PROSPECTIVE, MULTI-CENTRE, CLINICAL PERFORMANCE EVALUATION STUDY FOR AN IN-VITRO DIAGNOSTICS MEDICAL DEVICE." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1400.2–1400. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5849.

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Background:Approximately 30% of rheumatoid arthritis (RA) patients fail to respond to first biological therapy, thus treatment selection of biologic therapy for patients with RA is of high importance. The lack of biomarkers to predict specific biological treatment response, in the case of non-responder (NR) patients leads to unnecessary exposure, delay of adequate therapy, progression of the disease and therapy cost increase. Predicting the patient’s responsiveness to the first biological therapy is still an unmet need in the clinical setting. Predictive in vitro testing would have a significa

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Wu, Haoyuan, Liangxu Wang, Zhonghao Zhang, and Jun Gao. "Analysis and optimization of 15-minute community life circle based on supply and demand matching: A case study of Shanghai." PLOS ONE 16, no. 8 (2021): e0256904. http://dx.doi.org/10.1371/journal.pone.0256904.

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The 15-minute community life circle (15min-CLC) strategy is one of Shanghai’s important methods for building a global city and facing a society with a more diverse population structure in the future. In the existing research, the balance between the construction of the life circle and the needs of the people in the life circle still needs to be further fulfilled. This paper is based on the city’s multi-source large data set including 2018 AutoNavi POI (Point of Interests), OSM (OpenStreetMap) road network data and LandScan population data set, and evaluates the current status of Shanghai’s 15m

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Vora, Ajay, Rachel Wade, Christopher Mitchell, Nicholas Goulden, and Sue Richards. "Incidence and Outcome of Osteonecrosis in Children and Young Adults with Acute Lymphoblastic Leukaemia Treated on a Dexamethasone Containing Protocol: Results of the Medical Research Council UK Trial ALL 2003." Blood 112, no. 11 (2008): 910. http://dx.doi.org/10.1182/blood.v112.11.910.910.

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Abstract There is concern that dexamethasone is associated with a higher risk of ostenecrosis than prednisolone when used in older children and young adults with Acute Lymphoblastic Leukaemia. UKALL 2003 is an ongoing randomised controlled trial in which patients receive dexamethasone 6 mg/m2 for 29 days during induction and 5 days each month during maintenance in combination with Vincristine. Additionally, they receive 10 mg/m2 for 14 days in an alternate week schedule during each of two delayed intensifications. The trial is investigating whether treatment can be adjusted according to Minima

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Gandhi, Shreyans, Jie Jiang, Simon Slade, et al. "Telomeric Length to Characterize and Prognosticate Bone Marrow Failure, Risk of Clonal Evolution and Multi-System Complications in Aplastic Anemia and Other Hypocellular Cytopenic Disorders, Independent of Telomere Gene Complex Mutations." Blood 134, Supplement_1 (2019): 3749. http://dx.doi.org/10.1182/blood-2019-130754.

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Introduction Telomere length is shortened in patients with idiopathic aplastic anemia (AA) and other bone marrow failure disorders (BMFD) and predicts risk of clonal evolution (CE), relapse and overall survival (OS). Telomereopathies predominantly cause bone marrow failure, are multi-systemic disorders with variable penetrance, and may involve inter-play of other factors in disease manifestation and organ affliction. Telomere length (TL) in AA and other hypocellular BMFD, independent of mutations in telomere genes (TGC), has not been studied as a scoring tool, as well predicting the risk of af

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Carter, Mathew, Katherine D. Brown, Helen Adderley, et al. "Abstract 2494: RAS-Bio a unique pan-cancer biobank for RAS-driven tumors." Cancer Research 84, no. 6_Supplement (2024): 2494. http://dx.doi.org/10.1158/1538-7445.am2024-2494.

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Abstract Background: RAS-driven cancers represent a significant unmet clinical need, while breakthroughs in treatments targeting KRASG12C driven-NSCLC have invigorated drug-development for other RAS mutant cancers. Most RAS mutant cancers are not driven by KRASG12C, leaving an enormous amount of work needed to establish the contextual treatment vulnerabilities of cancers driven by different RAS mutant subtypes. RAS-Bio was pioneered within The Cancer Research UK Lung Cancer Centre of Excellence in Manchester. RAS-Bio is a uniquely curated resource of unparalleled clinical, genomic, translation

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Cook, Gordon, Charlotte Pawlyn, Kara-Louise Royle, et al. "Dynamic Frailty Assessment in Transplant Non-Eligible Newly Diagnosed Myeloma Patients: Initial Data from UK Myeloma Research Alliance (UK-MRA) Myeloma XIV (FiTNEss): A Frailty-Adjusted Therapy Study." Blood 142, Supplement 1 (2023): 4748. http://dx.doi.org/10.1182/blood-2023-188672.

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Background Multiple myeloma (MM) is a blood cancer that predominates in the older adult with significant morbidity and mortality. Frailty is increasingly recognized as a predictor for long- and short-term outcomes, with those who are frailer at risk of greater toxicity, treatment discontinuation and poorer survival. Identifying and tailoring treatment for frail older patients with MM remains an unmet need. The International Myeloma Working Group frailty score (IMWG FS) is a prognostic biomarker for survival, but no evidence exists for its predictive biomarker potential. In addition, defining f

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Binda, Catherine, Sanya Grover, Amy Beevor-Potts, et al. "R1 (Resident Advocacy Project) Flexible and Enhanced Learning with our RICHER Partners: Reciprocal Partnerships between Medical Students and Equity-Deserving Communities to Promote Vaccine Access and Teach Health Advocacy." Paediatrics & Child Health 28, Supplement_1 (2023): e54-e54. http://dx.doi.org/10.1093/pch/pxad055.112.

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Abstract Rationale and Objectives The University of British Columbia provides medical students in years 1, 2, and 4 with protected time to explore the CanMEDs competencies in student-directed service, education, and research through the Flexible and Enhanced Learning (FLEX) program. Six FLEX students in the past three years have engaged in reciprocal partnerships with the Responsive, Intersectoral Community Child Health Education and Research group (RICHER). RICHER is a consortium of interdisciplinary healthcare providers, resource centres, and community members working across sectors and syst

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Macklin, James, Donald Baird, and Keith Newton. "Ecobiomics: Environmental metagenomic biomonitoring." Biodiversity Information Science and Standards 3 (July 30, 2019): e38439. https://doi.org/10.3897/biss.3.38439.

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Land use disturbances are having enormous adverse impacts on the biodiversity and integrity of natural and managed ecosystems around the world. Adverse impacts on biodiversity are compromising ecosystem services and processes, reducing ecosystem resilience, and leading to unpredictable ecosystem responses to environmental change. The Metagenomics-Based Ecosystem Biomonitoring Project (EcoBiomics) focuses on the urgent need to better understand the extent and significance of ongoing changes to biodiversity in the soil and aquatic ecosystems that sustain essential ecosystem services upon which C

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Louis, Sherif, Nathalie A. Johnson, Pierre Brousset, et al. "Three-Dimensional Telomere Analysis Using Teloview® Technology Predicts the Response of Classic Hodgkin's Lymphoma Patients to First Line Therapy at Point of Diagnosis." Blood 136, Supplement 1 (2020): 36–37. http://dx.doi.org/10.1182/blood-2020-140624.

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Classical Hodgkin's Lymphoma (cHL) has been well studied over the past few decades. Newly diagnosed patients are treated with combinations of chemotherapeutics, the most common of which includes adriamycin, bleomycin, vinblastine, dacarbazine (ABVD). Approximately 75-85% of newly diagnosed cHL patients show favourable outcomes in response to ABVD treatment resulting in long lasting remission. The remaining 15-25% of diagnosed cHL patients will either show primary resistance to ABVD or relapse during or after the completion of therapy. Despite the fact that cHL biology has been extensively inve

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Fjorden, Karin, Sara Ekberg, Nevzeta Kuric, et al. "Idelalisib in Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma: First Results from the Nordic Lymphoma Group NLG-LBC-07 (ILIAD) Phase II Trial." Blood 136, Supplement 1 (2020): 33. http://dx.doi.org/10.1182/blood-2020-133359.

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Introduction: Patients with relapsed/refractory diffuse large B-cell lymphoma (r/r DLBCL) who are ineligible for intensive chemotherapy and autologous stem cell transplantation have limited therapeutic options and poor prognosis, and there is an unmet need for new therapeutic alternatives in this situation. Based on gene expression profiling, DLBCL can be divided into the germinal centre B-cell (GCB) and the activated B-cell (ABC) subtype. These subtypes are dependent on different oncogenic pathways and may differ in responsiveness to targeted therapies. Idelalisib is a small-molecule inhibito

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Mehdizadeh, D., O. Johnson, D. Petty, M. Faisal, and P. Gardner. "Using risk prediction to case-find frail older people at risk of anticholinergic burden for Structured Medication Reviews: a qualitative study exploring the views and perspectives of primary care professionals." International Journal of Pharmacy Practice 30, Supplement_1 (2022): i4. http://dx.doi.org/10.1093/ijpp/riac021.005.

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Abstract Introduction Reviewing anticholinergic medicines is an important consideration in the safe care of frail older people. The cumulative effect of taking multiple anticholinergic medicines, known as anticholinergic burden (AB) (1), is associated with physical and cognitive decline, falls, and hospitalisation (2). There is a need to explore the development of integrated tools within clinical IT systems, to support safer prescribing. This includes the use of risk prediction, to case-find frail older patients at risk of AB for structured medication reviews (SMRs). However, using risk predic

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Chavda, Selina J., Marquita Camilleri, Andrew Hall, et al. "Evaluating Barriers to Enrolment into Multiple Myeloma (MM) Clinical Trials: Results from Health Care Professionals and Patient Survey from the UK Myeloma Research Alliance Equity, Diversity and Inclusivity (EDI) Working Group." Blood 144, Supplement 1 (2024): 3792.2. https://doi.org/10.1182/blood-2024-205315.

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Background: Under-representation in clinical trials from minority populations can lead to limited access to novel therapies as well as uncertain validity of trial data for these patients. We have previously demonstrated that patients from racial minorities and lower socio-economic classes were less likely to be represented in clinical trials for MM in the UK. Reported reasons are perceived stigma, cultural beliefs or distrust in clinicians. However, as each country has its own unique racial mix and Health and Social Care challenges, reasons for disparities may vary across countries. To evaluat

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Chopra, Pooja, Dr Prachi Verma, Dr Renu Lamba, and Dr Monica Bedi. "Modeling the Predictors of M-Payments Adoption for Indian Rural Transformation." Interdisciplinary Journal of Information, Knowledge, and Management 19 (2024): 028. http://dx.doi.org/10.28945/5381.

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Aim/Purpose: The last decade has witnessed a tremendous progression in mobile penetration across the world and, most importantly, in developing countries like India. This research aims to investigate and analyze the factors influencing the adoption of mobile payments (M-payments) in the Indian rural population. This, in turn, would bring about positive changes in the lives of people in these countries. Background: A conceptual framework was worked upon using UTAUT as a foundation, which included constructs, namely, facilitating conditions, social influences, performance expectancy, and effort

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Shyshkin, Viktor. "The place of small agricultural entrepreneurship in the development of amalgamated territorial communities." University Economic Bulletin, no. 48 (March 30, 2021): 7–20. http://dx.doi.org/10.31470/2306-546x-2021-48-7-20.

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Relevance of research topic. The number of Ukrainian holding-type organizations and their land bankcontinues to grow, "displacing" small and medium-sized producers from the agricultural economy.Since 2019, state policy has been refocusing on forced support for small and small-scale farms, and after the Ukrainian decentralization reform the leadership of the united territorial communities of the new tools they received depends on the development of small and medium-sized businesses. Formulation of the problem. Today, the actualization of local economic development requires significant financial

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